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chr19:32,372,820-34,691,449

Best TWAS P=5.82e-52 · Best GWAS P=9.54e-68 conditioned to 4.87e-33

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PEPD	0.32	0.27	enet	22	0.38	1.2e-49	-8.94	-7.5	5.9e-14	-0.01	1.00	0.00	FALSE
2	GTEx	Artery Tibial	PEPD	0.11	0.02	lasso	3	0.02	5.3e-03	-8.96	-6.7	3.0e-11	0.08	0.34	0.02	TRUE
3	GTEx	Artery Tibial	CEBPG	0.14	0.04	lasso	3	0.02	5.9e-03	-5.50	-7.7	1.5e-14	0.03	0.66	0.01	FALSE
4	GTEx	Brain Cerebellar Hemisphere	CTD-2085J24.4	0.31	0.02	lasso	9	0.01	1.8e-01	3.94	6.7	2.1e-11	0.17	0.07	0.06	FALSE
5	GTEx	Brain Frontal Cortex BA9	PDCD5	0.22	0.01	enet	26	0.09	2.2e-03	3.80	6.8	1.2e-11	0.11	0.12	0.31	FALSE
6	GTEx	Brain Frontal Cortex BA9	CTD-2538C1.2	0.45	0.02	enet	40	0.18	1.3e-05	6.15	6.4	1.5e-10	0.14	0.10	0.57	FALSE
7	GTEx	Brain Hippocampus	PDCD5	0.36	0.04	enet	16	0.14	3.9e-04	5.81	7.0	3.7e-12	0.13	0.12	0.17	FALSE
8	GTEx	Brain Hippocampus	RHPN2	0.22	-0.01	enet	9	0.00	3.3e-01	7.60	6.4	1.2e-10	0.14	0.07	0.06	FALSE
9	GTEx	Colon Transverse	CEP89	0.19	0.01	enet	20	0.10	1.8e-05	3.73	-6.0	1.9e-09	-0.10	0.11	0.04	FALSE
10	GTEx	Colon Transverse	CTD-2538C1.2	0.16	0.02	enet	26	0.07	3.6e-04	5.88	6.4	1.5e-10	0.08	0.08	0.81	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	C19orf40	0.39	0.01	enet	26	0.06	3.7e-03	-2.89	7.9	2.0e-15	0.26	0.07	0.19	FALSE
12	GTEx	Heart Atrial Appendage	CTD-2538C1.2	0.31	0.37	lasso	2	0.36	8.1e-17	5.78	5.9	4.1e-09	0.11	1.00	0.00	FALSE
13	GTEx	Heart Left Ventricle	CTD-2538C1.2	0.21	0.25	enet	9	0.21	2.5e-11	5.78	5.9	4.5e-09	0.11	0.98	0.02	FALSE
14	GTEx	Prostate	CEP89	0.36	0.03	lasso	6	0.02	8.6e-02	-6.49	-5.2	1.7e-07	0.06	0.07	0.05	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	CTD-2085J24.4	0.16	0.11	enet	9	0.10	4.4e-06	3.71	5.2	1.5e-07	0.11	0.89	0.01	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CEBPG	0.16	0.08	enet	11	0.14	6.1e-12	4.59	-8.1	4.8e-16	0.02	1.00	0.00	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CTD-2085J24.4	0.17	0.06	enet	31	0.06	5.0e-06	3.94	5.2	1.7e-07	0.06	0.91	0.00	FALSE
18	GTEx	Stomach	CTD-2538C1.2	0.09	0.04	lasso	3	0.03	1.4e-02	5.92	6.0	1.7e-09	0.10	0.11	0.69	FALSE
19	GTEx	Thyroid	CTD-2085J24.4	0.09	0.09	lasso	2	0.07	3.1e-06	7.60	7.1	1.1e-12	0.14	0.87	0.00	FALSE
20	METSIM	Adipose	PDCD5	0.06	0.02	bslmm	393	0.01	9.9e-03	0.19	5.9	3.7e-09	0.12	0.48	0.27	FALSE
21	METSIM	Adipose	SLC7A9	0.09	0.05	enet	15	0.08	9.5e-12	-7.06	-5.5	4.4e-08	-0.07	1.00	0.00	FALSE
22	NTR	Blood	ANKRD27	0.07	0.08	bslmm	425	0.08	2.0e-25	-5.11	-6.2	7.7e-10	-0.06	1.00	0.00	TRUE
23	YFS	Blood	CEBPA	0.11	0.02	bslmm	447	0.04	1.9e-14	5.89	-7.1	1.5e-12	0.06	0.99	0.00	FALSE
24	YFS	Blood	CEBPG	0.08	0.05	bslmm	455	0.05	5.0e-17	4.35	-6.5	1.1e-10	0.01	1.00	0.00	TRUE
25	YFS	Blood	PEPD	0.07	0.04	bslmm	488	0.05	5.6e-16	-8.92	-5.7	1.5e-08	0.02	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SLC7A9	0.09	0.03	blup	59	0.05	4.0e-05	-6.83	-6.3	2.8e-10	-0.07	0.22	0.50	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC7A9	0.13	0.13	blup	59	0.17	9.0e-33	3.94	-5.9	4.2e-09	-0.08	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CEBPA	0.14	0.00	blup	39	0.07	1.6e-04	5.15	-15.2	5.8e-52	-0.23	0.01	0.21	TRUE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SLC7A9	0.12	0.11	enet	7	0.13	8.1e-07	-6.83	-8.1	6.8e-16	-0.12	0.07	0.88	TRUE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	SLC7A9	0.36	0.13	blup	59	0.18	3.0e-06	7.90	-8.0	8.8e-16	-0.13	0.00	0.98	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC7A9	0.05	0.01	blup	59	0.04	1.8e-05	0.80	-6.7	2.8e-11	-0.06	0.18	0.54	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	PEPD	0.05	0.03	blup	113	0.05	7.1e-07	-3.10	-5.6	2.1e-08	-0.04	0.91	0.01	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC7A9	0.20	0.07	enet	12	0.21	5.6e-23	3.71	-7.2	4.5e-13	-0.10	0.96	0.04	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	TDRD12	0.03	0.01	blup	58	0.01	1.1e-02	6.59	6.1	1.2e-09	0.12	0.22	0.22	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC7A9	0.07	0.04	lasso	4	0.07	1.8e-08	7.90	-7.2	8.1e-13	-0.11	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC7A9	0.11	0.06	blup	59	0.09	9.0e-11	-6.24	-6.7	2.4e-11	-0.09	0.06	0.94	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC7A9	0.08	0.03	enet	11	0.03	4.8e-03	-7.06	-7.6	2.1e-14	-0.09	0.09	0.39	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	PEPD	0.08	0.04	lasso	8	0.03	2.8e-04	-7.38	-8.2	3.1e-16	0.00	0.26	0.13	TRUE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC7A9	0.21	0.10	enet	25	0.20	1.1e-20	3.71	-5.7	1.2e-08	-0.08	0.95	0.05	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	SLC7A9	0.14	0.00	blup	59	0.08	1.3e-05	-6.65	-7.5	6.5e-14	-0.09	0.06	0.75	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	SLC7A9	0.10	0.08	blup	59	0.08	3.9e-08	-6.24	-5.8	6.3e-09	-0.06	0.76	0.22	FALSE