TWAS hub - CD22

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.3493	0.0915	3.8e-04	0.170	NA	0.246	NA	0.229	1.0e-06	NA	2.5e-09	NA	9.7e-09
2	GTEx	Artery Tibial	0.1664	0.0436	3.3e-05	0.152	NA	0.129	NA	0.135	5.3e-12	NA	2.8e-10	NA	9.5e-11
3	GTEx	Colon Sigmoid	0.2350	0.0760	5.0e-03	0.113	NA	0.080	NA	0.108	8.6e-05	NA	9.1e-04	NA	1.3e-04
4	GTEx	Heart Atrial Appendage	0.2520	0.0670	1.8e-04	0.293	NA	0.271	NA	0.271	1.3e-13	NA	1.4e-12	NA	1.4e-12
5	GTEx	Heart Left Ventricle	0.1815	0.0589	1.8e-03	0.159	NA	0.130	NA	0.136	7.8e-09	NA	2.0e-07	NA	1.1e-07
6	GTEx	Liver	0.3890	0.1050	1.7e-04	0.135	NA	0.083	NA	0.056	1.4e-04	NA	2.5e-03	NA	1.1e-02
7	GTEx	Lung	0.2407	0.0491	5.1e-08	0.122	NA	0.147	NA	0.143	1.4e-09	NA	2.3e-11	NA	4.7e-11
8	GTEx	Nerve Tibial	0.1831	0.0492	4.2e-05	0.128	NA	0.118	NA	0.115	2.6e-09	NA	1.1e-08	NA	1.7e-08
9	GTEx	Pancreas	0.2710	0.0810	1.3e-03	0.219	NA	0.201	NA	0.165	1.2e-09	NA	6.3e-09	NA	1.9e-07
10	GTEx	Pituitary	0.4710	0.0990	1.3e-04	0.418	NA	0.353	NA	0.457	1.0e-11	NA	9.8e-10	NA	5.6e-13
11	GTEx	Thyroid	0.3090	0.0490	4.5e-12	0.267	NA	0.283	NA	0.303	1.5e-20	NA	6.7e-22	NA	1.5e-23
12	GTEx	Uterus	0.5720	0.1520	1.3e-03	0.409	NA	0.145	NA	0.231	2.0e-09	NA	7.3e-04	NA	1.7e-05
13	NTR	Blood	0.0958	0.0211	4.8e-08	0.050	0.031	0.048	0.046	0.049	9.3e-16	1.8e-10	2.9e-15	1.4e-14	2.0e-15
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.1386	0.0416	5.0e-10	0.137	0.104	0.115	NA	0.129	3.7e-15	8.6e-12	7.5e-13	NA	2.8e-14
15	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0950	0.0490	8.3e-03	0.043	0.006	0.000	NA	0.010	1.7e-03	1.4e-01	3.4e-01	NA	7.8e-02
16	TCGA	Pheochromocytoma and Paraganglioma	0.5820	0.0740	4.4e-16	0.502	0.382	0.502	NA	0.506	1.0e-22	3.0e-16	9.9e-23	NA	6.4e-23
17	TCGA	Prostate Adenocarcinoma	0.4078	0.0727	0.0e+00	0.270	0.245	0.260	NA	0.272	3.1e-28	2.0e-25	4.2e-27	NA	1.9e-28
18	TCGA	Skin Cutaneous Melanoma	0.2080	0.0920	8.0e-03	0.051	0.038	0.082	NA	0.004	1.7e-02	3.5e-02	3.3e-03	NA	2.5e-01
19	TCGA	Thyroid Carcinoma	0.4630	0.0620	0.0e+00	0.424	0.374	0.432	NA	0.437	1.1e-44	3.3e-38	1.0e-45	NA	2.3e-46

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Osteoporosis (self-reported)	8.9	11.0	19.4	4.4	3.7	3.6	3.5	3.2	3.5	2.9	1.1	1.7	4.0	3.9	3.3	-0.4	3.8	3.4	3.8	3.2	2.9	3.8
Medication: Atenolol	5.7	7.1	11.0	-2.5	-2.9	-3.3	-3.0	-3.0	-2.3	-2.4	-0.1	-2.2	-3.0	-2.9	-3.0	2.0	-2.9	-3.0	-2.9	-2.8	-2.0	-2.9
Age started oral contraceptive pill	4.9	6.1	8.5	2.5	2.7	2.7	2.7	2.7	2.5	2.6	-0.0	2.9	2.6	2.6	2.8	0.0	2.6	2.7	2.6	2.9	1.3	2.6
Angina (self-reported)	4.3	5.7	8.6	-2.4	-2.6	-2.9	-2.7	-2.6	-2.5	-2.4	-0.0	-1.8	-2.5	-2.6	-2.6	0.3	-2.6	-2.7	-2.6	-2.5	-1.9	-2.6
Ever taken oral contraceptive pill	4.3	4.8	7.8	2.4	2.3	2.2	2.2	2.1	2.4	2.6	2.8	1.1	2.1	2.1	2.1	-2.0	2.2	2.2	2.2	1.8	2.3	2.2
Commuting to job workplace: Car/motor vehicle	4.1	4.7	6.5	-2.1	-2.3	-2.0	-2.3	-2.3	-2.6	-2.5	-0.9	-1.7	-2.3	-2.4	-2.3	-1.0	-2.4	-2.2	-2.4	-2.2	-1.8	-2.4
Chronic bronchitis/emphysema (father)	4.0	4.6	6.7	-2.2	-2.6	-2.4	-2.5	-2.3	-2.2	-2.5	-0.4	-0.9	-2.3	-2.5	-2.5	0.0	-2.3	-2.5	-2.3	-2.5	-0.8	-2.4
Diabetes (mother)	3.9	4.9	8.3	-2.3	-2.4	-2.3	-2.4	-2.4	-2.9	-1.9	0.3	-1.6	-2.6	-2.7	-2.4	0.3	-2.6	-2.3	-2.6	-2.3	-0.3	-2.6
Angina	3.8	5.0	7.6	-2.4	-2.4	-2.8	-2.5	-2.5	-2.3	-2.2	-0.0	-1.7	-2.4	-2.4	-2.4	0.5	-2.4	-2.5	-2.4	-2.2	-1.9	-2.4
Pain all over the body in last month	3.3	3.5	8.4	1.5	1.8	1.9	1.8	1.6	1.9	2.0	1.6	1.9	1.9	1.8	1.8	-2.9	1.9	1.8	1.9	1.8	1.4	1.9
Medication: Ramipril	3.3	4.3	6.2	-1.7	-2.3	-1.9	-2.3	-1.9	-2.4	-2.0	-0.4	-2.2	-2.1	-2.2	-2.5	1.3	-2.3	-2.3	-2.3	-2.5	-1.5	-2.3
Age at last live birth	3.3	4.8	7.0	2.4	2.3	2.4	2.5	2.6	2.4	1.0	-1.1	1.4	2.3	2.5	2.4	-0.2	2.5	2.5	2.5	2.0	2.2	2.5
Average weekly red wine intake	3.3	4.9	7.4	-2.5	-2.4	-2.1	-2.4	-2.3	-2.2	-2.3	-1.0	-1.7	-2.7	-2.6	-2.6	-0.5	-2.7	-2.3	-2.6	-2.0	-0.2	-2.6
Heart attack/myocardial infarction (self-reported)	3.0	3.9	6.0	-1.9	-2.2	-2.1	-2.2	-1.9	-2.1	-2.5	0.5	-1.2	-2.1	-2.2	-2.4	0.7	-2.2	-2.2	-2.2	-1.8	-1.5	-2.2
Blood Red Count	2.9	28.0	35.0	5.8	5.8	5.6	5.3	5.4	5.6	5.7	5.9	4.4	5.4	5.3	5.5	-3.1	5.3	5.3	5.3	5.8	3.4	5.5
Heart attack	2.9	3.7	5.4	-1.8	-2.1	-2.1	-2.2	-1.8	-2.0	-2.3	0.4	-1.3	-2.1	-2.1	-2.3	0.8	-2.2	-2.2	-2.2	-1.7	-1.5	-2.1
Mouth/teeth dental problems: Dentures	2.9	4.8	6.3	2.4	2.3	2.3	2.3	2.5	2.1	1.5	1.0	2.1	2.5	2.5	2.3	-1.8	2.4	2.3	2.4	2.2	1.9	2.4
Breastfed as a baby	2.8	3.5	4.7	-1.5	-2.1	-2.1	-2.1	-2.1	-2.0	-1.5	1.0	-1.8	-2.0	-2.1	-2.2	1.1	-2.0	-2.2	-2.0	-1.7	-1.2	-2.0
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	8.6	-1.9	-2.1	-1.7	-2.0	-1.8	-2.2	-2.7	0.4	-2.9	-2.4	-2.4	-2.1	-0.4	-2.3	-1.9	-2.2	-2.4	-0.4	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	4.0	1.5	1.8	1.7	1.7	1.8	2.0	1.6	0.9	1.5	1.9	1.9	1.7	0.4	2.0	1.7	2.0	1.6	1.3	1.9
Guilty feelings	2.4	3.7	6.3	-2.1	-2.0	-1.9	-1.9	-1.6	-2.5	-1.9	-2.5	-1.3	-1.8	-1.9	-2.0	0.2	-1.9	-1.9	-1.9	-1.9	-2.0	-1.9
Multivitamins +/- minerals	2.3	2.9	9.1	-1.9	-1.6	-1.5	-1.5	-1.4	-1.7	-3.0	-1.5	-1.8	-1.7	-1.7	-1.5	1.3	-1.6	-1.5	-1.6	-1.7	-1.3	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	7.3	-2.6	-2.1	-1.8	-1.8	-1.8	-2.5	-2.7	-0.9	-1.9	-2.2	-2.2	-1.9	0.2	-2.0	-1.8	-2.0	-1.9	-1.0	-2.0
Worry too long after embarrassment	2.3	3.9	9.2	-2.0	-2.1	-1.8	-2.0	-1.6	-2.3	-2.0	-3.0	-1.2	-2.1	-2.1	-2.0	0.4	-2.0	-1.9	-2.0	-2.1	-1.5	-2.1
Long-standing illness, disability or infirmity	2.3	3.5	5.4	-2.3	-1.9	-1.9	-2.0	-1.7	-2.1	-1.8	-0.1	-1.7	-2.0	-2.0	-1.7	1.2	-1.9	-2.0	-1.9	-2.2	-2.0	-2.0
Emphysema/chronic bronchitis	2.2	2.5	4.5	2.1	1.6	1.2	1.6	1.4	1.6	1.4	0.9	2.1	2.1	1.9	1.3	-0.5	1.8	1.5	1.8	1.8	-0.6	1.8
Number of live births	2.1	2.9	6.2	1.5	1.7	1.9	1.9	1.9	1.5	1.4	0.0	2.5	1.8	1.7	1.8	0.3	1.9	1.9	1.9	2.1	0.8	1.8
Risk taking	2.1	3.1	5.6	-2.3	-1.6	-1.6	-1.7	-1.5	-1.9	-1.4	0.9	-1.7	-2.4	-2.2	-1.6	0.9	-2.2	-1.6	-2.1	-1.5	-1.7	-2.0
