TWAS hub - C1orf38

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0755	0.0190	2.3e-14	0.063	0.050	0.069	0.06	0.067	2.0e-19	7.6e-16	2.1e-21	1.2e-18	1.1e-20
2	TCGA	Breast Invasive Carcinoma	0.0492	0.0220	1.3e-07	0.034	0.036	0.032	NA	0.037	1.5e-07	5.0e-08	3.3e-07	NA	4.5e-08
3	TCGA	Glioblastoma Multiforme	0.2500	0.1150	9.4e-03	-0.005	0.016	-0.006	NA	-0.010	5.1e-01	1.0e-01	5.4e-01	NA	9.3e-01
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0269	0.0164	6.1e-04	0.011	0.021	0.014	NA	0.017	1.7e-02	1.7e-03	8.7e-03	NA	4.4e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0380	0.0214	1.2e-03	0.019	0.027	0.016	NA	0.014	3.1e-03	4.2e-04	5.3e-03	NA	9.8e-03
6	TCGA	Lung Adenocarcinoma	0.0365	0.0190	8.5e-05	0.020	0.032	0.029	NA	0.025	2.1e-03	1.0e-04	2.1e-04	NA	5.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	6.7	77.8	118.8	9.8	8.8	-2.9	10.9	8.5	9.7
Reason for reducing amount of alcohol drunk: Health precaution	6.2	7.2	10.8	3.0	3.0	1.5	1.9	3.3	3.0
Blood White Count	5.0	36.7	60.5	6.6	5.9	-2.4	7.8	5.4	6.9
Exposure to tobacco smoke at home	3.9	4.4	6.6	1.6	2.4	2.2	0.8	2.6	2.4
Blood Eosinophil Count	3.6	28.0	38.8	6.2	5.2	-1.2	6.2	5.4	5.7
HbA1C	3.5	3.9	5.4	2.2	1.8	-0.4	2.2	2.3	2.2
Diabetes (mother)	3.4	4.4	7.7	2.5	2.0	-1.1	2.8	1.9	1.9
High blood pressure (mother)	3.2	4.5	7.0	2.6	2.4	0.6	2.0	2.3	2.3
Emphysema/chronic bronchitis	3.1	3.5	12.1	-0.9	1.1	3.5	-2.6	0.4	-0.6
Taking other prescription medications	2.9	4.5	6.9	2.2	2.6	0.3	1.9	2.3	2.5
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	7.5	1.6	1.8	2.7	-0.4	1.9	1.2
Family relationship satisfaction	2.9	3.5	5.5	1.7	2.0	0.9	1.7	2.4	2.3
Health satisfaction	2.8	3.7	6.8	1.3	1.8	2.3	0.5	2.6	2.2
Medication: Co-codamol	2.7	3.1	4.8	1.8	1.8	0.0	1.8	2.2	1.9
Had major operations	2.7	3.2	5.7	1.7	1.7	0.4	2.0	1.9	2.4
Supplements: Vitamin C	2.7	3.2	6.8	1.5	1.3	-0.8	2.6	1.7	2.2
Medication: Paracetamol	2.6	4.3	5.9	1.9	2.3	-0.1	2.3	2.4	2.3
High blood pressure (siblings)	2.6	3.7	5.4	2.1	2.1	-1.1	2.3	1.7	2.0
Osteoarthritis (self-reported)	2.5	3.2	5.9	1.5	1.7	1.6	1.0	2.4	2.1
Crohns Disease (2017)	2.3	5.0	6.8	2.5	2.4	0.4	2.2	2.6	2.5
LDL Cholesterol	2.3	3.7	6.1	-2.5	-1.9	-1.1	-1.8	-1.8	-2.3
Illnesses of siblings	2.3	3.2	5.9	-2.4	-2.3	-0.3	-1.4	-1.7	-1.8
Ever had prostate specific antigen (PSA) test	2.3	2.6	4.9	2.2	1.7	0.4	1.3	1.9	1.6
Vascular/heart problems diagnosed by doctor	2.3	6.3	16.0	-2.1	-1.1	2.9	-4.0	-1.6	-2.3
Cardiovascular Disease	2.2	7.4	13.4	3.1	2.2	-1.1	3.7	2.6	2.8
Hair/balding pattern: Pattern 3	2.2	3.2	4.4	2.0	1.9	-0.2	2.0	1.8	2.1
Knee pain experienced in last month	2.2	3.5	4.7	2.1	2.2	1.1	1.4	2.2	2.0
High blood pressure	2.1	6.0	15.3	2.1	1.1	-2.7	3.9	1.6	2.3
Medication: Omeprazole	2.0	2.3	3.9	1.1	1.9	1.0	0.9	1.9	2.0
Number of full brothers	1.9	2.4	4.1	-1.6	-2.0	-0.9	-1.2	-1.6	-1.7
Medication: Ibuprofen	1.9	2.3	4.5	0.8	1.7	2.1	-0.0	1.8	1.6
Number of full sisters	1.9	2.3	5.6	-1.3	-0.8	1.3	-2.4	-1.2	-1.7
