Hub : Genes

KDR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.5270	0.0640	5.6e-17	0.201	NA	0.267	NA	0.229	4.8e-15	NA	4.2e-20	NA	4.2e-17
2	TCGA	Glioblastoma Multiforme	0.3310	0.1100	3.0e-03	0.005	0.121	0.056	NA	0.001	2.3e-01	0.00017	8.4e-03	NA	2.8e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0534	0.0253	2.1e-03	0.037	0.014	0.031	NA	0.001	4.8e-05	0.01000	1.8e-04	NA	2.2e-01
4	TCGA	Prostate Adenocarcinoma	0.0494	0.0222	5.0e-03	0.021	0.008	0.011	NA	0.018	2.6e-03	0.04000	2.4e-02	NA	5.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.6	0.8	-1.6	0.4	0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	1.7	1.2	-0.1	-0.6	-1.3
Depressed Affect (Nagel 2018)	1.0	2.1	4.4	0.3	-0.7	-2.1	-1.9
Depression (Nagel 2018)	0.1	0.1	0.3	-0.2	0.5	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	-0.5	-0.4	-0.3	-0.5
Neuroticism (Nagel 2018)	0.4	0.8	1.2	0.5	-0.8	-1.1	-1.1
Schizophrenia (2018)	0.8	1.6	3.2	1.0	1.1	-1.0	-1.8
Schizophrenia vs Biploar Disorder	1.6	2.1	3.7	-0.5	1.9	-1.7	-1.2
Worry (Nagel 2018)	0.0	0.0	0.1	0.0	-0.3	-0.0	0.0
Alzheimer’s Disease (in mother)	0.8	0.9	3.1	-0.4	-1.8	-0.6	0.0
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.3	0.3	-0.8	-0.7
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.5	-1.4	-1.0	-0.9
Crohns Disease (2017)	0.4	1.0	1.6	1.3	-0.9	-0.5	-1.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.6	0.4	-0.1	0.1	-1.3
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.4	-0.0	0.4	-0.9
Major Depression (MDD)	0.5	0.6	1.4	0.5	0.9	0.3	-1.2
Reaction Time	1.1	2.1	3.0	-1.7	1.3	-1.4	-1.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.4	-0.8	0.7	0.1
Breast Cancer	1.4	3.5	8.2	1.5	-2.9	1.7	0.7
Ovarian Cancer	1.0	1.3	3.2	0.2	-1.4	1.8	0.3
Prostate Cancer	1.1	1.5	4.9	2.2	-0.9	-0.6	-0.3
Age at First Birth	0.9	1.4	3.0	0.2	-0.7	1.4	1.7
Bipolar Disorder (2011)	0.3	0.3	1.3	-1.1	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	4.6	-0.8	-0.1	0.4	2.1
Coronary Artery Disease (CAD)	0.8	1.0	3.7	0.5	1.9	0.0	0.0
Crohns Disease (2012)	0.3	0.5	0.8	0.9	-0.2	-0.9	-0.7
Mean Putamen Volume	0.4	0.4	1.1	0.5	-1.0	0.1	0.6
Fasting Glucose	2.4	2.8	4.6	1.4	-1.1	-1.9	-2.1
HbA1C	1.3	1.5	3.1	-1.8	-0.4	0.5	1.5
HDL Cholesterol	0.8	1.4	4.9	2.2	0.2	0.7	-0.1
LDL Cholesterol	0.1	0.2	0.5	-0.7	-0.1	-0.2	0.2
Lupus	0.3	0.4	1.2	0.3	0.5	-0.3	1.1
Neuroticism (2016)	0.5	0.7	1.8	-0.4	-1.3	-0.9	-0.2
Primary Biliary Cirrhosis	0.9	1.3	3.9	-1.1	2.0	-0.4	-0.2
Rheumatoid Arthritis	0.7	0.9	2.1	0.1	0.1	1.2	1.5
Schizophrenia (2014)	0.2	0.5	0.9	0.7	-0.5	-0.9	-0.6
Triglycerides	0.6	1.0	2.6	-0.7	-1.6	-0.5	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.6	0.9	0.8	0.1
