Hub : Genes

EHBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0830	0.0310	3.2e-04	0.016	NA	0.019	NA	0.016	2.2e-02	NA	1.4e-02	NA	2.1e-02
2	GTEx	Esophagus Mucosa	0.1220	0.0570	1.4e-03	0.031	NA	0.051	NA	0.033	3.4e-03	NA	2.6e-04	NA	2.9e-03
3	GTEx	Heart Atrial Appendage	0.2390	0.0920	2.2e-03	0.034	NA	0.111	NA	0.098	1.2e-02	NA	1.1e-05	NA	3.5e-05
4	GTEx	Nerve Tibial	0.0898	0.0429	7.7e-04	0.021	NA	0.008	NA	0.007	1.1e-02	NA	8.4e-02	NA	9.9e-02
5	METSIM	Adipose	0.0527	0.0219	4.6e-04	-0.002	0.014	0.005	0.014	0.003	9.4e-01	3.0e-03	5.2e-02	0.0032	9.7e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.1208	0.0577	4.9e-06	0.061	0.053	0.045	NA	0.055	2.2e-07	1.1e-06	8.3e-06	NA	8.3e-07
7	TCGA	Lung Adenocarcinoma	0.0410	0.0246	8.8e-03	0.003	0.014	-0.001	NA	-0.001	1.3e-01	7.9e-03	5.4e-01	NA	3.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.0	1.6	5.5	0.7	1.3	-0.6	0.8	-2.3	0.9	1.3
Bipolar Disorder or Schizophrenia	0.9	2.3	5.7	0.9	-1.2	-1.1	2.4	-2.2	-0.6	1.2
Depressed Affect (Nagel 2018)	1.1	2.3	5.5	-1.0	-2.0	-1.1	1.9	0.6	-2.3	-0.4
Depression (Nagel 2018)	2.3	3.4	8.9	-1.1	-2.9	-0.8	2.2	0.2	-3.0	-0.7
Intelligence (Savage-Jansen 2018)	1.3	4.1	14.8	-0.0	1.4	2.3	-3.9	1.7	1.4	-1.3
Neuroticism (Nagel 2018)	1.3	2.9	7.9	-0.8	-2.0	-0.7	2.8	0.2	-2.7	-0.3
Schizophrenia (2018)	1.2	2.5	6.3	0.5	-2.5	-1.0	2.4	-0.9	-1.6	0.6
Schizophrenia vs Biploar Disorder	1.1	1.5	4.4	-1.0	-2.1	-1.3	0.9	0.5	-1.3	-0.6
Worry (Nagel 2018)	1.2	2.5	5.1	-1.7	-2.0	0.1	2.3	0.3	-2.1	-0.7
Alzheimer’s Disease (in mother)	1.2	1.4	4.1	-0.9	-0.2	0.3	-2.0	1.8	-0.6	-1.1
Alzheimer’s Disease (in father)	3.0	3.3	7.6	-2.0	-1.5	-2.8	1.0	0.3	-1.9	-2.1
Alzheimer’s Disease (including proxy)	2.2	3.2	6.6	-2.2	-1.3	-1.3	-1.1	1.8	-1.7	-2.6
Crohns Disease (2017)	0.4	0.8	3.2	-0.3	0.0	-1.8	0.8	-1.2	0.2	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.5	0.2	0.2	0.4	-0.7	0.2	0.6
Ulcerative Colitis (UC)	0.3	0.6	3.3	-0.2	0.5	1.8	0.3	-0.5	0.2	0.7
Major Depression (MDD)	0.2	0.2	1.0	-0.6	-0.4	-0.1	1.0	-0.0	-0.0	-0.0
Reaction Time	0.3	0.5	1.5	-0.0	0.6	0.8	0.0	-1.2	0.9	0.7
Verbal and Numeric Reasoning (VNR)	1.8	4.2	15.8	1.0	1.9	1.4	-4.0	1.9	1.9	-0.0
Breast Cancer	0.8	2.0	3.9	-1.4	-1.2	1.8	0.1	1.1	-1.4	-2.0
Ovarian Cancer	0.4	0.5	2.3	-0.0	0.2	0.7	-0.2	-0.8	1.5	0.3
Prostate Cancer	20.2	28.4	73.3	8.6	8.4	4.0	-6.2	-0.7	0.0	0.0
Age at First Birth	1.0	1.4	3.7	1.9	0.5	-0.5	0.4	-1.7	0.5	1.5
Bipolar Disorder (2011)	0.9	0.9	4.1	-0.1	0.6	0.0	1.1	-2.0	0.4	0.1
Body Mass Index (BMI) (2010)	2.6	3.6	6.7	1.2	2.4	1.2	-2.6	2.1	1.8	1.4
Coronary Artery Disease (CAD)	0.8	1.0	3.0	0.2	0.5	-1.0	-1.7	0.2	1.6	-0.0
Crohns Disease (2012)	0.2	0.4	1.9	-0.2	-0.5	-1.4	-0.5	-0.2	0.5	0.3
Mean Putamen Volume	1.1	1.2	2.3	1.5	0.7	1.4	-1.0	-0.3	1.3	1.1
Fasting Glucose	0.7	0.8	2.8	-1.1	-0.7	0.2	0.2	-0.1	-0.9	-1.7
HbA1C	1.7	1.9	4.7	0.1	1.6	2.2	-0.6	-0.2	1.8	1.6
HDL Cholesterol	0.4	0.6	3.2	0.2	-0.7	-0.3	0.8	-1.8	-0.1	0.4
LDL Cholesterol	5.1	8.1	25.3	1.3	1.4	3.0	-4.0	5.0	0.7	1.6
Lupus	0.7	1.1	3.3	-0.1	0.8	1.8	-1.2	1.6	-0.0	-0.2
Neuroticism (2016)	1.8	2.6	11.2	-0.8	-1.1	-1.3	3.3	-0.6	-1.8	-0.0
Primary Biliary Cirrhosis	0.7	0.9	4.0	0.9	0.5	-2.0	-0.8	0.7	-0.4	0.2
Rheumatoid Arthritis	0.9	1.3	4.8	0.9	-0.0	1.3	-0.5	2.2	-1.1	0.4
