Hub : Genes

KDR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.5270 0.0640 5.6e-17 0.201 NA 0.267 NA 0.229 4.8e-15 NA 4.2e-20 NA 4.2e-17
2 TCGA Glioblastoma Multiforme 0.3310 0.1100 3.0e-03 0.005 0.121 0.056 NA 0.001 2.3e-01 0.00017 8.4e-03 NA 2.8e-01
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0534 0.0253 2.1e-03 0.037 0.014 0.031 NA 0.001 4.8e-05 0.01000 1.8e-04 NA 2.2e-01
4 TCGA Prostate Adenocarcinoma 0.0494 0.0222 5.0e-03 0.021 0.008 0.011 NA 0.018 2.6e-03 0.04000 2.4e-02 NA 5.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 2.6 0.8 -1.6 0.4 0.2
Bipolar Disorder or Schizophrenia 0.4 0.9 1.7 1.2 -0.1 -0.6 -1.3
Depressed Affect (Nagel 2018) 1.0 2.1 4.4 0.3 -0.7 -2.1 -1.9
Depression (Nagel 2018) 0.1 0.1 0.3 -0.2 0.5 0.0 -0.4
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.2 -0.5 -0.4 -0.3 -0.5
Neuroticism (Nagel 2018) 0.4 0.8 1.2 0.5 -0.8 -1.1 -1.1
Schizophrenia (2018) 0.8 1.6 3.2 1.0 1.1 -1.0 -1.8
Schizophrenia vs Biploar Disorder 1.6 2.1 3.7 -0.5 1.9 -1.7 -1.2
Worry (Nagel 2018) 0.0 0.0 0.1 0.0 -0.3 -0.0 0.0
Alzheimer’s Disease (in mother) 0.8 0.9 3.1 -0.4 -1.8 -0.6 0.0
Alzheimer’s Disease (in father) 0.3 0.3 0.7 0.3 0.3 -0.8 -0.7
Alzheimer’s Disease (including proxy) 0.7 1.0 1.9 -0.5 -1.4 -1.0 -0.9
Crohns Disease (2017) 0.4 1.0 1.6 1.3 -0.9 -0.5 -1.1
Irritable Bowel Disease (IBD) 0.2 0.4 1.6 0.4 -0.1 0.1 -1.3
Ulcerative Colitis (UC) 0.2 0.3 0.8 -0.4 -0.0 0.4 -0.9
Major Depression (MDD) 0.5 0.6 1.4 0.5 0.9 0.3 -1.2
Reaction Time 1.1 2.1 3.0 -1.7 1.3 -1.4 -1.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 -0.4 -0.8 0.7 0.1
Breast Cancer 1.4 3.5 8.2 1.5 -2.9 1.7 0.7
Ovarian Cancer 1.0 1.3 3.2 0.2 -1.4 1.8 0.3
Prostate Cancer 1.1 1.5 4.9 2.2 -0.9 -0.6 -0.3
Age at First Birth 0.9 1.4 3.0 0.2 -0.7 1.4 1.7
Bipolar Disorder (2011) 0.3 0.3 1.3 -1.1 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 4.6 -0.8 -0.1 0.4 2.1
Coronary Artery Disease (CAD) 0.8 1.0 3.7 0.5 1.9 0.0 0.0
Crohns Disease (2012) 0.3 0.5 0.8 0.9 -0.2 -0.9 -0.7
Mean Putamen Volume 0.4 0.4 1.1 0.5 -1.0 0.1 0.6
Fasting Glucose 2.4 2.8 4.6 1.4 -1.1 -1.9 -2.1
HbA1C 1.3 1.5 3.1 -1.8 -0.4 0.5 1.5
HDL Cholesterol 0.8 1.4 4.9 2.2 0.2 0.7 -0.1
LDL Cholesterol 0.1 0.2 0.5 -0.7 -0.1 -0.2 0.2
Lupus 0.3 0.4 1.2 0.3 0.5 -0.3 1.1
Neuroticism (2016) 0.5 0.7 1.8 -0.4 -1.3 -0.9 -0.2
Primary Biliary Cirrhosis 0.9 1.3 3.9 -1.1 2.0 -0.4 -0.2
Rheumatoid Arthritis 0.7 0.9 2.1 0.1 0.1 1.2 1.5
Schizophrenia (2014) 0.2 0.5 0.9 0.7 -0.5 -0.9 -0.6
Triglycerides 0.6 1.0 2.6 -0.7 -1.6 -0.5 0.9
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 0.6 0.9 0.8 0.1
