TWAS hub - CCDC158

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2620	0.0430	0.0e+00	0.147	0.180	0.187	0.178	0.205	1.9e-17	2.0e-21	3.0e-22	4.2e-21	1.9e-24
2	ROSMAP	Brain Pre-frontal Cortex	0.1296	0.0303	6.0e-12	0.099	0.104	0.111	0.116	0.130	1.2e-12	3.2e-13	4.1e-14	1.0e-14	2.1e-16
3	TCGA	Brain Lower Grade Glioma	0.0847	0.0334	1.2e-06	0.046	0.062	0.059	NA	0.042	4.9e-06	1.5e-07	3.0e-07	NA	1.3e-05
4	TCGA	Pancreatic Adenocarcinoma	0.1640	0.0820	2.0e-03	0.086	0.066	0.038	NA	0.076	1.8e-04	1.0e-03	1.0e-02	NA	4.1e-04
5	TCGA	Prostate Adenocarcinoma	0.1032	0.0460	8.3e-06	0.018	0.051	0.058	NA	0.039	5.2e-03	4.2e-06	1.1e-06	NA	5.5e-05
6	TCGA	Thyroid Carcinoma	0.1020	0.0430	1.4e-06	0.037	0.037	0.008	NA	0.033	1.6e-04	1.4e-04	4.6e-02	NA	3.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	8.8	85.2	130.0	-9.8	-9.1	-8.2	-11.4	-8.2	-8.2
Illnesses of father: Heart disease	8.8	12.2	17.5	4.2	3.9	2.8	4.0	2.4	3.3
Illnesses of father: None of the above (group 1)	5.6	6.9	10.4	-3.2	-3.1	-1.3	-2.7	-2.4	-2.6
Length of working week for main job	5.4	6.0	8.3	2.6	2.7	1.5	2.6	2.9	2.2
Alzheimer’s Disease (including proxy)	4.6	6.7	9.1	2.6	2.4	2.5	2.7	2.1	3.0
Systolic Blood Pressure	4.4	21.9	28.8	5.3	5.4	4.7	4.7	2.7	4.8
Systolic blood pressure, automated reading	3.9	11.3	16.5	3.9	4.1	3.0	3.3	2.4	3.3
Medication: Lansoprazole	3.9	4.4	7.4	1.9	1.9	1.9	2.1	2.7	2.1
Other serious medical condition/disability diagnosed by doctor	3.8	4.9	7.2	-2.6	-2.5	-2.7	-1.7	-1.3	-2.2
Number of full sisters	3.7	4.5	6.1	2.1	2.0	1.7	2.2	2.5	2.2
Alcohol intake versus 10 years previously	3.6	5.4	7.0	-2.6	-2.4	-1.9	-2.4	-2.0	-2.5
HbA1C	3.4	3.8	7.2	1.9	1.6	2.0	2.7	1.7	1.6
Smoking Status	3.4	8.2	10.3	3.1	3.2	2.6	3.2	2.3	2.6
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	5.0	-2.0	-2.2	-2.2	-1.6	-2.2	-1.9
Medication for hormone replacement therapy	3.3	3.6	5.9	-2.2	-2.4	-1.8	-1.2	-1.7	-1.9
Lung FVC	3.1	15.7	18.1	4.1	4.1	4.0	4.3	3.3	3.9
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	4.2	2.0	2.0	1.1	1.6	2.1	1.9
Alcohol intake frequency.	3.0	6.9	10.2	-3.2	-3.2	-2.1	-2.6	-2.0	-2.5
Illnesses of mother	2.9	3.6	9.6	-2.0	-1.7	-1.7	-3.1	-1.2	-0.9
Happiness	2.6	3.1	4.9	1.5	1.8	2.2	0.8	1.9	2.0
Worrier / anxious feelings	2.5	4.7	5.7	2.4	2.4	1.8	1.9	2.3	2.2
Medication: Omeprazole	2.5	3.0	5.5	-1.4	-1.8	-1.8	-1.0	-2.3	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	5.8	2.4	2.4	2.4	2.1	2.0	2.4
Forced vital capacity (FVC), Best measure	2.4	8.9	11.8	3.4	3.4	3.1	3.0	1.6	3.0
Ever had hysterectomy (womb removed)	2.3	2.6	4.3	2.1	1.9	1.6	2.0	0.4	1.1
Forced vital capacity (FVC)	2.3	9.0	11.0	3.3	3.2	3.2	3.3	2.1	2.8
Pulse wave Arterial Stiffness index	2.3	2.7	7.7	-1.4	-1.1	-1.1	-1.6	-2.8	-1.1
Pulse wave peak to peak time	2.3	2.7	7.6	1.4	1.0	1.2	1.9	2.8	1.1
Schizophrenia (2018)	2.2	4.5	6.3	-2.5	-2.4	-1.4	-2.3	-2.5	-1.3
Fasting Glucose	2.2	2.6	4.7	-1.3	-1.7	-1.9	-0.6	-2.2	-1.5
Cardiovascular Disease	2.2	7.3	13.5	3.0	2.9	1.7	3.7	2.3	2.2
