TWAS hub - JMJD1C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0940	0.0350	0.0002	0.009	NA	0.068	NA	0.047	0.064	NA	8.6e-06	NA	0.00018
2	TCGA	Glioblastoma Multiforme	0.1140	0.0660	0.0051	0.020	0.048	0.020	NA	-0.007	0.082	0.0140	7.8e-02	NA	0.57000
3	TCGA	Prostate Adenocarcinoma	0.0423	0.0267	0.0061	0.011	0.015	0.002	NA	0.009	0.024	0.0097	1.7e-01	NA	0.03900

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	56.0	649.0	882.1	-15.9	-28.5	-29.7
Blood White Count	24.6	182.3	210.2	11.5	14.3	14.5
Triglycerides	21.3	34.9	44.7	4.6	6.7	6.2
Qualifications: None of the above	17.5	37.5	52.6	6.1	7.2	4.8
Average weekly beer plus cider intake	14.3	20.7	24.5	3.9	4.7	4.9
Supplements: Zinc	12.2	13.3	16.1	-2.9	-3.9	-4.0
Impedance of arm (left)	11.4	52.9	64.3	-7.6	-8.0	-6.1
Qualifications: A levels/AS levels or equivalent	11.1	24.5	30.8	-4.8	-5.6	-4.4
Depression (Nagel 2018)	10.8	16.2	22.8	3.8	4.8	3.3
Exposure to tobacco smoke outside home	10.7	14.3	16.4	4.0	3.8	3.5
Impedance of arm (right)	10.6	49.5	59.4	-7.3	-7.7	-6.0
Average weekly red wine intake	10.4	15.3	24.4	-2.1	-4.1	-4.9
Pack years adult smoking proportion	10.3	15.7	23.5	4.5	4.9	1.9
Alcohol usually taken with meals	10.1	16.3	19.5	-3.4	-4.2	-4.4
HDL Cholesterol	10.0	16.7	22.9	-3.4	-4.8	-4.0
Lung FEV1/FVC ratio	10.0	50.5	57.2	7.1	7.6	6.6
Age at first live birth	9.7	17.1	21.5	-4.4	-4.6	-3.2
Frequency of unenthusiasm / disinterest in last 2 weeks	9.6	12.8	19.0	3.2	4.4	3.1
Pack years of smoking	9.1	13.3	19.5	4.2	4.4	1.6
Number of full sisters	9.0	10.9	12.4	3.4	3.0	3.5
Frequency of tiredness / lethargy in last 2 weeks	7.9	12.9	18.2	4.3	3.7	2.6
Frequency of tenseness / restlessness in last 2 weeks	7.5	11.6	15.1	3.6	3.9	2.6
Intelligence (Savage-Jansen 2018)	7.4	22.9	35.1	-4.6	-5.9	-3.5
High blood pressure (siblings)	7.4	10.7	13.7	2.5	3.4	3.7
Qualifications: College or University degree	7.4	23.5	30.5	-5.4	-5.5	-3.2
Diastolic blood pressure, automated reading	7.3	22.8	31.8	4.3	4.2	5.6
Qualifications: O levels/GCSEs or equivalent	7.2	11.4	17.2	-3.4	-4.1	-2.4
Age when periods started (menarche)	7.0	16.7	22.3	-3.0	-4.3	-4.7
Age at last live birth	6.9	10.0	12.5	-3.5	-3.0	-2.9
Qualifications: nursing, teaching	6.9	10.7	16.0	-4.0	-3.4	-2.1
Impedance of whole body	6.8	34.4	41.2	-6.2	-6.4	-4.8
Current tobacco smoking	6.1	10.1	16.6	3.2	4.1	1.9
Relative age voice broke	6.0	9.2	14.3	-2.9	-2.2	-3.8
Smoking status: Current	6.0	9.6	16.6	3.1	4.1	1.7
Deep venous thrombosis (DVT) (self-reported)	6.0	7.7	13.6	-2.0	-2.4	-3.7
Age at First Birth	5.9	8.6	12.0	-2.1	-3.5	-3.1
Body Mass Index (BMI) (2010)	5.9	8.1	9.3	2.4	3.1	3.0
Blood clot in the leg (DVT)	5.9	7.7	14.7	-1.6	-2.4	-3.8
Mineral and other dietary supplements	5.9	7.9	18.3	1.1	2.1	4.3