Ulcerative Colitis 0.7 1.0 1.9 0.4 0.3 -1.3 -1.4
Blood Eosinophil Count 0.4 2.8 9.1 0.4 3.0 0.3 -1.3
Blood Platelet Count 0.6 6.6 14.1 0.5 3.8 -1.9 -2.9
Blood Red Count 1.0 10.0 27.0 5.2 -2.7 -1.6 -1.8
Blood White Count 1.2 9.0 20.5 -1.4 1.6 -3.3 -4.5
Heel T-Score 1.1 9.0 34.0 -1.1 -5.8 -0.7 0.6
BMI 0.1 0.7 1.9 0.7 -1.4 -0.2 0.4
Height 0.1 1.7 4.2 0.1 -1.6 -2.0 -0.5
Waist Hip Ratio (WHR) 0.0 0.1 0.2 -0.5 0.3 -0.0 0.1
Systolic Blood Pressure 0.7 3.4 9.0 3.0 0.2 1.0 1.8
Smoking Status 1.3 3.1 9.0 -3.0 1.0 -1.5 -0.2
Allergy or Eczema 0.4 1.0 2.7 -1.0 -0.5 0.5 1.6
Cardiovascular Disease 0.8 2.5 8.8 3.0 -0.4 0.8 0.7
Hypothyroidism (self reported) 0.9 2.1 4.0 -2.0 -1.3 -0.9 -1.3
Respiratory disease 1.1 2.4 4.0 1.5 -2.0 1.4 1.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.4 1.6 -1.1 0.3 0.2
Lung FEV1/FVC ratio 0.3 1.4 2.5 0.6 0.6 1.5 -1.6
Lung FVC 4.9 25.2 36.4 -4.0 3.6 -6.0 -6.0
Neuroticism 0.6 1.4 2.6 1.1 -1.6 -1.2 -0.6
Chronotype (morning person) 1.4 3.3 9.6 1.5 -0.1 1.1 3.1
Hair Pigment 0.1 2.4 4.2 0.5 2.0 -1.0 -2.0
Tanning 0.1 1.1 2.0 -1.4 -0.8 1.2 0.6
Hand grip strength (left) 0.2 0.6 1.6 -0.0 -0.7 0.4 1.3
Number of treatments/medications taken 0.2 0.3 0.7 -0.0 0.6 -0.8 -0.5
Average weekly spirits intake 0.8 0.9 2.6 -0.5 1.0 -0.0 -1.6
Sensitivity / hurt feelings 0.3 0.5 1.6 0.2 -0.6 -1.3 -0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.3 1.1 1.0 -0.6 -0.8
Hearing difficulty/problems: Yes 1.1 1.6 4.6 -2.1 1.2 0.0 -0.7
Relative age of first facial hair 0.4 0.9 3.5 -0.0 0.2 1.9 -0.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.6 -0.4 -1.3 -0.1 0.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.5 0.1 1.2 -0.5 -0.6
Ever had hysterectomy (womb removed) 1.0 1.2 3.3 0.3 -1.8 -1.1 0.4
Systolic blood pressure, automated reading 0.3 0.9 2.4 0.4 0.8 0.5 1.5
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 -0.3 1.2 1.4 0.9
Angina 1.3 1.7 3.8 -0.0 -1.0 -1.9 -1.4
Medication for hormone replacement therapy 0.3 0.4 0.7 0.8 0.6 -0.3 -0.6
Vitamin and mineral supplements 0.7 1.0 2.6 -0.7 0.0 -1.6 -0.9
Supplements: Zinc 2.4 2.6 6.9 -2.6 0.9 1.5 0.7
Medication: Co-codamol 1.0 1.1 2.5 -1.3 0.6 -1.6 0.0
Medication: Metformin 0.2 0.2 0.6 0.1 -0.8 -0.5 0.3
Diabetes (father) 1.2 1.5 4.3 1.1 0.6 2.1 0.3
Diabetes (mother) 0.4 0.5 1.2 0.2 0.2 -0.9 -1.1
Severe depression (siblings) 0.6 0.6 1.8 -1.4 0.1 0.8 -0.1
Pack years adult smoking proportion 0.5 0.8 1.8 1.0 -1.3 -0.4 -0.6
Impedance of leg (right) 0.5 2.2 4.7 1.0 1.0 -1.4 -2.2
Leg fat-free mass (left) 0.2 0.9 2.5 0.4 -1.6 0.0 1.0
Trunk fat percentage 0.1 0.6 0.9 -0.4 -0.9 -0.8 -0.7
