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chr4:37,915,462-40,274,255

Best TWAS P=7.81e-20 · Best GWAS P=2.68e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Artery Aorta	RP11-617D20.1	0.27	0.18	lasso	6	0.24	1.6e-13	8.2	9.1	7.8e-20	0.90	0.01	0.99	TRUE
47	GTEx	Muscle Skeletal	AC021860.1	0.16	0.10	lasso	7	0.13	1.1e-12	7.4	8.3	1.4e-16	0.76	0.02	0.98	TRUE
30	GTEx	Colon Sigmoid	AC021860.1	0.43	0.23	lasso	11	0.27	5.5e-10	8.1	7.7	1.1e-14	0.91	0.01	0.99	TRUE
46	GTEx	Muscle Skeletal	RFC1	0.10	0.10	lasso	5	0.07	4.2e-07	7.7	7.6	2.2e-14	-0.02	0.02	0.98	TRUE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ13197	0.08	0.04	enet	11	0.06	1.7e-07	8.2	7.3	3.9e-13	0.79	0.01	0.99	TRUE
109	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	6.3	-6.6	5.2e-11	-0.11	0.01	0.85	TRUE
16	GTEx	Brain Cerebellar Hemisphere	RFC1	0.18	0.10	lasso	4	0.11	1.0e-03	5.6	6.1	1.0e-09	-0.06	0.08	0.50	TRUE
106	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM156	0.07	0.01	blup	96	0.03	3.5e-04	4.3	-5.6	1.6e-08	-0.09	0.06	0.04	TRUE
26	GTEx	Breast Mammary Tissue	FAM114A1	0.11	0.04	lasso	3	0.05	1.0e-03	3.2	5.5	5.0e-08	0.15	0.34	0.04	TRUE
59	GTEx	Skin Sun Exposed Lower leg	RP11-617D20.1	0.20	0.10	lasso	4	0.11	3.2e-09	8.2	9.0	1.7e-19	0.95	0.01	0.99	FALSE
45	GTEx	Lung	RP11-617D20.1	0.19	0.14	enet	9	0.14	1.3e-10	8.2	9.0	2.2e-19	0.96	0.01	0.99	FALSE
15	GTEx	Artery Tibial	RP11-617D20.1	0.32	0.23	enet	39	0.28	5.0e-22	8.2	9.0	2.8e-19	0.86	0.01	0.99	FALSE
97	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ13197	0.06	0.00	blup	81	0.01	3.4e-02	8.1	9.0	2.8e-19	0.80	0.01	0.77	FALSE
69	GTEx	Testis	RP11-617D20.1	0.28	0.16	lasso	5	0.18	1.9e-08	8.1	8.9	4.9e-19	0.91	0.01	0.99	FALSE
53	GTEx	Pancreas	RP11-617D20.1	0.34	0.27	lasso	6	0.33	1.8e-14	7.4	8.9	5.8e-19	0.84	0.02	0.98	FALSE
41	GTEx	Heart Left Ventricle	AC021860.1	0.26	0.15	lasso	5	0.19	1.4e-10	7.4	8.8	9.5e-19	0.82	0.02	0.98	FALSE
40	GTEx	Heart Atrial Appendage	RP11-617D20.1	0.29	0.14	lasso	6	0.17	3.7e-08	8.1	8.8	1.0e-18	0.89	0.01	0.99	FALSE
42	GTEx	Heart Left Ventricle	RP11-617D20.1	0.28	0.14	lasso	5	0.14	6.8e-08	8.1	8.8	1.1e-18	0.94	0.01	0.99	FALSE
73	GTEx	Vagina	RP11-617D20.1	0.31	0.01	lasso	8	0.02	1.4e-01	8.1	8.8	1.7e-18	0.84	0.03	0.64	FALSE
32	GTEx	Colon Transverse	AC021860.1	0.32	0.10	lasso	10	0.07	2.4e-04	8.1	8.8	2.1e-18	0.95	0.01	0.99	FALSE
38	GTEx	Esophagus Muscularis	RP11-617D20.1	0.35	0.26	lasso	6	0.31	2.5e-19	8.1	8.7	2.4e-18	0.90	0.01	0.99	FALSE
