Best TWAS P=7.48e-11 · Best GWAS P=4.72e-10 conditioned to 0.132
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | TMED8 | 0.15 | 0.03 | lasso | 6 | 0.06 | 3.8e-03 | 5.2 | 5.3 | 1.0e-07 | 0.04 | 0.06 | 0.78 | TRUE |
| 2 | GTEx | Nerve Tibial | GPATCH2L | 0.22 | 0.12 | enet | 8 | 0.15 | 5.3e-11 | -5.2 | -5.8 | 5.4e-09 | 0.56 | 0.25 | 0.75 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | GPATCH2L | 0.24 | 0.08 | lasso | 7 | 0.11 | 2.1e-06 | -5.2 | -5.7 | 1.5e-08 | 0.63 | 0.21 | 0.77 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | GPATCH2L | 0.27 | 0.18 | enet | 16 | 0.23 | 5.2e-19 | -6.2 | -6.5 | 7.5e-11 | 0.88 | 0.00 | 1.00 | TRUE |
| 5 | METSIM | Adipose | GPATCH2L | 0.12 | 0.12 | lasso | 7 | 0.11 | 3.4e-16 | -5.7 | -5.4 | 5.8e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMED8 | 0.02 | 0.01 | lasso | 2 | 0.00 | 5.5e-02 | 5.2 | 5.2 | 1.7e-07 | 0.05 | 0.01 | 0.89 | FALSE |