Best TWAS P=2.07e-37 · Best GWAS P=8.29e-86 conditioned to 2.17e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AIFM2 | 0.26 | 0.26 | enet | 20 | 0.27 | 1.6e-32 | -4.9 | 5.2 | 2.1e-07 | -0.06 | 0.01 | 0.98 | FALSE |
| 2 | METSIM | Adipose | HK1 | 0.07 | 0.02 | lasso | 4 | 0.02 | 1.8e-03 | 12.7 | -12.8 | 2.1e-37 | -0.60 | 0.41 | 0.04 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HK1 | 0.04 | 0.02 | blup | 131 | 0.02 | 8.7e-05 | -5.6 | 5.7 | 1.3e-08 | -0.03 | 0.76 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TYSND1 | 0.03 | 0.04 | enet | 6 | 0.04 | 6.4e-05 | -5.1 | -5.2 | 1.5e-07 | 0.06 | 0.00 | 0.99 | TRUE |