Best TWAS P=2.16e-10 · Best GWAS P=1.38e-12 conditioned to 0.00892
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC117 | 0.03 | 0.01 | blup | 323 | 0.02 | 2.3e-03 | -5.01 | 5.9 | 3.1e-09 | -0.76 | 0.11 | 0.49 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | MTMR3 | 0.07 | 0.03 | blup | 473 | 0.06 | 5.3e-08 | -3.65 | -5.9 | 3.6e-09 | -0.02 | 0.15 | 0.84 | TRUE |
3 | GTEx | Adipose Visceral Omentum | CHEK2 | 0.14 | 0.03 | enet | 13 | 0.03 | 9.1e-03 | 2.75 | -5.2 | 1.5e-07 | 0.53 | 0.09 | 0.27 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | CCDC117 | 0.10 | 0.01 | lasso | 6 | 0.02 | 2.4e-02 | -5.33 | 6.3 | 2.2e-10 | -0.74 | 0.01 | 0.94 | TRUE |
5 | GTEx | Nerve Tibial | TTC28 | 0.13 | 0.03 | lasso | 3 | 0.06 | 2.5e-05 | 4.28 | -5.3 | 1.3e-07 | 0.42 | 0.29 | 0.53 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | CCDC117 | 0.07 | 0.03 | enet | 11 | 0.03 | 2.8e-03 | -5.31 | 5.6 | 2.2e-08 | -0.70 | 0.02 | 0.91 | FALSE |
7 | NTR | Blood | ASCC2 | 0.04 | 0.00 | blup | 390 | 0.01 | 4.5e-05 | -0.84 | 5.7 | 1.1e-08 | -0.03 | 0.12 | 0.02 | TRUE |
8 | YFS | Blood | CCDC117 | 0.03 | 0.02 | lasso | 3 | 0.02 | 3.1e-08 | -4.62 | 5.9 | 3.8e-09 | -0.16 | 0.86 | 0.01 | TRUE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | OSM | 0.51 | 0.10 | enet | 22 | 0.27 | 4.4e-09 | 5.90 | 5.5 | 4.4e-08 | 0.09 | 0.01 | 0.86 | TRUE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC117 | 0.03 | 0.01 | blup | 41 | 0.01 | 2.3e-02 | -3.61 | 6.2 | 5.3e-10 | -0.80 | 0.01 | 0.82 | FALSE |
11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RNF215 | 0.16 | 0.08 | lasso | 3 | 0.10 | 8.6e-05 | 4.81 | -5.5 | 2.9e-08 | 0.01 | 0.00 | 0.89 | FALSE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | XBP1 | 0.06 | 0.03 | blup | 35 | 0.06 | 1.6e-03 | -5.86 | 5.2 | 2.5e-07 | -0.82 | 0.01 | 0.82 | FALSE |