Best TWAS P=5.86e-52 · Best GWAS P=4.46e-42 conditioned to 0.667
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FBXO7 | 0.11 | 0.06 | lasso | 3 | 0.06 | 4.6e-08 | 2.3 | 8.2 | 2.2e-16 | -0.62 | 0.09 | 0.91 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | FBXO7 | 0.13 | 0.04 | enet | 16 | 0.07 | 2.3e-06 | -13.6 | 13.4 | 6.6e-41 | -0.81 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Hippocampus | FBXO7 | 0.36 | 0.09 | lasso | 7 | 0.12 | 9.4e-04 | -13.6 | 11.1 | 8.0e-29 | -0.86 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Esophagus Mucosa | FBXO7 | 0.29 | 0.07 | lasso | 6 | 0.11 | 7.4e-08 | 12.9 | 10.4 | 3.4e-25 | -0.57 | 0.93 | 0.07 | FALSE |
| 5 | GTEx | Lung | FBXO7 | 0.14 | 0.01 | lasso | 6 | 0.00 | 3.6e-01 | 2.3 | 10.0 | 1.8e-23 | -0.66 | 0.03 | 0.84 | FALSE |
| 6 | GTEx | Nerve Tibial | FBXO7 | 0.37 | 0.35 | lasso | 2 | 0.33 | 6.0e-24 | -13.6 | 13.6 | 2.2e-42 | -1.00 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | FBXO7 | 0.35 | 0.22 | lasso | 8 | 0.24 | 4.4e-13 | 13.0 | 12.6 | 2.4e-36 | -0.62 | 0.92 | 0.08 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | FBXO7 | 0.27 | 0.19 | enet | 15 | 0.20 | 2.6e-16 | 12.9 | 13.6 | 3.5e-42 | -0.73 | 0.92 | 0.08 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FBXO7 | 0.12 | 0.06 | lasso | 1 | 0.06 | 6.4e-07 | 12.5 | -12.5 | 6.5e-36 | 0.38 | 0.91 | 0.01 | TRUE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FBXO7 | 0.25 | 0.09 | enet | 15 | 0.20 | 2.2e-22 | -13.6 | 11.2 | 3.0e-29 | -0.79 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | FBXO7 | 0.05 | 0.03 | lasso | 5 | 0.03 | 2.5e-04 | -13.6 | -15.2 | 5.9e-52 | 0.95 | 0.01 | 0.98 | TRUE |