Vascular/heart problems diagnosed by doctor	2.1	5.8	8.9	2.1	2.7	2.5	2.8	2.6	2.6	2.7	0.2	1.0	2.5	2.6	3.0	-0.8	2.6	2.8	2.6	2.6	2.2	2.6
Medication: Blood pressure	2.0	3.6	4.8	-1.9	-2.2	-2.1	-2.1	-1.9	-1.9	-1.9	-1.3	-1.4	-2.1	-2.0	-2.2	0.8	-2.0	-2.1	-2.0	-1.9	-1.1	-2.0
Alcohol drinker status: Previous	2.0	2.3	6.4	-1.9	-1.4	-1.6	-1.4	-1.4	-1.7	-0.5	1.5	-2.5	-1.5	-1.6	-1.5	-1.0	-1.4	-1.4	-1.4	-0.8	-1.5	-1.5
Rheumatoid Arthritis	1.9	2.7	3.9	1.2	1.9	1.6	1.8	1.9	1.8	1.5	1.6	1.0	1.7	1.8	2.0	0.7	1.8	1.8	1.8	1.4	1.2	1.8
Ever had hysterectomy (womb removed)	1.9	2.2	8.6	-1.3	-1.3	-1.2	-1.3	-0.9	-1.5	-2.9	-0.7	0.0	-1.5	-1.5	-1.4	1.5	-1.4	-1.3	-1.4	-0.9	-2.2	-1.4
Noisy workplace	1.9	2.4	9.1	1.8	1.1	1.0	1.1	1.2	1.1	1.6	0.4	3.0	1.3	1.2	1.1	-3.0	1.2	1.1	1.2	1.6	1.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	4.2	-2.1	-1.5	-1.6	-1.6	-1.3	-1.4	-1.8	0.1	-1.4	-1.5	-1.6	-1.4	-0.4	-1.5	-1.6	-1.5	-1.6	-0.9	-1.6
Comparative body size at age 10	1.9	5.2	8.4	-1.5	-2.6	-2.4	-2.7	-2.4	-2.4	-2.4	0.5	-1.6	-2.4	-2.5	-2.7	0.7	-2.5	-2.7	-2.5	-2.9	-1.1	-2.5
Miserableness	1.9	3.2	4.6	-1.5	-1.9	-2.0	-1.9	-1.8	-2.1	-1.9	-0.8	-1.0	-1.9	-1.8	-2.1	1.9	-1.8	-1.9	-1.8	-2.0	-1.8	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.8	-1.3	-1.5	-1.2	-1.4	-1.3	-1.6	-0.6	-0.3	-0.6	-1.6	-1.6	-1.3	2.2	-1.5	-1.4	-1.5	-1.2	-2.2	-1.5
Hypothyroidism (self reported)	1.7	3.9	5.6	1.7	2.2	1.2	2.1	2.1	1.9	1.3	2.4	1.3	2.2	2.2	2.1	-0.5	2.4	2.1	2.4	1.9	2.0	2.3
Vitamin and mineral supplements	1.7	2.3	7.7	1.6	1.4	1.4	1.4	1.4	1.5	2.8	1.6	1.4	1.5	1.4	1.3	-1.1	1.5	1.4	1.4	1.4	1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.5	-0.9	-1.3	-1.3	-1.4	-1.3	-1.7	-1.6	0.7	-1.4	-1.8	-1.7	-1.6	2.1	-1.6	-1.3	-1.5	-1.8	-1.9	-1.5
Ulcerative Colitis (UC)	1.6	3.1	9.4	1.7	1.7	1.2	1.4	1.2	2.1	2.7	3.1	0.3	1.9	1.7	1.4	-2.0	1.6	1.3	1.5	1.3	1.8	1.6
Hypertension (Self-reported)	1.6	4.4	6.9	-1.8	-2.3	-2.2	-2.4	-2.2	-2.5	-2.5	-0.4	-0.5	-2.1	-2.2	-2.6	0.8	-2.2	-2.4	-2.2	-2.2	-2.0	-2.2
Irritability	1.6	2.7	6.0	-1.2	-1.8	-1.7	-1.8	-1.5	-1.4	-1.9	-2.5	-1.4	-1.7	-1.6	-1.8	-0.6	-1.7	-1.8	-1.7	-1.9	0.1	-1.7
Blood White Count	1.5	11.3	16.0	2.5	3.9	3.3	3.6	3.5	3.8	2.7	3.9	3.8	3.2	3.3	3.7	-1.9	3.4	3.7	3.4	4.0	2.0	3.5
Pack years of smoking	1.5	2.3	4.0	1.8	1.6	1.7	1.6	1.7	1.2	1.0	0.5	2.0	1.8	1.7	1.5	-0.2	1.7	1.6	1.7	1.6	0.2	1.7
Pack years adult smoking proportion	1.4	2.1	4.4	1.6	1.6	1.6	1.5	1.6	1.2	0.8	1.1	2.1	1.6	1.6	1.3	-0.4	1.6	1.5	1.6	1.4	0.4	1.6
High blood pressure	1.4	3.9	6.3	-1.6	-2.2	-2.1	-2.3	-2.1	-2.3	-2.2	-0.5	-0.5	-2.1	-2.1	-2.5	0.7	-2.1	-2.3	-2.1	-2.2	-1.8	-2.1
Trunk fat-free mass	1.4	8.2	10.4	-2.4	-3.0	-2.9	-3.1	-2.7	-3.2	-2.8	0.9	-3.2	-3.1	-3.1	-3.2	2.3	-3.2	-3.0	-3.2	-3.1	-1.3	-3.1
Trunk predicted mass	1.4	7.8	9.9	-2.4	-2.9	-2.8	-3.0	-2.7	-3.1	-2.7	1.0	-3.1	-3.1	-3.1	-3.1	2.3	-3.1	-3.0	-3.1	-3.1	-1.2	-3.1
Medication: Seretide 50 evohaler	1.4	1.7	2.3	-1.4	-1.4	-1.5	-1.5	-1.1	-1.1	-0.8	1.1	-0.9	-1.5	-1.5	-1.3	-0.8	-1.5	-1.5	-1.5	-1.1	-0.7	-1.5
Pulse rate, automated reading	1.4	4.7	7.8	1.9	2.3	2.1	2.2	2.4	2.2	1.8	-0.3	2.5	2.2	2.2	2.3	-2.8	2.2	2.3	2.2	2.5	1.2	2.2
Hearing difficulty/problems with background noise	1.3	2.1	6.5	-1.6	-1.3	-1.0	-1.1	-1.0	-1.8	-1.9	-1.5	-2.0	-1.5	-1.5	-1.0	1.1	-1.2	-1.0	-1.2	-1.2	-2.6	-1.3
Pulse rate	1.3	2.2	8.5	0.8	1.4	1.5	1.5	1.8	1.5	0.9	-0.0	1.3	1.3	1.3	1.6	-2.9	1.3	1.6	1.4	2.1	0.5	1.3
Neck or shoulder pain in last month	1.3	1.8	3.6	-1.7	-1.2	-1.5	-1.3	-1.0	-1.2	-1.4	1.8	-1.0	-1.4	-1.4	-1.2	0.9	-1.3	-1.3	-1.3	-1.1	-1.9	-1.3
Heart disease (mother)	1.3	1.6	3.6	-1.7	-1.3	-1.0	-1.2	-1.4	-1.3	-1.9	-0.8	-1.1	-1.6	-1.5	-1.0	0.1	-1.4	-1.1	-1.4	-1.1	-0.9	-1.4
Loneliness, isolation	1.3	1.8	5.1	-1.1	-1.1	-1.1	-1.3	-1.2	-1.2	-1.5	0.9	-1.1	-1.3	-1.2	-1.4	2.2	-1.2	-1.3	-1.3	-1.4	-2.0	-1.2
Basal cell carcinoma (self-reported)	1.3	1.5	3.0	1.7	1.1	1.3	1.0	1.0	1.3	1.6	-0.0	1.7	1.6	1.5	1.1	0.1	1.3	0.9	1.3	1.2	0.5	1.3
Bipolar Disorder (2018)	1.2	1.9	3.1	-1.1	-1.4	-1.2	-1.4	-1.4	-1.7	-1.7	-0.4	-1.8	-1.4	-1.4	-1.5	0.3	-1.4	-1.4	-1.4	-1.8	-0.2	-1.4
Crohns Disease (2012)	1.2	1.9	3.0	-1.7	-1.5	-1.6	-1.6	-1.5	-1.2	-1.2	0.8	-1.1	-1.6	-1.6	-1.7	-0.3	-1.4	-1.3	-1.4	-1.5	-0.6	-1.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.7	1.2	1.3	1.1	1.3	1.3	1.1	2.2	-0.1	0.8	1.2	1.2	1.1	0.0	1.2	1.3	1.2	1.1	-0.4	1.2
Sensitivity / hurt feelings	1.2	2.0	8.6	-1.5	-1.5	-1.2	-1.3	-1.1	-1.7	-0.7	-2.9	-0.1	-1.4	-1.4	-1.4	-0.0	-1.3	-1.3	-1.3	-1.1	-1.6	-1.4
Taking other prescription medications	1.2	1.9	7.4	-0.8	-1.3	-1.4	-1.4	-1.2	-1.7	-1.0	1.3	-0.5	-1.3	-1.4	-1.5	0.4	-1.3	-1.4	-1.3	-1.4	-2.7	-1.3
Medication: Cholesterol lowering	1.2	1.9	2.5	-1.6	-1.5	-1.5	-1.4	-1.5	-1.3	-1.1	-1.3	-1.4	-1.5	-1.5	-1.5	0.7	-1.5	-1.4	-1.5	-1.2	-0.8	-1.5
Medication: Paracetamol	1.2	1.9	3.6	1.8	1.5	1.5	1.6	1.6	1.0	1.2	1.3	0.7	1.2	1.2	1.9	-1.3	1.3	1.6	1.3	1.6	0.7	1.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.0	1.6	1.7	1.5	1.6	1.5	1.4	1.3	1.2	1.2	1.6	1.6	1.7	-0.3	1.5	1.6	1.5	1.2	0.6	1.6
Age at first live birth	1.2	2.2	7.8	1.5	1.1	1.1	1.3	1.2	1.4	1.0	-2.8	-0.1	1.2	1.3	1.3	-2.4	1.2	1.3	1.2	0.9	2.2	1.2
Pulse wave peak to peak time	1.2	1.4	4.4	-0.6	-1.2	-1.5	-1.4	-1.3	-0.9	-1.1	0.7	-0.8	-1.1	-1.0	-1.5	0.7	-1.2	-1.5	-1.2	-2.1	0.0	-1.1
Systolic Blood Pressure	1.1	5.6	7.1	-2.3	-2.6	-2.4	-2.6	-2.5	-2.5	-2.2	-1.4	-1.4	-2.5	-2.5	-2.6	1.9	-2.6	-2.7	-2.6	-2.6	-1.8	-2.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.3	1.2	1.3	1.4	1.4	1.3	1.0	1.3	1.2	0.6	1.1	1.1	1.5	0.0	1.3	1.4	1.3	1.4	-0.1	1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.4	-1.8	-1.5	-1.3	-1.4	-1.0	-1.2	-1.5	-2.1	-1.1	-1.3	-1.3	-1.5	-0.1	-1.4	-1.4	-1.4	-1.4	-0.1	-1.4
High blood pressure (siblings)	1.1	1.6	3.4	-0.8	-1.3	-1.4	-1.4	-1.2	-1.8	-1.8	0.7	-0.6	-0.9	-1.1	-1.5	0.5	-1.2	-1.4	-1.2	-1.1	-1.6	-1.2
