TWAS hub - KDR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.5270	0.0640	5.6e-17	0.201	NA	0.267	NA	0.229	4.8e-15	NA	4.2e-20	NA	4.2e-17
2	TCGA	Glioblastoma Multiforme	0.3310	0.1100	3.0e-03	0.005	0.121	0.056	NA	0.001	2.3e-01	0.00017	8.4e-03	NA	2.8e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0534	0.0253	2.1e-03	0.037	0.014	0.031	NA	0.001	4.8e-05	0.01000	1.8e-04	NA	2.2e-01
4	TCGA	Prostate Adenocarcinoma	0.0494	0.0222	5.0e-03	0.021	0.008	0.011	NA	0.018	2.6e-03	0.04000	2.4e-02	NA	5.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Lung FVC	4.9	25.2	36.4	-4.0	3.6	-6.0	-6.0
Had major operations	4.1	4.9	17.8	0.6	-4.2	-0.5	1.0
Medication: Atorvastatin	4.1	5.1	7.2	2.2	1.1	-2.7	-2.6
Medication: Levothyroxine sodium	3.9	6.5	11.2	-2.5	1.0	-3.3	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.9	4.6	9.0	1.7	0.8	-2.4	-3.0
Hair/balding pattern: Pattern 3	3.5	5.3	8.4	-1.8	2.5	-1.8	-2.9
Migraine (self-reported)	3.4	4.2	7.2	-2.0	1.0	-2.7	-2.1
Hearing aid user	3.0	3.4	7.4	0.3	-0.3	2.7	2.4
Forced vital capacity (FVC)	2.9	11.2	21.0	-1.6	2.0	-4.6	-4.1
Forced vital capacity (FVC), Best measure	2.7	9.8	17.5	-1.7	2.3	-4.2	-3.6
Fasting Glucose	2.4	2.8	4.6	1.4	-1.1	-1.9	-2.1
Supplements: Zinc	2.4	2.6	6.9	-2.6	0.9	1.5	0.7
Forced expiratory volume in 1-second (FEV1)	2.4	8.0	16.9	-0.9	1.9	-3.2	-4.1
Breastfed as a baby	2.4	2.9	7.5	-0.4	-1.9	-2.7	-0.7
Hair/balding pattern: Pattern 2	2.3	2.9	7.3	1.7	-2.7	-0.0	1.1
Hypothyroidism/myxoedema (self-reported)	2.3	4.6	7.3	-2.1	0.2	-2.7	-2.5
Commuting to job workplace: Walk	2.3	2.5	3.7	-1.9	-0.5	-1.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	12.9	-1.3	2.1	-2.7	-3.6
Eye problems/disorders: None of the above	2.1	2.4	4.8	-2.2	1.7	-0.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.2	1.8	-0.6	-2.1	-2.3
Mouth/teeth dental problems: Dentures	2.0	3.4	8.1	-1.5	2.8	1.8	-0.3
Miserableness	2.0	3.4	7.3	0.4	-0.1	-2.7	-2.5
Fed-up feelings	1.9	3.5	7.0	-0.7	-0.1	-2.6	-2.5
Asthma	1.9	3.8	6.3	0.2	-1.7	2.5	2.5
Medication: Ibuprofen	1.9	2.3	2.9	1.6	-1.5	1.7	1.0
Asthma (self-reported)	1.9	3.7	6.0	0.1	-1.8	2.4	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	8.7	-1.3	2.3	-0.7	-2.9
Myopia	1.9	2.7	4.0	-1.5	1.0	-1.9	-2.0
Headache pain in last month	1.8	3.0	6.3	-2.5	2.1	-0.6	-0.9
Medication: Allopurinol	1.8	2.4	6.0	-1.8	2.4	-0.6	-0.6
Financial situation satisfaction	1.8	2.3	3.6	-1.9	1.9	0.4	-1.4
Medication: Blood pressure	1.7	3.0	8.1	1.4	-1.0	-2.8	-1.1
Illnesses of father: Heart disease	1.7	2.3	6.8	2.6	-1.1	-0.2	-1.1
Illnesses of siblings: Diabetes	1.7	2.1	6.4	-2.5	-0.1	-1.1	-0.7