Ulcerative Colitis	0.7	1.0	1.9	0.4	0.3	-1.3	-1.4
Blood Eosinophil Count	0.4	2.8	9.1	0.4	3.0	0.3	-1.3
Blood Platelet Count	0.6	6.6	14.1	0.5	3.8	-1.9	-2.9
Blood Red Count	1.0	10.0	27.0	5.2	-2.7	-1.6	-1.8
Blood White Count	1.2	9.0	20.5	-1.4	1.6	-3.3	-4.5
Heel T-Score	1.1	9.0	34.0	-1.1	-5.8	-0.7	0.6
BMI	0.1	0.7	1.9	0.7	-1.4	-0.2	0.4
Height	0.1	1.7	4.2	0.1	-1.6	-2.0	-0.5
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.5	0.3	-0.0	0.1
Systolic Blood Pressure	0.7	3.4	9.0	3.0	0.2	1.0	1.8
Smoking Status	1.3	3.1	9.0	-3.0	1.0	-1.5	-0.2
Allergy or Eczema	0.4	1.0	2.7	-1.0	-0.5	0.5	1.6
Cardiovascular Disease	0.8	2.5	8.8	3.0	-0.4	0.8	0.7
Hypothyroidism (self reported)	0.9	2.1	4.0	-2.0	-1.3	-0.9	-1.3
Respiratory disease	1.1	2.4	4.0	1.5	-2.0	1.4	1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	1.6	-1.1	0.3	0.2
Lung FEV1/FVC ratio	0.3	1.4	2.5	0.6	0.6	1.5	-1.6
Lung FVC	4.9	25.2	36.4	-4.0	3.6	-6.0	-6.0
Neuroticism	0.6	1.4	2.6	1.1	-1.6	-1.2	-0.6
Chronotype (morning person)	1.4	3.3	9.6	1.5	-0.1	1.1	3.1
Hair Pigment	0.1	2.4	4.2	0.5	2.0	-1.0	-2.0
Tanning	0.1	1.1	2.0	-1.4	-0.8	1.2	0.6
Hand grip strength (left)	0.2	0.6	1.6	-0.0	-0.7	0.4	1.3
Number of treatments/medications taken	0.2	0.3	0.7	-0.0	0.6	-0.8	-0.5
Average weekly spirits intake	0.8	0.9	2.6	-0.5	1.0	-0.0	-1.6
Sensitivity / hurt feelings	0.3	0.5	1.6	0.2	-0.6	-1.3	-0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	1.1	1.0	-0.6	-0.8
Hearing difficulty/problems: Yes	1.1	1.6	4.6	-2.1	1.2	0.0	-0.7
Relative age of first facial hair	0.4	0.9	3.5	-0.0	0.2	1.9	-0.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.4	-1.3	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	0.1	1.2	-0.5	-0.6
Ever had hysterectomy (womb removed)	1.0	1.2	3.3	0.3	-1.8	-1.1	0.4
Systolic blood pressure, automated reading	0.3	0.9	2.4	0.4	0.8	0.5	1.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	-0.3	1.2	1.4	0.9
Angina	1.3	1.7	3.8	-0.0	-1.0	-1.9	-1.4
Medication for hormone replacement therapy	0.3	0.4	0.7	0.8	0.6	-0.3	-0.6
Vitamin and mineral supplements	0.7	1.0	2.6	-0.7	0.0	-1.6	-0.9
Supplements: Zinc	2.4	2.6	6.9	-2.6	0.9	1.5	0.7
Medication: Co-codamol	1.0	1.1	2.5	-1.3	0.6	-1.6	0.0
Medication: Metformin	0.2	0.2	0.6	0.1	-0.8	-0.5	0.3
Diabetes (father)	1.2	1.5	4.3	1.1	0.6	2.1	0.3
Diabetes (mother)	0.4	0.5	1.2	0.2	0.2	-0.9	-1.1
Severe depression (siblings)	0.6	0.6	1.8	-1.4	0.1	0.8	-0.1
Pack years adult smoking proportion	0.5	0.8	1.8	1.0	-1.3	-0.4	-0.6
Impedance of leg (right)	0.5	2.2	4.7	1.0	1.0	-1.4	-2.2
Leg fat-free mass (left)	0.2	0.9	2.5	0.4	-1.6	0.0	1.0
