Best TWAS P=6.66e-10 · Best GWAS P=5.65e-10 conditioned to 0.0348
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | OLA1 | 0.22 | 0.24 | enet | 22 | 0.25 | 2.8e-30 | 5.1 | 6.2 | 6.7e-10 | 0.80 | 0.48 | 0.52 | TRUE |
2 | GTEx | Skin Sun Exposed Lower leg | RP11-394I13.2 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.0e-01 | 5.7 | -5.9 | 4.2e-09 | -0.79 | 0.01 | 0.91 | FALSE |
3 | METSIM | Adipose | CIR1 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.5e-03 | 4.2 | 5.7 | 1.1e-08 | 0.71 | 0.05 | 0.90 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | OLA1 | 0.11 | 0.07 | lasso | 5 | 0.06 | 1.4e-08 | 5.5 | -6.1 | 1.3e-09 | -0.92 | 0.01 | 0.99 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | GPR155 | 0.21 | 0.16 | lasso | 7 | 0.19 | 1.3e-23 | 4.2 | -5.2 | 2.1e-07 | -0.43 | 0.98 | 0.01 | FALSE |
6 | YFS | Blood | OLA1 | 0.01 | 0.00 | lasso | 2 | 0.00 | 1.5e-01 | 4.9 | 5.2 | 2.0e-07 | 0.67 | 0.10 | 0.10 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | OLA1 | 0.12 | 0.13 | lasso | 2 | 0.09 | 1.4e-03 | 5.3 | 5.3 | 1.4e-07 | 0.53 | 0.13 | 0.42 | FALSE |
8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | OLA1 | 0.13 | 0.10 | lasso | 3 | 0.08 | 1.0e-03 | 6.0 | 6.0 | 1.5e-09 | 0.80 | 0.01 | 0.86 | FALSE |