Verbal and Numeric Reasoning (VNR)	5.7	13.6	23.1	-3.8	-4.8	-1.7
Fluid intelligence score	5.7	11.9	19.3	-3.6	-4.4	-1.9
Medication: Ventolin 100micrograms inhaler	5.7	7.3	8.6	-2.9	-2.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.6	11.9	14.5	3.6	3.8	2.8
Body mass index (BMI)	5.5	23.6	26.0	4.8	4.6	5.1
Overall health rating	5.5	11.8	13.7	3.6	3.7	3.0
BMI	5.4	31.1	37.9	5.4	5.2	6.2
Frequency of depressed mood in last 2 weeks	5.2	7.2	11.5	2.7	3.4	1.7
Gout (self-reported)	5.1	6.9	11.8	2.0	2.2	3.4
Supplements: Glucosamine	5.0	6.5	11.7	-2.1	-1.9	-3.4
Pulse wave peak to peak time	4.9	5.7	8.4	-2.9	-2.5	-1.5
Blood Red Count	4.8	46.0	59.9	5.2	7.2	7.7
Relative age of first facial hair	4.8	9.8	17.3	-2.5	-2.4	-4.2
Multivitamins +/- minerals	4.8	6.1	12.3	-2.1	-1.3	-3.5
Illnesses of siblings	4.8	6.7	7.7	-2.8	-2.4	-2.6
Exposure to tobacco smoke at home	4.7	5.2	7.4	1.8	2.7	2.3
Respiratory disease	4.6	10.2	14.7	-2.8	-3.8	-2.8
Lung FVC	4.5	22.7	42.9	2.8	6.5	4.2
Qualifications: CSEs or equivalent	4.5	5.9	8.3	2.9	2.7	1.4
Supplements: Calcium	4.5	4.9	13.2	-0.6	-1.1	-3.6
Pulse wave reflection index	4.4	5.4	10.1	3.2	1.9	1.6
Allergy	4.3	10.0	10.6	3.2	3.3	3.0
Mother’s age at death	4.2	5.3	6.2	-2.5	-1.9	-2.5
Medication: Blood pressure	4.1	7.8	13.8	2.3	2.0	3.7
Loud music exposure frequency	3.9	4.3	9.0	1.8	3.0	0.8
Loneliness, isolation	3.9	5.3	8.4	2.9	2.6	0.8
Allergy or Eczema	3.8	10.1	13.4	-3.7	-3.3	-2.5
Noisy workplace	3.8	4.6	8.4	1.1	2.1	2.9
Pulse wave Arterial Stiffness index	3.8	4.4	7.3	2.7	2.2	1.1
Medication: Seretide 50 evohaler	3.8	4.4	6.1	-1.6	-2.5	-2.1
Leg fat percentage (left)	3.8	13.7	20.4	3.2	3.2	4.5
Smoking Status	3.7	8.8	13.0	3.1	3.6	2.0
Hypertension (Self-reported)	3.7	10.2	15.8	2.6	2.9	4.0
Depressed Affect (Nagel 2018)	3.6	7.6	9.1	3.0	2.9	2.3
Breast Cancer	3.6	8.7	14.1	-2.0	-3.8	-2.8
Falls in the last year	3.6	4.9	8.0	2.8	2.2	1.4
Medication: Allopurinol	3.6	4.8	6.7	2.6	1.1	2.6
Knee pain experienced in last month	3.6	5.6	9.0	2.5	3.0	1.2
Hearing aid user	3.6	4.0	4.5	1.8	2.1	2.0
Bilateral oophorectomy (both ovaries removed)	3.5	4.0	5.6	1.6	2.4	2.0
Leg fat percentage (right)	3.5	12.8	20.9	2.7	3.2	4.6
Vascular/heart problems diagnosed by doctor	3.5	9.5	14.5	-2.6	-2.7	-3.8
High blood pressure	3.4	9.6	17.2	2.2	2.6	4.2
Illnesses of father: High blood pressure	3.4	4.1	5.1	2.3	1.8	2.1
Hayfever, allergic rhinitis or eczema	3.3	7.3	8.3	-2.9	-2.8	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	4.7	-1.6	-2.1	-2.2
Unable to work because of sickness or disability	3.3	4.2	6.4	1.8	2.5	1.8
Waist circumference	3.2	11.7	13.3	3.1	3.5	3.6
Back pain experienced in last month	3.2	4.7	6.5	2.3	2.5	1.6
Number of full brothers	3.0	3.7	5.3	1.8	1.6	2.3
Mood swings	3.0	5.4	8.6	2.9	2.4	1.4
