TWAS hub - GPATCH2L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.332	0.1100	5.0e-03	0.167	NA	0.086	NA	0.133	4.1e-06	NA	9.2e-04	NA	4.2e-05
2	GTEx	Cells Transformed fibroblasts	0.175	0.0530	5.9e-05	0.164	NA	0.141	NA	0.148	2.6e-12	NA	9.6e-11	NA	3.2e-11
3	GTEx	Nerve Tibial	0.219	0.0558	8.9e-05	0.117	NA	0.153	NA	0.152	1.3e-08	NA	5.3e-11	NA	6.4e-11
4	GTEx	Skin Not Sun Exposed Suprapubic	0.244	0.0720	1.8e-03	0.077	NA	0.058	NA	0.106	5.1e-05	NA	4.0e-04	NA	2.1e-06
5	GTEx	Skin Sun Exposed Lower leg	0.273	0.0480	7.2e-11	0.176	NA	0.231	NA	0.126	1.8e-14	NA	5.2e-19	NA	1.5e-10
6	METSIM	Adipose	0.120	0.0272	4.1e-13	0.123	0.102	0.110	0.109	0.111	7.2e-18	5.2e-15	4.7e-16	6.4e-16	3.4e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Ever had hysterectomy (womb removed)	6.3	7.1	11.0	-0.7	3.3	1.8	2.7	3.1	3.3
Lung FEV1/FVC ratio	6.1	30.8	46.0	-2.7	6.6	4.4	5.5	6.8	6.1
Fasting Glucose	5.8	7.0	12.0	1.8	-2.9	-2.0	-2.4	-2.9	-3.5
Severe depression (siblings)	5.4	6.1	10.5	-1.8	2.6	1.8	2.0	2.9	3.2
Alzheimer’s Disease (in mother)	4.5	5.3	10.3	1.4	-2.1	-2.2	-2.1	-3.2	-2.4
Mouth/teeth dental problems: Loose teeth	4.5	5.3	8.2	1.5	-2.0	-2.2	-2.4	-2.7	-2.9
Happiness	3.9	4.7	7.9	0.1	-2.6	-2.2	-1.8	-2.4	-2.8
Supplements: Calcium	3.9	4.3	8.1	-1.6	-1.5	-2.9	-2.4	-2.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.1	11.4	-2.3	2.7	2.4	3.0	3.4	3.1
Eye problems/disorders: None of the above	3.5	4.0	7.0	0.3	-2.6	-1.6	-1.5	-2.4	-2.5
Blood Red Count	2.9	27.7	42.4	1.8	-5.0	-5.8	-5.7	-6.5	-5.4
Pulse wave Arterial Stiffness index	2.8	3.2	7.7	2.8	-1.4	-0.5	-1.2	-2.0	-2.1
Supplements: Vitamin C	2.7	3.1	8.4	-0.4	2.9	1.1	0.8	1.7	2.4
Verbal and Numeric Reasoning (VNR)	2.6	6.2	10.5	0.6	-1.5	-3.0	-3.2	-3.1	-2.3
Average weekly fortified wine intake	2.6	3.0	5.0	-0.4	1.9	1.4	2.2	1.9	1.9
Risk taking	2.6	3.8	6.2	1.5	-1.4	-1.8	-1.9	-2.4	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.8	12.9	-2.4	3.6	1.4	2.8	3.1	2.9
Osteoporosis (self-reported)	2.4	2.9	7.6	-0.6	-2.8	-1.2	-1.0	-1.6	-2.1
Forced expiratory volume in 1-second (FEV1)	2.2	7.6	10.3	-3.1	3.2	1.1	2.6	3.0	2.9
Prospective memory result	2.2	2.7	5.4	-0.8	1.4	1.5	1.3	2.1	2.3
Falls in the last year	2.1	2.9	5.1	1.1	2.3	1.8	1.8	1.3	1.6
Birth weight of first child	2.1	3.9	7.3	-0.9	-1.5	-2.5	-2.7	-2.1	-1.5
Pulse wave peak to peak time	2.1	2.5	7.4	-2.7	1.0	0.1	0.9	1.6	1.7
Handedness (chirality/laterality): Left-handed	2.1	2.6	3.7	-0.8	-1.6	-1.6	-1.5	-1.9	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	5.2	-0.0	-1.2	-2.3	-1.8	-2.0	-1.5
Blood clot in the leg (DVT)	1.9	2.5	4.9	0.2	-1.0	-2.2	-1.7	-1.9	-1.5
Medication: Lisinopril	1.9	2.4	4.5	-0.7	0.5	2.1	1.8	1.8	1.7
Medication: Seretide 50 evohaler	1.8	2.1	3.3	-1.1	1.8	1.1	1.5	1.6	1.4
Mean time to correctly identify matches	1.8	3.4	5.7	-0.3	2.3	1.7	1.6	2.0	2.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.8	-1.5	2.2	0.4	0.6	1.2	2.0
Supplements: Zinc	1.7	1.9	5.6	-2.4	-0.5	-1.6	-1.5	-0.8	0.0
High blood pressure (siblings)	1.7	2.4	4.8	-1.6	2.2	0.3	0.8	1.6	2.0
