Best TWAS P=1.09e-22 · Best GWAS P=1.09e-22 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | PHGDH | 0.12 | 0.01 | enet | 24 | 0.03 | 4.6e-03 | 7.4 | -7.8 | 5.6e-15 | 0.23 | 0.20 | 0.20 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ZNF697 | 0.14 | 0.03 | lasso | 9 | 0.07 | 1.5e-05 | 5.0 | -5.4 | 7.7e-08 | 0.08 | 0.47 | 0.03 | FALSE |
| 3 | GTEx | Muscle Skeletal | ZNF697 | 0.13 | 0.02 | enet | 41 | 0.05 | 1.7e-05 | 4.9 | -6.2 | 7.2e-10 | 0.21 | 0.22 | 0.13 | TRUE |
| 4 | GTEx | Testis | PHGDH | 0.31 | 0.34 | lasso | 1 | 0.33 | 2.0e-15 | -9.8 | 9.8 | 1.1e-22 | -1.00 | 0.00 | 1.00 | TRUE |
| 5 | NTR | Blood | ZNF697 | 0.04 | 0.02 | bslmm | 363 | 0.02 | 2.3e-08 | -2.6 | -5.6 | 2.7e-08 | 0.43 | 0.94 | 0.04 | FALSE |
| 6 | YFS | Blood | PHGDH | 0.27 | 0.10 | enet | 56 | 0.17 | 6.9e-53 | 3.9 | 5.2 | 2.0e-07 | -0.30 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | ZNF697 | 0.02 | 0.00 | enet | 12 | 0.01 | 1.8e-04 | 7.3 | -8.1 | 5.4e-16 | 0.23 | 0.55 | 0.01 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF697 | 0.08 | 0.07 | blup | 55 | 0.08 | 1.7e-09 | 8.5 | -8.5 | 1.7e-17 | 0.33 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF697 | 0.07 | 0.02 | blup | 56 | 0.06 | 2.7e-07 | 7.3 | -6.3 | 2.2e-10 | 0.16 | 0.39 | 0.58 | TRUE |