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chr2:241,477,073-243,048,760

Best TWAS P=4.65e-11 · Best GWAS P=4.03e-11 conditioned to 1.49e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SEPT2	0.18	0.11	enet	13	0.11	4.6e-05	-4.7	-6.6	4.7e-11	0.05	0.00	0.89	TRUE
7	GTEx	Cells Transformed fibroblasts	BOK	0.12	0.10	lasso	5	0.12	5.5e-09	5.5	6.1	1.1e-09	-0.03	0.00	1.00	TRUE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	SEPT2	0.24	0.04	blup	45	0.08	1.6e-09	-1.7	-6.4	2.1e-10	0.03	0.04	0.84	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPT2	0.21	0.02	enet	11	0.07	4.9e-15	-1.7	-6.2	5.7e-10	0.02	0.02	0.94	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEPT2	0.40	0.06	enet	14	0.17	8.0e-18	-1.7	-6.1	9.5e-10	0.02	0.04	0.86	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SEPT2	0.14	0.00	enet	7	0.02	7.7e-04	-4.8	-5.9	3.3e-09	0.02	0.01	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SEPT2	0.52	0.29	bslmm	377	0.44	2.0e-59	-4.2	-5.9	4.8e-09	0.02	0.33	0.59	FALSE
3	GTEx	Artery Aorta	AC005104.3	0.10	0.01	lasso	4	0.01	1.6e-01	4.4	-5.7	1.0e-08	0.03	0.08	0.16	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEPT2	0.51	0.10	enet	14	0.20	2.4e-22	-1.7	-5.7	1.4e-08	0.01	0.27	0.02	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SEPT2	0.42	0.11	enet	14	0.18	5.2e-08	-1.8	-5.7	1.6e-08	0.01	0.06	0.39	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEPT2	0.34	0.04	enet	14	0.12	1.3e-07	-1.7	-5.6	2.3e-08	0.04	0.02	0.74	FALSE
9	GTEx	Esophagus Muscularis	SEPT2	0.57	0.34	enet	34	0.48	1.7e-32	-4.2	-5.5	3.1e-08	0.02	0.33	0.59	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	SEPT2	0.66	0.38	enet	29	0.50	7.1e-21	-4.2	-5.5	3.2e-08	0.04	0.32	0.59	FALSE
4	GTEx	Brain Frontal Cortex BA9	SEPT2	0.30	-0.01	enet	32	0.02	1.1e-01	-4.2	-5.5	3.5e-08	0.00	0.06	0.08	FALSE
13	GTEx	Whole Blood	SEPT2	0.26	0.10	lasso	5	0.12	1.8e-11	-4.2	-5.4	5.1e-08	0.04	0.32	0.59	FALSE
6	GTEx	Cells Transformed fibroblasts	SEPT2	0.34	0.14	lasso	6	0.32	5.5e-25	-4.2	-5.4	5.2e-08	0.03	0.32	0.59	FALSE
11	GTEx	Muscle Skeletal	SEPT2	0.39	0.22	enet	46	0.26	1.0e-25	-4.2	-5.4	5.4e-08	0.01	0.32	0.59	FALSE
2	GTEx	Adipose Subcutaneous	SEPT2	0.45	0.36	enet	32	0.43	3.0e-38	-4.2	-5.4	6.3e-08	0.02	0.32	0.59	FALSE
12	GTEx	Vagina	SEPT2	0.50	0.02	enet	35	0.06	1.5e-02	-4.2	-5.4	6.3e-08	0.07	0.03	0.12	FALSE
5	GTEx	Breast Mammary Tissue	SEPT2	0.46	0.33	enet	37	0.35	5.2e-19	-4.2	-5.4	6.7e-08	0.04	0.32	0.59	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	SEPT2	0.48	0.39	enet	49	0.42	6.0e-58	-4.2	-5.3	1.1e-07	0.01	0.33	0.59	FALSE
10	GTEx	Heart Atrial Appendage	HDLBP	0.14	0.02	enet	15	0.07	4.3e-04	-3.9	5.1	2.9e-07	-0.04	0.15	0.46	FALSE