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chr3:11,350,553-13,402,150

Best TWAS P=4.94e-29 · Best GWAS P=4.38e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Cells EBV-transformed lymphocytes	PPARG	0.23	0.09	lasso	12	0.07	2.1e-03	-10.7	-11.2	4.9e-29	0.87	0.05	0.89	TRUE
5	GTEx	Artery Tibial	MKRN2	0.27	0.09	enet	20	0.25	3.1e-19	5.6	7.6	2.2e-14	-0.07	1.00	0.00	TRUE
14	GTEx	Esophagus Muscularis	TSEN2	0.12	0.03	enet	36	0.05	5.6e-04	6.3	-7.2	8.8e-13	0.29	0.09	0.26	TRUE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MKRN2	0.18	0.03	enet	9	0.05	1.8e-03	5.6	7.0	2.3e-12	-0.07	0.02	0.49	TRUE
20	GTEx	Muscle Skeletal	SYN2	0.18	0.10	enet	28	0.14	5.3e-14	-5.2	-6.9	4.0e-12	0.41	1.00	0.00	TRUE
6	GTEx	Artery Tibial	TSEN2	0.14	0.10	lasso	6	0.07	5.3e-06	6.5	-6.8	9.1e-12	0.12	1.00	0.00	TRUE
2	GTEx	Adipose Visceral Omentum	MKRN2	0.20	0.05	enet	11	0.09	1.7e-05	4.8	6.4	1.5e-10	-0.07	0.87	0.01	TRUE
16	GTEx	Heart Left Ventricle	MKRN2	0.21	0.05	enet	15	0.14	1.1e-07	4.8	6.2	5.2e-10	-0.11	0.94	0.00	TRUE
15	GTEx	Heart Atrial Appendage	MKRN2	0.14	0.09	lasso	3	0.08	1.5e-04	5.4	6.0	2.5e-09	-0.13	0.75	0.01	TRUE
13	GTEx	Esophagus Gastroesophageal Junction	MKRN2	0.17	0.10	enet	13	0.07	1.9e-03	6.3	5.5	3.9e-08	-0.11	0.28	0.06	TRUE
10	GTEx	Breast Mammary Tissue (Female)	TIMP4	0.40	0.00	lasso	12	0.06	5.7e-03	3.1	5.4	8.4e-08	-0.13	0.09	0.08	TRUE
17	GTEx	Heart Left Ventricle	PPARG	0.25	0.07	enet	36	0.10	5.1e-06	-7.7	-5.2	2.1e-07	0.34	0.64	0.08	TRUE
4	GTEx	Artery Aorta	TSEN2	0.11	0.01	enet	22	0.02	1.7e-02	-2.9	-9.1	1.5e-19	0.52	0.18	0.57	FALSE
22	NTR	Blood	TSEN2	0.02	0.00	bslmm	481	0.01	1.4e-03	5.6	-8.9	5.6e-19	0.27	0.29	0.04	FALSE
21	GTEx	Thyroid	MKRN2	0.11	0.04	enet	14	0.05	6.3e-05	6.4	8.3	1.3e-16	-0.13	0.86	0.03	FALSE
9	GTEx	Brain Cerebellum	PPARG	0.64	0.57	lasso	7	0.57	4.1e-20	-7.6	-7.9	2.9e-15	0.61	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIMP4	0.03	0.03	blup	32	0.02	1.4e-03	-8.3	-7.7	1.8e-14	0.45	0.00	0.91	FALSE
8	GTEx	Brain Cerebellar Hemisphere	PPARG	0.57	0.57	lasso	5	0.54	3.6e-16	-7.6	-7.5	4.9e-14	0.62	0.98	0.02	FALSE
26	YFS	Blood	TSEN2	0.14	0.10	enet	34	0.14	2.7e-44	-2.9	-7.3	3.3e-13	0.23	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	MKRN2	0.18	0.16	lasso	6	0.16	8.8e-12	5.7	6.5	1.0e-10	-0.05	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	MKRN2	0.22	0.14	lasso	4	0.14	1.5e-13	5.6	6.3	3.5e-10	-0.05	0.54	0.46	FALSE
19	GTEx	Muscle Skeletal	MKRN2	0.38	0.33	enet	14	0.39	1.7e-40	5.7	6.2	7.2e-10	-0.03	1.00	0.00	FALSE
18	GTEx	Lung	MKRN2	0.11	0.06	lasso	7	0.06	1.7e-05	5.6	6.1	1.1e-09	-0.04	0.86	0.00	FALSE
1	GTEx	Adipose Subcutaneous	MKRN2	0.13	0.04	enet	10	0.07	3.2e-06	5.6	6.1	1.4e-09	-0.03	0.89	0.00	FALSE
24	YFS	Blood	MKRN2	0.25	0.16	enet	16	0.18	7.2e-57	5.7	6.0	1.6e-09	-0.01	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MKRN2	0.20	0.13	lasso	3	0.12	8.8e-06	5.6	6.0	2.0e-09	-0.02	0.05	0.76	FALSE
25	YFS	Blood	RAF1	0.02	0.03	lasso	2	0.03	2.1e-10	5.8	5.9	3.1e-09	-0.13	1.00	0.00	FALSE
3	GTEx	Artery Aorta	MKRN2	0.30	0.07	enet	15	0.15	1.2e-08	6.4	5.9	4.3e-09	-0.06	0.98	0.00	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	TSEN2	0.09	0.03	blup	78	0.06	5.0e-07	6.3	-5.8	6.4e-09	0.16	0.01	0.98	FALSE
7	GTEx	Brain Caudate basal ganglia	MKRN2	0.38	0.01	lasso	9	0.04	3.3e-02	-5.2	5.7	1.3e-08	-0.07	0.11	0.09	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MKRN2	0.07	0.04	lasso	2	0.03	3.4e-04	5.6	5.7	1.4e-08	-0.03	0.11	0.51	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	MKRN2	0.10	0.07	lasso	1	0.06	1.9e-04	5.6	5.6	1.9e-08	-0.02	0.05	0.22	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	MKRN2	0.17	0.10	lasso	3	0.09	3.6e-10	5.6	5.5	4.9e-08	-0.01	0.54	0.46	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MKRN2	0.14	0.09	lasso	4	0.14	1.9e-15	5.6	5.2	1.8e-07	-0.02	0.22	0.78	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	MKRN2	0.16	0.05	lasso	10	0.08	1.8e-10	3.4	5.2	2.1e-07	0.00	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TSEN2	0.06	0.00	enet	18	0.03	6.2e-03	6.5	-5.2	2.2e-07	0.14	0.02	0.42	FALSE