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.2	2.2	2.3	1.4	1.7	0.1	1.4
Blood clot in the leg (DVT)	2.1	2.7	5.2	2.1	2.3	1.4	1.6	-0.0	1.3
Emphysema/chronic bronchitis	2.1	2.3	2.6	1.5	1.4	1.6	1.6	1.4	1.6
Heart disease (mother)	2.1	2.6	4.7	1.8	1.7	1.5	2.2	1.0	1.3
Illnesses of father: High blood pressure	2.1	2.6	3.5	1.9	1.8	1.3	1.7	1.2	1.7
Schizophrenia (2014)	2.0	4.3	6.5	-2.2	-2.2	-1.4	-2.4	-2.6	-1.5
Alcohol usually taken with meals	2.0	3.2	5.0	-1.8	-2.2	-2.1	-0.9	-1.1	-2.0
Father’s age at death	2.0	2.7	4.4	-1.8	-2.0	-1.6	-1.0	-1.2	-2.1
Miserableness	2.0	3.5	6.1	1.8	2.0	2.5	1.8	1.4	1.5
Neuroticism	1.9	4.6	5.7	2.3	2.4	2.2	2.1	2.0	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.2	-1.5	-1.2	-1.2	-2.1	-1.6	-1.2
Medication: Atorvastatin	1.9	2.3	3.5	1.8	1.9	1.0	1.3	1.4	1.5
Alcohol drinker status: Never	1.9	2.3	4.2	-1.5	-1.2	-0.9	-2.1	-1.8	-1.3
Hearing difficulty/problems with background noise	1.8	2.9	3.8	2.0	1.9	1.8	1.8	1.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.0	1.2	1.3	2.0	1.1	1.3	1.6
Wears glasses or contact lenses	1.8	2.0	3.5	-1.5	-1.7	-1.9	-0.9	-0.7	-1.4
Ovarian Cancer	1.7	2.3	4.0	-1.6	-1.9	-2.0	-0.7	-0.7	-1.7
Past tobacco smoking	1.7	3.2	5.5	-1.9	-1.7	-1.3	-2.4	-1.7	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	7.4	2.7	2.6	2.6	2.4	0.9	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	2.8	1.5	1.0	0.9	1.7	1.7	1.5
Ever smoked	1.7	3.0	6.3	2.0	1.7	0.9	2.5	1.3	1.5
Average weekly beer plus cider intake	1.7	2.4	5.1	1.6	1.9	2.3	0.9	0.6	1.4
Vascular/heart problems diagnosed by doctor	1.7	4.5	7.2	-2.6	-2.6	-0.9	-2.7	-1.3	-1.9
Alzheimer’s Disease (in mother)	1.6	1.9	2.9	1.3	1.1	1.2	1.7	1.2	1.7
Lung FEV1/FVC ratio	1.6	8.1	8.8	-2.9	-3.0	-2.8	-2.9	-2.9	-2.6
Mouth/teeth dental problems	1.6	2.5	3.3	-1.4	-1.6	-1.8	-1.1	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	7.3	2.6	2.4	2.6	2.7	1.1	2.1
Medication: Cholesterol lowering	1.6	2.5	4.0	1.8	1.6	1.4	2.0	0.9	1.6
Supplements: Calcium	1.6	1.8	2.9	-1.1	-1.2	-1.5	-0.8	-1.7	-1.6
Bipolar Disorder or Schizophrenia	1.5	3.6	4.6	-2.1	-2.0	-1.5	-1.9	-2.1	-1.5
Hair/balding pattern: Pattern 2	1.5	2.0	3.8	1.5	1.9	1.1	0.4	1.2	1.7
Mouth/teeth dental problems: Dentures	1.5	2.5	3.4	1.7	1.8	1.3	1.3	1.4	1.8
Loud music exposure frequency	1.5	1.7	3.4	-1.1	-0.8	-0.8	-1.9	-1.6	-1.3
Smoking status: Previous	1.5	2.2	3.6	1.4	1.2	1.3	1.7	1.9	1.3
Medication for cholesterol	1.5	2.3	3.5	1.5	1.6	1.8	1.1	1.3	1.9
Current tobacco smoking	1.4	2.3	4.2	1.8	1.8	1.0	2.0	0.4	1.3
High blood pressure (siblings)	1.4	2.0	3.3	1.5	1.5	0.9	1.0	1.6	1.8
Eye problems/disorders: Cataract	1.4	1.7	2.8	-1.3	-1.5	-1.7	-1.1	-0.6	-1.4
Breast cancer (self-reported)	1.4	1.7	4.4	-1.4	-1.2	-0.9	-2.1	-0.9	-0.9
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.1	-1.0	-1.2	-1.8	-0.2	-0.9	-1.6
Eye problems/disorders: None of the above	1.3	1.5	2.0	-1.1	-1.0	-1.1	-1.4	-1.4	-1.2
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.1	-0.9	-1.4	-1.5	-0.7	-1.2
Triglycerides	1.2	2.0	3.9	-1.3	-1.4	-2.0	-1.1	-1.2	-1.2
