Best TWAS P=8.44e-22 · Best GWAS P=3.3e-18 conditioned to 0.00358
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NDUFAF6 | 0.10 | 0.02 | lasso | 8 | 0.04 | 1.4e-04 | 8.3 | -7.1 | 1.3e-12 | -0.32 | 0.06 | 0.81 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CCNE2 | 0.16 | 0.08 | enet | 20 | 0.06 | 5.8e-04 | 8.3 | -8.2 | 3.1e-16 | -0.50 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Artery Aorta | TP53INP1 | 0.08 | 0.02 | enet | 18 | 0.03 | 9.7e-03 | -5.2 | 6.7 | 1.7e-11 | 0.71 | 0.08 | 0.80 | FALSE |
| 4 | GTEx | Artery Tibial | INTS8 | 0.11 | 0.11 | lasso | 1 | 0.09 | 7.1e-08 | 6.6 | -6.7 | 3.0e-11 | -0.35 | 0.96 | 0.02 | FALSE |
| 5 | GTEx | Brain Cerebellum | NDUFAF6 | 0.28 | 0.13 | lasso | 7 | 0.14 | 5.8e-05 | 8.3 | -8.3 | 7.6e-17 | -0.42 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | INTS8 | 0.27 | 0.26 | lasso | 3 | 0.24 | 1.9e-08 | 6.0 | 5.9 | 4.5e-09 | 0.56 | 0.96 | 0.01 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | NDUFAF6 | 0.07 | 0.03 | enet | 9 | 0.01 | 7.6e-02 | 8.3 | -9.6 | 8.4e-22 | -0.69 | 0.06 | 0.88 | TRUE |
| 8 | GTEx | Heart Atrial Appendage | NDUFAF6 | 0.17 | 0.03 | lasso | 6 | 0.04 | 6.7e-03 | -7.3 | -9.2 | 2.4e-20 | -0.63 | 0.10 | 0.49 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | CCNE2 | 0.13 | 0.15 | lasso | 4 | 0.15 | 4.2e-07 | 7.4 | -7.6 | 2.8e-14 | -0.48 | 0.46 | 0.30 | FALSE |
| 10 | GTEx | Heart Left Ventricle | NDUFAF6 | 0.10 | 0.05 | lasso | 11 | 0.07 | 1.6e-04 | 7.4 | -8.5 | 1.4e-17 | -0.78 | 0.22 | 0.69 | FALSE |
| 11 | GTEx | Ovary | NDUFAF6 | 0.24 | 0.12 | enet | 9 | 0.12 | 6.7e-04 | 4.1 | -5.8 | 6.7e-09 | -0.16 | 0.08 | 0.82 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | TP53INP1 | 0.09 | 0.06 | enet | 13 | 0.07 | 3.3e-06 | 8.3 | -7.5 | 7.9e-14 | -0.32 | 0.03 | 0.97 | FALSE |
| 13 | GTEx | Testis | TP53INP1 | 0.12 | 0.10 | enet | 13 | 0.04 | 6.1e-03 | 7.4 | -7.5 | 4.4e-14 | -0.40 | 0.04 | 0.94 | FALSE |
| 14 | GTEx | Testis | CCNE2 | 0.15 | 0.09 | lasso | 4 | 0.10 | 3.5e-05 | 7.3 | 5.3 | 1.4e-07 | 0.27 | 0.41 | 0.48 | FALSE |
| 15 | GTEx | Whole Blood | TP53INP1 | 0.07 | 0.04 | enet | 13 | 0.02 | 2.9e-03 | 8.3 | 7.2 | 4.7e-13 | 0.35 | 0.04 | 0.96 | FALSE |
| 16 | YFS | Blood | TP53INP1 | 0.03 | 0.02 | lasso | 5 | 0.02 | 8.0e-07 | 7.2 | 7.6 | 3.4e-14 | 0.45 | 0.13 | 0.87 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C8orf38 | 0.02 | 0.00 | blup | 127 | 0.01 | 4.0e-04 | 8.4 | -8.7 | 4.5e-18 | -0.80 | 0.03 | 0.85 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | C8orf38 | 0.10 | 0.03 | enet | 20 | 0.06 | 2.0e-04 | 7.4 | -6.0 | 1.8e-09 | -0.58 | 0.07 | 0.42 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C8orf38 | 0.07 | 0.04 | lasso | 8 | 0.04 | 5.1e-05 | 7.4 | -8.3 | 1.3e-16 | -0.88 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TP53INP1 | 0.04 | 0.05 | blup | 56 | 0.06 | 4.2e-07 | 8.3 | 8.6 | 1.2e-17 | 0.57 | 0.01 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C8orf38 | 0.06 | 0.04 | lasso | 1 | 0.04 | 7.0e-05 | 5.2 | -5.2 | 2.3e-07 | -0.41 | 0.18 | 0.25 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | C8orf38 | 0.03 | 0.02 | blup | 127 | 0.02 | 1.6e-03 | 5.2 | -7.9 | 3.2e-15 | -0.69 | 0.06 | 0.62 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C8orf38 | 0.11 | 0.12 | lasso | 4 | 0.11 | 1.8e-11 | 8.7 | -9.5 | 1.9e-21 | -0.98 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TP53INP1 | 0.06 | 0.02 | lasso | 3 | 0.03 | 2.8e-03 | 8.3 | 8.3 | 7.6e-17 | 0.43 | 0.01 | 0.97 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | C8orf38 | 0.12 | 0.04 | lasso | 3 | 0.08 | 8.3e-08 | 7.4 | -6.1 | 9.2e-10 | -0.70 | 0.31 | 0.67 | FALSE |