TWAS hub - ATXN10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1480	0.0540	2.7e-03	0.032	NA	0.065	NA	0.057	9.0e-03	NA	2.7e-04	NA	6.5e-04
2	GTEx	Artery Tibial	0.1881	0.0476	4.1e-06	0.125	NA	0.124	NA	0.123	5.3e-10	NA	5.7e-10	NA	7.9e-10
3	GTEx	Breast Mammary Tissue	0.1620	0.0550	3.8e-04	0.100	NA	0.071	NA	0.081	8.5e-06	NA	1.6e-04	NA	5.8e-05
4	GTEx	Breast Mammary Tissue (Female)	0.1713	0.0740	9.6e-03	0.069	NA	0.027	NA	0.039	4.3e-03	NA	5.4e-02	NA	2.6e-02
5	GTEx	Cells Transformed fibroblasts	0.1740	0.0580	5.1e-04	0.037	NA	0.016	NA	0.030	8.9e-04	NA	2.1e-02	NA	2.6e-03
6	GTEx	Colon Transverse	0.2360	0.0810	1.9e-03	0.037	NA	0.022	NA	0.034	7.0e-03	NA	3.1e-02	NA	9.3e-03
7	GTEx	Esophagus Mucosa	0.2880	0.0510	4.6e-13	0.253	NA	0.292	NA	0.292	5.0e-17	NA	7.7e-20	NA	7.7e-20
8	GTEx	Lung	0.1410	0.0459	2.2e-04	0.077	NA	0.084	NA	0.080	1.7e-06	NA	5.2e-07	NA	9.6e-07
9	GTEx	Nerve Tibial	0.1536	0.0583	3.5e-03	0.061	NA	0.039	NA	0.036	4.1e-05	NA	8.6e-04	NA	1.4e-03
10	GTEx	Skin Not Sun Exposed Suprapubic	0.3460	0.0710	4.8e-08	0.240	NA	0.175	NA	0.223	2.3e-13	NA	7.0e-10	NA	1.9e-12
11	GTEx	Skin Sun Exposed Lower leg	0.1700	0.0400	1.4e-07	0.151	NA	0.114	NA	0.130	1.6e-12	NA	1.1e-09	NA	6.6e-11
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.0476	0.0223	3.2e-04	0.033	0.034	0.021	NA	0.026	1.2e-04	9.5e-05	1.7e-03	NA	5.7e-04
13	TCGA	Lung Squamous Cell Carcinoma	0.0421	0.0213	6.4e-04	0.020	0.032	0.018	NA	0.017	2.3e-03	1.2e-04	3.7e-03	NA	4.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Hearing difficulty/problems with background noise	6.5	10.4	16.6	-2.0	-3.0	-3.2	-3.7	-2.7	-4.1	-3.8	-2.7	-1.5	-3.7	-3.5	-3.1	-3.8
Eye problems/disorders: None of the above	5.4	6.2	11.4	3.4	2.2	2.7	2.4	1.5	2.9	2.4	3.3	1.2	2.7	2.6	2.4	2.0
Medication: Lansoprazole	5.3	6.1	9.7	1.7	3.1	2.8	2.8	2.1	2.8	2.9	1.2	1.4	2.9	2.8	2.1	2.4
Blood Red Count	5.1	49.7	75.7	3.5	7.0	6.9	7.5	7.8	8.0	7.1	8.2	5.1	7.4	7.3	5.4	8.7
Breast Cancer	5.0	12.0	18.8	-2.7	-3.6	-3.6	-3.0	-3.0	-3.5	-4.1	-2.7	-2.6	-3.5	-3.9	-4.1	-4.3
Eye problems/disorders: Glaucoma	5.0	5.9	11.2	-3.3	-2.1	-2.7	-2.2	-2.4	-2.4	-2.3	-2.6	-1.7	-2.7	-2.6	-2.2	-1.8
Glaucoma (self-reported)	4.9	5.8	10.3	-3.2	-2.2	-2.6	-2.1	-2.2	-2.3	-2.3	-2.4	-2.6	-2.6	-2.5	-2.1	-2.1
Average weekly spirits intake	4.0	4.9	7.6	1.5	2.8	2.2	2.1	1.9	2.2	2.4	2.5	0.8	2.5	2.4	2.4	2.5
Relative age voice broke	3.7	5.7	8.2	-2.6	-2.5	-2.9	-2.7	-1.8	-2.4	-2.7	-1.6	0.0	-2.9	-2.7	-2.7	-2.1
Number of full brothers	3.6	4.5	8.8	-2.1	-2.3	-1.9	-2.2	-3.0	-2.2	-1.7	-1.5	-1.5	-2.3	-2.0	-2.2	-2.4
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	6.4	-0.4	2.2	2.1	2.5	2.5	2.3	2.2	1.0	0.7	2.4	2.2	1.9	2.5
Pulse rate	3.5	6.0	14.9	1.4	2.5	2.4	2.1	3.9	3.0	2.5	2.2	1.0	2.7	2.5	1.6	2.7
Shortness of breath walking on level ground	3.5	4.2	14.4	3.8	2.6	2.1	0.9	1.4	1.7	1.9	2.1	0.7	1.8	2.0	2.4	1.2
Relative age of first facial hair	3.2	6.6	9.9	-2.2	-2.9	-3.1	-2.7	-2.0	-2.3	-3.0	-1.1	0.5	-3.0	-3.1	-2.6	-3.0
Schizophrenia vs Biploar Disorder	3.1	4.0	6.4	-2.2	-1.5	-1.9	-1.4	-2.5	-2.2	-2.1	-2.2	-1.5	-2.0	-2.0	-2.1	-2.3
Alzheimer’s Disease (in father)	3.0	3.2	9.0	-3.0	-2.0	-1.9	-1.5	-1.2	-1.4	-1.6	-1.8	-1.7	-1.6	-1.8	-2.3	-0.7
Mouth/teeth dental problems: Loose teeth	3.0	3.5	6.5	1.1	2.0	2.5	2.0	0.8	1.9	2.5	1.3	1.6	2.2	2.4	1.5	1.5
Age started oral contraceptive pill	3.0	3.8	12.7	2.8	1.6	1.5	1.3	3.6	0.5	2.0	0.1	1.7	1.4	1.9	1.8	2.6
Average weekly red wine intake	2.9	4.3	6.5	-1.9	-2.5	-2.2	-2.3	-1.3	-2.3	-2.2	-1.6	-1.9	-2.3	-2.2	-2.6	-1.5
Migraine (self-reported)	2.7	3.3	6.2	2.5	2.3	2.2	1.6	1.2	2.1	1.9	1.6	0.6	2.0	2.1	1.2	1.4
Pain experienced in last month	2.7	4.6	6.2	2.1	2.1	2.4	2.0	2.5	2.0	2.4	1.7	1.4	2.2	2.5	2.3	2.0
Maternal smoking around birth	2.6	3.8	9.3	-0.9	-1.5	-1.9	-1.9	-3.0	-1.5	-2.1	-1.6	-1.7	-2.0	-2.1	-1.8	-2.4
Number of children fathered	2.6	2.9	5.9	-1.3	-1.4	-1.7	-1.7	-2.0	-1.9	-1.5	-2.4	-0.8	-1.9	-1.8	-1.3	-1.9
Hair/balding pattern: Pattern 3	2.3	3.5	11.1	2.1	2.0	1.7	1.4	3.3	1.0	1.6	0.5	1.7	1.6	1.8	2.0	2.0
Lung cancer (father)	2.2	2.5	4.8	-1.4	-1.8	-1.3	-1.7	-2.2	-1.4	-1.7	-0.4	1.1	-1.5	-1.5	-1.9	-2.1
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	5.1	1.3	1.7	2.0	2.1	1.2	2.1	2.3	-0.2	0.6	2.2	2.0	1.5	1.4
Illnesses of father: Heart disease	2.2	3.0	6.6	0.6	2.5	1.9	1.6	1.4	1.4	1.8	1.1	1.2	1.8	2.0	2.6	1.7
Breast cancer (self-reported)	2.2	2.6	5.5	0.7	1.4	1.5	2.0	2.2	2.0	1.7	1.5	-0.3	1.7	1.5	0.7	2.3
Heel T-Score	2.1	16.9	36.0	1.9	3.1	3.0	3.9	6.0	4.1	3.1	5.5	5.5	3.5	3.3	1.6	5.8
