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chr1:23,011,971-26,895,802

Best TWAS P=2.48e-15 · Best GWAS P=1.35e-19 conditioned to 2.63e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PITHD1	0.05	0.04	enet	8	0.05	7.9e-05	-6.4	6.6	3.8e-11	0.05	0.83	0.01	FALSE
2	GTEx	Adipose Subcutaneous	ASAP3	0.09	0.07	lasso	3	0.06	6.2e-06	-5.6	5.2	1.8e-07	-0.31	0.66	0.02	FALSE
3	GTEx	Adrenal Gland	MTFR1L	0.22	0.09	enet	16	0.10	1.9e-04	-3.0	-5.7	9.4e-09	-0.11	0.18	0.80	FALSE
4	GTEx	Artery Aorta	MTFR1L	0.10	0.08	lasso	4	0.06	3.0e-04	-5.3	-5.3	1.4e-07	-0.08	0.89	0.01	FALSE
5	GTEx	Artery Tibial	PITHD1	0.09	0.10	lasso	4	0.10	5.3e-08	-6.6	6.5	5.8e-11	0.05	1.00	0.00	FALSE
6	GTEx	Artery Tibial	MTFR1L	0.14	0.13	lasso	9	0.12	7.8e-10	-5.3	-5.2	1.5e-07	-0.08	1.00	0.00	FALSE
7	GTEx	Artery Tibial	RP3-465N24.5	0.38	0.09	enet	32	0.15	5.1e-12	-3.0	-5.4	5.4e-08	0.11	0.99	0.00	FALSE
8	GTEx	Artery Tibial	RP1-317E23.7	0.08	0.10	enet	15	0.10	6.4e-08	-5.3	-5.3	1.4e-07	-0.08	1.00	0.00	FALSE
9	GTEx	Brain Cerebellum	SEPN1	0.36	0.23	lasso	12	0.26	3.3e-08	-5.3	-6.1	1.4e-09	-0.08	0.37	0.52	FALSE
10	GTEx	Brain Cortex	HMGCL	0.22	0.09	enet	12	0.12	3.2e-04	-4.5	-5.3	9.7e-08	-0.08	0.23	0.07	FALSE
11	GTEx	Brain Cortex	TCEA3	0.51	0.36	lasso	2	0.35	1.8e-10	-5.3	5.3	1.0e-07	-0.34	0.86	0.07	FALSE
12	GTEx	Brain Frontal Cortex BA9	TCEA3	0.35	0.24	lasso	6	0.25	2.5e-07	-5.3	6.1	1.0e-09	-0.45	0.08	0.78	FALSE
13	GTEx	Breast Mammary Tissue	MTFR1L	0.12	0.07	enet	14	0.04	3.0e-03	-7.0	6.6	4.2e-11	0.03	0.15	0.79	FALSE
14	GTEx	Cells Transformed fibroblasts	ASAP3	0.14	0.11	lasso	4	0.11	1.3e-08	-5.6	5.5	2.8e-08	-0.36	0.99	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	SEPN1	0.10	0.07	lasso	7	0.06	3.1e-05	-6.6	-6.5	5.6e-11	0.01	0.06	0.94	FALSE
16	GTEx	Cells Transformed fibroblasts	TCEA3	0.33	0.19	lasso	4	0.22	2.6e-16	-5.3	6.8	1.1e-11	-0.44	1.00	0.00	TRUE
17	GTEx	Colon Transverse	MTFR1L	0.21	0.29	enet	20	0.27	2.8e-13	-7.8	7.5	8.4e-14	0.02	0.00	1.00	FALSE
18	GTEx	Colon Transverse	RP1-317E23.7	0.23	0.29	enet	15	0.32	1.0e-15	-7.0	7.2	6.5e-13	0.03	0.03	0.97	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	MTFR1L	0.09	0.13	lasso	3	0.11	1.2e-04	-7.0	6.7	1.7e-11	0.05	0.04	0.91	FALSE
20	GTEx	Esophagus Mucosa	MTFR1L	0.25	0.17	enet	16	0.15	3.3e-10	-7.4	7.7	1.3e-14	0.02	0.01	0.99	FALSE
21	GTEx	Esophagus Mucosa	RP1-317E23.7	0.21	0.20	enet	11	0.17	3.3e-11	-7.4	7.0	1.9e-12	0.00	0.04	0.96	FALSE
22	GTEx	Esophagus Muscularis	MTFR1L	0.24	0.20	enet	14	0.20	3.7e-12	-7.0	7.0	2.4e-12	0.02	0.09	0.91	FALSE
23	GTEx	Esophagus Muscularis	RP1-317E23.7	0.27	0.15	enet	15	0.15	2.9e-09	-7.4	7.0	3.5e-12	0.01	0.02	0.98	FALSE
24	GTEx	Heart Atrial Appendage	MTFR1L	0.20	0.28	enet	15	0.24	4.3e-11	-7.5	6.7	1.8e-11	0.02	0.01	0.99	FALSE
25	GTEx	Heart Atrial Appendage	RP1-317E23.7	0.23	0.31	enet	15	0.25	1.6e-11	-7.5	6.8	1.5e-11	0.02	0.01	0.99	FALSE
26	GTEx	Heart Left Ventricle	MTFR1L	0.41	0.37	enet	16	0.39	6.9e-22	-7.4	7.5	5.9e-14	0.03	0.01	0.99	FALSE
