TWAS
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Models
Genes
Traits
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Traits
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Blood Red Count
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chr10:70,332,066-72,574,945
Best TWAS P=2.07e-37 · Best GWAS P=8.29e-86 conditioned to 2.17e-23
70.5M
71M
71.5M
72M
72.5M
0
20
40
60
80
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
METSIM
Adipose
HK1
0.07
0.02
lasso
4
0.02
1.8e-03
12.7
-12.8
2.1e-37
-0.60
0.41
0.04
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
HK1
0.04
0.02
blup
131
0.02
8.7e-05
-5.6
5.7
1.3e-08
-0.03
0.76
0.00
TRUE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
TYSND1
0.03
0.04
enet
6
0.04
6.4e-05
-5.1
-5.2
1.5e-07
0.06
0.00
0.99
TRUE
1
CommonMind
Brain Pre-frontal Cortex
AIFM2
0.26
0.26
enet
20
0.27
1.6e-32
-4.9
5.2
2.1e-07
-0.06
0.01
0.98
FALSE