Supplements: Fish oil (including cod liver oil)	3.0	3.9	10.3	-0.6	-1.1	-3.2
Asthma (self-reported)	2.9	5.7	7.3	-2.2	-2.7	-2.2
Arm fat-free mass (left)	2.9	14.9	22.5	4.7	4.0	2.5
LDL Cholesterol	2.8	4.4	5.9	-2.4	-2.2	-1.5
Vitamin and mineral supplements	2.8	3.8	10.5	0.8	0.5	3.2
Medication: Metformin	2.8	3.9	10.2	0.3	1.2	3.2
Alzheimer’s Disease (in father)	2.7	2.9	4.1	1.6	2.0	1.5
Fasting Glucose	2.7	3.2	5.1	1.8	1.1	2.3
Cardiovascular Disease	2.7	9.0	14.3	2.9	2.1	3.8
Asthma	2.7	5.4	6.9	-2.3	-2.6	-2.0
Leg fat mass (right)	2.7	10.6	14.8	3.0	2.9	3.8
Leg fat mass (left)	2.7	10.4	14.0	3.1	2.8	3.7
Arm predicted mass (left)	2.7	13.8	19.8	4.4	3.9	2.5
Medication for cholesterol	2.6	4.0	6.6	-1.9	-1.3	-2.6
Miserableness	2.6	4.4	5.9	1.4	2.3	2.4
Ever had prostate specific antigen (PSA) test	2.6	3.0	6.6	-2.6	-0.9	-1.3
Height	2.5	47.6	77.3	-4.8	-6.5	-8.8
Hand grip strength (right)	2.5	6.7	9.8	2.3	3.1	2.3
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	6.1	-2.5	-1.1	-1.6
Major Depression (MDD)	2.4	2.9	5.0	0.6	2.2	1.8
Mouth/teeth dental problems: Dentures	2.4	4.1	7.0	1.7	2.6	1.6
Waist Hip Ratio (WHR)	2.3	10.4	16.8	2.2	4.1	3.1
Impedance of leg (right)	2.3	11.0	17.2	-4.1	-3.4	-2.1
Diabetes (self-reported)	2.3	3.6	9.9	0.6	0.7	3.1
Worry (Nagel 2018)	2.2	4.6	5.3	-2.3	-2.1	-2.0
Mean Putamen Volume	2.2	2.6	4.7	-0.8	-1.5	-2.2
Hearing difficulty/problems with background noise	2.2	3.6	4.8	2.2	2.1	1.2
Arm fat-free mass (right)	2.2	11.3	17.2	4.1	3.5	2.1
Pain type(s) experienced in last month: Hip pain	2.2	2.7	5.0	2.2	1.8	0.3
Medication: Lisinopril	2.2	2.9	5.1	1.6	1.0	2.3
Pain experienced in last month	2.2	3.7	6.8	-1.7	-2.6	-1.1
Time employed in main current job	2.1	2.4	3.7	1.0	1.9	1.6
Arm fat mass (right)	2.1	8.6	11.6	2.8	2.5	3.4
Medication for pain relief, constipation, heartburn	2.1	3.7	6.2	-2.5	-2.1	-0.5
Medication: Bendroflumethiazide	2.1	3.2	6.7	1.2	1.2	2.6
Impedance of leg (left)	2.0	9.7	12.6	-3.6	-3.3	-2.3
Standing height	2.0	20.3	31.8	-3.2	-4.4	-5.6
Migraine (self-reported)	2.0	2.5	3.5	-1.9	-1.3	-1.5
Arm predicted mass (right)	2.0	10.2	15.9	4.0	3.3	1.9
Family relationship satisfaction	2.0	2.5	3.1	-1.5	-1.5	-1.8
Arm fat mass (left)	2.0	8.1	11.0	2.8	2.4	3.3
Alzheimer’s Disease (including proxy)	1.9	2.8	4.4	1.1	2.1	1.7
High blood pressure (mother)	1.9	2.7	4.7	1.4	1.2	2.2
Number of children fathered	1.9	2.1	3.3	-1.8	-1.6	-0.7
Diabetes diagnosed by doctor	1.9	3.1	8.9	0.1	0.6	3.0
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	4.9	-1.7	-2.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.5	2.1	1.4	0.6
Reaction Time	1.8	3.5	4.7	2.2	2.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	10.7	1.8	3.3	1.9
Hearing difficulty/problems: Yes	1.7	2.5	3.9	1.1	1.6	2.0