Qualifications: CSEs or equivalent	1.2	1.6	3.5	1.2	1.2	0.7	1.3	1.9	1.1
Multivitamins +/- minerals	1.2	1.6	3.0	1.4	1.3	1.0	1.1	0.8	1.7
Hair/balding pattern: Pattern 3	1.2	1.7	3.4	-1.0	-1.4	-1.0	-0.5	-1.9	-1.6
Neck or shoulder pain in last month	1.2	1.8	2.3	-1.5	-1.3	-1.3	-1.1	-1.4	-1.2
Average weekly champagne plus white wine intake	1.2	1.6	4.1	1.2	0.8	1.3	2.0	1.1	0.7
Diastolic blood pressure, automated reading	1.2	3.7	6.7	2.4	2.6	1.6	1.7	0.8	1.9
Worry (Nagel 2018)	1.1	2.4	3.4	1.5	1.4	1.3	1.7	1.8	1.5
Hearing difficulty/problems: Yes	1.1	1.6	3.0	1.1	1.4	1.7	0.7	1.3	1.3
Angina	1.1	1.4	2.4	1.3	1.5	0.9	0.8	0.7	1.5
Illnesses of siblings	1.1	1.6	2.4	-1.6	-1.4	-0.6	-1.2	-1.4	-1.2
Comparative height size at age 10	1.1	6.1	7.7	2.7	2.8	2.1	2.5	2.3	2.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.9	1.1	1.0	0.6	1.7	0.3	1.3
Irritability	1.1	1.9	4.6	1.3	1.1	0.5	2.1	1.6	0.9
Alzheimer’s Disease (in father)	1.0	1.0	2.6	0.8	0.8	1.6	0.5	0.9	1.1
Medication: Co-codamol	1.0	1.1	3.2	-0.5	-0.2	-1.8	-0.9	-1.4	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.6	1.1	1.0	1.5	1.6	-0.2	0.3
High blood pressure	1.0	2.8	6.7	2.1	2.0	0.2	2.6	0.5	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.4	-1.5	-1.4	-1.2	-1.5	-0.7	-1.3
Medication: Gliclazide	1.0	1.2	2.4	1.4	1.0	0.7	1.5	0.7	0.9
Smoking status: Current	1.0	1.5	3.1	1.5	1.5	0.8	1.8	0.2	1.1
Commuting to job workplace: Cycle	1.0	1.2	3.0	-1.2	-1.0	-1.2	-1.7	0.2	-0.5
Crohns Disease (2017)	0.9	2.0	2.8	1.5	1.6	1.3	1.7	1.2	1.2
Crohns Disease (2012)	0.9	1.4	2.0	1.3	1.4	0.9	1.1	1.1	1.3
Heart attack	0.9	1.1	3.0	0.8	0.9	-0.1	0.8	1.7	1.3
Pulse wave reflection index	0.9	1.1	2.7	-1.1	-0.8	-0.3	-1.4	-1.6	-0.5
Pain experienced in last month	0.9	1.4	2.6	1.2	1.0	1.6	1.2	1.0	1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.0	0.9	1.0	-0.1	0.8	1.7	1.2
Waist Hip Ratio (WHR)	0.8	3.6	5.1	2.3	1.9	1.9	2.0	1.6	1.6
Taking other prescription medications	0.8	1.3	2.2	-1.1	-1.3	-1.5	-0.2	-1.2	-1.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.7	-1.1	-1.3	-0.8	-0.7	-0.8	-0.9
High blood pressure (mother)	0.8	1.1	2.2	0.6	0.6	1.5	1.3	1.3	0.4
Breastfed as a baby	0.8	1.0	2.5	-0.8	-1.1	-1.6	-0.4	-0.8	-0.7
Knee pain experienced in last month	0.8	1.3	2.0	-1.3	-1.2	-1.4	-1.0	-0.7	-1.1
Hypertension (Self-reported)	0.8	2.3	5.5	1.9	1.8	0.4	2.4	0.3	0.9
Mood swings	0.8	1.4	2.5	0.9	1.1	1.6	0.9	1.4	1.0
Commuting to job workplace: Public transport	0.8	0.9	1.7	-0.9	-1.1	-1.2	-0.6	-0.5	-1.3
Depressed Affect (Nagel 2018)	0.7	1.5	2.3	1.3	1.5	1.3	1.2	0.9	1.0
Schizophrenia vs Biploar Disorder	0.7	1.0	1.8	-1.3	-1.2	-0.5	-1.3	-0.7	-0.4
Prostate Cancer	0.7	1.0	1.2	-1.0	-0.9	-1.1	-1.1	-1.1	-1.0
Medication: Metformin	0.7	0.9	1.7	1.1	0.9	0.4	1.3	1.2	0.5
Fed-up feelings	0.7	1.3	2.4	1.1	1.6	0.9	0.6	1.0	1.3
Medication: Ramipril	0.7	0.9	1.9	1.0	1.1	1.4	0.4	0.2	1.1
Exposure to tobacco smoke at home	0.7	0.8	1.8	-0.7	-0.5	-0.4	-1.0	-1.4	-1.0
Peak expiratory flow (PEF)	0.7	1.7	3.0	1.4	1.3	1.7	1.2	0.6	1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	-1.3	-1.1	0.3	-1.2	-0.3	-0.9