Hypertension (Self-reported)	1.9	5.3	13.9	1.9	0.9	-2.7	3.7	1.4	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	6.4	-2.4	-2.5	-1.0	-1.4	-2.1	-2.0
Irritable Bowel Disease (IBD)	1.8	4.3	6.2	2.0	2.3	0.7	1.9	2.5	2.5
Lung FVC	1.8	9.1	14.6	-3.0	-2.8	0.9	-3.8	-3.1	-3.6
Illnesses of siblings: Diabetes	1.8	2.2	4.2	2.0	2.0	0.9	0.4	1.7	1.0
Pain type(s) experienced in last month: Hip pain	1.8	2.3	3.8	1.4	1.7	0.4	1.3	2.0	1.7
Average weekly beer plus cider intake	1.8	2.7	4.0	1.8	1.5	0.5	1.6	2.0	1.9
Medication for pain relief, constipation, heartburn	1.7	2.9	4.2	-1.5	-1.9	0.4	-2.0	-1.9	-2.0
Medication: Blood pressure	1.7	3.0	8.0	1.6	0.5	-2.4	2.8	0.5	1.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.2	1.0	2.0	1.0	0.7	1.7	1.7
Number of treatments/medications taken	1.6	2.9	5.0	1.6	1.5	-1.2	2.2	1.8	1.7
Maternal smoking around birth	1.6	2.3	7.3	0.5	0.4	2.7	-2.2	-0.1	-1.0
Serious illness, injury or assault to yourself	1.6	2.0	4.4	-2.1	-1.3	-0.3	-1.4	-1.4	-1.3
Worrier / anxious feelings	1.6	3.1	4.8	1.7	2.1	1.1	1.2	2.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.0	1.6	1.7	1.1	0.7	1.3	1.5
Medication: Lisinopril	1.6	2.1	6.6	0.8	-0.1	-2.6	2.3	0.3	0.6
Bipolar Disorder (2011)	1.5	1.5	3.5	0.0	0.0	0.6	1.5	1.6	1.9
Systolic Blood Pressure	1.5	7.7	12.0	3.0	2.8	-1.3	3.5	2.5	3.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	5.2	2.2	1.9	0.0	1.8	2.1	2.3
Pulse wave Arterial Stiffness index	1.5	1.8	7.8	-0.5	-0.6	-2.8	1.3	-0.7	-0.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.7	1.7	1.0	-0.9	1.9	1.1	1.1
Body Mass Index (BMI) (2010)	1.4	1.9	3.1	1.8	1.3	-0.2	1.6	1.3	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	4.8	2.2	1.7	-0.1	1.9	2.0	2.1
Pulse wave peak to peak time	1.4	1.7	7.2	0.5	0.6	2.7	-1.3	0.7	0.2
Shortness of breath walking on level ground	1.4	1.7	3.3	0.9	1.8	1.1	0.3	1.7	1.4
Medication: Seretide 50 evohaler	1.4	1.6	5.8	0.4	1.2	2.4	-1.3	0.6	0.2
Vitamin and mineral supplements	1.3	1.8	6.6	-0.1	0.6	2.6	-1.8	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.3	-1.3	-1.8	-1.5	-0.2	-1.8	-1.4
Medication: Paracetamol	1.3	2.1	3.3	1.0	1.8	-0.0	1.5	1.8	1.6
Blood Red Count	1.2	11.2	27.1	3.3	1.5	-2.7	5.2	2.2	3.8
Hearing difficulty/problems: Yes	1.2	1.8	3.5	1.4	1.0	1.0	0.8	1.9	1.5
Medication: Metformin	1.2	1.7	5.5	0.3	-0.8	-2.3	1.9	0.1	0.6
Multivitamins +/- minerals	1.2	1.6	4.4	-0.9	-1.7	-2.1	0.4	-0.9	-0.6
Alcohol intake versus 10 years previously	1.2	1.8	5.9	0.2	-1.5	-2.4	1.6	-0.0	0.2
Noisy workplace	1.2	1.4	4.0	-0.9	-0.6	1.4	-2.0	-0.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.2	0.7	1.2	2.1	-0.2	1.4	1.1
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	5.0	-1.1	-0.2	2.2	-2.2	-0.3	-0.7
Exposure to tobacco smoke outside home	1.2	1.7	3.6	1.9	1.0	0.6	1.1	1.3	1.4
Alcohol intake frequency.	1.2	2.7	8.1	1.1	0.1	-2.8	2.5	0.3	0.7
Medication: Aspirin	1.2	1.6	3.6	0.8	0.8	-1.3	1.9	1.0	1.4
Medication for hormone replacement therapy	1.1	1.2	2.1	-1.3	-0.6	0.5	-1.5	-1.2	-1.1
Medication: Lansoprazole	1.1	1.3	2.5	1.1	1.6	0.8	0.4	1.2	1.3
Breastfed as a baby	1.1	1.3	2.6	-0.8	-1.3	-0.4	-1.2	-1.3	-1.6