Fed-up feelings	1.7	3.0	4.3	1.0	2.1	2.0
Hair/balding pattern: Pattern 3	1.6	2.4	5.3	-1.3	-2.3	-0.4
Length of working week for main job	1.6	1.7	2.7	1.6	1.4	0.8
Medication: Amlodipine	1.6	2.3	4.6	0.9	1.2	2.2
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.8	-0.0	0.8	2.2
Bipolar Disorder (2011)	1.5	1.4	3.9	-2.0	-0.5	-0.4
Hand grip strength (left)	1.5	3.9	7.6	1.3	2.8	1.6
Severe depression (siblings)	1.5	1.7	3.3	0.7	1.8	1.1
Arm fat percentage (right)	1.5	5.8	10.4	2.0	1.8	3.2
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.4	-1.2	-1.9	-0.6
Commuting to job workplace: Walk	1.5	1.6	2.5	-0.9	-1.2	-1.6
Number of incorrect matches in round	1.4	2.3	3.7	1.6	1.9	0.8
Hair/balding pattern: Pattern 2	1.4	1.8	3.0	1.7	1.1	1.0
Weight	1.4	6.8	9.5	3.1	2.4	2.3
Father’s age at death	1.4	1.9	2.1	-1.3	-1.3	-1.4
Comparative body size at age 10	1.4	3.7	4.9	1.7	2.2	1.9
Had major operations	1.4	1.7	2.3	0.9	1.5	1.4
Medication: Gliclazide	1.4	1.6	1.8	1.3	1.2	1.2
Irritability	1.4	2.3	3.9	0.7	2.0	1.6
Systolic Blood Pressure	1.3	6.3	11.7	2.5	1.1	3.4
Ever had hysterectomy (womb removed)	1.3	1.5	2.7	1.2	1.6	0.6
Townsend deprivation index at recruitment	1.3	1.8	3.2	1.8	1.4	0.5
Trunk fat-free mass	1.3	7.4	12.7	3.6	2.9	1.1
Trunk predicted mass	1.3	7.4	13.0	3.6	2.9	1.1
Medication: Paracetamol	1.3	2.1	3.8	2.0	1.5	-0.3
Eye problems/disorders: Cataract	1.3	1.5	2.9	-0.7	-1.1	1.7
Breast cancer (self-reported)	1.3	1.5	3.7	1.9	0.7	-0.6
Chronotype (morning person)	1.2	2.9	5.1	-0.0	-1.9	-2.3
Average weekly spirits intake	1.2	1.5	3.3	1.8	1.0	0.4
Systolic blood pressure, automated reading	1.2	3.6	7.8	1.6	0.7	2.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.5	1.0	2.1	1.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.8	-0.9	1.4	1.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	7.3	1.5	2.7	1.6
Lung cancer (father)	1.2	1.4	2.9	0.6	1.0	1.7
Neck or shoulder pain in last month	1.2	1.7	2.4	1.6	1.5	-0.5
Mean time to correctly identify matches	1.2	2.3	3.3	1.3	1.8	1.4
Suffer from ‘nerves’	1.2	1.8	2.4	-1.6	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	3.1	-1.4	-1.5	-1.8
Arm fat percentage (left)	1.2	4.9	9.6	1.7	1.5	3.1
Average weekly champagne plus white wine intake	1.2	1.6	2.9	-1.7	-1.0	-1.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	1.7	1.2	1.3	1.0
Basal metabolic rate	1.2	6.5	11.2	3.4	2.5	1.5
Financial difficulties in last 2 years	1.1	1.5	3.3	1.1	1.8	-0.1
Whole body fat-free mass	1.1	6.3	11.4	3.4	2.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.9	-0.9	-0.9	-1.4
Whole body water mass	1.1	6.3	11.4	3.4	2.5	1.1
Guilty feelings	1.1	1.7	2.7	0.8	1.6	1.3
Ever depressed for a whole week	1.1	1.4	1.8	1.0	1.4	1.1
Maternal smoking around birth	1.0	1.4	1.6	1.2	1.1	1.3