27	GTEx	Heart Left Ventricle	FUCA1	0.16	0.20	lasso	3	0.21	3.2e-11	-6.6	6.7	2.9e-11	0.04	1.00	0.00	FALSE
28	GTEx	Heart Left Ventricle	RP1-317E23.7	0.32	0.29	enet	13	0.29	7.8e-16	-7.4	7.5	6.9e-14	0.03	0.01	0.99	FALSE
29	GTEx	Liver	HMGCL	0.27	0.04	lasso	4	0.02	8.2e-02	-6.6	5.4	6.0e-08	0.07	0.09	0.05	FALSE
30	GTEx	Muscle Skeletal	ASAP3	0.25	0.17	lasso	3	0.18	4.5e-17	-5.6	6.0	1.4e-09	-0.38	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	HMGCL	0.08	0.07	lasso	4	0.06	2.6e-06	-6.6	-6.4	2.0e-10	-0.05	1.00	0.00	FALSE
32	GTEx	Muscle Skeletal	MTFR1L	0.25	0.28	lasso	9	0.31	1.3e-30	-7.4	7.4	1.4e-13	0.02	0.01	0.99	FALSE
33	GTEx	Muscle Skeletal	SEPN1	0.14	0.17	lasso	4	0.17	1.1e-16	-5.3	-5.1	2.9e-07	-0.09	1.00	0.00	FALSE
34	GTEx	Muscle Skeletal	RP3-465N24.5	0.10	0.04	enet	26	0.08	1.2e-08	-3.0	-6.1	1.0e-09	0.06	0.51	0.02	TRUE
35	GTEx	Muscle Skeletal	RP1-317E23.7	0.22	0.22	lasso	10	0.26	3.9e-25	-7.4	7.2	5.7e-13	0.01	0.00	1.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	MTFR1L	0.12	0.05	enet	24	0.05	3.8e-05	-7.7	7.4	1.2e-13	0.07	0.01	0.98	FALSE
37	GTEx	Small Intestine Terminal Ileum	RP1-317E23.7	0.15	0.14	lasso	1	0.07	1.0e-02	-6.3	6.3	2.2e-10	0.04	0.03	0.72	FALSE
38	GTEx	Testis	MTFR1L	0.61	0.50	enet	27	0.58	2.5e-31	-3.9	5.3	1.4e-07	-0.01	1.00	0.00	FALSE
39	GTEx	Testis	RP1-317E23.3	0.18	0.02	enet	26	0.08	2.2e-04	6.6	6.8	8.8e-12	0.01	0.07	0.89	FALSE
40	GTEx	Testis	RP1-317E23.7	0.59	0.52	enet	20	0.58	4.6e-31	-3.9	5.3	9.9e-08	-0.02	1.00	0.00	FALSE
41	GTEx	Thyroid	ASAP3	0.31	0.19	lasso	2	0.19	2.5e-14	-5.3	5.3	1.3e-07	-0.35	1.00	0.00	FALSE
42	GTEx	Thyroid	HMGCL	0.10	0.10	lasso	1	0.09	2.5e-07	-6.6	-6.6	5.4e-11	-0.04	1.00	0.00	FALSE
43	GTEx	Thyroid	MTFR1L	0.28	0.21	enet	19	0.23	1.3e-17	-7.4	7.4	1.1e-13	0.03	0.02	0.98	FALSE
44	GTEx	Thyroid	RP1-317E23.7	0.23	0.25	lasso	4	0.22	1.0e-16	-7.4	7.4	1.9e-13	0.02	0.02	0.98	FALSE
45	GTEx	Whole Blood	TCEB3	0.05	0.02	lasso	3	0.01	8.0e-02	-6.5	5.5	3.3e-08	0.02	0.17	0.21	FALSE
46	GTEx	Whole Blood	RP3-465N24.5	0.48	0.11	enet	35	0.24	2.8e-22	-3.0	-5.2	1.6e-07	0.10	1.00	0.00	FALSE
47	METSIM	Adipose	CLIC4	0.05	0.03	lasso	3	0.04	3.9e-06	4.3	6.2	7.3e-10	0.02	0.10	0.89	FALSE
48	METSIM	Adipose	TCEB3	0.03	0.02	blup	340	0.01	2.4e-03	-6.0	6.4	1.6e-10	-0.02	0.82	0.00	FALSE
49	NTR	Blood	CLIC4	0.03	0.02	lasso	6	0.02	1.4e-06	6.7	6.4	1.9e-10	-0.01	0.06	0.94	TRUE
50	NTR	Blood	CNR2	0.04	0.05	lasso	11	0.05	5.4e-15	-6.8	-6.7	2.9e-11	-0.04	1.00	0.00	FALSE
51	NTR	Blood	FUCA1	0.05	0.07	lasso	13	0.06	4.2e-20	-6.8	6.9	3.9e-12	0.04	1.00	0.00	TRUE
52	NTR	Blood	PAQR7	0.01	0.00	blup	400	0.01	7.0e-04	-7.7	5.9	3.6e-09	0.06	0.02	0.91	FALSE
53	NTR	Blood	TCEB3	0.02	0.02	lasso	3	0.02	2.2e-06	-6.0	6.3	2.4e-10	0.03	0.99	0.00	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	HMGCL	0.15	0.22	enet	19	0.23	1.2e-28	-6.6	-6.2	5.8e-10	-0.04	1.00	0.00	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	NCMAP	0.08	0.02	lasso	3	0.03	4.3e-05	-3.9	5.9	3.8e-09	0.03	0.80	0.04	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	TCEA3	0.41	0.36	enet	23	0.37	5.1e-50	-5.3	5.3	9.3e-08	-0.32	1.00	0.00	FALSE
