TWAS hub - CA8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0340	7.5e-03	0.060	0.015	0.050	0.036	0.051	8.6e-08	5.1e-03	9.5e-07	3.2e-05	7.6e-07
2	GTEx	Adipose Subcutaneous	0.1370	0.0430	1.7e-04	0.070	NA	0.089	NA	0.081	2.4e-06	NA	9.1e-08	NA	3.5e-07
3	GTEx	Colon Transverse	0.0930	0.0410	3.2e-03	0.003	NA	0.042	NA	0.035	2.1e-01	NA	4.3e-03	NA	8.4e-03
4	GTEx	Lung	0.1427	0.0392	8.6e-07	0.124	NA	0.128	NA	0.121	1.0e-09	NA	5.5e-10	NA	1.6e-09
5	GTEx	Muscle Skeletal	0.0562	0.0226	7.5e-04	0.010	NA	0.003	NA	0.006	3.1e-02	NA	1.5e-01	NA	8.2e-02
6	GTEx	Pituitary	0.3710	0.1010	5.4e-04	0.381	NA	0.312	NA	0.346	1.5e-10	NA	1.4e-08	NA	1.5e-09
7	GTEx	Small Intestine Terminal Ileum	0.2810	0.1110	3.6e-03	0.088	NA	0.082	NA	0.120	5.2e-03	NA	6.9e-03	NA	1.3e-03
8	METSIM	Adipose	0.1242	0.0331	7.8e-10	0.063	0.055	0.053	0.052	0.053	9.5e-10	1.0e-08	1.8e-08	2.6e-08	2.1e-08
9	ROSMAP	Brain Pre-frontal Cortex	0.0752	0.0327	5.2e-04	0.015	0.021	0.020	0.023	0.029	3.9e-03	7.9e-04	1.2e-03	5.0e-04	9.5e-05
10	YFS	Blood	0.0516	0.0151	4.3e-11	0.036	0.042	0.045	0.044	0.042	5.7e-12	9.7e-14	1.3e-14	3.2e-14	1.0e-13
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0464	0.0233	4.1e-04	0.037	0.025	0.025	NA	0.025	4.6e-05	6.7e-04	7.2e-04	NA	7.2e-04
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0550	0.0228	7.2e-05	0.019	0.044	0.024	NA	0.020	2.8e-03	8.9e-06	8.9e-04	NA	2.1e-03
13	TCGA	Thyroid Carcinoma	0.0520	0.0250	1.5e-04	0.038	0.031	0.024	NA	0.032	1.4e-04	5.0e-04	1.8e-03	NA	3.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Schizophrenia (2018)	4.8	9.9	17.4	-1.6	-1.9	-4.2	-3.9	-3.7	1.7	-3.7	-2.3	-2.9	-3.7	-3.8	-3.9	-2.0
Migraine (self-reported)	4.0	4.9	9.2	2.3	1.5	2.6	2.6	3.0	-1.5	1.6	2.3	1.8	2.3	2.8	2.4	1.0
Myopia	3.6	5.3	12.7	2.7	1.0	0.5	1.6	2.0	-3.4	0.5	3.6	3.1	1.9	1.3	2.5	2.7
Schizophrenia (2014)	3.3	7.4	14.1	-1.8	-1.4	-3.8	-3.4	-3.1	1.7	-2.7	-1.8	-3.2	-3.1	-3.0	-3.5	-1.5
Bipolar Disorder or Schizophrenia	2.8	6.9	11.7	-0.7	-1.4	-3.4	-3.2	-3.2	1.5	-2.6	-1.8	-2.4	-3.4	-3.1	-3.3	-2.2
Commuting to job workplace: Car/motor vehicle	2.8	3.2	7.2	-0.2	-2.2	-2.0	-2.5	-2.3	-0.2	-1.1	-0.8	0.6	-2.6	-2.7	-2.4	0.0
Blood White Count	2.7	20.3	66.1	-2.1	-3.1	-0.0	-2.0	-5.1	4.6	-0.0	-7.7	-5.0	-8.1	-2.0	-3.8	-5.5
Average weekly beer plus cider intake	2.7	4.0	8.9	-1.0	-2.0	-1.3	-2.8	-2.8	0.9	-0.8	-1.6	-0.6	-2.9	-2.5	-3.0	-1.2
Medication: Levothyroxine sodium	2.6	4.4	15.6	-2.6	-2.2	0.5	-0.2	-1.8	2.7	0.6	-2.3	-2.9	-3.9	0.1	-1.0	-1.8
Supplements: Fish oil (including cod liver oil)	2.6	3.3	6.3	-0.9	-1.3	-2.0	-1.8	-2.0	2.2	-1.9	-1.0	-2.0	-2.5	-1.4	-1.9	-2.1
Alzheimer’s Disease (in father)	2.3	2.5	8.4	2.1	0.4	1.6	0.7	1.4	-1.8	-0.1	1.8	2.9	1.8	0.4	1.5	1.3
Age at last live birth	2.3	3.3	7.3	2.7	2.0	-0.6	0.9	0.8	-2.5	-1.0	2.4	2.5	1.9	1.4	1.9	1.4
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	15.8	-2.9	-1.2	0.7	-0.2	-2.2	3.2	0.9	-1.8	-2.7	-4.0	0.6	-0.6	-1.4
Bipolar Disorder (2011)	2.1	2.0	4.7	1.2	-1.4	-1.9	-1.7	-1.6	-1.0	-1.3	-0.9	-0.8	-1.3	-2.2	-1.5	-0.8
Medication: Lansoprazole	2.1	2.4	12.0	-3.5	0.9	1.6	0.4	1.8	2.7	0.7	1.2	-0.3	-0.3	1.6	0.4	0.5
Prospective memory result	2.0	2.5	6.1	-0.3	-1.7	-0.9	-1.8	-1.2	0.5	-1.3	-2.5	-1.2	-1.2	-2.0	-2.4	-1.8
Headache pain in last month	2.0	3.4	11.2	1.1	0.4	3.4	2.5	2.6	-0.3	2.8	0.2	0.6	1.8	2.2	1.5	-0.4
Exposure to tobacco smoke outside home	2.0	2.7	7.0	-0.9	-2.3	-1.8	-2.2	-1.8	-0.3	-2.0	-0.8	0.0	-1.2	-2.6	-2.0	-0.1
Medication: Aspirin	2.0	2.7	6.3	-2.1	-2.5	0.7	-1.7	-0.9	1.7	-0.6	-1.8	0.0	-1.8	-1.8	-2.1	-1.4
Medication: Aspirin	2.0	2.6	6.8	-2.6	-2.3	1.1	-1.6	-0.5	2.0	-0.3	-1.8	-0.2	-1.3	-1.6	-2.1	-1.1
High cholesterol (Self-reported)	2.0	3.5	9.6	-1.6	-1.7	-1.3	-1.4	-1.9	2.0	0.9	-3.1	-2.2	-2.1	-1.2	-2.1	-1.7
Medication: Simvastatin	1.9	2.9	8.0	-2.2	-1.7	0.7	0.1	1.2	2.8	1.1	-2.8	-2.5	0.9	-0.1	-1.0	-1.6
Hypothyroidism (self reported)	1.8	4.1	18.5	-2.7	-1.1	1.1	0.3	-2.1	2.7	1.9	-1.9	-1.9	-4.3	0.8	-0.5	-1.5
Neuroticism (2016)	1.7	2.4	7.2	-1.3	-1.3	-0.6	-0.1	-2.1	2.3	-0.4	-1.5	-1.8	-2.7	-0.3	-0.7	-2.0
Vitamin and mineral supplements	1.7	2.3	10.7	0.3	-0.1	2.6	0.6	1.6	-0.5	0.3	1.7	1.6	1.1	0.6	1.0	3.3
Average weekly red wine intake	1.7	2.5	6.1	0.2	1.8	1.9	1.3	2.4	-1.0	0.4	0.9	1.5	2.5	1.3	1.8	1.5
Mineral and other dietary supplements	1.7	2.3	7.7	0.4	-0.2	1.9	0.2	2.0	-2.0	0.7	0.7	2.3	2.0	-0.2	0.5	2.8
Alcohol drinker status: Previous	1.7	1.9	3.8	0.6	1.9	1.5	1.6	1.4	-1.4	1.0	0.5	2.0	1.7	1.1	1.4	0.8
Ovarian Cancer	1.6	2.1	5.7	1.2	1.4	1.0	2.3	1.2	-1.4	0.6	1.2	1.2	1.4	1.8	2.4	0.7
