Hub : Genes

FBXO7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1110	0.0350	1.1e-03	0.061	0.012	0.039	0.047	0.062	5.7e-08	1.0e-02	1.4e-05	2.1e-06	4.6e-08
2	GTEx	Adipose Subcutaneous	0.1260	0.0480	6.3e-03	0.045	NA	0.070	NA	0.063	1.4e-04	NA	2.3e-06	NA	7.4e-06
3	GTEx	Brain Hippocampus	0.3645	0.1017	9.0e-04	0.089	NA	0.111	NA	0.121	4.3e-03	NA	1.5e-03	NA	9.4e-04
4	GTEx	Esophagus Mucosa	0.2900	0.0590	7.8e-07	0.070	NA	0.090	NA	0.111	2.0e-05	NA	1.3e-06	NA	7.4e-08
5	GTEx	Lung	0.1353	0.0492	6.4e-03	0.011	NA	-0.003	NA	-0.001	4.2e-02	NA	6.5e-01	NA	3.6e-01
6	GTEx	Nerve Tibial	0.3654	0.0518	1.7e-12	0.349	NA	0.311	NA	0.329	1.2e-25	NA	1.9e-22	NA	6.0e-24
7	GTEx	Skin Not Sun Exposed Suprapubic	0.3480	0.0700	6.8e-06	0.221	NA	0.166	NA	0.235	2.5e-12	NA	2.1e-09	NA	4.4e-13
8	GTEx	Skin Sun Exposed Lower leg	0.2690	0.0500	9.1e-09	0.189	NA	0.199	NA	0.185	1.7e-15	NA	2.6e-16	NA	3.1e-15
9	YFS	Blood	0.0749	0.0190	1.4e-07	0.036	0.024	0.041	0.034	0.044	4.6e-12	1.7e-08	1.9e-13	3.0e-11	2.2e-14
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.1184	0.0520	2.6e-04	0.064	0.032	0.025	NA	0.056	9.5e-08	1.5e-04	7.7e-04	NA	6.4e-07
11	TCGA	Brain Lower Grade Glioma	0.2501	0.0524	0.0e+00	0.089	0.195	0.201	NA	0.191	2.4e-10	1.0e-21	2.2e-22	NA	3.1e-21
12	TCGA	Prostate Adenocarcinoma	0.1316	0.0460	4.2e-04	0.023	0.029	0.011	NA	0.022	1.6e-03	4.8e-04	2.2e-02	NA	1.9e-03
13	TCGA	Thyroid Carcinoma	0.0490	0.0220	9.9e-04	0.028	0.022	0.020	NA	0.034	8.9e-04	3.2e-03	4.5e-03	NA	2.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.3	0.5	1.6	0.8	-0.0	1.3	0.5	0.8	0.9	0.6	0.8	-0.0	0.2	0.7	1.0	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	5.7	1.1	-1.0	0.8	-0.3	0.5	0.3	-0.4	-0.3	1.1	1.9	0.2	2.4	0.3
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-0.7	-0.2	-1.4	-0.1	-0.8	-1.1	-0.4	-0.6	-0.5	1.0	-0.8	0.5	0.9
Depression (Nagel 2018)	0.3	0.4	1.3	-0.2	-0.4	-0.5	-0.8	-0.6	-0.5	-0.2	-0.4	0.9	-1.0	-0.4	-1.1	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	-0.6	-0.5	1.2	-0.4	-1.0	0.7	-0.6	-0.1	0.4	-0.2	-0.2	-0.6	-0.3
Neuroticism (Nagel 2018)	0.6	1.3	3.9	-0.5	-0.8	-1.6	-1.0	-0.9	-2.0	-0.9	-1.2	0.3	1.0	-1.1	0.7	1.8
Schizophrenia (2018)	0.7	1.4	5.0	0.7	-1.3	-0.0	-0.8	0.0	-0.4	-1.0	-1.0	1.5	2.2	-0.2	2.2	0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.5	0.7	-0.1	0.6	-0.4	0.6	0.3	0.4	0.2	-0.6	-0.1	0.1	-0.8
Worry (Nagel 2018)	0.3	0.6	1.3	-0.2	-0.5	0.0	-1.1	-0.8	-0.5	-1.0	-0.9	1.2	0.6	-0.7	0.5	0.8
Alzheimer’s Disease (in mother)	1.0	1.1	4.3	1.0	1.0	0.0	-0.5	0.9	1.2	0.1	0.1	1.7	-0.7	1.3	-2.1	-0.9
Alzheimer’s Disease (in father)	0.5	0.5	1.4	1.2	-0.5	-1.0	-0.1	0.8	-0.6	-0.0	-0.6	0.3	1.1	0.3	1.1	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	1.3	0.1	-0.9	-0.8	0.7	-0.0	-0.3	-0.6	1.5	-0.1	0.6	-1.5	0.2
Crohns Disease (2017)	0.8	1.7	3.6	-0.1	0.5	1.1	1.3	0.7	1.4	1.4	1.8	-1.5	-1.9	0.8	-1.4	-1.7
Irritable Bowel Disease (IBD)	1.2	2.9	6.5	0.8	1.0	1.5	1.8	1.5	1.3	2.2	2.4	-1.3	-2.5	1.2	-1.4	-2.0
Ulcerative Colitis (UC)	1.3	2.5	4.5	1.8	1.2	1.8	1.5	2.0	1.2	2.0	2.1	-0.0	-1.8	1.4	-0.3	-1.7
Major Depression (MDD)	0.2	0.3	0.8	0.1	-0.3	-0.9	-0.4	-0.1	-0.1	-0.6	-0.5	0.9	0.5	-0.4	0.7	0.3
Reaction Time	2.4	4.6	8.0	2.1	2.3	1.7	2.0	2.4	1.7	2.8	2.7	-0.5	-2.7	2.0	-1.0	-2.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	-0.8	-0.2	0.6	0.3	-0.8	0.4	0.0	0.4	-0.4	-0.6	-0.1	-0.8	-0.4
Breast Cancer	0.2	0.4	1.2	-0.7	1.1	-0.9	1.1	0.2	-0.0	0.4	0.4	-0.5	0.1	0.1	1.0	-0.1
Ovarian Cancer	0.8	1.1	3.1	-1.2	-1.1	-0.1	-1.4	-1.3	-0.3	-1.3	-1.1	0.1	-0.5	-1.2	-1.7	0.5
Prostate Cancer	0.9	1.2	6.2	0.4	-0.5	0.7	-1.8	-0.4	0.3	-1.4	-1.4	2.5	1.1	-0.3	-0.2	0.4
Age at First Birth	1.3	1.9	3.0	-1.7	-1.2	-1.0	-1.4	-1.5	-1.4	-1.3	-1.2	-0.9	-0.7	-1.7	-1.7	1.4
Bipolar Disorder (2011)	0.5	0.5	2.3	0.4	-0.7	0.6	0.3	0.1	-0.1	0.2	0.1	-0.7	1.5	0.3	1.3	0.3
Body Mass Index (BMI) (2010)	0.8	1.0	2.7	0.2	1.6	1.0	1.2	0.5	0.6	1.4	1.4	-0.3	-1.3	0.8	-0.3	-1.0
Coronary Artery Disease (CAD)	1.0	1.2	4.3	2.1	0.9	0.1	0.6	1.9	1.3	0.4	0.5	0.6	0.5	1.4	1.2	-0.8
Crohns Disease (2012)	0.6	0.9	3.6	-0.3	0.2	1.0	0.2	-0.0	0.9	0.7	0.9	-0.9	-1.9	0.3	-1.6	-1.1
Mean Putamen Volume	0.4	0.5	1.2	-0.9	-0.7	-0.7	-0.3	-0.8	-0.7	-0.5	-0.4	0.2	0.9	-0.3	1.1	0.7
Fasting Glucose	4.1	4.9	8.9	1.9	2.7	1.8	2.1	2.3	2.0	2.6	3.0	-0.1	-2.8	2.1	0.6	-2.7
HbA1C	4.3	4.8	7.1	2.1	2.7	1.9	2.0	2.5	2.6	2.5	2.5	1.0	-1.7	2.5	0.4	-2.7
HDL Cholesterol	0.2	0.4	1.0	-0.6	-0.3	-0.6	-1.0	-0.1	-0.3	-0.5	-0.6	0.1	-0.9	-0.3	-1.0	0.4
LDL Cholesterol	0.3	0.5	1.8	0.7	-0.1	0.1	-0.1	0.5	1.1	-0.2	-0.0	1.3	1.0	0.9	0.6	-0.4