Hand grip strength (right) 0.3 0.7 1.2 0.6 -1.1 0.1 1.1
Townsend deprivation index at recruitment 0.2 0.3 1.1 -1.1 0.3 0.4 -0.2
Current tobacco smoking 0.9 1.5 2.4 -1.5 0.3 -1.2 -1.4
Average weekly fortified wine intake 0.7 0.8 3.3 1.8 0.1 0.1 -0.1
Maternal smoking around birth 0.3 0.4 0.9 0.9 -0.0 -0.3 -0.8
Fed-up feelings 1.9 3.5 7.0 -0.7 -0.1 -2.6 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.9 -1.0 0.3 0.7 0.1
Relative age voice broke 0.7 1.0 2.3 -1.1 -0.1 1.5 0.7
Taking other prescription medications 0.9 1.3 3.1 0.2 0.1 -1.5 -1.8
Age when periods started (menarche) 0.2 0.5 1.0 0.7 -0.4 1.0 -0.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 0.6 -0.1 0.3 1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 13.1 -1.2 -3.6 -0.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.9 -0.1 0.7 -0.1
Qualifications: CSEs or equivalent 0.7 1.0 2.0 -0.3 -0.7 -1.2 -1.4
Serious illness, injury or assault to yourself 0.1 0.2 0.3 -0.3 -0.5 0.4 -0.2
High blood pressure 0.6 1.7 4.7 2.2 1.3 -0.1 0.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.3 -1.0 -0.0 0.1 1.1
Multivitamins +/- minerals 0.6 0.8 1.9 0.9 0.3 1.4 0.5
Stomach or abdominal pain in last month 1.3 1.6 4.4 -2.1 -0.5 -1.3 0.0
Supplements: Glucosamine 0.3 0.3 0.4 -0.4 -0.6 0.6 -0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.4 0.6 -0.1 0.3 0.1
Medication: Atenolol 1.3 1.6 4.1 0.9 0.5 -2.0 -1.2
Medication: Levothyroxine sodium 3.9 6.5 11.2 -2.5 1.0 -3.3 -2.7
Sitting height 0.3 2.0 3.3 1.8 -1.6 -0.9 1.1
Chronic bronchitis/emphysema (father) 1.2 1.4 4.4 -2.1 -1.1 0.0 0.4
High blood pressure (mother) 0.4 0.6 1.0 0.2 0.8 1.0 0.7
Body mass index (BMI) 0.1 0.4 1.5 0.1 -1.2 0.0 0.4
Impedance of leg (left) 0.3 1.3 3.1 1.3 0.5 -0.6 -1.8
Leg predicted mass (left) 0.2 1.0 2.6 0.4 -1.6 0.1 1.1
Trunk fat mass 0.2 0.7 2.6 -0.1 -1.6 -0.6 -0.2
Waist circumference 0.1 0.2 0.5 -0.7 -0.5 -0.2 0.0
Number of incorrect matches in round 0.1 0.1 0.2 -0.3 -0.3 0.3 0.4
Past tobacco smoking 1.6 3.0 5.7 2.2 -0.8 2.4 0.8
Alcohol usually taken with meals 0.4 0.7 1.7 -0.6 0.1 1.3 0.9
Nervous feelings 0.5 0.9 2.0 -1.4 0.9 -0.5 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.7 -0.8 0.3 -0.8 -0.6
Hearing difficulty/problems with background noise 0.3 0.5 1.4 0.1 -0.4 -0.7 -1.2
Hair/balding pattern: Pattern 2 2.3 2.9 7.3 1.7 -2.7 -0.0 1.1
Had menopause 0.4 0.5 1.2 0.1 1.1 -0.8 -0.3
Had other major operations 0.4 0.5 0.9 -0.4 -0.9 -1.0 0.3
Forced vital capacity (FVC) 2.9 11.2 21.0 -1.6 2.0 -4.6 -4.1
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 10.6 -1.5 -3.2 -0.2 -0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 0.1 -0.3 1.3 0.8