Mineral and other dietary supplements	1.1	1.5	11.1	1.0	0.9	1.0	0.9	0.9	1.2	1.7	3.3	0.3	0.9	0.9	0.8	-1.4	0.9	0.9	0.9	0.6	1.1	0.9
Medication: Lisinopril	1.1	1.4	2.8	-0.7	-1.4	-1.7	-1.4	-1.2	-1.3	-0.7	0.2	-0.7	-1.4	-1.4	-1.3	0.5	-1.3	-1.5	-1.3	-1.0	-1.0	-1.4
Medication: Atorvastatin	1.1	1.3	2.2	-1.5	-1.1	-1.2	-1.2	-1.2	-1.0	-1.4	-0.9	-0.7	-0.9	-1.0	-1.4	-1.4	-1.2	-1.2	-1.2	-1.0	-0.9	-1.1
Myopia	1.1	1.5	8.3	0.9	1.2	1.0	1.3	1.2	1.2	0.3	-0.0	0.8	1.3	1.3	1.1	-0.6	1.3	1.3	1.3	0.8	2.9	1.3
Hair/balding pattern: Pattern 2	1.0	1.3	3.3	-1.4	-1.0	-1.0	-1.1	-0.8	-1.3	-1.1	-0.7	-1.3	-1.1	-1.0	-1.1	1.8	-1.0	-1.1	-1.0	-1.3	-0.9	-1.0
Forced vital capacity (FVC)	1.0	3.9	8.1	-2.9	-2.2	-2.5	-2.3	-2.3	-1.7	-1.3	-0.3	-1.9	-1.9	-2.0	-2.2	0.3	-2.2	-2.3	-2.2	-2.2	0.1	-2.1
Happiness	1.0	1.2	5.4	-0.5	-0.8	-0.9	-1.0	-0.8	-0.5	-0.5	2.3	-1.9	-1.0	-1.0	-1.0	-0.2	-1.0	-1.0	-1.0	-1.3	1.1	-1.0
Standing height	1.0	9.7	13.7	-3.7	-3.5	-3.2	-3.4	-3.2	-3.2	-2.5	-2.9	-2.8	-3.1	-3.2	-3.4	2.1	-3.3	-3.4	-3.3	-3.6	-0.7	-3.3
Health satisfaction	1.0	1.3	3.7	-1.4	-0.9	-1.0	-1.1	-0.9	-0.6	-1.9	1.5	-1.7	-1.2	-1.2	-1.0	0.3	-1.1	-1.1	-1.1	-1.1	-0.1	-1.1
Family relationship satisfaction	1.0	1.3	2.6	-0.6	-1.1	-0.9	-1.2	-1.0	-1.2	-0.3	1.1	-1.4	-1.3	-1.2	-1.4	1.1	-1.2	-1.2	-1.2	-1.6	-0.5	-1.2
Leg pain on walking	1.0	1.3	3.3	0.4	1.2	1.1	1.3	1.7	0.4	-0.0	1.8	0.4	0.8	0.9	1.4	1.2	1.1	1.3	1.1	1.5	0.6	1.1
Whole body fat-free mass	1.0	5.9	7.5	-1.9	-2.5	-2.4	-2.6	-2.2	-2.7	-2.4	1.4	-2.7	-2.6	-2.6	-2.7	2.2	-2.7	-2.6	-2.7	-2.7	-1.1	-2.6
Whole body water mass	1.0	5.8	7.4	-1.9	-2.4	-2.4	-2.6	-2.2	-2.7	-2.3	1.4	-2.7	-2.6	-2.6	-2.7	2.2	-2.7	-2.5	-2.7	-2.7	-1.2	-2.6
Arm fat-free mass (left)	1.0	5.1	6.9	-1.7	-2.2	-2.2	-2.4	-2.0	-2.6	-2.3	1.5	-2.3	-2.4	-2.5	-2.5	2.0	-2.5	-2.4	-2.5	-2.5	-1.3	-2.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.7	0.8	1.2	1.3	1.2	0.9	1.3	1.0	0.2	0.1	1.3	1.3	1.1	-0.3	1.3	1.2	1.3	1.1	0.5	1.3
Commuting to job workplace: Cycle	1.0	1.2	4.3	-1.1	-0.9	-1.1	-1.0	-0.6	-1.5	-0.5	1.0	-0.5	-1.1	-1.1	-0.9	1.7	-1.0	-0.9	-1.0	-0.9	-2.1	-1.0
Cholesterol lowering medication	1.0	1.5	3.1	-1.2	-1.3	-1.6	-1.4	-1.5	-1.0	-1.8	1.1	-0.4	-1.0	-1.1	-1.5	0.2	-1.1	-1.5	-1.2	-1.3	-1.0	-1.1
Arm predicted mass (left)	1.0	5.3	6.9	-1.9	-2.3	-2.2	-2.5	-2.0	-2.6	-2.3	1.7	-2.4	-2.5	-2.5	-2.5	2.1	-2.6	-2.4	-2.6	-2.5	-1.1	-2.5
Neuroticism (Nagel 2018)	0.9	2.0	8.3	-1.4	-1.3	-1.2	-1.2	-1.1	-1.8	-1.1	-2.9	-0.8	-1.4	-1.4	-1.3	0.4	-1.3	-1.2	-1.2	-1.4	-1.9	-1.3
Ulcerative Colitis	0.9	1.3	6.4	1.2	1.0	0.5	0.7	0.4	1.4	1.9	2.5	0.6	1.2	1.0	0.6	-1.4	0.8	0.6	0.8	0.4	1.1	0.9
Height	0.9	16.6	24.7	-4.5	-4.6	-4.3	-4.3	-4.3	-4.1	-3.8	-5.0	-2.4	-4.0	-4.0	-4.5	2.8	-4.1	-4.4	-4.2	-4.8	-1.3	-4.2
Lung FEV1/FVC ratio	0.9	4.7	8.2	2.5	2.2	2.1	2.1	2.0	2.6	1.0	-2.9	2.1	2.5	2.5	2.1	-0.7	2.4	2.1	2.3	2.3	1.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	2.9	1.5	1.6	1.5	1.6	1.6	1.4	1.0	0.7	0.9	1.7	1.6	1.5	-1.0	1.6	1.6	1.6	1.6	1.5	1.6
Lung cancer (father)	0.9	1.0	2.4	-1.6	-1.2	-1.0	-1.1	-0.8	-1.0	-0.4	-0.4	-0.3	-1.4	-1.3	-0.9	0.4	-1.3	-1.0	-1.3	-0.9	-0.4	-1.3
Exposure to tobacco smoke at home	0.9	1.1	2.7	0.7	1.1	1.1	1.1	0.9	1.1	0.1	1.3	1.6	1.1	1.1	1.0	0.6	1.1	1.1	1.1	0.6	-0.6	1.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.0	-0.7	-0.8	-1.0	-0.9	-0.7	-1.3	-1.7	-1.3	-0.4	-0.9	-0.9	-1.0	-0.7	-0.9	-0.9	-0.9	-1.2	-1.7	-0.9
Arm fat-free mass (right)	0.9	4.6	6.4	-1.7	-2.1	-2.0	-2.2	-1.8	-2.5	-2.5	1.2	-2.2	-2.3	-2.3	-2.3	2.1	-2.4	-2.2	-2.3	-2.2	-1.3	-2.3
Arm predicted mass (right)	0.9	4.7	6.3	-1.9	-2.1	-2.1	-2.2	-1.9	-2.5	-2.5	1.3	-2.3	-2.4	-2.4	-2.3	2.1	-2.4	-2.2	-2.4	-2.2	-1.2	-2.3
Hearing aid user	0.9	1.0	1.6	1.0	1.1	0.7	1.2	1.2	1.2	0.8	-0.7	-0.1	1.0	1.0	1.2	0.1	1.1	1.2	1.1	1.2	-0.7	1.1
Leg fat percentage (left)	0.9	3.2	7.1	2.7	2.1	2.1	1.9	2.1	1.1	1.8	1.8	1.4	1.8	1.8	1.9	-0.0	1.8	1.9	1.8	1.9	-0.5	1.9
Supplements: Calcium	0.9	0.9	1.5	0.8	1.1	1.1	1.1	1.1	1.2	0.2	-0.2	0.3	1.0	1.1	1.0	0.9	1.1	1.1	1.1	1.2	0.6	1.1
Depression (Nagel 2018)	0.8	1.2	3.5	-0.8	-0.9	-0.8	-0.8	-0.6	-1.1	-1.6	0.8	-0.7	-1.4	-1.2	-1.0	1.9	-1.0	-0.7	-1.0	-1.2	-1.1	-1.0
Intelligence (Savage-Jansen 2018)	0.8	2.4	5.8	-0.8	-1.5	-1.4	-1.4	-1.7	-1.8	-1.1	-1.8	-1.8	-1.4	-1.3	-1.5	2.4	-1.4	-1.4	-1.4	-1.8	-1.4	-1.4
Relative age of first facial hair	0.8	1.7	2.8	-1.6	-1.6	-1.2	-1.4	-1.3	-0.9	-1.0	-1.2	-1.2	-1.3	-1.3	-1.5	0.0	-1.3	-1.4	-1.3	-1.7	-0.5	-1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.0	1.2	1.2	0.7	1.0	1.4	1.4	0.3	1.0	1.1	1.1	1.1	1.0	-0.1	1.1	1.0	1.1	1.0	-0.3	1.1
Medication: Levothyroxine sodium	0.8	1.4	3.1	1.1	1.2	0.7	1.1	1.2	1.1	1.1	1.8	-0.1	1.4	1.3	1.0	-0.3	1.4	1.0	1.4	1.0	1.4	1.4
Nervous feelings	0.8	1.5	4.2	-1.1	-1.2	-1.2	-1.2	-1.4	-1.5	-0.7	-2.1	-0.5	-1.3	-1.3	-1.2	-0.7	-1.2	-1.1	-1.2	-1.3	-1.1	-1.2
Pulse wave Arterial Stiffness index	0.8	0.9	3.2	0.2	1.0	1.3	1.2	1.1	0.7	0.8	-0.8	0.5	0.8	0.8	1.3	-0.6	0.9	1.2	0.9	1.8	0.1	0.9
Loud music exposure frequency	0.8	0.9	3.4	-0.7	-0.7	-0.8	-0.8	-0.8	-0.5	-0.3	1.8	-1.4	-1.0	-0.9	-0.8	0.2	-1.0	-0.8	-1.0	-1.3	-1.0	-0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	-1.2	-1.1	-1.3	-1.1	-1.1	-1.3	-0.8	-1.2	-0.8	-0.8	-0.9	-1.1	0.4	-0.9	-1.1	-0.9	-1.0	-0.7	-1.0
Alcohol drinker status: Never	0.8	0.9	2.7	1.6	0.9	0.7	0.7	0.8	0.7	0.9	1.6	0.6	0.9	0.9	0.6	-1.3	0.9	0.7	0.8	0.9	0.8	0.9
Basal metabolic rate	0.8	4.6	6.2	-1.5	-2.1	-2.1	-2.3	-1.9	-2.5	-2.1	1.4	-2.5	-2.3	-2.3	-2.4	2.1	-2.4	-2.3	-2.4	-2.4	-1.1	-2.3
Crohns Disease (2017)	0.7	1.5	4.9	-0.7	-1.1	-1.3	-1.3	-1.4	-0.9	-1.2	1.7	-2.2	-1.0	-1.1	-1.4	-1.0	-1.1	-1.3	-1.1	-1.2	-0.4	-1.1
Age at First Birth	0.7	1.0	3.3	1.2	1.0	1.0	1.0	1.2	1.1	1.8	0.2	0.6	1.0	1.1	1.1	0.5	1.0	1.0	1.0	0.7	0.8	1.0
Primary Biliary Cirrhosis	0.7	0.9	4.3	-1.0	-0.8	-0.9	-0.9	-0.7	-0.8	-1.1	-0.5	-2.1	-0.8	-0.7	-1.0	0.1	-0.9	-0.9	-0.9	-1.2	-1.0	-0.8