Lupus	0.9	1.3	4.7	-0.4	-1.3	-0.8	-0.7	-0.6	-1.0	-1.2	-1.2	0.4	2.2	-1.0	1.7	1.3
Neuroticism (2016)	0.4	0.6	1.9	1.0	-0.3	-1.4	-1.3	0.6	-0.8	-0.3	-0.6	0.8	0.8	-0.1	0.1	0.8
Primary Biliary Cirrhosis	0.2	0.3	1.2	0.8	0.3	-0.2	-0.2	0.4	-0.3	0.4	0.2	1.1	-0.9	0.2	-0.3	0.0
Rheumatoid Arthritis	2.8	3.9	9.1	-1.7	-2.5	-0.7	-3.0	-2.3	-0.8	-2.7	-2.3	1.6	-0.3	-2.5	-1.7	1.4
Schizophrenia (2014)	0.6	1.4	4.2	0.5	-1.3	0.5	-1.3	-0.2	-0.0	-1.2	-1.3	1.6	2.1	-0.3	1.9	0.7
Triglycerides	0.1	0.2	0.4	0.6	0.6	-0.1	0.2	0.5	-0.0	0.6	0.2	0.3	0.1	0.3	0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	0.8	0.5	0.4	-0.1	0.9	0.9	0.3	0.1	1.1	-0.1	1.0	-0.2	-0.5
Ulcerative Colitis	0.9	1.2	2.6	1.6	0.9	1.2	1.0	1.6	0.6	1.5	1.4	-0.1	-0.6	1.3	-0.3	-0.9
Blood Eosinophil Count	0.0	0.3	1.5	0.5	-0.3	-0.4	-0.7	0.3	-0.2	-0.1	-0.2	1.2	0.2	-0.0	0.9	0.4
Blood Platelet Count	0.1	1.0	4.0	0.5	1.0	-0.2	0.5	0.8	0.7	1.1	1.2	0.1	-2.0	0.3	-1.4	-1.1
Blood Red Count	13.0	125.5	231.0	8.2	13.4	11.1	10.4	10.0	13.6	12.6	13.6	1.6	-12.5	11.2	-3.0	-15.2
Blood White Count	0.1	0.4	1.5	0.8	0.2	1.2	0.1	0.6	0.6	0.2	0.1	1.2	-0.3	0.7	-0.2	-0.5
Heel T-Score	0.1	0.5	1.4	0.9	0.9	0.6	0.5	1.2	0.3	0.5	0.1	0.8	0.1	1.1	0.7	-0.2
BMI	1.2	7.0	12.8	2.7	3.3	1.3	2.9	3.3	2.3	3.6	3.4	-0.7	-2.3	2.8	0.4	-3.0
Height	0.2	2.9	6.9	-1.1	-0.2	-2.6	-2.3	-1.7	-0.9	-2.6	-2.3	1.4	1.2	-1.7	-0.0	1.7
Waist Hip Ratio (WHR)	0.4	2.0	5.5	0.1	-1.0	-2.3	-1.3	-0.4	-2.1	-1.1	-1.8	0.5	1.6	-0.4	1.1	2.1
Systolic Blood Pressure	0.2	0.8	2.1	-1.2	0.4	-0.0	-1.4	-1.4	0.5	-0.7	-0.6	1.1	-1.0	-0.4	-1.4	-0.3
Smoking Status	0.3	0.8	2.2	0.7	0.5	-0.1	1.3	0.8	-0.1	1.5	1.4	-0.8	-1.0	0.8	0.4	-0.6
Allergy or Eczema	1.7	4.5	9.6	-0.7	-2.3	-1.4	-2.1	-1.6	-2.5	-2.5	-2.7	0.3	3.1	-1.9	1.6	3.0
Cardiovascular Disease	0.3	1.1	3.6	1.9	0.6	-0.2	0.4	1.5	0.8	1.3	1.0	0.6	-0.2	1.4	1.3	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.9	0.1	0.3	0.1	0.6	0.1	0.1	0.3	0.3	-0.3	1.0	0.3	0.6	-0.1
Respiratory disease	0.3	0.6	1.8	-0.8	-0.4	-0.4	-0.2	-0.6	-1.3	0.1	-0.1	-1.3	-1.1	-1.0	-0.2	0.7
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.9	0.9	1.9	1.1	1.1	1.4	1.7	1.7	1.5	0.6	-1.9	1.4	-1.2	-2.0
Lung FEV1/FVC ratio	0.3	1.6	6.2	1.2	-0.6	-2.5	-1.1	0.8	-0.2	-1.1	-1.0	1.8	1.8	0.0	1.2	0.7
Lung FVC	0.3	1.4	4.8	1.0	0.5	2.2	-0.2	1.1	1.3	0.4	0.7	1.1	-1.4	0.5	-1.9	-1.2
Neuroticism	0.7	1.6	4.1	-0.3	-0.8	-1.8	-0.4	-0.7	-1.9	-0.7	-0.9	-0.5	2.0	-0.7	1.7	1.8
Chronotype (morning person)	0.1	0.1	0.4	0.0	-0.6	0.1	-0.5	0.1	-0.3	-0.2	-0.3	-0.4	-0.3	-0.3	-0.5	0.3
Hair Pigment	0.0	1.3	7.2	-1.4	-0.3	-2.7	0.8	-1.1	-1.1	0.5	0.2	-1.5	-0.7	-0.7	-0.9	0.4
Tanning	0.1	0.9	3.1	0.9	-1.0	-0.4	-1.3	0.8	0.3	-0.2	-0.5	1.8	-0.9	0.0	-1.7	-0.1
Hand grip strength (left)	0.4	1.2	4.2	-0.1	-0.6	-2.1	-1.7	-0.4	-1.0	-0.8	-0.9	0.7	-1.3	-1.0	-1.2	0.9
Number of treatments/medications taken	0.1	0.2	1.7	-0.4	1.3	-0.6	0.1	-0.1	-0.1	0.2	0.1	-0.5	0.2	0.3	0.2	0.0
Average weekly spirits intake	0.4	0.5	1.6	1.3	0.8	0.3	0.1	0.9	0.7	0.5	0.6	0.8	-0.7	0.9	-0.1	-0.7
Sensitivity / hurt feelings	0.4	0.8	2.6	1.2	0.2	-0.8	0.1	0.4	-1.4	-0.2	-0.4	-0.1	1.1	-0.2	1.6	1.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.9	-0.4	-1.2	-1.0	-1.7	-1.2	-1.4	-1.2	-1.4	0.7	-0.1	-1.1	-0.8	1.4
Hearing difficulty/problems: Yes	0.4	0.6	3.2	0.8	-0.1	-0.2	1.0	1.3	0.1	0.7	0.7	-1.8	0.3	0.4	0.0	-0.2
Relative age of first facial hair	0.4	0.8	1.5	1.0	0.6	-0.3	1.1	1.1	0.7	1.1	1.2	0.0	0.4	1.2	0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.1	0.8	0.8	0.8	-0.3	0.4	0.8	-0.4	-0.6	1.4	1.8	1.1	1.3	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	-1.2	0.2	-0.3	-0.6	-1.0	-0.7	-0.3	-0.3	-0.4	-0.3	-0.5	-1.3	0.6
Ever had hysterectomy (womb removed)	1.2	1.4	8.3	-1.0	-0.0	-0.1	-1.1	-0.8	-0.4	-0.2	-0.1	-0.5	-2.9	-1.0	-2.3	0.0
Systolic blood pressure, automated reading	0.3	0.7	1.7	-0.4	-0.1	-0.7	-1.2	-1.2	-0.4	-1.1	-1.3	0.9	1.1	-0.3	0.6	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.7	-0.0	0.3	-0.2	-0.5	-0.2	0.3	-0.7	-0.8	1.3	0.5	0.2	-0.5	0.1
Angina	0.9	1.2	2.7	-0.1	1.5	1.6	1.6	0.1	1.5	0.8	1.2	-0.2	-0.7	0.7	-0.2	-1.4
Medication for hormone replacement therapy	0.5	0.6	5.8	-0.8	0.1	-0.3	-0.2	-0.4	-0.3	-0.0	-0.1	-0.9	-0.4	-0.2	-2.4	0.1
Vitamin and mineral supplements	2.7	3.7	8.0	0.9	2.3	1.5	2.4	1.1	2.5	2.1	2.6	-0.2	-2.1	1.6	-0.3	-2.8
Supplements: Zinc	0.2	0.3	1.4	1.0	-0.2	-0.3	0.3	0.6	-0.0	0.1	-0.0	0.4	0.6	0.2	1.2	0.1
Medication: Co-codamol	0.2	0.2	0.6	0.1	0.6	-0.5	0.8	0.5	-0.2	0.7	0.4	-0.5	-0.1	0.3	-0.5	-0.0