Schizophrenia (2014)	1.0	2.1	6.1	0.6	-1.9	-0.6	2.5	-1.4	-1.0	1.2
Triglycerides	0.3	0.6	1.9	-0.2	-0.2	0.7	-0.4	1.4	-1.0	-0.5
Type 2 Diabetes (T2D) (2012)	2.1	2.5	3.9	1.8	1.6	0.9	-1.2	-1.6	2.0	1.7
Ulcerative Colitis	1.0	1.4	8.0	-0.2	0.8	2.8	-0.0	0.0	0.4	1.0
Blood Eosinophil Count	0.1	1.0	3.2	0.8	-1.0	0.7	-1.1	1.8	0.1	0.8
Blood Platelet Count	0.2	2.7	8.0	0.6	1.9	0.0	-2.8	2.0	1.4	0.7
Blood Red Count	1.2	11.8	63.3	-1.0	-3.1	-8.0	1.0	0.7	-2.1	-1.8
Blood White Count	0.3	2.3	4.0	-1.8	-1.6	-0.4	-0.9	2.0	-1.2	-2.0
Heel T-Score	0.3	2.0	4.8	-1.9	-0.4	1.2	-0.8	2.2	-0.5	-1.7
BMI	2.4	14.2	20.2	4.2	3.8	2.2	-4.2	2.3	4.5	4.4
Height	0.1	1.0	2.8	1.7	0.4	-0.8	0.2	-0.3	1.3	1.3
Waist Hip Ratio (WHR)	0.1	0.7	1.6	1.1	-1.2	0.8	0.3	0.5	-0.9	0.2
Systolic Blood Pressure	0.5	2.6	4.3	-1.2	-1.7	0.9	1.0	-2.0	-1.9	-2.1
Smoking Status	3.8	9.1	15.5	-3.3	-3.9	-1.4	3.9	-1.9	-2.8	-2.9
Allergy or Eczema	0.9	2.4	6.8	2.1	0.2	1.0	-1.2	0.9	1.5	2.6
Cardiovascular Disease	0.4	1.2	3.2	1.3	0.5	1.0	-1.5	1.8	0.1	0.3
Hypothyroidism (self reported)	1.2	2.7	8.8	-1.7	-1.3	3.0	2.0	0.4	-0.6	-1.1
Respiratory disease	0.9	2.0	4.2	2.0	-0.6	0.4	-1.2	2.0	1.0	1.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.0	0.2	0.8	1.4	-1.7	-0.4	1.0	-0.3
Lung FEV1/FVC ratio	0.6	2.8	6.2	-1.4	-0.2	-1.1	2.5	-1.9	-1.6	-2.0
Lung FVC	2.3	11.7	25.0	-5.0	-3.2	-1.7	4.1	-1.2	-3.2	-3.8
Neuroticism	1.5	3.7	13.5	-1.3	-1.9	-1.2	3.7	-0.5	-2.3	-0.5
Chronotype (morning person)	1.0	2.3	6.3	1.0	0.5	-0.5	2.5	-1.9	0.3	2.1
Hair Pigment	0.1	1.8	6.3	1.7	-0.4	0.5	0.4	2.5	-0.1	1.7
Tanning	1.4	16.8	33.1	-5.8	-4.4	-1.7	3.1	2.1	-4.9	-4.9
Hand grip strength (left)	0.2	0.6	3.3	-0.2	1.8	-0.0	0.3	-0.4	0.7	0.4
Number of treatments/medications taken	0.5	0.9	2.4	-0.8	-1.5	0.7	1.5	-0.0	-0.7	0.6
Average weekly spirits intake	0.9	1.1	3.2	-1.3	-0.8	-1.0	0.2	0.3	-1.1	-1.8
Sensitivity / hurt feelings	0.1	0.1	0.5	0.4	0.1	0.1	-0.3	0.7	-0.2	0.1
Frequency of depressed mood in last 2 weeks	2.2	3.1	7.2	-1.3	-2.7	-0.5	2.3	0.0	-2.7	-0.2
Hearing difficulty/problems: Yes	1.5	2.4	5.2	1.4	2.2	0.2	-1.4	-1.4	2.3	0.8
Relative age of first facial hair	1.7	3.6	10.0	1.0	-0.3	-2.1	2.6	-3.2	0.6	1.5
Other serious medical condition/disability diagnosed by doctor	4.9	6.4	12.3	3.0	1.5	3.5	-2.2	0.0	2.4	3.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.2	-1.6	-0.7	-0.9	0.1	-0.2	-0.7	-1.8
Ever had hysterectomy (womb removed)	1.1	1.3	4.3	0.9	0.8	0.4	-0.1	-1.6	2.1	0.9
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.3	-0.3	0.8	-0.5	0.1	-0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.5	0.3	0.8	-0.6	-0.2	0.5	0.9
Angina	1.2	1.6	3.5	1.9	1.0	0.0	-1.4	0.2	1.5	1.6
Medication for hormone replacement therapy	2.7	3.1	8.8	-1.7	-0.7	-0.8	3.0	-2.4	-1.3	-1.2
Vitamin and mineral supplements	1.8	2.4	6.7	1.2	1.4	-0.0	-2.6	2.4	0.8	0.6
Supplements: Zinc	2.7	2.9	7.3	-1.8	-1.5	-1.2	2.7	-0.9	-1.9	-1.3
Medication: Co-codamol	0.3	0.3	0.9	0.1	-1.0	0.2	0.8	-0.4	-0.5	-0.5
Medication: Metformin	1.2	1.6	4.1	1.0	1.1	1.4	-2.0	-0.7	1.5	0.4
Diabetes (father)	0.2	0.2	0.5	0.1	-0.7	0.6	-0.7	0.4	0.1	-0.2
Diabetes (mother)	1.7	2.1	6.5	1.2	2.5	1.2	-0.4	-0.8	1.4	1.6
Severe depression (siblings)	2.1	2.3	8.3	1.6	0.2	1.1	0.9	-1.1	1.4	2.9
Pack years adult smoking proportion	1.5	2.4	6.2	-1.7	-2.5	-1.0	0.5	-0.1	-1.4	-2.0
