Best TWAS P=1.78e-20 · Best GWAS P=1.36e-22 conditioned to 0.514
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C1QTNF7 | 0.14 | 0.11 | lasso | 3 | 0.18 | 2.1e-21 | 5.5 | -8.4 | 4.7e-17 | 0.82 | 0.10 | 0.90 | FALSE |
2 | GTEx | Esophagus Mucosa | FBXL5 | 0.13 | 0.05 | lasso | 4 | 0.05 | 3.2e-04 | -9.8 | 9.0 | 1.6e-19 | -0.94 | 0.01 | 0.99 | FALSE |
3 | GTEx | Heart Atrial Appendage | FBXL5 | 0.19 | 0.00 | enet | 27 | 0.01 | 1.7e-01 | 5.3 | 5.8 | 8.9e-09 | -0.56 | 0.04 | 0.79 | FALSE |
4 | GTEx | Muscle Skeletal | FAM200B | 0.08 | 0.03 | lasso | 3 | 0.02 | 6.5e-03 | 4.7 | 6.3 | 2.3e-10 | -0.54 | 0.25 | 0.52 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | FBXL5 | 0.15 | 0.00 | lasso | 2 | 0.00 | 2.4e-01 | 7.9 | 8.1 | 7.6e-16 | -0.47 | 0.14 | 0.05 | FALSE |
6 | GTEx | Thyroid | FBXL5 | 0.14 | 0.08 | lasso | 4 | 0.08 | 6.8e-07 | -9.7 | 8.5 | 2.1e-17 | -0.93 | 0.01 | 0.99 | FALSE |
7 | NTR | Blood | C1QTNF7 | 0.13 | 0.14 | enet | 23 | 0.16 | 2.5e-50 | -9.7 | -9.3 | 1.8e-20 | 0.92 | 0.01 | 0.99 | TRUE |
8 | ROSMAP | Brain Pre-frontal Cortex | FBXL5 | 0.08 | 0.03 | blup | 568 | 0.04 | 1.7e-05 | 4.3 | 5.3 | 1.3e-07 | -0.48 | 0.78 | 0.19 | FALSE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | BST1 | 0.09 | 0.02 | enet | 9 | 0.05 | 7.8e-05 | 5.6 | -5.5 | 4.3e-08 | 0.25 | 0.22 | 0.05 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BST1 | 0.09 | 0.02 | blup | 85 | 0.05 | 8.3e-06 | 4.2 | -5.5 | 4.4e-08 | 0.27 | 0.65 | 0.04 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FAM200B | 0.30 | 0.10 | enet | 8 | 0.14 | 1.3e-05 | -1.3 | 7.3 | 3.4e-13 | -0.31 | 0.05 | 0.14 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | CC2D2A | 0.04 | 0.00 | blup | 109 | 0.00 | 9.9e-02 | 4.7 | -6.3 | 2.5e-10 | 0.73 | 0.05 | 0.24 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM200B | 0.08 | 0.03 | lasso | 3 | 0.02 | 2.8e-03 | 5.6 | 5.8 | 6.1e-09 | -0.17 | 0.07 | 0.03 | TRUE |