Trunk fat percentage	0.1	0.6	0.9	-0.4	-0.9	-0.8	-0.7
Hand grip strength (right)	0.3	0.7	1.2	0.6	-1.1	0.1	1.1
Townsend deprivation index at recruitment	0.2	0.3	1.1	-1.1	0.3	0.4	-0.2
Current tobacco smoking	0.9	1.5	2.4	-1.5	0.3	-1.2	-1.4
Average weekly fortified wine intake	0.7	0.8	3.3	1.8	0.1	0.1	-0.1
Maternal smoking around birth	0.3	0.4	0.9	0.9	-0.0	-0.3	-0.8
Fed-up feelings	1.9	3.5	7.0	-0.7	-0.1	-2.6	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-1.0	0.3	0.7	0.1
Relative age voice broke	0.7	1.0	2.3	-1.1	-0.1	1.5	0.7
Taking other prescription medications	0.9	1.3	3.1	0.2	0.1	-1.5	-1.8
Age when periods started (menarche)	0.2	0.5	1.0	0.7	-0.4	1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.6	-0.1	0.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	13.1	-1.2	-3.6	-0.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	-0.1	0.7	-0.1
Qualifications: CSEs or equivalent	0.7	1.0	2.0	-0.3	-0.7	-1.2	-1.4
Serious illness, injury or assault to yourself	0.1	0.2	0.3	-0.3	-0.5	0.4	-0.2
High blood pressure	0.6	1.7	4.7	2.2	1.3	-0.1	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	-1.0	-0.0	0.1	1.1
Multivitamins +/- minerals	0.6	0.8	1.9	0.9	0.3	1.4	0.5
Stomach or abdominal pain in last month	1.3	1.6	4.4	-2.1	-0.5	-1.3	0.0
Supplements: Glucosamine	0.3	0.3	0.4	-0.4	-0.6	0.6	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	-0.1	0.3	0.1
Medication: Atenolol	1.3	1.6	4.1	0.9	0.5	-2.0	-1.2
Medication: Levothyroxine sodium	3.9	6.5	11.2	-2.5	1.0	-3.3	-2.7
Sitting height	0.3	2.0	3.3	1.8	-1.6	-0.9	1.1
Chronic bronchitis/emphysema (father)	1.2	1.4	4.4	-2.1	-1.1	0.0	0.4
High blood pressure (mother)	0.4	0.6	1.0	0.2	0.8	1.0	0.7
Body mass index (BMI)	0.1	0.4	1.5	0.1	-1.2	0.0	0.4
Impedance of leg (left)	0.3	1.3	3.1	1.3	0.5	-0.6	-1.8
Leg predicted mass (left)	0.2	1.0	2.6	0.4	-1.6	0.1	1.1
Trunk fat mass	0.2	0.7	2.6	-0.1	-1.6	-0.6	-0.2
Waist circumference	0.1	0.2	0.5	-0.7	-0.5	-0.2	0.0
Number of incorrect matches in round	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4
Past tobacco smoking	1.6	3.0	5.7	2.2	-0.8	2.4	0.8
Alcohol usually taken with meals	0.4	0.7	1.7	-0.6	0.1	1.3	0.9
Nervous feelings	0.5	0.9	2.0	-1.4	0.9	-0.5	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	-0.8	0.3	-0.8	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.1	-0.4	-0.7	-1.2
Hair/balding pattern: Pattern 2	2.3	2.9	7.3	1.7	-2.7	-0.0	1.1
Had menopause	0.4	0.5	1.2	0.1	1.1	-0.8	-0.3
Had other major operations	0.4	0.5	0.9	-0.4	-0.9	-1.0	0.3
Forced vital capacity (FVC)	2.9	11.2	21.0	-1.6	2.0	-4.6	-4.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	10.6	-1.5	-3.2	-0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.1	-0.3	1.3	0.8