Angina (self-reported)	0.7	0.9	1.6	1.0	1.3	0.6	0.6	0.6	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.1	1.0	0.9	0.4	1.1	1.0	0.8
Neuroticism (Nagel 2018)	0.6	1.4	2.1	1.3	1.3	0.9	1.5	1.1	1.0
Ulcerative Colitis (UC)	0.6	1.1	1.6	-1.2	-1.1	-0.5	-1.0	-1.1	-1.2
Rheumatoid Arthritis	0.6	0.8	1.5	-0.8	-0.7	-0.9	-0.5	-1.2	-1.0
Relative age of first facial hair	0.6	1.2	1.8	1.3	1.3	0.5	0.9	1.1	1.1
Diabetes (father)	0.6	0.8	1.1	1.0	0.9	-0.1	1.0	0.9	1.1
Diabetes (mother)	0.6	0.8	3.2	0.5	0.3	-0.5	0.8	1.8	0.5
Severe depression (siblings)	0.6	0.7	1.9	-0.9	-0.7	-0.7	-1.4	-0.4	-0.6
Medication: Atenolol	0.6	0.7	1.2	-1.1	-1.0	-1.1	-0.9	-0.1	-0.5
Pain all over the body in last month	0.6	0.6	1.2	0.8	1.0	0.4	0.5	1.1	0.7
Neuroticism score	0.6	1.3	1.8	1.2	1.3	1.1	1.4	0.9	0.9
Gout (self-reported)	0.6	0.8	2.0	-0.6	-0.8	-0.6	0.6	-1.4	-1.0
Migraine (self-reported)	0.6	0.7	1.3	-0.9	-1.0	-0.9	-1.1	0.6	-0.2
Leg pain on walking	0.6	0.7	2.3	-0.6	0.0	-0.5	-1.5	-1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	-0.9	-0.8	-0.8	-1.2	-0.6	-0.6
Osteoporosis (self-reported)	0.6	0.7	1.0	-1.0	-0.9	-1.0	-0.6	-0.4	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.7	-0.6	-0.4	-0.8	-1.6	-0.6	-0.6
Leg fat percentage (left)	0.6	2.1	3.9	-0.9	-1.1	-2.0	0.2	-1.6	-1.9
Basal cell carcinoma (self-reported)	0.6	0.7	2.5	0.5	0.1	-0.3	1.6	1.0	0.6
Age at First Birth	0.5	0.7	1.6	-0.7	-0.7	0.5	-1.3	-1.1	-0.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.0	0.9	0.9	0.5	1.4	-0.4	0.1
Hand grip strength (left)	0.5	1.2	3.8	0.8	0.7	0.8	0.8	1.9	1.0
Leg fat-free mass (left)	0.5	2.6	8.8	1.8	1.5	0.5	3.0	0.7	0.6
Trunk fat percentage	0.5	1.9	3.9	-1.1	-1.2	-2.0	-0.6	-1.4	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.5	-0.9	-0.4	-0.4	-1.6	-0.7	-0.4
Relative age voice broke	0.5	0.7	1.4	1.0	1.2	0.3	0.1	0.8	1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.4	0.2	-0.1	0.4	0.9	-1.6	-0.3
Impedance of leg (left)	0.5	2.7	7.5	-1.9	-1.7	-0.2	-2.7	-1.2	-0.9
Leg predicted mass (left)	0.5	2.6	9.0	1.9	1.5	0.5	3.0	0.7	0.6
Had other major operations	0.5	0.6	2.3	-0.4	-0.3	-1.0	-0.3	-1.5	-0.5
Trunk predicted mass	0.5	2.6	9.4	1.7	1.3	0.7	3.1	0.9	0.5
Glaucoma (self-reported)	0.5	0.6	1.4	0.7	0.6	1.0	1.2	0.4	0.1
Body fat percentage	0.5	1.8	4.0	-1.0	-1.1	-2.0	-0.4	-1.4	-1.6
Medication: Seretide 50 evohaler	0.5	0.6	1.9	-0.3	-0.7	-1.4	0.1	-0.9	-0.8
Leg fat-free mass (right)	0.5	2.5	8.5	1.8	1.5	0.5	2.9	0.6	0.5
Leg predicted mass (right)	0.5	2.5	8.6	1.8	1.5	0.5	2.9	0.6	0.5
Number of self-reported non-cancer illnesses	0.5	0.8	2.9	0.8	0.5	0.1	1.7	0.8	0.7
Unable to work because of sickness or disability	0.5	0.7	2.2	-0.6	-0.6	-1.5	-0.1	-0.5	-0.8
Alcohol drinker status: Previous	0.5	0.5	0.9	0.6	0.5	0.4	0.9	1.0	0.7
Pack years of smoking	0.5	0.7	1.2	0.9	1.1	0.5	0.7	0.3	1.1
Coronary Artery Disease (CAD)	0.4	0.4	1.1	0.5	0.4	0.5	0.4	1.1	0.9
LDL Cholesterol	0.4	0.6	0.8	0.8	0.9	0.8	-0.4	0.9	0.9
Primary Biliary Cirrhosis	0.4	0.5	2.1	0.4	0.4	-0.8	0.0	-1.4	-0.3