Qualifications: None of the above 0.3 0.5 1.0 -1.0 -0.4 -1.0 0.2
Financial difficulties in last 2 years 0.4 0.5 1.5 -1.2 -0.0 -0.6 -0.0
Mouth/teeth dental problems 0.1 0.2 0.6 0.8 -0.5 -0.3 -0.2
Heart attack 0.5 0.6 1.6 -0.2 0.2 -1.3 -1.0
Allergy 0.6 1.3 3.5 0.7 0.7 -0.9 -1.9
Pain all over the body in last month 0.3 0.3 0.9 -0.1 0.0 0.4 -1.0
Diabetes (self-reported) 0.0 0.1 0.2 -0.0 -0.4 0.2 -0.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.4 -1.1 1.6 0.9 0.1
Medication: Ramipril 1.4 1.8 6.8 2.6 -0.4 0.0 0.4
Medication: Simvastatin 0.4 0.6 2.3 -0.4 -0.3 -1.5 -0.1
Fluid intelligence score 0.1 0.2 0.7 0.1 0.8 0.4 0.0
Illnesses of siblings 1.5 2.1 4.8 2.2 1.0 1.6 0.2
Neuroticism score 0.5 1.1 3.0 0.4 -0.6 -1.7 -0.9
Weight 0.2 1.0 3.1 0.5 -1.8 -0.6 0.6
Impedance of arm (right) 0.9 4.3 5.8 -2.4 2.3 -1.5 -2.0
Arm fat percentage (right) 0.2 1.0 2.4 -1.6 -0.8 -0.7 -0.4
Trunk fat-free mass 0.5 2.7 5.9 1.5 -2.4 0.0 1.6
Hip circumference 0.1 0.4 1.4 0.0 -1.2 -0.5 -0.2
Time employed in main current job 1.6 1.9 4.7 0.2 2.2 -1.2 -1.2
Alcohol intake versus 10 years previously 1.5 2.3 3.9 1.2 -0.6 -2.0 -1.8
Father’s age at death 1.4 1.9 5.4 -2.3 0.9 -0.3 1.1
Worrier / anxious feelings 0.4 0.7 1.5 -0.2 -0.4 -1.0 -1.2
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.3 5.2 1.8 -0.6 -2.1 -2.3
Falls in the last year 0.8 1.1 2.0 -1.4 1.3 0.9 0.2
Hair/balding pattern: Pattern 3 3.5 5.3 8.4 -1.8 2.5 -1.8 -2.9
Number of live births 0.5 0.7 1.2 -0.8 1.1 -0.8 0.5
Forced expiratory volume in 1-second (FEV1) 2.4 8.0 16.9 -0.9 1.9 -3.2 -4.1
Pulse rate 1.3 2.2 4.7 -1.1 2.2 0.0 -1.7
Happiness 1.0 1.2 4.3 0.1 0.5 2.1 0.6
Noisy workplace 0.9 1.1 4.4 -2.1 0.2 -0.4 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.6 0.1 0.5 -0.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.2 1.8 -0.8 1.1 0.7
Mouth/teeth dental problems: Dentures 2.0 3.4 8.1 -1.5 2.8 1.8 -0.3
Asthma 1.9 3.8 6.3 0.2 -1.7 2.5 2.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.3 1.0 -1.8 0.4 0.8
Medication: Cholesterol lowering 1.4 2.2 5.7 0.0 -1.5 -2.4 -1.0
Depression (self-reported) 0.9 1.0 2.9 1.7 -0.4 0.1 -1.0
Medication: Lansoprazole 0.2 0.2 0.7 0.9 0.3 0.2 -0.1
Prospective memory result 0.6 0.7 2.0 0.4 -0.8 -0.4 1.4
Lung cancer (father) 1.4 1.6 4.0 -0.9 2.0 1.3 0.1
Illnesses of mother 0.4 0.5 0.9 -0.0 0.8 -0.8 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 12.9 -1.3 2.1 -2.7 -3.6
Pulse wave Arterial Stiffness index 0.5 0.5 1.1 -0.9 -1.0 0.3 0.4
Impedance of arm (left) 0.8 3.5 4.2 -1.9 1.9 -1.7 -2.0
Arm fat mass (right) 0.2 0.7 2.2 -0.4 -1.5 -0.4 0.3