Qualifications: None of the above	0.3	0.5	1.0	-1.0	-0.4	-1.0	0.2
Financial difficulties in last 2 years	0.4	0.5	1.5	-1.2	-0.0	-0.6	-0.0
Mouth/teeth dental problems	0.1	0.2	0.6	0.8	-0.5	-0.3	-0.2
Heart attack	0.5	0.6	1.6	-0.2	0.2	-1.3	-1.0
Allergy	0.6	1.3	3.5	0.7	0.7	-0.9	-1.9
Pain all over the body in last month	0.3	0.3	0.9	-0.1	0.0	0.4	-1.0
Diabetes (self-reported)	0.0	0.1	0.2	-0.0	-0.4	0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	-1.1	1.6	0.9	0.1
Medication: Ramipril	1.4	1.8	6.8	2.6	-0.4	0.0	0.4
Medication: Simvastatin	0.4	0.6	2.3	-0.4	-0.3	-1.5	-0.1
Fluid intelligence score	0.1	0.2	0.7	0.1	0.8	0.4	0.0
Illnesses of siblings	1.5	2.1	4.8	2.2	1.0	1.6	0.2
Neuroticism score	0.5	1.1	3.0	0.4	-0.6	-1.7	-0.9
Weight	0.2	1.0	3.1	0.5	-1.8	-0.6	0.6
Impedance of arm (right)	0.9	4.3	5.8	-2.4	2.3	-1.5	-2.0
Arm fat percentage (right)	0.2	1.0	2.4	-1.6	-0.8	-0.7	-0.4
Trunk fat-free mass	0.5	2.7	5.9	1.5	-2.4	0.0	1.6
Hip circumference	0.1	0.4	1.4	0.0	-1.2	-0.5	-0.2
Time employed in main current job	1.6	1.9	4.7	0.2	2.2	-1.2	-1.2
Alcohol intake versus 10 years previously	1.5	2.3	3.9	1.2	-0.6	-2.0	-1.8
Father’s age at death	1.4	1.9	5.4	-2.3	0.9	-0.3	1.1
Worrier / anxious feelings	0.4	0.7	1.5	-0.2	-0.4	-1.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.2	1.8	-0.6	-2.1	-2.3
Falls in the last year	0.8	1.1	2.0	-1.4	1.3	0.9	0.2
Hair/balding pattern: Pattern 3	3.5	5.3	8.4	-1.8	2.5	-1.8	-2.9
Number of live births	0.5	0.7	1.2	-0.8	1.1	-0.8	0.5
Forced expiratory volume in 1-second (FEV1)	2.4	8.0	16.9	-0.9	1.9	-3.2	-4.1
Pulse rate	1.3	2.2	4.7	-1.1	2.2	0.0	-1.7
Happiness	1.0	1.2	4.3	0.1	0.5	2.1	0.6
Noisy workplace	0.9	1.1	4.4	-2.1	0.2	-0.4	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	0.5	-0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	1.8	-0.8	1.1	0.7
Mouth/teeth dental problems: Dentures	2.0	3.4	8.1	-1.5	2.8	1.8	-0.3
Asthma	1.9	3.8	6.3	0.2	-1.7	2.5	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	1.0	-1.8	0.4	0.8
Medication: Cholesterol lowering	1.4	2.2	5.7	0.0	-1.5	-2.4	-1.0
Depression (self-reported)	0.9	1.0	2.9	1.7	-0.4	0.1	-1.0
Medication: Lansoprazole	0.2	0.2	0.7	0.9	0.3	0.2	-0.1
Prospective memory result	0.6	0.7	2.0	0.4	-0.8	-0.4	1.4
Lung cancer (father)	1.4	1.6	4.0	-0.9	2.0	1.3	0.1
Illnesses of mother	0.4	0.5	0.9	-0.0	0.8	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	12.9	-1.3	2.1	-2.7	-3.6
Pulse wave Arterial Stiffness index	0.5	0.5	1.1	-0.9	-1.0	0.3	0.4
Impedance of arm (left)	0.8	3.5	4.2	-1.9	1.9	-1.7	-2.0