Blood Red Count	1.6	15.2	49.6	3.0	2.2	3.3	7.0	2.9	-3.0	5.2	1.4	1.8	1.4	5.6	6.1	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.9	0.2	1.5	2.1	2.0	0.8	-0.8	0.4	1.8	1.1	1.3	2.0	2.2	0.5
Supplements: Vitamin C	1.6	1.9	6.0	0.7	-0.8	-1.0	-0.2	-2.1	-0.8	0.6	-2.4	-0.3	-2.0	-0.7	-0.9	-2.3
Prostate Cancer	1.5	2.1	5.0	-0.6	0.7	1.4	1.9	2.0	-1.0	1.8	0.9	0.5	1.8	2.2	1.8	0.7
Supplements: Zinc	1.5	1.7	5.9	-1.4	-0.3	0.3	0.2	0.2	0.8	1.3	-2.4	-2.2	-0.1	0.5	-0.7	-2.4
Stomach or abdominal pain in last month	1.5	1.9	7.3	-0.1	0.7	2.7	1.7	1.9	0.0	0.8	0.1	0.4	2.1	1.7	1.2	0.7
Medication: Atenolol	1.5	1.8	5.3	0.1	0.6	2.0	1.9	1.7	0.3	2.3	-0.9	-0.4	1.0	1.8	0.9	-1.3
Alcohol usually taken with meals	1.5	2.4	6.2	-0.2	1.8	1.1	2.5	1.7	0.1	1.8	0.7	1.0	2.0	2.0	2.3	0.0
Falls in the last year	1.5	2.0	9.7	-1.2	1.2	1.9	0.6	2.0	-0.4	0.8	0.4	1.6	3.1	0.6	0.2	1.3
Pulse wave reflection index	1.5	1.8	6.4	-0.4	-2.1	-1.4	-0.0	-0.3	-0.4	0.5	-2.4	-1.1	0.9	-0.5	-1.5	-2.5
Age at first live birth	1.5	2.7	9.2	3.0	2.2	-0.6	1.5	0.7	-2.1	-0.0	1.8	1.8	0.9	1.2	2.1	0.5
Number of treatments/medications taken	1.4	2.5	8.4	-2.9	-1.3	0.5	0.2	0.0	2.9	1.5	-0.7	-1.7	-1.6	0.4	-0.8	-2.0
Serious illness, injury or assault to yourself	1.4	1.7	4.1	-1.8	0.8	1.9	1.6	1.8	0.7	0.1	0.5	0.2	1.5	2.0	1.3	-0.3
Fluid intelligence score	1.4	2.9	8.0	0.3	1.6	2.8	1.7	1.9	-0.8	1.6	1.5	1.2	1.8	1.8	2.0	1.8
Breastfed as a baby	1.4	1.7	6.2	0.4	1.7	-0.1	0.5	1.4	-1.1	-1.0	2.5	2.1	0.4	0.9	1.5	0.9
Medication: Blood pressure	1.4	2.5	10.2	-2.7	-1.1	0.2	-0.2	0.1	3.2	0.2	-1.8	-2.2	0.2	0.2	-1.2	-1.9
Medication: Paracetamol	1.4	2.2	5.3	-0.8	2.2	0.6	1.7	1.1	-0.0	1.2	2.3	1.2	-0.3	2.3	2.1	0.5
Heart disease (siblings)	1.4	1.7	3.5	-1.8	-1.4	-1.5	-1.3	-0.0	1.7	-0.8	-1.6	-1.3	-0.2	-1.2	-1.9	-0.6
Medication: Co-codamol	1.3	1.5	6.8	-0.9	-1.3	-1.2	-1.0	-0.9	0.7	0.5	-1.2	0.1	-1.3	-1.0	-1.6	-2.6
Multivitamins +/- minerals	1.3	1.6	7.3	-0.7	-0.2	-2.1	-0.4	-0.7	1.2	-0.8	-1.2	-2.0	-0.8	-0.4	-0.8	-2.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	0.9	1.9	1.7	1.7	0.6	-0.5	1.1	0.7	1.0	1.1	1.4	1.5	1.0
Pulse wave Arterial Stiffness index	1.3	1.5	4.6	1.4	-1.7	-0.5	1.1	1.0	-1.7	1.1	-1.0	1.2	0.7	0.3	0.4	-2.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	10.1	2.5	1.0	-0.7	0.0	-0.1	-3.2	-0.3	1.2	2.4	0.4	-0.3	0.6	1.1
Pulse wave peak to peak time	1.3	1.5	4.3	-1.4	1.7	0.3	-1.1	-1.0	1.7	-1.1	1.0	-1.3	-0.9	-0.4	-0.5	2.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.1	0.0	-0.6	-1.5	-1.5	-1.1	0.5	0.5	-1.5	-0.6	-1.6	-2.0	-1.9	-0.7
Medication: Lisinopril	1.3	1.7	4.7	-0.4	1.4	1.6	1.8	2.2	0.9	0.6	0.1	0.3	1.7	2.2	1.0	-0.7
Cholesterol lowering medication	1.3	1.9	7.1	-1.6	-2.2	0.6	-1.1	-0.3	1.1	0.1	-2.7	-0.6	-0.7	-1.2	-2.0	-1.1
Lupus	1.2	1.8	4.4	-0.9	-1.6	0.8	-2.1	-1.8	0.9	-1.5	0.1	0.9	-1.4	-1.9	-1.1	1.3
Ulcerative Colitis	1.2	1.7	5.1	1.0	0.7	0.5	-0.3	0.5	-2.1	-0.4	2.2	1.6	1.7	-0.0	0.5	2.3
Relative age of first facial hair	1.2	2.4	7.2	0.1	0.6	-1.9	-1.3	-1.9	1.4	-1.9	-0.5	-2.4	-2.7	-0.5	-1.2	-1.1
Ever had hysterectomy (womb removed)	1.2	1.4	9.8	-0.3	-3.1	0.6	-0.6	-0.7	-0.9	0.1	-1.4	0.5	-0.9	-1.1	-1.1	-1.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.9	-0.9	-1.3	-1.0	-1.2	0.3	0.6	-2.2	-0.3	0.9	0.1	-1.7	-1.1	-1.1
Impedance of leg (left)	1.2	6.0	17.4	-0.6	-2.0	-4.2	-2.6	-3.9	-0.5	-1.4	-1.8	0.1	-3.4	-2.8	-2.6	-1.7
Happiness	1.2	1.4	5.8	-0.2	-0.2	0.3	-1.3	-1.1	0.6	-2.4	1.7	1.0	-0.6	-0.8	-0.2	2.2
Mouth/teeth dental problems: Dentures	1.2	1.9	7.3	-1.2	-0.4	0.4	0.4	-1.2	1.7	1.2	-1.9	-1.5	-2.7	0.3	-0.5	-2.0
Medication: Cholesterol lowering	1.2	1.9	9.3	-2.1	-0.8	0.2	-0.3	-0.1	3.0	0.3	-1.2	-2.6	-0.8	-0.1	-0.8	-1.1
Loud music exposure frequency	1.2	1.3	5.9	-0.0	0.2	2.2	-0.4	1.0	-1.0	-0.1	1.0	2.4	0.8	-0.6	0.1	1.3
Neck or shoulder pain in last month	1.2	1.8	6.2	2.4	-2.0	0.4	0.2	-0.6	-2.5	0.9	-0.4	1.7	-1.4	-0.3	-0.3	-0.8
Pulse rate, automated reading	1.2	3.8	11.4	-0.8	1.2	3.4	1.3	3.4	0.2	0.3	2.0	1.9	2.5	2.1	2.0	0.7
Handedness (chirality/laterality): Left-handed	1.2	1.4	6.2	0.2	-2.5	-1.3	-1.5	-0.3	1.2	-1.0	-0.6	0.1	-0.1	-1.5	-1.6	-0.2
Friendships satisfaction	1.2	1.5	4.8	-0.3	2.2	2.1	0.8	1.0	0.7	-0.5	1.0	0.2	0.1	1.7	1.0	1.6
Guilty feelings	1.2	1.9	6.5	-1.1	-1.1	0.0	-1.9	-1.2	1.6	-2.5	-0.1	-0.1	-1.8	-1.4	-1.6	0.1
Medication: Blood pressure	1.2	2.3	5.7	-1.8	1.5	2.2	1.6	2.4	0.7	2.2	0.1	-0.4	1.3	1.8	0.8	0.5
Illnesses of mother	1.1	1.4	7.8	1.7	-0.1	-0.2	-0.1	-0.6	-2.8	-0.2	0.7	2.1	0.6	-0.5	0.7	0.9