Impedance of leg (right)	1.7	8.0	17.9	-1.6	-2.9	-2.2	4.2	-2.4	-3.2	-2.5
Leg fat-free mass (left)	2.2	11.5	17.5	3.4	3.3	2.4	-3.8	2.1	4.1	4.2
Trunk fat percentage	1.6	6.6	13.8	3.7	2.3	0.7	-3.0	1.7	2.7	2.8
Hand grip strength (right)	0.8	2.2	9.2	0.5	3.0	0.3	-1.7	0.5	1.4	0.7
Townsend deprivation index at recruitment	0.7	1.0	2.2	-1.4	-0.1	0.3	0.8	0.1	-1.3	-1.5
Current tobacco smoking	3.0	4.9	11.7	-2.4	-3.4	-0.8	1.5	-0.2	-2.2	-3.1
Average weekly fortified wine intake	0.9	1.0	3.8	-0.1	0.8	0.5	1.4	-1.9	0.6	0.4
Maternal smoking around birth	3.0	4.3	11.6	-2.1	-3.4	-1.6	2.0	-1.2	-1.8	-1.8
Fed-up feelings	0.7	1.2	3.7	-0.7	-1.2	-0.9	1.1	0.9	-1.9	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	8.5	-1.0	-2.2	0.0	2.9	-0.9	-2.0	-0.2
Relative age voice broke	0.3	0.4	1.0	0.7	-0.7	-1.0	0.2	-0.8	0.2	-0.1
Taking other prescription medications	0.4	0.7	2.1	-0.7	-1.1	1.4	0.7	-0.1	-0.5	0.1
Age when periods started (menarche)	0.5	1.3	4.6	0.3	-0.1	-1.3	-2.1	1.5	0.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.4	0.1	-0.3	-0.2	-0.7	0.7	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.7	-0.6	1.1	-0.1	1.2	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	-0.0	-1.2	-0.9	-1.1	0.6	0.1	0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.1	-0.6	-0.2	0.7	-0.5	-0.2	0.4
Serious illness, injury or assault to yourself	1.4	1.7	6.4	1.3	1.1	-0.9	-0.7	0.6	0.9	2.5
High blood pressure	0.1	0.3	0.9	0.5	0.4	0.3	0.2	0.1	-1.0	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.2	1.2	-0.1	1.0	-1.4	1.1	1.3	1.8
Multivitamins +/- minerals	1.8	2.3	5.3	-1.3	-2.2	0.8	2.3	-1.6	-0.9	-0.6
Stomach or abdominal pain in last month	1.5	1.9	8.2	-0.6	-2.9	-0.9	1.4	0.3	-1.3	-0.6
Supplements: Glucosamine	2.1	2.7	6.6	-2.4	-1.1	0.4	1.4	0.7	-1.7	-2.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	6.2	-0.9	-2.5	0.5	0.4	0.8	-1.7	-1.2
Medication: Atenolol	1.2	1.6	4.9	2.2	0.4	1.4	-1.5	-0.2	0.9	1.0
Medication: Levothyroxine sodium	0.8	1.4	6.1	-0.4	-0.4	2.5	1.8	0.3	-0.3	-0.4
Sitting height	0.3	2.4	7.6	0.8	0.8	2.8	-1.5	-0.1	2.1	1.3
Chronic bronchitis/emphysema (father)	0.9	1.1	2.9	-0.4	-1.5	0.1	0.2	1.4	-1.7	-0.6
High blood pressure (mother)	2.1	2.9	9.5	1.5	1.6	1.2	1.0	-3.1	1.0	1.6
Body mass index (BMI)	2.8	11.8	18.3	4.2	3.0	1.5	-4.1	2.3	3.7	4.3
Impedance of leg (left)	1.6	7.8	16.4	-1.5	-2.6	-2.1	4.0	-3.0	-3.0	-2.5
Leg predicted mass (left)	2.2	11.4	17.3	3.4	3.4	2.3	-3.7	2.1	4.1	4.2
Trunk fat mass	2.6	11.2	19.9	4.5	3.2	1.4	-3.6	1.6	3.8	4.0
Waist circumference	3.3	11.9	22.1	4.7	2.9	1.8	-3.9	2.0	3.5	4.4
Number of incorrect matches in round	0.5	0.8	1.2	0.5	-0.3	-1.0	1.1	-1.0	-1.0	0.9
Past tobacco smoking	1.7	3.2	5.6	2.1	1.8	-0.4	-2.4	0.9	2.1	1.8
Alcohol usually taken with meals	0.3	0.5	0.8	0.8	0.6	0.9	-0.6	0.0	0.7	0.8
Nervous feelings	1.6	3.0	9.2	-1.4	-1.8	0.1	3.0	-0.3	-2.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	10.3	-1.9	-2.6	-0.4	3.2	-0.6	-2.4	-0.5
Hearing difficulty/problems with background noise	0.7	1.2	2.9	0.9	1.5	0.6	-0.7	-0.6	1.7	0.9
Hair/balding pattern: Pattern 2	2.5	3.1	8.4	2.9	1.6	1.2	-2.1	0.2	1.1	1.9
Had menopause	0.1	0.2	0.4	-0.2	0.6	-0.6	0.3	-0.5	-0.1	-0.1
Had other major operations	1.6	2.0	4.4	-1.8	-2.0	-0.1	-0.1	1.0	-1.1	-2.1
