Best TWAS P=1.55e-10 · Best GWAS P=1.05e-10 conditioned to 0.0173
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RP11-750H9.5 | 0.17 | 0.25 | lasso | 6 | 0.21 | 3.5e-06 | -6.3 | 6.3 | 2.1e-10 | -0.99 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | NUP160 | 0.18 | 0.02 | enet | 18 | 0.11 | 7.1e-05 | -3.9 | 6.4 | 1.6e-10 | -0.77 | 0.03 | 0.90 | TRUE |
| 3 | GTEx | Esophagus Muscularis | MTCH2 | 0.09 | 0.04 | lasso | 6 | 0.02 | 1.8e-02 | 3.7 | 5.4 | 7.4e-08 | -0.74 | 0.14 | 0.76 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MYBPC3 | 0.02 | 0.01 | blup | 43 | 0.01 | 3.4e-03 | 4.9 | -5.9 | 4.0e-09 | 0.67 | 0.18 | 0.20 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSMC3 | 0.09 | 0.05 | blup | 39 | 0.05 | 1.0e-03 | -6.3 | 6.1 | 1.2e-09 | -0.81 | 0.01 | 0.84 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MYBPC3 | 0.05 | 0.03 | blup | 43 | 0.04 | 6.0e-05 | 3.6 | -5.6 | 1.7e-08 | 0.50 | 0.59 | 0.28 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSMC3 | 0.05 | 0.01 | lasso | 3 | 0.02 | 9.4e-04 | -4.1 | 5.9 | 3.6e-09 | -0.56 | 0.03 | 0.09 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | MYBPC3 | 0.04 | 0.02 | enet | 10 | 0.04 | 2.9e-05 | 4.9 | -5.2 | 1.6e-07 | 0.33 | 0.28 | 0.06 | FALSE |