Multivitamins +/- minerals	1.6	2.0	3.7	-1.9	1.0	1.0	1.4	1.6	1.4
Medication: Atenolol	1.6	1.9	4.2	0.8	0.6	2.1	1.7	1.5	1.1
Number of incorrect matches in round	1.6	2.6	4.0	-1.1	1.1	1.7	1.9	2.0	1.5
Breastfed as a baby	1.6	2.0	3.1	-1.8	0.2	1.1	1.7	1.5	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	4.1	-1.8	1.8	0.6	0.7	1.8	2.0
Chest pain or discomfort	1.6	2.3	3.8	1.6	1.4	2.0	1.2	1.6	1.3
Commuting to job workplace: Walk	1.6	1.7	2.5	0.7	-1.6	-0.9	-1.2	-1.5	-1.6
Illnesses of father: None of the above (group 1)	1.6	2.0	3.5	-1.4	1.2	0.9	1.4	1.9	1.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.1	-0.6	-1.2	-1.5	-1.8	-1.5	-1.5
HDL Cholesterol	1.5	2.6	6.1	0.1	2.5	1.2	1.0	1.8	1.9
Schizophrenia (2014)	1.5	3.4	16.3	-4.0	0.7	-0.7	0.8	1.1	1.1
Alcohol intake versus 10 years previously	1.5	2.3	3.5	0.9	-1.3	-1.6	-1.9	-1.5	-1.7
Medication: Gliclazide	1.5	1.6	4.6	-0.6	-0.2	-1.9	-2.2	-1.0	-0.2
HbA1C	1.4	1.6	3.6	1.9	0.8	1.7	1.1	0.9	0.6
Diabetes (mother)	1.4	1.8	4.2	-0.4	1.7	0.6	1.1	1.5	2.1
High blood pressure	1.4	3.8	7.9	1.4	0.9	2.8	2.4	1.9	1.7
Chronic bronchitis/emphysema (father)	1.4	1.7	2.8	-0.5	-1.2	-1.5	-1.3	-1.7	-1.1
Peak expiratory flow (PEF)	1.4	3.3	11.3	-3.4	1.0	0.3	1.1	2.1	1.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.9	-0.8	-1.3	-1.7	-1.2	-1.3	-1.4
Breast cancer (self-reported)	1.4	1.7	7.1	2.7	-0.7	0.9	0.3	-0.4	-1.2
Ever depressed for a whole week	1.4	1.7	3.2	-1.6	1.8	0.2	0.6	1.4	1.5
Vascular/heart problems diagnosed by doctor	1.4	3.7	7.4	-1.7	-1.3	-2.7	-2.1	-1.6	-1.9
Bipolar Disorder or Schizophrenia	1.3	3.2	16.1	-4.0	-0.2	-1.6	-0.3	0.3	0.7
Chronotype (morning person)	1.3	2.9	5.6	2.0	-2.4	0.6	-1.1	-1.3	-2.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.7	-2.2	0.8	-1.6	-1.0	-0.1	0.9
Pain all over the body in last month	1.3	1.4	3.9	0.4	2.0	0.5	0.4	1.0	1.7
Eye problems/disorders: Cataract	1.3	1.6	3.2	-1.0	1.8	0.3	0.5	1.4	1.7
Medication: Aspirin	1.3	1.7	6.2	2.5	-0.8	1.2	0.6	-0.7	-1.0
Medication: Blood pressure	1.3	2.6	4.4	0.8	1.8	2.1	1.6	1.8	1.2
Alcohol drinker status: Never	1.3	1.6	5.2	1.3	2.3	1.1	0.5	0.9	0.8
Schizophrenia (2018)	1.2	2.6	13.2	-3.6	0.0	-1.3	-0.0	0.3	0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.9	2.0	0.8	1.3	1.0	0.7	0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.7	0.7	0.4	1.9	1.6	1.1	0.6
Had other major operations	1.2	1.4	3.0	-1.5	0.9	0.5	0.7	1.4	1.7
Mouth/teeth dental problems	1.2	1.8	3.1	-1.6	0.9	0.8	1.3	1.4	1.8
Ever highly irritable/argumentative for 2 days	1.2	1.4	5.3	-2.3	1.0	-0.6	-0.0	1.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.9	-2.0	1.0	-1.6	-1.4	-0.1	0.5
Medication: Aspirin	1.2	1.5	6.6	2.6	-0.4	1.2	0.6	-0.5	-0.7
Allergy or Eczema	1.1	3.0	6.4	-0.6	2.5	1.4	1.3	1.4	2.3
Maternal smoking around birth	1.1	1.7	3.6	-0.6	0.1	-1.9	-1.9	-1.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	3.5	-0.7	1.9	0.8	0.9	1.5	1.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.7	0.2	-0.9	-1.3	-1.7	-1.3	-1.5
Illnesses of siblings	1.1	1.6	2.9	1.6	-1.1	-0.5	-0.7	-1.5	-1.7