Mean time to correctly identify matches	2.1	4.1	6.9	-1.6	-2.4	-2.2	-2.1	-1.0	-2.2	-2.0	-2.6	-0.9	-2.3	-2.2	-2.3	-1.5
Alcohol intake versus 10 years previously	2.0	3.0	5.6	1.7	2.3	2.1	2.4	0.9	2.2	2.0	0.3	-0.6	2.1	2.0	1.5	0.8
Pulse wave peak to peak time	2.0	2.3	4.0	-0.4	-1.8	-1.8	-1.5	-2.0	-1.8	-1.6	-0.4	-0.8	-1.8	-2.0	-1.1	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.8	1.2	1.8	1.8	1.9	-0.5	1.7	1.2	1.7	-1.6	1.7	1.5	1.9	-0.6
Pulse wave Arterial Stiffness index	1.9	2.2	3.8	0.1	1.8	1.7	1.4	2.0	1.7	1.6	0.2	1.0	1.8	1.9	1.0	1.4
Reaction Time	1.8	3.5	5.4	-1.0	-2.3	-2.0	-1.8	-1.7	-1.9	-2.0	-1.8	-0.7	-2.2	-2.2	-2.3	-1.5
Emphysema/chronic bronchitis	1.8	2.1	5.8	-1.6	-1.0	-1.1	-0.6	-1.9	-0.5	-1.3	-1.0	-2.4	-1.0	-1.3	-1.3	-2.4
Neck or shoulder pain in last month	1.8	2.6	5.6	-0.9	-1.8	-1.4	-0.8	-2.1	-1.1	-1.6	-0.9	-2.0	-1.3	-1.7	-1.9	-2.4
Pulse rate, automated reading	1.7	5.6	10.3	1.3	2.4	2.7	2.1	3.2	2.7	2.9	1.9	1.7	2.7	2.7	1.3	2.2
Mood swings	1.7	3.1	4.9	-1.2	-2.0	-2.1	-1.7	-1.6	-1.6	-2.1	-1.1	-1.2	-1.8	-2.2	-1.6	-2.1
Eye problems/disorders: Cataract	1.7	2.0	8.1	-2.9	-1.1	-1.4	-1.1	-0.6	-1.7	-1.1	-1.9	-0.6	-1.3	-1.3	-1.1	-0.9
Alzheimer’s Disease (in mother)	1.6	1.9	3.1	1.8	1.0	1.3	1.5	1.3	1.5	1.5	1.4	0.6	1.4	1.3	1.1	1.7
Smoking Status	1.5	3.5	5.9	-2.2	-1.5	-1.7	-2.1	-2.0	-1.9	-1.7	-2.4	-0.9	-1.9	-1.8	-1.6	-2.2
Illnesses of mother	1.5	1.9	4.0	-1.7	-1.5	-1.5	-1.0	-0.5	-1.7	-1.5	-1.1	-0.1	-1.6	-1.6	-2.0	-0.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.6	-2.2	-0.8	-0.9	-0.8	-1.8	-0.6	-1.2	-0.7	-1.6	-1.2	-1.2	-1.1	-2.0
Hearing difficulty/problems: Yes	1.4	2.1	3.5	-0.5	-1.7	-1.6	-1.7	-1.0	-1.7	-1.9	-1.1	-0.9	-1.6	-1.7	-1.2	-1.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.2	-1.8	-1.3	-1.4	-1.2	-0.2	-1.5	-1.0	-1.2	0.3	-1.4	-1.4	-1.7	-0.2
Medication: Levothyroxine sodium	1.4	2.3	8.6	-2.9	-1.3	-1.6	-1.1	0.1	-1.2	-1.7	-0.3	0.1	-1.4	-1.6	-2.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.8	0.3	1.4	1.5	1.6	1.0	1.4	1.7	1.0	-0.6	1.6	1.5	1.0	1.1
Exposure to tobacco smoke at home	1.4	1.5	4.4	1.2	1.0	0.7	0.2	1.9	0.8	1.2	0.1	1.6	0.8	1.1	1.4	2.1
Headache pain in last month	1.4	2.4	4.0	-1.0	-1.0	-1.6	-1.7	-1.9	-1.2	-1.5	-1.4	-2.0	-1.6	-1.7	-1.4	-1.8
Birth weight	1.4	3.1	6.3	-2.2	-1.5	-1.7	-1.8	-1.4	-1.8	-1.3	-2.5	-1.9	-1.7	-1.7	-1.5	-1.2
Medication: Blood pressure	1.4	2.6	5.7	0.6	2.1	1.5	1.1	2.4	1.4	1.3	1.0	2.4	1.6	1.7	1.1	1.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.9	0.5	1.0	0.7	0.5	2.4	0.1	0.6	2.0	2.4	0.6	0.7	0.3	1.7
Number of incorrect matches in round	1.3	2.1	5.1	-1.5	-1.6	-1.2	-1.6	-2.3	-1.6	-1.4	-1.1	-0.4	-1.5	-1.2	-1.2	-1.6
Qualifications: A levels/AS levels or equivalent	1.3	2.8	5.3	1.5	1.7	1.5	2.0	1.4	1.7	1.7	2.3	0.1	1.8	1.6	1.9	1.7
Commuting to job workplace: Walk	1.3	1.4	3.0	0.2	-1.7	-1.7	-1.6	-0.0	-1.3	-1.5	-0.7	0.1	-1.4	-1.5	-0.7	-0.4
Qualifications: None of the above	1.2	2.7	4.5	-1.9	-2.0	-1.9	-1.8	-0.7	-1.8	-1.9	-1.3	-0.1	-1.8	-1.7	-2.1	-0.6
Prospective memory result	1.2	1.5	2.6	-1.2	-1.6	-1.3	-1.1	-1.6	-0.9	-1.4	-0.5	0.3	-1.2	-1.4	-1.6	-0.9
Osteoarthritis (self-reported)	1.2	1.5	3.1	-0.7	-1.5	-1.3	-1.6	-0.8	-1.2	-1.4	0.1	0.8	-1.3	-1.5	-1.8	-1.0
Lung FEV1/FVC ratio	1.1	5.4	15.3	-3.9	-2.0	-2.3	-1.8	-1.9	-1.8	-3.0	-0.3	0.0	-2.5	-2.8	-2.9	-2.1
Sensitivity / hurt feelings	1.1	1.9	3.6	-1.5	-1.6	-1.9	-0.9	-1.2	-0.8	-1.8	0.6	-1.2	-1.5	-1.9	-0.9	-1.3
Ever had hysterectomy (womb removed)	1.1	1.3	2.5	-1.5	-0.9	-1.1	-1.6	0.5	-1.3	-1.2	-1.6	-0.3	-1.2	-0.9	-1.2	-0.6
Pack years adult smoking proportion	1.1	1.6	3.5	0.6	1.7	1.9	1.6	-0.2	1.4	1.5	0.5	0.3	1.6	1.7	1.2	-0.1
Knee pain experienced in last month	1.1	1.7	2.5	-0.6	-1.6	-1.5	-1.5	-1.2	-1.5	-1.5	-1.1	0.1	-1.5	-1.6	-1.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.1	0.2	1.3	1.4	1.4	0.2	1.7	1.4	0.1	-1.0	1.6	1.4	0.9	0.5
Medication: Gliclazide	1.1	1.2	2.2	-0.8	-1.2	-1.3	-1.2	-0.9	-1.4	-1.3	-0.2	0.0	-1.2	-1.3	-1.5	-1.0
Current tobacco smoking	1.0	1.7	2.9	-1.4	-1.2	-1.2	-1.1	-1.7	-0.9	-1.2	-1.0	-1.4	-1.2	-1.3	-1.3	-1.6
Alcohol usually taken with meals	1.0	1.6	3.2	-1.3	-1.2	-0.9	-1.4	-0.5	-1.6	-1.1	-1.7	0.0	-1.4	-1.1	-1.8	-1.2
Forced vital capacity (FVC), Best measure	1.0	3.6	7.3	-2.7	-1.7	-2.0	-1.8	-1.2	-1.9	-2.0	-2.1	-0.7	-1.9	-2.0	-2.2	-1.7
Wheeze or whistling in the chest in last year	1.0	1.7	4.8	0.5	-1.5	-1.0	-1.1	-1.3	-1.1	-1.4	-0.5	-1.8	-1.1	-1.3	-1.2	-2.2
Number of full sisters	1.0	1.2	2.4	-0.9	-1.1	-1.3	-1.6	-0.4	-1.5	-1.4	0.0	0.8	-1.3	-1.2	-0.7	0.1
Had major operations	1.0	1.1	2.8	-1.4	-1.1	-1.1	-0.7	-0.8	-1.1	-1.7	0.1	0.2	-1.2	-1.2	-1.4	-0.8