Blood Platelet Count	0.7	8.3	12.5	3.2	3.5	1.9	3.2	2.9	2.7	2.6	2.8	3.0	3.0	3.1	3.3	0.1	3.1	3.2	3.1	3.0	1.5	3.2
Medication: Co-codamol	0.7	0.8	1.7	0.7	1.0	1.0	1.1	1.1	0.4	0.3	1.0	0.5	0.7	0.7	1.0	-0.2	0.9	1.2	0.9	1.3	1.1	0.9
Leg fat-free mass (left)	0.7	3.7	5.1	-1.3	-1.9	-1.8	-2.0	-1.7	-2.2	-1.9	1.5	-2.3	-2.0	-2.0	-2.2	2.1	-2.1	-2.0	-2.1	-2.2	-1.0	-2.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.1	-0.6	-0.8	-0.8	-0.8	-0.5	-0.8	-0.8	-0.1	-1.2	-0.8	-0.7	-0.7	1.0	-0.8	-0.8	-0.8	-0.8	-1.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	6.2	-0.7	-0.4	-0.4	-0.3	-0.3	-0.2	-0.3	-1.0	1.7	-0.5	-0.4	-0.3	2.5	-0.3	-0.3	-0.3	-0.7	-1.6	-0.3
Stomach or abdominal pain in last month	0.7	0.9	1.6	0.2	1.1	1.0	1.1	1.1	1.0	-0.4	0.3	1.3	0.8	1.0	1.0	1.0	1.1	1.1	1.1	1.0	0.5	1.1
Leg predicted mass (left)	0.7	3.7	5.1	-1.3	-1.9	-1.8	-2.0	-1.7	-2.2	-1.9	1.4	-2.3	-2.0	-2.0	-2.2	2.1	-2.1	-2.0	-2.1	-2.2	-1.0	-2.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.4	0.8	1.0	1.0	1.0	1.1	0.9	0.4	0.3	0.8	1.1	1.0	1.2	-0.7	1.1	1.0	1.1	1.1	0.6	1.0
Fluid intelligence score	0.7	1.5	3.9	-0.7	-1.2	-1.2	-1.2	-1.2	-1.1	-1.0	-1.6	-0.6	-0.9	-0.9	-1.3	2.0	-1.0	-1.3	-1.0	-1.7	-1.4	-1.0
Neuroticism score	0.7	1.4	3.3	-1.0	-1.3	-1.0	-1.2	-1.0	-1.4	-1.2	-1.8	-0.7	-1.2	-1.2	-1.2	-0.2	-1.2	-1.2	-1.2	-1.1	-1.4	-1.2
Worrier / anxious feelings	0.7	1.3	16.8	-0.3	-0.7	-0.5	-0.4	-0.4	-0.5	-0.6	-4.1	-0.2	-0.4	-0.4	-0.6	-1.4	-0.4	-0.4	-0.4	-0.4	-1.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.0	-2.2	-1.7	-1.9	-1.8	-1.8	-1.0	-1.3	-0.4	-1.4	-1.4	-1.5	-1.7	0.4	-1.7	-1.8	-1.7	-1.8	0.4	-1.6
Wheeze or whistling in the chest in last year	0.7	1.2	8.7	-0.4	-0.7	-0.2	-0.8	-0.7	-1.1	-0.9	2.9	-1.7	-1.0	-1.0	-1.0	-1.2	-0.8	-0.8	-0.8	-1.0	-0.1	-0.9
Chest pain or discomfort	0.7	0.9	10.6	-0.1	-0.4	-0.3	-0.5	-0.1	-0.4	-0.1	3.3	-1.7	-0.5	-0.6	-0.4	-0.8	-0.5	-0.5	-0.5	-0.3	-1.2	-0.5
Osteoarthritis (self-reported)	0.7	0.9	3.1	-1.0	-0.8	-1.0	-0.8	-0.8	-1.2	-0.5	-0.6	-1.8	-1.0	-0.9	-0.7	0.4	-0.9	-0.8	-0.9	-0.8	-1.0	-0.9
Financial situation satisfaction	0.7	0.9	4.8	0.4	0.9	1.0	0.6	0.7	1.1	0.2	1.5	-0.0	0.7	0.6	0.8	-1.4	0.7	0.6	0.7	0.7	2.2	0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	5.2	-1.0	-0.7	-0.6	-0.6	-0.6	-1.0	-1.8	-2.3	-0.4	-0.8	-0.8	-0.4	0.7	-0.8	-0.6	-0.7	-0.2	-1.2	-0.8
Medication: Paracetamol	0.7	1.1	2.1	1.5	1.0	0.9	1.1	1.0	0.7	0.9	1.4	1.2	0.8	0.8	1.3	-1.2	0.8	1.1	0.8	1.3	-0.2	0.9
Heart disease (siblings)	0.7	0.8	2.3	-0.8	-0.8	-1.0	-0.8	-1.1	-0.8	-1.5	0.2	-1.5	-0.6	-0.8	-0.8	-1.0	-0.9	-0.8	-0.9	-0.6	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	10.8	-0.1	-0.1	0.0	0.0	0.1	-0.1	-1.3	-1.2	1.1	-0.2	-0.1	0.0	3.3	-0.0	0.1	0.0	-0.3	-1.1	-0.0
Breast Cancer	0.6	1.4	4.9	-0.4	-1.3	-1.3	-1.2	-0.9	-1.5	-0.6	-1.0	-0.3	-1.3	-1.3	-1.2	0.3	-1.2	-1.2	-1.2	-0.9	-2.2	-1.3
Cardiovascular Disease	0.6	1.8	3.0	-1.7	-1.4	-1.3	-1.5	-1.5	-1.5	-1.6	0.4	0.2	-1.5	-1.5	-1.7	-0.1	-1.5	-1.5	-1.5	-1.5	-0.5	-1.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.7	-0.4	-0.9	-0.5	-0.8	-0.4	-1.2	-1.6	0.4	-1.1	-1.2	-1.1	-0.9	0.8	-1.0	-0.7	-1.0	-1.1	-0.4	-1.0
Relative age voice broke	0.6	0.9	1.9	-1.1	-1.1	-0.6	-1.1	-1.1	-0.6	-1.0	-0.9	-1.1	-0.8	-0.8	-1.1	-1.1	-0.9	-1.1	-0.9	-1.4	0.5	-0.9
Supplements: Glucosamine	0.6	0.8	6.5	-0.6	-0.7	-0.6	-0.6	-0.4	-0.8	-1.3	-2.5	-1.2	-0.5	-0.5	-0.5	-0.3	-0.5	-0.6	-0.5	-0.4	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	1.5	0.9	1.0	1.0	0.7	0.5	0.4	0.0	0.7	0.8	0.9	1.0	-0.0	0.9	1.0	0.9	0.7	0.8	0.9
Qualifications: None of the above	0.6	1.2	2.4	1.6	1.2	1.2	1.3	1.0	0.5	1.3	0.4	0.3	1.0	1.1	1.2	1.4	1.1	1.3	1.1	1.1	-0.5	1.1
Medication: Simvastatin	0.6	0.9	1.7	-0.9	-1.0	-1.1	-1.0	-1.0	-0.8	-1.1	0.3	-0.6	-0.9	-0.9	-1.0	1.1	-0.8	-1.0	-0.8	-0.8	-1.3	-0.9
Falls in the last year	0.6	0.9	6.3	1.0	0.8	0.7	0.8	1.0	0.4	0.5	2.5	1.3	0.2	0.4	1.0	-0.1	0.6	0.9	0.7	0.9	0.5	0.6
Asthma	0.6	1.3	7.4	0.8	0.9	1.0	0.8	1.0	0.8	2.1	2.7	0.1	0.7	0.7	0.7	-1.5	0.8	0.8	0.8	0.8	0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.1	0.5	1.2	0.8	1.1	1.2	0.3	0.1	1.8	-0.2	0.7	0.8	1.1	0.3	0.9	1.2	0.9	0.9	0.0	0.9
Forced vital capacity (FVC), Best measure	0.6	2.0	5.4	-2.3	-1.5	-1.8	-1.6	-1.4	-1.0	-0.6	-0.0	-1.8	-1.3	-1.4	-1.5	0.7	-1.5	-1.6	-1.5	-1.7	0.4	-1.5
Leg fat percentage (right)	0.6	2.2	5.4	2.3	1.7	1.7	1.5	1.8	0.7	1.3	1.5	0.9	1.5	1.5	1.6	-0.2	1.4	1.5	1.5	1.5	-0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	8.2	-0.4	-0.5	-0.4	-0.5	-0.3	-0.3	-1.2	0.1	0.8	-0.3	-0.5	-0.5	-2.9	-0.4	-0.5	-0.4	-0.4	-0.7	-0.5
Supplements: Vitamin C	0.6	0.7	2.0	-0.7	-0.7	-0.8	-0.8	-0.6	-0.6	-1.3	-0.8	-1.0	-0.7	-0.6	-0.7	0.8	-0.6	-0.8	-0.6	-0.8	-1.4	-0.7
Leg fat-free mass (right)	0.6	3.1	4.4	-1.2	-1.7	-1.6	-1.8	-1.5	-1.9	-1.6	1.8	-2.1	-1.8	-1.8	-2.0	2.1	-1.9	-1.8	-1.9	-1.9	-0.7	-1.8
Qualifications: nursing, teaching	0.6	1.0	1.8	-1.0	-0.9	-1.0	-1.1	-1.1	-0.7	-0.1	1.4	-1.2	-0.8	-0.9	-1.3	1.0	-0.9	-1.1	-1.0	-1.2	-0.0	-0.9
Asthma (self-reported)	0.6	1.2	9.2	0.7	0.8	0.9	0.6	0.9	0.5	2.1	3.0	-0.5	0.5	0.5	0.5	-1.8	0.6	0.6	0.6	0.6	0.7	0.6
Medication: Aspirin	0.6	0.8	1.2	-1.1	-1.0	-1.1	-0.9	-0.8	-1.0	-1.1	-0.5	0.5	-1.0	-1.0	-0.9	0.4	-1.0	-0.9	-1.0	-0.5	-0.7	-1.0
Leg predicted mass (right)	0.6	3.0	4.2	-1.1	-1.6	-1.6	-1.8	-1.5	-1.8	-1.6	1.9	-2.0	-1.8	-1.7	-1.9	2.1	-1.8	-1.8	-1.8	-1.9	-0.7	-1.8
Commuting to job workplace: Public transport	0.6	0.7	1.8	1.0	0.9	0.6	0.8	0.7	1.1	1.4	0.8	-0.1	1.0	1.0	0.6	-0.5	0.8	0.7	0.8	0.8	0.9	0.9
Depressed Affect (Nagel 2018)	0.5	1.0	4.9	-0.7	-0.8	-0.8	-0.8	-0.7	-1.2	-0.7	-0.5	-0.3	-1.0	-0.9	-0.9	2.2	-0.8	-0.8	-0.8	-1.2	-1.3	-0.9
Number of treatments/medications taken	0.5	0.9	5.3	-0.1	-0.9	-0.8	-0.9	-1.0	-0.8	-0.5	0.7	-0.6	-0.8	-0.9	-1.0	-0.1	-0.9	-0.9	-0.9	-0.8	-2.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	-0.8	-0.9	-1.1	-0.9	-0.9	-1.3	-0.3	-0.7	-0.5	-0.7	-0.7	-0.8	0.1	-0.8	-0.9	-0.8	-0.7	-0.0	-0.8