Blood clot in the leg (DVT)	1.1	1.4	2.5	-1.6	-1.3	1.0	-1.4	-0.8	-0.9
Comparative body size at age 10	1.1	3.2	4.6	1.6	1.9	0.1	1.9	2.1	2.1
Chest pain or discomfort	1.1	1.6	2.9	1.7	1.6	0.6	0.7	1.5	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.3	1.3	1.2	0.5	0.7	1.5	1.3
Back pain experienced in last month	1.1	1.6	3.8	-1.3	-0.7	0.8	-1.9	-1.0	-1.4
Average weekly champagne plus white wine intake	1.1	1.5	4.0	-1.3	-0.6	0.5	-2.0	-1.0	-1.5
Medication: Bendroflumethiazide	1.1	1.6	4.4	0.9	0.0	-2.0	2.1	0.3	0.8
Illnesses of father: High blood pressure	1.1	1.4	2.7	0.6	1.1	-0.1	1.6	1.2	1.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.4	-1.6	-1.4	1.0	-1.4	-0.7	-1.0
Medication: Levothyroxine sodium	1.0	1.7	3.1	-1.0	-1.6	-1.8	-0.2	-1.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.0	-1.3	-1.1	0.4	-1.4	-0.9	-1.1
Illnesses of mother	1.0	1.2	2.4	-1.1	-1.5	-1.3	0.0	-1.1	-0.9
Wheeze or whistling in the chest in last year	1.0	1.7	2.2	1.4	1.4	0.1	1.4	1.5	1.5
Pulse rate, automated reading	1.0	3.2	5.5	-1.8	-1.6	0.7	-2.3	-2.1	-1.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.2	-0.4	-1.1	1.2	-1.5	-0.9	-1.1
Qualifications: nursing, teaching	1.0	1.5	3.9	0.8	0.0	-1.9	2.0	0.5	0.9
Ever smoked	1.0	1.7	4.7	-1.6	-1.1	-2.2	0.1	-1.0	-0.9
Ulcerative Colitis (UC)	0.9	1.7	2.9	1.1	1.6	0.6	1.2	1.4	1.7
Breast Cancer	0.9	2.2	3.4	-1.5	-1.4	0.0	-1.8	-1.6	-1.8
Heel T-Score	0.9	7.4	11.4	3.1	2.1	-0.7	3.4	2.8	3.2
Townsend deprivation index at recruitment	0.9	1.2	2.9	-0.7	-1.4	1.0	-1.7	-0.5	-0.9
Heart attack	0.9	1.1	3.1	0.1	-0.8	-1.8	0.3	-1.4	-1.1
Medication: Cholesterol lowering	0.9	1.4	5.1	0.4	-0.2	-2.2	1.6	0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	4.6	-1.7	-2.1	-1.0	-1.0	-2.1	-1.6
High cholesterol (Self-reported)	0.9	1.7	3.3	1.8	1.3	-0.2	1.5	1.2	1.2
Medication: Atorvastatin	0.9	1.1	3.9	0.6	0.0	-2.0	1.4	-0.6	-0.1
Schizophrenia vs Biploar Disorder	0.8	1.1	1.4	-1.2	-1.2	-0.4	-1.0	-1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.5	1.6	0.5	-0.9	2.1	1.3	1.5
Pack years adult smoking proportion	0.8	1.2	2.6	-0.5	-0.5	1.2	-1.6	-0.9	-1.2
Qualifications: CSEs or equivalent	0.8	1.1	2.4	-1.2	-1.5	-0.1	-0.8	-1.0	-1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.3	-1.2	-1.2	-0.6	-1.2	-1.8	-1.5
Allergy	0.8	1.8	2.8	1.3	1.3	0.6	1.2	1.7	1.6
Pulse wave reflection index	0.8	1.0	1.9	-0.8	-0.9	-1.4	-0.1	-1.2	-1.1
Age at first live birth	0.8	1.5	4.6	-0.8	-1.4	-2.1	1.0	-0.9	-0.1
Medication: Aspirin	0.8	1.1	2.9	0.5	0.2	-1.7	1.7	0.4	0.8
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	0.7	1.6	0.5	0.4	0.9	1.1
Medication: Blood pressure	0.8	1.6	3.4	1.3	0.8	-0.8	1.9	1.1	1.3
Cholesterol lowering medication	0.8	1.1	2.0	1.4	1.2	0.6	0.9	1.0	1.1
Heart disease (siblings)	0.8	1.0	2.3	1.5	0.9	0.2	0.8	1.1	1.0
Crohns Disease (2012)	0.7	1.1	1.6	1.2	1.2	-0.1	1.0	1.0	1.2
HDL Cholesterol	0.7	1.2	1.8	-1.1	-1.3	-1.0	-0.5	-1.2	-1.2
Rheumatoid Arthritis	0.7	1.0	1.7	-1.3	-0.9	-0.1	-1.0	-1.1	-1.1
Systolic blood pressure, automated reading	0.7	1.9	2.5	1.5	1.6	-0.5	1.6	1.4	1.5