Forced vital capacity (FVC)	0.6	2.4	6.7	-1.8	-1.2	-1.0	2.6	-1.5	-0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	-1.0	-0.4	1.6	-0.6	1.3	0.4	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	1.0	-0.9	-0.6	0.3	0.4	-0.1	1.4
Qualifications: None of the above	1.7	3.7	6.4	-2.3	-2.5	-1.8	1.4	0.7	-2.0	-2.2
Financial difficulties in last 2 years	0.9	1.2	3.7	-0.2	-1.2	0.4	1.9	-1.3	-0.1	1.0
Mouth/teeth dental problems	1.7	2.6	5.5	1.2	2.4	1.3	-1.4	0.4	2.2	1.6
Heart attack	6.0	7.7	16.6	3.1	3.1	1.4	-4.1	0.7	3.0	2.6
Allergy	1.2	2.8	6.7	-2.1	-0.1	-1.5	1.5	-0.9	-1.8	-2.6
Pain all over the body in last month	1.6	1.7	2.6	-1.4	-1.6	-1.6	1.3	0.7	-1.3	-0.9
Diabetes (self-reported)	0.2	0.3	0.7	-0.7	0.0	0.6	-0.9	-0.3	0.3	-0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	0.4	1.1	0.4	-0.8	0.3	1.2	0.9
Medication: Ramipril	0.3	0.4	0.6	0.8	0.7	-0.6	-0.5	-0.4	0.5	0.7
Medication: Simvastatin	1.1	1.6	4.4	1.0	0.5	0.6	-2.0	2.1	0.6	0.9
Fluid intelligence score	1.0	2.0	7.2	-0.0	1.0	1.1	-2.7	1.6	0.8	-1.1
Illnesses of siblings	2.2	3.2	8.4	-1.0	-1.6	-1.9	2.9	-1.7	-1.7	-0.7
Neuroticism score	1.5	3.0	9.5	-1.2	-1.8	-1.0	3.1	-0.2	-2.4	-0.4
Weight	3.1	15.1	25.1	4.8	3.7	2.2	-4.1	1.6	4.5	5.0
Impedance of arm (right)	1.4	6.5	16.2	-2.9	-2.3	-1.2	2.2	-0.0	-3.0	-4.0
Arm fat percentage (right)	2.0	8.1	13.0	3.5	2.5	1.2	-3.6	2.2	3.0	3.1
Trunk fat-free mass	1.9	10.8	21.3	3.5	3.1	2.1	-3.2	1.2	4.0	4.6
Hip circumference	3.4	14.8	26.1	4.7	3.8	1.1	-3.9	1.5	4.7	5.1
Time employed in main current job	0.5	0.6	2.0	0.2	-0.6	-1.4	0.2	1.2	-0.5	-0.1
Alcohol intake versus 10 years previously	0.7	1.1	4.4	-0.4	0.2	-0.5	-1.6	2.1	0.4	0.1
Father’s age at death	1.4	1.9	3.6	-1.5	-1.2	-0.1	1.9	-0.4	-1.7	-1.7
Worrier / anxious feelings	0.2	0.5	2.5	0.0	-0.1	-0.1	1.6	-0.0	-0.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	3.0	0.4	-0.7	0.6	1.6	-1.5	0.2	1.7
Falls in the last year	0.3	0.4	0.9	-0.2	-0.6	-0.5	-0.1	0.9	-0.5	1.0
Hair/balding pattern: Pattern 3	1.5	2.2	4.4	-1.9	-2.1	-1.1	1.7	0.7	-1.4	-1.1
Number of live births	0.5	0.6	1.8	-0.9	-1.4	-0.9	-0.4	0.9	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.9	9.6	-2.3	-1.5	-1.6	3.1	-1.6	-1.1	-1.7
Pulse rate	0.5	0.8	1.5	-0.7	-0.7	0.2	1.2	-1.2	-1.1	-0.7
Happiness	1.3	1.6	4.6	-0.6	-2.1	0.8	1.7	-0.1	-1.5	0.5
Noisy workplace	1.8	2.3	6.2	1.4	1.0	-2.5	-0.3	-1.5	1.4	1.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.0	1.4	0.7	0.8	-1.0	-0.7	0.7	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.7	0.8	1.2	-0.1	-1.1	-0.6	1.7	1.4
Mouth/teeth dental problems: Dentures	0.7	1.3	3.3	-1.3	-1.2	-0.9	-0.2	0.4	-1.2	-1.8
Asthma	0.4	0.8	2.0	0.8	-0.4	0.8	-0.4	1.2	0.6	1.4
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	7.5	-1.2	-2.6	-1.3	2.7	0.1	-1.4	-0.6
Medication: Cholesterol lowering	1.6	2.5	5.2	1.6	0.7	0.5	-2.3	1.8	1.2	2.1
Depression (self-reported)	2.5	3.0	9.9	-1.7	-0.8	0.5	3.1	-1.4	-2.1	-0.9
Medication: Lansoprazole	0.3	0.4	1.1	0.4	-1.0	-0.6	0.3	-1.0	-0.1	0.4
Prospective memory result	1.2	1.4	2.2	1.0	1.5	1.0	-1.3	0.4	1.4	1.4
Lung cancer (father)	2.7	3.1	6.4	-1.8	-0.5	-2.5	1.6	-1.6	-1.3	-2.3
Illnesses of mother	4.1	5.1	10.1	-2.0	-3.2	-2.0	1.7	1.6	-2.7	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	8.1	-2.8	-1.4	-0.6	2.6	-0.6	-0.9	-1.6