Trunk predicted mass 0.5 2.8 6.1 1.6 -2.5 0.1 1.6
Standing height 0.1 1.5 2.4 1.4 -1.6 -1.1 0.6
Length of working week for main job 0.8 0.9 1.7 0.9 -0.1 1.3 1.0
Exposure to tobacco smoke at home 1.0 1.1 2.7 1.3 -1.6 -0.3 0.1
Breastfed as a baby 2.4 2.9 7.5 -0.4 -1.9 -2.7 -0.7
Tense / ‘highly strung’ 0.2 0.3 0.9 0.2 -0.4 0.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.5 0.3 -0.4 -0.6
Hair/balding pattern: Pattern 4 0.2 0.6 1.8 -0.3 1.3 0.7 0.1
Birth weight of first child 0.8 1.4 4.7 -0.3 -0.8 -2.2 0.5
Peak expiratory flow (PEF) 1.3 3.0 7.9 1.2 0.9 -1.3 -2.8
Pulse wave reflection index 1.1 1.4 2.7 -1.0 -1.6 0.8 1.1
Ever highly irritable/argumentative for 2 days 1.0 1.2 1.9 -0.5 1.4 -1.4 -0.8
Loud music exposure frequency 1.2 1.3 4.2 0.0 -2.0 -0.9 0.4
Qualifications: O levels/GCSEs or equivalent 1.2 1.8 3.0 1.3 -0.7 1.5 1.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.9 0.1 0.6 -0.9 0.3
Blood clot in the leg (DVT) 0.9 1.1 2.7 -0.7 0.3 -1.6 -1.2
Medication: Paracetamol 1.1 1.9 4.4 -1.4 -0.4 1.0 2.1
Headache pain in last month 1.8 3.0 6.3 -2.5 2.1 -0.6 -0.9
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 5.4 -0.8 0.9 2.3 1.0
Glaucoma (self-reported) 0.5 0.5 1.4 0.5 -0.1 -0.7 -1.2
Gout (self-reported) 0.2 0.3 0.8 -0.9 0.7 -0.1 0.1
Hypothyroidism/myxoedema (self-reported) 2.3 4.6 7.3 -2.1 0.2 -2.7 -2.5
Medication: Amlodipine 0.2 0.3 0.7 0.6 0.0 -0.5 0.8
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.7 1.6 -1.4 0.2 -1.0
Birth weight 0.5 1.1 2.9 -1.7 0.1 -0.5 1.1
Chronic bronchitis/emphysema (mother) 1.4 1.6 3.0 -0.7 -0.7 -1.5 -1.7
High blood pressure (siblings) 1.1 1.5 3.0 -1.2 -0.8 -1.7 -1.0
Forced vital capacity (FVC), Best measure 2.7 9.8 17.5 -1.7 2.3 -4.2 -3.6
Body fat percentage 0.1 0.4 0.8 -0.4 -0.9 -0.6 -0.4
Leg fat percentage (right) 0.2 0.6 1.1 0.3 -0.8 -0.7 -1.1
Arm fat-free mass (right) 0.8 4.0 8.3 2.3 -2.9 0.4 1.4
Exposure to tobacco smoke outside home 0.4 0.5 1.7 0.3 -1.3 -0.6 -0.2
Comparative body size at age 10 0.3 0.9 1.8 0.4 -1.4 0.1 1.3
Number of full brothers 0.7 0.8 2.5 -0.9 0.0 -1.6 -0.4
Worry too long after embarrassment 0.8 1.4 2.1 1.5 1.2 -0.8 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.0 -0.9 -0.6 -1.1 -1.4
Wheeze or whistling in the chest in last year 0.7 1.2 4.3 -0.5 -2.1 -0.3 0.5
Number of children fathered 0.2 0.3 0.5 0.2 0.7 -0.7 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 5.1 -0.4 -2.2 -0.2 0.3
Age at first live birth 0.6 1.1 3.7 -0.6 1.9 -0.6 -0.3
Pulse wave peak to peak time 0.5 0.6 1.3 1.2 0.9 -0.4 -0.3
Health satisfaction 0.6 0.8 2.9 -1.7 -0.3 -0.0 -0.0