103	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ13197	0.08	0.02	enet	9	0.04	1.7e-03	6.7	8.7	2.6e-18	0.72	0.02	0.66	FALSE
19	GTEx	Brain Cerebellum	RP11-617D20.1	0.59	0.23	lasso	8	0.39	1.0e-12	7.4	8.7	4.9e-18	0.77	0.01	0.99	FALSE
6	GTEx	Adipose Subcutaneous	RP11-617D20.1	0.28	0.26	lasso	6	0.28	2.4e-23	8.1	8.7	5.4e-18	0.94	0.01	0.99	FALSE
31	GTEx	Colon Sigmoid	RP11-617D20.1	0.45	0.34	lasso	8	0.34	9.5e-13	8.1	8.5	1.8e-17	0.96	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	AC021860.1	0.32	0.28	enet	20	0.36	2.7e-30	8.2	8.5	2.0e-17	0.88	0.01	0.99	FALSE
43	GTEx	Liver	RP11-617D20.1	0.24	0.12	lasso	3	0.10	1.3e-03	8.2	8.5	2.3e-17	0.99	0.01	0.97	FALSE
65	GTEx	Stomach	RP11-617D20.1	0.32	0.23	enet	13	0.20	6.5e-10	8.1	8.4	3.6e-17	0.96	0.01	0.99	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	AC021860.1	0.43	0.32	lasso	8	0.35	4.0e-20	8.2	8.4	3.8e-17	0.94	0.00	1.00	FALSE
44	GTEx	Lung	AC021860.1	0.19	0.07	enet	14	0.14	8.2e-11	7.4	8.4	4.1e-17	0.77	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ13197	0.04	0.02	blup	80	0.03	3.2e-07	8.1	8.3	8.2e-17	0.82	0.01	0.99	FALSE
74	GTEx	Whole Blood	AC021860.1	0.14	0.07	lasso	7	0.10	2.5e-09	8.2	8.3	9.4e-17	0.88	0.01	0.99	FALSE
76	METSIM	Adipose	AC021860.1	0.18	0.07	bslmm	596	0.12	4.0e-17	8.1	8.3	1.1e-16	0.80	0.01	0.99	FALSE
58	GTEx	Skin Sun Exposed Lower leg	AC021860.1	0.31	0.22	lasso	5	0.24	5.2e-20	8.1	8.3	1.2e-16	0.97	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ13197	0.06	0.05	lasso	6	0.04	8.5e-06	8.1	8.3	1.5e-16	0.97	0.01	0.99	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	RP11-617D20.1	0.23	0.13	lasso	3	0.13	1.7e-07	8.2	8.2	1.8e-16	0.99	0.01	0.99	FALSE
94	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FLJ13197	0.11	0.08	lasso	6	0.09	7.3e-05	8.2	8.2	2.1e-16	0.95	0.01	0.99	FALSE
68	GTEx	Testis	AC021860.1	0.23	0.16	lasso	5	0.23	1.3e-10	8.1	8.2	2.8e-16	0.83	0.01	0.99	FALSE
18	GTEx	Brain Cerebellum	AC021860.1	0.63	0.33	lasso	16	0.43	5.7e-14	7.4	8.2	3.4e-16	0.62	0.04	0.95	FALSE
71	GTEx	Thyroid	RP11-617D20.1	0.31	0.22	enet	20	0.29	3.5e-22	8.1	8.2	3.7e-16	0.80	0.01	0.99	FALSE
27	GTEx	Breast Mammary Tissue	RP11-617D20.1	0.35	0.20	lasso	5	0.19	4.9e-10	8.2	8.1	4.4e-16	0.98	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ13197	0.06	0.04	enet	9	0.06	1.3e-07	7.4	8.1	5.5e-16	0.73	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ13197	0.11	0.07	blup	85	0.10	3.4e-11	8.2	8.1	5.7e-16	0.77	0.01	0.99	FALSE
61	GTEx	Small Intestine Terminal Ileum	AC021860.1	0.38	0.17	lasso	7	0.15	3.3e-04	8.2	8.1	6.4e-16	0.92	0.01	0.94	FALSE