Severe depression (siblings)	0.7	0.8	1.4	0.5	1.1	0.1	0.7	1.2	1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.7	-0.8	-0.1	0.6	-1.3	-0.9	-1.1
Forced vital capacity (FVC)	0.7	2.6	3.9	-1.5	-1.7	0.4	-1.8	-2.0	-1.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.8	-1.0	-1.5	-1.7	-0.0	-1.3	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.5	3.9	-1.6	-1.9	-0.2	-1.5	-2.0	-1.6
Migraine (self-reported)	0.7	0.9	1.5	1.2	1.2	1.2	-0.0	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	0.6	0.8	-0.3	1.1	1.2	1.0
Breast cancer (self-reported)	0.7	0.8	2.5	-0.0	0.1	-0.1	1.3	1.0	1.6
Depression (Nagel 2018)	0.6	0.9	2.2	-1.5	-0.7	0.1	-0.8	-1.2	-0.7
Alzheimer’s Disease (in father)	0.6	0.7	1.8	-1.0	-0.7	-1.3	0.4	-0.5	-0.3
Lupus	0.6	0.9	1.8	1.4	1.0	1.0	0.4	1.0	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	-0.6	-1.6	-1.6	0.2	-1.0	-0.7
Average weekly spirits intake	0.6	0.7	1.4	-1.0	-0.6	0.4	-1.2	-0.7	-0.9
Past tobacco smoking	0.6	1.2	3.7	1.2	0.8	1.9	-0.2	0.7	0.8
Pain all over the body in last month	0.6	0.7	1.3	0.2	0.6	0.9	0.5	1.1	1.1
Medication: Ramipril	0.6	0.8	1.9	0.8	0.3	-1.1	1.4	0.6	0.6
Worry too long after embarrassment	0.6	1.1	1.6	1.3	1.1	-0.6	1.3	0.9	0.9
Friendships satisfaction	0.6	0.8	2.0	0.7	0.8	1.4	0.1	1.1	0.6
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	1.0	0.5	-1.0	1.6	0.7	1.0
Mother’s age at death	0.6	0.8	2.0	0.1	1.0	0.5	0.7	1.0	1.4
Number of operations (self-reported)	0.6	0.9	2.2	1.1	0.6	-0.6	1.5	0.7	1.0
Pain experienced in last month	0.6	1.0	1.6	-0.8	-1.3	-0.0	-1.0	-1.1	-1.2
Supplements: Calcium	0.6	0.7	1.9	0.6	1.4	0.4	0.6	0.5	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	0.3	-0.4	-1.5	0.5	-1.1	-0.7
Hypothyroidism (self reported)	0.5	1.2	2.3	-0.8	-1.5	-1.5	0.1	-1.1	-0.6
Angina	0.5	0.6	2.7	-0.2	-0.4	-1.7	0.9	-0.2	-0.1
Supplements: Zinc	0.5	0.5	0.8	0.5	0.8	0.8	0.1	0.8	0.9
Diabetes (father)	0.5	0.6	1.8	-1.3	-0.2	-0.5	-1.0	-0.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	-0.7	0.3	1.3	-1.2	-0.3	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.3	1.1	0.9	0.7	0.4	1.2	1.0
Mouth/teeth dental problems	0.5	0.7	1.5	0.6	0.9	0.4	0.6	1.2	1.0
Fluid intelligence score	0.5	1.1	1.7	1.3	0.7	0.0	1.2	1.2	1.2
Gout (self-reported)	0.5	0.7	2.7	-1.6	-0.7	-0.3	-0.6	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	1.2	1.1	0.5	0.3	0.4	0.4
Mean time to correctly identify matches	0.5	0.9	1.7	-1.3	-1.1	-0.3	-0.8	-0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-0.7	0.2	0.7	-1.1	-0.7	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.8	0.7	0.1	-1.4	1.3	-0.1	0.3
Average weekly red wine intake	0.5	0.7	1.0	-1.0	-0.8	-1.0	-0.4	-1.0	-0.8
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.5	0.7	-0.5	1.0	0.9	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	0.5	-0.3	-1.3	1.2	0.4	0.4
Leg fat percentage (left)	0.5	1.6	2.9	1.6	1.1	1.3	0.5	1.7	1.1
Fractured/broken bones in last 5 years	0.5	0.6	2.0	0.4	1.0	1.4	-0.6	0.5	0.3