Birth weight of first child	1.1	2.0	14.0	1.3	-0.5	-0.1	-0.2	1.5	-1.8	-1.1	0.2	1.3	3.7	-0.5	0.3	1.0
Blood clot in the leg (DVT)	1.1	1.4	4.2	-1.0	0.3	2.0	1.3	2.0	0.3	1.7	-0.0	0.6	1.0	1.7	0.4	0.1
Qualifications: College or University degree	1.1	3.6	9.5	0.7	2.1	1.9	2.3	3.0	-0.0	0.4	1.5	1.1	3.1	2.3	2.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.7	-0.4	-1.0	1.1	0.6	0.1	1.5	1.7	-2.4	-1.9	-0.1	-0.1	-0.5	-0.2
Illnesses of father: None of the above (group 1)	1.1	1.4	4.8	-0.4	2.2	0.0	1.5	0.6	-0.1	0.6	1.4	0.2	-0.6	2.2	1.7	-0.5
Smoking status: Current	1.1	1.7	3.9	-1.4	-1.2	-0.9	-2.0	-1.9	1.6	-1.2	-0.2	-0.6	-1.0	-1.6	-1.8	-0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.9	-0.6	1.3	1.5	1.4	1.1	1.3	1.7	0.0	-0.2	-0.1	1.6	0.7	-1.7
Supplements: Calcium	1.1	1.2	6.8	0.0	0.4	-0.4	0.5	-1.7	1.1	0.5	-0.8	-1.5	-2.6	0.3	0.3	-0.8
Ulcerative Colitis (UC)	1.0	1.8	8.6	0.3	-0.0	1.1	0.3	0.3	-1.9	0.2	1.9	1.9	1.3	0.4	0.8	2.9
Impedance of leg (right)	1.0	4.8	14.4	-0.2	-1.8	-3.8	-2.2	-3.4	-1.0	-1.6	-1.6	0.8	-2.9	-2.5	-2.1	-1.2
Fed-up feelings	1.0	1.8	8.5	-0.1	0.9	2.9	0.7	0.9	0.2	-0.1	2.1	1.6	-1.0	1.4	1.3	0.8
Supplements: Glucosamine	1.0	1.2	3.8	0.2	0.5	-1.6	0.3	-2.0	1.2	0.5	-0.1	-1.7	-1.6	0.4	0.2	-1.5
Had other major operations	1.0	1.2	3.4	-0.3	-0.3	-1.1	1.3	-0.4	0.8	1.6	-1.4	-1.6	-0.5	0.7	0.3	-1.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.0	-2.0	-1.3	0.2	-1.3	0.1	1.5	-1.1	-0.8	-0.5	-0.0	-1.2	-1.5	-0.6
Shortness of breath walking on level ground	1.0	1.2	2.2	-1.4	-0.6	-0.7	-0.9	-1.1	0.9	0.2	-1.3	-1.5	-1.4	-0.3	-1.5	-1.0
Heart disease (mother)	1.0	1.3	3.7	0.1	0.7	1.2	1.9	1.5	1.1	1.0	-0.1	-0.3	-0.7	1.9	1.3	-0.5
Hypertension (Self-reported)	1.0	2.8	9.4	-3.1	-0.1	1.5	0.5	0.9	2.8	1.8	-1.9	-2.6	-0.0	0.8	-0.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	5.7	-1.2	-0.2	0.1	0.1	0.2	2.4	0.1	-1.0	-2.0	-1.6	0.4	-0.6	-0.7
Average weekly champagne plus white wine intake	1.0	1.4	4.9	0.5	0.1	0.5	2.2	0.8	-1.1	2.0	0.2	1.4	0.8	1.4	1.5	-0.4
Miserableness	1.0	1.8	6.0	0.2	1.6	1.9	0.8	-0.1	-0.2	0.2	2.4	1.3	-1.6	1.4	1.3	1.6
Unable to work because of sickness or disability	1.0	1.3	3.2	-1.3	-1.4	0.4	0.0	-0.4	1.4	1.6	-1.3	-1.8	0.3	0.1	-0.9	-1.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.5	0.3	1.2	2.3	1.2	1.5	-1.4	0.3	1.7	1.8	1.5	1.4	1.9	1.1
Mean Putamen Volume	0.9	1.1	2.3	-0.3	-1.2	-1.3	-1.5	-1.2	0.1	-1.4	0.0	0.4	-1.3	-1.4	-1.1	-0.0
LDL Cholesterol	0.9	1.4	6.7	-2.6	0.8	0.8	0.8	0.5	1.9	0.5	0.2	-1.4	-1.1	1.2	0.4	0.4
Average weekly spirits intake	0.9	1.1	4.2	-1.2	-1.8	-0.3	-0.3	-0.5	0.6	-0.9	-2.0	-1.5	0.6	-0.3	-0.9	-0.7
Severe depression (siblings)	0.9	1.0	3.6	-1.2	0.2	-0.1	-1.5	-0.7	1.3	-1.9	0.7	0.7	-0.7	-0.8	-1.3	-0.3
Current tobacco smoking	0.9	1.4	4.2	-0.5	-1.2	-0.9	-1.8	-2.0	1.0	-0.9	-0.3	-0.3	-1.0	-1.5	-1.6	-0.6
Relative age voice broke	0.9	1.4	5.5	0.8	0.9	-1.9	-0.9	-0.4	0.6	-1.3	-0.7	-2.3	-1.8	-0.6	-0.7	-0.4
Taking other prescription medications	0.9	1.4	3.8	-2.0	1.0	1.1	1.1	0.5	1.5	1.2	1.3	-0.1	-1.0	1.8	1.1	0.1
High blood pressure	0.9	2.6	9.6	-3.1	0.3	1.6	0.7	1.0	2.6	2.0	-1.3	-2.2	0.1	0.9	-0.4	-1.3
Body mass index (BMI)	0.9	3.6	13.8	-0.2	0.9	3.7	1.9	3.0	1.1	1.7	1.7	0.1	2.0	2.4	1.8	0.3
Alcohol intake versus 10 years previously	0.9	1.3	4.5	-1.5	-0.1	1.5	0.4	0.5	2.1	1.9	-0.3	-1.6	0.3	0.9	0.2	-0.8
Pulse rate	0.9	1.5	3.5	0.9	1.1	1.6	0.9	1.8	0.0	-0.1	1.9	1.2	0.7	1.1	1.8	1.3
Tense / ‘highly strung’	0.9	1.6	7.6	0.7	-0.5	0.9	-1.4	0.1	-0.6	-1.6	1.2	2.8	-0.4	-1.5	-0.6	1.5
Medication: Paracetamol	0.9	1.5	3.5	0.2	1.8	0.3	1.5	0.3	-0.9	1.1	1.8	1.4	-0.6	1.9	1.8	-0.0
Comparative body size at age 10	0.9	2.4	8.2	-0.0	2.9	0.9	0.1	2.3	1.1	-0.8	2.3	-0.7	1.3	1.6	1.4	1.7
Family relationship satisfaction	0.9	1.2	5.4	-2.3	0.8	1.2	0.4	0.5	1.6	-1.3	0.8	-0.1	0.2	1.4	0.6	0.3
Commuting to job workplace: Walk	0.9	1.0	3.0	1.7	1.1	-0.3	0.2	-0.8	-1.5	-0.6	1.4	0.6	-0.2	0.5	1.3	0.7
Back pain experienced in last month	0.9	1.3	3.5	1.1	1.9	1.3	0.9	0.9	-0.3	1.3	1.4	1.0	0.9	1.0	0.8	1.2
Medication: Bendroflumethiazide	0.9	1.3	2.4	-1.4	1.4	1.6	1.1	1.4	1.5	1.4	0.4	-0.0	0.6	1.1	0.9	1.1
Illnesses of father: High blood pressure	0.9	1.1	5.7	-0.0	-2.0	0.6	-0.1	-0.5	-0.5	1.3	-2.4	-0.5	0.4	-0.9	-1.2	-0.2
Fractured/broken bones in last 5 years	0.9	1.1	2.5	-0.5	1.2	1.6	1.4	0.9	-0.2	1.3	0.9	0.3	1.3	1.2	1.4	0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.3	-0.9	0.4	1.8	1.1	1.8	0.2	1.5	0.1	0.6	0.8	1.6	0.3	0.3
Depression (Nagel 2018)	0.8	1.3	5.7	-2.1	-0.4	1.1	-1.1	0.1	2.4	-0.8	0.5	0.3	-1.3	-0.4	-0.7	0.7