57	YFS	Blood	FUCA1	0.17	0.29	bslmm	354	0.30	4.0e-102	-6.9	6.5	1.0e-10	0.08	1.00	0.00	FALSE
58	YFS	Blood	ID3	0.07	0.02	lasso	10	0.04	8.4e-13	3.9	6.6	5.0e-11	-0.73	0.56	0.44	FALSE
59	YFS	Blood	TCEA3	0.17	0.17	lasso	10	0.20	4.4e-62	-5.3	5.7	1.1e-08	-0.32	1.00	0.00	FALSE
60	YFS	Blood	TCEB3	0.06	0.07	lasso	2	0.07	2.2e-22	-6.0	6.0	2.0e-09	0.02	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FAM54B	0.02	0.02	lasso	7	0.02	9.9e-03	-5.3	-5.3	1.3e-07	-0.08	0.14	0.11	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUCA1	0.01	0.01	blup	35	0.01	1.6e-02	-6.6	-6.8	1.2e-11	-0.02	0.02	0.67	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	CLIC4	0.04	0.04	blup	65	0.02	1.7e-02	5.6	-5.9	4.0e-09	0.02	0.04	0.28	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM54B	0.14	0.03	blup	63	0.09	8.5e-06	-4.1	5.9	3.8e-09	-0.02	0.02	0.93	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC646471	0.09	0.12	lasso	4	0.11	1.0e-06	-7.5	7.5	8.5e-14	0.03	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Esophageal Carcinoma	LOC646471	0.13	0.09	enet	6	0.11	2.2e-04	-7.4	7.0	3.0e-12	0.06	0.01	0.97	FALSE
67	The Cancer Genome Atlas	Glioblastoma Multiforme	C1orf128	0.10	0.03	enet	7	0.05	1.4e-02	3.4	5.6	1.9e-08	0.07	0.01	0.57	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM54B	0.08	0.07	enet	5	0.08	6.0e-09	-3.9	6.2	6.3e-10	-0.01	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC646471	0.10	0.11	blup	60	0.10	1.6e-11	-7.8	7.8	4.4e-15	0.03	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM54B	0.20	0.15	enet	14	0.14	1.2e-08	-3.9	5.8	6.5e-09	-0.02	0.12	0.88	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC646471	0.11	0.10	enet	5	0.09	7.4e-06	-7.5	7.5	6.5e-14	0.03	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM54B	0.09	0.16	enet	16	0.15	5.1e-17	-5.3	-5.2	2.4e-07	-0.08	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LOC646471	0.06	0.07	lasso	2	0.07	5.2e-04	-7.4	7.4	9.9e-14	0.03	0.01	0.94	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ASAP3	0.03	0.02	blup	49	0.01	7.9e-03	-8.2	6.6	4.1e-11	-0.69	0.01	0.70	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMGCL	0.03	0.00	blup	41	0.01	1.1e-02	-3.8	-6.2	4.0e-10	-0.01	0.02	0.35	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC646471	0.09	0.02	blup	60	0.05	1.6e-04	-7.7	6.2	7.2e-10	-0.01	0.01	0.91	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASAP3	0.10	0.10	enet	11	0.11	1.1e-11	-5.6	6.0	1.7e-09	-0.44	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf130	0.05	0.01	blup	59	0.03	1.0e-03	2.5	5.6	1.8e-08	0.04	0.01	0.68	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	PAQR7	0.02	0.02	blup	58	0.01	2.1e-02	-7.5	7.4	1.1e-13	0.06	0.02	0.80	FALSE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC646471	0.12	0.14	blup	60	0.14	2.7e-10	-7.5	7.9	2.5e-15	0.05	0.01	0.99	TRUE