Medication: Paracetamol	1.7	2.6	6.9	-1.3	-0.4	1.3	2.6
Schizophrenia vs Biploar Disorder	1.6	2.1	3.7	-0.5	1.9	-1.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	13.1	-1.2	-3.6	-0.5	0.1
Past tobacco smoking	1.6	3.0	5.7	2.2	-0.8	2.4	0.8
Time employed in main current job	1.6	1.9	4.7	0.2	2.2	-1.2	-1.2
Illnesses of siblings	1.5	2.1	4.8	2.2	1.0	1.6	0.2
Alcohol intake versus 10 years previously	1.5	2.3	3.9	1.2	-0.6	-2.0	-1.8
Emphysema/chronic bronchitis	1.5	1.6	3.3	0.4	-1.8	1.7	-0.2
Eye problems/disorders: Cataract	1.5	1.8	2.8	1.3	-1.6	0.4	1.7
Osteoarthritis (self-reported)	1.5	2.0	5.3	-0.7	-0.7	-1.3	-2.3
Ever smoked	1.5	2.6	6.5	-1.5	0.0	-2.5	-1.2
Breast Cancer	1.4	3.5	8.2	1.5	-2.9	1.7	0.7
Chronotype (morning person)	1.4	3.3	9.6	1.5	-0.1	1.1	3.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	10.6	-1.5	-3.2	-0.2	-0.2
Medication: Ramipril	1.4	1.8	6.8	2.6	-0.4	0.0	0.4
Father’s age at death	1.4	1.9	5.4	-2.3	0.9	-0.3	1.1
Medication: Cholesterol lowering	1.4	2.2	5.7	0.0	-1.5	-2.4	-1.0
Lung cancer (father)	1.4	1.6	4.0	-0.9	2.0	1.3	0.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	-0.7	-0.7	-1.5	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.6	-0.8	-1.0	1.3	1.9
Leg pain on walking	1.4	1.8	3.8	1.1	-1.1	2.0	1.0
Commuting to job workplace: Public transport	1.4	1.7	3.5	0.4	1.1	-1.3	-1.9
HbA1C	1.3	1.5	3.1	-1.8	-0.4	0.5	1.5
Smoking Status	1.3	3.1	9.0	-3.0	1.0	-1.5	-0.2
Angina	1.3	1.7	3.8	-0.0	-1.0	-1.9	-1.4
Stomach or abdominal pain in last month	1.3	1.6	4.4	-2.1	-0.5	-1.3	0.0
Medication: Atenolol	1.3	1.6	4.1	0.9	0.5	-2.0	-1.2
Pulse rate	1.3	2.2	4.7	-1.1	2.2	0.0	-1.7
Peak expiratory flow (PEF)	1.3	3.0	7.9	1.2	0.9	-1.3	-2.8
Mean time to correctly identify matches	1.3	2.5	5.1	-2.2	1.4	-1.1	-1.3
Average weekly red wine intake	1.3	2.0	7.6	0.5	-2.8	-0.0	0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.7	-1.0	2.2	-0.2	-0.7
Number of operations (self-reported)	1.3	1.9	5.7	0.6	-2.4	-0.9	0.8
Blood White Count	1.2	9.0	20.5	-1.4	1.6	-3.3	-4.5
Diabetes (father)	1.2	1.5	4.3	1.1	0.6	2.1	0.3
Chronic bronchitis/emphysema (father)	1.2	1.4	4.4	-2.1	-1.1	0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	1.8	-0.8	1.1	0.7
Loud music exposure frequency	1.2	1.3	4.2	0.0	-2.0	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	3.0	1.3	-0.7	1.5	1.7
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	5.4	-0.8	0.9	2.3	1.0
Smoking status: Previous	1.2	1.8	3.8	-2.0	1.1	-1.6	-0.1
Breast cancer (self-reported)	1.2	1.5	2.2	1.4	-0.7	-1.1	-1.5
Wears glasses or contact lenses	1.2	1.4	2.8	-1.7	0.2	-1.4	-1.0
Cholesterol lowering medication	1.2	1.8	4.6	0.4	2.1	-0.8	-1.4