Mother’s age at death	1.0	1.2	2.1	1.1	1.0	1.4	1.0	0.8	1.2	1.2	0.9	0.2	1.3	1.4	1.4	0.9
Average weekly beer plus cider intake	1.0	1.4	3.0	0.5	1.4	1.1	1.3	0.7	1.5	1.2	1.2	-0.7	1.5	1.2	1.7	0.5
Commuting to job workplace: Cycle	1.0	1.3	2.8	-1.0	-0.8	-1.1	-1.4	-1.1	-0.9	-1.3	-0.1	1.4	-1.3	-1.1	-0.1	-1.7
Cholesterol lowering medication	1.0	1.4	3.7	1.0	-0.4	-1.3	-1.9	1.7	-1.6	-1.0	-1.1	0.9	-1.3	-1.0	-0.4	0.9
Pack years of smoking	1.0	1.4	3.2	0.8	1.5	1.8	1.5	-0.0	1.2	1.5	0.3	0.1	1.4	1.6	1.2	-0.3
Irritable Bowel Disease (IBD)	0.9	2.2	5.0	0.5	1.5	1.3	2.0	2.2	1.3	1.6	0.4	1.7	1.6	1.4	1.3	1.4
Average weekly fortified wine intake	0.9	1.1	2.8	1.2	0.7	1.0	0.5	1.5	0.5	1.5	0.0	0.5	1.0	1.0	1.7	1.1
Asthma	0.9	1.7	3.4	0.3	-1.5	-1.7	-1.8	0.1	-1.6	-1.7	-0.8	-1.1	-1.6	-1.5	-1.1	-0.4
Qualifications: College or University degree	0.9	2.9	4.8	1.9	1.9	2.1	2.0	1.2	1.8	2.0	0.8	-0.2	2.1	1.9	2.2	0.8
Heart disease (mother)	0.9	1.1	2.7	1.6	1.4	1.2	0.9	0.6	0.9	1.0	0.6	0.2	1.2	1.2	1.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.4	0.9	0.8	1.4	1.6	-0.3	0.8	1.3	0.3	0.6	1.2	1.3	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.0	-1.6	-1.1	-1.1	-1.2	-2.0	-1.3	-1.4	-1.2	-0.9	-1.3	-1.5	-0.8	-2.0
Average weekly champagne plus white wine intake	0.9	1.2	2.4	0.6	1.1	1.5	1.4	-0.0	0.8	1.5	0.3	1.3	1.1	1.4	1.2	0.9
Ulcerative Colitis (UC)	0.8	1.5	5.2	0.6	1.4	1.1	1.5	2.3	0.8	1.1	0.8	0.6	1.2	1.2	1.1	1.4
Prostate Cancer	0.8	1.2	2.1	0.0	1.2	1.4	1.1	0.4	1.2	1.4	-0.1	-0.8	1.4	1.4	1.1	1.0
Supplements: Zinc	0.8	0.9	2.3	1.5	1.1	0.8	0.8	1.0	0.7	0.7	1.2	1.0	0.8	0.8	1.2	0.6
Severe depression (siblings)	0.8	0.9	3.8	-1.3	-0.3	-0.6	-0.4	-1.0	-0.9	-1.1	0.8	0.6	-0.7	-0.8	-0.8	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.3	1.7	1.1	0.7	0.6	0.3	1.3	0.3	1.8	-0.6	0.9	0.6	1.5	0.1
Mouth/teeth dental problems	0.8	1.2	2.6	-1.6	-0.8	-1.3	-1.0	-0.7	-1.3	-1.4	-0.1	-0.9	-1.4	-1.3	-0.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.2	-1.1	-0.9	-0.9	-1.1	-0.5	-1.5	-1.1	-0.1	-1.3	-1.3	-1.0	-1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.9	-0.0	-0.8	-0.7	-0.7	-2.2	-0.2	-1.0	-0.3	-0.2	-0.7	-0.8	-0.6	-1.9
Depression (self-reported)	0.8	1.0	4.0	-0.1	-0.2	-0.1	-0.9	-2.0	-1.1	-0.5	-0.2	-1.2	-0.7	-0.4	-0.6	-1.9
Health satisfaction	0.8	1.1	3.4	1.3	1.5	1.3	0.4	0.3	0.9	1.1	1.8	0.2	1.0	1.2	0.6	0.5
Medication: Seretide 50 evohaler	0.8	0.9	3.8	1.9	0.7	0.7	0.4	1.4	0.2	0.7	-0.3	0.4	0.6	1.0	1.4	1.0
Family relationship satisfaction	0.8	1.0	4.4	-1.2	-0.8	-0.4	-0.3	-2.0	-0.2	-0.8	0.1	-0.7	-0.6	-0.7	-0.8	-2.1
Miserableness	0.8	1.4	3.4	-0.1	-1.1	-1.4	-1.5	-0.9	-1.3	-1.9	0.7	0.5	-1.3	-1.4	-0.8	-1.3
Number of operations (self-reported)	0.8	1.2	3.3	-1.8	-0.9	-1.3	-1.2	0.4	-1.0	-1.3	-0.1	-0.5	-1.2	-1.2	-1.4	0.6
Age at First Birth	0.7	1.0	3.3	0.1	0.6	0.6	0.5	1.2	0.3	0.6	1.8	1.5	0.6	0.8	0.9	1.5
Crohns Disease (2012)	0.7	1.1	2.4	0.7	1.0	1.2	1.4	0.5	0.9	1.2	0.1	1.6	1.1	1.1	1.0	0.8
Ulcerative Colitis	0.7	1.0	2.6	-0.1	0.9	0.9	1.4	1.6	0.9	1.0	1.3	0.1	1.1	0.8	0.5	1.1
Diabetes (mother)	0.7	0.9	2.5	-0.6	-0.8	-0.8	-1.6	-0.7	-1.4	-0.8	-1.0	-0.8	-1.1	-0.9	-0.3	-1.0
Taking other prescription medications	0.7	1.2	3.5	-1.1	-1.7	-1.2	-1.1	-0.2	-0.9	-1.0	-0.5	-0.1	-1.1	-1.2	-1.9	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.5	0.6	1.3	0.8	1.0	2.1	1.2	0.7	1.7	2.1	1.0	0.9	0.7	1.2
Medication: Ramipril	0.7	0.9	3.9	0.5	0.3	0.3	0.7	1.2	0.8	0.2	1.7	2.0	0.6	0.4	0.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.7	-2.8	-1.2	-1.5	-1.0	-0.8	-1.3	-1.7	-0.9	-0.0	-1.4	-1.7	-2.0	-1.3
Tense / ‘highly strung’	0.7	1.2	3.3	1.1	1.1	1.0	1.8	0.4	1.4	1.4	-0.4	0.1	1.5	1.1	0.9	0.3
Long-standing illness, disability or infirmity	0.7	1.0	5.1	0.3	0.2	0.0	-0.1	1.9	0.2	-0.2	1.0	2.3	0.3	0.2	-0.9	1.5
Qualifications: nursing, teaching	0.7	1.0	4.5	-0.4	-0.8	-0.4	-0.9	-2.1	-1.0	-0.7	-0.5	-0.8	-0.9	-0.5	-0.7	-1.9
Asthma (self-reported)	0.7	1.3	2.4	0.4	-1.3	-1.5	-1.6	0.1	-1.4	-1.3	-0.7	-1.5	-1.3	-1.3	-0.9	-0.4
Smoking status: Current	0.7	1.2	2.2	-1.5	-0.9	-1.0	-0.9	-1.3	-0.8	-1.0	-1.1	-1.0	-1.0	-1.1	-0.9	-1.2
Coronary Artery Disease (CAD)	0.6	0.8	2.2	-1.5	-0.5	-0.9	-0.4	-0.7	-0.8	-0.8	-1.2	0.1	-0.9	-1.0	-1.0	-0.9
Angina	0.6	0.7	2.0	1.4	0.5	0.6	-0.2	1.3	0.7	0.6	0.1	1.3	0.6	0.8	0.9	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.8	0.3	0.5	0.8	0.4	1.9	0.9	0.5	1.2	0.3	0.7	0.7	0.3	1.0
Pain all over the body in last month	0.6	0.7	1.7	0.2	1.0	0.8	1.0	0.3	1.3	0.9	0.2	-0.6	1.1	0.8	0.9	0.5
Fluid intelligence score	0.6	1.2	2.3	1.3	1.1	1.5	1.0	0.9	1.3	1.4	0.8	-0.1	1.3	1.4	0.8	0.1