Townsend deprivation index at recruitment	0.5	0.7	2.0	1.1	0.8	0.8	0.8	1.2	0.3	1.3	1.4	0.5	0.6	0.6	0.9	0.3	0.6	0.8	0.7	0.7	0.1	0.7
Sitting height	0.5	3.8	6.0	-2.5	-2.1	-2.1	-2.2	-2.0	-2.0	-1.3	-0.2	-1.7	-2.0	-2.0	-2.2	1.8	-2.1	-2.2	-2.2	-2.3	-0.5	-2.1
Impedance of leg (left)	0.5	2.3	8.5	0.3	1.2	1.3	1.4	1.2	1.4	1.4	-2.9	2.0	1.4	1.4	1.6	-1.8	1.4	1.3	1.4	1.4	0.9	1.4
Financial difficulties in last 2 years	0.5	0.7	7.3	0.6	0.7	0.6	0.4	0.5	0.7	0.0	2.7	-1.1	0.4	0.4	0.2	-0.5	0.3	0.4	0.3	0.6	0.9	0.4
Hip circumference	0.5	1.9	4.4	-0.2	-1.1	-1.0	-1.3	-0.8	-1.8	-1.3	1.2	-2.1	-1.3	-1.2	-1.5	2.0	-1.3	-1.3	-1.3	-1.5	-1.9	-1.2
Time employed in main current job	0.5	0.5	8.7	0.1	-0.2	0.0	-0.2	-0.4	0.2	0.4	-0.1	0.4	-0.1	-0.3	-0.2	-3.0	-0.2	-0.2	-0.2	0.0	-0.7	-0.2
Impedance of arm (left)	0.5	2.1	9.5	0.7	1.0	1.3	1.2	1.0	1.6	1.8	-3.1	0.9	1.4	1.4	1.3	-1.6	1.4	1.2	1.4	1.2	1.4	1.3
Tense / ‘highly strung’	0.5	0.8	1.8	-0.5	-0.9	-0.6	-0.8	-0.8	-1.1	-0.8	-1.3	-0.2	-0.9	-0.9	-0.8	-1.1	-0.8	-0.8	-0.8	-0.8	-1.4	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	6.1	-0.0	-0.3	-0.1	-0.5	-0.5	-0.2	1.2	1.4	0.0	-0.2	-0.4	-0.5	-2.5	-0.5	-0.5	-0.5	-0.4	-0.5	-0.4
Body fat percentage	0.5	2.1	4.6	2.1	1.7	1.8	1.6	1.9	0.9	1.2	1.4	0.8	1.5	1.5	1.5	0.0	1.5	1.6	1.5	1.5	-0.5	1.6
Mean time to correctly identify matches	0.5	0.9	1.7	-1.3	-1.0	-0.6	-0.9	-1.0	-1.2	-0.8	-0.6	-1.3	-1.1	-1.1	-1.0	-0.3	-1.0	-0.9	-1.0	-1.0	-0.3	-1.0
Smoking status: Previous	0.5	0.8	4.0	1.3	0.8	0.7	0.6	0.9	0.5	0.6	2.0	-0.5	1.0	0.9	0.4	-0.4	0.9	0.6	0.8	0.5	0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	5.1	-1.7	-0.6	-0.7	-0.5	-0.4	-0.6	-0.6	-1.7	-0.6	-0.3	-0.5	-0.5	-2.3	-0.6	-0.5	-0.6	-0.7	-0.2	-0.6
Number of self-reported non-cancer illnesses	0.5	1.0	6.7	-0.7	-0.8	-0.8	-0.8	-0.6	-1.1	-0.5	2.6	-0.8	-0.8	-0.9	-1.0	-0.8	-0.7	-0.8	-0.7	-1.0	-0.0	-0.8
Average weekly champagne plus white wine intake	0.5	0.6	4.0	0.0	0.6	0.7	0.5	0.2	1.1	0.5	0.6	0.4	0.8	0.7	0.4	-1.5	0.6	0.5	0.6	0.5	2.0	0.6
Impedance of whole body	0.5	2.6	10.0	0.5	1.3	1.5	1.4	1.2	1.6	1.6	-3.2	1.7	1.6	1.6	1.6	-1.9	1.6	1.4	1.6	1.4	1.3	1.5
Alzheimer’s Disease (in mother)	0.4	0.4	4.8	0.6	0.3	0.3	0.3	0.3	0.2	-0.5	0.1	1.0	0.3	0.4	0.2	2.2	0.4	0.3	0.4	0.3	-0.9	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.1	0.0	-0.9	-0.9	-0.9	-1.1	-0.8	-0.2	-1.5	-0.4	-0.6	-0.6	-0.9	2.0	-0.6	-1.0	-0.7	-1.4	-0.9	-0.7
Ovarian Cancer	0.4	0.5	1.3	-0.6	-0.7	-0.5	-0.7	-0.7	-0.2	-0.4	0.5	-0.4	-0.7	-0.7	-0.6	-1.1	-0.7	-0.7	-0.7	-0.9	0.9	-0.7
LDL Cholesterol	0.4	0.6	1.6	-0.2	0.7	0.2	0.5	0.6	0.8	0.9	1.3	0.8	0.8	0.8	0.6	-0.6	0.7	0.5	0.7	0.7	-1.3	0.7
Lupus	0.4	0.6	2.2	0.8	0.7	1.0	0.7	0.6	0.8	1.5	0.4	0.6	1.0	0.9	0.7	-0.5	0.7	0.7	0.7	0.8	0.6	0.8
Lung FVC	0.4	1.8	3.4	-1.8	-1.6	-1.8	-1.6	-1.4	-1.0	-0.6	-0.7	-1.9	-1.1	-1.3	-1.4	0.6	-1.4	-1.6	-1.4	-1.6	-0.6	-1.4
Hand grip strength (left)	0.4	1.1	2.0	-0.6	-1.2	-1.2	-1.2	-1.4	-0.7	-0.5	0.4	-1.2	-1.1	-1.2	-1.3	-0.7	-1.2	-1.2	-1.2	-1.0	0.2	-1.2
Supplements: Zinc	0.4	0.5	4.1	-0.4	0.1	0.4	0.3	0.2	-0.1	-1.1	-1.0	-0.1	-0.3	-0.1	0.4	2.0	0.0	0.4	0.0	0.5	-1.3	-0.0
Severe depression (siblings)	0.4	0.5	3.2	-0.8	-0.3	-0.4	-0.4	-0.5	0.0	-1.8	-0.4	-1.2	-0.4	-0.4	-0.4	0.7	-0.4	-0.4	-0.4	-0.9	-0.3	-0.4
Maternal smoking around birth	0.4	0.6	1.9	1.1	0.8	0.8	0.9	0.8	0.4	-0.2	1.4	-0.9	0.4	0.5	0.8	-0.8	0.5	1.0	0.6	1.0	0.6	0.6
Had other major operations	0.4	0.5	3.9	-0.0	-0.5	-0.3	-0.4	-0.1	-0.8	-0.2	-2.0	-0.9	-0.5	-0.5	-0.4	0.0	-0.5	-0.4	-0.5	-0.4	-1.2	-0.5
Mouth/teeth dental problems	0.4	0.6	3.1	-0.5	-0.7	-0.8	-0.7	-0.8	-0.3	-0.3	0.1	-0.0	-1.0	-0.9	-0.7	1.8	-0.8	-0.7	-0.8	-0.5	-0.6	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	4.3	0.5	0.2	0.5	0.1	0.2	0.5	0.8	2.1	-0.5	0.4	0.4	-0.0	-1.4	0.3	0.1	0.3	0.4	0.2	0.3
Illnesses of siblings	0.4	0.5	3.1	-0.0	0.7	0.9	0.7	0.8	1.1	1.8	-0.0	0.6	0.3	0.5	0.7	0.8	0.6	0.7	0.6	0.3	0.5	0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	8.5	-0.1	-0.5	-0.7	-0.7	-0.6	-0.2	-0.3	-0.0	-2.9	-0.3	-0.3	-0.8	2.1	-0.5	-0.8	-0.5	-0.8	-0.5	-0.5
Depression (self-reported)	0.4	0.5	0.8	-0.8	-0.7	-0.3	-0.7	-0.6	-0.9	0.9	-0.1	-0.7	-0.8	-0.8	-0.6	-0.7	-0.8	-0.6	-0.8	-0.7	-0.0	-0.8
Length of working week for main job	0.4	0.5	1.4	-0.5	-0.5	-0.6	-0.6	-0.5	-0.3	-0.5	1.1	-1.2	-0.9	-0.9	-0.7	-0.4	-0.9	-0.6	-0.8	-0.4	0.3	-0.8
Peak expiratory flow (PEF)	0.4	0.9	3.3	-1.0	-0.9	-0.8	-0.9	-1.2	-0.7	-0.7	0.8	-1.8	-0.7	-0.8	-0.9	-0.9	-0.9	-1.0	-0.9	-0.9	0.4	-0.8
Medication: Omeprazole	0.4	0.4	3.5	0.4	0.3	-0.2	0.1	0.2	0.3	0.8	1.9	0.6	0.4	0.3	-0.0	-0.9	0.4	0.1	0.3	0.0	-1.4	0.3
Alcohol intake frequency.	0.4	0.8	3.9	-0.5	-0.7	-1.1	-0.9	-0.8	-0.8	0.2	1.7	0.1	-0.6	-0.7	-0.8	-0.7	-0.7	-0.9	-0.8	-0.7	-2.0	-0.7
Number of full sisters	0.4	0.5	2.7	0.1	-0.6	-0.8	-0.6	-0.4	-1.1	0.1	-0.0	-0.4	-0.6	-0.6	-0.6	1.6	-0.7	-0.6	-0.7	-0.7	-0.7	-0.7
Suffer from ‘nerves’	0.4	0.6	1.1	0.6	0.9	1.1	1.0	0.8	0.3	0.9	0.1	0.4	0.5	0.6	1.1	0.2	0.8	1.1	0.9	0.8	-0.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	5.1	-0.5	-0.5	-0.4	-0.4	-0.5	-0.6	-0.2	-2.3	0.3	-0.4	-0.3	-0.4	0.7	-0.4	-0.4	-0.4	-0.5	-0.4	-0.4
Medication: Aspirin	0.4	0.6	1.6	-1.1	-0.7	-0.8	-0.7	-0.6	-0.6	-1.3	-1.0	0.7	-0.8	-0.8	-0.7	0.3	-0.8	-0.7	-0.8	-0.4	-0.3	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	2.4	1.5	0.7	0.7	0.7	0.6	0.4	0.2	0.5	-0.0	0.9	0.8	0.6	-0.2	0.7	0.6	0.7	1.1	0.4	0.7
Arm fat percentage (left)	0.4	1.6	4.5	2.1	1.5	1.5	1.3	1.5	0.7	1.0	1.9	0.1	1.2	1.2	1.2	0.3	1.2	1.3	1.2	1.2	-0.3	1.3
Commuting to job workplace: Walk	0.4	0.5	1.2	0.3	0.7	0.8	0.7	0.7	0.9	0.5	1.0	-0.3	0.6	0.5	0.7	0.2	0.5	0.8	0.6	0.8	1.1	0.6
Medication for cholesterol	0.4	0.6	1.7	0.6	0.7	0.8	0.8	0.7	0.5	0.9	-1.3	0.7	0.6	0.7	0.9	-0.4	0.7	0.8	0.7	1.0	0.7	0.7
Medication: Gliclazide	0.4	0.4	0.9	-0.6	-0.8	-0.9	-0.7	-0.8	-0.6	-0.2	0.2	-1.0	-0.6	-0.7	-0.7	-0.2	-0.8	-0.7	-0.8	-0.6	0.1	-0.7