Arm fat mass (right)	0.2	0.7	2.2	-0.4	-1.5	-0.4	0.3
Trunk predicted mass	0.5	2.8	6.1	1.6	-2.5	0.1	1.6
Standing height	0.1	1.5	2.4	1.4	-1.6	-1.1	0.6
Length of working week for main job	0.8	0.9	1.7	0.9	-0.1	1.3	1.0
Exposure to tobacco smoke at home	1.0	1.1	2.7	1.3	-1.6	-0.3	0.1
Breastfed as a baby	2.4	2.9	7.5	-0.4	-1.9	-2.7	-0.7
Tense / ‘highly strung’	0.2	0.3	0.9	0.2	-0.4	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.3	-0.4	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	-0.3	1.3	0.7	0.1
Birth weight of first child	0.8	1.4	4.7	-0.3	-0.8	-2.2	0.5
Peak expiratory flow (PEF)	1.3	3.0	7.9	1.2	0.9	-1.3	-2.8
Pulse wave reflection index	1.1	1.4	2.7	-1.0	-1.6	0.8	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.9	-0.5	1.4	-1.4	-0.8
Loud music exposure frequency	1.2	1.3	4.2	0.0	-2.0	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	3.0	1.3	-0.7	1.5	1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.1	0.6	-0.9	0.3
Blood clot in the leg (DVT)	0.9	1.1	2.7	-0.7	0.3	-1.6	-1.2
Medication: Paracetamol	1.1	1.9	4.4	-1.4	-0.4	1.0	2.1
Headache pain in last month	1.8	3.0	6.3	-2.5	2.1	-0.6	-0.9
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	5.4	-0.8	0.9	2.3	1.0
Glaucoma (self-reported)	0.5	0.5	1.4	0.5	-0.1	-0.7	-1.2
Gout (self-reported)	0.2	0.3	0.8	-0.9	0.7	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	2.3	4.6	7.3	-2.1	0.2	-2.7	-2.5
Medication: Amlodipine	0.2	0.3	0.7	0.6	0.0	-0.5	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.7	1.6	-1.4	0.2	-1.0
Birth weight	0.5	1.1	2.9	-1.7	0.1	-0.5	1.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	-0.7	-0.7	-1.5	-1.7
High blood pressure (siblings)	1.1	1.5	3.0	-1.2	-0.8	-1.7	-1.0
Forced vital capacity (FVC), Best measure	2.7	9.8	17.5	-1.7	2.3	-4.2	-3.6
Body fat percentage	0.1	0.4	0.8	-0.4	-0.9	-0.6	-0.4
Leg fat percentage (right)	0.2	0.6	1.1	0.3	-0.8	-0.7	-1.1
Arm fat-free mass (right)	0.8	4.0	8.3	2.3	-2.9	0.4	1.4
Exposure to tobacco smoke outside home	0.4	0.5	1.7	0.3	-1.3	-0.6	-0.2
Comparative body size at age 10	0.3	0.9	1.8	0.4	-1.4	0.1	1.3
Number of full brothers	0.7	0.8	2.5	-0.9	0.0	-1.6	-0.4
Worry too long after embarrassment	0.8	1.4	2.1	1.5	1.2	-0.8	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.0	-0.9	-0.6	-1.1	-1.4
Wheeze or whistling in the chest in last year	0.7	1.2	4.3	-0.5	-2.1	-0.3	0.5
Number of children fathered	0.2	0.3	0.5	0.2	0.7	-0.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	5.1	-0.4	-2.2	-0.2	0.3
Age at first live birth	0.6	1.1	3.7	-0.6	1.9	-0.6	-0.3
Pulse wave peak to peak time	0.5	0.6	1.3	1.2	0.9	-0.4	-0.3
Health satisfaction	0.6	0.8	2.9	-1.7	-0.3	-0.0	-0.0