Shortness of breath walking on level ground 1.0 1.1 2.2 -0.8 -0.4 -1.5 -1.3
Qualifications: College or University degree 0.1 0.2 0.5 0.1 -0.7 0.5 0.2
Eye problems/disorders: None of the above 2.1 2.4 4.8 -2.2 1.7 -0.5 -1.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.5 -1.2 -0.2 0.4 0.9
Emphysema/chronic bronchitis 1.5 1.6 3.3 0.4 -1.8 1.7 -0.2
Medication for pain relief, constipation, heartburn 0.8 1.4 3.3 0.9 1.3 0.1 -1.8
Neck or shoulder pain in last month 0.3 0.5 1.3 -0.7 0.3 -1.2 -0.4
Medication: Blood pressure 1.7 3.0 8.1 1.4 -1.0 -2.8 -1.1
Angina (self-reported) 1.0 1.3 3.1 -0.1 -0.9 -1.8 -1.2
Migraine (self-reported) 3.4 4.2 7.2 -2.0 1.0 -2.7 -2.1
Medication: Ibuprofen 1.9 2.3 2.9 1.6 -1.5 1.7 1.0
Medication: Allopurinol 1.8 2.4 6.0 -1.8 2.4 -0.6 -0.6
Medication: Omeprazole 0.8 1.0 2.0 -1.4 0.0 -1.1 -0.8
Medication: Seretide 50 evohaler 0.5 0.5 1.5 0.3 -0.7 1.2 0.1
Mean time to correctly identify matches 1.3 2.5 5.1 -2.2 1.4 -1.1 -1.3
Heart disease (mother) 0.2 0.3 0.9 0.9 -0.3 0.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.6 -0.8 -1.0 1.3 1.9
Whole body fat mass 0.2 0.6 2.2 0.1 -1.5 -0.6 -0.1
Leg fat mass (right) 0.1 0.5 1.4 0.2 -1.2 -0.5 -0.4
Arm predicted mass (right) 0.9 4.5 9.5 2.5 -3.1 0.6 1.5
Pulse rate, automated reading 0.9 2.8 7.7 -0.5 2.8 -0.2 -1.8
Alcohol intake frequency. 0.1 0.3 1.1 -0.3 1.1 0.0 -0.4
Comparative height size at age 10 0.3 1.6 5.0 1.1 -0.6 -2.2 -0.1
Number of full sisters 1.0 1.2 2.4 -1.6 0.7 -0.2 -1.4
Suffer from ‘nerves’ 0.8 1.2 2.9 0.2 -0.7 1.2 1.7
Overall health rating 0.6 1.3 3.0 0.3 -0.3 -1.7 -1.4
Chest pain or discomfort 0.7 1.0 3.2 0.2 -1.8 -0.7 -0.5
Had major operations 4.1 4.9 17.8 0.6 -4.2 -0.5 1.0
Age at last live birth 0.5 0.7 1.5 -1.2 0.4 -0.8 0.5
Family relationship satisfaction 0.5 0.6 0.9 0.8 0.4 1.0 0.9
Leg pain on walking 1.4 1.8 3.8 1.1 -1.1 2.0 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.9 -1.4 -0.0 0.0 0.8
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.8 -0.1 -1.9 -0.0 0.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 -0.7 0.8 -1.0 -0.3
Medication: Aspirin 0.7 0.9 1.4 -0.8 -1.2 -0.3 1.1
Supplements: Vitamin C 0.3 0.4 0.7 -0.8 0.1 0.8 0.5
Knee pain experienced in last month 0.1 0.2 0.8 -0.1 -0.3 -0.0 -0.9
Hypertension (Self-reported) 0.5 1.5 4.2 2.1 0.9 -0.2 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.2 -0.4 -1.0 -1.1 -1.1
Illnesses of father: Heart disease 1.7 2.3 6.8 2.6 -1.1 -0.2 -1.1
Illnesses of siblings: Diabetes 1.7 2.1 6.4 -2.5 -0.1 -1.1 -0.7
Smoking status: Previous 1.2 1.8 3.8 -2.0 1.1 -1.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.3 1.1 -0.6 0.1 1.0