Medication: Metformin	0.7	1.0	2.1	0.3	1.2	1.4	0.8	0.6	1.2	0.9	0.8	0.8	-0.9	0.9	-1.2	-1.3
Diabetes (father)	0.2	0.2	0.7	-0.5	-0.7	-0.1	-0.4	-0.6	0.1	-0.8	-0.5	0.2	0.1	-0.5	0.1	0.2
Diabetes (mother)	1.3	1.7	8.3	0.1	0.3	0.0	-1.7	-0.1	1.2	-1.8	-1.5	2.9	1.8	0.1	0.1	-0.0
Severe depression (siblings)	1.5	1.6	4.2	0.7	2.0	1.9	0.5	0.9	1.3	1.4	1.3	-0.2	-1.8	0.9	-0.7	-1.5
Pack years adult smoking proportion	0.2	0.3	1.1	1.1	0.7	-0.3	0.2	0.8	-0.2	0.5	0.2	0.5	-0.3	0.7	0.0	-0.0
Impedance of leg (right)	1.9	9.0	16.0	-1.4	-3.0	-3.6	-3.2	-2.3	-3.3	-3.6	-3.8	-0.1	4.0	-2.6	1.5	4.0
Leg fat-free mass (left)	0.9	4.7	11.2	1.4	2.9	1.6	1.9	1.9	2.2	2.5	2.5	0.4	-3.4	1.7	-1.3	-2.7
Trunk fat percentage	0.5	2.1	4.1	1.6	1.9	0.2	1.5	2.0	1.1	2.0	1.6	-0.5	-0.3	1.9	0.4	-1.5
Hand grip strength (right)	0.5	1.5	3.8	0.1	-1.4	-1.7	-1.9	-0.2	-1.0	-1.1	-1.2	0.8	-1.5	-1.3	-1.1	1.1
Townsend deprivation index at recruitment	0.6	0.8	1.8	1.3	1.2	0.7	0.7	1.3	0.5	1.1	1.0	-0.2	-0.3	1.3	0.4	-0.7
Current tobacco smoking	0.2	0.3	1.7	1.0	-0.6	0.3	-0.5	0.4	-0.0	-0.2	-0.1	1.3	-0.4	0.5	0.1	0.2
Average weekly fortified wine intake	0.2	0.3	1.6	0.6	0.8	-0.1	0.2	0.2	-0.2	0.0	0.1	-0.7	0.4	-0.3	1.3	0.2
Maternal smoking around birth	0.2	0.2	0.8	0.6	0.1	0.3	-0.1	0.5	0.9	-0.3	-0.2	0.5	-0.7	0.2	-0.4	-0.5
Fed-up feelings	0.9	1.7	4.2	-0.5	-1.3	-2.1	-0.6	-1.0	-2.0	-1.0	-1.1	-1.0	1.1	-1.5	1.1	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	1.1	-0.3	-0.2	-0.3	0.5	-0.3	0.6	0.4	0.8	-1.0	0.3	-0.9	-0.1
Relative age voice broke	0.6	0.9	2.2	0.8	0.5	-0.4	1.1	1.0	0.1	1.5	1.4	-1.4	-0.3	1.1	0.3	-0.6
Taking other prescription medications	0.3	0.4	2.2	-1.0	1.5	-0.3	-0.2	-0.6	0.7	-0.3	-0.3	0.5	0.6	0.3	-0.2	-0.4
Age when periods started (menarche)	0.6	1.4	2.6	-0.8	-1.3	-0.4	-1.5	-1.3	-1.1	-1.6	-1.6	0.9	1.0	-0.9	0.9	1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.1	-0.3	0.7	0.9	-0.1	-0.3	1.1	0.1	0.2	0.9	-1.1	0.3	-1.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.2	-0.8	0.3	0.1	-0.7	-0.5	0.1	-0.3	-0.4	0.6	-1.2	-0.5	-1.5	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.7	0.4	0.2	1.0	-0.6	0.4	0.7	0.1	-0.1	1.3	-0.3	0.5	-0.8	-0.6
Qualifications: CSEs or equivalent	0.4	0.6	1.7	0.3	-1.3	0.0	-1.2	-0.2	-0.8	-0.9	-1.0	0.8	0.4	-0.6	0.2	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-1.3	-0.4	1.2	-0.8	-1.0	0.0	-0.8	-0.7	0.1	0.2	-1.0	-1.2	0.3
High blood pressure	0.1	0.2	0.8	0.9	0.2	0.1	-0.3	0.3	0.4	0.3	0.0	0.4	0.1	0.5	0.5	-0.3
Hayfever, allergic rhinitis or eczema	3.4	7.4	14.2	-1.3	-3.1	-2.3	-2.6	-2.1	-3.3	-3.1	-3.4	0.1	3.6	-2.6	1.5	3.8
Multivitamins +/- minerals	2.0	2.6	5.6	-0.8	-2.4	-1.6	-1.8	-1.0	-2.0	-1.8	-1.9	-0.5	1.0	-1.7	-0.1	2.2
Stomach or abdominal pain in last month	2.2	2.8	6.0	-0.3	-1.9	-1.5	-2.1	-1.0	-1.8	-2.2	-2.4	-0.0	1.9	-1.4	0.7	2.3
Supplements: Glucosamine	0.4	0.5	2.3	0.6	0.1	0.6	-1.0	0.3	0.5	-0.6	-0.8	1.5	0.7	0.5	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.8	0.5	1.2	-0.3	0.7	1.2	0.5	1.2	1.1	-0.2	-1.9	1.0	-1.3	-0.9
Medication: Atenolol	0.2	0.2	1.0	-0.0	-0.2	-1.0	0.5	0.4	0.1	0.4	0.1	0.1	0.6	0.6	0.4	-0.1
Medication: Levothyroxine sodium	0.6	1.0	2.3	0.5	0.9	1.1	1.5	0.6	0.7	1.3	1.3	-1.1	-0.0	1.1	0.6	-1.0
Sitting height	0.1	0.4	2.3	0.1	0.6	-0.1	-0.1	0.0	0.2	0.1	0.1	1.0	-1.5	-0.2	-1.1	-0.3
Chronic bronchitis/emphysema (father)	0.5	0.5	3.4	-0.3	-0.4	0.2	0.9	-0.1	-0.4	0.1	0.3	-1.8	0.9	-0.5	1.1	0.3
High blood pressure (mother)	0.2	0.2	1.0	0.7	-0.3	0.1	-0.5	-0.0	-0.6	-0.2	-0.2	-0.5	0.3	-0.2	1.0	0.4
Body mass index (BMI)	1.2	4.9	9.5	2.1	3.0	1.4	2.5	2.6	1.8	3.1	2.8	-0.6	-1.7	2.4	0.4	-2.5
Impedance of leg (left)	1.4	6.7	13.1	-1.1	-2.4	-3.0	-2.8	-1.8	-3.1	-3.0	-3.3	-0.2	3.6	-2.0	1.1	3.6
Leg predicted mass (left)	0.9	4.7	11.1	1.4	2.9	1.6	1.9	1.9	2.3	2.5	2.5	0.5	-3.3	1.7	-1.2	-2.8
Trunk fat mass	0.7	2.8	5.7	1.9	2.4	0.3	1.7	2.3	1.2	2.3	1.9	-0.3	-0.9	2.0	0.3	-1.7
Waist circumference	0.6	2.2	4.8	1.6	2.2	0.5	1.4	1.8	1.0	2.2	1.7	-0.1	-1.3	1.9	0.4	-1.5
Number of incorrect matches in round	0.2	0.4	1.8	0.4	-0.3	-0.3	-0.6	-0.1	0.1	-0.8	-0.7	1.1	1.3	0.3	-0.1	0.4
Past tobacco smoking	0.1	0.2	0.7	-0.1	-0.1	0.4	-0.4	-0.4	0.1	-0.8	-0.8	0.7	0.6	-0.4	0.3	0.4
Alcohol usually taken with meals	0.4	0.7	2.6	1.5	0.2	-0.6	0.6	0.9	-0.2	0.3	0.1	0.7	1.2	0.7	1.6	0.3
Nervous feelings	0.1	0.2	0.6	0.6	0.1	0.4	-0.4	0.2	0.1	-0.5	-0.3	0.8	0.7	0.2	0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.9	0.6	0.1	0.1	-0.9	0.3	-0.0	-0.0	-0.2	1.4	-0.9	0.0	-0.8	0.0
Hearing difficulty/problems with background noise	1.5	2.4	4.6	-1.8	-1.4	-2.1	-1.3	-1.0	-2.1	-1.1	-1.5	-1.4	0.8	-1.7	-1.6	1.9