Smoking Status	0.8	1.9	5.7	-1.1	-2.4	-1.1	-1.5	-1.1	1.3	-0.4	-1.6	-0.5	-0.3	-1.5	-1.8	-1.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	-0.7	-0.4	1.3	1.6	0.5	1.1	1.5	-0.6	0.3	-0.0	1.3	0.5	-1.5
Pack years adult smoking proportion	0.8	1.1	8.4	2.9	-0.0	0.3	-1.0	-0.3	-1.4	0.1	0.6	1.4	-0.5	-0.9	-0.4	-0.0
High blood pressure (mother)	0.8	1.2	3.4	1.4	1.9	-1.3	-0.4	-0.7	0.5	-1.7	0.5	-1.5	-1.1	0.1	-0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.1	-1.9	0.7	1.6	-1.1	0.3	2.0	-0.6	0.6	-0.0	-0.1	-0.1	-0.7	1.4
Mouth/teeth dental problems	0.8	1.2	3.2	-0.7	-0.7	-1.3	-1.8	-0.1	-0.4	-1.7	0.6	0.8	0.4	-1.6	-0.9	1.5
Heart attack	0.8	1.0	3.6	-1.5	0.6	0.7	0.2	1.5	1.7	-0.1	0.4	-0.6	1.9	0.5	0.0	0.6
Pain all over the body in last month	0.8	0.8	3.6	-1.3	-0.6	-0.5	-1.0	-0.8	-0.2	-1.2	-0.4	0.2	-0.6	-0.3	-1.1	-1.9
Arm fat percentage (right)	0.8	3.0	7.4	-0.5	0.9	2.7	2.1	2.4	0.9	2.0	2.0	0.7	1.3	2.5	2.0	-0.1
Father’s age at death	0.8	1.1	4.4	2.1	1.3	-0.9	-0.2	0.1	-1.4	-1.0	1.2	1.0	0.1	-0.2	0.6	1.0
Lung cancer (father)	0.8	1.0	3.4	-0.8	1.9	0.1	0.9	0.4	0.2	0.3	-0.5	-1.3	-0.1	1.5	0.6	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	6.8	-0.5	1.8	1.0	0.0	0.1	0.7	-0.9	2.6	1.0	-1.0	0.9	0.8	0.8
Medication: Amlodipine	0.8	1.2	4.1	-2.0	-0.7	0.2	-1.2	-0.4	1.9	-1.0	-0.5	-1.1	-0.2	-0.4	-1.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.2	0.2	0.4	-2.0	-0.6	-1.4	0.7	0.5	-0.8	-0.9	-1.3	-0.8	-1.1	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.8	-1.1	0.8	1.9	0.8	0.6	1.1	0.9	-0.8	-1.5	0.1	0.9	0.5	-0.7
Mean time to correctly identify matches	0.8	1.6	7.8	-0.3	-0.4	-2.8	-0.7	-1.7	0.6	-1.2	-0.0	-0.1	-2.0	-0.4	-0.5	-1.8
Arm fat percentage (left)	0.8	3.1	8.1	-0.5	0.7	2.8	2.3	2.3	0.9	2.3	1.7	0.6	1.1	2.6	2.0	-0.3
Long-standing illness, disability or infirmity	0.8	1.3	5.8	-1.8	-0.5	2.4	0.0	1.1	1.8	1.1	-0.1	0.9	0.2	0.0	-0.5	-0.4
Breast cancer (self-reported)	0.8	1.0	6.2	1.1	-0.1	-0.2	0.6	-0.4	0.3	0.8	-1.6	-0.6	-0.8	0.2	-0.5	-2.5
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.1	-1.1	-1.0	-0.6	-1.6	-0.3	-0.5	-1.5	-0.8	0.1	-0.9	-1.1	-1.3
Mother’s age at death	0.8	1.0	5.1	1.2	-0.3	-2.1	0.3	-0.3	-0.5	-0.7	-0.6	-0.7	-0.0	-0.1	-0.1	-2.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.8	1.0	0.0	-2.2	-0.1	-0.2	-0.7	-1.3	0.1	1.1	0.1	-0.2	-0.0	-1.6
Ever depressed for a whole week	0.8	0.9	3.0	0.7	0.2	0.6	-0.4	0.8	-0.7	-1.5	1.7	1.6	1.2	-0.3	-0.1	1.0
Irritable Bowel Disease (IBD)	0.7	1.7	6.4	-0.2	0.5	2.0	0.7	0.8	-1.3	0.7	1.6	1.8	1.3	0.8	0.7	2.5
Major Depression (MDD)	0.7	0.9	1.9	0.3	0.8	1.0	1.4	-0.7	0.0	1.2	0.4	0.4	-1.3	1.3	1.1	0.7
Fasting Glucose	0.7	0.9	4.1	0.5	-0.4	-2.0	-1.2	-0.8	0.1	-0.6	0.2	-0.5	-1.4	-0.9	-0.8	0.5
Rheumatoid Arthritis	0.7	0.9	2.5	-0.3	-0.7	0.3	-1.4	-0.5	0.6	-0.7	-1.1	0.7	-1.4	-1.6	-1.4	-0.6
Lung FEV1/FVC ratio	0.7	3.3	8.7	-0.8	0.9	2.7	0.8	1.2	0.2	2.7	2.9	1.5	1.5	1.3	1.6	2.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.8	-1.5	-0.2	0.9	-1.3	-0.1	2.0	-1.2	1.0	0.6	-0.4	-0.6	-0.6	0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.1	-1.7	-1.4	0.0	-0.2	-0.2	0.5	-0.6	-1.1	0.1	-0.1	0.3	-1.0	-2.0
Diabetes (father)	0.7	0.9	3.4	-1.1	-1.9	1.3	-0.1	1.1	0.7	0.3	-1.6	0.1	0.4	-0.3	-0.7	-0.7
Depression (self-reported)	0.7	0.9	3.3	0.8	-0.1	1.4	0.1	0.0	-1.0	0.9	1.4	1.8	0.7	0.1	0.5	1.0
Arm fat mass (right)	0.7	2.7	6.7	0.3	0.9	2.6	1.9	2.2	0.7	1.9	1.9	0.7	1.4	2.3	1.9	0.1
Peak expiratory flow (PEF)	0.7	1.5	9.2	3.0	0.2	-0.2	0.2	-1.3	-2.3	0.6	0.5	0.7	-0.4	-0.2	1.1	1.0
Glaucoma (self-reported)	0.7	0.8	2.6	0.6	-0.5	1.0	0.2	0.1	-1.0	0.8	1.6	1.6	0.3	0.4	0.8	1.2
Birth weight	0.7	1.4	6.5	0.6	1.7	0.5	0.5	2.3	-0.0	0.0	0.6	0.8	2.6	0.9	0.5	1.0
Medication: Omeprazole	0.7	0.8	3.1	-1.8	-0.9	-0.7	-0.4	-0.3	1.2	0.7	-0.6	-0.2	-0.5	-0.4	-0.8	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	4.1	1.1	0.0	1.1	0.7	-0.1	-2.0	1.5	-0.6	1.0	0.2	0.4	0.2	0.1
Number of full sisters	0.7	0.9	2.2	0.5	-1.1	0.5	-1.3	-0.7	-0.6	-1.2	0.1	1.1	-1.1	-1.5	-0.8	0.6
Illnesses of father: Heart disease	0.7	0.9	3.1	-0.8	-0.7	-0.2	-1.5	0.0	1.2	-0.5	-0.4	-0.7	0.6	-1.5	-1.8	0.8
Smoking status: Previous	0.7	1.0	5.7	1.1	-0.8	-1.0	0.8	0.3	-1.3	0.6	-1.1	0.9	0.1	0.5	0.4	-2.4
Financial situation satisfaction	0.7	0.9	3.5	-0.0	1.1	1.9	0.5	0.8	0.1	0.5	1.1	0.7	0.7	0.6	0.8	1.6
Alcohol drinker status: Never	0.7	0.8	2.6	0.8	1.6	-0.2	0.6	0.9	-1.0	0.7	0.9	0.8	0.8	1.1	0.7	-0.9
Irritability	0.7	1.2	5.1	0.6	0.1	2.2	0.2	1.1	-0.1	-0.4	1.2	2.2	-0.8	0.3	0.9	0.9