Exposure to tobacco smoke at home	1.1	1.2	2.2	-0.4	0.6	1.2	1.2	1.3	1.5
Hypertension (Self-reported)	1.1	3.0	6.3	1.4	0.7	2.5	2.1	1.6	1.5
Illnesses of siblings: Diabetes	1.1	1.3	4.5	-0.7	1.2	0.3	0.2	1.1	2.1
Hypothyroidism (self reported)	1.0	2.2	3.4	-1.4	1.8	0.9	1.0	1.8	1.7
Hand grip strength (left)	1.0	2.5	11.9	-3.4	0.6	-1.1	-0.2	1.0	0.8
Vitamin and mineral supplements	1.0	1.3	2.3	1.5	-1.4	-0.6	-0.4	-0.9	-1.5
Alcohol usually taken with meals	1.0	1.6	4.8	2.2	0.7	-0.8	-1.1	-0.9	-1.2
Qualifications: None of the above	1.0	2.1	4.6	0.1	0.4	2.1	1.7	1.9	1.3
Number of children fathered	1.0	1.2	1.9	1.0	1.4	1.2	0.5	0.8	1.4
Emphysema/chronic bronchitis	1.0	1.1	3.4	1.9	-0.5	-0.1	-1.1	-1.0	-0.6
Migraine (self-reported)	1.0	1.2	3.2	-1.1	1.8	-0.5	-0.3	0.7	1.5
Medication: Atorvastatin	1.0	1.3	6.2	2.5	0.5	0.1	-0.2	-0.9	-0.6
Basal cell carcinoma (self-reported)	1.0	1.2	5.7	-2.4	0.4	-0.3	0.3	0.7	0.7
Neuroticism (2016)	0.9	1.3	1.9	-0.8	1.4	1.1	1.2	1.2	1.1
Medication: Metformin	0.9	1.3	4.2	1.2	2.1	0.7	0.4	0.5	1.1
Relative age voice broke	0.9	1.4	4.3	-0.9	1.5	-0.1	-0.3	1.0	2.1
Sitting height	0.9	6.5	15.8	-1.8	-1.9	-4.0	-2.3	-3.0	-1.5
Fluid intelligence score	0.9	1.8	3.3	0.9	0.1	-1.6	-1.8	-1.8	-1.1
Pulse rate	0.9	1.5	2.6	0.6	-1.6	-0.9	-1.2	-1.5	-1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.7	1.0	-1.1	-0.7	-0.7	-1.2	-1.6
Medication: Amlodipine	0.9	1.3	2.8	1.0	-1.7	-0.6	-0.2	-1.3	-1.3
Forced vital capacity (FVC), Best measure	0.9	3.2	4.7	-2.2	2.0	0.5	1.9	1.7	1.8
Exposure to tobacco smoke outside home	0.9	1.3	4.2	-2.1	1.3	0.1	0.6	0.8	0.8
Medication: Blood pressure	0.9	1.6	3.1	1.6	0.5	1.8	1.2	0.7	1.2
Medication: Bendroflumethiazide	0.9	1.4	3.2	0.7	0.9	1.8	1.4	1.1	1.0
Unable to work because of sickness or disability	0.9	1.1	5.2	2.3	-0.7	0.5	-0.2	-0.4	-0.7
Myopia	0.9	1.4	3.4	-0.5	-0.4	-1.8	-1.5	-1.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.5	0.3	0.4	1.6	0.5	1.1	1.5
Schizophrenia vs Biploar Disorder	0.8	1.0	1.5	0.1	1.1	1.2	1.1	1.2	0.8
Age at First Birth	0.8	1.1	1.9	-0.2	-0.8	-1.3	-1.2	-1.4	-1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.1	1.5	-1.3	-0.4	-0.9	-0.9	-0.6
Triglycerides	0.8	1.2	2.2	0.7	-1.5	-0.8	-0.4	-1.3	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	0.5	1.4	0.9	0.8	1.0	0.7
Respiratory disease	0.8	1.9	4.5	0.3	2.1	1.2	0.9	1.1	1.8
Leg fat-free mass (left)	0.8	4.4	9.3	-0.7	-1.3	-3.0	-2.4	-2.6	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	1.0	0.5	1.2	1.4	0.6	0.6
Leg predicted mass (left)	0.8	4.2	8.9	-0.6	-1.3	-3.0	-2.4	-2.6	-1.4
Number of live births	0.8	1.1	2.0	-1.4	0.9	0.5	0.9	1.0	1.2
Medication: Ibuprofen	0.8	1.0	2.4	1.5	-0.8	-0.2	-0.6	-1.1	-1.1
Leg pain on walking	0.8	0.9	1.5	1.2	-0.0	-1.0	-1.1	-1.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.1	-1.6	-0.4	-2.2	-0.7	-1.0	-0.9
Arm fat mass (left)	0.8	3.3	5.5	1.3	-1.4	-1.8	-2.3	-2.3	-1.5
Commuting to job workplace: Public transport	0.8	0.9	1.8	0.8	-0.6	-1.0	-1.4	-1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.5	0.5	0.9	1.2	0.6	1.1	1.6
