Best TWAS P=1.64e-17 · Best GWAS P=4.03e-21 conditioned to 1.73e-31
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATP5O | 0.06 | 0.05 | lasso | 2 | 0.05 | 1.0e-06 | 7.8 | 8.0 | 1.1e-15 | -0.35 | 0.85 | 0.05 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ATP5O | 0.15 | 0.17 | lasso | 5 | 0.18 | 2.7e-13 | 7.6 | 6.2 | 5.2e-10 | -0.39 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Esophagus Mucosa | LINC00649 | 0.17 | 0.13 | enet | 10 | 0.16 | 7.2e-11 | 7.8 | -7.3 | 3.5e-13 | 0.19 | 0.90 | 0.10 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | LINC00649 | 0.14 | 0.01 | enet | 14 | 0.03 | 5.5e-03 | -3.9 | -5.9 | 4.8e-09 | -0.01 | 0.17 | 0.14 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | LINC00649 | 0.13 | 0.14 | enet | 9 | 0.09 | 5.3e-08 | 7.8 | -8.5 | 1.6e-17 | 0.32 | 0.36 | 0.64 | TRUE |
| 6 | GTEx | Uterus | TMEM50B | 0.45 | 0.28 | enet | 20 | 0.26 | 5.7e-06 | 4.6 | -5.6 | 1.6e-08 | -0.05 | 0.66 | 0.06 | FALSE |
| 7 | GTEx | Whole Blood | LINC00649 | 0.08 | 0.04 | lasso | 5 | 0.05 | 1.1e-05 | 5.2 | -5.7 | 1.3e-08 | 0.33 | 0.97 | 0.02 | TRUE |
| 8 | NTR | Blood | ITSN1 | 0.07 | 0.06 | lasso | 3 | 0.07 | 5.8e-21 | 7.8 | -7.6 | 2.6e-14 | -0.24 | 0.62 | 0.38 | FALSE |
| 9 | YFS | Blood | ITSN1 | 0.14 | 0.11 | bslmm | 527 | 0.12 | 5.8e-38 | 7.8 | -7.7 | 1.6e-14 | -0.25 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP5O | 0.04 | 0.01 | blup | 71 | 0.01 | 1.3e-03 | 7.8 | 5.3 | 1.1e-07 | -0.19 | 0.07 | 0.50 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATP5O | 0.08 | 0.10 | lasso | 4 | 0.11 | 6.1e-12 | -4.1 | 5.2 | 1.9e-07 | -0.53 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATP5O | 0.03 | 0.01 | blup | 71 | 0.01 | 3.4e-02 | 4.4 | 6.4 | 1.8e-10 | -0.38 | 0.09 | 0.48 | FALSE |