Medication: Lansoprazole	1.0	1.2	1.8	1.1	0.8	1.3
Breastfed as a baby	1.0	1.3	2.6	-0.5	-1.0	-1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	1.2	1.5	0.0
Fractured/broken bones in last 5 years	1.0	1.3	1.7	1.3	1.2	0.7
Cholesterol lowering medication	1.0	1.5	3.9	0.8	0.1	2.0
Heel T-Score	0.9	7.3	20.2	-0.8	1.1	4.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	0.4	1.0	1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	1.8	1.3	0.9	-0.8
Nervous feelings	0.9	1.6	1.9	-1.1	-1.4	-1.3
Whole body fat mass	0.9	3.7	5.9	1.8	1.4	2.4
Medication: Atorvastatin	0.9	1.1	1.4	1.2	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	0.2	0.8	1.6
Rheumatoid Arthritis	0.8	1.1	1.9	-1.4	-0.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.3	0.3	-0.3	2.1
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	1.5	1.0	0.2
Taking other prescription medications	0.8	1.2	3.1	-0.1	-0.8	-1.8
Stomach or abdominal pain in last month	0.8	1.0	2.6	-0.0	0.5	-1.6
Medication: Ramipril	0.8	1.0	2.2	1.5	0.8	0.4
Number of live births	0.8	1.1	1.5	0.9	1.1	1.2
Headache pain in last month	0.8	1.3	2.5	1.1	1.6	0.3
Glaucoma (self-reported)	0.8	0.9	1.8	-0.3	-1.3	-0.9
Body fat percentage	0.8	3.1	7.0	1.1	1.0	2.6
Eye problems/disorders: None of the above	0.8	1.0	2.8	-0.3	0.0	-1.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	1.4	0.7	0.6
Long-standing illness, disability or infirmity	0.8	1.2	2.6	-0.6	-0.7	-1.6
Blood Eosinophil Count	0.7	5.0	12.4	-1.6	0.3	3.5
Medication: Simvastatin	0.7	1.0	1.9	-0.8	-1.4	0.7
Neuroticism score	0.7	1.5	2.1	1.1	1.5	1.1
Happiness	0.7	0.8	2.3	-1.5	0.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.9	0.7	0.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.2	-0.8	1.5	0.5
Medication: Ibuprofen	0.7	0.8	1.3	1.1	0.4	-1.0
Osteoarthritis (self-reported)	0.7	0.9	2.1	-0.5	-1.4	-0.7
Commuting to job workplace: Cycle	0.7	0.9	1.3	-1.1	-0.6	-1.0
Myopia	0.7	1.1	2.7	-0.6	-1.6	-0.3
Heart disease (siblings)	0.7	0.8	1.6	-0.4	-1.3	-0.8
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	-0.9	0.6	-1.8
Lupus	0.6	1.0	1.5	-1.2	0.4	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.1	-0.8	-0.9	-1.1
Illnesses of mother	0.6	0.7	1.4	0.2	1.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.1	-1.0	-0.4
Medication: Blood pressure	0.6	1.1	1.9	1.1	0.6	1.4
Supplements: Vitamin C	0.6	0.7	1.7	1.3	0.2	-0.6
Ever had bowel cancer screening	0.6	0.7	1.4	-1.2	-0.4	0.7
Medication: Paracetamol	0.6	1.0	1.6	1.2	1.0	-0.5
Bipolar Disorder (2018)	0.5	0.8	1.3	-1.0	-0.1	-1.1
Schizophrenia (2018)	0.5	0.9	2.0	-0.3	0.8	-1.4
Alzheimer’s Disease (in mother)	0.5	0.5	0.7	0.6	0.8	0.8
Ovarian Cancer	0.5	0.6	1.5	1.2	0.3	0.5
Crohns Disease (2012)	0.5	0.8	1.9	-0.3	-1.4	-0.7
Tanning	0.5	5.6	8.5	-2.1	-2.9	-1.9
Medication: Co-codamol	0.5	0.6	1.0	1.0	0.4	0.7