Height	0.4	7.5	10.5	3.2	3.2	2.4	2.9	2.1	2.5
Vitamin and mineral supplements	0.4	0.6	1.2	-0.7	-0.9	-0.9	0.0	-0.6	-1.1
Hand grip strength (right)	0.4	1.1	2.2	1.0	0.7	0.7	1.3	1.5	0.9
Townsend deprivation index at recruitment	0.4	0.6	1.8	0.6	0.3	-1.1	1.3	-0.0	0.4
Trunk fat-free mass	0.4	2.6	9.3	1.7	1.3	0.6	3.0	0.9	0.5
Falls in the last year	0.4	0.5	1.2	0.9	0.9	0.1	1.1	0.1	0.4
Depression (self-reported)	0.4	0.4	1.0	-0.5	-0.3	-1.0	-1.0	-0.5	0.2
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.5	0.7	-1.0	0.6	-0.9	0.1
Health satisfaction	0.4	0.5	0.7	0.3	0.8	0.8	-0.7	0.7	0.8
Medication: Blood pressure	0.4	0.7	1.7	1.0	0.9	0.4	1.3	-0.1	0.8
Medication: Allopurinol	0.4	0.5	1.4	-0.0	-0.3	-0.3	1.2	-0.9	-0.7
Age at last live birth	0.4	0.6	1.0	0.8	0.7	1.0	0.9	0.5	0.5
Whole body fat-free mass	0.4	2.5	9.1	1.8	1.4	0.5	3.0	0.8	0.5
Whole body water mass	0.4	2.4	8.9	1.7	1.4	0.5	3.0	0.6	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	0.4	0.5	0.2	0.5	1.3	0.9
Medication: Bendroflumethiazide	0.4	0.6	1.0	0.9	1.0	-0.2	1.0	-1.0	-0.4
Medication: Lisinopril	0.4	0.5	1.4	0.6	0.5	0.0	0.6	1.2	0.6
Risk taking	0.4	0.6	1.0	0.9	1.0	0.1	0.4	0.8	1.0
Impedance of whole body	0.4	2.3	8.2	-1.7	-1.4	-0.3	-2.9	-0.6	-0.4
Breast Cancer	0.3	0.8	2.7	0.8	0.7	-0.3	1.6	0.8	0.1
Lupus	0.3	0.4	0.7	0.6	0.7	0.9	0.2	0.0	0.9
Ulcerative Colitis	0.3	0.4	0.6	-0.8	-0.8	-0.3	-0.8	-0.4	-0.5
Allergy or Eczema	0.3	0.7	2.4	-0.2	-0.6	-1.1	-0.0	1.5	0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.0	0.1	-0.4	-0.2	1.4	-0.2	-0.9
Chronotype (morning person)	0.3	0.6	1.0	-0.7	-0.7	-0.6	-0.6	-1.0	-0.9
Average weekly spirits intake	0.3	0.3	0.6	0.8	0.7	0.3	0.6	0.0	0.6
Supplements: Zinc	0.3	0.4	0.6	0.7	0.8	0.4	0.7	0.2	0.7
Pack years adult smoking proportion	0.3	0.4	0.9	0.8	0.9	0.5	0.5	0.0	0.8
Impedance of leg (right)	0.3	1.7	6.1	-1.4	-1.3	0.1	-2.5	-0.4	-0.3
Average weekly fortified wine intake	0.3	0.3	0.6	0.4	0.5	0.7	0.5	0.6	0.8
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.6	0.5	0.4	1.1	0.6	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.5	0.8	-0.4	0.3	0.9	0.3
Allergy	0.3	0.7	2.0	-0.4	-0.3	-0.2	-0.4	-1.4	-1.2
Time employed in main current job	0.3	0.3	0.6	0.7	0.8	0.6	-0.3	0.5	0.4
Noisy workplace	0.3	0.3	1.3	-0.3	-0.5	-0.0	-0.2	-1.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.8	-0.9	-0.7	0.1	0.5	-0.7
Impedance of arm (left)	0.3	1.2	4.8	-1.1	-0.9	-0.1	-2.2	0.3	0.1
Standing height	0.3	2.8	4.0	1.8	1.7	1.8	2.0	1.4	1.5
Birth weight of first child	0.3	0.5	1.2	-0.6	-0.5	-0.8	-1.1	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.2	-0.4	-0.6	-1.1	0.1	-0.4	-0.2
Medication: Amlodipine	0.3	0.4	1.1	0.8	0.6	0.5	1.0	-0.1	0.4
Number of full brothers	0.3	0.4	0.7	-0.6	-0.5	-0.8	-0.1	0.6	-0.7
Mean time to correctly identify matches	0.3	0.6	1.1	-0.8	-0.9	-0.7	-1.0	-0.8	-0.3
Arm predicted mass (right)	0.3	1.4	5.7	1.2	1.0	0.3	2.4	0.2	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.9	0.9	0.4	0.7	-0.4	0.2
