Best TWAS P=6.36e-09 · Best GWAS P=1.82e-07 conditioned to 0.034
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CPLX1 | 0.20 | 0.11 | lasso | 6 | 0.11 | 2.5e-09 | -5.1 | 5.1 | 2.8e-07 | -0.97 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-440L14.1 | 0.58 | 0.38 | enet | 36 | 0.48 | 1.9e-43 | -4.5 | 5.2 | 2.1e-07 | -0.69 | 0.11 | 0.86 | FALSE |
| 3 | GTEx | Brain Cerebellum | PCGF3 | 0.55 | 0.29 | enet | 10 | 0.35 | 2.6e-11 | -4.5 | 5.2 | 2.3e-07 | -0.51 | 0.09 | 0.88 | FALSE |
| 4 | GTEx | Muscle Skeletal | AC139887.4 | 0.12 | 0.10 | enet | 14 | 0.11 | 8.3e-11 | -4.7 | 5.5 | 3.5e-08 | -0.68 | 0.08 | 0.90 | FALSE |
| 5 | GTEx | Nerve Tibial | CPLX1 | 0.26 | 0.05 | lasso | 5 | 0.09 | 1.1e-06 | -5.2 | 5.3 | 1.3e-07 | -0.93 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Thyroid | CPLX1 | 0.17 | 0.07 | enet | 30 | 0.13 | 7.2e-10 | -5.2 | 5.2 | 1.8e-07 | -0.78 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCGF3 | 0.03 | 0.00 | blup | 69 | 0.01 | 3.7e-03 | 3.8 | 5.3 | 1.3e-07 | -0.60 | 0.02 | 0.36 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCGF3 | 0.08 | 0.02 | lasso | 4 | 0.07 | 1.9e-08 | -3.3 | 5.8 | 6.4e-09 | -0.61 | 0.03 | 0.87 | TRUE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCGF3 | 0.13 | 0.00 | blup | 69 | 0.04 | 1.4e-02 | -5.2 | 5.4 | 6.7e-08 | -0.86 | 0.01 | 0.74 | FALSE |