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chr4:76,163,816-78,026,629

Best TWAS P=5.63e-30 · Best GWAS P=5.42e-43 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC158	0.16	0.09	lasso	3	0.08	4.1e-04	10.4	-11.4	5.6e-30	-0.75	0.05	0.57	TRUE
24	GTEx	Thyroid	FAM47E	0.28	0.22	lasso	5	0.24	5.8e-18	7.5	-7.8	9.4e-15	-0.53	1.00	0.00	TRUE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STBD1	0.09	0.04	blup	81	0.09	7.5e-10	-4.2	7.7	2.0e-14	0.53	0.19	0.81	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	STBD1	0.12	0.04	blup	81	0.09	1.4e-10	-0.8	6.7	2.7e-11	0.29	0.03	0.97	TRUE
2	GTEx	Brain Cerebellar Hemisphere	FAM47E	0.29	0.17	lasso	4	0.19	1.2e-05	-4.0	-6.4	2.0e-10	-0.39	0.34	0.05	TRUE
11	GTEx	Liver	FAM47E	0.30	0.08	lasso	8	0.12	3.1e-04	-4.0	-6.1	1.4e-09	-0.38	0.13	0.14	TRUE
22	GTEx	Testis	FAM47E-STBD1	0.38	0.36	lasso	6	0.33	1.9e-15	-6.0	-5.8	8.2e-09	-0.37	1.00	0.00	TRUE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM47E	0.15	0.09	blup	95	0.15	7.5e-16	-4.6	-5.2	1.8e-07	-0.32	1.00	0.00	TRUE
9	GTEx	Esophagus Mucosa	FAM47E-STBD1	0.11	0.10	lasso	6	0.09	1.2e-06	10.4	10.4	1.9e-25	0.69	0.86	0.07	FALSE
23	GTEx	Thyroid	FAM47E-STBD1	0.13	0.11	lasso	4	0.09	2.0e-07	10.3	10.3	4.3e-25	0.67	0.99	0.01	FALSE
10	GTEx	Esophagus Muscularis	FAM47E-STBD1	0.11	0.06	lasso	2	0.08	1.6e-05	-7.8	9.8	1.1e-22	0.59	0.74	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC158	0.26	0.15	lasso	6	0.20	1.8e-24	-7.2	-9.8	1.4e-22	-0.60	1.00	0.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	CCDC158	0.13	0.10	lasso	4	0.13	2.1e-16	-7.2	-9.1	7.3e-20	-0.55	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	FAM47E-STBD1	0.09	0.04	lasso	3	0.04	5.9e-04	-7.9	9.0	2.0e-19	0.52	0.60	0.04	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	STBD1	0.07	0.03	blup	82	0.04	3.5e-04	10.4	8.4	3.0e-17	0.58	0.00	0.99	FALSE
6	GTEx	Brain Putamen basal ganglia	FAM47E	0.28	0.16	lasso	8	0.13	6.3e-04	7.5	-8.4	6.0e-17	-0.55	0.17	0.26	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC158	0.10	0.02	enet	12	0.06	1.1e-06	-7.3	-8.2	1.8e-16	-0.45	0.24	0.57	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC158	0.10	0.04	blup	79	0.04	1.4e-04	-7.2	-8.2	2.2e-16	-0.52	0.77	0.14	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC158	0.08	0.05	blup	80	0.06	1.5e-07	-7.2	-8.2	2.7e-16	-0.54	0.29	0.66	FALSE
16	GTEx	Pituitary	FAM47E	0.50	0.38	lasso	10	0.34	3.3e-09	7.6	-8.1	6.7e-16	-0.57	0.70	0.27	FALSE
