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chr22:27,675,538-31,118,395

Best TWAS P=2.16e-10 · Best GWAS P=1.38e-12 conditioned to 0.00892

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Cells Transformed fibroblasts	CCDC117	0.10	0.01	lasso	6	0.02	2.4e-02	-5.33	6.3	2.2e-10	-0.74	0.01	0.94	TRUE
2	CommonMind	Brain Pre-frontal Cortex	MTMR3	0.07	0.03	blup	473	0.06	5.3e-08	-3.65	-5.9	3.6e-09	-0.02	0.15	0.84	TRUE
8	YFS	Blood	CCDC117	0.03	0.02	lasso	3	0.02	3.1e-08	-4.62	5.9	3.8e-09	-0.16	0.86	0.01	TRUE
7	NTR	Blood	ASCC2	0.04	0.00	blup	390	0.01	4.5e-05	-0.84	5.7	1.1e-08	-0.03	0.12	0.02	TRUE
9	The Cancer Genome Atlas	Esophageal Carcinoma	OSM	0.51	0.10	enet	22	0.27	4.4e-09	5.90	5.5	4.4e-08	0.09	0.01	0.86	TRUE
10	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC117	0.03	0.01	blup	41	0.01	2.3e-02	-3.61	6.2	5.3e-10	-0.80	0.01	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC117	0.03	0.01	blup	323	0.02	2.3e-03	-5.01	5.9	3.1e-09	-0.76	0.11	0.49	FALSE
6	GTEx	Skin Sun Exposed Lower leg	CCDC117	0.07	0.03	enet	11	0.03	2.8e-03	-5.31	5.6	2.2e-08	-0.70	0.02	0.91	FALSE
11	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RNF215	0.16	0.08	lasso	3	0.10	8.6e-05	4.81	-5.5	2.9e-08	0.01	0.00	0.89	FALSE
5	GTEx	Nerve Tibial	TTC28	0.13	0.03	lasso	3	0.06	2.5e-05	4.28	-5.3	1.3e-07	0.42	0.29	0.53	FALSE
3	GTEx	Adipose Visceral Omentum	CHEK2	0.14	0.03	enet	13	0.03	9.1e-03	2.75	-5.2	1.5e-07	0.53	0.09	0.27	FALSE
12	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XBP1	0.06	0.03	blup	35	0.06	1.6e-03	-5.86	5.2	2.5e-07	-0.82	0.01	0.82	FALSE