Shortness of breath walking on level ground	1.0	1.1	2.2	-0.8	-0.4	-1.5	-1.3
Qualifications: College or University degree	0.1	0.2	0.5	0.1	-0.7	0.5	0.2
Eye problems/disorders: None of the above	2.1	2.4	4.8	-2.2	1.7	-0.5	-1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-1.2	-0.2	0.4	0.9
Emphysema/chronic bronchitis	1.5	1.6	3.3	0.4	-1.8	1.7	-0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	3.3	0.9	1.3	0.1	-1.8
Neck or shoulder pain in last month	0.3	0.5	1.3	-0.7	0.3	-1.2	-0.4
Medication: Blood pressure	1.7	3.0	8.1	1.4	-1.0	-2.8	-1.1
Angina (self-reported)	1.0	1.3	3.1	-0.1	-0.9	-1.8	-1.2
Migraine (self-reported)	3.4	4.2	7.2	-2.0	1.0	-2.7	-2.1
Medication: Ibuprofen	1.9	2.3	2.9	1.6	-1.5	1.7	1.0
Medication: Allopurinol	1.8	2.4	6.0	-1.8	2.4	-0.6	-0.6
Medication: Omeprazole	0.8	1.0	2.0	-1.4	0.0	-1.1	-0.8
Medication: Seretide 50 evohaler	0.5	0.5	1.5	0.3	-0.7	1.2	0.1
Mean time to correctly identify matches	1.3	2.5	5.1	-2.2	1.4	-1.1	-1.3
Heart disease (mother)	0.2	0.3	0.9	0.9	-0.3	0.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.6	-0.8	-1.0	1.3	1.9
Whole body fat mass	0.2	0.6	2.2	0.1	-1.5	-0.6	-0.1
Leg fat mass (right)	0.1	0.5	1.4	0.2	-1.2	-0.5	-0.4
Arm predicted mass (right)	0.9	4.5	9.5	2.5	-3.1	0.6	1.5
Pulse rate, automated reading	0.9	2.8	7.7	-0.5	2.8	-0.2	-1.8
Alcohol intake frequency.	0.1	0.3	1.1	-0.3	1.1	0.0	-0.4
Comparative height size at age 10	0.3	1.6	5.0	1.1	-0.6	-2.2	-0.1
Number of full sisters	1.0	1.2	2.4	-1.6	0.7	-0.2	-1.4
Suffer from ‘nerves’	0.8	1.2	2.9	0.2	-0.7	1.2	1.7
Overall health rating	0.6	1.3	3.0	0.3	-0.3	-1.7	-1.4
Chest pain or discomfort	0.7	1.0	3.2	0.2	-1.8	-0.7	-0.5
Had major operations	4.1	4.9	17.8	0.6	-4.2	-0.5	1.0
Age at last live birth	0.5	0.7	1.5	-1.2	0.4	-0.8	0.5
Family relationship satisfaction	0.5	0.6	0.9	0.8	0.4	1.0	0.9
Leg pain on walking	1.4	1.8	3.8	1.1	-1.1	2.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-1.4	-0.0	0.0	0.8
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.8	-0.1	-1.9	-0.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.7	0.8	-1.0	-0.3
Medication: Aspirin	0.7	0.9	1.4	-0.8	-1.2	-0.3	1.1
Supplements: Vitamin C	0.3	0.4	0.7	-0.8	0.1	0.8	0.5
Knee pain experienced in last month	0.1	0.2	0.8	-0.1	-0.3	-0.0	-0.9
Hypertension (Self-reported)	0.5	1.5	4.2	2.1	0.9	-0.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.2	-0.4	-1.0	-1.1	-1.1
Illnesses of father: Heart disease	1.7	2.3	6.8	2.6	-1.1	-0.2	-1.1
Illnesses of siblings: Diabetes	1.7	2.1	6.4	-2.5	-0.1	-1.1	-0.7
Smoking status: Previous	1.2	1.8	3.8	-2.0	1.1	-1.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.3	1.1	-0.6	0.1	1.0