Financial situation satisfaction	0.3	0.4	1.4	-0.5	-0.2	0.6	-1.2	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.4	-0.7	-0.7	0.3	-0.6	-0.5
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.3	0.3	0.8	1.0	0.3	-0.2
Basal metabolic rate	0.3	1.9	7.7	1.5	1.1	0.2	2.8	0.5	0.2
Arm fat-free mass (left)	0.3	1.7	6.6	1.4	1.1	0.4	2.6	0.1	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.7	0.8	0.6	0.5	0.7	0.4
Leg fat mass (left)	0.3	1.0	2.0	-0.0	-0.3	-1.4	1.1	-1.0	-1.3
Arm predicted mass (left)	0.3	1.5	6.5	1.3	1.0	0.2	2.5	0.1	-0.0
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.3	-0.3	-0.6	-0.2	-0.7	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	0.8	0.6	0.8	1.2	-0.0	0.4
Major Depression (MDD)	0.2	0.3	0.9	-0.4	-0.1	-0.6	0.0	-1.0	-0.4
Reaction Time	0.2	0.3	0.9	-0.6	-0.6	0.0	-1.0	0.2	0.2
Bipolar Disorder (2011)	0.2	0.2	0.5	0.7	0.7	0.2	0.6	-0.1	0.2
Mean Putamen Volume	0.2	0.2	0.5	-0.5	-0.6	0.2	-0.3	-0.1	-0.7
BMI	0.2	1.2	2.9	0.1	-0.3	-1.5	1.7	-0.7	-1.2
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.6	-0.9	-0.9	0.3	-0.4	-0.3
Respiratory disease	0.2	0.4	1.6	0.2	-0.2	-0.1	1.3	0.8	0.4
Sensitivity / hurt feelings	0.2	0.3	1.0	-0.5	-0.3	-0.3	-0.5	-1.0	-0.6
Maternal smoking around birth	0.2	0.3	0.8	0.7	0.9	0.4	0.4	0.0	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.1	-0.4	-0.1	0.8	-0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	-0.5	-0.7	-0.7	-0.4	1.2	0.4
Sitting height	0.2	1.3	4.5	1.3	1.1	0.2	2.1	-0.1	0.5
Body mass index (BMI)	0.2	0.8	1.9	-0.0	-0.2	-1.4	1.0	-0.8	-1.1
Trunk fat mass	0.2	1.0	2.5	-0.4	-0.6	-1.6	0.4	-1.0	-1.3
Waist circumference	0.2	0.6	2.2	0.7	0.4	-0.6	1.5	-0.0	-0.3
Nervous feelings	0.2	0.4	0.7	0.6	0.6	0.5	0.7	0.8	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	-0.0	0.3	0.2	-0.3	1.0	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.4	-0.6	-0.6	-0.2	-0.8	-0.5
Fluid intelligence score	0.2	0.4	1.5	0.6	0.5	-0.4	1.2	-0.3	-0.4
Weight	0.2	0.8	3.0	0.7	0.5	-0.6	1.7	-0.3	-0.5
Impedance of arm (right)	0.2	0.8	3.4	-0.8	-0.6	0.3	-1.8	0.4	0.2
Arm fat percentage (right)	0.2	0.7	2.1	-0.1	-0.3	-1.5	0.6	-0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.5	0.8	0.4	0.5	0.2	0.9
Prospective memory result	0.2	0.2	0.5	0.1	0.3	0.3	-0.5	0.4	0.7
Lung cancer (father)	0.2	0.2	1.0	-0.1	-0.3	-1.0	0.4	0.4	-0.1
Arm fat mass (right)	0.2	0.8	1.7	0.1	-0.1	-1.3	1.2	-0.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.3	-0.3	-0.4	-1.2	0.2	-0.7	0.0
Birth weight	0.2	0.5	1.0	-0.2	-0.4	-1.0	0.6	-0.8	-0.7
Leg fat percentage (right)	0.2	0.9	2.0	-0.4	-0.6	-1.4	0.5	-0.9	-1.3
Arm fat-free mass (right)	0.2	1.1	5.0	1.1	0.8	0.1	2.2	-0.0	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.4	-0.4	-0.8	-0.7	-0.2	0.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.8	0.0	0.1	-0.5	0.1	-1.3	-0.4
Number of children fathered	0.2	0.2	0.6	-0.5	-0.4	-0.4	-0.8	0.5	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	-0.3	-0.2	-0.9	-0.0	0.0	-0.4
Medication: Ibuprofen	0.2	0.3	0.4	-0.5	-0.6	-0.7	0.1	0.4	-0.5
Whole body fat mass	0.2	0.9	2.5	-0.3	-0.5	-1.6	0.6	-0.9	-1.2
