Best TWAS P=1.66e-08 · Best GWAS P=1.33e-08 conditioned to 0.0125
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | RPA2 | 0.17 | 0.08 | lasso | 7 | 0.08 | 4.1e-05 | -5.3 | -5.2 | 2.3e-07 | 0.62 | 0.11 | 0.83 | FALSE |
2 | GTEx | Breast Mammary Tissue | RPA2 | 0.13 | 0.02 | lasso | 4 | 0.04 | 2.4e-03 | -5.3 | -5.3 | 1.3e-07 | 0.70 | 0.07 | 0.50 | FALSE |
3 | GTEx | Colon Sigmoid | RP5-1092A3.4 | 0.20 | 0.09 | lasso | 4 | 0.08 | 6.4e-04 | 5.3 | -5.2 | 1.6e-07 | 0.14 | 0.12 | 0.67 | FALSE |
4 | GTEx | Colon Transverse | RPA2 | 0.12 | 0.09 | lasso | 2 | 0.04 | 6.9e-03 | -5.3 | -5.3 | 1.2e-07 | 0.61 | 0.03 | 0.85 | FALSE |
5 | GTEx | Esophagus Muscularis | RPA2 | 0.16 | 0.17 | lasso | 5 | 0.17 | 2.4e-10 | -5.3 | -5.2 | 1.9e-07 | 0.62 | 0.09 | 0.91 | FALSE |
6 | GTEx | Lung | RPA2 | 0.12 | 0.08 | lasso | 4 | 0.08 | 1.5e-06 | -5.3 | -5.3 | 1.4e-07 | 0.63 | 0.11 | 0.87 | FALSE |
7 | GTEx | Pituitary | RP5-1092A3.4 | 0.55 | 0.31 | lasso | 7 | 0.31 | 1.2e-08 | 4.7 | -5.3 | 1.4e-07 | 0.15 | 0.44 | 0.52 | TRUE |
8 | GTEx | Thyroid | RPA2 | 0.09 | 0.10 | enet | 19 | 0.11 | 1.8e-08 | -5.3 | -5.6 | 1.7e-08 | 0.49 | 0.09 | 0.90 | TRUE |
9 | GTEx | Whole Blood | RPA2 | 0.16 | 0.10 | enet | 13 | 0.08 | 1.2e-07 | -5.3 | -5.6 | 2.4e-08 | 0.61 | 0.07 | 0.93 | FALSE |
10 | NTR | Blood | ATPIF1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 2.5e-08 | 5.2 | -5.2 | 2.0e-07 | 0.14 | 0.14 | 0.86 | FALSE |
11 | NTR | Blood | RPA2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 9.0e-27 | -5.6 | 5.5 | 4.0e-08 | -0.44 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C1orf38 | 0.03 | 0.01 | blup | 35 | 0.02 | 1.7e-03 | -5.4 | 5.2 | 1.9e-07 | -0.38 | 0.02 | 0.97 | FALSE |