Reaction Time	1.1	2.1	3.0	-1.7	1.3	-1.4	-1.4
Prostate Cancer	1.1	1.5	4.9	2.2	-0.9	-0.6	-0.3
Heel T-Score	1.1	9.0	34.0	-1.1	-5.8	-0.7	0.6
Respiratory disease	1.1	2.4	4.0	1.5	-2.0	1.4	1.2
Hearing difficulty/problems: Yes	1.1	1.6	4.6	-2.1	1.2	0.0	-0.7
Pulse wave reflection index	1.1	1.4	2.7	-1.0	-1.6	0.8	1.1
Medication: Paracetamol	1.1	1.9	4.4	-1.4	-0.4	1.0	2.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.7	1.6	-1.4	0.2	-1.0
High blood pressure (siblings)	1.1	1.5	3.0	-1.2	-0.8	-1.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	5.1	-0.4	-2.2	-0.2	0.3
Friendships satisfaction	1.1	1.4	2.5	-0.5	1.1	-1.6	-1.2
Mineral and other dietary supplements	1.1	1.4	2.5	0.4	1.1	-1.6	-1.4
Medication: Blood pressure	1.1	2.1	3.3	0.5	1.6	1.8	1.5
Medication: Lisinopril	1.1	1.4	2.9	0.4	-1.0	-1.7	-1.2
Depressed Affect (Nagel 2018)	1.0	2.1	4.4	0.3	-0.7	-2.1	-1.9
Ovarian Cancer	1.0	1.3	3.2	0.2	-1.4	1.8	0.3
Body Mass Index (BMI) (2010)	1.0	1.3	4.6	-0.8	-0.1	0.4	2.1
Blood Red Count	1.0	10.0	27.0	5.2	-2.7	-1.6	-1.8
Ever had hysterectomy (womb removed)	1.0	1.2	3.3	0.3	-1.8	-1.1	0.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	-0.3	1.2	1.4	0.9
Medication: Co-codamol	1.0	1.1	2.5	-1.3	0.6	-1.6	0.0
Happiness	1.0	1.2	4.3	0.1	0.5	2.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	1.0	-1.8	0.4	0.8
Exposure to tobacco smoke at home	1.0	1.1	2.7	1.3	-1.6	-0.3	0.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.9	-0.5	1.4	-1.4	-0.8
Shortness of breath walking on level ground	1.0	1.1	2.2	-0.8	-0.4	-1.5	-1.3
Angina (self-reported)	1.0	1.3	3.1	-0.1	-0.9	-1.8	-1.2
Number of full sisters	1.0	1.2	2.4	-1.6	0.7	-0.2	-1.4
Mood swings	1.0	1.8	4.4	0.5	-0.3	-2.1	-1.6
Illnesses of father: None of the above (group 1)	1.0	1.3	2.4	-1.5	1.4	-0.9	-0.2
Smoking status: Current	1.0	1.5	2.4	-1.6	0.6	-1.4	-1.2
Age at First Birth	0.9	1.4	3.0	0.2	-0.7	1.4	1.7
Primary Biliary Cirrhosis	0.9	1.3	3.9	-1.1	2.0	-0.4	-0.2
Hypothyroidism (self reported)	0.9	2.1	4.0	-2.0	-1.3	-0.9	-1.3
Current tobacco smoking	0.9	1.5	2.4	-1.5	0.3	-1.2	-1.4
Taking other prescription medications	0.9	1.3	3.1	0.2	0.1	-1.5	-1.8
Impedance of arm (right)	0.9	4.3	5.8	-2.4	2.3	-1.5	-2.0
Noisy workplace	0.9	1.1	4.4	-2.1	0.2	-0.4	0.1
Depression (self-reported)	0.9	1.0	2.9	1.7	-0.4	0.1	-1.0
Blood clot in the leg (DVT)	0.9	1.1	2.7	-0.7	0.3	-1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.0	-0.9	-0.6	-1.1	-1.4
Arm predicted mass (right)	0.9	4.5	9.5	2.5	-3.1	0.6	1.5
Pulse rate, automated reading	0.9	2.8	7.7	-0.5	2.8	-0.2	-1.8
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.8	-0.1	-1.9	-0.0	0.6