Pulse wave Arterial Stiffness index	2.6	3.0	6.6	-2.6	-0.7	-1.2	1.7	-0.7	-2.0	-2.3
Impedance of arm (left)	1.1	5.1	14.2	-2.5	-2.0	-0.9	1.8	-0.2	-2.7	-3.8
Arm fat mass (right)	2.8	11.5	17.9	4.2	3.2	1.9	-3.9	2.1	3.7	4.0
Trunk predicted mass	1.8	10.5	21.1	3.4	3.1	2.1	-3.1	1.1	4.0	4.6
Standing height	0.3	2.7	4.8	1.8	1.9	1.5	-0.3	-0.8	2.2	2.1
Length of working week for main job	1.4	1.6	2.4	1.4	1.5	1.1	-0.9	0.0	1.5	1.4
Exposure to tobacco smoke at home	0.4	0.4	0.9	-1.0	-0.3	0.7	0.9	0.6	-0.1	-0.6
Breastfed as a baby	1.7	2.1	4.5	1.6	2.0	0.7	-2.1	0.5	1.2	1.1
Tense / ‘highly strung’	4.3	7.1	14.5	-2.8	-3.3	-0.2	3.8	-0.2	-3.6	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.9	-0.2	-1.4	1.2	2.0	-0.7	-1.7	0.7
Hair/balding pattern: Pattern 4	0.3	0.8	4.2	0.1	0.2	-0.5	-0.8	2.1	0.4	0.0
Birth weight of first child	0.3	0.5	1.2	-0.1	0.1	-0.2	-1.1	1.1	0.9	0.4
Peak expiratory flow (PEF)	0.3	0.6	2.2	-0.2	1.0	0.1	0.1	-1.5	1.1	-0.0
Pulse wave reflection index	2.2	2.7	6.8	-1.8	-0.7	-1.0	2.6	-1.7	-1.3	-1.7
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.6	-0.8	-0.4	0.9	0.9	-1.9	-0.1	-0.3
Loud music exposure frequency	1.7	1.8	4.3	1.6	1.1	-0.0	-1.1	-0.3	1.9	2.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.2	0.5	0.7	0.4	-1.5	-0.2	1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	1.3	0.4	0.2	-0.7	-0.3	0.5	1.2
Blood clot in the leg (DVT)	1.4	1.8	4.7	2.2	0.0	-1.1	-0.1	-1.0	1.3	2.0
Medication: Paracetamol	1.8	2.9	5.9	-2.4	-1.9	-2.0	1.7	0.2	-1.4	-1.3
Headache pain in last month	1.3	2.2	4.6	-1.7	-2.1	-1.0	1.7	-0.1	-1.5	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.0	-1.4	-0.1	0.7	1.2	-0.9	-0.2	-1.1
Glaucoma (self-reported)	0.3	0.3	1.0	-0.8	-0.4	0.3	-0.5	-0.2	1.0	0.3
Gout (self-reported)	0.3	0.4	0.8	-0.9	-0.6	0.3	0.6	-0.7	-0.6	-0.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	6.1	-1.2	-0.5	2.5	1.1	0.8	-0.2	-0.8
Medication: Amlodipine	0.7	1.0	2.2	-1.1	-1.4	0.6	0.5	-0.5	-0.8	-1.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	5.2	0.3	-0.7	-1.3	-1.2	2.3	0.1	0.0
Birth weight	0.6	1.4	3.1	0.6	0.9	-0.2	-0.5	1.6	1.6	1.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	-0.5	0.4	1.2	-0.2	1.0	0.0	0.7
High blood pressure (siblings)	0.1	0.2	0.5	-0.1	0.1	-0.7	-0.6	0.6	-0.2	-0.3
Forced vital capacity (FVC), Best measure	0.6	2.1	6.1	-2.2	-1.4	-0.3	2.5	-0.4	-0.7	-0.9
Body fat percentage	1.8	6.9	14.7	3.8	2.2	0.6	-3.0	1.6	2.8	3.1
Leg fat percentage (right)	1.6	5.9	13.5	3.7	1.9	0.5	-2.3	1.3	2.3	3.4
Arm fat-free mass (right)	2.4	12.3	26.6	4.1	3.3	2.1	-3.0	0.4	4.3	5.2
Exposure to tobacco smoke outside home	1.2	1.7	6.1	-1.0	0.1	-0.5	2.5	-2.0	-0.3	0.4
Comparative body size at age 10	0.8	2.3	4.3	2.1	2.1	1.4	-1.6	1.2	0.2	1.3
Number of full brothers	0.7	0.9	3.1	-0.4	-0.6	0.4	-1.8	1.4	-0.3	-0.8
Worry too long after embarrassment	0.8	1.3	4.0	0.8	0.9	-0.0	2.0	-1.5	-0.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.9	-1.1	-1.3	0.2	2.2	-1.1	-1.4	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	0.4	-0.9	0.4	0.4	1.2	0.3	0.8
Number of children fathered	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.1	-0.6	0.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	-0.1	-0.5	-0.4	1.4	-1.2	-0.1	0.5
Age at first live birth	0.8	1.3	4.3	2.1	0.7	-0.2	-0.8	0.2	0.9	1.7