Medication: Blood pressure	0.4	0.7	1.4	-0.5	-0.9	-0.8	-1.0	-1.0	-0.6	-0.7	1.1	-0.8	-0.7	-0.8	-1.0	0.5	-0.8	-1.0	-0.8	-1.0	-1.2	-0.8
Medication: Bendroflumethiazide	0.4	0.6	2.0	-1.2	-0.7	-0.5	-0.6	-0.4	-0.7	-1.4	-0.9	-0.5	-0.9	-0.8	-0.7	-0.1	-0.6	-0.6	-0.6	-0.8	-0.4	-0.7
Average weekly beer plus cider intake	0.4	0.6	2.4	1.3	0.8	0.7	0.8	0.8	0.5	0.6	0.8	0.1	0.7	0.7	0.7	1.5	0.7	0.8	0.7	0.8	-0.1	0.7
Diastolic blood pressure, automated reading	0.4	1.1	3.2	-0.5	-1.0	-0.8	-1.0	-0.8	-1.4	-1.3	-0.4	0.2	-1.1	-1.1	-1.1	0.9	-1.1	-1.0	-1.1	-1.1	-1.8	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	5.9	0.2	0.2	-0.2	0.1	0.1	0.1	0.4	2.4	0.3	0.2	0.1	-0.2	-1.4	0.2	0.0	0.2	-0.1	-1.3	0.2
Worry (Nagel 2018)	0.3	0.6	6.1	-0.4	-0.3	-0.2	-0.2	-0.4	-0.5	-0.0	-2.5	-0.3	-0.4	-0.4	-0.1	-1.1	-0.2	-0.1	-0.2	-0.0	-1.6	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	3.8	0.2	-0.2	-0.2	-0.2	-0.2	-0.2	-0.9	-0.6	0.1	-0.5	-0.3	-0.3	2.0	-0.3	-0.1	-0.3	-0.6	0.3	-0.3
Irritable Bowel Disease (IBD)	0.3	0.8	7.4	0.5	0.5	-0.1	0.1	0.0	0.9	0.9	2.7	-0.9	0.7	0.5	0.0	-1.6	0.4	0.1	0.3	0.2	0.4	0.4
Prostate Cancer	0.3	0.5	6.4	-0.1	0.0	0.1	-0.0	0.0	0.2	-0.9	0.1	2.5	-0.1	-0.0	0.1	-0.0	-0.1	-0.0	-0.1	0.5	-1.1	-0.1
Fasting Glucose	0.3	0.3	3.9	-0.4	0.1	-0.1	0.1	-0.3	-0.3	0.1	0.8	0.1	-0.0	-0.1	-0.1	-2.0	-0.2	0.1	-0.2	0.3	1.1	-0.1
Neuroticism (2016)	0.3	0.4	1.2	0.8	0.5	0.4	0.4	0.4	0.9	-0.1	0.8	0.8	0.7	0.6	0.2	-1.1	0.5	0.4	0.5	0.5	0.9	0.5
Respiratory disease	0.3	0.7	2.7	-0.3	-0.8	-0.5	-0.9	-0.7	-0.7	0.1	1.7	-0.5	-0.7	-0.8	-1.0	-1.5	-0.8	-0.9	-0.8	-0.5	-0.6	-0.8
Chronotype (morning person)	0.3	0.6	3.5	-0.4	-0.8	-0.9	-0.7	-0.7	-0.2	-0.7	-1.9	0.2	-0.2	-0.3	-0.7	0.5	-0.4	-0.8	-0.4	-0.7	-1.6	-0.5
Diabetes (father)	0.3	0.4	2.4	0.2	0.2	-0.4	-0.0	-0.2	0.1	0.5	1.5	-0.7	0.5	0.3	-0.2	1.5	0.2	-0.1	0.2	-0.2	-0.8	0.2
Impedance of leg (right)	0.3	1.6	10.9	-0.0	0.8	0.9	1.0	0.8	0.9	0.9	-3.3	1.5	1.0	1.0	1.2	-1.8	1.1	1.0	1.1	1.0	0.5	1.0
Trunk fat percentage	0.3	1.3	3.3	1.8	1.3	1.5	1.2	1.5	0.6	1.0	0.7	0.4	1.1	1.2	1.1	-0.1	1.2	1.2	1.2	1.1	-0.4	1.2
Fed-up feelings	0.3	0.6	1.3	-0.8	-0.9	-0.8	-0.8	-0.5	-0.8	-1.1	-0.3	-1.0	-0.8	-0.9	-0.8	0.6	-0.7	-0.8	-0.7	-0.9	-0.6	-0.8
Age when periods started (menarche)	0.3	0.6	3.3	-0.8	-0.8	-0.9	-0.7	-0.8	-0.9	-0.8	-1.8	-0.5	-0.7	-0.7	-0.8	0.2	-0.7	-0.7	-0.7	-0.7	-0.2	-0.7
Waist circumference	0.3	1.2	3.8	0.2	-0.9	-0.7	-1.0	-0.5	-1.6	-1.0	0.7	-1.6	-0.9	-1.0	-1.3	1.0	-1.0	-1.1	-1.0	-1.0	-1.9	-1.0
Allergy	0.3	0.6	6.0	-0.3	-0.3	-0.7	-0.3	-0.7	0.0	-1.4	-2.5	-0.2	-0.1	-0.1	-0.2	1.1	-0.2	-0.3	-0.3	-0.6	-0.1	-0.2
Weight	0.3	1.7	3.2	-0.3	-1.1	-1.0	-1.2	-0.8	-1.7	-1.1	1.5	-1.6	-1.3	-1.2	-1.4	1.8	-1.3	-1.2	-1.3	-1.4	-1.3	-1.2
Impedance of arm (right)	0.3	1.4	7.3	0.3	0.8	0.9	0.9	0.7	1.2	1.5	-2.7	0.6	1.2	1.1	1.0	-1.7	1.1	0.9	1.1	0.8	1.2	1.0
Arm fat percentage (right)	0.3	1.2	4.7	1.8	1.2	1.2	1.0	1.3	0.5	1.0	2.2	-0.1	0.9	1.0	0.9	0.1	0.9	1.0	0.9	0.8	-0.5	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	2.1	-0.0	-0.5	-0.8	-0.4	-0.6	-0.4	-0.3	-1.4	1.0	-0.6	-0.5	-0.3	0.5	-0.5	-0.4	-0.5	-0.4	-1.0	-0.5
Prospective memory result	0.3	0.3	1.3	0.1	-0.6	-0.3	-0.6	-0.7	-0.7	-0.3	1.1	-0.5	-0.7	-0.6	-0.4	0.5	-0.6	-0.6	-0.6	-0.5	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.6	-1.6	-1.1	-1.3	-1.2	-1.1	-0.3	-0.2	-0.3	-1.2	-0.8	-0.9	-1.1	0.4	-1.1	-1.3	-1.1	-1.4	0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	4.0	0.6	0.6	-0.1	0.5	0.5	0.4	0.5	2.0	-0.2	0.8	0.7	0.5	-1.0	0.8	0.5	0.8	0.4	1.4	0.8
Medication: Amlodipine	0.3	0.4	1.0	-0.3	-0.7	-0.7	-0.8	-0.6	-0.6	-0.8	0.0	0.0	-0.5	-0.5	-0.8	0.8	-0.6	-0.8	-0.6	-1.0	-0.4	-0.6
Birth weight	0.3	0.7	2.0	-0.1	-0.9	-0.8	-0.9	-0.6	-1.0	-0.1	-1.1	-0.4	-0.7	-0.7	-1.0	1.4	-0.7	-1.0	-0.8	-1.0	-0.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	-0.9	-0.3	0.0	-0.4	-0.4	-1.1	-1.3	0.4	-0.7	-0.7	-0.6	-0.5	0.2	-0.6	-0.3	-0.6	-0.8	-0.3	-0.5
Number of children fathered	0.3	0.3	0.9	0.5	0.7	0.5	0.7	0.3	0.3	0.4	0.8	0.3	0.4	0.4	0.7	0.5	0.5	0.8	0.5	1.0	-0.3	0.5
Migraine (self-reported)	0.3	0.4	1.8	0.8	0.5	0.6	0.5	0.5	0.5	0.9	0.5	0.8	0.4	0.3	0.6	-1.3	0.4	0.5	0.4	0.9	0.2	0.4
Overall health rating	0.3	0.6	3.2	-0.4	-0.4	-0.6	-0.5	-0.2	-1.1	-1.6	1.8	-0.6	-0.6	-0.6	-0.6	0.1	-0.5	-0.4	-0.5	-0.3	-0.5	-0.5
Illnesses of father: Heart disease	0.3	0.4	3.5	0.1	-0.3	-0.6	-0.4	-0.4	-0.3	0.5	1.9	0.1	-0.2	-0.4	-0.4	-0.8	-0.3	-0.4	-0.3	-0.1	-0.7	-0.3
Eye problems/disorders: Cataract	0.3	0.3	2.1	-0.4	-0.5	-0.3	-0.4	-0.6	-0.3	0.2	-1.3	0.0	-0.5	-0.4	-0.4	1.4	-0.4	-0.4	-0.4	0.1	-0.8	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	2.6	0.1	0.6	0.9	0.6	0.7	0.4	0.1	-1.6	0.2	0.3	0.5	0.7	1.1	0.4	0.6	0.4	0.5	-0.0	0.5
Wears glasses or contact lenses	0.3	0.4	2.8	-0.1	-0.4	-0.2	-0.3	-0.3	-0.5	0.0	-0.4	-0.8	-0.1	-0.3	-0.5	-1.7	-0.2	-0.4	-0.2	-0.7	1.3	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	-0.9	-0.5	-0.3	-0.4	-0.3	-0.5	-1.1	-0.2	-0.7	-0.7	-0.7	-0.3	0.5	-0.6	-0.4	-0.6	-0.3	-0.8	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	5.0	0.2	0.3	0.2	0.1	0.1	0.5	0.6	2.2	-0.8	0.1	0.0	0.3	-0.8	0.1	0.2	0.1	-0.1	1.0	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	2.3	-0.6	-0.4	-0.3	-0.6	-0.4	-0.9	-1.5	0.4	-1.2	-0.9	-0.7	-0.7	0.6	-0.7	-0.5	-0.6	-0.8	0.3	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	1.7	-1.2	0.1	0.1	0.2	0.3	0.0	-0.7	-1.3	0.8	-0.0	0.1	0.3	0.5	0.1	0.2	0.1	-0.0	-0.3	0.1
Mean Putamen Volume	0.2	0.2	1.5	-1.2	-0.3	-0.4	-0.3	-0.2	-0.4	0.1	-0.2	-0.3	-0.4	-0.5	-0.0	0.2	-0.4	-0.2	-0.4	-0.2	0.5	-0.4
BMI	0.2	0.9	8.6	0.6	0.2	0.2	-0.1	0.2	-0.4	-0.4	2.9	-0.9	-0.3	-0.2	-0.2	2.1	-0.3	-0.0	-0.2	-0.1	-1.2	-0.1
Smoking Status	0.2	0.5	6.1	1.2	0.4	0.1	0.2	0.4	-0.1	0.9	2.5	-0.7	0.4	0.3	-0.0	0.4	0.3	0.2	0.3	0.3	0.1	0.3
Allergy or Eczema	0.2	0.5	2.9	0.5	0.3	1.0	0.3	0.5	0.2	1.2	1.7	0.9	0.3	0.3	0.3	-0.6	0.4	0.3	0.4	0.6	0.2	0.4
