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chr21:34,115,455-36,040,382

Best TWAS P=1.64e-17 · Best GWAS P=4.03e-21 conditioned to 1.73e-31

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Skin Sun Exposed Lower leg	LINC00649	0.13	0.14	enet	9	0.09	5.3e-08	7.8	-8.5	1.6e-17	0.32	0.36	0.64	TRUE
9	YFS	Blood	ITSN1	0.14	0.11	bslmm	527	0.12	5.8e-38	7.8	-7.7	1.6e-14	-0.25	1.00	0.00	TRUE
2	GTEx	Cells Transformed fibroblasts	ATP5O	0.15	0.17	lasso	5	0.18	2.7e-13	7.6	6.2	5.2e-10	-0.39	1.00	0.00	TRUE
7	GTEx	Whole Blood	LINC00649	0.08	0.04	lasso	5	0.05	1.1e-05	5.2	-5.7	1.3e-08	0.33	0.97	0.02	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ATP5O	0.06	0.05	lasso	2	0.05	1.0e-06	7.8	8.0	1.1e-15	-0.35	0.85	0.05	FALSE
8	NTR	Blood	ITSN1	0.07	0.06	lasso	3	0.07	5.8e-21	7.8	-7.6	2.6e-14	-0.24	0.62	0.38	FALSE
3	GTEx	Esophagus Mucosa	LINC00649	0.17	0.13	enet	10	0.16	7.2e-11	7.8	-7.3	3.5e-13	0.19	0.90	0.10	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP5O	0.03	0.01	blup	71	0.01	3.4e-02	4.4	6.4	1.8e-10	-0.38	0.09	0.48	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	LINC00649	0.14	0.01	enet	14	0.03	5.5e-03	-3.9	-5.9	4.8e-09	-0.01	0.17	0.14	FALSE
6	GTEx	Uterus	TMEM50B	0.45	0.28	enet	20	0.26	5.7e-06	4.6	-5.6	1.6e-08	-0.05	0.66	0.06	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP5O	0.04	0.01	blup	71	0.01	1.3e-03	7.8	5.3	1.1e-07	-0.19	0.07	0.50	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP5O	0.08	0.10	lasso	4	0.11	6.1e-12	-4.1	5.2	1.9e-07	-0.53	1.00	0.00	FALSE