Pack years of smoking	0.5	0.7	1.6	-0.1	-0.1	1.1	-1.3	-0.7	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	-0.6	-0.4	-1.5	0.9	0.1	0.3
Reaction Time	0.4	0.7	1.3	-1.1	-0.8	0.5	-1.1	-0.5	-0.9
Age at First Birth	0.4	0.6	1.6	-1.3	-0.6	-0.6	-0.5	-0.8	-0.7
Fasting Glucose	0.4	0.4	1.6	0.3	0.4	-1.3	0.7	0.4	0.4
Neuroticism (2016)	0.4	0.6	1.5	0.6	1.1	0.2	0.3	1.2	0.8
Ulcerative Colitis	0.4	0.6	1.3	0.7	1.1	-0.1	0.6	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.1	-0.2	-0.5	-1.1	-0.2	-0.9	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	-0.2	0.0	-1.3	0.9	-0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.8	0.1	0.9	0.1	0.8	0.9	1.4
Had menopause	0.4	0.5	1.1	-0.1	-0.6	-0.6	-0.6	-1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-0.1	0.6	0.3	0.6	0.9	1.2
Father’s age at death	0.4	0.5	0.9	-0.1	0.7	-0.8	0.9	0.3	1.0
Prospective memory result	0.4	0.5	1.1	-1.1	-0.3	-0.8	-0.2	-0.9	-0.5
Birth weight	0.4	0.9	2.1	0.9	0.9	1.4	-0.5	1.0	0.7
Leg fat percentage (right)	0.4	1.5	2.7	1.6	0.9	0.8	1.0	1.6	1.2
Leg fat mass (right)	0.4	1.4	2.3	1.4	0.9	0.8	0.9	1.5	1.2
Mood swings	0.4	0.8	1.3	0.5	1.1	0.7	0.5	1.1	1.1
Diabetes diagnosed by doctor	0.4	0.6	2.5	-0.0	-0.6	-1.6	0.6	-0.5	-0.3
Medication: Gliclazide	0.4	0.5	1.2	-1.1	-0.7	-1.1	0.2	-0.1	0.1
Wears glasses or contact lenses	0.4	0.5	1.0	0.2	0.4	-0.6	0.9	1.0	0.7
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	0.7	0.3	-0.1	0.7	0.8	0.8
Diastolic blood pressure, automated reading	0.4	1.4	2.2	1.3	1.3	0.1	1.1	1.2	1.5
Ever depressed for a whole week	0.4	0.6	1.3	-0.7	-0.9	-1.1	0.3	-0.7	-0.3
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.8	-1.0	-0.6	-0.5	-0.5	-0.6
Leg fat mass (left)	0.4	1.5	2.5	1.5	1.1	1.2	0.7	1.6	1.2
Worry (Nagel 2018)	0.3	0.6	1.4	0.6	0.7	0.0	0.9	0.8	1.2
Major Depression (MDD)	0.3	0.3	1.4	0.3	0.0	1.2	-0.7	0.1	0.1
Triglycerides	0.3	0.4	1.6	-0.2	0.0	1.2	-1.0	-0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.9	0.1	-0.6	0.7	0.5	0.3
Waist Hip Ratio (WHR)	0.3	1.5	2.5	-1.4	-1.3	0.4	-1.6	-1.2	-1.2
Chronotype (morning person)	0.3	0.8	2.2	-0.2	0.3	1.3	-1.5	-0.0	-0.6
Sensitivity / hurt feelings	0.3	0.5	1.3	0.6	0.8	0.5	0.1	1.1	0.8
Hand grip strength (right)	0.3	0.8	2.2	1.4	0.6	1.5	0.0	0.4	0.5
Average weekly fortified wine intake	0.3	0.3	1.2	0.6	0.2	-0.5	1.1	0.0	0.4
Fed-up feelings	0.3	0.5	1.1	-0.4	-0.5	-0.4	-0.6	-1.0	-1.1
Sitting height	0.3	2.2	4.7	1.8	1.0	-1.7	2.2	0.3	1.1
Trunk fat mass	0.3	1.1	2.1	1.4	0.7	0.3	1.0	1.4	1.1
Financial difficulties in last 2 years	0.3	0.3	1.4	-0.6	-0.4	-1.2	0.4	-0.2	0.0
Diabetes (self-reported)	0.3	0.5	2.3	-0.1	-0.5	-1.5	0.7	-0.3	-0.1
Weight	0.3	1.2	2.1	1.5	0.7	-0.2	1.4	1.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.1	-1.0	-1.3	-0.2	-0.8	-1.4	-1.1
Asthma	0.3	0.7	1.1	0.5	1.1	-0.6	0.9	0.9	0.9
Depression (self-reported)	0.3	0.4	1.4	-0.4	0.6	1.2	-0.1	0.0	0.7
Tense / ‘highly strung’	0.3	0.5	1.3	-0.1	0.7	0.6	0.2	1.1	1.0
Medication: Amlodipine	0.3	0.4	0.8	0.0	0.9	0.5	0.4	0.7	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.0	1.2	0.6	-0.1	0.4	0.5
