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chr11:56,742,853-58,178,587

Best TWAS P=6.27e-10 · Best GWAS P=1.74e-09 conditioned to 0.273

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Heart Atrial Appendage	MED19	0.11	0.14	lasso	1	0.14	6.0e-07	5.9	-5.9	3.2e-09	-0.97	0.01	0.99	FALSE
2	GTEx	Pancreas	MED19	0.10	0.08	lasso	3	0.02	5.0e-02	6.0	-6.0	2.1e-09	-0.99	0.01	0.90	FALSE
3	GTEx	Skin Sun Exposed Lower leg	MED19	0.15	0.11	lasso	7	0.09	1.3e-07	5.9	-5.6	2.1e-08	-0.98	0.01	0.99	FALSE
4	GTEx	Stomach	MED19	0.10	0.04	lasso	7	0.09	6.8e-05	5.8	-6.2	6.3e-10	-0.90	0.02	0.90	TRUE
5	GTEx	Vagina	MED19	0.26	0.03	lasso	10	0.06	1.5e-02	-2.5	-5.5	4.2e-08	-0.65	0.03	0.75	FALSE
6	YFS	Blood	ZDHHC5	0.06	0.07	enet	20	0.07	1.2e-22	5.9	6.0	1.7e-09	0.96	0.01	0.99	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED19	0.07	0.01	blup	26	0.05	7.4e-05	-4.2	-5.8	8.3e-09	-0.74	0.03	0.88	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED19	0.05	0.03	enet	7	0.05	1.3e-10	5.8	-6.1	1.1e-09	-0.84	0.01	0.99	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	TMX2	0.07	0.06	lasso	1	0.05	5.0e-04	5.9	5.9	2.9e-09	0.99	0.00	0.91	FALSE
10	The Cancer Genome Atlas	Esophageal Carcinoma	MED19	0.10	0.06	lasso	4	0.02	5.4e-02	6.0	-6.0	1.7e-09	-1.00	0.00	0.85	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED19	0.03	0.01	lasso	2	0.02	1.9e-03	5.8	-5.8	7.1e-09	-0.81	0.01	0.65	FALSE
12	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MED19	0.09	0.05	lasso	2	0.07	9.2e-05	-4.2	-5.6	1.7e-08	-0.72	0.03	0.81	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	MED19	0.05	0.02	blup	26	0.03	6.0e-05	5.9	-6.1	1.2e-09	-0.85	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED19	0.03	0.02	lasso	1	0.01	1.8e-02	5.9	-5.9	3.2e-09	-0.97	0.00	0.86	FALSE
15	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED19	0.13	0.06	blup	26	0.13	4.7e-06	-4.2	-5.8	8.4e-09	-0.75	0.05	0.82	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED19	0.07	0.05	blup	26	0.05	4.4e-06	-4.2	-5.4	7.4e-08	-0.68	0.44	0.50	FALSE
17	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED19	0.10	0.04	blup	26	0.03	3.6e-02	-4.2	-5.4	6.9e-08	-0.67	0.02	0.38	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	MED19	0.10	0.05	blup	26	0.09	3.8e-09	-4.2	-5.7	9.4e-09	-0.77	0.08	0.92	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	SERPING1	0.06	0.03	blup	52	0.04	6.3e-05	4.8	-5.2	2.7e-07	-0.69	0.06	0.86	FALSE