Tanning	0.2	2.7	3.7	-1.4	-1.7	-1.6	-1.8	-1.7	-1.8	-1.7	1.0	-1.0	-1.9	-1.9	-1.7	1.9	-1.7	-1.7	-1.7	-1.5	-1.7	-1.7
Hearing difficulty/problems: Yes	0.2	0.2	2.1	0.2	0.2	0.3	0.4	0.3	0.2	-0.1	-1.0	-0.2	0.2	0.2	0.4	-0.4	0.3	0.4	0.3	0.5	-1.5	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	0.3	0.7	0.5	0.6	0.7	0.3	-0.2	1.0	-0.1	0.4	0.5	0.7	0.0	0.5	0.6	0.5	0.6	-0.1	0.5
Medication: Metformin	0.2	0.3	1.8	0.5	0.3	0.1	0.4	0.3	0.2	-0.8	0.3	-0.5	0.4	0.4	0.3	1.4	0.3	0.4	0.3	0.0	0.7	0.4
Average weekly fortified wine intake	0.2	0.2	1.1	0.7	0.1	0.3	0.1	-0.0	0.6	0.8	-0.6	0.9	0.2	0.2	0.1	-1.1	0.2	0.1	0.2	-0.0	0.5	0.2
Qualifications: CSEs or equivalent	0.2	0.3	2.3	0.5	0.4	0.1	0.3	0.5	0.3	-0.6	1.5	0.9	0.5	0.4	0.2	0.1	0.4	0.3	0.4	0.4	-0.2	0.4
Body mass index (BMI)	0.2	0.7	8.6	1.4	0.5	0.5	0.3	0.6	-0.3	0.1	2.9	-0.4	0.1	0.2	0.1	0.8	0.2	0.3	0.2	0.2	-1.0	0.2
Past tobacco smoking	0.2	0.5	2.0	-1.1	-0.6	-0.6	-0.4	-0.7	-0.2	-0.7	-1.4	0.4	-0.8	-0.7	-0.2	0.8	-0.6	-0.4	-0.6	-0.4	-0.6	-0.6
Had menopause	0.2	0.3	0.9	-0.3	-0.5	-0.6	-0.5	-0.6	-0.7	-0.8	-0.1	-0.1	-0.4	-0.5	-0.3	0.3	-0.5	-0.5	-0.5	0.0	-1.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.8	0.7	0.7	0.7	0.7	0.4	-0.1	0.5	-0.1	0.8	0.7	0.6	-0.9	0.7	0.7	0.7	0.4	1.2	0.7
Diabetes (self-reported)	0.2	0.4	1.8	0.8	0.5	0.2	0.5	0.6	0.5	-0.4	0.7	0.5	0.7	0.6	0.3	1.4	0.6	0.4	0.5	0.6	0.1	0.6
Father’s age at death	0.2	0.3	3.3	0.2	0.1	0.1	0.1	-0.2	0.4	-0.0	-1.8	0.1	0.3	0.2	0.1	0.9	0.1	0.0	0.1	-0.3	-0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	2.0	0.1	-0.1	0.1	-0.2	-0.1	-0.7	-1.1	1.4	-0.8	-0.4	-0.4	-0.4	0.3	-0.3	-0.2	-0.3	-0.4	-0.5	-0.3
Pulse wave reflection index	0.2	0.3	1.1	0.1	0.4	0.5	0.4	0.0	0.4	1.0	-0.1	0.9	0.4	0.4	0.5	0.9	0.4	0.4	0.4	0.5	0.2	0.4
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.7	0.5	0.3	0.5	0.7	0.2	0.0	1.0	-0.6	0.4	0.4	0.4	0.8	0.5	0.5	0.5	0.6	0.5	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.8	0.3	0.2	0.5	0.3	0.6	0.2	0.8	-1.0	0.2	0.2	0.3	0.4	-1.4	0.2	0.3	0.2	0.2	0.3	0.2
Number of full brothers	0.2	0.3	1.3	1.0	0.5	0.2	0.5	0.3	0.3	0.4	0.8	-0.4	0.2	0.4	0.6	1.1	0.3	0.5	0.4	0.8	0.2	0.4
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.2	-0.5	-0.3	-0.4	-0.5	-0.8	-0.3	0.8	-0.2	-0.6	-0.6	-0.2	0.3	-0.4	-0.4	-0.4	-0.1	-0.1	-0.5
Eye problems/disorders: None of the above	0.2	0.3	2.6	0.5	0.4	0.3	0.3	0.2	0.4	0.0	0.1	0.1	0.5	0.5	0.1	-1.6	0.4	0.2	0.4	-0.1	0.8	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	2.3	-0.7	-0.6	-0.3	-0.6	-0.7	-0.1	-0.0	-1.5	-0.4	-0.2	-0.2	-0.8	0.4	-0.3	-0.6	-0.4	-0.6	0.6	-0.4
Medication: Ibuprofen	0.2	0.3	3.1	-0.3	0.3	-0.1	0.2	0.2	-0.3	-0.5	1.8	-0.7	-0.1	-0.0	0.2	0.3	-0.0	0.2	0.0	-0.0	-0.6	0.1
Comparative height size at age 10	0.2	1.0	3.4	-1.1	-1.0	-0.9	-1.0	-0.8	-1.2	-0.3	-1.8	-1.0	-0.8	-0.8	-1.0	1.3	-1.0	-1.0	-1.0	-1.2	0.3	-1.0
Had major operations	0.2	0.2	1.2	0.5	0.2	-0.0	0.2	0.2	0.4	0.4	-0.9	0.7	0.3	0.3	0.2	-1.1	0.2	0.1	0.2	0.2	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.7	-0.4	-0.4	-0.6	-0.5	-0.5	0.1	1.3	0.8	-0.3	-0.2	-0.3	-0.7	1.0	-0.4	-0.6	-0.4	-0.9	0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.4	-0.7	-0.6	-0.6	-0.5	-0.5	0.5	0.6	0.1	-0.3	-0.5	-0.6	0.0	-0.5	-0.7	-0.5	0.0	0.3	-0.5
Mood swings	0.2	0.3	1.3	1.1	0.5	0.4	0.4	0.5	0.4	1.1	0.2	1.0	0.4	0.5	0.5	0.5	0.5	0.4	0.5	0.5	0.1	0.5
Friendships satisfaction	0.2	0.2	0.9	-0.0	-0.4	-0.5	-0.4	-0.4	-0.5	-0.5	0.9	-0.6	-0.3	-0.3	-0.6	-0.1	-0.3	-0.5	-0.3	-1.0	-0.1	-0.3
Back pain experienced in last month	0.2	0.3	2.2	-0.2	-0.3	-0.4	-0.3	-0.2	-0.2	0.5	1.5	-0.6	-0.4	-0.5	-0.2	1.0	-0.3	-0.3	-0.3	-0.2	-0.2	-0.3
Breast cancer (self-reported)	0.2	0.2	1.5	-0.1	-0.4	-0.5	-0.4	-0.2	-0.0	0.2	0.5	-0.5	-0.3	-0.3	-0.5	0.0	-0.3	-0.4	-0.3	-0.6	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	4.4	-0.4	0.3	0.1	0.3	0.4	0.3	0.3	-0.3	0.2	0.4	0.3	0.4	-2.1	0.3	0.3	0.3	0.2	1.8	0.3
Mother’s age at death	0.2	0.3	2.2	0.3	0.1	0.7	0.2	0.3	-0.1	-0.5	-0.7	-0.6	0.5	0.3	0.4	-1.5	0.5	0.2	0.4	0.4	0.7	0.3
High cholesterol (Self-reported)	0.2	0.3	1.5	-1.2	-0.4	-0.6	-0.5	-0.5	-0.2	-0.7	0.4	-0.6	-0.4	-0.3	-0.5	0.8	-0.3	-0.5	-0.3	-0.6	-0.1	-0.3
Illnesses of father: High blood pressure	0.2	0.2	1.2	0.4	0.4	0.1	0.3	0.3	0.1	0.4	1.1	-0.2	0.5	0.4	0.2	-1.1	0.4	0.3	0.4	0.2	0.2	0.4
Ever smoked	0.2	0.3	2.4	0.1	-0.4	-0.2	-0.4	-0.1	-0.8	-0.0	-0.0	-0.7	-0.1	-0.2	-0.6	-1.6	-0.3	-0.5	-0.3	-0.6	0.4	-0.3
Number of operations (self-reported)	0.2	0.2	0.8	0.9	0.4	0.4	0.4	0.5	0.3	0.4	-0.3	0.8	0.4	0.3	0.3	-0.9	0.3	0.4	0.3	0.3	-0.5	0.3
Ever depressed for a whole week	0.2	0.2	0.8	0.6	0.6	0.4	0.5	0.9	0.3	-0.9	0.1	-0.2	0.5	0.5	0.6	-0.0	0.5	0.5	0.5	0.3	-0.1	0.5
Pain experienced in last month	0.2	0.3	1.2	0.3	-0.5	-0.4	-0.5	-0.6	-0.7	-0.4	-1.1	0.1	-0.4	-0.4	-0.7	-0.2	-0.5	-0.5	-0.5	-0.6	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.5	0.7	0.4	0.2	0.4	0.6	0.2	-0.1	0.7	-0.6	0.3	0.4	0.3	1.2	0.4	0.4	0.4	0.5	0.3	0.4
Schizophrenia (2018)	0.1	0.2	0.7	-0.1	0.6	0.6	0.4	0.5	0.2	-0.7	0.8	-0.3	0.1	0.3	0.3	0.0	0.3	0.5	0.3	0.3	0.6	0.4
Reaction Time	0.1	0.2	0.9	-0.5	-0.2	0.2	-0.2	-0.2	-0.5	-0.4	0.8	-0.9	-0.3	-0.3	-0.3	-0.4	-0.3	-0.1	-0.3	-0.2	0.3	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.5	0.3	0.1	0.2	0.5	0.5	0.1	0.6	0.2	0.4	0.3	0.0	-0.4	0.4	0.2	0.3	0.1	0.2	0.3
HbA1C	0.1	0.1	1.3	0.2	-0.1	-0.0	-0.1	-0.1	-0.3	0.6	1.2	-0.3	-0.0	-0.1	-0.1	0.7	-0.0	-0.1	-0.0	0.1	-0.1	-0.1
Schizophrenia (2014)	0.1	0.2	1.6	-0.2	0.2	0.4	0.1	0.3	-0.3	-1.2	0.6	-0.6	-0.2	-0.1	-0.1	0.5	-0.0	0.1	0.0	-0.2	0.2	0.0
Triglycerides	0.1	0.1	0.5	-0.6	0.1	0.1	0.1	0.2	0.3	0.5	0.7	0.4	-0.2	-0.1	0.2	0.3	0.0	0.2	0.0	0.4	0.2	-0.0
Heel T-Score	0.1	0.5	3.5	0.4	-0.2	-0.6	-0.4	-0.5	-0.6	-0.3	1.5	-1.9	-0.2	-0.3	-0.7	-0.3	-0.4	-0.5	-0.4	-0.9	-0.4	-0.3
