Best TWAS P=2.36e-11 · Best GWAS P=1.13e-10 conditioned to 0.44
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | AP2M1 | 0.20 | 0.06 | enet | 32 | 0.08 | 8.2e-07 | 5.4 | 5.6 | 2.4e-08 | 0.33 | 0.81 | 0.14 | FALSE |
| 2 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | -5.1 | 5.3 | 9.9e-08 | 0.52 | 0.78 | 0.13 | FALSE |
| 3 | GTEx | Brain Cerebellum | ABCC5 | 0.18 | 0.18 | lasso | 5 | 0.13 | 1.4e-04 | -5.6 | -5.5 | 4.2e-08 | -0.21 | 0.23 | 0.36 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ABCC5 | 0.13 | 0.10 | lasso | 5 | 0.09 | 1.8e-06 | 6.2 | 6.2 | 6.3e-10 | 0.27 | 0.07 | 0.93 | FALSE |
| 5 | GTEx | Heart Left Ventricle | AP2M1 | 0.10 | 0.06 | enet | 15 | 0.03 | 9.7e-03 | 5.4 | 5.7 | 1.0e-08 | 0.41 | 0.60 | 0.11 | FALSE |
| 6 | GTEx | Muscle Skeletal | ABCF3 | 0.10 | 0.07 | lasso | 4 | 0.09 | 3.7e-09 | 4.7 | 5.2 | 1.9e-07 | 0.37 | 0.98 | 0.02 | FALSE |
| 7 | NTR | Blood | ABCC5 | 0.08 | 0.11 | enet | 26 | 0.11 | 6.8e-33 | -5.6 | 5.8 | 7.5e-09 | 0.24 | 0.51 | 0.49 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABCC5 | 0.05 | 0.04 | enet | 8 | 0.03 | 7.0e-04 | 5.9 | 6.3 | 2.8e-10 | 0.20 | 0.03 | 0.94 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 5.2 | 6.7 | 2.4e-11 | 0.70 | 0.03 | 0.94 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | 4.4 | -6.3 | 3.4e-10 | -0.44 | 0.04 | 0.23 | FALSE |