8	GTEx	Adipose Visceral Omentum	RP11-617D20.1	0.31	0.10	enet	21	0.17	3.9e-09	8.1	8.0	9.6e-16	0.79	0.01	0.99	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	AC021860.1	0.23	0.11	enet	14	0.11	8.9e-05	8.2	8.0	1.2e-15	0.90	0.01	0.99	FALSE
37	GTEx	Esophagus Muscularis	AC021860.1	0.40	0.19	enet	24	0.36	3.9e-23	8.2	7.8	5.4e-15	0.77	0.01	0.99	FALSE
7	GTEx	Adipose Visceral Omentum	AC021860.1	0.33	0.08	lasso	9	0.13	3.2e-07	8.2	7.8	6.6e-15	0.78	0.01	0.99	FALSE
35	GTEx	Esophagus Mucosa	AC021860.1	0.30	0.21	lasso	7	0.31	4.9e-21	8.1	7.8	8.3e-15	0.85	0.01	0.99	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	RP11-617D20.1	0.14	0.08	enet	18	0.13	6.8e-16	8.1	7.8	8.3e-15	0.78	0.02	0.98	FALSE
72	GTEx	Vagina	AC021860.1	0.42	0.04	lasso	12	0.07	1.2e-02	8.1	7.8	8.6e-15	0.87	0.02	0.82	FALSE
12	GTEx	Artery Aorta	AC021860.1	0.34	0.14	lasso	4	0.32	6.5e-18	7.4	7.7	1.3e-14	0.73	0.02	0.98	FALSE
52	GTEx	Pancreas	AC021860.1	0.41	0.33	lasso	6	0.44	5.0e-20	7.4	7.6	2.9e-14	0.64	0.17	0.83	FALSE
29	GTEx	Breast Mammary Tissue (Female)	RP11-617D20.1	0.16	0.12	enet	5	0.10	5.5e-04	7.0	7.6	3.2e-14	0.86	0.02	0.92	FALSE
39	GTEx	Heart Atrial Appendage	AC021860.1	0.48	0.07	lasso	15	0.19	8.1e-09	8.1	7.5	5.3e-14	0.78	0.02	0.98	FALSE
108	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	FLJ13197	0.20	0.01	blup	85	0.09	1.4e-03	8.2	7.5	8.1e-14	0.74	0.01	0.83	FALSE
10	GTEx	Adrenal Gland	AC021860.1	0.30	0.11	lasso	5	0.12	4.1e-05	8.1	7.4	1.3e-13	0.83	0.02	0.95	FALSE
87	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ13197	0.16	0.04	lasso	2	0.02	8.9e-02	7.4	7.4	1.6e-13	0.51	0.01	0.39	FALSE
14	GTEx	Artery Tibial	AC021860.1	0.30	0.09	enet	30	0.22	1.5e-17	8.2	7.3	2.8e-13	0.71	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ13197	0.20	0.10	blup	81	0.14	4.2e-14	8.1	7.3	2.8e-13	0.84	0.01	0.99	FALSE
66	GTEx	Stomach	UGDH-AS1	0.08	0.01	lasso	7	0.02	3.8e-02	-6.7	7.2	6.2e-13	-0.03	0.12	0.39	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ13197	0.12	0.00	blup	85	0.05	9.1e-04	8.2	7.2	6.3e-13	0.76	0.01	0.90	FALSE
75	GTEx	Whole Blood	RP11-617D20.1	0.14	0.06	lasso	3	0.05	4.2e-05	-5.5	7.2	6.8e-13	0.62	0.05	0.94	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	WDR19	0.02	0.02	enet	9	0.02	2.8e-03	7.1	7.2	8.1e-13	-0.04	0.37	0.08	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ13197	0.16	0.08	blup	82	0.13	7.1e-13	7.4	7.1	9.7e-13	0.60	0.10	0.90	FALSE