Commuting to job workplace: Cycle	0.8	1.0	1.8	-0.9	0.6	0.8	1.0	1.3	1.2
Reaction Time	0.7	1.4	3.1	-0.5	1.8	0.9	0.8	1.2	1.5
Crohns Disease (2012)	0.7	1.2	2.9	-1.7	0.1	0.9	1.1	1.2	0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.1	1.4	0.7	1.4	1.4	1.0	0.7
Medication for hormone replacement therapy	0.7	0.7	1.4	-0.5	-1.0	-1.2	-0.7	-0.8	-0.7
Taking other prescription medications	0.7	1.0	1.8	0.3	1.2	1.3	0.3	1.0	1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	1.3	-1.0	0.3	0.7	-0.5	-1.2
Medication: Levothyroxine sodium	0.7	1.2	2.3	0.1	1.0	1.5	0.9	1.5	1.1
Trunk fat mass	0.7	3.0	4.4	1.9	-1.3	-1.5	-1.9	-2.1	-1.4
Past tobacco smoking	0.7	1.3	3.4	1.0	-0.2	1.8	1.2	1.3	0.4
Medication: Ramipril	0.7	0.9	1.8	0.1	1.4	0.5	0.9	0.8	1.3
Weight	0.7	3.5	6.1	0.3	-1.3	-2.5	-2.4	-2.4	-1.2
Medication: Cholesterol lowering	0.7	1.0	4.0	2.0	0.7	1.0	0.8	-0.1	0.2
Arm fat mass (right)	0.7	2.7	4.8	1.3	-1.3	-1.5	-2.2	-2.1	-1.3
Standing height	0.7	7.4	22.1	-2.0	-1.6	-4.7	-2.4	-2.7	-1.7
Pulse wave reflection index	0.7	0.8	4.3	2.1	0.6	0.3	-0.1	-0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.8	-1.4	0.3	-1.7	-0.9	-0.9	-0.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.4	0.4	-1.5	-0.8	-1.4	-1.3	-0.8
Leg fat-free mass (right)	0.7	3.8	8.6	-1.0	-1.2	-2.9	-2.1	-2.4	-1.2
Mood swings	0.7	1.2	4.1	-2.0	-0.1	-1.3	-1.1	-0.4	-0.0
Whole body water mass	0.7	3.8	9.1	-1.4	-1.1	-3.0	-2.1	-2.3	-0.9
Leg predicted mass (right)	0.7	3.7	8.4	-0.9	-1.2	-2.9	-2.1	-2.4	-1.2
Guilty feelings	0.7	1.0	2.8	-1.7	-0.4	-1.4	-1.0	-0.5	-0.5
Mother’s age at death	0.7	0.9	2.9	1.7	-0.7	-0.1	-0.4	-0.8	-1.2
High cholesterol (Self-reported)	0.7	1.2	2.3	1.5	-0.9	-0.5	-1.0	-1.0	-1.3
Ever smoked	0.7	1.3	3.0	-1.7	0.4	-1.7	-1.0	-0.8	-0.4
Basal metabolic rate	0.7	4.0	9.0	-1.1	-1.3	-3.0	-2.3	-2.4	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	1.3	-0.7	-0.0	-1.2	-0.9	-0.6
Alcohol drinker status: Previous	0.7	0.8	1.3	-0.0	-0.9	-1.1	-1.1	-0.6	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	4.6	-2.1	-0.5	-1.3	-0.7	-0.4	0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	1.9	1.1	-0.1	-0.9	-0.8	-1.4	-0.5
Primary Biliary Cirrhosis	0.6	0.8	2.6	0.4	-1.6	-0.4	-0.6	-0.6	-1.1
Rheumatoid Arthritis	0.6	0.8	3.2	-1.8	-0.0	0.1	0.6	0.7	0.9
BMI	0.6	3.6	5.8	2.4	-2.1	-0.6	-1.9	-2.2	-1.7
Lung FVC	0.6	3.3	4.9	-2.0	2.1	1.1	1.4	1.8	2.2
Number of treatments/medications taken	0.6	1.1	4.0	2.0	0.6	1.3	0.4	0.1	0.6
Trunk fat percentage	0.6	2.2	6.6	2.6	-1.1	-0.6	-1.4	-1.5	-1.1
Qualifications: CSEs or equivalent	0.6	0.7	2.2	-0.1	-1.5	0.8	1.1	0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.4	-0.2	1.8	1.0	1.0	0.8	1.5
Forced vital capacity (FVC)	0.6	2.2	8.1	-2.8	1.2	-0.4	1.2	1.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.1	-1.2	1.4	0.5	0.9	1.4	1.2
Trunk fat-free mass	0.6	3.7	8.9	-1.8	-0.9	-3.0	-2.0	-2.1	-0.7
Hip circumference	0.6	2.4	5.0	0.2	-0.6	-2.1	-2.2	-2.1	-0.6
Lung cancer (father)	0.6	0.8	3.0	-0.5	1.7	-0.6	-0.2	0.3	0.9
Trunk predicted mass	0.6	3.6	8.8	-1.9	-0.9	-3.0	-2.0	-2.0	-0.7