Hair/balding pattern: Pattern 2	0.7	0.8	2.5	0.3	0.8	0.7	1.6	1.1	0.3	1.3	1.2	-1.0	0.4	1.0	0.6	-0.6
Had menopause	1.1	1.4	3.4	-1.2	-0.3	-1.5	-0.3	-1.3	-1.2	-1.1	-1.0	-0.9	1.9	-1.2	0.8	1.4
Had other major operations	0.4	0.4	1.4	-1.1	-0.1	-1.2	-0.5	-0.5	-0.5	-0.6	-0.7	-0.1	-0.0	-0.8	-0.6	0.6
Forced vital capacity (FVC)	0.3	1.1	7.7	-0.6	-0.3	0.4	-1.2	-0.5	-0.5	-0.6	-0.6	0.5	-1.4	-1.0	-2.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.9	-0.6	0.1	0.8	0.1	-0.2	0.2	0.2	-0.0	0.1	-0.9	0.2	-0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	0.9	1.2	-0.2	0.8	0.7	0.1	0.7	0.8	-1.1	0.2	0.4	1.2	-0.3
Qualifications: None of the above	0.1	0.3	0.8	0.1	-0.2	-0.9	0.3	-0.1	-0.6	0.4	0.3	-0.9	-0.7	-0.2	-0.6	0.2
Financial difficulties in last 2 years	0.5	0.7	1.9	-1.0	-0.5	-1.4	-0.5	-0.9	-1.2	-0.7	-0.9	-0.5	-0.1	-1.0	-0.6	1.1
Mouth/teeth dental problems	0.9	1.4	3.3	1.6	1.3	1.8	0.6	1.4	1.1	1.0	1.2	0.4	-0.5	1.4	0.8	-1.1
Heart attack	0.7	0.9	4.7	-1.3	-0.1	-0.3	-0.2	-1.2	-0.2	-1.0	-1.0	0.3	2.2	-0.5	0.8	0.7
Allergy	0.9	2.1	5.2	0.5	1.7	1.0	1.5	0.9	2.3	1.2	1.6	0.4	-1.7	1.4	-0.9	-2.2
Pain all over the body in last month	2.7	2.9	5.2	2.2	2.1	1.1	1.7	2.3	1.4	2.1	1.8	0.7	-0.0	2.2	1.4	-1.6
Diabetes (self-reported)	0.8	1.3	3.1	0.1	1.7	0.9	1.2	0.6	1.4	1.2	1.0	0.4	-1.5	1.1	-0.8	-1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	4.4	0.5	-1.0	-0.1	-1.5	-0.3	-0.5	-1.5	-1.5	1.3	2.1	-0.5	1.2	1.2
Medication: Ramipril	0.2	0.2	1.6	-0.2	-0.2	0.3	-0.3	-0.3	0.5	0.0	0.1	0.2	-0.5	0.2	-1.3	-0.4
Medication: Simvastatin	0.2	0.3	1.3	0.1	0.6	-0.3	0.7	-0.0	0.7	-0.2	0.0	0.1	1.1	0.5	0.8	-0.4
Fluid intelligence score	0.1	0.1	0.6	-0.5	-0.5	0.4	-0.1	-0.5	-0.2	-0.2	-0.1	-0.1	-0.0	-0.3	-0.8	0.2
Illnesses of siblings	0.3	0.5	1.3	0.9	0.2	0.9	0.4	0.9	0.7	0.8	0.7	0.2	-0.0	1.2	-0.2	-0.6
Neuroticism score	1.0	2.1	5.3	0.0	-1.2	-1.5	-1.0	-0.8	-1.9	-1.4	-1.6	0.5	2.3	-1.0	1.9	2.1
Weight	0.8	3.9	9.8	1.9	3.1	0.7	2.0	2.4	1.5	2.6	2.4	-0.1	-2.0	2.0	-0.0	-2.1
Impedance of arm (right)	1.2	5.7	12.4	-1.9	-3.5	-2.5	-2.4	-2.2	-2.4	-2.7	-2.8	-0.3	2.7	-2.2	0.2	2.9
Arm fat percentage (right)	0.6	2.3	5.5	1.3	1.8	0.3	2.0	1.9	0.9	2.4	2.0	-1.1	-0.6	1.7	0.5	-1.5
Trunk fat-free mass	0.6	3.6	11.2	1.1	3.4	0.8	1.3	1.5	1.6	2.1	2.1	0.3	-3.2	1.2	-1.3	-2.1
Hip circumference	0.6	2.8	6.2	1.4	2.5	0.9	1.7	1.9	1.4	2.3	2.1	-0.2	-1.3	1.7	0.3	-1.9
Time employed in main current job	0.4	0.5	3.1	-0.8	0.7	0.5	0.0	-0.7	0.3	0.1	0.2	0.1	-1.1	-0.1	-1.8	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.6	0.2	0.3	-0.5	-0.5	-0.3	-0.1	-0.3	-0.0	0.1	-0.1	-0.2	0.2
Father’s age at death	3.8	5.1	11.1	-0.8	-2.7	-1.4	-3.1	-1.7	-1.5	-3.2	-3.3	1.5	2.8	-1.7	0.1	2.6
Worrier / anxious feelings	2.1	4.0	10.1	-0.5	-2.1	-2.1	-2.2	-1.4	-3.2	-1.9	-2.3	-0.0	1.7	-2.1	0.4	3.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.2	-0.7	-0.6	-0.3	-0.1	-0.9	0.0	-0.1	-0.2	-0.8	-0.5	-1.0	0.5
Falls in the last year	0.5	0.7	3.7	-1.1	-0.3	-0.3	-0.3	-0.9	-0.7	-0.2	-0.4	-1.2	-0.3	-0.5	-1.9	0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.9	0.1	0.8	-0.3	0.2	-0.0	-0.2	-0.0	0.1	-0.9	-0.5	-0.3	0.4	0.0
Number of live births	1.2	1.7	3.8	1.1	1.7	-0.2	1.9	1.5	0.8	1.7	1.8	-1.2	-0.1	1.3	1.2	-1.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	7.0	-0.2	0.2	-0.1	-0.9	0.0	-0.2	-0.3	-0.2	0.5	-1.4	-0.9	-2.7	0.1
Pulse rate	0.3	0.5	2.1	0.0	1.5	0.2	1.0	0.6	0.7	0.2	0.5	-0.5	0.4	0.3	1.2	-0.6
Happiness	0.3	0.4	1.4	0.3	0.7	0.7	0.1	-0.3	0.9	-0.7	-0.5	1.2	0.9	0.2	-0.3	-0.3
Noisy workplace	1.1	1.4	6.0	-0.1	-0.7	-1.7	1.0	0.2	-1.7	0.5	0.1	-2.4	1.3	-0.5	0.9	1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.8	-0.0	0.1	-0.8	-0.9	0.0	-0.5	-0.3	0.5	-1.1	-0.8	-1.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.3	-0.6	-0.1	0.1	0.3	-0.3	0.4	0.1	-0.4	0.1	0.3	0.2	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.4	0.0	0.0	0.5	-0.2	0.3	0.5	0.4	-0.8	-0.6	0.1	-0.4	-0.5
Asthma	0.4	0.8	2.8	0.3	0.8	1.7	0.4	0.6	0.7	1.2	1.2	-0.0	-1.3	0.7	0.6	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.6	-0.5	0.7	0.7	-0.0	-0.3	0.0	0.0	0.2	-0.3	-0.7	-0.3	0.1	-0.1
Medication: Cholesterol lowering	0.4	0.6	2.7	-0.8	1.6	-0.5	1.3	-0.1	0.8	0.5	0.8	-0.5	-0.1	0.2	-0.6	-0.9
Depression (self-reported)	0.7	0.9	3.2	-0.3	1.6	0.1	0.8	-0.3	1.2	0.4	0.7	0.5	-1.8	0.1	-1.1	-1.2
Medication: Lansoprazole	0.1	0.1	0.5	0.1	0.5	-0.5	0.0	-0.1	-0.3	0.0	-0.3	0.3	0.5	0.5	0.7	0.4
Prospective memory result	0.1	0.1	0.5	0.2	-0.4	-0.1	-0.3	-0.2	-0.3	0.3	0.0	-0.7	-0.5	-0.2	-0.0	0.1