Mother’s age at death	0.9	1.1	2.2	-0.3	0.9	-1.1	-1.5
Average weekly beer plus cider intake	0.9	1.3	3.9	0.2	1.2	-0.3	-2.0
Commuting to job workplace: Cycle	0.9	1.0	1.4	1.2	-0.9	1.1	0.9
Schizophrenia (2018)	0.8	1.6	3.2	1.0	1.1	-1.0	-1.8
Alzheimer’s Disease (in mother)	0.8	0.9	3.1	-0.4	-1.8	-0.6	0.0
Coronary Artery Disease (CAD)	0.8	1.0	3.7	0.5	1.9	0.0	0.0
HDL Cholesterol	0.8	1.4	4.9	2.2	0.2	0.7	-0.1
Cardiovascular Disease	0.8	2.5	8.8	3.0	-0.4	0.8	0.7
Average weekly spirits intake	0.8	0.9	2.6	-0.5	1.0	-0.0	-1.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	-1.1	1.6	0.9	0.1
Falls in the last year	0.8	1.1	2.0	-1.4	1.3	0.9	0.2
Impedance of arm (left)	0.8	3.5	4.2	-1.9	1.9	-1.7	-2.0
Length of working week for main job	0.8	0.9	1.7	0.9	-0.1	1.3	1.0
Birth weight of first child	0.8	1.4	4.7	-0.3	-0.8	-2.2	0.5
Arm fat-free mass (right)	0.8	4.0	8.3	2.3	-2.9	0.4	1.4
Worry too long after embarrassment	0.8	1.4	2.1	1.5	1.2	-0.8	-1.2
Medication for pain relief, constipation, heartburn	0.8	1.4	3.3	0.9	1.3	0.1	-1.8
Medication: Omeprazole	0.8	1.0	2.0	-1.4	0.0	-1.1	-0.8
Suffer from ‘nerves’	0.8	1.2	2.9	0.2	-0.7	1.2	1.7
Age started oral contraceptive pill	0.8	1.1	1.9	-1.4	-0.4	1.1	0.9
Ever depressed for a whole week	0.8	1.0	2.2	-0.4	-1.5	0.8	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.5	-1.4	-1.0	-0.9
Rheumatoid Arthritis	0.7	0.9	2.1	0.1	0.1	1.2	1.5
Ulcerative Colitis	0.7	1.0	1.9	0.4	0.3	-1.3	-1.4
Systolic Blood Pressure	0.7	3.4	9.0	3.0	0.2	1.0	1.8
Vitamin and mineral supplements	0.7	1.0	2.6	-0.7	0.0	-1.6	-0.9
Average weekly fortified wine intake	0.7	0.8	3.3	1.8	0.1	0.1	-0.1
Relative age voice broke	0.7	1.0	2.3	-1.1	-0.1	1.5	0.7
Qualifications: CSEs or equivalent	0.7	1.0	2.0	-0.3	-0.7	-1.2	-1.4
Number of full brothers	0.7	0.8	2.5	-0.9	0.0	-1.6	-0.4
Wheeze or whistling in the chest in last year	0.7	1.2	4.3	-0.5	-2.1	-0.3	0.5
Chest pain or discomfort	0.7	1.0	3.2	0.2	-1.8	-0.7	-0.5
Medication: Aspirin	0.7	0.9	1.4	-0.8	-1.2	-0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.2	-0.4	-1.0	-1.1	-1.1
Long-standing illness, disability or infirmity	0.7	1.1	2.7	0.6	-0.4	-1.2	-1.6
Qualifications: nursing, teaching	0.7	1.0	2.0	-0.5	-0.5	-1.3	-1.4
Arm fat-free mass (left)	0.7	3.5	7.5	2.2	-2.7	0.3	1.3
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	-0.3	1.1	1.2	0.8
Triglycerides	0.6	1.0	2.6	-0.7	-1.6	-0.5	0.9
Blood Platelet Count	0.6	6.6	14.1	0.5	3.8	-1.9	-2.9
Neuroticism	0.6	1.4	2.6	1.1	-1.6	-1.2	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	1.1	1.0	-0.6	-0.8
Severe depression (siblings)	0.6	0.6	1.8	-1.4	0.1	0.8	-0.1
