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chr10:64,195,778-66,034,105

Best TWAS P=1.11e-16 · Best GWAS P=1.95e-15 conditioned to 0.611

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	-7.8	-7.8	5.2e-15	0.98	0.02	0.98	FALSE
2	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	7.8	7.7	1.1e-14	-0.97	0.02	0.98	FALSE
3	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	-7.8	8.0	9.7e-16	-0.97	0.01	0.98	FALSE
4	GTEx	Cells Transformed fibroblasts	JMJD1C	0.09	0.01	enet	18	0.07	8.6e-06	5.7	5.2	2.0e-07	-0.62	0.13	0.68	FALSE
5	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	-7.9	6.8	7.5e-12	-0.97	0.01	0.99	FALSE
6	GTEx	Esophagus Muscularis	NRBF2	0.10	0.03	enet	22	0.03	3.8e-03	-5.0	7.4	1.4e-13	-0.72	0.02	0.96	FALSE
7	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	-7.9	8.3	1.1e-16	-0.94	0.01	0.99	TRUE
8	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	4.9	5.6	1.7e-08	-0.75	0.06	0.50	FALSE
9	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	-7.9	7.6	2.8e-14	-0.98	0.01	0.98	FALSE
10	GTEx	Thyroid	NRBF2	0.11	0.05	lasso	3	0.07	2.5e-06	3.9	7.3	2.1e-13	-0.73	0.03	0.96	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	-7.8	7.9	3.6e-15	-0.98	0.01	0.99	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	6.1	-6.5	7.3e-11	0.76	0.98	0.02	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBF2	0.07	0.04	blup	42	0.02	7.3e-03	-7.7	6.6	3.3e-11	-0.83	0.00	0.98	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	-7.8	7.8	4.4e-15	-0.97	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBF2	0.13	0.10	enet	11	0.09	4.9e-06	-7.8	7.4	1.2e-13	-0.82	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	-7.7	7.2	8.5e-13	-0.87	0.01	0.74	FALSE
17	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBF2	0.17	0.09	enet	10	0.13	1.1e-04	-7.8	6.8	7.8e-12	-0.87	0.00	0.95	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	-7.7	7.5	6.3e-14	-0.95	0.00	0.99	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	4.6	6.8	1.4e-11	-0.87	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NRBF2	0.08	0.01	blup	40	0.03	6.6e-03	4.6	5.4	7.1e-08	-0.60	0.01	0.43	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	-7.8	7.7	9.7e-15	-0.96	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	4.4	-7.2	4.5e-13	0.82	0.04	0.96	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	-7.7	8.2	3.6e-16	-0.92	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	2.9	5.5	5.1e-08	-0.72	0.07	0.89	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	-7.7	7.2	5.7e-13	-0.88	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	-7.8	6.1	1.2e-09	-0.87	0.00	0.90	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	-7.8	7.7	9.6e-15	-0.87	0.01	0.92	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	-7.7	7.6	2.2e-14	-0.97	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	-7.7	6.3	3.5e-10	-0.91	0.00	1.00	FALSE