Best TWAS P=3.37e-18 · Best GWAS P=1.92e-38 conditioned to 1.63e-34
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATXN10 | 0.04 | 0.02 | blup | 113 | 0.03 | 1.2e-04 | 6.5 | 8.7 | 3.4e-18 | 0.09 | 0.00 | 0.98 | TRUE |
| 7 | GTEx | Lung | ATXN10 | 0.14 | 0.08 | enet | 20 | 0.08 | 5.2e-07 | 7.0 | 8.2 | 2.1e-16 | 0.10 | 0.58 | 0.02 | FALSE |
| 5 | GTEx | Colon Transverse | ATXN10 | 0.24 | 0.04 | lasso | 4 | 0.03 | 9.3e-03 | 7.0 | 8.0 | 1.4e-15 | 0.17 | 0.30 | 0.10 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | ATXN10 | 0.17 | 0.04 | lasso | 5 | 0.03 | 2.6e-03 | 6.6 | 7.8 | 7.2e-15 | 0.08 | 0.19 | 0.04 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ATXN10 | 0.17 | 0.07 | lasso | 6 | 0.04 | 2.6e-02 | 7.0 | 7.5 | 5.7e-14 | 0.05 | 0.11 | 0.06 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ATXN10 | 0.35 | 0.24 | lasso | 5 | 0.22 | 1.9e-12 | 7.0 | 7.4 | 1.0e-13 | 0.06 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | ATXN10 | 0.17 | 0.15 | lasso | 5 | 0.13 | 6.6e-11 | 6.8 | 7.3 | 3.8e-13 | 0.06 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | ATXN10 | 0.29 | 0.25 | enet | 15 | 0.29 | 7.6e-20 | 6.9 | 7.1 | 9.2e-13 | 0.07 | 1.00 | 0.00 | FALSE |
| 1 | GTEx | Artery Tibial | ATXN10 | 0.19 | 0.12 | enet | 8 | 0.12 | 5.7e-10 | 6.9 | 7.0 | 2.6e-12 | 0.03 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | ATXN10 | 0.16 | 0.10 | lasso | 7 | 0.08 | 5.8e-05 | 6.8 | 6.9 | 7.0e-12 | 0.05 | 0.80 | 0.01 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATXN10 | 0.05 | 0.03 | blup | 112 | 0.03 | 9.6e-05 | 6.8 | 5.4 | 7.9e-08 | 0.02 | 0.19 | 0.63 | FALSE |