High blood pressure	0.6	1.7	4.7	2.2	1.3	-0.1	0.7
Multivitamins +/- minerals	0.6	0.8	1.9	0.9	0.3	1.4	0.5
Allergy	0.6	1.3	3.5	0.7	0.7	-0.9	-1.9
Prospective memory result	0.6	0.7	2.0	0.4	-0.8	-0.4	1.4
Age at first live birth	0.6	1.1	3.7	-0.6	1.9	-0.6	-0.3
Health satisfaction	0.6	0.8	2.9	-1.7	-0.3	-0.0	-0.0
Overall health rating	0.6	1.3	3.0	0.3	-0.3	-1.7	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	0.1	1.5	-0.4	-0.3
Medication: Bendroflumethiazide	0.6	0.9	1.6	-1.1	1.2	-0.3	0.7
Unable to work because of sickness or disability	0.6	0.8	1.5	-0.3	-0.9	-0.8	-1.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	-0.2	0.1	-1.4	-1.1
Heart disease (siblings)	0.6	0.8	1.4	-1.2	-0.2	-1.0	-0.8
Bipolar Disorder (2018)	0.5	0.8	2.6	0.8	-1.6	0.4	0.2
Major Depression (MDD)	0.5	0.6	1.4	0.5	0.9	0.3	-1.2
Neuroticism (2016)	0.5	0.7	1.8	-0.4	-1.3	-0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	1.6	-1.1	0.3	0.2
Pack years adult smoking proportion	0.5	0.8	1.8	1.0	-1.3	-0.4	-0.6
Impedance of leg (right)	0.5	2.2	4.7	1.0	1.0	-1.4	-2.2
Nervous feelings	0.5	0.9	2.0	-1.4	0.9	-0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.1	-0.3	1.3	0.8
Heart attack	0.5	0.6	1.6	-0.2	0.2	-1.3	-1.0
Neuroticism score	0.5	1.1	3.0	0.4	-0.6	-1.7	-0.9
Trunk fat-free mass	0.5	2.7	5.9	1.5	-2.4	0.0	1.6
Number of live births	0.5	0.7	1.2	-0.8	1.1	-0.8	0.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.1	-0.9	-1.0	0.3	0.4
Trunk predicted mass	0.5	2.8	6.1	1.6	-2.5	0.1	1.6
Glaucoma (self-reported)	0.5	0.5	1.4	0.5	-0.1	-0.7	-1.2
Birth weight	0.5	1.1	2.9	-1.7	0.1	-0.5	1.1
Pulse wave peak to peak time	0.5	0.6	1.3	1.2	0.9	-0.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-1.2	-0.2	0.4	0.9
Medication: Seretide 50 evohaler	0.5	0.5	1.5	0.3	-0.7	1.2	0.1
Age at last live birth	0.5	0.7	1.5	-1.2	0.4	-0.8	0.5
Family relationship satisfaction	0.5	0.6	0.9	0.8	0.4	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-1.4	-0.0	0.0	0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.7	0.8	-1.0	-0.3
Hypertension (Self-reported)	0.5	1.5	4.2	2.1	0.9	-0.2	0.9
Ever had bowel cancer screening	0.5	0.6	1.1	-1.1	0.7	-0.7	0.1
Medication for cholesterol	0.5	0.8	1.2	-0.9	-0.8	-1.1	-0.7
Irritability	0.5	0.8	2.0	0.6	-1.4	-0.7	-0.7
Alcohol drinker status: Previous	0.5	0.6	1.2	-0.8	-0.5	1.1	0.7
Arm predicted mass (left)	0.5	2.7	5.6	2.0	-2.4	0.2	1.1
Bipolar Disorder or Schizophrenia	0.4	0.9	1.7	1.2	-0.1	-0.6	-1.3
Neuroticism (Nagel 2018)	0.4	0.8	1.2	0.5	-0.8	-1.1	-1.1
Crohns Disease (2017)	0.4	1.0	1.6	1.3	-0.9	-0.5	-1.1
Mean Putamen Volume	0.4	0.4	1.1	0.5	-1.0	0.1	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.6	0.9	0.8	0.1