Whole body fat-free mass 0.4 2.3 5.7 1.2 -2.4 0.1 1.4
Leg fat-free mass (right) 0.3 1.5 3.4 0.5 -1.8 0.5 1.4
Arm fat percentage (left) 0.2 0.8 1.6 -1.3 -1.0 -0.8 -0.4
Average weekly red wine intake 1.3 2.0 7.6 0.5 -2.8 -0.0 0.2
Handedness (chirality/laterality): Left-handed 1.3 1.6 4.7 -1.0 2.2 -0.2 -0.7
Mood swings 1.0 1.8 4.4 0.5 -0.3 -2.1 -1.6
Loneliness, isolation 0.2 0.2 0.4 -0.3 0.5 -0.6 0.3
Long-standing illness, disability or infirmity 0.7 1.1 2.7 0.6 -0.4 -1.2 -1.6
Ever had bowel cancer screening 0.5 0.6 1.1 -1.1 0.7 -0.7 0.1
Diabetes diagnosed by doctor 0.2 0.4 1.0 0.3 -1.0 0.5 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.2 0.1 1.5 -0.4 -0.3
Friendships satisfaction 1.1 1.4 2.5 -0.5 1.1 -1.6 -1.2
Qualifications: nursing, teaching 0.7 1.0 2.0 -0.5 -0.5 -1.3 -1.4
Commuting to job workplace: Walk 2.3 2.5 3.7 -1.9 -0.5 -1.9 -1.5
Eye problems/disorders: Cataract 1.5 1.8 2.8 1.3 -1.6 0.4 1.7
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.4 1.2 0.8 0.0 0.1
Medication for cholesterol 0.5 0.8 1.2 -0.9 -0.8 -1.1 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.9 4.6 9.0 1.7 0.8 -2.4 -3.0
Back pain experienced in last month 0.1 0.1 0.3 0.6 -0.3 0.2 -0.1
Mineral and other dietary supplements 1.1 1.4 2.5 0.4 1.1 -1.6 -1.4
Breast cancer (self-reported) 1.2 1.5 2.2 1.4 -0.7 -1.1 -1.5
Asthma (self-reported) 1.9 3.7 6.0 0.1 -1.8 2.4 2.4
Osteoporosis (self-reported) 0.4 0.5 1.4 -0.8 0.3 0.1 1.2
Osteoarthritis (self-reported) 1.5 2.0 5.3 -0.7 -0.7 -1.3 -2.3
Medication: Aspirin 0.4 0.5 1.3 -0.5 -0.7 -0.1 1.1
Medication: Gliclazide 0.2 0.2 0.7 0.1 0.3 -0.8 -0.1
Illnesses of father: None of the above (group 1) 1.0 1.3 2.4 -1.5 1.4 -0.9 -0.2
Smoking status: Current 1.0 1.5 2.4 -1.6 0.6 -1.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.1 8.7 -1.3 2.3 -0.7 -2.9
Whole body water mass 0.4 2.4 5.5 1.2 -2.3 0.3 1.6
Leg predicted mass (right) 0.3 1.5 3.3 0.4 -1.8 0.5 1.4
Arm fat mass (left) 0.2 0.6 2.2 -0.1 -1.5 -0.5 -0.0
Number of self-reported non-cancer illnesses 0.4 0.7 2.0 -0.5 -0.5 -1.4 -0.5
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.2 0.2 -0.1 -0.5
Miserableness 2.0 3.4 7.3 0.4 -0.1 -2.7 -2.5
Guilty feelings 0.4 0.6 1.1 -0.8 0.7 0.0 1.1
Wears glasses or contact lenses 1.2 1.4 2.8 -1.7 0.2 -1.4 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.6 -0.2 -0.5 -0.8 -0.1
Hearing aid user 3.0 3.4 7.4 0.3 -0.3 2.7 2.4
Mother’s age at death 0.9 1.1 2.2 -0.3 0.9 -1.1 -1.5
Financial situation satisfaction 1.8 2.3 3.6 -1.9 1.9 0.4 -1.4
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 -0.1 0.3 -0.1 0.2