Pulse wave peak to peak time	3.1	3.6	7.5	2.7	0.9	1.4	-1.7	0.7	2.2	2.6
Health satisfaction	0.8	1.0	3.2	0.2	-0.8	1.8	0.3	1.0	-0.4	1.3
Shortness of breath walking on level ground	1.2	1.4	5.7	0.6	0.7	2.4	-0.2	0.8	0.4	1.5
Qualifications: College or University degree	1.1	3.4	8.5	2.9	1.8	0.7	-0.9	0.2	1.7	2.8
Eye problems/disorders: None of the above	0.6	0.7	1.5	0.3	-0.2	-1.1	1.2	-0.8	-0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-1.2	-1.2	-0.5	0.8	0.2	-0.5	-0.6
Emphysema/chronic bronchitis	2.8	3.2	8.0	-1.5	-2.0	-0.2	-0.5	2.8	-2.0	-1.9
Medication for pain relief, constipation, heartburn	0.6	1.1	3.5	1.1	1.9	0.6	-1.3	-0.1	1.0	-0.0
Neck or shoulder pain in last month	1.9	2.7	7.4	-2.7	-0.9	1.1	-0.4	2.0	-1.7	-1.6
Medication: Blood pressure	0.2	0.4	1.1	0.4	0.0	-0.7	-0.4	1.1	-0.7	-0.5
Angina (self-reported)	1.4	1.9	4.1	2.0	1.0	0.4	-1.5	0.1	1.6	1.8
Migraine (self-reported)	1.9	2.3	4.2	1.5	1.1	2.0	-0.8	-2.0	1.4	1.4
Medication: Ibuprofen	2.2	2.7	6.7	-1.4	-2.6	-1.3	2.4	-0.2	-1.4	-0.8
Medication: Allopurinol	0.3	0.4	2.2	0.3	0.2	0.1	0.4	-1.5	0.0	0.4
Medication: Omeprazole	0.3	0.3	0.9	-0.5	-0.3	0.7	0.6	0.4	-1.0	0.2
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-1.2	0.7	-0.2	0.1	0.4	-0.8	-1.2
Mean time to correctly identify matches	0.2	0.4	0.9	-0.1	0.7	0.2	-0.1	-1.0	0.9	0.3
Heart disease (mother)	2.1	2.6	5.9	0.7	2.4	1.0	-2.3	1.0	2.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.9	0.8	-0.1	-0.5	-0.1	0.3	0.4
Whole body fat mass	2.8	11.6	20.2	4.5	3.1	1.4	-3.8	1.8	3.8	4.2
Leg fat mass (right)	2.4	9.2	18.0	4.1	2.6	0.9	-3.0	1.5	3.2	4.2
Arm predicted mass (right)	2.4	12.4	25.6	4.1	3.4	2.1	-3.1	0.5	4.3	5.1
Pulse rate, automated reading	1.1	3.4	6.3	-1.8	-2.0	-0.5	2.4	-0.9	-2.5	-1.8
Alcohol intake frequency.	2.6	6.1	11.6	2.0	3.4	0.2	-3.1	0.8	3.1	2.7
Comparative height size at age 10	0.4	2.2	5.0	1.5	1.8	1.4	1.1	-2.2	0.5	1.2
Number of full sisters	0.2	0.2	0.7	-0.6	-0.2	0.2	-0.1	-0.1	0.9	0.5
Suffer from ‘nerves’	1.1	1.7	3.7	-1.5	-1.6	-0.0	1.9	-0.0	-1.8	-0.4
Overall health rating	0.3	0.7	2.0	0.3	-1.4	0.7	0.0	0.9	-0.2	1.3
Chest pain or discomfort	0.4	0.5	1.7	-0.0	-0.5	-1.3	1.0	0.2	0.5	0.7
Had major operations	0.9	1.1	2.8	1.7	0.7	0.7	-0.5	1.1	0.1	1.5
Age at last live birth	0.6	0.9	1.8	1.3	1.1	-0.6	-0.2	-0.4	1.1	1.4
Family relationship satisfaction	0.5	0.6	1.5	0.5	1.2	-0.3	-1.1	-0.3	1.1	0.6
Leg pain on walking	3.3	4.1	7.0	1.7	1.8	2.6	-1.6	1.4	2.1	2.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.7	-0.3	-1.1	-1.6	0.4	1.2	0.2	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.9	0.6	1.4	-0.9	0.6	-0.6	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.5	0.1	0.6	-0.4	-0.9	1.4	-0.7	-1.6
Medication: Aspirin	0.6	0.7	3.2	0.5	-0.1	0.4	-1.8	0.8	0.6	0.8
Supplements: Vitamin C	1.7	2.0	7.6	-1.0	0.7	-0.1	2.2	-2.8	0.4	-0.3
Knee pain experienced in last month	1.0	1.6	3.6	-1.0	-1.9	-1.3	1.3	1.3	-1.3	0.2
Hypertension (Self-reported)	0.1	0.2	0.7	0.6	0.3	0.2	0.5	0.1	-0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	10.1	-2.0	-3.2	-0.9	1.3	0.4	-2.1	-1.5
Illnesses of father: Heart disease	8.7	12.1	20.7	3.6	4.5	2.2	-4.4	-0.8	4.0	3.2
Illnesses of siblings: Diabetes	1.5	1.8	3.5	1.4	1.9	1.1	-0.9	-0.0	1.7	1.4
