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chr3:194,678,015-196,927,181

Best TWAS P=3.2e-61 · Best GWAS P=5.78e-83 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Brain Frontal Cortex BA9	SDHAP1	0.26	0.08	lasso	3	0.05	2.4e-02	19.20	-16.5	3.2e-61	-0.91	0.01	0.81	TRUE
25	GTEx	Lung	MUC20	0.12	0.01	enet	28	0.04	3.3e-04	11.61	-7.2	4.6e-13	-0.40	0.14	0.06	TRUE
38	GTEx	Testis	MUC20	0.27	0.12	enet	21	0.10	3.3e-05	-6.03	-7.0	1.8e-12	-0.29	0.20	0.04	TRUE
7	GTEx	Brain Putamen basal ganglia	MUC20	0.46	0.27	lasso	8	0.21	8.6e-06	-6.03	-7.0	3.7e-12	-0.32	0.11	0.18	TRUE
30	GTEx	Pancreas	LINC00969	0.50	0.07	enet	31	0.22	1.2e-09	-6.03	-6.8	1.1e-11	-0.39	0.61	0.10	TRUE
12	GTEx	Breast Mammary Tissue (Male)	LINC00969	0.41	0.20	lasso	6	0.18	4.5e-05	-7.71	-5.8	5.0e-09	-0.30	0.06	0.06	TRUE
16	GTEx	Esophagus Mucosa	UBXN7	0.17	0.02	lasso	4	0.01	5.1e-02	4.12	5.6	1.9e-08	0.11	0.05	0.08	TRUE
52	YFS	Blood	MUC20	0.58	0.19	enet	74	0.51	4.5e-197	0.68	-5.5	5.1e-08	-0.20	1.00	0.00	TRUE
31	GTEx	Skin Not Sun Exposed Suprapubic	PCYT1A	0.15	0.06	lasso	7	0.08	3.9e-05	2.19	5.2	1.8e-07	0.16	0.76	0.03	TRUE
48	GTEx	Whole Blood	LINC00969	0.31	0.04	enet	31	0.17	3.5e-15	-6.03	-5.1	2.7e-07	-0.38	0.96	0.02	TRUE
14	GTEx	Breast Mammary Tissue (Female)	SDHAP1	0.34	0.04	lasso	7	0.16	1.8e-05	19.30	-13.6	6.5e-42	-0.78	0.01	0.86	FALSE
43	GTEx	Thyroid	AC024937.6	0.16	0.07	lasso	4	0.06	1.3e-05	11.61	-12.2	4.1e-34	-0.68	0.60	0.05	FALSE
18	GTEx	Esophagus Muscularis	MIR570	0.18	0.00	enet	13	0.02	2.2e-02	11.72	-12.1	7.2e-34	-0.51	0.10	0.12	FALSE
45	GTEx	Thyroid	RP11-480A16.1	0.16	0.08	lasso	3	0.06	2.0e-05	11.61	-11.8	6.1e-32	-0.70	0.76	0.12	FALSE
11	GTEx	Breast Mammary Tissue (Male)	SDHAP1	0.10	0.00	lasso	1	-0.01	8.3e-01	11.53	-11.5	9.1e-31	-0.65	0.03	0.15	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	RP11-480A16.1	0.08	0.02	enet	6	0.01	7.1e-02	12.34	11.3	1.3e-29	0.58	0.06	0.33	FALSE
8	GTEx	Breast Mammary Tissue	SDHAP1	0.21	0.02	enet	21	0.11	3.4e-06	1.24	-11.2	4.6e-29	-0.56	0.07	0.86	FALSE
24	GTEx	Liver	LINC00969	0.42	0.19	lasso	6	0.13	2.2e-04	11.61	-10.6	4.1e-26	-0.68	0.25	0.32	FALSE
20	GTEx	Heart Left Ventricle	MUC20	0.26	0.11	enet	59	0.14	1.1e-07	-6.03	-10.0	1.1e-23	-0.37	0.29	0.16	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	MIR570	0.21	0.15	enet	13	0.20	3.2e-11	11.67	-9.7	3.5e-22	-0.62	0.96	0.01	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDHAP1	0.08	0.03	enet	11	0.05	3.1e-06	11.67	-9.0	1.6e-19	-0.55	0.23	0.29	FALSE
3	GTEx	Artery Tibial	MIR570	0.08	0.02	lasso	7	0.01	2.2e-02	11.61	-8.9	4.6e-19	-0.64	0.15	0.20	FALSE
23	GTEx	Liver	MUC20	0.34	0.17	lasso	4	0.19	5.3e-06	-3.01	-8.7	3.9e-18	-0.53	0.16	0.20	FALSE
27	GTEx	Nerve Tibial	MIR570	0.10	0.00	lasso	11	0.00	1.9e-01	0.31	-8.6	8.9e-18	-0.56	0.07	0.66	FALSE
42	GTEx	Thyroid	MIR570	0.20	0.09	lasso	6	0.12	2.3e-09	11.61	-8.5	1.5e-17	-0.59	0.97	0.00	FALSE
17	GTEx	Esophagus Mucosa	MIR570	0.20	0.10	lasso	8	0.07	2.3e-05	-6.03	-8.4	6.3e-17	-0.47	0.78	0.03	FALSE
49	METSIM	Adipose	LINC00969	0.35	0.12	enet	59	0.24	4.6e-36	-7.71	-8.2	3.0e-16	-0.42	1.00	0.00	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	RP11-141C7.3	0.35	0.15	enet	20	0.21	6.7e-12	-3.60	8.1	5.2e-16	0.32	1.00	0.00	FALSE