Illnesses of siblings	0.6	0.9	1.9	-0.0	1.3	0.9	1.2	0.8	1.4	0.8	0.9	0.2	1.0	0.9	0.7	0.9
Impedance of arm (right)	0.6	2.8	6.5	-0.2	1.5	1.7	2.3	1.2	2.5	2.3	0.4	0.4	2.2	1.8	1.0	1.7
Time employed in main current job	0.6	0.7	3.2	-0.4	0.8	0.4	1.0	0.6	1.0	0.4	-0.3	-1.8	0.9	0.6	0.5	0.9
Worrier / anxious feelings	0.6	1.2	3.3	-1.2	-1.0	-0.7	-0.3	-1.6	-0.0	-0.8	-0.5	-1.7	-0.5	-1.0	-1.0	-1.8
Impedance of arm (left)	0.6	2.6	5.3	-0.5	1.3	1.5	2.2	1.8	2.3	2.1	0.7	0.2	2.1	1.7	0.6	2.2
Arm fat-free mass (right)	0.6	3.1	7.2	-0.9	-1.0	-1.8	-2.7	-0.9	-2.4	-2.0	-1.7	1.7	-2.1	-1.5	-2.0	-1.0
Angina (self-reported)	0.6	0.8	2.3	1.5	0.6	0.6	-0.2	1.4	0.8	0.6	0.1	1.5	0.6	0.8	1.0	0.8
Medication: Omeprazole	0.6	0.7	2.2	0.5	-1.0	-0.2	-0.8	-0.9	-0.0	-0.3	-1.5	-1.4	-0.3	-0.3	-0.6	-1.3
Arm predicted mass (right)	0.6	2.8	6.9	-0.7	-0.9	-1.6	-2.6	-0.9	-2.3	-1.9	-1.5	1.6	-2.0	-1.4	-1.9	-1.2
Illnesses of father: None of the above (group 1)	0.6	0.8	2.3	-0.3	-1.1	-1.0	-0.7	-0.9	-0.9	-0.8	-0.8	0.3	-0.9	-0.9	-1.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.6	0.9	1.1	1.2	0.8	0.5	0.6	1.0	0.6	0.5	1.1	1.1	0.7	0.4
High cholesterol (Self-reported)	0.6	1.0	5.0	1.5	0.8	0.3	-0.2	2.2	0.6	0.5	0.6	0.8	0.4	0.4	-0.0	1.8
Ever smoked	0.6	1.0	4.2	-0.4	-0.5	-0.4	-0.4	-2.0	-0.9	-0.5	-1.5	0.4	-0.9	-0.6	-1.0	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.2	0.5	-1.5	-0.7	-1.1	-0.3	-0.5	-0.7	-1.1	-1.1	-0.7	-0.8	-0.7	-0.9
Cardiovascular Disease	0.5	1.8	4.1	0.5	1.7	0.8	1.1	2.0	1.1	1.0	1.5	1.7	1.1	1.0	0.1	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.0	-0.1	1.1	0.7	1.1	2.0	0.9	0.6	1.2	1.7	0.8	0.8	-0.0	1.5
Nervous feelings	0.5	0.9	4.6	-2.1	0.3	0.4	1.3	-0.0	0.9	0.2	1.0	-1.2	0.6	0.1	-0.7	-1.0
Diabetes (self-reported)	0.5	0.7	3.8	-0.1	0.3	-0.0	0.0	2.0	-0.1	0.1	0.8	1.7	0.2	0.2	-0.3	1.3
Father’s age at death	0.5	0.7	7.5	0.1	-0.1	-0.1	0.1	0.2	-0.1	0.1	-0.8	-2.7	0.2	0.0	0.8	-0.3
Gout (self-reported)	0.5	0.6	1.7	0.4	0.6	0.7	1.0	0.2	1.3	0.8	0.9	-0.6	0.9	0.7	0.6	0.8
Age at first live birth	0.5	0.8	3.6	0.4	0.9	0.9	0.6	1.9	0.3	0.9	0.7	-0.0	0.7	0.9	1.0	1.1
Age at last live birth	0.5	0.7	2.0	-0.3	1.2	0.9	0.9	0.9	0.5	0.8	1.4	0.4	0.7	0.8	0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-1.0	-1.0	-0.8	-0.5	-0.1	-0.9	-0.8	-0.5	-0.6	-0.9	-0.9	-1.1	-0.6
Supplements: Vitamin C	0.5	0.6	2.3	1.5	0.3	-0.2	-0.8	0.9	-0.6	0.0	-0.5	1.2	-0.3	-0.1	1.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.9	-1.5	-0.3	-0.6	-0.8	-1.0	-0.5	-1.0	0.4	-0.2	-0.7	-0.8	-2.0	-1.6
Medication for cholesterol	0.5	0.7	5.2	-0.4	-0.8	-0.1	0.1	-2.3	-0.0	-0.0	-0.6	-0.9	-0.3	-0.4	0.2	-1.4
Back pain experienced in last month	0.5	0.8	3.9	-2.0	-0.3	-0.4	0.0	-1.8	-0.3	-0.3	-1.2	-0.2	-0.3	-0.4	-0.9	-0.5
Arm fat-free mass (left)	0.5	2.4	5.7	-0.4	-0.6	-1.4	-2.4	-0.9	-1.8	-1.7	-1.3	2.4	-1.8	-1.2	-1.7	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-0.3	1.1	0.8	1.0	0.6	1.2	0.7	0.4	0.1	1.0	0.7	0.4	0.7
Diastolic blood pressure, automated reading	0.5	1.6	3.4	0.6	1.9	1.5	1.2	0.3	0.8	1.3	0.9	1.7	1.0	1.5	1.3	1.4
Heart disease (siblings)	0.5	0.6	1.7	0.8	0.3	1.0	1.0	0.7	0.4	0.9	1.3	-0.1	0.8	0.8	-0.2	0.5
Bipolar Disorder or Schizophrenia	0.4	0.9	2.4	1.2	0.7	0.4	0.3	1.5	0.1	0.4	1.2	-0.3	0.4	0.5	1.5	1.5
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	0.7	-1.0	-1.2	-0.8	-0.9	-0.9	-1.1	0.6	-0.5	-0.9	-1.2	-0.1	-0.8
Crohns Disease (2017)	0.4	0.9	3.2	-0.2	0.8	0.7	1.4	1.1	0.7	1.0	-0.5	1.8	0.9	0.8	0.6	0.8
Major Depression (MDD)	0.4	0.5	1.9	0.9	1.0	0.6	0.2	0.2	0.0	0.4	1.1	0.0	0.5	0.6	1.4	-0.1
Rheumatoid Arthritis	0.4	0.6	1.6	0.2	0.6	0.4	0.1	1.3	0.0	0.3	0.9	0.7	0.4	0.6	1.2	1.3
Respiratory disease	0.4	0.9	4.6	0.3	-0.9	-0.9	-1.0	0.3	-1.0	-0.8	-0.8	-2.2	-0.9	-0.7	-0.5	-0.3
Lung FVC	0.4	2.0	4.5	-1.3	-2.1	-1.7	-1.7	0.2	-2.1	-1.4	-1.0	-0.5	-1.6	-1.6	-1.0	-0.0
Chronotype (morning person)	0.4	0.8	2.4	-1.2	-1.4	-0.9	-0.5	0.0	-0.6	-1.2	-0.5	-0.5	-0.9	-0.9	-1.5	0.4
Medication: Metformin	0.4	0.6	2.7	0.2	0.2	0.1	-0.3	1.6	0.2	0.1	0.2	1.6	0.2	0.3	-0.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	-0.6	-0.5	-0.5	-0.7	-0.3	-0.4	-0.9	0.1	-0.3	-0.6	-0.6	-1.0	-1.2
High blood pressure	0.4	1.0	2.1	-0.7	1.2	1.0	1.1	0.9	1.2	0.7	0.7	1.4	1.1	1.0	-0.2	1.1
Multivitamins +/- minerals	0.4	0.5	1.4	-0.0	-0.4	-0.9	-1.0	-0.6	-1.2	-0.8	-0.3	0.1	-1.0	-0.8	-0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.3	1.0	0.9	0.5	0.3	-0.6	0.9	0.1	1.8	-0.1	0.7	0.3	0.9	-0.3
Had other major operations	0.4	0.4	2.7	-0.0	-0.4	-0.5	-0.5	1.6	-0.0	-0.2	0.1	-0.2	-0.2	-0.3	-0.6	1.3