12	GTEx	Lung	FAM47E	0.25	0.09	lasso	3	0.09	2.3e-07	7.5	-8.0	1.1e-15	-0.61	0.67	0.33	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM47E	0.14	0.15	enet	11	0.14	1.9e-08	7.6	-7.9	2.5e-15	-0.50	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM47E	0.06	0.07	lasso	6	0.07	1.5e-14	7.5	-7.9	3.7e-15	-0.53	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STBD1	0.07	0.05	lasso	5	0.04	1.7e-05	-7.9	7.8	8.3e-15	0.44	0.45	0.47	FALSE
20	GTEx	Stomach	FAM47E-STBD1	0.13	0.04	lasso	2	0.04	4.6e-03	-7.9	7.7	1.0e-14	0.41	0.26	0.16	FALSE
13	GTEx	Nerve Tibial	FAM47E-STBD1	0.10	0.03	enet	19	0.06	3.4e-05	10.3	7.7	1.8e-14	0.46	0.51	0.38	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FAM47E	0.03	0.04	lasso	3	0.02	8.7e-04	7.5	-7.6	3.1e-14	-0.54	0.33	0.50	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	FAM47E	0.16	0.03	lasso	1	0.02	2.0e-02	7.6	-7.6	3.6e-14	-0.53	0.21	0.10	FALSE
21	GTEx	Stomach	FAM47E	0.39	0.18	lasso	10	0.20	8.9e-10	7.5	-7.5	5.0e-14	-0.49	1.00	0.00	FALSE
17	GTEx	Prostate	FAM47E	0.32	0.29	lasso	7	0.29	6.5e-08	7.4	-7.5	5.5e-14	-0.54	0.76	0.04	FALSE
14	GTEx	Nerve Tibial	FAM47E	0.14	0.14	lasso	3	0.12	9.1e-09	7.6	-7.5	8.3e-14	-0.52	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	FAM47E	0.18	0.14	enet	9	0.13	1.1e-04	7.4	-7.4	9.8e-14	-0.50	0.25	0.06	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM47E	0.11	0.11	lasso	1	0.09	2.4e-04	7.4	-7.4	1.1e-13	-0.53	0.50	0.24	FALSE
15	GTEx	Pancreas	FAM47E	0.37	0.27	lasso	7	0.27	6.7e-12	7.5	-7.2	5.1e-13	-0.52	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	FAM47E	0.22	0.19	lasso	8	0.20	2.0e-19	7.5	-7.2	6.5e-13	-0.46	1.00	0.00	FALSE
7	GTEx	Breast Mammary Tissue (Female)	FAM47E	0.35	0.03	lasso	7	0.09	1.3e-03	-4.0	-7.1	1.5e-12	-0.39	0.11	0.28	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	STBD1	0.05	0.01	blup	81	0.02	3.2e-03	-1.9	6.9	6.8e-12	0.47	0.01	0.79	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM47E	0.25	0.26	lasso	8	0.30	4.2e-35	7.5	-6.8	1.0e-11	-0.41	1.00	0.00	FALSE
19	GTEx	Skin Sun Exposed Lower leg	FAM47E	0.14	0.07	lasso	5	0.08	3.0e-07	7.6	-6.6	3.8e-11	-0.39	0.99	0.00	FALSE
5	GTEx	Brain Hippocampus	FAM47E	0.33	0.25	enet	6	0.25	1.2e-06	-4.6	-6.6	3.9e-11	-0.30	0.21	0.08	FALSE
4	GTEx	Brain Cortex	FAM47E	0.36	0.13	lasso	8	0.13	2.0e-04	7.5	-6.4	1.3e-10	-0.39	0.30	0.11	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM47E	0.07	0.06	lasso	4	0.07	2.2e-08	7.4	-6.4	1.9e-10	-0.38	1.00	0.00	FALSE
3	GTEx	Brain Cerebellum	FAM47E	0.25	0.17	lasso	7	0.17	9.2e-06	-4.0	-6.1	1.0e-09	-0.37	0.31	0.20	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	STBD1	0.04	0.00	blup	81	0.02	4.3e-03	10.4	5.9	4.2e-09	0.39	0.00	0.82	FALSE
26	YFS	Blood	SDAD1	0.02	0.00	blup	467	0.02	1.5e-06	-1.6	5.7	9.8e-09	0.39	0.52	0.36	FALSE