Blood Eosinophil Count	0.4	2.8	9.1	0.4	3.0	0.3	-1.3
Allergy or Eczema	0.4	1.0	2.7	-1.0	-0.5	0.5	1.6
Relative age of first facial hair	0.4	0.9	3.5	-0.0	0.2	1.9	-0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	0.1	1.2	-0.5	-0.6
Diabetes (mother)	0.4	0.5	1.2	0.2	0.2	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.6	-0.1	0.3	1.2
High blood pressure (mother)	0.4	0.6	1.0	0.2	0.8	1.0	0.7
Alcohol usually taken with meals	0.4	0.7	1.7	-0.6	0.1	1.3	0.9
Had menopause	0.4	0.5	1.2	0.1	1.1	-0.8	-0.3
Had other major operations	0.4	0.5	0.9	-0.4	-0.9	-1.0	0.3
Financial difficulties in last 2 years	0.4	0.5	1.5	-1.2	-0.0	-0.6	-0.0
Medication: Simvastatin	0.4	0.6	2.3	-0.4	-0.3	-1.5	-0.1
Worrier / anxious feelings	0.4	0.7	1.5	-0.2	-0.4	-1.0	-1.2
Illnesses of mother	0.4	0.5	0.9	-0.0	0.8	-0.8	-0.9
Exposure to tobacco smoke outside home	0.4	0.5	1.7	0.3	-1.3	-0.6	-0.2
Whole body fat-free mass	0.4	2.3	5.7	1.2	-2.4	0.1	1.4
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.8	0.3	0.1	1.2
Medication: Aspirin	0.4	0.5	1.3	-0.5	-0.7	-0.1	1.1
Whole body water mass	0.4	2.4	5.5	1.2	-2.3	0.3	1.6
Number of self-reported non-cancer illnesses	0.4	0.7	2.0	-0.5	-0.5	-1.4	-0.5
Guilty feelings	0.4	0.6	1.1	-0.8	0.7	0.0	1.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.0	-1.7	-0.7	0.5	-0.2
Pain experienced in last month	0.4	0.7	1.8	0.1	-1.4	-0.4	0.8
Supplements: Calcium	0.4	0.4	0.8	-0.9	0.7	-0.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.6	-0.1	-1.2	-0.6
Pack years of smoking	0.4	0.5	1.1	0.8	-1.0	-0.3	-0.6
Impedance of whole body	0.4	2.0	4.3	-0.4	1.6	-1.0	-2.1
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.3	0.3	-0.8	-0.7
Bipolar Disorder (2011)	0.3	0.3	1.3	-1.1	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	0.8	0.9	-0.2	-0.9	-0.7
Lupus	0.3	0.4	1.2	0.3	0.5	-0.3	1.1
Lung FEV1/FVC ratio	0.3	1.4	2.5	0.6	0.6	1.5	-1.6
Sensitivity / hurt feelings	0.3	0.5	1.6	0.2	-0.6	-1.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.4	-1.3	-0.1	0.2
Systolic blood pressure, automated reading	0.3	0.9	2.4	0.4	0.8	0.5	1.5
Medication for hormone replacement therapy	0.3	0.4	0.7	0.8	0.6	-0.3	-0.6
Hand grip strength (right)	0.3	0.7	1.2	0.6	-1.1	0.1	1.1
Maternal smoking around birth	0.3	0.4	0.9	0.9	-0.0	-0.3	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-1.0	0.3	0.7	0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	-0.1	0.7	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	-1.0	-0.0	0.1	1.1
Supplements: Glucosamine	0.3	0.3	0.4	-0.4	-0.6	0.6	-0.6
Sitting height	0.3	2.0	3.3	1.8	-1.6	-0.9	1.1