Waist Hip Ratio (WHR)	0.1	0.6	2.1	-0.8	-1.0	-0.8	-0.8	-0.7	-0.7	-0.3	-1.4	-0.3	-0.7	-0.9	-0.8	-1.0	-0.8	-0.8	-0.8	-0.4	-0.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	2.4	0.3	0.3	-0.1	0.2	0.1	0.4	-0.0	0.6	0.6	0.3	0.3	0.1	1.6	0.3	0.2	0.3	-0.1	0.1	0.3
Neuroticism	0.1	0.3	2.9	-0.4	-0.3	-0.2	-0.2	-0.1	-0.6	-0.8	-1.7	-0.1	-0.4	-0.3	-0.2	-0.1	-0.2	-0.2	-0.2	-0.2	-1.1	-0.3
Average weekly spirits intake	0.1	0.1	0.5	-0.3	-0.2	0.2	-0.1	-0.3	0.1	0.7	-0.7	-0.2	-0.1	-0.2	-0.0	0.3	-0.0	-0.1	-0.0	0.2	0.2	-0.1
Systolic blood pressure, automated reading	0.1	0.4	2.2	-0.0	-0.4	-0.2	-0.3	-0.2	-0.5	-0.5	-1.5	1.0	-0.3	-0.3	-0.5	0.5	-0.3	-0.3	-0.3	-0.2	-1.3	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.6	-0.5	-0.2	-0.1	-0.1	-0.0	-0.1	-0.5	0.4	-0.2	-0.4	-0.3	-0.2	0.8	-0.3	-0.1	-0.3	-0.4	-0.1	-0.3
Hand grip strength (right)	0.1	0.2	0.4	-0.3	-0.3	-0.4	-0.4	-0.6	0.2	0.0	0.3	-0.6	-0.5	-0.5	-0.4	0.1	-0.5	-0.4	-0.5	-0.5	0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	3.3	-0.3	-0.1	0.5	-0.1	0.3	-0.2	0.8	1.8	0.4	-0.3	-0.2	-0.1	-0.8	-0.2	-0.0	-0.1	-0.0	-0.3	-0.1
High blood pressure (mother)	0.1	0.2	0.4	-0.1	-0.4	-0.6	-0.5	-0.5	-0.6	0.5	-0.1	0.1	-0.3	-0.5	-0.4	0.0	-0.4	-0.5	-0.5	-0.6	-0.4	-0.4
Trunk fat mass	0.1	0.3	1.3	1.1	0.5	0.7	0.4	0.8	-0.2	0.2	0.9	-0.3	0.3	0.4	0.4	0.7	0.4	0.5	0.4	0.3	-0.6	0.4
Number of incorrect matches in round	0.1	0.1	0.6	-0.2	0.2	0.6	0.3	0.2	-0.2	-0.0	0.4	-0.2	-0.1	-0.0	0.3	0.8	0.2	0.4	0.2	0.2	-0.4	0.2
Alcohol usually taken with meals	0.1	0.2	1.8	-0.8	-0.3	-0.1	-0.3	-0.2	0.1	0.1	-0.6	-1.3	-0.3	-0.2	-0.3	-0.4	-0.3	-0.3	-0.3	-0.4	-0.1	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	1.3	0.5	-0.1	-0.3	-0.1	-0.2	-0.1	0.2	0.9	0.2	0.1	0.1	0.0	-1.1	-0.0	-0.2	-0.1	-0.4	0.2	-0.0
Medication: Lansoprazole	0.1	0.2	1.0	0.1	0.2	0.4	0.3	0.3	-0.2	0.3	-0.6	-0.1	0.1	0.1	0.3	1.0	0.1	0.3	0.1	0.2	-1.0	0.2
Illnesses of mother	0.1	0.2	0.9	0.4	0.3	0.0	0.1	0.0	0.8	1.0	0.6	-0.4	0.3	0.4	0.1	0.5	0.3	0.1	0.2	0.1	0.2	0.3
Arm fat mass (right)	0.1	0.4	4.6	1.1	0.3	0.4	0.1	0.4	-0.4	0.1	2.1	-0.8	0.0	0.0	-0.0	0.8	0.0	0.1	0.0	-0.1	-0.5	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	2.0	-0.1	0.2	0.0	0.3	0.2	0.8	-0.2	0.8	0.5	0.3	0.2	0.3	-0.3	0.3	0.3	0.3	0.4	1.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	1.0	0.1	-0.3	-0.1	-0.4	-0.3	-0.3	0.5	0.1	-0.3	-0.1	-0.1	-0.3	0.7	-0.2	-0.4	-0.2	-0.4	-1.0	-0.2
Headache pain in last month	0.1	0.2	1.8	-0.4	-0.1	0.0	-0.1	-0.1	-0.4	-0.5	0.6	-0.3	-0.7	-0.6	0.0	0.5	-0.5	-0.0	-0.4	0.2	-1.4	-0.4
Glaucoma (self-reported)	0.1	0.2	0.8	0.4	0.2	0.0	0.3	0.5	0.1	-0.8	-0.1	0.2	0.2	0.2	0.3	0.9	0.4	0.3	0.4	0.2	-0.6	0.3
Gout (self-reported)	0.1	0.1	0.5	-0.5	-0.3	-0.2	-0.3	-0.3	-0.0	0.4	0.4	-0.5	-0.3	-0.2	-0.3	0.7	-0.4	-0.4	-0.4	-0.3	-0.4	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.9	-0.2	0.1	0.4	0.2	0.4	0.1	-0.1	-0.2	0.8	0.1	0.1	0.2	0.4	0.2	0.2	0.2	0.6	-0.9	0.2
Qualifications: College or University degree	0.1	0.2	1.3	-0.5	-0.1	-0.1	-0.2	-0.3	0.0	0.5	0.4	-0.7	-0.3	-0.2	-0.1	1.1	-0.2	-0.2	-0.2	-0.3	0.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.9	-0.5	-0.1	-0.0	-0.0	-0.0	-0.8	-0.9	-0.4	-0.4	-0.2	-0.2	0.0	-0.3	-0.2	0.0	-0.2	0.1	-0.6	-0.2
Medication: Allopurinol	0.1	0.2	1.1	-0.2	0.1	0.2	0.0	0.1	0.2	0.6	0.6	0.5	0.1	0.1	-0.0	1.1	0.1	0.0	0.1	0.2	-0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	-0.0	-0.2	-0.1	-0.2	-0.3	-0.2	0.1	0.5	-0.7	-0.2	-0.3	-0.2	-0.1	-0.2	-0.2	-0.2	-0.4	-0.4	-0.2
Whole body fat mass	0.1	0.5	2.0	1.2	0.7	0.8	0.5	0.9	-0.1	0.1	1.4	-0.1	0.4	0.5	0.4	1.0	0.4	0.5	0.4	0.4	-0.7	0.5
Leg fat mass (right)	0.1	0.4	2.3	1.2	0.6	0.6	0.4	0.8	-0.3	0.0	1.5	-0.1	0.3	0.3	0.4	0.8	0.3	0.4	0.3	0.3	-0.9	0.4
Knee pain experienced in last month	0.1	0.2	2.0	-0.5	-0.2	-0.3	-0.2	0.1	-0.7	-0.6	0.1	-0.7	-0.2	-0.2	-0.2	1.4	-0.2	-0.2	-0.2	-0.3	0.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.9	0.2	0.3	0.2	0.3	0.2	0.3	-0.0	0.2	0.9	0.3	0.3	0.4	-0.2	0.3	0.3	0.3	0.4	-0.9	0.3
Ever had bowel cancer screening	0.1	0.1	0.4	0.3	0.1	0.0	0.1	-0.1	-0.5	-0.1	0.0	-0.3	0.2	0.2	-0.0	0.7	0.2	0.0	0.2	0.3	0.3	0.2
Diabetes diagnosed by doctor	0.1	0.1	1.2	0.4	0.1	-0.1	0.2	0.1	0.2	-0.2	0.0	-0.1	0.3	0.3	-0.0	1.1	0.2	0.1	0.2	0.0	0.4	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.5	-0.5	-0.2	-0.3	-0.3	-0.1	-0.4	0.4	0.6	-0.5	-0.3	-0.3	-0.4	-0.7	-0.2	-0.2	-0.2	-0.6	0.3	-0.2
Smoking status: Current	0.1	0.2	1.0	0.8	0.4	0.3	0.3	0.4	0.1	1.0	0.2	0.2	0.3	0.3	0.2	-0.2	0.3	0.3	0.3	0.5	0.2	0.3
Arm fat mass (left)	0.1	0.4	4.2	1.1	0.4	0.4	0.1	0.5	-0.3	0.1	2.1	-0.8	0.1	0.1	0.0	1.1	0.1	0.1	0.1	0.0	-0.7	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.9	0.1	-0.0	-0.1	0.1	0.5	0.0	-0.9	-0.4	-0.1	-0.0	-0.0	0.1	0.2	0.2	0.1	0.1	0.5	-0.5	0.1
Unable to work because of sickness or disability	0.1	0.1	0.7	-0.3	0.0	0.1	0.0	0.0	-0.1	0.8	0.2	0.8	0.1	-0.0	-0.0	-0.7	0.1	0.0	0.1	0.2	-0.5	0.1
Leg fat mass (left)	0.1	0.6	2.6	1.5	0.8	0.8	0.6	0.9	-0.1	0.3	1.6	0.2	0.5	0.5	0.5	0.9	0.5	0.6	0.5	0.5	-0.7	0.6
Major Depression (MDD)	0.0	0.0	0.1	0.3	0.1	0.2	0.0	0.0	0.1	-0.3	0.0	-0.2	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.4	-0.7	-0.0	0.1	0.0	0.0	0.1	0.3	-0.3	0.2	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.3	-0.1	-0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.5	-0.2	-0.0	-0.0	0.1	-0.6	0.2	0.1	0.2	0.1	0.1	0.1
Blood Eosinophil Count	0.0	0.2	1.5	-0.0	-0.2	-0.1	-0.2	-0.3	-0.3	1.2	0.4	-0.8	-0.3	-0.3	-0.1	-0.9	-0.3	-0.2	-0.3	-0.0	-0.0	-0.3
Hair Pigment	0.0	1.2	17.0	-0.9	-0.1	0.2	-0.1	0.1	0.7	1.0	4.1	-0.4	-0.7	-0.7	-0.1	0.7	-0.4	-0.0	-0.4	-0.2	0.6	-0.4
Current tobacco smoking	0.0	0.1	0.3	0.5	-0.1	-0.2	-0.2	-0.1	-0.5	0.6	-0.2	0.0	-0.2	-0.2	-0.3	-0.3	-0.2	-0.2	-0.2	-0.0	-0.3	-0.2
Birth weight of first child	0.0	0.1	1.2	-0.1	-0.0	0.3	0.2	0.1	0.0	-0.1	-1.1	0.4	0.0	0.1	0.3	-0.2	0.0	0.2	0.0	0.1	-0.1	0.0

Hub : Genes

CD22

Models

Trait associations