Diastolic blood pressure, automated reading	0.7	2.1	8.0	0.3	0.0	1.3	2.4	1.8	-0.3	2.8	-0.4	0.2	0.2	2.1	1.3	-1.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	6.9	2.6	-0.5	-1.7	-0.9	-1.0	-2.0	-2.0	0.5	1.4	-0.6	-1.0	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.7	1.0	3.6	-1.6	0.5	0.5	0.2	1.3	1.9	-0.2	0.3	-0.7	1.8	0.4	-0.1	0.3
Impedance of whole body	0.7	3.6	15.2	-0.4	-0.9	-3.9	-1.2	-3.1	-1.1	-0.0	-1.3	0.6	-3.0	-1.6	-1.6	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	6.7	-0.8	-0.5	2.6	0.3	-0.3	0.5	-0.2	0.8	1.3	-1.9	1.3	0.4	-0.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.5	0.9	1.3	2.1	1.6	1.2	-0.9	0.5	1.2	0.9	1.2	1.5	2.0	1.5
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	-1.4	0.2	0.6	-0.3	1.0	1.3	-0.0	1.1	-0.3	1.4	0.5	-0.2	0.2
Crohns Disease (2017)	0.6	1.4	6.7	-0.6	0.6	2.6	1.4	1.5	0.0	1.5	0.4	0.9	0.9	1.2	0.6	0.9
Breast Cancer	0.6	1.5	3.4	-1.5	-0.1	1.4	1.8	1.2	1.2	1.5	-0.9	-1.0	1.1	1.6	1.1	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	3.2	-0.8	0.6	1.8	1.0	1.3	1.2	0.7	-0.3	-0.2	-0.1	1.1	0.7	-0.0
Crohns Disease (2012)	0.6	1.0	3.9	-0.5	-0.2	2.0	0.9	1.5	0.2	1.4	-0.3	0.1	1.9	0.4	0.3	0.1
HDL Cholesterol	0.6	1.1	3.5	0.1	-0.7	-0.5	-1.2	-1.1	1.5	-1.2	0.1	-1.7	-1.9	-0.2	-0.6	-0.2
Blood Eosinophil Count	0.6	4.5	9.7	1.2	2.5	1.8	2.9	-0.8	-0.8	3.1	1.9	-0.8	-2.2	2.6	2.4	-2.7
Lung FVC	0.6	3.2	10.6	0.3	0.1	-0.4	-2.9	-2.6	-0.6	-3.3	0.8	-0.3	-2.7	-2.0	-1.2	1.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.1	-1.1	-1.4	0.0	-0.2	-1.3	1.1	-0.1	-0.2	0.1	-1.0	-0.5	-0.6	0.0
Medication: Metformin	0.6	0.8	3.2	-1.8	-0.6	0.9	-0.4	1.0	1.0	-0.5	1.3	0.1	0.8	0.3	0.6	1.2
Townsend deprivation index at recruitment	0.6	0.9	3.1	1.0	-0.5	0.2	1.5	-1.1	-1.1	1.8	0.4	0.7	0.2	0.6	1.3	-0.0
Waist circumference	0.6	2.2	7.1	0.1	0.0	2.4	1.6	2.7	0.4	1.3	1.0	1.4	2.0	1.6	1.3	-0.7
Forced vital capacity (FVC)	0.6	2.2	5.5	1.9	-0.5	-1.0	-1.8	-2.4	-1.7	-1.3	-0.2	0.6	-2.3	-1.6	-1.0	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	1.5	0.8	1.1	1.2	0.5	-1.1	-0.8	0.9	0.9	0.8	-1.1	0.8	0.7	1.0
Hip circumference	0.6	2.6	8.0	0.6	0.7	2.4	1.5	2.8	0.1	2.2	1.2	1.0	2.2	1.6	1.4	0.6
Length of working week for main job	0.6	0.7	2.0	-1.3	0.2	-0.0	-1.1	0.2	1.4	-1.0	0.7	-1.1	-0.0	-0.4	-0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.5	-0.8	-0.8	-1.0	0.5	0.1	0.3	0.5	-1.8	-1.1	0.7	0.3	-0.4	-2.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.3	1.8	0.5	-0.1	1.0	0.0	-0.5	1.1	-0.8	-0.7	-0.1	0.7	0.6	-1.6
Number of full brothers	0.6	0.8	4.7	-0.2	0.1	1.2	-0.8	-0.5	-0.8	-0.5	0.7	1.0	-0.2	-0.8	-0.0	2.2
Health satisfaction	0.6	0.8	3.5	-0.1	0.2	1.9	0.9	0.4	-0.1	1.6	0.1	0.9	-0.0	0.3	0.8	1.1
Emphysema/chronic bronchitis	0.6	0.7	3.2	-1.8	0.7	0.1	-0.7	0.5	1.6	-0.4	0.2	-1.2	-0.5	0.1	-0.3	0.3
Illnesses of siblings: Diabetes	0.6	0.7	2.4	0.9	-0.5	-0.9	-0.8	-0.8	-0.3	-1.5	0.5	1.0	-1.3	-0.9	-0.4	-0.0
Eye problems/disorders: Cataract	0.6	0.7	2.9	-0.0	0.4	0.1	0.0	0.5	-0.2	0.5	1.7	1.4	-0.0	0.1	0.5	1.6
Osteoarthritis (self-reported)	0.6	0.7	4.0	-1.0	0.9	0.1	-1.3	0.0	2.0	0.1	1.3	0.1	-0.1	-0.4	-0.5	-0.2
Medication: Gliclazide	0.6	0.7	2.4	-0.8	-1.6	0.5	-1.3	-0.1	0.6	-0.9	-0.4	-0.2	0.2	-1.2	-1.1	0.0
Number of self-reported non-cancer illnesses	0.6	1.0	4.1	-0.3	-0.1	0.9	0.9	-0.6	0.9	1.6	-0.6	0.0	-2.0	0.6	-0.0	-1.5
Wears glasses or contact lenses	0.6	0.7	4.2	-0.2	-0.7	0.8	1.2	0.4	-0.3	0.7	-0.9	0.5	0.4	0.7	0.2	-2.0
Number of operations (self-reported)	0.6	0.8	1.8	-1.2	0.2	0.5	1.3	1.1	0.5	1.1	-0.8	-0.5	1.3	1.3	0.1	-0.6
Commuting to job workplace: Cycle	0.6	0.8	1.7	1.1	1.3	0.2	0.8	0.3	-1.1	-0.6	0.9	1.0	1.1	0.1	1.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.1	-1.8	-0.4	-0.8	-0.8	0.1	1.2	0.6	-0.2	0.3	-0.3	-0.5	-1.0	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	0.4	0.2	-0.7	1.3	0.6	-0.6	1.1	0.1	0.8	1.0	1.4	0.6	-0.5
Pack years of smoking	0.6	0.9	6.7	2.6	0.0	0.4	-0.7	-0.0	-1.2	0.3	0.5	1.2	-0.6	-0.7	-0.2	-0.4
Cardiovascular Disease	0.5	1.7	4.0	-2.0	-0.5	1.5	-0.4	0.1	2.0	1.8	-1.7	-1.8	0.3	-0.2	-1.3	-0.6
Chronotype (morning person)	0.5	1.2	3.1	-1.2	1.8	0.7	0.9	1.2	0.0	0.8	-0.0	-1.7	1.4	1.0	0.4	1.0
Hand grip strength (left)	0.5	1.3	5.4	0.8	-0.4	-0.5	-1.6	-0.7	-0.4	-1.9	0.9	0.1	-0.1	-1.5	-0.5	2.3
Leg fat-free mass (left)	0.5	2.5	5.3	1.0	1.3	2.0	1.4	2.3	0.2	1.4	2.1	0.5	2.1	1.8	1.9	0.9
Maternal smoking around birth	0.5	0.7	2.8	0.8	-0.9	0.5	-0.9	-1.7	-0.6	0.4	0.3	0.9	-0.8	-0.8	-0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.2	0.3	-1.0	-0.5	-1.0	-0.1	-0.8	-1.5	-0.1	0.4	1.0	-1.0	-0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.6	-1.2	-0.8	0.9	0.7	1.3	1.0	-0.4	0.0	-0.2	0.8	0.2	0.3	0.1