Qualifications: College or University degree	0.3	0.9	2.9	0.1	-0.1	-1.7	1.3	0.5	0.7
Neck or shoulder pain in last month	0.3	0.4	1.0	0.3	0.7	-0.2	0.7	1.0	0.7
Angina (self-reported)	0.3	0.4	1.8	-0.4	-0.4	-1.3	0.4	-0.4	-0.4
Suffer from ‘nerves’	0.3	0.5	1.0	-0.2	0.8	0.4	0.4	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-0.7	-0.7	-1.1	-0.1	-0.9	-0.6
Medication for cholesterol	0.3	0.4	0.7	-0.7	-0.6	0.1	-0.7	-0.8	-0.8
Ever taken oral contraceptive pill	0.3	0.4	1.5	-0.1	-0.7	-1.2	0.6	0.0	0.0
Hearing aid user	0.3	0.3	0.6	0.3	-0.8	-0.3	-0.6	-0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.9	1.0	-0.2	-0.6	1.4	0.6	0.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	0.3	0.3	0.1	0.3	0.9	0.7
Ovarian Cancer	0.2	0.2	0.6	0.3	0.1	0.7	-0.7	-0.3	-0.5
Mean Putamen Volume	0.2	0.2	0.4	-0.5	-0.5	0.7	-0.5	0.2	-0.1
Smoking Status	0.2	0.6	1.2	-0.5	-0.9	0.3	-1.0	-0.4	-1.1
Allergy or Eczema	0.2	0.5	0.9	-0.9	-0.4	-0.9	-0.4	-0.8	-0.6
Tanning	0.2	2.4	4.3	2.1	1.5	1.0	1.0	1.8	1.6
Hand grip strength (left)	0.2	0.5	1.6	1.2	0.3	0.7	0.5	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.4	0.2	-0.7	0.6	0.3	0.3
Trunk fat percentage	0.2	0.7	1.5	1.2	0.5	0.2	0.8	1.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.0	-0.3	-0.7	-0.3	-0.6	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.3	0.4	0.9	-0.6	0.1	0.3
Supplements: Glucosamine	0.2	0.3	1.0	0.2	0.1	1.0	-0.7	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.7	-0.1	0.6	-0.6	0.1	-0.1
Qualifications: None of the above	0.2	0.4	1.4	-0.3	-0.1	0.6	-1.2	-0.4	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.3	-0.1	-0.0	-0.7	-0.5	-0.7
Medication: Simvastatin	0.2	0.3	0.8	0.4	0.2	-0.6	0.9	0.6	0.5
Neuroticism score	0.2	0.5	1.0	0.5	1.0	0.5	0.3	0.7	0.9
Pulse rate	0.2	0.4	1.2	-0.4	-1.1	-0.6	-0.3	-0.7	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	-0.2	0.3	1.2	-0.8	0.3	-0.0
Arm fat mass (right)	0.2	0.8	1.3	1.2	0.5	0.4	0.9	1.2	0.9
Length of working week for main job	0.2	0.2	0.6	0.1	0.4	0.8	-0.7	-0.0	-0.2
Birth weight of first child	0.2	0.3	0.7	0.4	-0.4	-0.8	0.8	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.7	-0.8	-0.5	0.1	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.6	-0.0	-0.9	0.8	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	0.1	0.0	0.9	-0.6	-0.3	-0.0
Headache pain in last month	0.2	0.4	1.4	-0.1	-0.1	-1.2	0.9	-0.1	0.2
Glaucoma (self-reported)	0.2	0.2	0.7	0.0	-0.3	-0.2	0.4	0.8	0.6
Body fat percentage	0.2	0.9	1.8	1.3	0.5	0.5	0.8	1.4	0.9
Arm fat-free mass (right)	0.2	1.2	3.0	1.7	1.1	0.3	1.1	0.8	1.1
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.8	-0.3	-0.4	-0.2	-0.7	-0.3
Whole body fat mass	0.2	0.9	1.7	1.3	0.6	0.5	0.9	1.3	1.0
Arm predicted mass (right)	0.2	1.1	2.3	1.5	1.0	0.1	1.2	0.8	1.1
Comparative height size at age 10	0.2	1.0	2.5	1.1	0.1	-1.3	1.6	0.3	0.9
Age at last live birth	0.2	0.2	0.7	-0.4	-0.9	-0.2	0.4	0.1	0.5
Leg pain on walking	0.2	0.3	0.5	0.6	0.7	-0.1	0.4	0.4	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.5	0.4	-0.4	0.8	0.3	0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.8	0.0	-0.8	0.7	0.2	-0.1