Whole body fat-free mass	0.4	2.3	5.7	1.2	-2.4	0.1	1.4
Leg fat-free mass (right)	0.3	1.5	3.4	0.5	-1.8	0.5	1.4
Arm fat percentage (left)	0.2	0.8	1.6	-1.3	-1.0	-0.8	-0.4
Average weekly red wine intake	1.3	2.0	7.6	0.5	-2.8	-0.0	0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.7	-1.0	2.2	-0.2	-0.7
Mood swings	1.0	1.8	4.4	0.5	-0.3	-2.1	-1.6
Loneliness, isolation	0.2	0.2	0.4	-0.3	0.5	-0.6	0.3
Long-standing illness, disability or infirmity	0.7	1.1	2.7	0.6	-0.4	-1.2	-1.6
Ever had bowel cancer screening	0.5	0.6	1.1	-1.1	0.7	-0.7	0.1
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.3	-1.0	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	0.1	1.5	-0.4	-0.3
Friendships satisfaction	1.1	1.4	2.5	-0.5	1.1	-1.6	-1.2
Qualifications: nursing, teaching	0.7	1.0	2.0	-0.5	-0.5	-1.3	-1.4
Commuting to job workplace: Walk	2.3	2.5	3.7	-1.9	-0.5	-1.9	-1.5
Eye problems/disorders: Cataract	1.5	1.8	2.8	1.3	-1.6	0.4	1.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	1.2	0.8	0.0	0.1
Medication for cholesterol	0.5	0.8	1.2	-0.9	-0.8	-1.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.9	4.6	9.0	1.7	0.8	-2.4	-3.0
Back pain experienced in last month	0.1	0.1	0.3	0.6	-0.3	0.2	-0.1
Mineral and other dietary supplements	1.1	1.4	2.5	0.4	1.1	-1.6	-1.4
Breast cancer (self-reported)	1.2	1.5	2.2	1.4	-0.7	-1.1	-1.5
Asthma (self-reported)	1.9	3.7	6.0	0.1	-1.8	2.4	2.4
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.8	0.3	0.1	1.2
Osteoarthritis (self-reported)	1.5	2.0	5.3	-0.7	-0.7	-1.3	-2.3
Medication: Aspirin	0.4	0.5	1.3	-0.5	-0.7	-0.1	1.1
Medication: Gliclazide	0.2	0.2	0.7	0.1	0.3	-0.8	-0.1
Illnesses of father: None of the above (group 1)	1.0	1.3	2.4	-1.5	1.4	-0.9	-0.2
Smoking status: Current	1.0	1.5	2.4	-1.6	0.6	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	8.7	-1.3	2.3	-0.7	-2.9
Whole body water mass	0.4	2.4	5.5	1.2	-2.3	0.3	1.6
Leg predicted mass (right)	0.3	1.5	3.3	0.4	-1.8	0.5	1.4
Arm fat mass (left)	0.2	0.6	2.2	-0.1	-1.5	-0.5	-0.0
Number of self-reported non-cancer illnesses	0.4	0.7	2.0	-0.5	-0.5	-1.4	-0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.5
Miserableness	2.0	3.4	7.3	0.4	-0.1	-2.7	-2.5
Guilty feelings	0.4	0.6	1.1	-0.8	0.7	0.0	1.1
Wears glasses or contact lenses	1.2	1.4	2.8	-1.7	0.2	-1.4	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	-0.5	-0.8	-0.1
Hearing aid user	3.0	3.4	7.4	0.3	-0.3	2.7	2.4
Mother’s age at death	0.9	1.1	2.2	-0.3	0.9	-1.1	-1.5
Financial situation satisfaction	1.8	2.3	3.6	-1.9	1.9	0.4	-1.4
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	-0.1	0.3	-0.1	0.2