Lung cancer (father)	0.9	1.0	2.5	-1.2	-1.6	-1.1	-0.9	-1.3	-1.4	-0.7	-0.9	0.3	0.0	-1.2	-0.1	1.2
Illnesses of mother	0.2	0.3	1.3	0.9	-0.6	0.4	-0.0	0.7	0.4	0.0	0.2	1.1	-0.3	0.2	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	3.5	0.5	0.2	0.2	-0.6	0.6	0.4	-0.0	0.1	0.9	-1.2	-0.1	-1.9	-0.4
Pulse wave Arterial Stiffness index	0.7	0.8	5.2	0.5	0.8	0.5	0.8	0.3	0.3	0.1	0.4	-0.9	1.2	0.6	2.3	-0.2
Impedance of arm (left)	0.7	3.3	8.8	-1.2	-3.0	-1.8	-1.7	-1.4	-1.7	-2.1	-2.1	-0.1	2.4	-1.5	0.7	2.1
Arm fat mass (right)	1.1	4.5	8.7	2.2	2.7	1.0	2.3	2.7	1.7	2.9	2.6	-0.4	-1.5	2.4	0.4	-2.3
Trunk predicted mass	0.6	3.4	11.0	1.2	3.3	0.7	1.3	1.5	1.6	2.0	2.1	0.4	-3.1	1.2	-1.2	-2.1
Standing height	0.1	0.8	2.6	-0.1	0.6	-1.6	-1.3	-0.4	-0.4	-0.8	-0.8	1.1	-0.7	-0.8	-0.9	0.6
Length of working week for main job	1.3	1.5	6.1	-1.6	-0.2	0.9	-1.2	-1.7	0.1	-0.9	-0.8	0.2	-1.4	-1.4	-2.5	-0.0
Exposure to tobacco smoke at home	1.2	1.4	2.8	-0.8	-1.6	-0.8	-0.8	-1.0	-1.6	-1.2	-1.5	-0.2	0.9	-1.4	0.3	1.7
Breastfed as a baby	0.8	1.0	7.0	-0.3	-0.2	0.7	1.7	0.1	-0.4	0.9	1.0	-2.6	0.2	0.1	0.0	-0.1
Tense / ‘highly strung’	0.8	1.2	7.7	1.6	0.5	0.6	-1.6	0.9	0.7	-0.4	-0.6	2.8	-0.2	0.7	-0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.3	-0.5	-0.1	-0.3	-1.0	-0.4	-0.2	-0.2	-0.4	0.2	-0.3	-0.3	-1.2	0.1
Hair/balding pattern: Pattern 4	0.9	2.1	4.9	-2.2	-1.2	-0.2	-0.8	-2.2	-1.4	-1.7	-1.7	-0.1	1.3	-1.7	-0.7	1.6
Birth weight of first child	0.2	0.4	2.4	0.1	-0.5	-0.2	-0.4	-0.6	-0.2	-0.6	-0.4	0.2	0.8	-0.1	1.6	0.5
Peak expiratory flow (PEF)	0.3	0.6	4.3	0.1	-0.1	-0.6	-0.8	0.2	-0.1	-0.7	-0.7	0.9	-0.4	-0.6	-2.1	0.3
Pulse wave reflection index	0.7	0.9	3.4	1.1	0.2	1.2	1.0	0.6	0.7	0.9	0.9	-0.0	0.7	1.1	1.9	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	0.9	-1.0	-0.4	-1.0	0.2	-0.1	-0.7	-0.8	1.1	1.1	0.1	0.6	0.5
Loud music exposure frequency	0.5	0.5	1.6	0.5	0.8	-0.0	1.2	0.7	0.2	0.9	0.7	-1.3	0.1	0.4	0.7	-0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.5	1.8	1.1	1.2	1.0	1.9	1.2	1.6	1.5	0.3	-0.8	1.4	1.1	-1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.3	-0.9	-0.7	-2.1	-0.5	-0.5	-1.4	-0.1	-0.5	-0.1	-0.7	-1.3	-1.3	0.9
Blood clot in the leg (DVT)	0.3	0.4	1.7	-0.4	0.8	0.7	0.1	-0.5	-0.1	0.6	0.5	-1.3	-0.8	-0.1	-1.0	-0.3
Medication: Paracetamol	0.7	1.2	5.1	-1.2	-0.0	-0.2	-1.7	-1.0	-0.4	-1.2	-1.1	0.9	-0.5	-1.0	-2.3	0.7
Headache pain in last month	0.4	0.7	1.4	0.0	-1.0	1.0	-1.1	-0.3	0.0	-1.1	-1.0	1.2	0.9	-0.3	-0.7	0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	0.8	-1.0	0.9	-1.0	0.2	0.1	-0.5	-0.5	1.2	-0.5	-0.1	-0.2	0.1
Glaucoma (self-reported)	3.2	3.8	11.4	1.4	3.4	0.3	2.4	2.2	1.8	2.1	2.0	-0.3	-0.2	2.2	2.1	-2.0
Gout (self-reported)	0.2	0.3	0.8	-0.7	0.4	0.9	0.4	-0.8	0.6	0.0	0.3	-0.4	-0.3	-0.3	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	0.6	1.5	0.7	1.5	0.7	1.1	1.2	1.2	-0.8	0.8	1.3	1.1	-1.1
Medication: Amlodipine	0.2	0.2	0.8	0.4	-0.2	0.9	-0.8	-0.4	0.6	-0.5	-0.4	0.7	0.3	-0.0	-0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.9	0.2	0.8	1.7	-0.5	-0.3	1.4	-0.0	0.2	1.4	-1.1	0.5	0.6	-1.0
Birth weight	0.8	1.6	4.1	-0.1	1.4	0.0	2.0	1.1	0.8	2.0	2.0	-0.5	-1.6	0.8	-0.1	-1.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	-0.6	-1.0	-1.1	-0.8	-0.5	-0.8	-0.5	-0.7	-0.6	0.0	-0.7	-0.2	0.7
High blood pressure (siblings)	0.3	0.4	2.3	0.4	1.1	0.1	0.1	0.3	0.6	0.5	0.6	0.1	-1.5	0.3	-0.2	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.7	5.4	-0.1	-0.4	0.4	-1.0	0.1	-0.3	-0.3	-0.3	0.5	-1.3	-0.6	-2.3	0.2
Body fat percentage	0.5	2.0	4.2	1.6	1.9	0.1	1.6	1.9	0.8	2.1	1.6	-0.7	-0.2	1.9	0.7	-1.3
Leg fat percentage (right)	0.5	1.7	2.9	1.6	1.7	-0.2	1.5	1.7	0.5	1.7	1.3	-0.9	0.4	1.6	1.7	-0.8
Arm fat-free mass (right)	1.0	5.0	13.1	1.8	3.6	1.3	1.8	2.1	2.1	2.5	2.5	0.6	-3.2	1.9	-1.0	-2.6
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.4	0.3	0.4	0.5	0.0	-0.3	0.2	0.2	-0.4	-0.1	-0.2	0.6	0.1
Comparative body size at age 10	0.6	1.8	4.4	1.7	0.6	1.2	1.4	2.1	0.5	1.3	1.0	-1.1	0.7	1.8	1.8	-0.7
Number of full brothers	2.2	2.7	9.1	-1.8	-1.7	-2.1	0.4	-1.3	-2.6	-0.4	-0.5	-3.0	0.0	-2.0	-0.4	1.7
Worry too long after embarrassment	2.4	4.0	7.7	-0.8	-2.1	-1.5	-1.9	-1.8	-2.5	-2.5	-2.4	0.3	2.3	-2.2	1.4	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	-0.8	0.3	0.1	-0.7	-0.7	0.3	-0.4	-0.4	0.4	-1.2	-0.8	-1.3	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	2.4	-0.7	-1.1	-0.7	-1.6	-0.4	-0.3	-0.4	-0.7	0.6	-0.7	-0.4	-0.8	0.3