Leg fat mass (right)	0.2	0.7	1.9	0.3	0.1	-1.0	1.4	-0.6	-0.8
Chest pain or discomfort	0.2	0.3	1.2	-0.5	-0.1	-0.4	-1.1	-0.0	0.2
Had major operations	0.2	0.2	0.9	0.3	0.4	1.0	-0.2	-0.1	0.1
Family relationship satisfaction	0.2	0.2	0.9	-0.1	0.3	0.4	-1.0	-0.0	0.5
Medication: Aspirin	0.2	0.2	0.8	0.2	0.1	-0.3	0.9	-0.5	-0.1
Arm fat percentage (left)	0.2	0.8	2.7	-0.3	-0.5	-1.6	0.5	-0.5	-1.2
Long-standing illness, disability or infirmity	0.2	0.3	1.1	-0.4	-0.3	-1.0	0.0	0.3	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.8	0.7	0.5	0.2	0.9	0.6	0.1
Friendships satisfaction	0.2	0.2	1.2	-0.4	-0.1	-0.1	-1.1	0.4	0.1
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.4	0.3	-0.3	0.6	0.6	0.2
Arm fat mass (left)	0.2	0.8	1.8	0.1	-0.2	-1.3	1.1	-0.5	-1.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.4	-0.7	-0.3	0.4	-0.2	-0.7
Medication: Blood pressure	0.2	0.3	0.9	0.7	0.6	-0.2	1.0	0.1	-0.0
Myopia	0.2	0.3	0.8	0.2	0.1	0.2	0.7	-0.9	-0.6
Cholesterol lowering medication	0.2	0.3	0.6	-0.4	-0.3	-0.7	-0.3	0.3	-0.8
Heart disease (siblings)	0.2	0.3	0.9	-0.2	-0.2	-0.9	-0.7	0.6	-0.3
Depression (Nagel 2018)	0.1	0.2	0.5	0.3	0.7	0.5	-0.3	-0.2	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	0.6	0.5	-0.3	1.0	-0.2	0.2
HDL Cholesterol	0.1	0.1	0.3	0.1	0.3	-0.3	-0.3	0.5	0.3
Neuroticism (2016)	0.1	0.1	0.2	0.1	0.2	0.2	0.5	0.1	-0.4
Heel T-Score	0.1	0.4	1.4	0.2	-0.2	0.3	1.2	0.9	-0.1
Number of treatments/medications taken	0.1	0.3	0.6	0.5	0.4	-0.6	0.7	0.5	0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.0	0.3	0.5	-0.6	-0.5	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.4	0.6	0.5	-0.0	0.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.4	-0.5	-0.2
Age when periods started (menarche)	0.1	0.2	0.4	0.3	0.1	0.4	-0.5	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.7	0.7	0.6	0.5	0.3	0.3
Number of incorrect matches in round	0.1	0.2	0.8	-0.2	0.0	0.6	-0.9	-0.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.1	0.2	-0.4	-0.5	-0.3	-0.1
Had menopause	0.1	0.1	0.3	0.2	0.1	-0.4	0.3	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.6	0.5	0.6	0.7	0.5	-0.1
Qualifications: None of the above	0.1	0.3	0.6	0.4	0.7	0.2	-0.2	0.5	0.8
Diabetes (self-reported)	0.1	0.1	0.4	0.2	-0.1	-0.3	0.6	0.1	-0.5
Medication: Simvastatin	0.1	0.2	0.8	0.4	0.2	0.3	0.9	0.3	0.1
Hip circumference	0.1	0.4	0.9	0.3	0.2	-0.8	0.9	-0.5	-0.5
Number of live births	0.1	0.2	0.9	0.2	0.1	-0.1	0.5	-0.9	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.2	-0.2	-0.3	-0.5	-0.7	-0.1
Asthma	0.1	0.2	0.6	0.0	-0.2	-0.3	0.8	0.8	0.4
Tense / ‘highly strung’	0.1	0.2	0.5	0.6	0.4	-0.2	0.7	-0.4	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	-0.7	-0.6	-0.3	-0.7	0.0	-0.5
Headache pain in last month	0.1	0.2	0.8	-0.5	-0.3	-0.1	-0.9	-0.4	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.3	0.1	-0.1	-0.2	1.1	-0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.2	-0.2	-0.7	0.8	0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.2	0.3	-0.7	0.1	-0.2	0.2
