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chr22:42,202,606-44,282,307

Best TWAS P=1.33e-37 · Best GWAS P=5.21e-44 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	A4GALT	0.20	0.04	enet	33	0.13	2.9e-15	1.8	-9.4	4.8e-21	0.43	0.97	0.03	FALSE
2	GTEx	Adipose Subcutaneous	A4GALT	0.18	0.05	enet	35	0.15	4.1e-12	8.7	-7.3	2.7e-13	0.49	0.06	0.89	FALSE
3	GTEx	Artery Aorta	A4GALT	0.24	0.09	enet	20	0.03	1.1e-02	-13.9	-12.6	1.7e-36	0.84	0.00	1.00	FALSE
4	GTEx	Artery Tibial	TTLL12	0.38	0.08	enet	27	0.21	2.4e-16	-4.7	-5.2	2.3e-07	0.01	1.00	0.00	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	SERHL	0.51	0.09	enet	29	0.26	3.5e-09	-4.4	-5.2	2.5e-07	0.21	0.27	0.04	TRUE
6	GTEx	Cells Transformed fibroblasts	TTLL12	0.36	0.08	enet	17	0.23	5.3e-17	4.1	-5.2	1.9e-07	0.06	1.00	0.00	FALSE
7	GTEx	Cells Transformed fibroblasts	A4GALT	0.37	0.03	lasso	8	0.20	1.2e-14	3.2	-5.5	3.8e-08	0.47	0.02	0.98	FALSE
8	GTEx	Cells Transformed fibroblasts	SERHL	0.61	0.12	enet	35	0.23	3.6e-17	-3.0	-5.6	2.5e-08	0.30	1.00	0.00	TRUE
9	GTEx	Esophagus Gastroesophageal Junction	SERHL	0.36	0.20	enet	17	0.18	2.9e-07	-3.0	-5.2	1.6e-07	0.23	0.60	0.02	TRUE
10	GTEx	Esophagus Muscularis	TTLL12	0.47	0.23	lasso	6	0.32	6.4e-20	4.1	-5.3	1.1e-07	0.04	1.00	0.00	FALSE
11	GTEx	Esophagus Muscularis	A4GALT	0.38	0.11	lasso	9	0.28	3.8e-17	2.8	-9.5	1.6e-21	0.59	0.25	0.74	FALSE
12	GTEx	Heart Atrial Appendage	CYB5R3	0.21	0.15	enet	13	0.14	5.2e-07	5.4	5.9	3.5e-09	-0.29	0.76	0.02	FALSE
13	GTEx	Heart Atrial Appendage	A4GALT	0.18	-0.01	enet	6	-0.01	7.2e-01	-12.4	-11.6	3.0e-31	0.81	0.01	0.89	FALSE
14	GTEx	Lung	TTLL12	0.32	0.07	enet	21	0.20	7.2e-15	4.2	-5.5	4.5e-08	0.02	1.00	0.00	FALSE
15	GTEx	Lung	A4GALT	0.17	0.01	enet	18	0.03	1.5e-03	-13.9	-11.3	1.1e-29	0.64	0.00	0.99	FALSE
16	GTEx	Muscle Skeletal	CYB5R3	0.14	0.05	enet	35	0.06	2.3e-06	-3.0	6.6	3.5e-11	-0.35	0.95	0.01	FALSE
17	GTEx	Muscle Skeletal	A4GALT	0.21	0.17	lasso	3	0.16	1.1e-15	10.1	-11.5	1.0e-30	0.63	0.99	0.01	FALSE
18	GTEx	Muscle Skeletal	SERHL	0.33	0.16	lasso	7	0.19	3.6e-18	-4.4	-5.2	2.6e-07	0.30	1.00	0.00	TRUE
19	GTEx	Prostate	SERHL2	0.22	0.08	enet	33	0.03	7.7e-02	10.1	6.3	2.8e-10	-0.39	0.06	0.06	FALSE
20	GTEx	Skin Sun Exposed Lower leg	RRP7B	0.18	0.04	enet	25	0.12	4.2e-10	-3.0	6.8	1.5e-11	-0.22	0.91	0.01	FALSE
21	GTEx	Skin Sun Exposed Lower leg	SERHL2	0.11	0.04	enet	17	0.06	8.6e-06	-3.0	6.9	6.3e-12	-0.20	0.64	0.04	TRUE
22	GTEx	Testis	A4GALT	0.31	0.16	lasso	4	0.27	3.2e-12	-4.0	-10.1	8.3e-24	0.66	0.22	0.78	FALSE
23	GTEx	Thyroid	TTLL12	0.26	0.05	lasso	9	0.14	3.9e-11	-3.4	-5.6	2.5e-08	0.02	1.00	0.00	TRUE
24	GTEx	Whole Blood	A4GALT	0.20	0.07	enet	7	0.05	3.5e-05	-3.1	-8.1	4.5e-16	0.48	0.26	0.73	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	A4GALT	0.03	0.01	enet	12	0.03	2.8e-06	3.2	-5.8	5.3e-09	0.44	0.06	0.18	TRUE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	A4GALT	0.10	0.00	blup	66	0.06	1.6e-04	1.2	-6.2	6.0e-10	0.47	0.02	0.69	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARFGAP3	0.05	0.00	blup	74	0.01	3.7e-02	-3.3	8.6	7.9e-18	-0.23	0.04	0.08	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	A4GALT	0.09	0.06	lasso	2	0.05	1.5e-06	10.1	-10.5	1.1e-25	0.53	0.64	0.22	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	A4GALT	0.09	0.01	blup	65	0.07	8.0e-09	-12.2	-9.0	2.8e-19	0.56	0.02	0.91	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	A4GALT	0.04	0.01	blup	66	0.02	1.5e-03	-12.4	-10.9	1.1e-27	0.66	0.01	0.78	FALSE
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	A4GALT	0.15	0.12	lasso	3	0.06	1.3e-03	-12.4	-12.8	1.3e-37	0.86	0.02	0.71	TRUE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	A4GALT	0.07	0.03	blup	66	0.04	3.8e-05	8.7	11.0	5.5e-28	-0.58	0.02	0.62	FALSE