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chr4:54,503,768-57,110,821

Best TWAS P=3.61e-20 · Best GWAS P=0 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	ROSMAP	Brain Pre-frontal Cortex	RP11-231C18.1	0.20	0.04	lasso	3	0.14	1.7e-17	-5.7	-9.2	3.6e-20	0.11	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRD5A3	0.18	0.08	blup	44	0.09	1.0e-07	6.2	6.5	7.9e-11	0.04	0.00	1.00	TRUE
8	GTEx	Cells Transformed fibroblasts	KDR	0.53	0.20	enet	34	0.27	4.2e-20	5.2	5.2	2.0e-07	-0.06	1.00	0.00	TRUE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM165	0.02	0.04	lasso	3	0.03	1.0e-07	6.2	-6.2	5.1e-10	-0.03	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRD5A3	0.03	0.03	enet	4	0.05	3.1e-06	-4.9	6.2	5.7e-10	0.00	0.02	0.96	FALSE
2	GTEx	Adipose Subcutaneous	TMEM165	0.09	0.01	lasso	3	0.03	1.6e-03	6.2	-6.2	6.8e-10	-0.03	0.02	0.97	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM165	0.19	0.16	lasso	4	0.17	2.1e-18	6.2	-6.1	8.3e-10	-0.05	0.01	0.99	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	CLOCK	0.08	0.08	lasso	5	0.05	1.4e-03	6.1	6.1	9.1e-10	0.04	0.03	0.94	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM165	0.06	0.07	enet	11	0.06	2.1e-04	6.2	-6.1	9.1e-10	-0.06	0.01	0.96	FALSE
18	METSIM	Adipose	TMEM165	0.07	0.07	enet	12	0.07	1.1e-10	6.2	-6.1	1.0e-09	-0.04	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM165	0.05	0.06	enet	5	0.05	4.3e-06	6.1	-6.0	1.7e-09	-0.06	0.01	0.99	FALSE
16	GTEx	Spleen	TMEM165	0.17	0.13	enet	10	0.11	7.7e-04	5.5	-6.0	2.1e-09	-0.04	0.04	0.74	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM165	0.12	0.08	enet	12	0.08	2.1e-08	6.2	-5.9	3.2e-09	-0.05	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue	TMEM165	0.10	0.12	lasso	5	0.12	6.4e-07	5.5	-5.9	3.4e-09	-0.04	0.03	0.96	FALSE
7	GTEx	Breast Mammary Tissue (Female)	TMEM165	0.09	0.07	lasso	2	0.05	1.3e-02	6.1	-5.9	3.7e-09	-0.08	0.04	0.70	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLOCK	0.08	0.07	enet	9	0.06	4.5e-05	6.1	5.9	4.7e-09	0.07	0.02	0.96	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	SRD5A3	0.04	0.03	lasso	4	0.02	1.0e-03	5.7	5.8	6.0e-09	0.05	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRD5A3	0.26	0.12	lasso	6	0.10	7.0e-05	5.7	5.8	7.2e-09	0.05	0.01	0.96	FALSE
3	GTEx	Artery Aorta	CLOCK	0.13	0.05	enet	32	0.08	3.2e-05	6.1	5.8	7.6e-09	0.03	0.03	0.96	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM165	0.03	0.01	blup	55	0.02	1.4e-03	6.1	-5.8	9.2e-09	-0.07	0.02	0.92	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM165	0.08	0.06	lasso	3	0.09	1.5e-10	6.1	-5.7	1.1e-08	-0.07	0.01	0.99	FALSE
9	GTEx	Colon Sigmoid	SRD5A3-AS1	0.16	0.14	enet	18	0.13	2.9e-05	6.2	5.7	1.4e-08	0.03	0.03	0.93	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRD5A3	0.04	0.03	blup	44	0.03	1.1e-04	6.2	5.6	2.0e-08	0.06	0.00	0.99	FALSE
19	NTR	Blood	CLOCK	0.02	0.01	lasso	2	0.01	5.4e-05	5.5	5.6	2.3e-08	0.03	0.03	0.96	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRD5A3	0.21	0.14	lasso	4	0.14	2.6e-15	5.7	5.5	3.4e-08	0.06	0.02	0.98	FALSE
6	GTEx	Breast Mammary Tissue (Male)	TMEM165	0.18	0.11	lasso	10	0.11	1.4e-03	5.5	-5.5	4.0e-08	-0.03	0.03	0.81	FALSE
4	GTEx	Brain Cortex	TMEM165	0.31	0.08	lasso	6	0.04	2.2e-02	5.5	-5.5	4.5e-08	-0.03	0.04	0.72	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM165	0.22	0.20	enet	47	0.26	1.7e-31	6.1	-5.4	5.3e-08	-0.02	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRD5A3	0.12	0.07	lasso	2	0.06	4.2e-05	5.7	5.3	1.2e-07	0.07	0.01	0.93	FALSE
15	GTEx	Small Intestine Terminal Ileum	SRD5A3-AS1	0.40	0.32	lasso	3	0.28	4.5e-07	5.5	5.3	1.4e-07	0.03	0.06	0.81	FALSE
23	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRD5A3	0.09	0.08	lasso	4	0.09	2.7e-05	5.7	5.2	1.9e-07	0.08	0.02	0.74	FALSE
10	GTEx	Esophagus Mucosa	CLOCK	0.12	0.11	enet	22	0.09	9.3e-07	5.7	5.2	2.2e-07	0.05	0.06	0.94	FALSE
11	GTEx	Esophagus Muscularis	SRD5A3-AS1	0.15	0.04	enet	28	0.12	1.8e-07	4.4	5.2	2.4e-07	0.07	0.07	0.85	FALSE
17	GTEx	Thyroid	CLOCK	0.16	0.14	enet	46	0.14	9.5e-11	6.1	5.2	2.4e-07	0.09	0.02	0.98	FALSE
12	GTEx	Muscle Skeletal	SRD5A3-AS1	0.20	0.13	enet	25	0.20	1.4e-19	5.7	5.1	2.8e-07	0.03	0.11	0.88	FALSE
13	GTEx	Nerve Tibial	TMEM165	0.18	0.22	enet	29	0.27	1.6e-19	6.1	-5.1	2.9e-07	-0.04	0.02	0.98	FALSE