Commuting to job workplace: Public transport	1.4	1.7	3.5	0.4	1.1	-1.3	-1.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.8	-0.3	-0.1	-0.1
Medication: Blood pressure	1.1	2.1	3.3	0.5	1.6	1.8	1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.2	1.0	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	1.1	-0.1	0.1	0.1
High cholesterol (Self-reported)	0.1	0.2	0.4	0.3	-0.6	-0.4	0.1
Medication: Bendroflumethiazide	0.6	0.9	1.6	-1.1	1.2	-0.3	0.7
Medication: Paracetamol	1.7	2.6	6.9	-1.3	-0.4	1.3	2.6
Medication: Lisinopril	1.1	1.4	2.9	0.4	-1.0	-1.7	-1.2
Medication: Atorvastatin	4.1	5.1	7.2	2.2	1.1	-2.7	-2.6
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	-0.5	0.2	-0.2
Alcohol drinker status: Never	0.1	0.1	0.5	0.2	0.2	-0.2	-0.7
Ever smoked	1.5	2.6	6.5	-1.5	0.0	-2.5	-1.2
Basal metabolic rate	0.3	1.9	4.9	1.2	-2.2	0.0	1.2
Leg fat percentage (left)	0.2	0.6	1.3	0.5	-1.1	-0.3	-0.9
Arm fat-free mass (left)	0.7	3.5	7.5	2.2	-2.7	0.3	1.3
Number of operations (self-reported)	1.3	1.9	5.7	0.6	-2.4	-0.9	0.8
Average weekly beer plus cider intake	0.9	1.3	3.9	0.2	1.2	-0.3	-2.0
Irritability	0.5	0.8	2.0	0.6	-1.4	-0.7	-0.7
Risk taking	0.3	0.4	1.3	-1.2	-0.0	-0.1	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.1	-0.2	-0.5	0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.3	-0.9	0.1	0.1
Age started oral contraceptive pill	0.8	1.1	1.9	-1.4	-0.4	1.1	0.9
Diastolic blood pressure, automated reading	0.1	0.3	0.4	-0.2	0.7	0.4	0.6
Ever depressed for a whole week	0.8	1.0	2.2	-0.4	-1.5	0.8	1.0
Unable to work because of sickness or disability	0.6	0.8	1.5	-0.3	-0.9	-0.8	-1.2
Commuting to job workplace: Cycle	0.9	1.0	1.4	1.2	-0.9	1.1	0.9
Myopia	1.9	2.7	4.0	-1.5	1.0	-1.9	-2.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.0	-1.7	-0.7	0.5	-0.2
Cholesterol lowering medication	1.2	1.8	4.6	0.4	2.1	-0.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	-0.8	-0.4	-0.3	-0.3
Pain experienced in last month	0.4	0.7	1.8	0.1	-1.4	-0.4	0.8
Supplements: Calcium	0.4	0.4	0.8	-0.9	0.7	-0.1	-0.6
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	-0.3	1.1	1.2	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	-0.2	0.1	-1.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.6	-0.1	-1.2	-0.6
Heart disease (siblings)	0.6	0.8	1.4	-1.2	-0.2	-1.0	-0.8
Alcohol drinker status: Previous	0.5	0.6	1.2	-0.8	-0.5	1.1	0.7
Pack years of smoking	0.4	0.5	1.1	0.8	-1.0	-0.3	-0.6
Impedance of whole body	0.4	2.0	4.3	-0.4	1.6	-1.0	-2.1
Leg fat mass (left)	0.1	0.5	1.9	0.3	-1.4	-0.3	-0.3
Arm predicted mass (left)	0.5	2.7	5.6	2.0	-2.4	0.2	1.1