Leg fat-free mass (left)	0.5	2.7	5.5	2.3	1.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.8	-0.3	1.0
Leg predicted mass (left)	0.5	2.7	5.5	2.3	1.4	0.9
Had other major operations	0.5	0.6	1.1	-0.5	-0.7	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	0.8	1.1	-0.1
Pain all over the body in last month	0.5	0.5	1.6	0.0	0.1	1.3
Hip circumference	0.5	2.2	4.2	2.1	1.0	1.1
Alcohol intake versus 10 years previously	0.5	0.7	0.9	0.7	0.9	0.9
Depression (self-reported)	0.5	0.5	1.0	-1.0	0.5	0.6
Worry too long after embarrassment	0.5	0.9	1.6	1.3	-0.0	1.1
Wheeze or whistling in the chest in last year	0.5	0.8	1.5	-0.9	-0.3	-1.2
Heart disease (mother)	0.5	0.7	1.7	-0.4	-1.3	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.0	-1.0	-0.6	0.4
Illnesses of siblings: Diabetes	0.5	0.6	0.8	0.9	-0.9	-0.4
Leg fat-free mass (right)	0.5	2.5	6.1	2.5	1.1	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	0.9	-0.7	-0.6	-0.9
Wears glasses or contact lenses	0.5	0.6	1.5	-0.4	-0.1	1.2
Number of operations (self-reported)	0.5	0.8	1.4	1.2	1.0	0.1
Age started oral contraceptive pill	0.5	0.6	1.0	-1.0	-0.9	-0.1
Coronary Artery Disease (CAD)	0.4	0.4	1.0	0.3	-0.5	-1.0
Schizophrenia (2014)	0.4	0.9	1.7	-0.1	1.0	-1.3
Angina	0.4	0.5	1.5	1.2	-0.1	-0.1
Diabetes (father)	0.4	0.4	0.7	-0.5	-0.8	0.6
Diabetes (mother)	0.4	0.5	0.9	0.4	-0.7	1.0
Sitting height	0.4	3.1	8.0	0.1	-1.2	-2.8
Trunk fat mass	0.4	1.5	3.2	1.0	0.7	1.8
Tense / ‘highly strung’	0.4	0.6	1.5	0.3	0.5	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	-0.9	-0.4	-0.9
Birth weight	0.4	1.0	2.4	-1.5	-0.7	-0.2
Health satisfaction	0.4	0.5	0.6	0.5	0.8	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.8	0.3	0.8
Angina (self-reported)	0.4	0.6	1.6	1.3	-0.1	-0.1
Medication: Aspirin	0.4	0.5	1.2	1.1	-0.2	0.4
Illnesses of father: Heart disease	0.4	0.5	1.0	0.2	0.6	1.0
Leg predicted mass (right)	0.4	2.3	5.6	2.4	1.0	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-0.0	-1.1	-0.5
High cholesterol (Self-reported)	0.4	0.8	2.2	-0.1	-0.2	1.5
Basal cell carcinoma (self-reported)	0.4	0.4	0.7	0.1	0.7	0.9
Alcohol drinker status: Previous	0.4	0.5	1.0	0.6	-1.0	-0.4
Neuroticism (Nagel 2018)	0.3	0.6	1.0	1.0	0.8	0.6
Ulcerative Colitis	0.3	0.4	0.6	-0.5	-0.5	-0.8
Hair Pigment	0.3	8.4	13.5	3.7	3.4	-0.3
Number of treatments/medications taken	0.3	0.5	1.1	1.1	0.6	-0.2
Trunk fat percentage	0.3	1.0	3.0	0.2	-0.0	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	0.7	1.2	0.5
Mouth/teeth dental problems	0.3	0.4	0.8	0.9	0.4	-0.5
Pulse rate	0.3	0.5	1.3	-0.3	-0.4	-1.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	-1.3	-0.8	0.0
Peak expiratory flow (PEF)	0.3	0.7	1.1	0.7	1.0	0.6
Medication: Omeprazole	0.3	0.4	1.1	-0.2	0.3	1.0
