Best TWAS P=2.02e-32 · Best GWAS P=7.98e-81 conditioned to 1.01e-35
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | PUS10 | 0.01 | -0.01 | lasso | 1 | 0.08 | 5.9e-03 | 11.9 | 11.9 | 2.0e-32 | -0.57 | 0.02 | 0.24 | TRUE |
| 2 | GTEx | Colon Sigmoid | PUS10 | 0.24 | 0.17 | enet | 35 | 0.13 | 2.1e-05 | -1.3 | -8.6 | 1.1e-17 | 0.22 | 0.33 | 0.04 | TRUE |
| 3 | GTEx | Colon Transverse | PUS10 | 0.14 | 0.08 | lasso | 2 | 0.07 | 3.2e-04 | -5.5 | -5.7 | 1.1e-08 | 0.01 | 0.44 | 0.05 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | EHBP1 | 0.24 | 0.03 | enet | 16 | 0.11 | 1.1e-05 | -3.6 | -8.0 | 1.8e-15 | 0.07 | 0.02 | 0.86 | TRUE |
| 5 | GTEx | Thyroid | FAM161A | 0.11 | 0.03 | enet | 7 | 0.06 | 3.1e-05 | -3.7 | -6.7 | 2.3e-11 | 0.05 | 0.32 | 0.56 | FALSE |
| 6 | METSIM | Adipose | PUS10 | 0.06 | 0.04 | blup | 364 | 0.04 | 3.5e-06 | -1.8 | -6.8 | 1.4e-11 | 0.03 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FAM161A | 0.08 | 0.00 | blup | 41 | 0.02 | 4.0e-02 | 3.1 | -5.2 | 2.5e-07 | 0.05 | 0.01 | 0.52 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | B3GNT2 | 0.04 | 0.02 | blup | 39 | 0.02 | 2.4e-03 | -3.5 | -6.9 | 4.4e-12 | 0.05 | 0.03 | 0.06 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM161A | 0.08 | 0.02 | enet | 11 | 0.03 | 2.9e-04 | -5.6 | -6.1 | 1.2e-09 | 0.05 | 0.00 | 0.73 | FALSE |