Forced vital capacity (FVC)	0.4	1.6	4.1	-2.0	-1.1	-1.4	-1.1	-0.7	-1.4	-1.3	-1.4	-0.3	-1.3	-1.4	-1.4	-0.7
Arm fat percentage (right)	0.4	1.4	5.8	1.6	0.8	0.8	0.0	0.7	1.0	1.1	1.1	2.4	0.7	0.9	0.9	1.7
Number of live births	0.4	0.5	1.8	-0.2	0.9	0.6	0.6	0.9	0.3	0.8	-0.3	0.3	0.6	0.8	0.5	1.4
Standing height	0.4	3.9	12.6	-3.5	-0.4	-1.8	-1.9	-0.6	-1.4	-1.5	-3.3	1.6	-1.5	-1.2	-3.0	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.6	2.3	-0.2	1.0	0.7	1.1	0.9	0.4	0.4	1.5	0.7	0.7	0.6	0.7	0.5
Medication: Ibuprofen	0.4	0.5	3.2	0.1	-0.5	-0.4	-0.5	-1.8	-0.2	-0.6	-0.5	-0.2	-0.5	-0.5	-0.4	-1.3
Chest pain or discomfort	0.4	0.6	3.0	0.0	-0.5	-0.4	-0.4	0.1	-0.5	-0.5	-1.1	-1.7	-0.3	-0.5	-0.8	-1.0
Leg pain on walking	0.4	0.5	2.4	1.5	-0.1	0.1	-0.1	1.3	-0.3	0.2	0.2	0.5	0.1	0.2	-0.4	1.3
Ever had bowel cancer screening	0.4	0.5	1.0	-0.2	0.7	0.8	0.9	1.0	0.7	1.0	0.3	0.6	0.8	0.8	0.8	0.2
Medication: Bendroflumethiazide	0.4	0.7	1.5	-1.2	-0.5	-0.8	-1.1	0.9	-1.2	-0.6	-0.9	0.8	-0.7	-0.5	-0.4	0.6
Medication: Atorvastatin	0.4	0.5	2.1	1.4	-0.2	-0.6	-0.7	0.5	-0.6	-0.3	-0.3	1.5	-0.4	-0.5	-0.0	0.1
Alcohol drinker status: Never	0.4	0.5	1.3	0.3	0.4	0.6	0.8	0.4	0.9	0.3	1.2	-0.1	0.7	0.6	1.0	0.4
Ever depressed for a whole week	0.4	0.5	3.8	-0.2	0.6	0.6	0.1	-0.5	0.3	0.2	1.1	1.9	0.3	0.5	0.0	-0.2
Supplements: Calcium	0.4	0.4	1.5	0.5	1.1	0.5	0.4	0.5	0.2	0.5	0.2	-0.7	0.4	0.7	1.2	0.5
Arm predicted mass (left)	0.4	1.9	5.5	-0.2	-0.3	-1.2	-2.2	-0.7	-1.6	-1.4	-1.2	2.3	-1.5	-0.9	-1.5	-0.8
Bipolar Disorder (2018)	0.3	0.5	2.0	0.1	0.3	0.3	0.7	1.1	0.6	0.7	0.7	0.2	0.5	0.3	0.9	1.4
Schizophrenia (2018)	0.3	0.5	2.0	1.4	0.7	0.3	-0.2	1.1	-0.3	0.0	1.0	-0.3	0.1	0.4	1.2	0.8
Worry (Nagel 2018)	0.3	0.5	1.5	-0.9	0.4	0.4	1.2	0.8	1.0	0.6	0.1	-1.2	0.8	0.4	0.2	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.5	-0.6	-0.8	-1.1	0.2	-0.9	-0.8	-0.7	0.2	-0.7	-0.8	-0.1	-0.2
HDL Cholesterol	0.3	0.5	2.0	-0.7	-0.9	-0.5	-0.2	0.0	-0.5	-0.5	0.6	0.7	-0.6	-0.6	-1.4	-0.6
Lupus	0.3	0.5	1.2	-0.3	0.4	0.8	0.9	0.9	1.1	1.0	-0.0	-0.0	0.9	0.8	0.8	0.3
Neuroticism (2016)	0.3	0.5	2.3	1.0	-0.2	0.0	0.0	-1.0	0.3	-0.2	1.1	0.3	-0.1	-0.4	0.3	-1.5
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.1	-0.9	-0.7	-0.5	0.2	-0.7	-1.2	0.9	-0.1	-0.6	-0.8	-0.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.7	-0.1	-0.6	-0.4	-0.2	-0.4	-0.3	-0.5	-0.3	-1.0	-0.4	-0.5	-1.3	-0.6
Blood White Count	0.3	2.2	8.9	-0.3	1.2	0.6	0.8	2.0	1.3	0.9	1.3	3.0	1.0	1.0	1.5	2.1
Height	0.3	5.1	28.2	-5.3	0.1	-1.2	-1.1	-0.9	-0.6	-1.1	-3.6	1.2	-0.9	-0.7	-3.5	-2.3
Hypothyroidism (self reported)	0.3	0.8	3.6	-1.9	-0.5	-0.6	-0.6	0.6	-0.5	-0.7	-0.4	-0.1	-0.7	-0.6	-1.8	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	3.0	0.1	0.1	-0.4	-0.4	1.7	-0.4	-0.2	0.3	1.7	-0.3	-0.3	-0.3	0.3
Medication for hormone replacement therapy	0.3	0.4	1.3	-0.8	-0.4	-0.1	0.4	-0.8	-0.0	-0.2	0.4	-1.1	-0.0	-0.4	-0.7	-1.0
Leg fat-free mass (left)	0.3	1.3	4.7	-0.0	-0.5	-1.2	-2.2	-0.3	-1.5	-1.3	-0.7	1.6	-1.4	-1.0	-1.0	-0.2
Trunk fat percentage	0.3	1.1	10.0	0.7	0.1	0.1	-0.5	1.1	0.4	0.3	0.5	3.2	0.1	0.3	-0.5	1.4
Hand grip strength (right)	0.3	0.9	2.5	0.7	1.6	0.6	1.2	1.5	0.3	0.8	1.0	0.3	0.7	0.9	0.7	1.1
Townsend deprivation index at recruitment	0.3	0.4	1.5	-1.2	-0.2	-0.5	-0.0	-0.3	-0.2	-0.9	-0.2	-0.3	-0.5	-0.4	-1.2	-0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	1.5	-0.8	0.4	0.2	0.5	1.2	0.4	0.5	-0.5	0.9	0.5	0.2	-0.0	1.0
High blood pressure (mother)	0.3	0.4	1.3	0.1	0.2	0.1	0.3	-1.1	0.6	0.0	-0.6	-0.9	0.4	0.2	1.1	-1.0
Past tobacco smoking	0.3	0.6	2.1	0.1	0.3	0.4	0.8	1.5	0.9	0.4	0.7	-0.3	0.8	0.5	0.9	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	-1.2	-0.1	0.1	0.8	-1.3	0.6	0.4	0.0	-0.8	0.2	-0.1	-0.5	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.0	0.5	0.5	0.6	0.0	-0.6	0.4	0.5	0.8	1.4	0.4	0.4	0.7	-0.3
Financial difficulties in last 2 years	0.3	0.4	1.3	0.7	-0.4	-0.8	-1.0	-0.0	-0.0	-0.9	0.4	-1.1	-0.5	-0.7	0.1	-0.0
Heart attack	0.3	0.4	1.6	1.3	-0.8	-0.4	-1.2	0.5	0.2	-0.5	0.2	-0.2	-0.4	-0.5	-0.3	-0.6
Medication: Simvastatin	0.3	0.5	2.9	0.8	0.1	0.1	-0.5	1.7	0.4	0.2	0.4	-0.5	0.3	0.2	0.1	1.4
Weight	0.3	1.4	7.2	-0.3	-0.4	-1.0	-2.0	-0.2	-1.1	-1.0	-0.7	2.7	-1.2	-0.8	-1.2	-0.0
Hip circumference	0.3	1.2	10.8	0.4	-0.4	-0.5	-1.4	-0.1	-0.6	-0.5	0.4	3.3	-0.8	-0.5	-0.6	0.1
Happiness	0.3	0.3	1.8	-0.4	0.5	0.2	0.3	-0.5	0.7	-0.1	1.4	0.7	0.4	0.2	0.5	-0.4
Noisy workplace	0.3	0.4	1.1	1.0	-0.4	-0.4	-0.8	-0.3	-0.9	-0.7	-0.1	-0.4	-0.5	-0.4	-0.4	-1.1