Comparative height size at age 10	0.3	1.7	2.6	1.6	1.3	1.0
Leg pain on walking	0.3	0.4	1.0	1.0	0.4	0.0
Smoking status: Previous	0.3	0.4	0.9	-1.0	-0.6	0.0
Osteoporosis (self-reported)	0.3	0.3	0.7	0.8	0.5	-0.2
Medication: Aspirin	0.3	0.4	1.0	1.0	-0.1	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	0.4	0.5
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.4	0.1	1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.7	0.5	0.3
Crohns Disease (2017)	0.2	0.5	0.8	-0.0	-0.9	-0.9
Irritable Bowel Disease (IBD)	0.2	0.6	1.0	-0.1	-0.9	-1.0
Neuroticism (2016)	0.2	0.3	0.6	0.5	0.8	-0.2
Hypothyroidism (self reported)	0.2	0.5	0.9	-1.0	-0.7	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	0.0	-0.6
Medication: Atenolol	0.2	0.2	0.5	0.3	-0.7	-0.1
Had menopause	0.2	0.2	0.4	-0.3	0.6	-0.4
Birth weight of first child	0.2	0.3	0.8	-0.9	0.2	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	2.5	-0.0	1.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.1	0.8	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.4	0.5	0.7	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.3	0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.1	-0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	-0.3	0.8	0.2
Financial situation satisfaction	0.2	0.2	0.4	-0.7	0.4	-0.4
Alcohol drinker status: Never	0.2	0.2	0.5	0.7	0.1	-0.4
Ever smoked	0.2	0.3	0.6	-0.8	-0.1	-0.5
Prostate Cancer	0.1	0.1	0.1	0.4	0.3	-0.3
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.2	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.1	-0.5	-0.4
Neuroticism	0.1	0.2	0.4	0.6	0.4	0.2
Sensitivity / hurt feelings	0.1	0.1	0.1	0.3	0.3	-0.4
Average weekly fortified wine intake	0.1	0.2	0.4	0.6	0.2	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.5	-0.1	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.4	-0.0	0.7
Forced vital capacity (FVC)	0.1	0.5	1.3	-0.4	1.1	0.1
Heart attack	0.1	0.1	0.1	0.3	-0.4	0.3
Worrier / anxious feelings	0.1	0.1	0.2	-0.5	0.1	0.3
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.1	-0.7	0.2
Prospective memory result	0.1	0.2	0.2	-0.4	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.6	-0.4	0.4
Pulse rate, automated reading	0.1	0.3	0.6	-0.2	-0.8	-0.5
Alcohol intake frequency.	0.1	0.3	0.6	0.7	0.3	-0.4
Chest pain or discomfort	0.1	0.1	0.3	0.2	0.5	0.1
Friendships satisfaction	0.1	0.1	0.3	0.3	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.1	-0.4	0.4
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.0	-0.5	-0.1
HbA1C	0.0	0.1	0.1	-0.0	0.2	0.4
Past tobacco smoking	0.0	0.1	0.1	0.3	-0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.0	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.1	0.3	0.1
Risk taking	0.0	0.1	0.1	0.2	0.2	-0.4

Hub : Genes

JMJD1C

Models

Trait associations