Smoking status: Previous	0.5	0.7	1.9	-1.0	0.1	0.6	1.4	-0.7	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.6	0.6	1.6	1.0	0.6	-1.4	1.4	1.4
Whole body fat-free mass	2.0	11.7	21.0	3.6	3.3	2.2	-3.5	1.4	4.2	4.6
Leg fat-free mass (right)	2.1	11.4	17.0	3.3	3.5	2.6	-3.8	1.8	4.1	4.0
Arm fat percentage (left)	2.1	8.5	13.8	3.6	2.6	1.4	-3.7	2.1	3.1	3.1
Average weekly red wine intake	0.0	0.1	0.2	-0.0	-0.5	0.4	-0.1	-0.1	0.1	-0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.7	-0.7	-1.4	-0.6	2.2	-1.2	-1.4	-0.6
Mood swings	1.2	2.2	8.8	-0.9	-1.3	-0.4	3.0	-0.9	-1.9	-0.2
Loneliness, isolation	0.8	1.1	3.3	-0.8	-1.4	0.4	0.7	0.4	-1.8	-0.9
Long-standing illness, disability or infirmity	1.6	2.5	6.2	1.9	0.3	0.6	-1.7	0.5	2.0	2.5
Ever had bowel cancer screening	0.6	0.6	2.4	-0.9	-1.6	-0.1	-0.1	0.2	-0.8	-0.7
Diabetes diagnosed by doctor	0.6	1.0	3.9	-0.1	0.9	1.0	-2.0	0.0	1.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	6.6	-1.5	-2.6	-1.2	0.3	1.2	-1.4	-1.3
Friendships satisfaction	0.2	0.2	1.0	-0.1	-1.0	0.3	-0.6	0.2	0.1	0.3
Qualifications: nursing, teaching	1.0	1.6	6.4	1.2	2.5	0.2	-0.7	0.6	1.2	1.1
Commuting to job workplace: Walk	0.3	0.3	1.2	0.4	-0.0	-0.8	-0.0	-1.1	-0.2	0.2
Eye problems/disorders: Cataract	0.7	0.8	3.0	0.7	0.0	0.4	-1.7	0.7	0.5	1.1
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	8.3	-1.2	-1.6	-1.6	2.9	-1.3	-2.4	-0.4
Medication for cholesterol	0.2	0.4	2.2	0.2	-0.2	-1.5	0.3	-0.2	0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.1	-1.0	-0.2	0.5	2.0	0.0	-1.4	-0.5
Back pain experienced in last month	1.1	1.6	4.7	0.1	0.4	-1.0	2.2	-1.7	0.2	1.5
Mineral and other dietary supplements	1.6	2.1	3.9	1.7	1.8	-0.4	-1.6	0.1	2.0	1.5
Breast cancer (self-reported)	0.4	0.5	1.2	-0.2	-0.8	-0.0	1.1	-1.0	0.6	0.6
Asthma (self-reported)	0.5	0.9	2.4	1.1	-0.5	0.8	-0.5	1.1	0.7	1.6
Osteoporosis (self-reported)	0.8	1.0	2.9	0.3	0.2	-0.1	1.5	-1.7	0.6	1.1
Osteoarthritis (self-reported)	0.5	0.6	2.0	-0.7	-0.6	-1.4	0.5	0.2	-0.9	-0.5
Medication: Aspirin	0.6	0.7	3.5	0.3	-0.1	0.3	-1.9	0.9	0.5	0.6
Medication: Gliclazide	0.4	0.5	2.0	-0.1	0.2	-0.2	-1.4	1.1	0.1	-0.4
Illnesses of father: None of the above (group 1)	1.0	1.3	3.9	-1.4	-1.2	-0.4	2.0	-0.9	-0.6	-0.6
Smoking status: Current	3.8	6.0	13.8	-2.6	-3.7	-1.1	2.1	-0.2	-2.4	-3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	11.2	-3.3	-1.1	-1.8	2.7	-0.7	-1.6	-2.6
Whole body water mass	2.1	11.9	21.1	3.7	3.3	2.3	-3.5	1.4	4.2	4.6
Leg predicted mass (right)	2.1	11.5	16.9	3.3	3.5	2.6	-3.8	1.8	4.1	4.0
Arm fat mass (left)	3.1	12.6	20.0	4.5	3.4	1.9	-4.1	2.1	3.9	4.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.5	1.2	0.1	1.6	-0.1	0.3	0.4	1.2
Average weekly champagne plus white wine intake	1.5	2.1	8.4	-0.0	-0.4	-0.8	2.9	-1.9	-1.3	0.2
Miserableness	0.4	0.6	1.6	-0.0	0.2	-0.3	1.1	-1.3	0.5	1.2
Guilty feelings	0.9	1.4	2.7	1.6	0.7	-1.2	0.9	-1.4	0.3	1.6
Wears glasses or contact lenses	1.4	1.6	3.0	0.7	0.9	-1.4	-1.7	1.7	1.0	0.9
Ever taken oral contraceptive pill	2.2	2.4	9.2	-0.5	-1.4	-0.3	1.4	-3.0	-1.0	-1.6
Hearing aid user	0.5	0.5	1.1	0.5	1.1	0.2	-0.1	-0.7	0.9	1.0
Mother’s age at death	0.9	1.1	3.7	0.2	1.9	1.1	-0.6	-1.0	1.1	0.7
Financial situation satisfaction	0.9	1.1	3.9	0.0	-2.0	0.1	1.3	-0.8	-0.7	0.9