Breastfed as a baby	0.3	0.3	0.6	-0.6	-0.8	-0.7	-0.7	0.4	-0.8	-0.5	-0.0	0.3	-0.6	-0.5	-0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.2	-1.0	-0.4	-0.2	-0.5	-1.1	-0.4	-0.6	0.3	-0.6	-0.5	-0.4	-0.7	-1.5
Blood clot in the leg (DVT)	0.3	0.4	1.9	-0.4	-0.3	-0.2	-0.5	-1.4	-0.4	-0.4	-0.9	0.6	-0.2	-0.3	-0.9	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.4	-0.4	-0.1	-0.4	-0.3	-1.2	-1.1	-0.4	-1.2	-0.5	-0.6	-0.4	0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	4.0	-2.0	-0.4	-0.5	0.1	1.0	-0.1	-0.7	0.3	0.7	-0.4	-0.6	-1.4	0.3
Body fat percentage	0.3	1.0	8.7	0.8	0.1	0.1	-0.6	0.9	0.4	0.3	0.5	2.9	0.0	0.3	-0.3	1.3
Worry too long after embarrassment	0.3	0.4	1.9	-0.8	-0.8	-0.4	-0.1	-0.1	-0.2	-0.8	0.8	0.3	-0.4	-0.6	-1.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.7	-0.2	-0.6	-0.3	-0.6	-0.6	-0.9	-0.5	-1.0	-0.7	-0.5	0.2	-0.2
Medication: Blood pressure	0.3	0.5	2.0	-0.5	-0.0	0.1	0.1	1.0	0.5	0.1	1.4	0.8	0.3	0.2	-0.6	1.2
Alcohol intake frequency.	0.3	0.7	1.7	-0.3	-0.6	-0.9	-0.9	0.0	-0.6	-1.3	-0.6	-0.1	-1.0	-1.0	-1.2	-1.1
Suffer from ‘nerves’	0.3	0.5	1.9	-1.4	0.1	-0.2	1.0	0.9	0.8	0.2	1.0	-0.2	0.4	-0.1	-0.2	0.5
Overall health rating	0.3	0.6	3.5	0.5	0.5	0.8	0.7	0.1	1.2	0.5	1.9	0.3	0.8	0.6	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-1.2	-0.1	0.2	0.5	-0.3	0.1	0.0	-0.0	-0.5	0.1	-0.0	-1.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	3.3	1.8	0.5	0.3	0.5	-0.2	-0.3	0.4	-0.3	0.2	0.3	0.5	0.9	0.1
Hypertension (Self-reported)	0.3	0.9	1.4	-0.8	1.2	1.1	1.1	0.9	1.2	0.8	0.6	1.1	1.1	1.1	-0.2	1.0
Illnesses of siblings: Diabetes	0.3	0.3	2.1	1.4	-0.1	-0.2	-0.7	0.1	-0.3	-0.1	0.3	0.6	-0.1	-0.2	1.0	-0.2
Smoking status: Previous	0.3	0.4	1.8	0.1	-0.1	-0.2	-0.5	-1.4	-0.7	-0.2	-0.7	-0.1	-0.6	-0.3	-0.7	-1.1
Whole body fat-free mass	0.3	1.5	4.1	-0.3	-0.3	-1.1	-2.0	-0.7	-1.6	-1.3	-1.1	1.7	-1.4	-0.9	-1.3	-0.6
Leg fat-free mass (right)	0.3	1.5	5.2	-0.1	-0.5	-1.3	-2.3	-0.5	-1.7	-1.4	-0.7	1.6	-1.5	-1.1	-1.1	-0.4
Diabetes diagnosed by doctor	0.3	0.4	1.4	0.0	-0.3	-0.7	-0.8	1.2	-0.5	-0.6	0.3	1.0	-0.4	-0.5	-0.8	0.4
Osteoporosis (self-reported)	0.3	0.3	1.5	1.2	-0.2	0.2	0.2	0.9	-0.1	0.3	0.5	-0.6	0.2	0.3	0.9	0.6
Whole body water mass	0.3	1.5	4.2	-0.3	-0.3	-1.2	-2.1	-0.6	-1.6	-1.4	-1.2	1.7	-1.4	-0.9	-1.3	-0.6
Number of self-reported non-cancer illnesses	0.3	0.6	2.8	-1.5	-0.7	-0.4	-0.6	0.3	-0.2	-0.4	-0.5	0.6	-0.4	-0.4	-1.7	0.3
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.9	-0.1	-0.6	-1.1	0.1	-0.2	-0.6	-0.7	-0.4	-0.5	-0.5	0.6	-0.1
Financial situation satisfaction	0.3	0.3	1.7	0.1	0.5	-0.2	-0.6	0.9	0.1	0.0	0.5	-0.2	-0.1	0.0	1.3	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	-0.8	-0.5	-0.5	-0.2	-1.1	-0.6	-0.5	-0.6	-0.1	-0.5	-0.5	-0.4	-0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	4.1	-0.6	-0.3	0.3	-0.1	0.2	-0.1	-0.1	0.5	-2.0	0.1	0.1	-0.6	-0.2
Basal metabolic rate	0.3	1.5	4.3	-0.3	-0.4	-1.1	-2.1	-0.6	-1.5	-1.3	-1.0	2.0	-1.4	-0.9	-1.3	-0.5
Irritability	0.3	0.5	1.4	-0.3	0.6	0.6	1.2	0.6	0.7	0.8	0.8	-0.0	1.0	0.7	0.2	1.1
Fractured/broken bones in last 5 years	0.3	0.4	2.9	-0.3	0.3	-0.1	-0.0	-0.5	-0.6	0.1	-1.7	-1.0	-0.3	0.0	0.3	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.6	-0.3	-0.5	-0.1	0.1	-1.3	0.2	-0.4	-0.5	-0.8	0.1	-0.3	-0.9	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.1	1.4	-0.7	-0.4	-1.2	0.5	0.2	-0.5	0.3	-0.2	-0.4	-0.5	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.4	-0.6	-0.3	-0.2	-0.5	-1.2	-0.4	-0.4	-0.9	0.3	-0.3	-0.3	-1.0	0.0
Alcohol drinker status: Previous	0.3	0.4	1.1	-0.8	-0.1	-0.4	-0.7	0.3	-0.8	-0.4	-0.5	1.0	-0.7	-0.5	-0.3	-0.4
Impedance of whole body	0.3	1.3	3.5	-1.2	0.7	0.9	1.8	1.1	1.9	1.4	-0.0	0.3	1.4	1.0	-0.3	1.2
Leg fat mass (left)	0.3	1.0	6.4	0.4	-0.6	-0.7	-1.6	0.1	-0.8	-0.6	-0.3	2.5	-1.0	-0.5	-0.8	0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.7	-0.9	-0.5	-0.4	-0.5	-0.3	-0.1	-0.1	-0.4	-0.5	-0.7	-1.0	0.7
Bipolar Disorder (2011)	0.2	0.2	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	1.4
Mean Putamen Volume	0.2	0.3	0.9	-0.9	-0.3	0.1	0.4	-1.0	0.3	-0.1	-0.5	-0.3	0.1	-0.1	-0.6	-0.7
Fasting Glucose	0.2	0.3	0.8	0.2	0.8	0.3	0.3	-0.1	0.2	-0.2	0.6	0.5	0.3	0.4	0.7	-0.9
HbA1C	0.2	0.3	0.8	0.9	-0.2	-0.1	-0.9	0.9	-0.2	0.1	0.2	0.5	-0.0	0.1	0.0	0.9
BMI	0.2	1.1	3.3	1.7	-0.5	-0.9	-1.8	0.3	-1.3	-1.0	0.4	1.2	-1.2	-0.8	-0.3	0.1
Waist Hip Ratio (WHR)	0.2	1.0	3.5	-0.3	-1.0	-0.9	-0.7	-0.0	-0.9	-0.7	-1.6	-1.9	-0.7	-0.7	-1.5	0.2
Allergy or Eczema	0.2	0.4	2.4	-0.5	0.0	-0.0	0.4	1.6	-0.3	0.1	0.8	0.4	-0.0	0.3	-0.4	1.1