25	GTEx	Breast Mammary Tissue	AC021860.1	0.49	0.13	enet	29	0.27	2.2e-14	8.2	7.1	9.8e-13	0.77	0.01	0.99	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR19	0.04	0.01	blup	61	0.02	2.4e-03	7.0	7.1	1.6e-12	-0.03	0.02	0.96	FALSE
54	GTEx	Prostate	AC021860.1	0.28	0.15	enet	29	0.28	8.1e-08	7.4	7.0	2.1e-12	0.53	0.02	0.93	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ13197	0.11	0.07	blup	85	0.08	7.0e-10	8.2	7.0	2.1e-12	0.78	0.01	0.99	FALSE
84	YFS	Blood	WDR19	0.06	0.08	blup	478	0.10	1.0e-29	-4.9	7.0	2.3e-12	0.09	1.00	0.00	FALSE
64	GTEx	Stomach	AC021860.1	0.37	0.14	enet	27	0.18	5.9e-09	8.1	6.8	8.0e-12	0.79	0.01	0.99	FALSE
50	GTEx	Nerve Tibial	AC021860.1	0.43	0.20	lasso	13	0.30	8.5e-22	-2.6	6.8	1.1e-11	0.61	0.57	0.43	FALSE
17	GTEx	Brain Cerebellar Hemisphere	AC021860.1	0.50	0.30	lasso	6	0.34	1.7e-09	7.4	6.8	1.2e-11	0.60	0.09	0.80	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR19	0.03	0.04	blup	61	0.02	3.6e-03	-6.9	6.8	1.3e-11	-0.03	0.03	0.96	FALSE
67	GTEx	Testis	WDR19	0.28	0.29	lasso	5	0.27	1.6e-12	-6.7	6.8	1.4e-11	-0.03	0.89	0.11	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ13197	0.13	0.07	blup	81	0.08	2.7e-04	7.4	6.8	1.5e-11	0.66	0.02	0.81	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ13197	0.08	0.05	blup	85	0.03	6.4e-03	8.1	6.7	1.6e-11	0.83	0.01	0.98	FALSE
51	GTEx	Nerve Tibial	RP11-617D20.1	0.35	0.10	enet	81	0.20	7.0e-14	8.1	6.7	1.7e-11	0.57	0.01	0.99	FALSE
23	GTEx	Brain Putamen basal ganglia	RP11-617D20.1	0.44	0.12	lasso	7	0.26	8.3e-07	7.4	6.7	2.0e-11	0.61	0.02	0.93	FALSE
104	The Cancer Genome Atlas	Testicular Germ Cell Tumors	WDR19	0.09	0.01	blup	61	0.03	4.1e-02	-6.7	6.5	1.1e-10	-0.03	0.02	0.44	FALSE
60	GTEx	Skin Sun Exposed Lower leg	RP11-360F5.3	0.10	0.08	enet	25	0.07	9.0e-07	-4.9	6.4	1.2e-10	-0.04	0.98	0.01	FALSE
11	GTEx	Adrenal Gland	RP11-360F5.3	0.09	0.01	enet	12	0.02	6.2e-02	7.1	6.4	1.3e-10	-0.03	0.30	0.06	FALSE
99	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	WDR19	0.08	0.00	blup	61	0.03	1.9e-02	-6.8	6.4	1.3e-10	-0.03	0.03	0.57	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	TLR10	0.08	0.01	blup	517	0.03	3.4e-05	2.0	-6.4	1.4e-10	-0.16	0.78	0.03	FALSE
70	GTEx	Thyroid	AC021860.1	0.30	0.22	lasso	4	0.30	5.4e-23	-2.5	6.4	1.6e-10	0.63	0.97	0.03	FALSE
3	GTEx	Adipose Subcutaneous	WDR19	0.05	0.01	lasso	5	0.00	1.3e-01	-6.7	6.3	2.9e-10	-0.03	0.37	0.27	FALSE
49	GTEx	Nerve Tibial	KLHL5	0.13	0.07	enet	16	0.04	4.5e-04	-4.9	-6.3	3.0e-10	0.01	0.97	0.01	FALSE
28	GTEx	Breast Mammary Tissue (Female)	AC021860.1	0.25	0.06	lasso	6	0.16	1.6e-05	7.0	6.3	3.6e-10	0.62	0.06	0.54	FALSE