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.8	-0.5	-0.5	-1.9	1.5	-0.2	-1.2	-0.3
Commuting to job workplace: Public transport	2.1	2.5	7.0	1.7	0.6	0.0	-1.4	-0.4	2.6	2.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	-0.8	-0.5	0.6	-0.7	0.4	0.7	0.3
Medication: Blood pressure	0.4	0.8	2.5	1.1	0.8	1.6	-1.0	-0.0	0.3	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.3	-0.6	0.1	-0.3	1.5	-1.0	-0.7	-0.2
Supplements: Fish oil (including cod liver oil)	2.1	2.8	4.7	-2.1	-2.2	-1.0	1.0	0.6	-2.1	-2.0
High cholesterol (Self-reported)	3.4	6.1	16.6	2.8	2.0	0.2	-4.1	2.5	1.9	2.0
Medication: Bendroflumethiazide	0.2	0.4	1.3	-0.0	-0.4	-0.2	0.2	0.7	-0.8	-1.1
Medication: Paracetamol	0.9	1.4	2.5	-1.6	-1.6	-1.3	0.9	0.4	-1.4	-0.8
Medication: Lisinopril	0.4	0.5	1.3	1.1	0.7	0.5	-0.6	0.5	0.4	0.5
Medication: Atorvastatin	1.8	2.3	4.4	2.1	1.1	1.1	-2.1	1.1	1.3	1.3
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.5	0.0	0.5	-0.6	-0.4	0.4	0.4
Alcohol drinker status: Never	3.1	3.8	5.7	1.9	2.4	1.7	-2.4	0.8	2.0	2.0
Ever smoked	2.9	5.0	10.8	-2.2	-2.7	-0.4	3.3	-1.8	-2.4	-1.7
Basal metabolic rate	2.4	13.2	22.8	4.0	3.5	2.4	-3.8	1.6	4.4	4.8
Leg fat percentage (left)	1.8	6.5	13.2	3.6	2.2	0.6	-2.6	1.1	2.6	3.4
Arm fat-free mass (left)	2.5	12.6	25.9	4.3	3.3	2.1	-3.2	0.7	4.2	5.1
Number of operations (self-reported)	0.2	0.3	0.7	-0.4	-0.9	0.3	0.3	0.1	-0.8	-0.5
Average weekly beer plus cider intake	1.8	2.6	5.3	-1.8	-2.0	-0.7	1.4	-1.5	-1.2	-2.3
Irritability	2.1	3.5	10.9	-1.2	-2.2	0.0	3.3	-0.4	-2.4	-1.3
Risk taking	1.6	2.4	11.0	0.1	-0.4	-1.3	1.9	-3.3	0.3	0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	5.1	0.2	0.0	0.8	-0.6	2.3	-0.8	0.1
Fractured/broken bones in last 5 years	1.3	1.7	3.5	1.1	1.2	0.8	1.1	-1.6	1.1	1.9
Age started oral contraceptive pill	1.9	2.4	5.1	2.2	2.2	0.1	-1.7	-0.5	1.2	1.6
Diastolic blood pressure, automated reading	0.3	0.9	1.3	-0.8	-0.9	0.9	1.1	-0.7	-1.2	-1.0
Ever depressed for a whole week	0.5	0.6	1.7	0.5	0.1	0.3	-1.3	0.8	0.1	1.1
Unable to work because of sickness or disability	0.6	0.8	2.3	-0.6	-1.5	0.1	1.0	-1.1	-0.8	-0.2
Commuting to job workplace: Cycle	0.5	0.6	1.6	-1.3	-0.7	0.4	-0.1	0.9	-0.2	-1.1
Myopia	1.4	2.1	4.3	1.9	2.1	-0.7	-0.9	-1.1	1.8	1.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	-0.8	-0.9	-0.5	0.7	-0.8	0.4	0.1
Cholesterol lowering medication	1.9	2.9	8.7	0.4	1.1	1.9	-3.0	2.4	0.9	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.6	-0.5	0.5	0.8	0.0	-0.7	0.3
Pain experienced in last month	1.7	2.8	6.5	2.3	1.6	1.4	-2.5	0.2	1.6	0.9
Supplements: Calcium	2.2	2.4	9.2	-0.4	-0.8	-0.3	2.5	-3.0	-0.6	0.3
Basal cell carcinoma (self-reported)	1.3	1.5	3.9	1.4	2.0	-0.2	-1.1	-0.8	1.0	1.3
Heart attack/myocardial infarction (self-reported)	5.3	6.8	15.1	2.8	2.9	1.2	-3.9	0.6	2.9	2.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.6	1.6	-0.3	-1.0	0.2	-0.8	0.8	1.4
Heart disease (siblings)	7.5	9.2	21.0	2.8	2.4	3.2	-4.6	1.0	3.8	2.1
Alcohol drinker status: Previous	1.8	2.1	4.9	1.3	1.2	-0.3	0.6	-2.2	1.2	2.2
Pack years of smoking	1.5	2.2	6.5	-1.5	-2.6	-1.0	-0.0	0.2	-1.3	-2.1
Impedance of whole body	1.5	7.4	12.8	-2.4	-2.5	-1.8	3.3	-1.7	-3.2	-3.6
Leg fat mass (left)	2.7	10.5	18.9	4.3	3.0	1.0	-3.4	1.4	3.6	4.3
Arm predicted mass (left)	2.7	13.8	27.1	4.5	3.6	2.2	-3.4	0.7	4.3	5.2