Number of children fathered	0.4	0.5	1.4	-0.4	-1.2	-1.0	-0.1	-0.3	-1.2	-0.2	-0.6	0.1	0.7	-0.5	0.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.8	-1.9	-0.0	-0.6	-0.0	-1.7	-0.6	-0.7	-0.5	-1.3	0.2	-1.3	-0.3	0.5
Age at first live birth	0.4	0.8	2.4	-1.5	-1.3	-0.6	0.2	-0.7	-1.1	-0.2	-0.2	-1.6	-0.2	-0.9	-0.1	0.7
Pulse wave peak to peak time	0.6	0.7	5.0	-0.5	-0.5	-0.5	-0.7	-0.3	-0.3	-0.2	-0.4	0.9	-1.2	-0.6	-2.2	0.2
Health satisfaction	1.0	1.2	5.0	2.2	1.3	0.6	0.2	2.0	0.8	0.8	0.5	0.4	0.8	1.5	0.6	-0.6
Shortness of breath walking on level ground	0.6	0.7	2.3	-0.2	0.8	0.8	0.1	-0.3	1.4	-0.0	0.3	1.0	-0.9	0.1	-1.5	-1.1
Qualifications: College or University degree	0.3	0.9	2.8	0.2	1.7	0.9	-0.0	0.3	1.7	0.0	0.5	1.4	-0.7	0.6	-1.1	-1.2
Eye problems/disorders: None of the above	0.7	0.8	3.9	-0.4	-0.4	2.0	0.2	-0.5	1.2	0.2	0.8	-0.6	-1.3	-0.2	-0.5	-1.1
Mouth/teeth dental problems: Loose teeth	1.9	2.3	15.4	1.0	-0.3	1.5	-2.2	0.0	1.3	-1.3	-1.1	3.9	0.3	0.4	-1.3	-0.4
Emphysema/chronic bronchitis	0.7	0.8	5.0	-0.4	0.2	-1.3	0.7	0.0	-1.3	0.5	0.3	-2.2	0.1	-0.4	-0.0	0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	2.3	0.7	-1.5	-0.9	0.1	0.4	-0.7	0.2	-0.1	-0.3	0.3	0.0	0.9	0.5
Neck or shoulder pain in last month	0.2	0.3	1.3	-1.1	0.4	-0.2	-0.1	-0.6	-0.5	-0.1	-0.3	-0.3	0.4	-0.5	-1.0	0.3
Medication: Blood pressure	0.1	0.2	1.4	-0.2	0.8	-1.2	0.3	-0.0	-0.2	0.3	0.1	-0.4	0.6	0.1	0.2	0.1
Angina (self-reported)	1.1	1.5	3.3	0.0	1.8	1.8	1.6	0.1	1.8	0.9	1.4	-0.0	-0.8	0.9	-0.3	-1.7
Migraine (self-reported)	1.9	2.3	7.6	1.4	0.5	2.8	1.1	1.4	2.2	0.7	0.9	1.0	1.0	2.3	1.2	-1.7
Medication: Ibuprofen	0.2	0.3	1.4	-0.1	0.7	1.2	0.3	0.1	0.4	0.4	0.5	-0.2	-0.4	0.3	0.6	-0.5
Medication: Allopurinol	0.4	0.5	1.6	-1.1	0.4	0.4	0.3	-1.2	0.2	-0.1	0.1	-0.4	-0.7	-0.8	-1.3	-0.3
Medication: Omeprazole	0.7	0.8	3.6	-0.5	1.3	1.1	-0.2	-0.5	1.9	-0.6	-0.0	1.2	-0.1	0.1	-0.7	-1.3
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.2	0.9	1.2	1.1	0.4	0.6	1.4	1.3	-1.1	-0.2	1.0	0.6	-0.9
Mean time to correctly identify matches	2.3	4.4	10.2	1.6	2.4	1.3	1.9	2.0	1.6	2.9	2.7	-0.5	-3.2	1.7	-1.4	-2.4
Heart disease (mother)	0.2	0.2	0.6	-0.8	0.3	-0.7	-0.5	-0.7	0.1	-0.5	-0.3	-0.1	-0.8	-0.5	0.1	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	6.1	0.1	2.5	1.8	2.2	0.4	1.6	1.7	1.9	-0.2	-1.4	1.5	0.7	-1.8
Whole body fat mass	0.7	3.0	6.4	1.8	2.4	0.3	1.9	2.2	1.1	2.5	2.1	-0.6	-1.1	2.0	0.4	-1.7
Leg fat mass (right)	0.6	2.3	4.9	1.9	2.2	0.0	1.6	2.1	0.7	2.2	1.8	-0.6	-0.8	1.8	0.8	-1.3
Arm predicted mass (right)	0.8	4.0	12.1	1.6	3.5	1.2	1.4	1.8	1.9	2.1	2.1	0.8	-2.9	1.6	-1.0	-2.3
Pulse rate, automated reading	0.4	1.3	4.7	1.1	2.2	0.8	1.0	0.7	1.6	0.1	0.7	0.8	-0.0	0.7	1.9	-1.2
Alcohol intake frequency.	0.5	1.1	3.9	0.1	1.0	1.2	0.8	0.1	0.3	1.5	1.3	-0.9	-2.0	0.6	-1.3	-1.0
Comparative height size at age 10	0.1	0.7	2.9	-0.0	1.3	-1.7	-0.2	0.6	0.3	0.4	0.4	0.4	-1.4	-0.1	-0.9	-0.4
Number of full sisters	0.1	0.2	0.4	0.6	-0.3	-0.5	-0.3	0.4	-0.4	-0.2	-0.4	0.2	-0.1	-0.5	-0.5	0.3
Suffer from ‘nerves’	1.1	1.7	5.8	1.3	1.0	2.4	0.7	0.8	2.2	0.3	0.8	1.4	-0.1	1.2	0.6	-1.6
Overall health rating	0.5	1.1	2.7	1.0	0.8	0.6	1.1	1.5	-0.1	1.6	1.2	-1.5	-0.0	1.1	0.7	-0.5
Chest pain or discomfort	0.2	0.3	0.7	0.0	-0.8	0.4	-0.4	-0.0	-0.8	-0.3	-0.6	-0.2	0.6	-0.3	0.0	0.8
Had major operations	0.6	0.7	2.8	-0.1	0.7	1.0	1.1	-0.0	0.4	1.1	1.1	-1.7	-0.6	0.1	-0.6	-0.8
Age at last live birth	0.4	0.6	1.9	-0.9	-1.4	-0.7	-0.4	-0.7	-0.7	-0.7	-0.7	-0.1	0.7	-0.8	-0.3	0.8
Family relationship satisfaction	0.6	0.8	5.3	0.2	-0.0	0.2	0.1	-0.1	-0.1	-0.5	-0.3	-0.4	2.3	0.4	2.0	0.5
Leg pain on walking	0.6	0.7	2.0	1.2	1.2	0.5	0.8	1.4	0.2	0.8	0.6	-0.4	0.5	0.9	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	5.8	-0.5	-0.2	0.3	0.1	-0.6	-0.1	-0.9	-0.7	-0.4	2.2	-0.4	2.4	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-1.0	-0.8	-0.3	-1.0	-1.1	0.1	-0.9	-0.6	0.5	-0.6	-0.8	-0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.1	0.9	0.1	0.7	0.7	0.6	1.0	1.1	0.2	-1.3	0.5	-0.6	-0.9
Medication: Aspirin	0.5	0.6	2.0	0.4	1.4	1.2	0.0	0.2	1.2	0.2	0.3	1.2	-0.1	0.7	-0.3	-0.9
Supplements: Vitamin C	0.4	0.5	1.2	-0.6	-0.5	-0.4	-0.7	-0.5	-0.9	-0.7	-0.8	-0.0	1.1	-0.4	0.5	1.1
Knee pain experienced in last month	2.4	3.7	10.4	-1.3	-2.0	-2.6	-1.3	-1.5	-3.2	-1.2	-1.7	-1.7	1.7	-1.4	1.1	2.9
Hypertension (Self-reported)	0.3	0.7	2.5	1.6	0.5	0.6	0.1	0.9	1.0	0.7	0.4	1.0	0.4	1.3	0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.2	0.8	-0.1	0.3	-0.1	0.6	0.2	0.4	0.1	-0.7	0.1	-0.7	-0.6
Illnesses of father: Heart disease	0.3	0.5	1.5	0.3	1.0	0.8	0.4	0.7	0.9	0.5	0.4	0.5	0.3	1.2	-0.3	-0.8
