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chr1:151,055,670-153,103,772

Best TWAS P=5.38e-13 · Best GWAS P=2.06e-14 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FLG	0.75	0.44	enet	31	0.61	3.8e-95	-5.92	-5.9	4.5e-09	-0.07	0.99	0.01	TRUE
2	CommonMind	Brain Pre-frontal Cortex	FLG2	0.68	0.35	bslmm	396	0.44	1.0e-58	-5.92	-5.4	6.2e-08	-0.05	0.99	0.01	FALSE
3	GTEx	Colon Sigmoid	S100A11	0.18	0.13	lasso	3	0.14	1.1e-05	6.55	7.2	5.4e-13	0.55	0.21	0.08	TRUE
4	GTEx	Colon Sigmoid	TDRKH	0.28	0.20	enet	16	0.17	1.2e-06	-3.76	-5.9	3.1e-09	-0.26	0.90	0.04	FALSE
5	METSIM	Adipose	FLG	0.19	0.15	lasso	7	0.15	4.3e-22	-6.01	-5.7	1.5e-08	-0.25	0.98	0.02	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	LINGO4	0.15	0.03	lasso	4	0.05	8.9e-10	7.31	5.4	5.8e-08	0.44	0.00	1.00	TRUE
7	The Cancer Genome Atlas	Colon Adenocarcinoma	LINGO4	0.29	0.07	enet	15	0.07	8.3e-05	7.31	7.2	5.8e-13	0.38	0.00	0.98	TRUE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HRNR	0.04	0.03	lasso	1	0.02	2.9e-03	-6.01	6.0	1.9e-09	0.26	0.01	0.87	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LINGO4	0.22	0.06	enet	13	0.06	3.3e-07	7.31	5.3	1.5e-07	0.46	0.00	1.00	TRUE
10	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HRNR	0.25	0.17	lasso	7	0.17	4.3e-10	-6.01	6.0	1.6e-09	0.25	0.00	1.00	TRUE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMCP	0.26	0.05	enet	13	0.09	1.4e-10	0.27	5.6	2.6e-08	0.03	0.07	0.88	TRUE
12	The Cancer Genome Atlas	Lung Adenocarcinoma	LINGO4	0.20	0.07	lasso	4	0.07	3.7e-08	7.31	6.7	1.8e-11	0.53	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HRNR	0.62	0.11	lasso	7	0.14	1.1e-06	-5.49	5.9	4.8e-09	0.28	0.01	0.99	TRUE
14	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LINGO4	0.32	0.09	lasso	8	0.13	3.3e-06	7.31	6.9	3.9e-12	0.46	0.00	0.99	TRUE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	LINGO4	0.53	0.20	lasso	4	0.23	1.1e-23	7.31	5.7	9.2e-09	0.49	0.00	1.00	TRUE
16	The Cancer Genome Atlas	Soft Tissue Sarcoma	HRNR	0.17	0.10	blup	50	0.10	1.1e-06	-6.01	5.5	3.0e-08	0.32	0.00	0.99	TRUE
17	The Cancer Genome Atlas	Thyroid Carcinoma	LINGO4	0.43	0.15	lasso	7	0.20	2.3e-19	7.31	5.2	1.8e-07	0.44	0.00	1.00	FALSE