Number of treatments/medications taken	0.2	0.3	1.7	0.4	0.5	0.6	0.3	1.3	0.6	0.7	-0.2	0.2	0.5	0.6	-0.1	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.7	0.0	-0.0	-0.0	0.1	-0.9	0.4	-0.3	1.3	0.4	0.2	-0.1	0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	2.0	-0.4	-0.2	-0.2	0.0	0.4	-0.4	0.1	-1.4	0.2	-0.0	-0.0	-0.3	0.4
Vitamin and mineral supplements	0.2	0.2	0.8	-0.8	-0.2	0.5	0.8	0.1	0.9	0.2	0.3	0.0	0.6	0.4	-0.3	-0.2
Medication: Co-codamol	0.2	0.2	0.7	-0.5	-0.5	-0.5	-0.4	-0.5	-0.5	-0.4	-0.1	0.8	-0.5	-0.4	-0.4	-0.3
Diabetes (father)	0.2	0.2	0.6	-0.1	-0.7	-0.3	-0.5	0.3	-0.1	-0.8	0.7	-0.2	-0.2	-0.5	-0.4	-0.6
Fed-up feelings	0.2	0.4	1.6	1.3	-0.1	-0.0	0.1	0.3	0.5	0.1	1.3	-0.7	0.2	-0.1	0.9	0.2
Age when periods started (menarche)	0.2	0.4	0.7	0.6	0.8	-0.1	-0.7	0.6	-0.1	-0.6	-0.8	-0.7	-0.2	0.1	0.7	-0.8
Qualifications: CSEs or equivalent	0.2	0.2	1.2	1.1	0.2	0.0	-0.5	-0.2	0.7	-0.3	0.6	0.4	0.1	0.1	0.7	-0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.2	0.1	0.8	0.5	0.2	0.7	0.5	0.9	-0.7	0.5	0.4	-0.4	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.7	-0.5	0.7	0.3	0.6	0.8	0.0	0.4	1.3	0.2	0.2	0.4	0.1	0.6
Stomach or abdominal pain in last month	0.2	0.3	1.5	1.2	0.1	0.1	0.4	0.4	0.0	0.0	0.8	0.4	0.3	0.2	0.4	0.7
Body mass index (BMI)	0.2	0.7	4.3	1.3	-0.3	-0.3	-1.2	0.1	-0.6	-0.4	0.7	2.1	-0.6	-0.3	0.1	0.6
Leg predicted mass (left)	0.2	1.2	4.2	0.0	-0.4	-1.1	-2.1	-0.2	-1.4	-1.2	-0.7	1.5	-1.3	-0.9	-0.9	-0.2
Trunk fat mass	0.2	1.1	8.9	0.1	-0.2	-0.5	-1.2	0.6	-0.3	-0.3	-0.3	3.0	-0.6	-0.2	-1.1	0.9
Waist circumference	0.2	0.8	4.0	0.9	-0.6	-0.6	-1.5	0.0	-0.9	-0.6	0.1	2.0	-0.9	-0.5	-0.7	0.5
Had menopause	0.2	0.3	2.3	0.1	-0.0	0.0	-0.2	0.3	-0.1	0.3	-1.2	-1.5	-0.0	0.1	-0.4	-0.1
Allergy	0.2	0.4	0.9	0.8	0.2	0.8	0.5	-0.2	0.9	0.8	0.0	0.5	0.8	0.6	0.7	-0.1
Neuroticism score	0.2	0.4	1.2	-0.8	-0.7	-0.7	0.1	-0.3	0.0	-0.9	0.6	-0.5	-0.3	-0.9	-0.5	-1.1
Trunk fat-free mass	0.2	1.3	3.0	-0.5	-0.2	-1.0	-1.7	-0.9	-1.4	-1.2	-1.3	1.4	-1.2	-0.8	-1.3	-0.8
Falls in the last year	0.2	0.3	0.8	-0.4	-0.7	-0.2	-0.5	-0.9	-0.5	-0.3	-0.5	-0.8	-0.5	-0.5	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	3.4	-1.9	-0.4	-0.8	-0.3	-0.4	-0.6	-1.0	-0.3	0.4	-0.7	-0.9	-1.1	-0.3
Arm fat mass (right)	0.2	0.9	7.7	1.3	0.4	0.2	-0.8	0.5	0.2	0.3	0.4	2.8	-0.0	0.4	0.2	1.2
Trunk predicted mass	0.2	1.3	3.0	-0.5	-0.2	-1.0	-1.7	-0.8	-1.4	-1.1	-1.3	1.5	-1.2	-0.8	-1.3	-0.8
Length of working week for main job	0.2	0.3	2.7	0.3	-0.0	-0.3	0.0	-0.4	-0.4	-0.2	0.4	1.6	-0.3	-0.2	-0.1	-0.2
Peak expiratory flow (PEF)	0.2	0.5	1.9	-1.4	0.1	-0.8	-0.1	-0.3	-0.9	-0.9	-0.4	0.5	-0.7	-0.7	-0.7	-0.4
Loud music exposure frequency	0.2	0.2	0.9	1.0	0.5	0.4	-0.3	0.2	0.2	0.1	0.2	-0.7	0.4	0.5	0.7	0.3
Medication: Paracetamol	0.2	0.4	0.9	-0.5	-0.7	-0.5	-0.4	-0.7	-0.7	-0.4	-1.0	-0.7	-0.7	-0.4	-0.8	-0.1
Medication: Amlodipine	0.2	0.2	0.5	0.6	0.4	0.7	0.5	0.7	0.6	0.3	0.5	0.4	0.5	0.5	0.1	-0.1
High blood pressure (siblings)	0.2	0.4	1.2	-0.6	-0.3	-0.3	-0.5	-1.1	-0.7	-0.3	-0.8	1.0	-0.4	-0.3	-0.2	-0.3
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.2	-0.2	-0.4	-0.2	0.3	-1.1	-0.4	-0.9	0.6	-0.6	-0.4	-0.7	-0.3
Comparative body size at age 10	0.2	0.6	3.5	1.9	0.6	0.3	-0.3	-0.6	-0.1	0.4	0.6	-0.2	-0.1	0.3	1.7	-0.2
Whole body fat mass	0.2	0.9	7.4	0.3	-0.2	-0.4	-1.2	0.6	-0.3	-0.2	-0.2	2.7	-0.5	-0.2	-0.7	0.9
Leg fat mass (right)	0.2	0.8	5.6	0.4	-0.4	-0.6	-1.4	0.2	-0.6	-0.5	-0.2	2.4	-0.8	-0.4	-0.6	0.5
Comparative height size at age 10	0.2	1.4	6.3	-2.1	-0.2	-0.4	-0.4	0.4	-0.9	-0.0	-2.1	1.0	-0.4	-0.1	-2.5	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.6	-0.1	0.5	0.5	0.2	-0.4	0.6	0.5	-0.2	-0.4	0.5	0.5	1.3	-0.2
Arm fat percentage (left)	0.2	1.0	4.7	1.4	0.3	0.4	-0.4	0.7	0.6	0.7	0.8	2.2	0.3	0.6	0.5	1.7
Loneliness, isolation	0.2	0.2	1.3	0.5	-0.1	0.1	0.3	-0.8	0.0	-0.3	1.1	-0.2	0.1	-0.0	0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	0.3	-0.6	-0.8	-0.6	-0.3	-0.7	-0.7	0.3	-1.0	-0.5	-0.7	-0.4	-0.4
Leg predicted mass (right)	0.2	1.3	4.5	-0.0	-0.4	-1.1	-2.1	-0.3	-1.6	-1.2	-0.7	1.7	-1.4	-0.9	-1.1	-0.2
Arm fat mass (left)	0.2	0.8	6.3	1.0	0.2	-0.1	-1.0	0.5	-0.1	0.1	0.2	2.5	-0.3	0.1	-0.1	1.1
Guilty feelings	0.2	0.2	1.6	-0.1	-0.2	-0.0	0.0	-0.8	0.3	-0.3	0.6	0.3	0.1	-0.3	0.2	-1.2
Commuting to job workplace: Public transport	0.2	0.3	1.2	0.4	-0.1	-0.4	-0.9	-0.1	-0.7	-0.4	-1.1	0.3	-0.5	-0.2	0.2	0.3
Medication: Lisinopril	0.2	0.2	1.0	-0.2	-0.3	-0.1	-0.7	0.6	-0.1	0.0	-0.8	0.2	0.1	0.2	-0.6	1.0
Leg fat percentage (left)	0.2	0.8	6.7	0.5	-0.5	-0.5	-1.1	0.1	-0.4	-0.3	-0.1	2.6	-0.7	-0.4	-0.7	0.4
Risk taking	0.2	0.3	1.0	1.0	0.2	0.3	-0.0	0.8	-0.7	0.5	-0.8	-0.7	0.1	0.4	0.1	0.7