Illnesses of siblings: Diabetes	0.1	0.2	1.0	-0.2	0.2	-0.4	1.0	-0.0	-0.1	0.5	0.4	-0.7	0.3	0.0	0.3	-0.1
Smoking status: Previous	0.2	0.4	1.1	-0.7	-0.3	-1.1	0.0	-0.2	-0.4	0.5	0.4	-0.9	-0.8	-0.4	-0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	-0.4	0.8	-0.4	0.5	0.3	0.5	0.8	0.8	-0.4	-1.2	-0.1	-1.2	-0.8
Whole body fat-free mass	0.8	4.4	11.5	1.3	3.4	1.2	1.6	1.7	2.0	2.4	2.4	0.4	-3.4	1.5	-1.4	-2.5
Leg fat-free mass (right)	1.0	5.2	12.5	1.4	3.0	1.9	2.0	2.0	2.3	2.7	2.7	0.3	-3.5	1.8	-1.5	-2.9
Arm fat percentage (left)	0.8	3.3	7.0	1.8	2.0	0.7	2.3	2.3	1.3	2.7	2.3	-0.9	-0.9	2.2	0.7	-1.9
Average weekly red wine intake	0.4	0.6	2.3	0.3	-0.3	-1.5	0.2	-0.1	-0.8	-0.5	-0.5	-0.3	1.1	-0.6	1.1	0.8
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.7	-1.9	-0.4	-0.9	-1.2	-2.2	-0.9	-1.1	-1.0	-0.3	-0.1	-1.7	-0.5	0.9
Mood swings	0.2	0.4	1.5	1.1	-0.2	-0.3	-0.1	0.8	0.4	0.3	0.2	1.2	-0.0	0.8	-0.1	-0.4
Loneliness, isolation	0.4	0.6	3.8	0.7	0.2	-0.3	0.6	0.4	-0.1	0.2	0.1	-0.1	1.4	0.7	2.0	0.2
Long-standing illness, disability or infirmity	0.3	0.5	3.0	-0.5	1.7	-0.1	0.8	0.1	0.3	0.7	0.7	-0.8	0.4	0.5	0.5	-0.5
Ever had bowel cancer screening	0.4	0.4	1.7	0.7	0.0	-0.0	-1.2	0.3	0.0	-0.6	-0.8	1.3	0.2	0.1	-0.8	0.3
Diabetes diagnosed by doctor	1.3	2.1	4.7	-0.1	2.0	1.1	1.7	0.6	1.5	1.7	1.6	-0.4	-2.2	1.0	-1.4	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	4.9	-1.3	-1.8	-2.2	-0.6	-1.3	-1.9	-1.7	-1.7	-0.1	2.2	-1.8	1.5	2.1
Friendships satisfaction	0.3	0.3	1.8	0.5	-0.5	-0.3	0.4	0.2	-0.4	-0.0	-0.1	-0.5	1.2	0.1	1.3	0.4
Qualifications: nursing, teaching	0.6	0.9	3.3	1.2	-0.4	-0.9	-0.9	0.5	-0.6	-0.6	-0.9	0.6	1.8	0.4	1.4	1.0
Commuting to job workplace: Walk	0.2	0.2	0.8	0.7	0.4	0.9	-0.4	0.3	-0.2	0.1	0.0	0.3	-0.5	0.3	-0.4	0.0
Eye problems/disorders: Cataract	2.4	2.8	7.1	-1.0	-1.4	-1.8	-1.7	-1.0	-1.7	-1.7	-2.2	1.5	2.7	-1.0	1.1	2.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.9	-1.2	-1.9	-1.4	-1.0	-1.7	-2.2	-1.6	-1.7	-1.0	1.1	-1.9	-0.5	2.2
Medication for cholesterol	0.4	0.6	1.4	-1.2	-0.4	-0.5	0.7	-0.7	-1.0	-0.2	-0.1	-1.2	0.2	-0.9	0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.1	0.5	1.0	-0.7	1.0	1.0	-0.1	1.5	1.3	-1.3	-2.0	0.4	-1.0	-0.7
Back pain experienced in last month	0.6	0.9	3.3	0.0	1.3	-0.1	1.8	0.4	0.1	0.9	1.1	-1.8	0.5	0.0	0.7	-0.4
Mineral and other dietary supplements	1.1	1.5	2.7	0.5	1.2	1.1	1.6	0.7	1.4	1.4	1.6	-1.0	-1.1	1.1	-0.6	-1.6
Breast cancer (self-reported)	0.8	0.9	2.7	-0.9	-0.8	-0.0	-1.6	-1.6	0.3	-1.4	-1.1	1.0	0.4	-0.8	-0.8	0.4
Asthma (self-reported)	0.3	0.7	2.4	0.2	0.7	1.5	0.3	0.5	0.6	1.0	1.0	-0.0	-1.2	0.6	0.5	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.3	-0.4	1.1	0.8	0.5	-0.1	0.8	0.6	0.8	-0.3	-0.8	0.2	-1.0	-1.0
Osteoarthritis (self-reported)	0.3	0.4	1.3	-1.0	0.3	-0.3	-0.7	-1.1	-0.0	-0.9	-0.6	0.3	-0.1	-0.7	0.2	0.4
Medication: Aspirin	0.9	1.2	3.0	0.6	1.7	1.3	0.3	0.5	1.7	0.6	0.7	1.5	-0.6	1.2	-0.6	-1.5
Medication: Gliclazide	0.2	0.2	1.7	-0.3	0.4	-1.3	0.6	-0.2	-0.6	0.0	-0.0	-0.5	0.0	-0.3	0.1	0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	1.2	-0.3	-0.2	-0.9	0.3	-0.4	-0.7	-0.1	-0.1	-0.6	0.5	-0.5	1.1	0.6
Smoking status: Current	0.2	0.3	1.1	1.1	-0.3	0.5	-0.1	0.6	0.1	0.2	0.3	1.0	-0.7	0.7	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.3	0.8	-0.5	-0.5	-1.8	0.3	0.3	-1.0	-1.0	2.1	-0.2	-0.3	-1.7	0.2
Whole body water mass	0.8	4.8	12.2	1.3	3.5	1.3	1.8	1.8	2.1	2.5	2.5	0.4	-3.5	1.6	-1.4	-2.6
Leg predicted mass (right)	1.0	5.2	12.6	1.3	2.9	1.9	2.0	2.0	2.3	2.7	2.7	0.3	-3.5	1.8	-1.5	-2.8
Arm fat mass (left)	1.2	4.8	9.6	2.1	2.9	0.9	2.4	2.7	1.7	3.1	2.8	-0.5	-1.8	2.4	0.2	-2.4
Number of self-reported non-cancer illnesses	0.1	0.2	1.8	-0.6	1.3	-0.0	-0.2	-0.4	0.1	-0.1	-0.1	-0.4	0.4	0.1	0.2	-0.0
Average weekly champagne plus white wine intake	1.9	2.6	7.2	-0.1	-1.3	-0.7	-2.7	-1.4	-0.7	-2.7	-2.3	1.9	1.0	-1.6	-0.1	1.5
Miserableness	0.2	0.3	1.4	0.5	0.5	-0.8	-0.6	0.5	0.1	-0.2	-0.3	1.2	0.7	0.2	-0.4	0.0
Guilty feelings	0.3	0.4	1.5	0.8	-0.2	-1.1	-0.6	0.1	-1.2	-0.3	-0.6	0.3	0.5	-0.0	0.0	1.1
Wears glasses or contact lenses	0.1	0.1	0.7	-0.0	0.9	0.8	0.2	-0.2	0.2	0.1	0.0	-0.1	0.1	0.1	0.1	-0.1
Ever taken oral contraceptive pill	2.1	2.3	5.3	-1.5	-1.8	-1.9	-0.7	-1.4	-2.3	-0.9	-1.1	-1.5	1.2	-1.7	0.8	2.0
Hearing aid user	1.3	1.5	6.8	-0.9	0.5	-1.0	1.3	0.3	-0.9	1.4	1.2	-2.6	-1.1	-0.2	-1.7	-0.0
Mother’s age at death	0.4	0.5	1.9	-0.4	1.4	1.0	0.3	-0.1	0.9	0.3	0.5	-0.5	0.8	0.5	0.9	-0.7