Length of working week for main job	0.6	0.7	1.1	-0.4	-0.6	-1.1	-0.9	-0.8	-1.0
Loud music exposure frequency	0.6	0.6	2.1	-1.5	0.6	-0.1	0.4	0.5	0.8
Medication: Paracetamol	0.6	0.9	2.2	-0.2	1.4	0.7	0.5	0.8	1.5
Headache pain in last month	0.6	1.0	2.2	-0.4	1.5	0.2	0.4	1.1	1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.0	-1.3	1.1	0.6	0.5	1.4	1.3
Birth weight	0.6	1.2	2.0	0.1	-0.6	-1.4	-1.4	-1.4	-1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	-0.3	-1.0	-1.4	-0.4	-0.9	-1.4
Whole body fat mass	0.6	2.5	3.8	1.6	-1.2	-1.4	-1.9	-1.9	-1.2
Leg fat mass (right)	0.6	2.3	3.2	1.7	-1.3	-0.9	-1.8	-1.8	-1.3
Pulse rate, automated reading	0.6	1.9	3.6	1.1	-1.9	-0.6	-1.0	-1.8	-1.5
Whole body fat-free mass	0.6	3.7	8.8	-1.4	-1.0	-3.0	-2.1	-2.2	-0.9
Arm fat percentage (left)	0.6	2.3	4.6	2.1	-1.1	-0.7	-1.8	-1.7	-1.2
Loneliness, isolation	0.6	0.8	2.8	-1.7	-0.3	-0.9	-0.8	0.2	0.3
Friendships satisfaction	0.6	0.7	1.2	0.3	1.1	0.7	1.1	1.1	0.5
Medication for cholesterol	0.6	1.0	2.6	-1.6	-1.1	-1.1	-0.7	-0.5	-0.2
Number of self-reported non-cancer illnesses	0.6	1.1	2.8	0.5	1.5	0.7	0.1	0.7	1.7
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-0.2	-0.8	-1.0	-0.7	-1.1	-1.2
Ever taken oral contraceptive pill	0.6	0.7	1.4	-0.8	0.4	-1.1	-1.2	-0.7	0.1
Financial situation satisfaction	0.6	0.7	1.8	1.4	0.2	1.1	0.6	0.6	0.6
Number of operations (self-reported)	0.6	0.9	2.6	-0.8	0.7	0.6	0.5	1.1	1.6
Irritability	0.6	1.0	5.1	-2.3	0.1	-0.6	-0.2	0.3	0.3
Diastolic blood pressure, automated reading	0.6	1.8	3.2	1.8	-1.8	-0.1	-0.8	-1.2	-1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	1.4	-1.0	0.1	0.2	-1.1	-0.8
Bipolar Disorder (2018)	0.5	0.8	3.7	-1.9	-0.3	-0.8	-0.5	0.1	0.2
Neuroticism (Nagel 2018)	0.5	1.1	4.2	-2.1	-0.3	-1.3	-0.7	-0.4	-0.0
Crohns Disease (2017)	0.5	1.1	1.8	-1.4	0.7	0.7	1.0	1.0	1.2
Sensitivity / hurt feelings	0.5	0.8	3.2	-1.8	0.9	-0.4	0.3	0.7	0.4
Angina	0.5	0.6	1.2	1.0	0.7	1.1	0.3	0.5	0.8
Medication: Co-codamol	0.5	0.6	1.1	-0.1	-0.4	1.1	1.1	0.8	0.8
Hand grip strength (right)	0.5	1.4	4.7	-2.2	1.1	-0.7	-0.1	1.2	0.8
Fed-up feelings	0.5	1.0	3.3	-1.8	-1.3	-0.7	-0.4	-0.3	-0.3
High blood pressure (mother)	0.5	0.7	1.3	0.2	1.1	0.8	1.0	0.7	0.7
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-0.1	-0.1	-1.3	-1.1	-0.8	-0.2
Heart attack	0.5	0.7	2.3	1.5	-0.7	0.5	0.5	-0.8	-0.6
Arm fat percentage (right)	0.5	2.0	4.5	2.1	-1.0	-0.6	-1.8	-1.5	-1.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.9	0.0	0.8	0.7	0.3	0.9	1.7
Noisy workplace	0.5	0.6	1.5	1.1	-0.1	1.2	1.0	0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.3	-1.8	-0.4	-1.0	-0.8	0.2	-0.6
Glaucoma (self-reported)	0.5	0.5	1.6	0.3	1.3	0.5	0.6	0.6	0.8
Body fat percentage	0.5	2.1	6.6	2.6	-1.1	-0.3	-1.3	-1.3	-1.1
Number of full brothers	0.5	0.7	2.0	-1.4	0.4	-0.6	-0.5	0.3	1.1
Qualifications: College or University degree	0.5	1.6	4.4	-0.3	2.1	0.1	0.7	1.1	1.8
Angina (self-reported)	0.5	0.7	1.8	1.3	0.6	1.1	0.3	0.3	0.6
Medication: Omeprazole	0.5	0.6	1.3	-0.2	0.2	1.1	0.5	0.9	1.1
Arm predicted mass (right)	0.5	2.4	5.5	-1.3	-1.1	-2.3	-1.3	-1.9	-0.8
