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chr19:34,751,306-36,530,913

Best TWAS P=3.07e-11 · Best GWAS P=1.2e-13 conditioned to 0.111

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	CD22	0.35	0.17	enet	17	0.25	2.5e-09	4.9	5.8	8.6e-09	0.48	0.88	0.07	FALSE
2	GTEx	Artery Coronary	LSR	0.23	0.21	enet	6	0.22	5.6e-08	-5.6	-5.2	1.5e-07	-0.63	0.19	0.71	FALSE
3	GTEx	Artery Tibial	CD22	0.17	0.15	lasso	4	0.14	9.5e-11	5.3	5.8	6.8e-09	0.56	0.99	0.00	FALSE
4	GTEx	Colon Sigmoid	CD22	0.23	0.11	lasso	2	0.11	1.3e-04	5.3	5.6	2.4e-08	0.50	0.36	0.17	FALSE
5	GTEx	Heart Atrial Appendage	CD22	0.25	0.29	lasso	2	0.27	1.4e-12	5.3	5.3	8.9e-08	0.50	1.00	0.00	FALSE
6	GTEx	Heart Atrial Appendage	ZNF792	0.19	-0.01	enet	16	0.01	1.6e-01	2.9	-5.4	7.1e-08	-0.39	0.06	0.17	FALSE
7	GTEx	Heart Left Ventricle	CD22	0.18	0.16	lasso	4	0.14	1.1e-07	5.3	5.4	5.3e-08	0.49	0.95	0.02	FALSE
8	GTEx	Liver	CD22	0.39	0.14	enet	6	0.08	2.5e-03	5.3	5.6	2.1e-08	0.55	0.14	0.52	FALSE
9	GTEx	Lung	CD22	0.24	0.12	enet	55	0.15	2.3e-11	5.3	5.7	1.6e-08	0.43	1.00	0.00	TRUE
10	GTEx	Nerve Tibial	CD22	0.18	0.13	enet	24	0.12	1.1e-08	6.2	5.9	3.2e-09	0.55	0.79	0.21	FALSE
11	GTEx	Pituitary	CD22	0.47	0.42	lasso	3	0.46	5.6e-13	5.3	5.4	5.4e-08	0.49	0.95	0.03	FALSE
12	GTEx	Thyroid	CD22	0.31	0.27	lasso	4	0.30	1.5e-23	5.3	5.3	9.7e-08	0.51	1.00	0.00	FALSE
13	GTEx	Uterus	CD22	0.57	0.41	lasso	5	0.23	1.7e-05	5.3	5.5	4.5e-08	0.50	0.36	0.15	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAG	0.04	0.06	lasso	2	0.05	1.3e-10	5.3	5.3	8.7e-08	0.50	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MAG	0.06	0.07	lasso	1	0.07	6.3e-08	5.3	5.3	9.9e-08	0.50	0.96	0.03	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CD22	0.14	0.14	lasso	2	0.13	2.8e-14	5.3	5.3	8.7e-08	0.50	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAG	0.48	0.30	enet	32	0.36	3.0e-42	5.3	5.7	1.1e-08	0.56	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CD22	0.09	0.04	lasso	1	0.01	7.8e-02	5.3	5.3	9.9e-08	0.50	0.02	0.30	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MAG	0.23	0.25	lasso	2	0.23	1.8e-13	5.3	5.4	8.2e-08	0.50	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	LSR	0.06	0.04	lasso	3	0.03	2.6e-04	6.5	-6.6	3.1e-11	-0.83	0.01	0.98	TRUE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	MAG	0.43	0.36	lasso	7	0.36	6.3e-44	5.3	5.5	5.2e-08	0.49	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MAG	0.24	0.25	lasso	3	0.25	2.9e-28	5.3	5.4	7.9e-08	0.50	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MAG	0.32	0.23	lasso	2	0.24	2.0e-10	5.3	5.3	1.2e-07	0.49	0.97	0.03	FALSE
24	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CD22	0.58	0.50	lasso	2	0.51	6.4e-23	5.3	5.3	8.6e-08	0.50	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MAG	0.56	0.48	lasso	4	0.46	2.1e-20	5.3	5.3	8.7e-08	0.50	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	CD22	0.41	0.27	lasso	4	0.27	1.9e-28	5.3	5.8	7.9e-09	0.46	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAG	0.67	0.48	lasso	6	0.47	1.3e-55	5.3	5.4	7.0e-08	0.50	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Soft Tissue Sarcoma	MAG	0.29	0.22	lasso	3	0.23	8.6e-14	5.3	5.4	5.8e-08	0.50	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MAG	0.27	0.22	lasso	2	0.13	2.8e-04	5.3	5.3	1.3e-07	0.48	0.15	0.09	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	MAG	0.19	0.24	lasso	2	0.22	3.4e-16	5.3	5.3	8.9e-08	0.50	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	CD22	0.46	0.42	lasso	4	0.44	2.3e-46	5.3	5.5	4.7e-08	0.52	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	FFAR1	0.38	0.28	lasso	5	0.28	7.1e-27	5.3	5.5	3.8e-08	0.50	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	MAG	0.63	0.50	lasso	6	0.52	6.6e-58	5.3	5.7	1.4e-08	0.54	1.00	0.00	FALSE