Best TWAS P=1.88e-13 · Best GWAS P=3.09e-30 conditioned to 2.57e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | ROSMAP | Brain Pre-frontal Cortex | SHKBP1 | 0.08 | 0.02 | enet | 12 | 0.04 | 8.2e-06 | 3.2 | -7.4 | 1.9e-13 | 0.30 | 0.72 | 0.01 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | AXL | 0.14 | 0.07 | lasso | 1 | 0.05 | 3.6e-05 | -6.4 | -6.4 | 1.6e-10 | -0.01 | 0.57 | 0.02 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYP2A7 | 0.07 | 0.06 | lasso | 2 | 0.06 | 8.1e-07 | -6.5 | -6.2 | 6.6e-10 | 0.49 | 0.25 | 0.73 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MIA | 0.08 | 0.00 | blup | 60 | 0.01 | 4.0e-02 | 5.0 | 6.1 | 1.4e-09 | -0.30 | 0.01 | 0.45 | TRUE |
| 4 | NTR | Blood | SHKBP1 | 0.05 | 0.04 | enet | 18 | 0.04 | 3.1e-13 | 4.8 | 5.2 | 1.7e-07 | -0.09 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LTBP4 | 0.01 | 0.00 | blup | 54 | 0.01 | 2.0e-02 | 6.0 | -6.3 | 2.7e-10 | 0.13 | 0.03 | 0.22 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | LTBP4 | 0.09 | 0.05 | lasso | 9 | 0.04 | 3.9e-06 | 6.2 | -6.3 | 3.5e-10 | 0.11 | 0.99 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AXL | 0.03 | 0.04 | lasso | 2 | 0.03 | 2.3e-04 | -6.0 | -6.2 | 7.6e-10 | 0.00 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Tibial | AXL | 0.16 | 0.08 | lasso | 6 | 0.06 | 1.7e-05 | -6.0 | -5.6 | 1.9e-08 | 0.00 | 0.96 | 0.00 | FALSE |