Ever had bowel cancer screening	0.2	0.3	0.6	0.2	0.4	-0.8	0.5	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.8	0.5	0.1	0.5	0.2	0.4
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.9	-0.2	-0.5	0.3	-0.1	0.5
Mineral and other dietary supplements	0.2	0.2	0.5	-0.0	0.1	0.7	-0.6	-0.6	-0.3
Asthma (self-reported)	0.2	0.4	0.9	0.2	0.9	-0.4	0.6	0.8	0.6
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.8	-0.1	-0.1	-0.3	-0.8	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	1.1	0.2	-0.3	1.0	-0.5	0.2	-0.0
Arm fat mass (left)	0.2	0.7	1.2	1.1	0.3	0.2	0.9	1.0	0.8
Miserableness	0.2	0.4	0.9	-0.1	0.1	-0.5	0.9	0.4	1.0
Guilty feelings	0.2	0.4	0.9	0.2	0.8	0.3	0.4	0.4	0.9
Financial situation satisfaction	0.2	0.3	0.9	-0.5	-0.3	0.9	-0.4	0.4	0.3
Alcohol drinker status: Never	0.2	0.3	0.7	0.4	0.3	0.0	0.6	0.6	0.8
Arm fat-free mass (left)	0.2	0.8	2.0	1.4	0.8	0.0	1.1	0.6	0.9
Risk taking	0.2	0.3	1.0	0.4	-0.1	1.0	-0.7	0.3	-0.1
Age started oral contraceptive pill	0.2	0.2	0.8	0.0	-0.3	-0.9	0.2	-0.4	-0.6
Myopia	0.2	0.3	0.5	-0.3	0.3	-0.7	0.3	0.7	0.7
Bipolar Disorder (2018)	0.1	0.2	1.0	-0.1	0.4	1.0	-0.2	0.2	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.4	0.2	0.9	-0.8	0.1	-0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.6	-0.4	0.0	-0.6	-0.2
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.1	0.3	-0.1	0.5	0.2	0.6
Schizophrenia (2018)	0.1	0.2	0.7	-0.5	-0.0	0.4	-0.8	-0.1	-0.2
Prostate Cancer	0.1	0.1	0.4	0.6	-0.1	0.6	0.0	-0.2	0.0
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.2	0.0	-0.7	-0.0	-0.4	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.8	0.9	0.4	0.2	0.1	0.1	0.1
Schizophrenia (2014)	0.1	0.1	0.5	-0.4	0.3	0.4	-0.7	0.0	0.1
BMI	0.1	0.6	1.0	0.8	0.3	0.3	1.0	1.0	1.0
Respiratory disease	0.1	0.1	0.4	-0.4	0.7	0.2	-0.1	0.3	0.3
Lung FEV1/FVC ratio	0.1	0.8	2.2	0.7	-0.3	-1.5	1.3	0.0	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.3	0.3	0.6	-0.2	-0.1	0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	0.2	0.1	-0.0	-0.5	-0.2
Current tobacco smoking	0.1	0.1	0.3	-0.2	-0.6	0.3	-0.1	0.3	0.0
Age when periods started (menarche)	0.1	0.2	0.4	0.1	0.3	0.7	-0.2	0.6	0.4
Medication: Atenolol	0.1	0.1	0.3	0.3	0.5	0.1	0.1	-0.2	0.1
Body mass index (BMI)	0.1	0.5	0.9	1.0	0.3	0.2	0.9	0.9	0.8
Impedance of leg (left)	0.1	0.3	0.9	0.3	0.4	1.0	-0.8	0.5	-0.2
Number of incorrect matches in round	0.1	0.2	0.4	-0.3	-0.1	-0.1	-0.4	-0.5	-0.7
Alcohol usually taken with meals	0.1	0.1	0.3	-0.3	-0.1	-0.6	-0.0	-0.2	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.4	-0.3	-0.3
Impedance of arm (right)	0.1	0.3	0.6	-0.8	-0.4	-0.3	-0.6	-0.1	-0.6
Arm fat percentage (right)	0.1	0.3	0.8	0.6	-0.1	0.3	0.5	0.9	0.4
Trunk fat-free mass	0.1	0.7	1.4	1.1	0.6	-0.6	1.2	0.3	0.8
Hip circumference	0.1	0.5	1.2	1.0	-0.3	-0.8	1.1	0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.8	-0.5	0.2	-0.3	0.3	0.4
Number of live births	0.1	0.2	0.4	-0.4	0.1	0.6	-0.6	0.2	-0.2