Impedance of leg (left)	0.3	1.3	3.1	1.3	0.5	-0.6	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	-0.8	0.3	-0.8	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.1	-0.4	-0.7	-1.2
Qualifications: None of the above	0.3	0.5	1.0	-1.0	-0.4	-1.0	0.2
Pain all over the body in last month	0.3	0.3	0.9	-0.1	0.0	0.4	-1.0
Comparative body size at age 10	0.3	0.9	1.8	0.4	-1.4	0.1	1.3
Neck or shoulder pain in last month	0.3	0.5	1.3	-0.7	0.3	-1.2	-0.4
Comparative height size at age 10	0.3	1.6	5.0	1.1	-0.6	-2.2	-0.1
Supplements: Vitamin C	0.3	0.4	0.7	-0.8	0.1	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.3	1.1	-0.6	0.1	1.0
Leg fat-free mass (right)	0.3	1.5	3.4	0.5	-1.8	0.5	1.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	1.2	0.8	0.0	0.1
Leg predicted mass (right)	0.3	1.5	3.3	0.4	-1.8	0.5	1.4
Basal metabolic rate	0.3	1.9	4.9	1.2	-2.2	0.0	1.2
Risk taking	0.3	0.4	1.3	-1.2	-0.0	-0.1	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	1.6	0.4	-0.1	0.1	-1.3
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.4	-0.0	0.4	-0.9
Schizophrenia (2014)	0.2	0.5	0.9	0.7	-0.5	-0.9	-0.6
Hand grip strength (left)	0.2	0.6	1.6	-0.0	-0.7	0.4	1.3
Number of treatments/medications taken	0.2	0.3	0.7	-0.0	0.6	-0.8	-0.5
Medication: Metformin	0.2	0.2	0.6	0.1	-0.8	-0.5	0.3
Leg fat-free mass (left)	0.2	0.9	2.5	0.4	-1.6	0.0	1.0
Townsend deprivation index at recruitment	0.2	0.3	1.1	-1.1	0.3	0.4	-0.2
Age when periods started (menarche)	0.2	0.5	1.0	0.7	-0.4	1.0	-0.4
Leg predicted mass (left)	0.2	1.0	2.6	0.4	-1.6	0.1	1.1
Trunk fat mass	0.2	0.7	2.6	-0.1	-1.6	-0.6	-0.2
Weight	0.2	1.0	3.1	0.5	-1.8	-0.6	0.6
Arm fat percentage (right)	0.2	1.0	2.4	-1.6	-0.8	-0.7	-0.4
Medication: Lansoprazole	0.2	0.2	0.7	0.9	0.3	0.2	-0.1
Arm fat mass (right)	0.2	0.7	2.2	-0.4	-1.5	-0.4	0.3
Tense / ‘highly strung’	0.2	0.3	0.9	0.2	-0.4	0.2	1.0
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	-0.3	1.3	0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.1	0.6	-0.9	0.3
Gout (self-reported)	0.2	0.3	0.8	-0.9	0.7	-0.1	0.1
Medication: Amlodipine	0.2	0.3	0.7	0.6	0.0	-0.5	0.8
Leg fat percentage (right)	0.2	0.6	1.1	0.3	-0.8	-0.7	-1.1
Number of children fathered	0.2	0.3	0.5	0.2	0.7	-0.7	-0.1
Heart disease (mother)	0.2	0.3	0.9	0.9	-0.3	0.2	-0.0
Whole body fat mass	0.2	0.6	2.2	0.1	-1.5	-0.6	-0.1
Arm fat percentage (left)	0.2	0.8	1.6	-1.3	-1.0	-0.8	-0.4
Loneliness, isolation	0.2	0.2	0.4	-0.3	0.5	-0.6	0.3
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.3	-1.0	0.5	0.4
Medication: Gliclazide	0.2	0.2	0.7	0.1	0.3	-0.8	-0.1
Arm fat mass (left)	0.2	0.6	2.2	-0.1	-1.5	-0.5	-0.0