Alcohol intake frequency.	0.5	1.1	4.2	2.0	-0.1	-0.0	-0.4	-0.5	-1.3
Number of full sisters	0.5	0.6	1.9	-1.4	0.0	-0.0	-0.2	0.9	1.0
Had major operations	0.5	0.6	2.8	1.7	-0.4	0.2	-0.2	-0.7	-0.2
Knee pain experienced in last month	0.5	0.8	1.4	1.1	-1.2	0.2	-0.2	-0.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.1	0.2	1.0	0.3	-0.5	0.3	1.5
Ever had bowel cancer screening	0.5	0.6	1.1	0.3	-1.0	-0.6	-0.9	-1.0	-0.6
Diabetes diagnosed by doctor	0.5	0.9	3.5	1.9	0.6	0.9	0.6	0.0	0.2
Arm fat-free mass (left)	0.5	2.4	5.2	-1.0	-1.1	-2.3	-1.6	-1.8	-0.8
Average weekly beer plus cider intake	0.5	0.7	1.1	-0.3	-1.0	-1.0	-0.2	-1.1	-1.0
Fractured/broken bones in last 5 years	0.5	0.7	0.9	0.8	-1.0	-0.6	-0.9	-1.0	-0.7
Arm predicted mass (left)	0.5	2.5	5.5	-1.2	-1.2	-2.3	-1.6	-1.8	-0.7
Irritable Bowel Disease (IBD)	0.4	0.8	4.1	-2.0	0.2	-0.6	0.4	0.4	0.6
Ulcerative Colitis (UC)	0.4	0.8	2.4	-1.3	-0.2	-1.5	-0.5	-0.5	-0.4
Major Depression (MDD)	0.4	0.5	1.6	-1.3	-0.3	-1.0	-0.5	-0.3	-0.1
Breast Cancer	0.4	0.9	1.3	-0.7	0.9	0.7	1.0	1.0	1.2
Bipolar Disorder (2011)	0.4	0.4	1.4	-1.2	-0.6	-0.5	-0.1	-0.4	-0.3
Mean Putamen Volume	0.4	0.4	1.1	-0.5	0.5	-1.1	-0.5	-0.4	0.6
Height	0.4	6.8	24.5	-2.0	0.1	-5.0	-2.8	-2.1	-0.2
Neuroticism	0.4	0.9	2.0	-1.4	-0.6	-1.3	-1.0	-0.5	0.0
Hearing difficulty/problems: Yes	0.4	0.6	2.8	1.7	0.5	-0.2	-0.0	-0.7	-0.2
Townsend deprivation index at recruitment	0.4	0.5	2.3	0.3	1.5	-0.0	-0.4	0.5	0.6
Current tobacco smoking	0.4	0.7	1.3	-0.5	-0.4	-1.2	-1.1	-0.7	-0.6
Supplements: Glucosamine	0.4	0.5	1.3	-1.0	0.2	-1.1	-0.7	-0.3	0.2
Impedance of leg (left)	0.4	2.1	4.3	0.4	0.0	1.9	2.1	2.0	0.6
Waist circumference	0.4	1.5	3.8	0.2	-0.2	-1.6	-1.9	-1.5	-0.5
Had menopause	0.4	0.5	1.3	-1.1	-0.5	-0.8	-0.8	-0.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-1.0	1.1	-0.9	0.0	-0.0	0.3
Diabetes (self-reported)	0.4	0.6	2.9	1.7	0.4	0.5	0.5	-0.1	-0.2
Tense / ‘highly strung’	0.4	0.6	3.2	-1.8	-0.2	-0.4	-0.1	0.2	0.4
Leg fat percentage (right)	0.4	1.3	5.2	2.3	-0.7	0.4	-0.9	-0.7	-0.8
Arm fat-free mass (right)	0.4	2.3	5.3	-1.2	-1.1	-2.3	-1.4	-1.8	-0.8
Age at first live birth	0.4	0.7	1.1	-0.1	-0.8	-1.0	-0.7	-1.1	-1.0
Heart disease (mother)	0.4	0.5	1.0	-0.4	0.3	0.7	0.7	1.0	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.4	-0.3	1.1	1.1	0.3	-0.1
Age at last live birth	0.4	0.5	1.1	0.5	-0.9	-0.4	-0.2	-0.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	-0.1	0.9	0.7	0.9	0.8	0.3
Long-standing illness, disability or infirmity	0.4	0.7	1.4	-0.4	0.9	-1.2	-1.2	-0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	-1.1	-0.6	-0.6	-0.6	-0.1	-0.1
Hearing aid user	0.4	0.4	0.8	-0.5	0.9	-0.9	-0.9	-0.3	0.2
Medication: Paracetamol	0.4	0.6	1.1	1.0	0.8	0.9	0.4	0.4	0.6
Illnesses of father: High blood pressure	0.4	0.5	2.5	1.6	0.5	0.2	0.0	-0.2	-0.6
Age started oral contraceptive pill	0.4	0.5	2.1	-1.5	0.2	-0.6	-0.2	0.2	0.8
Cholesterol lowering medication	0.4	0.5	1.3	1.1	1.1	0.3	-0.2	0.3	0.7
Leg fat mass (left)	0.4	1.6	2.4	1.6	-1.2	-0.8	-1.4	-1.4	-1.0