Commuting to job workplace: Public transport 1.4 1.7 3.5 0.4 1.1 -1.3 -1.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.6 0.8 -0.3 -0.1 -0.1
Medication: Blood pressure 1.1 2.1 3.3 0.5 1.6 1.8 1.5
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.9 0.2 1.0 0.3 0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.1 1.1 -0.1 0.1 0.1
High cholesterol (Self-reported) 0.1 0.2 0.4 0.3 -0.6 -0.4 0.1
Medication: Bendroflumethiazide 0.6 0.9 1.6 -1.1 1.2 -0.3 0.7
Medication: Paracetamol 1.7 2.6 6.9 -1.3 -0.4 1.3 2.6
Medication: Lisinopril 1.1 1.4 2.9 0.4 -1.0 -1.7 -1.2
Medication: Atorvastatin 4.1 5.1 7.2 2.2 1.1 -2.7 -2.6
Illnesses of father: High blood pressure 0.1 0.1 0.3 0.5 -0.5 0.2 -0.2
Alcohol drinker status: Never 0.1 0.1 0.5 0.2 0.2 -0.2 -0.7
Ever smoked 1.5 2.6 6.5 -1.5 0.0 -2.5 -1.2
Basal metabolic rate 0.3 1.9 4.9 1.2 -2.2 0.0 1.2
Leg fat percentage (left) 0.2 0.6 1.3 0.5 -1.1 -0.3 -0.9
Arm fat-free mass (left) 0.7 3.5 7.5 2.2 -2.7 0.3 1.3
Number of operations (self-reported) 1.3 1.9 5.7 0.6 -2.4 -0.9 0.8
Average weekly beer plus cider intake 0.9 1.3 3.9 0.2 1.2 -0.3 -2.0
Irritability 0.5 0.8 2.0 0.6 -1.4 -0.7 -0.7
Risk taking 0.3 0.4 1.3 -1.2 -0.0 -0.1 0.7
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.1 -0.2 -0.5 0.8
Fractured/broken bones in last 5 years 0.2 0.2 0.7 -0.3 -0.9 0.1 0.1
Age started oral contraceptive pill 0.8 1.1 1.9 -1.4 -0.4 1.1 0.9
Diastolic blood pressure, automated reading 0.1 0.3 0.4 -0.2 0.7 0.4 0.6
Ever depressed for a whole week 0.8 1.0 2.2 -0.4 -1.5 0.8 1.0
Unable to work because of sickness or disability 0.6 0.8 1.5 -0.3 -0.9 -0.8 -1.2
Commuting to job workplace: Cycle 0.9 1.0 1.4 1.2 -0.9 1.1 0.9
Myopia 1.9 2.7 4.0 -1.5 1.0 -1.9 -2.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 3.0 -1.7 -0.7 0.5 -0.2
Cholesterol lowering medication 1.2 1.8 4.6 0.4 2.1 -0.8 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.7 -0.8 -0.4 -0.3 -0.3
Pain experienced in last month 0.4 0.7 1.8 0.1 -1.4 -0.4 0.8
Supplements: Calcium 0.4 0.4 0.8 -0.9 0.7 -0.1 -0.6
Basal cell carcinoma (self-reported) 0.7 0.9 1.5 -0.3 1.1 1.2 0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.9 -0.2 0.1 -1.4 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.4 -0.6 -0.1 -1.2 -0.6
Heart disease (siblings) 0.6 0.8 1.4 -1.2 -0.2 -1.0 -0.8
Alcohol drinker status: Previous 0.5 0.6 1.2 -0.8 -0.5 1.1 0.7
Pack years of smoking 0.4 0.5 1.1 0.8 -1.0 -0.3 -0.6
Impedance of whole body 0.4 2.0 4.3 -0.4 1.6 -1.0 -2.1
Leg fat mass (left) 0.1 0.5 1.9 0.3 -1.4 -0.3 -0.3
Arm predicted mass (left) 0.5 2.7 5.6 2.0 -2.4 0.2 1.1