Financial situation satisfaction	1.4	1.7	3.9	1.2	1.5	1.5	1.6	0.8	1.6	0.8	1.1	0.4	0.6	1.5	2.0	-1.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.6	0.1	-0.9	0.8	-1.1	-0.8	0.1	-1.6	-1.2	1.1	1.6	-0.4	0.2	0.7
Commuting to job workplace: Public transport	2.0	2.4	5.3	-0.7	-0.6	-2.1	-1.0	-0.8	-2.2	-1.5	-1.7	-0.6	2.3	-1.5	1.2	2.2
Eye problems/disorders: Glaucoma	2.3	2.8	5.9	1.6	2.4	-0.1	2.2	2.3	1.1	2.0	1.7	-0.6	-0.1	2.1	1.5	-1.4
Medication: Blood pressure	0.6	1.1	3.0	1.7	0.1	1.3	-0.4	1.0	1.3	0.3	0.2	1.6	0.5	1.3	1.1	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.8	0.0	-0.7	-0.7	-0.6	-0.6	-0.7	-0.8	-0.8	0.4	-0.6	-0.5	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.2	-0.5	-1.5	-1.4	-1.3	-0.6	-1.4	-1.0	-1.2	0.1	0.4	-1.3	-0.4	1.5
High cholesterol (Self-reported)	1.4	2.5	5.3	1.7	1.7	0.7	1.9	1.6	2.0	1.7	1.7	0.2	-0.1	2.3	1.1	-1.9
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.7	0.9	-0.2	0.5	-0.5	0.3	0.4	0.5	-1.0	-0.4	-0.3	0.2	-0.4
Medication: Paracetamol	0.6	1.0	7.5	-1.0	0.6	-0.0	-0.8	-0.3	0.5	-0.1	-0.1	0.9	-1.4	0.0	-2.7	-0.4
Medication: Lisinopril	0.5	0.7	1.4	-1.1	-1.0	-0.5	-1.2	-1.0	-0.5	-1.1	-1.0	0.5	0.5	-0.7	0.1	0.8
Medication: Atorvastatin	0.3	0.3	0.9	-0.0	1.0	-0.4	0.8	0.3	0.6	0.7	0.8	-0.2	0.1	0.5	-0.3	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.6	0.5	0.2	0.9	-0.2	0.4	0.9	0.5	0.6	0.7	-1.2	0.6	-1.1	-0.9
Alcohol drinker status: Never	0.5	0.6	1.3	-0.6	-1.1	-0.6	-1.0	-1.1	-0.9	-0.8	-0.8	0.0	0.4	-0.7	-0.5	0.9
Ever smoked	0.0	0.1	0.2	0.2	-0.2	-0.1	0.0	0.1	-0.1	0.3	0.4	0.2	-0.5	0.3	-0.3	-0.1
Basal metabolic rate	0.9	4.8	12.2	1.6	3.5	1.2	1.9	2.1	2.0	2.6	2.6	0.2	-3.2	1.8	-1.1	-2.6
Leg fat percentage (left)	0.6	2.2	4.1	1.8	2.0	0.2	1.6	2.0	0.7	2.0	1.6	-0.8	0.1	2.0	1.4	-1.2
Arm fat-free mass (left)	0.9	4.7	14.4	1.8	3.8	1.0	1.7	2.1	1.9	2.5	2.5	0.5	-2.8	1.9	-0.7	-2.5
Number of operations (self-reported)	0.2	0.4	1.7	-0.6	-0.2	-0.6	-0.3	-0.4	-0.5	-0.2	-0.2	-0.7	-0.8	-0.7	-1.3	0.3
Average weekly beer plus cider intake	1.8	2.6	7.4	-1.0	-2.7	-1.6	-1.4	-1.1	-2.2	-1.4	-1.7	-0.5	1.7	-1.3	0.2	2.2
Irritability	0.4	0.7	2.3	0.3	-0.8	-1.2	-1.3	0.4	-0.8	-0.6	-0.9	1.5	-0.0	-0.4	-0.2	0.9
Risk taking	0.2	0.3	2.3	-0.4	0.6	-0.6	0.0	0.1	0.1	0.2	0.1	-0.8	-0.7	-0.2	-1.5	-0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.6	-0.1	-0.0	-1.9	0.5	0.1	-1.4	0.2	-0.1	-1.4	1.0	-0.3	1.3	1.0
Fractured/broken bones in last 5 years	0.5	0.7	1.9	-1.1	-0.1	-0.6	0.4	-0.9	-1.2	0.1	0.1	-1.4	-0.3	-0.8	1.3	0.7
Age started oral contraceptive pill	0.7	0.8	2.9	1.6	0.9	-1.7	-0.2	0.9	-0.6	0.3	0.1	-0.2	0.8	0.2	1.4	0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.3	0.1	-0.3	0.4	-1.5	-0.8	-0.6	-1.1	-1.4	1.1	0.7	-0.6	0.0	0.8
Ever depressed for a whole week	0.6	0.8	3.8	-0.1	1.5	-0.7	1.2	-0.0	-0.3	0.8	0.9	-1.9	-0.4	-0.3	-0.2	-0.2
Unable to work because of sickness or disability	1.1	1.4	4.2	-2.0	0.7	-0.2	0.8	-1.1	-0.3	0.8	0.6	-1.8	-1.7	-0.8	-2.1	-0.4
Commuting to job workplace: Cycle	0.9	1.0	2.4	1.2	0.7	0.7	0.5	1.5	0.7	1.5	1.1	0.6	-1.1	1.5	-0.0	-1.0
Myopia	1.1	1.5	6.8	-0.2	0.5	1.9	-1.1	-0.5	0.9	-0.5	-0.3	1.6	-1.8	-0.7	-2.6	-0.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.6	-0.6	-0.3	0.2	0.1	-0.1	-0.3	-0.2	0.0	-0.1	-0.4	-0.4	-0.8	0.2
Cholesterol lowering medication	0.4	0.6	2.7	1.3	-0.1	-0.0	-0.4	0.6	0.7	-0.0	-0.2	1.7	0.6	0.9	0.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.8	-0.3	1.6	0.7	-0.3	-0.3	1.9	-0.5	-0.0	1.5	-0.4	0.3	-0.7	-1.3
Pain experienced in last month	0.5	0.8	4.3	-0.0	-0.0	0.8	-0.2	0.1	0.7	0.6	0.6	0.9	-2.1	0.2	-1.6	-0.9
Supplements: Calcium	1.1	1.2	4.5	-0.2	-0.8	-1.3	-2.1	-0.3	-1.2	-1.0	-1.4	1.2	0.4	-0.4	0.3	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	4.3	0.0	-0.3	0.1	-1.4	-0.2	0.4	-0.7	-0.9	2.1	1.2	0.3	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.8	-1.6	-0.2	-0.3	-0.3	-1.4	-0.4	-1.1	-1.1	0.1	2.2	-0.6	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.8	0.0	1.1	1.0	-0.1	-0.3	0.4	0.6	0.5	-0.6	-1.1	0.2	-1.3	-0.6
Heart disease (siblings)	0.7	0.8	1.9	0.4	1.3	-0.7	1.2	1.1	-0.3	1.4	1.0	-1.2	-1.0	0.3	0.2	-0.4
Alcohol drinker status: Previous	1.2	1.4	5.6	-0.1	0.6	-0.3	1.1	0.2	0.1	1.6	1.3	-1.4	-2.4	0.4	-1.8	-0.9
Pack years of smoking	0.1	0.2	0.6	0.7	0.6	-0.8	0.1	0.4	-0.3	0.3	-0.0	0.4	0.0	0.4	-0.1	0.2
Impedance of whole body	1.2	6.1	10.9	-1.4	-3.1	-2.5	-2.6	-1.9	-2.6	-3.0	-3.1	-0.1	3.3	-2.0	0.8	3.2
Leg fat mass (left)	0.7	2.8	5.8	2.0	2.4	0.3	1.7	2.3	0.9	2.4	1.9	-0.5	-0.9	2.1	0.7	-1.5
Arm predicted mass (left)	0.9	4.4	14.3	1.7	3.8	1.2	1.6	1.9	1.9	2.4	2.4	0.7	-2.7	1.8	-0.8	-2.4