Depression (Nagel 2018)	0.3	0.5	0.8	-0.8	-0.6	-0.9	-0.8	-0.7	-0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.8	0.7	-0.1	-0.0	0.5	0.8
Ovarian Cancer	0.3	0.4	1.0	-1.0	-0.9	0.2	0.5	0.4	-0.1
Prostate Cancer	0.3	0.4	0.8	-0.6	0.9	-0.4	-0.7	-0.2	0.7
Blood Eosinophil Count	0.3	2.0	9.6	3.1	0.9	1.0	0.7	-0.1	0.1
Blood Platelet Count	0.3	3.3	5.9	-0.8	2.1	1.2	1.8	2.1	2.4
Smoking Status	0.3	0.7	1.3	-0.6	-0.6	-1.0	-1.1	-0.9	-0.5
Relative age of first facial hair	0.3	0.7	1.6	-0.9	0.7	-1.0	-1.3	-0.3	0.3
Systolic blood pressure, automated reading	0.3	0.9	1.8	0.9	-0.9	1.4	1.2	0.5	-0.1
Pack years adult smoking proportion	0.3	0.5	1.2	-0.9	0.0	0.3	1.1	0.6	0.6
Body mass index (BMI)	0.3	1.1	2.5	1.2	-0.6	-0.6	-1.6	-1.4	-0.6
Allergy	0.3	0.6	1.7	-1.3	-1.1	-0.5	-0.3	0.3	-0.4
Medication: Simvastatin	0.3	0.4	1.0	0.9	-0.3	1.0	0.7	0.1	0.1
Neuroticism score	0.3	0.7	3.8	-1.9	-0.4	-0.5	-0.1	0.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.8	-1.3	0.3	-0.1	0.0	0.4	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.9	0.6	1.7	0.2	0.4	0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.5	0.4	0.7	0.7	0.6	0.7	0.6
Asthma	0.3	0.5	2.1	0.4	1.4	0.5	0.4	0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	0.9	-0.5	0.0	-0.3	-0.6	-0.6
Medication: Lansoprazole	0.3	0.4	1.1	0.5	0.2	-0.6	-1.0	-0.5	0.4
Gout (self-reported)	0.3	0.4	1.0	0.9	-0.3	-0.4	-0.2	-0.4	-1.0
Worry too long after embarrassment	0.3	0.5	1.0	-0.0	-0.4	-0.7	-1.0	-0.7	-0.9
Neck or shoulder pain in last month	0.3	0.4	1.1	0.1	0.9	0.6	0.1	0.5	1.0
Medication: Allopurinol	0.3	0.4	1.2	1.1	-0.1	-0.2	-0.5	-0.6	-0.6
Suffer from ‘nerves’	0.3	0.4	0.8	0.9	-0.5	0.7	0.5	-0.3	-0.8
Family relationship satisfaction	0.3	0.4	1.3	0.8	1.2	0.2	0.5	0.4	0.2
Smoking status: Previous	0.3	0.4	0.9	-0.3	0.1	-0.9	-0.7	-0.9	-0.4
Asthma (self-reported)	0.3	0.7	2.0	0.3	1.4	0.7	0.6	0.5	0.9
Osteoarthritis (self-reported)	0.3	0.4	0.9	0.3	0.6	0.8	0.3	0.7	0.9
Smoking status: Current	0.3	0.5	1.0	-0.3	-0.3	-1.0	-1.0	-0.6	-0.4
Wears glasses or contact lenses	0.3	0.3	1.6	1.3	-0.1	0.4	-0.0	0.0	-0.0
Leg fat percentage (left)	0.3	0.9	4.2	2.1	-0.6	0.7	-0.4	-0.3	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.5	1.1	1.2	-0.6	-1.1	-0.4	0.4
Lupus	0.2	0.3	0.9	0.9	0.6	0.0	0.6	0.1	0.3
Blood White Count	0.2	1.7	5.7	2.4	-1.0	-0.2	-0.7	-1.3	-1.0
Systolic Blood Pressure	0.2	0.9	1.7	0.8	-1.1	1.3	1.2	0.4	-0.5
Cardiovascular Disease	0.2	0.6	1.6	1.2	-1.3	0.4	0.1	-0.5	-0.7
Tanning	0.2	2.4	3.4	-0.3	-1.5	-1.7	-1.8	-1.8	-1.4
Average weekly spirits intake	0.2	0.3	0.7	0.1	-0.5	-0.2	-0.5	-0.8	-0.8
Diabetes (father)	0.2	0.3	0.5	0.7	0.6	0.3	0.3	0.3	0.7
Impedance of leg (right)	0.2	0.9	1.8	0.8	-0.3	1.4	1.2	1.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.0	-0.2	-0.7	-0.6	-0.8	-0.2
Age when periods started (menarche)	0.2	0.5	1.3	1.1	-1.1	0.6	0.1	-0.4	-0.4
Hearing difficulty/problems with background noise	0.2	0.2	0.6	0.7	0.2	0.3	0.8	-0.2	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.6	0.2	0.5	0.2	0.8	0.7