41	GTEx	Thyroid	MUC20	0.65	0.22	lasso	9	0.28	1.8e-21	-6.03	-8.1	5.5e-16	-0.49	1.00	0.00	FALSE
40	GTEx	Testis	LINC00969	0.58	0.14	lasso	15	0.33	2.3e-15	-7.71	-7.9	2.6e-15	-0.51	0.98	0.01	FALSE
29	GTEx	Pancreas	MIR570	0.30	0.02	lasso	7	0.05	5.0e-03	-6.03	-7.9	3.6e-15	-0.33	0.08	0.08	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RP11-141C7.3	0.04	0.01	enet	7	0.01	1.9e-01	-3.60	7.9	3.7e-15	0.41	0.03	0.12	FALSE
47	GTEx	Vagina	LINC00969	0.57	0.00	enet	26	0.18	7.5e-05	-0.77	-7.4	1.1e-13	-0.37	0.03	0.24	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MUC20	0.50	0.20	lasso	14	0.37	1.8e-47	-6.03	-7.2	8.7e-13	-0.41	1.00	0.00	FALSE
37	GTEx	Stomach	LINC00969	0.59	0.04	enet	43	0.21	1.7e-10	-1.41	-7.1	1.1e-12	-0.45	0.61	0.21	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	TNK2	0.05	0.03	lasso	2	0.02	9.4e-04	-6.03	7.1	1.6e-12	0.35	0.04	0.16	FALSE
4	GTEx	Brain Cerebellum	LINC00969	0.64	0.17	lasso	12	0.28	6.6e-09	-6.03	-7.0	2.0e-12	-0.38	0.40	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TCTEX1D2	0.12	0.02	blup	384	0.05	6.1e-07	1.40	6.9	5.0e-12	0.32	0.96	0.01	FALSE
10	GTEx	Breast Mammary Tissue (Male)	UBXN7	0.22	-0.01	lasso	4	0.01	1.6e-01	-0.98	-6.7	1.6e-11	-0.31	0.05	0.13	FALSE
9	GTEx	Breast Mammary Tissue	LINC00969	0.59	0.11	lasso	11	0.34	2.8e-18	-7.71	-6.7	2.5e-11	-0.43	0.94	0.01	FALSE
46	GTEx	Uterus	TNK2	0.39	0.01	enet	22	0.02	1.3e-01	-1.79	6.6	4.5e-11	0.50	0.02	0.45	FALSE
44	GTEx	Thyroid	LINC00969	0.67	0.09	enet	31	0.43	2.3e-35	-6.03	-6.3	2.5e-10	-0.44	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SDHAP1	0.07	0.00	blup	24	0.05	4.0e-06	-3.94	-6.2	4.2e-10	-0.41	0.06	0.18	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	SDHAP1	0.28	0.10	enet	17	0.18	2.7e-10	2.19	-6.2	4.8e-10	-0.44	0.63	0.20	FALSE
21	GTEx	Heart Left Ventricle	MIR570	0.27	0.05	enet	22	0.09	2.7e-05	-6.03	-6.1	1.2e-09	-0.46	0.53	0.25	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	LINC00969	0.57	0.16	lasso	9	0.18	1.2e-05	-3.01	-6.0	1.6e-09	-0.38	0.18	0.16	FALSE
15	GTEx	Colon Transverse	LINC00969	0.58	0.08	lasso	13	0.25	2.2e-12	4.32	-5.9	2.9e-09	-0.37	0.85	0.03	FALSE
26	GTEx	Nerve Tibial	SDHAP1	0.43	0.07	lasso	15	0.19	3.6e-13	1.24	-5.7	1.1e-08	-0.39	0.24	0.75	FALSE
53	YFS	Blood	TNK2	0.01	0.00	bslmm	282	0.01	2.9e-03	4.04	5.7	1.1e-08	0.41	0.06	0.13	FALSE
39	GTEx	Testis	MIR570	0.17	0.03	enet	26	0.07	5.9e-04	6.01	-5.7	1.2e-08	-0.51	0.13	0.32	FALSE
19	GTEx	Heart Atrial Appendage	LINC00969	0.30	0.13	enet	18	0.10	3.5e-05	-6.03	-5.7	1.4e-08	-0.28	0.30	0.05	FALSE
57	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SDHAP1	0.14	0.01	blup	24	0.10	2.2e-07	-5.32	-5.7	1.4e-08	-0.40	0.26	0.06	FALSE
36	GTEx	Skin Sun Exposed Lower leg	LINC00969	0.59	0.17	enet	55	0.44	7.5e-40	2.19	-5.7	1.5e-08	-0.33	1.00	0.00	FALSE
50	NTR	Blood	RNF168	0.02	0.00	bslmm	410	0.00	9.7e-03	0.88	5.5	2.9e-08	0.33	0.05	0.13	FALSE
22	GTEx	Heart Left Ventricle	LINC00969	0.25	0.00	enet	25	0.06	4.2e-04	-6.03	-5.5	4.2e-08	-0.40	0.07	0.12	FALSE
28	GTEx	Pancreas	SDHAP1	0.27	0.02	lasso	6	0.09	1.7e-04	1.24	-5.4	7.1e-08	-0.28	0.18	0.15	FALSE
51	NTR	Blood	TFRC	0.03	0.01	enet	18	0.01	1.7e-05	18.61	5.2	2.0e-07	0.59	0.02	0.94	FALSE