20	GTEx	Brain Frontal Cortex BA9	RP11-617D20.1	0.34	0.14	lasso	4	0.14	1.7e-04	7.4	6.2	4.3e-10	0.45	0.10	0.56	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	FAM114A1	0.23	0.17	enet	14	0.13	1.0e-07	4.8	6.2	4.6e-10	0.21	1.00	0.00	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	RP11-617D20.1	0.65	0.14	lasso	14	0.27	7.6e-08	7.4	6.2	6.3e-10	0.48	0.09	0.75	FALSE
62	GTEx	Small Intestine Terminal Ileum	UGDH-AS1	0.22	0.09	enet	11	0.17	1.3e-04	-5.3	6.1	8.1e-10	-0.05	0.09	0.26	FALSE
63	GTEx	Small Intestine Terminal Ileum	RP11-360F5.3	0.16	0.07	lasso	8	0.03	8.9e-02	-4.9	5.9	4.4e-09	-0.02	0.12	0.29	FALSE
36	GTEx	Esophagus Mucosa	RP11-617D20.1	0.29	0.02	enet	35	0.09	2.5e-06	8.2	5.9	4.7e-09	0.68	0.01	0.99	FALSE
9	GTEx	Adipose Visceral Omentum	RP11-360F5.3	0.18	0.13	enet	19	0.13	2.9e-07	-4.9	5.8	5.0e-09	-0.04	1.00	0.00	FALSE
34	GTEx	Esophagus Mucosa	KLHL5	0.20	0.07	enet	23	0.11	1.1e-07	-4.8	-5.8	5.6e-09	-0.17	0.97	0.00	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KLB	0.03	0.00	blup	61	0.01	7.1e-02	6.5	5.8	5.6e-09	-0.12	0.01	0.69	FALSE
77	METSIM	Adipose	WDR19	0.04	0.01	enet	20	0.02	7.7e-04	-6.7	5.8	7.2e-09	0.11	0.68	0.04	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	FAM114A1	0.09	0.05	lasso	7	0.05	2.8e-07	5.3	5.7	1.2e-08	0.22	1.00	0.00	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	WDR19	0.02	0.00	blup	61	0.01	2.8e-02	-3.6	5.7	1.4e-08	-0.03	0.04	0.66	FALSE
5	GTEx	Adipose Subcutaneous	FAM114A1	0.21	0.17	lasso	5	0.17	9.5e-14	4.8	5.5	3.0e-08	0.20	1.00	0.00	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	AC021860.1	0.37	0.05	enet	20	0.12	5.2e-04	-2.5	5.5	3.0e-08	0.42	0.13	0.51	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	RP11-360F5.3	0.07	0.09	lasso	4	0.07	1.8e-09	-4.9	5.5	4.4e-08	-0.02	1.00	0.00	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	TLR6	0.07	0.02	blup	65	0.01	4.7e-02	-6.4	5.4	7.0e-08	0.08	0.01	0.89	FALSE
48	GTEx	Muscle Skeletal	RP11-360F5.3	0.07	0.06	enet	13	0.05	2.1e-05	-4.9	5.3	1.2e-07	0.02	0.95	0.00	FALSE
78	NTR	Blood	KLHL5	0.06	0.01	enet	26	0.04	3.1e-12	-6.1	5.2	1.5e-07	0.20	0.91	0.01	FALSE
24	GTEx	Brain Putamen basal ganglia	RP11-360F5.3	0.24	0.15	enet	44	0.03	8.4e-02	2.6	5.2	2.1e-07	0.06	0.17	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FLJ13197	0.13	0.10	bslmm	608	0.10	8.8e-13	-2.6	5.1	2.9e-07	0.41	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KLHL5	0.17	0.09	enet	18	0.07	1.5e-06	-4.9	-5.1	2.9e-07	0.04	1.00	0.00	FALSE