Comparative body size at age 10	0.1	0.4	1.0	0.3	0.4	-0.1	0.6	1.0	0.8
Worry too long after embarrassment	0.1	0.2	0.3	0.2	0.1	0.6	0.5	-0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.3	0.2	0.1	0.6	-0.7	-0.2
Age at first live birth	0.1	0.3	1.1	0.5	0.4	1.0	0.1	0.1	0.3
Shortness of breath walking on level ground	0.1	0.1	0.6	-0.1	0.1	-0.1	-0.0	-0.8	0.3
Qualifications: College or University degree	0.1	0.2	0.7	-0.2	-0.5	-0.8	0.5	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.4	0.4	0.8	-0.0	0.1	0.4
Pulse rate, automated reading	0.1	0.5	1.4	0.7	0.7	-0.1	1.2	0.3	-0.5
Suffer from ‘nerves’	0.1	0.1	0.2	-0.3	-0.5	-0.3	0.3	0.2	-0.4
Overall health rating	0.1	0.1	0.3	-0.0	0.5	0.1	-0.5	-0.4	0.2
Supplements: Vitamin C	0.1	0.1	0.2	0.3	0.4	0.3	-0.1	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.4	-0.5	-0.7	0.1	-0.3	-0.7
Average weekly red wine intake	0.1	0.1	0.3	-0.0	-0.2	-0.0	0.3	0.5	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.6	0.6	0.1	0.1	-0.1	0.4
Loneliness, isolation	0.1	0.2	0.3	0.3	0.6	0.4	-0.3	0.2	0.6
Ever had bowel cancer screening	0.1	0.2	0.7	0.4	0.3	-0.2	0.1	-0.8	0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	0.2	0.1	0.4	0.5	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	0.3	0.2	0.0	0.9	0.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.1	0.0	-0.2	0.0	0.3	0.5
Mineral and other dietary supplements	0.1	0.2	0.4	0.5	0.4	0.5	0.6	0.0	0.3
Asthma (self-reported)	0.1	0.3	0.9	0.0	-0.2	-0.3	0.7	0.9	0.4
Medication: Aspirin	0.1	0.2	0.8	0.4	0.3	-0.1	0.9	-0.1	0.1
Hearing aid user	0.1	0.2	0.5	0.3	0.5	-0.1	-0.2	0.1	0.7
Mother’s age at death	0.1	0.2	0.3	-0.1	-0.3	0.4	0.6	0.6	0.3
High cholesterol (Self-reported)	0.1	0.1	0.5	0.2	0.1	-0.0	0.7	0.0	-0.2
Medication: Paracetamol	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.4	-0.4	-0.1
Number of operations (self-reported)	0.1	0.1	0.5	0.1	0.2	-0.1	0.2	-0.7	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.4	-0.5	0.1	-0.4	-0.0	-0.1
Age started oral contraceptive pill	0.1	0.2	0.5	0.1	0.3	0.7	-0.5	0.3	0.4
Ever depressed for a whole week	0.1	0.1	0.2	0.2	0.3	-0.1	0.3	-0.0	0.4
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.0	0.1	0.3	0.2	0.0	-0.1
Blood Eosinophil Count	0.0	0.3	0.7	-0.5	-0.8	-0.6	0.5	-0.4	-0.6
Blood Platelet Count	0.0	0.5	1.0	-0.5	-0.7	0.8	0.2	-0.6	-1.0
Blood White Count	0.0	0.1	0.3	0.2	0.3	0.6	0.1	0.1	-0.0
Hair Pigment	0.0	0.8	2.9	0.8	0.4	-0.3	1.7	-0.9	0.4
Tanning	0.0	0.2	0.6	0.5	0.6	0.2	-0.2	0.1	0.8
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.2	-0.2	0.1	0.1	-0.1	0.0
Supplements: Glucosamine	0.0	0.1	0.1	-0.4	-0.3	-0.1	-0.3	0.1	0.1
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.3	0.3	0.1
Pulse rate	0.0	0.1	0.2	0.1	0.4	-0.3	-0.1	0.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.0	0.1	-0.0
Medication: Paracetamol	0.0	0.1	0.3	0.2	0.5	-0.1	-0.3	0.2	0.2
Back pain experienced in last month	0.0	0.1	0.2	-0.2	0.1	-0.4	-0.4	-0.0	0.0
Guilty feelings	0.0	0.1	0.2	0.4	0.4	-0.0	0.0	0.1	-0.0

Hub : Genes

CCDC158

Models

Trait associations