Unable to work because of sickness or disability	0.2	0.3	1.4	0.1	-0.5	-0.5	-0.5	-0.3	-0.1	-0.8	-0.1	-0.4	-0.5	-0.6	-1.2	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.8	0.3	-0.6	-0.6	-0.4	-1.0	-0.8	-0.3	-0.1	-1.3	-0.6	-0.6	0.4	-0.6
Depression (Nagel 2018)	0.1	0.2	0.6	0.2	-0.1	-0.2	-0.1	-0.7	0.2	-0.4	0.7	-0.3	-0.1	-0.3	0.6	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.4	-0.6	-0.8	0.0	0.1	-0.3	-0.6	0.6	-0.5	-0.3	-0.7	-0.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.0	-0.3	-0.2	0.1	-0.2	-0.1	0.3	0.1	-0.2	-0.2	0.0	-0.1	-0.7	-1.0
Ovarian Cancer	0.1	0.1	0.3	0.3	-0.3	0.4	0.2	-0.1	0.6	0.5	-0.3	0.2	0.3	0.1	0.2	-0.0
LDL Cholesterol	0.1	0.2	1.6	0.4	1.3	0.4	0.0	0.0	0.1	0.2	0.7	-0.2	0.1	0.3	0.4	-0.2
Schizophrenia (2014)	0.1	0.2	0.7	-0.5	-0.0	-0.4	-0.7	0.3	-0.8	-0.3	0.2	-0.3	-0.5	-0.3	0.3	0.8
Triglycerides	0.1	0.1	0.5	0.5	0.0	-0.4	-0.7	-0.0	-0.3	-0.3	-0.2	-0.5	-0.3	-0.2	0.3	0.1
Blood Eosinophil Count	0.1	1.0	2.7	-0.8	-1.6	-1.1	-1.0	-0.5	-1.2	-1.3	-0.5	-0.0	-1.2	-0.9	-0.8	-0.8
Systolic Blood Pressure	0.1	0.5	1.7	0.2	1.0	0.5	0.8	0.4	0.2	0.5	-0.0	1.3	0.7	0.7	0.7	1.0
Neuroticism	0.1	0.2	1.1	-0.6	0.1	-0.3	0.7	0.4	0.2	-0.2	0.6	-1.0	0.2	-0.2	-0.3	-0.3
Tanning	0.1	0.7	2.3	1.0	0.4	0.4	0.5	0.7	-0.0	-0.8	-1.5	1.5	0.3	0.4	0.4	1.2
Systolic blood pressure, automated reading	0.1	0.4	1.9	0.1	0.7	0.5	0.4	0.2	-0.3	0.6	-0.6	1.4	0.3	0.7	0.7	0.8
Impedance of leg (right)	0.1	0.7	2.5	-1.6	0.3	0.4	1.6	0.2	1.4	0.7	-0.6	-0.2	0.9	0.6	-0.6	0.1
Supplements: Glucosamine	0.1	0.1	0.4	-0.3	-0.3	-0.0	0.2	-0.1	-0.4	0.1	0.4	-0.5	-0.1	-0.1	-0.6	-0.4
Medication: Atenolol	0.1	0.1	0.5	0.1	0.5	0.1	-0.0	0.3	0.1	-0.1	-0.7	-0.7	0.1	0.2	-0.1	0.4
Sitting height	0.1	1.0	8.4	-1.0	1.3	0.2	-0.1	0.5	0.7	0.2	-0.6	2.9	0.5	0.5	0.0	0.1
Impedance of leg (left)	0.1	0.7	2.9	-1.7	0.2	0.3	1.4	0.2	1.1	0.6	-0.5	0.5	0.6	0.5	-1.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.3	0.6	0.1	0.0	-0.3	0.2	0.3	-0.1	1.1	-0.6	0.0	-0.1	-0.4	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	1.1	0.7	-0.3	-0.0	-0.0	1.1	0.1	0.2	-0.9	0.4	0.2	0.2	-0.2	0.5
Medication: Cholesterol lowering	0.1	0.2	0.6	0.7	-0.4	0.0	-0.3	0.4	0.8	0.1	0.7	0.1	0.2	-0.1	-0.5	0.3
Hair/balding pattern: Pattern 4	0.1	0.4	1.3	0.5	0.5	0.8	0.4	0.3	0.4	0.5	0.5	-0.5	0.7	0.6	1.1	0.4
Birth weight of first child	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.4	0.0	-0.5	0.0	-0.5	-0.2	-0.3	-0.0	-0.1	-0.3
Pulse wave reflection index	0.1	0.2	0.6	-0.3	0.7	0.4	0.1	-0.1	0.4	0.2	0.4	-0.2	0.4	0.5	0.6	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.7	0.1	-0.3	-0.3	-0.4	-0.8	-0.4	-0.3	0.3	0.1	-0.5	-0.4	-0.4	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.5	-0.1	0.0	0.3	0.4	0.6	0.6	0.3	0.4	0.4	0.1	0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	-0.1	0.1	-0.2	-0.5	0.0	-0.2	-0.4	0.1	-0.7	-0.4	-0.2	-0.5	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.7	0.3	0.1	-0.3	-0.5	-0.2	0.4	-0.6	0.1	0.1	0.2	0.2	-0.3
Leg fat percentage (right)	0.1	0.5	5.3	0.6	-0.2	-0.2	-0.8	0.2	0.0	0.0	0.1	2.3	-0.4	-0.1	-0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	1.7	-0.0	0.3	0.3	-0.0	-0.2	0.2	0.3	-0.1	-1.3	0.2	0.2	0.5	-0.2
Medication: Allopurinol	0.1	0.1	0.8	0.2	-0.3	-0.1	-0.0	-0.3	0.0	0.3	-0.1	-0.9	-0.1	-0.1	-0.5	0.5
Medication: Aspirin	0.1	0.1	0.3	-0.2	-0.1	0.0	-0.5	0.1	0.1	0.4	-0.4	0.6	0.0	0.1	-0.5	0.4
Friendships satisfaction	0.1	0.1	0.3	-0.0	-0.4	0.2	0.3	-0.5	0.3	0.2	0.3	0.5	0.2	0.0	0.0	-0.3
Mineral and other dietary supplements	0.1	0.1	0.5	0.4	-0.1	0.1	-0.1	0.6	0.4	0.2	0.2	-0.6	0.1	0.2	0.7	0.2
Medication: Aspirin	0.1	0.2	0.7	-0.1	-0.1	0.2	-0.3	0.4	0.4	0.5	-0.4	0.8	0.3	0.3	-0.4	0.7
Wears glasses or contact lenses	0.1	0.1	0.7	-0.4	0.4	0.1	0.4	0.3	-0.2	0.2	-0.4	0.8	0.1	0.2	0.2	0.4
Hearing aid user	0.1	0.1	0.5	-0.0	0.0	0.1	-0.2	-0.1	0.3	-0.2	-0.4	0.1	-0.0	-0.1	-0.6	-0.7
Medication: Paracetamol	0.1	0.2	0.7	-0.6	-0.2	-0.2	0.2	0.2	-0.5	-0.0	-0.5	-0.8	-0.3	0.1	-0.6	0.6
Illnesses of father: High blood pressure	0.1	0.2	1.6	-0.1	0.1	0.1	0.2	-0.2	-0.1	-0.3	0.3	-1.3	-0.1	-0.1	-0.6	-0.1
Myopia	0.1	0.2	0.7	0.1	-0.4	0.0	0.3	0.4	0.9	0.3	0.2	0.4	0.4	0.2	0.3	0.6
Intelligence (Savage-Jansen 2018)	0.0	0.2	1.1	0.4	0.3	0.5	0.0	0.0	0.4	0.1	0.2	-0.2	0.3	0.3	-0.0	-1.1
Blood Platelet Count	0.0	0.4	1.7	1.0	-0.6	-0.1	-1.0	0.6	-0.2	-0.7	1.3	-0.4	-0.3	-0.3	-0.1	-0.3
Hair Pigment	0.0	0.9	2.6	-0.4	0.8	0.9	0.3	1.1	1.0	1.6	1.2	-0.2	0.8	1.0	0.6	1.4
Hand grip strength (left)	0.0	0.1	0.6	-0.1	0.8	0.1	0.6	0.4	-0.1	0.2	0.1	-0.3	0.2	0.3	-0.2	0.4

Hub : Genes

ATXN10

Models

Trait associations