Hearing difficulty/problems with background noise	0.5	0.8	3.2	0.9	-0.7	-0.1	-0.1	-1.0	-0.2	-1.6	-0.9	0.6	-1.8	-0.7	-0.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-0.3	-0.2	0.8	-0.8	0.0	-0.4	-1.3	0.8	1.4	-0.3	-0.5	-0.4	1.1
Qualifications: None of the above	0.5	1.1	7.2	-0.2	-0.5	-0.4	-0.8	-1.9	0.5	0.9	0.6	-0.1	-2.7	-0.4	-0.5	-0.8
Financial difficulties in last 2 years	0.5	0.7	3.8	0.1	-0.2	1.9	0.0	0.8	0.3	-0.7	1.4	0.3	0.3	0.6	0.7	1.2
Illnesses of siblings	0.5	0.7	1.6	0.9	1.1	0.2	1.0	0.7	-0.5	1.3	-0.0	-0.7	1.2	0.8	1.0	-0.7
Time employed in main current job	0.5	0.6	3.2	-1.8	-0.8	0.6	0.5	0.6	1.2	-0.0	-0.5	-0.4	0.6	0.3	-0.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.4	0.8	-0.4	0.5	0.1	0.8	-1.1	0.3	0.5	1.5	0.3	-0.2	0.2	1.0
Hair/balding pattern: Pattern 4	0.5	1.2	3.7	-1.9	-1.2	0.1	-1.1	-0.3	1.4	-0.6	-1.4	-1.3	-0.6	-0.9	-1.4	-0.3
Gout (self-reported)	0.5	0.7	4.8	1.4	0.7	-0.7	0.6	0.2	-0.7	-0.0	-0.5	-0.0	0.2	0.4	0.2	-2.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.0	-1.4	-0.8	0.4	-0.5	0.9	1.3	0.1	-0.1	0.7	-0.4	-0.5	-0.9	-0.0
Worry too long after embarrassment	0.5	0.8	3.6	0.4	1.3	-0.8	0.5	-0.6	0.8	-0.9	0.5	-0.5	-1.9	0.7	0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.2	-0.6	-0.3	0.0	-0.8	0.0	1.1	-0.6	0.1	-0.4	-0.1	-0.6	-0.8	1.8
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.3	1.0	-0.8	0.9	0.3	-0.2	0.4	-0.9	-1.3	0.6	0.9	0.4	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	2.9	1.5	1.7	-1.0	0.2	-0.0	-0.9	-0.1	0.8	-0.0	1.0	0.6	0.7	0.7
Leg fat mass (right)	0.5	1.9	5.7	-0.5	0.3	2.4	1.2	1.9	1.4	1.3	1.7	0.4	1.5	1.7	1.3	0.1
Had major operations	0.5	0.6	2.2	-1.5	0.2	-0.6	-0.4	0.8	1.1	-1.3	0.3	-0.8	0.5	-0.0	-0.3	0.6
Leg fat-free mass (right)	0.5	2.4	5.1	0.8	1.2	2.0	1.4	2.3	0.5	1.6	1.9	0.0	2.2	1.8	1.7	0.7
Loneliness, isolation	0.5	0.6	2.8	-1.2	-0.8	1.7	-0.8	-0.2	0.1	-1.4	0.2	0.9	-0.0	-0.1	-0.1	0.3
Diabetes diagnosed by doctor	0.5	0.8	3.3	-1.2	-0.9	1.8	0.1	1.5	0.9	0.2	0.5	0.7	1.0	0.4	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.0	-0.0	1.0	1.3	0.6	0.1	0.2	0.7	1.7	-0.5	-0.8	1.0	1.3	2.0
Arm fat mass (left)	0.5	2.1	5.6	-0.1	0.5	2.4	1.7	2.0	0.9	1.7	1.7	0.4	1.2	2.1	1.6	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.5	0.3	-0.9	0.5	-0.4	-1.2	0.9	1.0	1.1	-1.0	0.5	0.4	-0.8
Neuroticism (Nagel 2018)	0.4	1.0	5.2	-0.0	-0.4	0.9	0.2	-0.4	0.2	-1.2	0.5	1.7	-2.3	0.6	0.3	-1.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	-0.8	1.1	-0.3	-0.7	-0.4	0.0	-1.3	0.6	-0.4	-0.8	0.0	-0.1	0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	-0.6	-0.2	0.8	-0.7	0.6	0.3	-1.0	1.3	1.0	1.2	-0.0	-0.3	0.1
HbA1C	0.4	0.4	1.3	-0.3	0.0	0.3	0.6	-0.1	0.8	1.1	-1.0	-1.1	0.6	0.3	0.1	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.6	0.8	-0.5	-0.1	-0.5	-0.1	-1.6	0.3	-0.7	0.8	0.2	-1.2	-0.6	-0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.8	-0.6	-1.1	1.7	0.5	1.4	-0.0	0.7	0.4	1.2	1.1	0.3	0.6	0.2
Sensitivity / hurt feelings	0.4	0.7	3.4	0.4	-0.9	-0.8	0.6	-0.6	-0.4	-0.5	-0.8	0.9	-1.2	0.2	0.1	-1.8
Medication for hormone replacement therapy	0.4	0.5	2.1	0.1	0.1	-1.5	-0.2	-0.2	-0.6	-1.4	0.9	0.3	0.6	-0.3	0.6	-0.3
Diabetes (mother)	0.4	0.5	1.8	0.2	-0.7	1.2	0.3	0.9	0.3	0.6	-0.2	0.4	0.8	-0.2	0.2	1.3
Hand grip strength (right)	0.4	1.1	1.9	1.3	0.9	1.2	1.0	1.0	-1.4	0.9	1.0	0.4	1.0	1.0	1.1	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.1	-1.8	0.5	0.6	-0.3	0.4	1.6	-0.2	0.9	-0.1	-0.0	0.3	0.0	0.2
Qualifications: CSEs or equivalent	0.4	0.5	2.7	-0.8	-0.0	1.0	0.7	-0.7	-0.2	1.6	-0.4	0.3	-0.6	0.7	-0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	4.1	0.4	0.7	-0.3	0.2	-2.0	-0.7	0.4	-0.8	-0.0	-2.0	-0.2	-0.3	-0.4
Leg predicted mass (left)	0.4	2.3	5.1	1.0	1.2	1.9	1.4	2.2	0.3	1.3	2.0	0.4	2.1	1.7	1.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	-0.0	0.5	1.2	0.9	0.5	-0.7	1.2	1.5	0.7	0.7	0.8	1.3	1.1
Diabetes (self-reported)	0.4	0.5	1.7	-1.3	-1.0	1.0	-0.3	1.1	0.8	0.3	0.1	0.4	0.9	0.0	-0.0	-0.0
Neuroticism score	0.4	0.9	3.3	0.1	0.0	1.1	-0.6	-0.3	0.5	-1.6	1.4	1.8	-1.4	-0.2	-0.0	0.4
Number of live births	0.4	0.5	2.4	-1.0	0.7	-0.4	-0.6	-0.3	0.3	-1.5	-0.5	-0.8	-0.3	0.2	-0.7	-1.0
Asthma	0.4	0.8	3.3	-1.0	0.9	1.4	1.2	0.6	0.2	1.8	-0.2	0.6	0.2	1.0	0.6	-0.2
Impedance of arm (left)	0.4	1.7	9.5	-0.0	0.4	-3.1	0.4	-1.6	-1.4	1.0	-0.2	1.2	-2.0	-0.1	-0.0	-1.0
Body fat percentage	0.4	1.7	4.0	-0.9	0.1	1.6	1.5	1.3	1.5	2.0	1.1	0.1	0.3	1.9	1.1	-1.5