Happiness	0.1	0.2	0.3	-0.3	-0.2	0.0	0.5	0.6	0.6
Lung cancer (father)	0.1	0.1	0.2	-0.2	-0.3	-0.1	-0.1	-0.5	-0.3
Impedance of arm (left)	0.1	0.6	1.0	-1.0	-0.8	-0.6	-0.7	-0.5	-0.9
Trunk predicted mass	0.1	0.7	1.3	1.1	0.6	-0.5	1.1	0.3	0.8
Standing height	0.1	0.8	1.2	1.1	0.7	-0.9	1.1	0.5	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	0.1	0.3	0.3	0.4	0.6
Peak expiratory flow (PEF)	0.1	0.2	0.6	0.8	-0.6	-0.2	0.6	-0.2	0.3
Loud music exposure frequency	0.1	0.1	0.1	0.2	0.1	-0.1	0.3	0.3	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.3	0.5	0.4	-0.5	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.3	0.2	0.5	-0.4	-0.2	0.0
Number of children fathered	0.1	0.1	0.2	0.2	0.3	-0.4	0.4	0.2	0.3
Medication: Allopurinol	0.1	0.1	0.3	-0.2	0.1	0.5	-0.1	0.6	0.3
Smoking status: Previous	0.1	0.2	0.7	-0.1	0.1	-0.8	0.1	-0.2	-0.4
Whole body fat-free mass	0.1	0.4	0.9	0.8	0.3	-0.5	1.0	0.1	0.6
Arm fat percentage (left)	0.1	0.3	0.8	0.7	0.0	0.3	0.6	0.9	0.5
Smoking status: Current	0.1	0.2	0.6	-0.4	-0.8	0.2	-0.3	0.0	-0.3
Whole body water mass	0.1	0.4	0.9	0.8	0.3	-0.4	0.9	0.1	0.6
Basal metabolic rate	0.1	0.5	1.1	1.0	0.4	-0.3	1.0	0.4	0.7
Irritability	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	0.1	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	0.1	-0.4	-0.7	0.2	-0.2	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.4	-0.1	-0.5
Arm predicted mass (left)	0.1	0.7	1.8	1.3	0.8	0.1	0.9	0.5	0.8
Height	0.0	0.5	1.9	1.4	0.8	0.5	-0.1	0.2	0.0
Neuroticism	0.0	0.0	0.1	-0.2	0.0	-0.3	0.1	-0.2	0.0
Hair Pigment	0.0	1.1	2.8	-1.1	-1.0	-1.7	0.3	-1.1	-0.6
Relative age of first facial hair	0.0	0.1	0.2	-0.2	-0.5	-0.2	-0.4	-0.1	-0.4
Impedance of leg (right)	0.0	0.0	0.1	0.3	0.1	0.0	-0.1	0.4	-0.0
Leg fat-free mass (left)	0.0	0.2	0.5	0.4	0.0	-0.5	0.7	-0.0	0.4
Relative age voice broke	0.0	0.1	0.2	-0.0	0.4	-0.1	0.2	0.2	0.4
Leg predicted mass (left)	0.0	0.2	0.6	0.4	0.1	-0.5	0.8	0.0	0.4
Waist circumference	0.0	0.2	0.6	0.1	-0.8	-0.3	0.1	-0.2	-0.4
Nervous feelings	0.0	0.1	0.2	-0.1	0.4	-0.0	-0.1	0.3	0.3
Had other major operations	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.1	-0.0	-0.1
Time employed in main current job	0.0	0.0	0.1	-0.1	-0.2	0.0	0.0	0.2	-0.1
Falls in the last year	0.0	0.0	0.1	0.2	0.1	-0.2	0.2	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	-0.1	-0.1	-0.5	0.2	-0.2	0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.2	-0.3	-0.0	0.1	-0.1	-0.4
Heart disease (mother)	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.2	-0.1	-0.1
Overall health rating	0.0	0.1	0.4	-0.7	0.1	-0.1	-0.1	0.2	0.2
Leg fat-free mass (right)	0.0	0.1	0.1	0.2	0.1	-0.1	0.4	-0.1	0.2
Loneliness, isolation	0.0	0.1	0.1	0.3	0.1	-0.0	0.4	-0.2	0.2
Eye problems/disorders: Cataract	0.0	0.1	0.2	0.4	0.2	-0.2	-0.0	0.2	-0.1
Leg predicted mass (right)	0.0	0.1	0.2	0.3	0.2	-0.1	0.5	0.0	0.3
Unable to work because of sickness or disability	0.0	0.1	0.2	-0.0	0.4	0.3	0.0	0.2	0.1
Impedance of whole body	0.0	0.1	0.3	-0.1	-0.1	0.2	-0.6	0.2	-0.4

Hub : Genes

C1orf38

Models

Trait associations