Worrier / anxious feelings	0.2	0.3	0.9	-1.0	0.4	-0.0	0.3	0.1	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.4	0.5	0.8	0.7	0.6	0.2
Depression (self-reported)	0.2	0.3	0.6	-0.8	0.3	-0.2	-0.6	0.2	0.6
Illnesses of mother	0.2	0.3	1.0	-0.6	-1.0	0.3	-0.1	0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.9	1.0	0.5	0.5	0.0	0.3	0.5
Comparative body size at age 10	0.2	0.7	2.0	-1.4	-1.2	-0.0	-0.7	-0.1	-0.0
Shortness of breath walking on level ground	0.2	0.3	0.9	-0.6	-0.1	-0.9	-0.3	-0.3	-0.3
Overall health rating	0.2	0.4	1.4	1.2	-0.5	0.1	-0.3	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.7	0.3	0.2	0.1	0.5	0.5
Illnesses of father: Heart disease	0.2	0.3	0.9	0.3	-0.1	0.8	0.9	0.4	0.4
Average weekly red wine intake	0.2	0.3	1.6	-0.0	1.3	-0.3	-0.5	-0.2	0.3
Mineral and other dietary supplements	0.2	0.3	0.9	-0.1	0.2	0.7	0.9	0.6	-0.2
Miserableness	0.2	0.4	1.2	-1.1	-0.7	-0.6	-0.2	-0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	-0.4	0.5	0.1	-0.2	-0.5
Pain experienced in last month	0.2	0.4	0.8	0.9	-0.4	-0.0	0.1	-0.7	-0.8
Pack years of smoking	0.2	0.3	1.1	-0.4	-0.1	0.4	1.0	0.4	0.4
Worry (Nagel 2018)	0.1	0.3	1.3	-1.1	0.4	-0.3	0.3	0.1	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	-0.4	-0.8	-0.0	-0.2	-0.3	-0.1
LDL Cholesterol	0.1	0.1	0.3	0.0	0.3	0.5	0.3	0.1	0.4
Ulcerative Colitis	0.1	0.2	0.7	-0.9	0.1	-0.3	-0.2	0.2	0.2
Heel T-Score	0.1	1.1	4.4	2.1	-0.4	1.2	0.5	0.2	-0.8
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.7	0.4	0.1	-0.2	0.2	-0.9
Hair Pigment	0.1	1.6	2.9	-1.7	0.8	0.7	0.9	1.5	1.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.0	-0.2	-0.3	-0.5	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.6	-0.1	0.7	-0.4	-0.1	0.1	0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.2	0.6	-0.4	-0.4	-0.1	0.5
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.5	0.2	0.4	-0.0	0.4	0.7
Nervous feelings	0.1	0.3	1.4	-1.2	0.0	-0.3	0.2	0.1	0.0
Time employed in main current job	0.1	0.1	0.3	0.6	0.2	0.5	0.2	0.2	0.1
Father’s age at death	0.1	0.1	0.4	0.6	0.1	-0.0	-0.6	0.2	-0.1
Impedance of arm (left)	0.1	0.5	1.6	1.3	-0.5	-0.2	-0.2	-0.1	-0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.2	-0.6	0.0	-0.2	0.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	-0.2	-0.3	-0.4	-0.8	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.0	0.7	0.3	-0.1	0.4	0.5
Comparative height size at age 10	0.1	0.3	1.1	-0.6	-0.2	-1.1	0.4	-0.4	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.3	0.5	-0.5	-0.6	0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.2	-0.2	-0.0	-0.5	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.0	0.5	0.3	-0.3	0.0	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.3	0.6	-0.2	-0.0	-0.1	-0.0
Heart disease (siblings)	0.1	0.1	0.2	0.5	-0.4	-0.1	-0.4	-0.3	-0.3
Impedance of whole body	0.1	0.6	1.4	1.2	-0.2	0.8	0.9	0.9	-0.2
Impedance of arm (right)	0.0	0.2	0.8	0.9	-0.1	0.2	0.1	0.6	-0.2
Health satisfaction	0.0	0.0	0.1	0.2	0.1	-0.2	-0.4	-0.0	0.3
Back pain experienced in last month	0.0	0.0	0.1	0.0	0.2	0.0	0.2	0.2	-0.1

Hub : Genes

GPATCH2L

Models

Trait associations