Leg fat percentage (right)	0.4	1.6	5.5	-0.9	-0.3	2.4	1.0	1.8	1.4	1.0	1.2	0.6	1.4	1.4	1.0	-0.2
Medication: Ibuprofen	0.4	0.5	2.0	0.9	-0.8	1.4	0.0	1.1	0.0	0.4	-0.5	0.1	0.5	-0.7	-0.3	0.7
Medication: Seretide 50 evohaler	0.4	0.5	2.9	0.3	-0.4	-0.2	0.8	-0.3	-1.7	0.5	-0.0	0.6	0.0	0.6	0.6	-1.0
Whole body fat mass	0.4	1.6	3.4	-0.3	0.2	1.6	1.4	1.5	1.2	1.8	1.3	0.2	0.8	1.8	1.2	-1.0
Chest pain or discomfort	0.4	0.6	2.1	-0.6	1.0	1.5	0.3	0.3	0.9	1.4	-0.0	-0.2	-0.1	0.8	-0.1	-0.2
Leg pain on walking	0.4	0.5	2.3	-1.1	-0.1	0.2	0.4	-0.2	0.7	1.0	-0.4	0.1	-1.3	0.2	-0.3	-1.5
Knee pain experienced in last month	0.4	0.6	1.7	1.3	1.3	1.2	0.2	0.6	0.9	1.3	0.1	-0.1	-0.6	0.0	-0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.4	1.9	-0.3	-0.3	1.1	-0.2	-1.1	2.1	-0.1	0.7	0.1	0.3	0.5	-0.0
Mood swings	0.4	0.7	4.0	-0.2	-0.3	2.0	0.7	-0.4	0.6	0.2	0.4	0.7	-1.5	0.8	0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	0.8	-0.1	0.1	-0.7	0.1	-0.8	-1.4	0.4	1.0	-0.2	-0.6	-0.4	-0.0
Leg predicted mass (right)	0.4	2.2	4.7	0.9	1.2	1.9	1.4	2.2	0.4	1.6	1.9	0.0	2.1	1.7	1.7	0.6
Commuting to job workplace: Public transport	0.4	0.5	2.6	-0.3	-0.5	0.7	1.1	0.4	-0.2	0.1	-0.1	-0.4	0.0	1.2	0.7	-1.6
Medication: Atorvastatin	0.4	0.4	2.1	0.5	0.1	0.4	-0.9	-0.4	-1.0	0.1	0.6	0.8	-1.5	-0.4	-0.3	0.1
Pain experienced in last month	0.4	0.7	2.1	-1.4	0.8	-1.5	-0.6	-0.5	0.4	-0.8	0.5	-1.1	0.3	-0.0	0.2	1.2
Leg fat mass (left)	0.4	1.7	4.8	-0.6	0.2	2.2	1.1	1.8	1.5	1.3	1.6	0.1	1.3	1.6	1.2	-0.2
Age at First Birth	0.3	0.4	1.6	0.7	-0.9	0.3	0.8	-0.0	-0.7	1.0	-1.3	0.3	0.5	0.0	-0.1	-0.3
Primary Biliary Cirrhosis	0.3	0.5	2.0	1.4	0.5	0.1	-0.3	-0.2	0.0	-0.7	0.9	0.6	-1.2	-0.5	0.5	-0.2
BMI	0.3	1.5	6.7	-0.0	-0.6	2.6	0.3	2.4	1.3	0.4	1.2	0.3	1.6	0.4	0.6	0.3
Height	0.3	4.9	41.3	2.4	-0.9	-6.4	-1.6	-1.9	-1.4	-0.4	0.6	0.8	-1.4	-1.8	-0.9	-0.9
Systolic Blood Pressure	0.3	1.7	5.8	-1.2	-0.6	2.4	0.8	1.2	1.0	2.3	-1.7	-1.1	1.1	0.6	-0.8	0.1
Neuroticism	0.3	0.8	4.5	-0.3	-0.1	0.4	-0.7	-0.8	0.5	-1.4	0.5	1.2	-2.1	-0.1	-0.4	-0.7
Hearing difficulty/problems: Yes	0.3	0.5	2.2	0.8	-0.3	-1.5	-0.1	-0.3	-0.5	-0.3	-0.9	0.1	-0.4	-0.9	-0.4	-1.2
Systolic blood pressure, automated reading	0.3	0.8	2.6	-0.2	-0.4	1.1	1.3	1.0	0.5	1.6	-0.8	-0.3	0.0	1.2	0.3	-1.1
Trunk fat percentage	0.3	1.4	5.0	-0.6	-0.0	0.9	1.4	0.9	1.3	2.2	0.7	0.0	-0.1	1.6	0.8	-2.0
Average weekly fortified wine intake	0.3	0.4	1.6	-0.2	0.3	1.2	0.4	0.9	-0.4	-0.0	-0.5	0.2	0.2	0.4	-0.3	1.2
Age when periods started (menarche)	0.3	0.8	3.1	-0.7	0.4	1.2	0.4	0.6	0.0	1.3	0.6	-0.5	1.8	0.6	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.6	-0.8	0.1	1.4	1.1	0.7	-0.5	1.6	0.2	0.1	0.9	1.1	0.8	0.4
Sitting height	0.3	2.5	9.1	1.6	-0.9	-3.0	-1.9	-2.8	-0.3	-0.7	0.1	-0.2	-1.7	-1.9	-1.2	-0.0
Trunk fat mass	0.3	1.3	4.4	-0.1	0.1	1.1	1.4	1.2	1.1	2.1	1.1	0.1	0.5	1.7	1.0	-1.4
Past tobacco smoking	0.3	0.5	2.5	0.1	1.1	1.0	-0.0	0.4	0.5	0.2	1.0	-0.8	0.2	0.3	0.2	1.6
Nervous feelings	0.3	0.6	2.5	-0.7	-0.1	-0.3	-0.3	-1.6	1.0	-0.3	0.1	0.6	-1.3	-0.5	-0.4	-1.2
Allergy	0.3	0.6	2.2	0.3	-1.2	-0.8	-0.7	0.7	0.4	-1.5	0.3	-0.5	1.3	-0.6	-0.0	-0.0
Medication: Ramipril	0.3	0.4	1.9	-1.4	0.2	0.3	0.2	0.3	1.1	-0.5	0.1	-0.7	0.8	0.2	-0.0	-0.2
Weight	0.3	1.7	4.0	0.5	0.5	1.6	1.4	2.0	0.6	1.6	1.6	0.5	1.6	1.7	1.5	-0.1
Impedance of arm (right)	0.3	1.5	10.5	0.2	0.7	-3.2	-0.0	-1.3	-1.4	0.5	0.4	1.2	-1.6	-0.3	-0.0	-0.4
Worrier / anxious feelings	0.3	0.6	2.8	0.0	-0.9	-0.5	-0.6	0.2	0.3	-1.7	0.7	1.0	-0.6	-0.4	-0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.8	-1.7	0.1	0.5	-0.4	-0.7	1.4	-0.3	0.2	-0.1	-0.4	0.0	-0.4	0.0
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	-0.8	-1.1	-1.1	0.1	-0.1	0.4	1.1	-0.3	-0.8	-0.2	0.2	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.8	1.2	0.3	0.1	-1.0	-1.4	-1.3	-0.3	0.7	0.4	-1.4	-0.6	-0.0	1.9
Noisy workplace	0.3	0.3	2.4	-0.1	1.5	0.7	-0.0	-0.0	0.4	0.8	0.4	-0.3	-0.6	0.3	-0.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.0	1.0	-0.9	1.4	0.1	0.5	-0.2	0.4	-0.3	0.2	0.0	-0.7	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.6	1.2	0.6	0.6	-0.1	-0.8	-1.6	0.2	1.1	0.6	-0.3	-0.1	0.6	1.9
Standing height	0.3	2.8	19.4	2.1	-0.8	-4.4	-0.9	-2.1	-1.5	0.1	-0.0	0.9	-0.9	-1.3	-0.6	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.2	1.8	-0.1	-0.5	-0.9	-1.8	-1.7	-0.5	0.2	0.3	-1.4	-1.0	-0.3	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.9	0.7	0.6	0.4	0.7	0.5	-0.5	1.4	0.9	1.1	-0.5	0.4	0.7	0.1
Number of children fathered	0.3	0.4	1.2	0.2	-0.3	-1.1	-0.7	-0.5	0.5	-0.9	-0.4	-0.8	-0.3	-0.5	-0.7	-0.0