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	-0.5	-0.8	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.8	-0.3	-0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.2	1.0	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	1.1	-0.1	0.1	0.1
Leg fat percentage (left)	0.2	0.6	1.3	0.5	-1.1	-0.3	-0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.1	-0.2	-0.5	0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.3	-0.9	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	-0.8	-0.4	-0.3	-0.3
Depression (Nagel 2018)	0.1	0.1	0.3	-0.2	0.5	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	-0.5	-0.4	-0.3	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.4	-0.8	0.7	0.1
LDL Cholesterol	0.1	0.2	0.5	-0.7	-0.1	-0.2	0.2
BMI	0.1	0.7	1.9	0.7	-1.4	-0.2	0.4
Height	0.1	1.7	4.2	0.1	-1.6	-2.0	-0.5
Hair Pigment	0.1	2.4	4.2	0.5	2.0	-1.0	-2.0
Tanning	0.1	1.1	2.0	-1.4	-0.8	1.2	0.6
Trunk fat percentage	0.1	0.6	0.9	-0.4	-0.9	-0.8	-0.7
Serious illness, injury or assault to yourself	0.1	0.2	0.3	-0.3	-0.5	0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	-0.1	0.3	0.1
Body mass index (BMI)	0.1	0.4	1.5	0.1	-1.2	0.0	0.4
Waist circumference	0.1	0.2	0.5	-0.7	-0.5	-0.2	0.0
Number of incorrect matches in round	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4
Mouth/teeth dental problems	0.1	0.2	0.6	0.8	-0.5	-0.3	-0.2
Fluid intelligence score	0.1	0.2	0.7	0.1	0.8	0.4	0.0
Hip circumference	0.1	0.4	1.4	0.0	-1.2	-0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	0.5	-0.1	-0.8
Standing height	0.1	1.5	2.4	1.4	-1.6	-1.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.3	-0.4	-0.6
Body fat percentage	0.1	0.4	0.8	-0.4	-0.9	-0.6	-0.4
Qualifications: College or University degree	0.1	0.2	0.5	0.1	-0.7	0.5	0.2
Leg fat mass (right)	0.1	0.5	1.4	0.2	-1.2	-0.5	-0.4
Alcohol intake frequency.	0.1	0.3	1.1	-0.3	1.1	0.0	-0.4
Knee pain experienced in last month	0.1	0.2	0.8	-0.1	-0.3	-0.0	-0.9
Back pain experienced in last month	0.1	0.1	0.3	0.6	-0.3	0.2	-0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.4	0.3	-0.6	-0.4	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	-0.5	0.2	-0.2
Alcohol drinker status: Never	0.1	0.1	0.5	0.2	0.2	-0.2	-0.7
Diastolic blood pressure, automated reading	0.1	0.3	0.4	-0.2	0.7	0.4	0.6
Leg fat mass (left)	0.1	0.5	1.9	0.3	-1.4	-0.3	-0.3
Worry (Nagel 2018)	0.0	0.0	0.1	0.0	-0.3	-0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.5	0.3	-0.0	0.1
Diabetes (self-reported)	0.0	0.1	0.2	-0.0	-0.4	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	-0.1	0.3	-0.1	0.2

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