Medication: Allopurinol	0.3	0.4	1.6	0.9	0.4	0.1	0.7	1.0	-0.3	0.3	-0.3	-0.2	1.2	0.6	0.4	-1.0
Alcohol intake frequency.	0.3	0.7	1.8	0.5	1.3	0.7	0.2	0.3	-1.2	1.0	1.3	0.7	-0.6	1.0	0.5	-0.3
Comparative height size at age 10	0.3	1.4	3.8	1.6	-1.0	-1.8	-0.6	-0.6	-1.5	-0.7	0.0	1.9	0.4	-1.3	-0.5	-1.4
Suffer from ‘nerves’	0.3	0.4	1.9	0.5	-0.2	-0.0	-0.2	-0.6	0.4	-0.5	0.9	1.4	-0.7	-0.2	-0.2	-0.9
Overall health rating	0.3	0.6	2.8	-0.1	-0.6	1.7	0.2	-0.4	0.2	0.9	0.2	1.5	-0.9	0.0	-0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.5	1.2	-0.0	0.2	0.5	-0.3	-0.7	0.7	1.0	0.3	0.7	0.5	0.6	0.9
Asthma (self-reported)	0.3	0.6	2.6	-1.0	0.6	1.3	1.0	0.3	0.4	1.6	-0.4	0.6	-0.2	0.7	0.4	-0.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.5	0.7	-0.6	0.4	-0.1	-0.5	-1.2	0.5	0.2	0.8	-0.5	-0.1	0.2	0.2
Leg fat percentage (left)	0.3	1.2	3.7	-1.2	-0.3	1.9	0.7	1.4	1.7	0.9	1.1	0.0	1.1	1.3	0.7	-0.5
Risk taking	0.3	0.5	1.6	0.0	-0.2	1.2	0.3	0.3	-1.1	0.6	-0.7	0.8	1.3	0.1	0.3	-0.6
Bipolar Disorder (2018)	0.2	0.3	1.1	0.8	0.0	-0.2	-0.2	-0.6	0.2	0.5	-0.1	-0.3	-0.8	-0.3	-0.5	-1.0
Worry (Nagel 2018)	0.2	0.5	2.4	0.3	-0.1	-0.2	-0.0	-0.2	0.2	-0.9	0.8	1.5	-1.4	0.0	0.1	-0.6
Reaction Time	0.2	0.4	1.0	-0.2	0.4	-0.8	-0.3	-0.9	0.0	-1.0	0.9	0.6	-0.9	0.0	0.2	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	1.1	0.5	0.1	-0.8	-0.3	-0.5	0.1	0.1	0.0	0.1	-1.0	-0.5	-0.4	-0.2
Triglycerides	0.2	0.3	1.4	-0.1	0.5	0.8	0.7	-0.4	0.2	1.2	-0.1	-0.1	-0.8	0.8	0.4	0.3
Heel T-Score	0.2	1.3	4.6	-0.5	0.4	0.9	1.4	2.1	0.2	1.3	0.4	0.7	1.4	1.3	1.6	0.1
Waist Hip Ratio (WHR)	0.2	0.9	3.0	-0.3	-1.6	0.3	0.4	0.4	-0.6	-1.3	-0.7	1.7	0.5	-0.2	-0.2	-1.7
Allergy or Eczema	0.2	0.5	2.4	0.2	0.5	-0.4	-0.2	-1.5	-0.4	-0.4	-0.8	0.1	-1.5	-0.5	-0.6	-0.2
Hair Pigment	0.2	7.0	11.9	-1.7	-2.7	-2.7	-3.2	-3.4	2.3	-1.4	-2.6	-1.6	-3.4	-3.1	-3.5	-1.6
Angina	0.2	0.2	1.0	0.3	0.5	0.9	-0.2	0.2	0.4	1.0	0.1	0.3	0.4	0.2	0.0	0.6
Number of incorrect matches in round	0.2	0.3	1.4	0.5	0.1	-0.5	0.4	-1.2	-0.1	0.7	0.4	0.4	-0.8	0.3	0.8	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	1.2	0.0	0.2	-0.3	-0.8	-0.1	0.2	-1.1	0.5	0.7	-0.5	-0.6	-0.1	0.5
Had menopause	0.2	0.3	1.7	0.0	-0.7	-0.7	-0.2	0.1	-0.4	-0.6	0.4	1.3	-0.2	-0.3	-0.2	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.2	0.2	-0.6	-0.7	0.4	0.4	0.1	0.3	-0.3	0.7	-0.7	-0.6	0.3
High blood pressure (siblings)	0.2	0.2	1.4	-0.0	-1.2	0.5	0.0	-0.5	0.7	-0.5	-0.3	-0.1	-0.5	-0.0	-0.4	0.0
Angina (self-reported)	0.2	0.2	0.8	0.4	0.8	0.8	-0.1	0.0	0.4	0.9	0.4	0.3	0.3	0.3	0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.4	-0.4	-0.3	0.7	-0.0	0.9	0.2	0.3	-0.8	-0.7	0.5	0.5	-0.2
Whole body fat-free mass	0.2	1.1	2.5	1.2	0.5	1.2	0.8	1.5	0.4	0.8	1.4	-0.0	1.6	1.0	1.1	0.5
Ever had bowel cancer screening	0.2	0.2	1.1	-0.0	-0.0	0.1	0.6	1.1	0.4	0.6	0.1	0.4	-0.2	0.3	0.2	0.1
Qualifications: nursing, teaching	0.2	0.4	2.6	-0.5	-0.2	0.5	-0.6	0.5	0.1	-1.6	-0.4	-0.3	0.7	-0.3	-0.4	0.4
Osteoporosis (self-reported)	0.2	0.2	0.7	0.3	0.8	-0.4	0.8	-0.1	-0.5	0.2	0.2	0.5	-0.1	0.4	0.4	-0.3
Whole body water mass	0.2	1.1	2.7	1.3	0.5	1.2	0.8	1.6	0.3	0.9	1.4	-0.1	1.6	1.1	1.2	0.4
Hearing aid user	0.2	0.2	1.0	0.3	1.0	-0.1	0.3	-0.2	0.3	-0.0	0.0	-0.3	-0.9	0.1	0.4	0.1
Ever smoked	0.2	0.3	1.2	-0.6	-0.6	0.0	0.5	-0.6	-0.2	0.1	-0.9	0.8	0.2	0.2	0.1	-1.1
Basal metabolic rate	0.2	1.3	2.9	1.1	0.6	1.3	0.9	1.7	0.4	1.0	1.6	0.2	1.7	1.2	1.3	0.5
Age started oral contraceptive pill	0.2	0.3	1.2	0.5	-0.1	-0.3	0.5	0.0	-0.4	-0.3	-0.2	0.8	-0.8	0.4	0.2	-1.1
Blood Platelet Count	0.1	0.7	3.2	-1.8	-0.0	0.1	-1.3	-0.2	1.1	-0.6	0.4	0.1	0.0	-0.8	-1.1	0.4
Respiratory disease	0.1	0.2	0.7	0.2	0.2	0.4	0.1	0.1	-0.1	0.8	-0.8	0.5	-0.6	0.0	-0.3	-0.9
Tanning	0.1	1.8	9.9	1.9	0.5	-0.2	1.1	-1.6	-3.1	1.1	0.2	1.9	0.1	0.0	1.1	-0.3
Trunk fat-free mass	0.1	0.8	2.5	1.6	0.3	0.5	0.4	1.2	-0.0	0.2	1.4	0.2	1.5	0.6	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.4	0.0	-0.0	1.2	0.7	0.2	0.2	0.4	-0.7	0.4	0.9	0.3	0.6	-0.3
Trunk predicted mass	0.1	0.8	2.4	1.4	0.3	0.5	0.3	1.2	0.0	0.1	1.4	0.2	1.5	0.5	0.9	1.0
Arm fat-free mass (right)	0.1	0.4	1.0	0.5	-0.4	1.0	0.1	0.8	0.9	0.5	0.3	-0.6	0.9	0.4	0.2	-0.4
Arm predicted mass (right)	0.1	0.6	1.6	0.5	-0.1	1.1	0.2	1.1	1.3	0.6	0.4	-0.9	0.9	0.6	0.3	-0.3
Medication for cholesterol	0.1	0.1	0.7	0.8	-0.1	-0.0	-0.0	-0.8	0.3	-0.4	0.1	-0.1	-0.5	0.1	0.2	0.2
Arm fat-free mass (left)	0.1	0.5	1.3	0.9	0.0	1.0	0.3	1.1	0.7	0.6	1.0	-0.4	1.2	0.5	0.6	0.0
Arm predicted mass (left)	0.1	0.5	1.5	0.6	-0.2	1.1	0.2	1.2	0.8	0.6	0.8	-0.4	1.2	0.4	0.4	-0.1

Hub : Genes

CA8

Models

Trait associations