Hub : Genes

GPR155

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0796	0.0315	1.4e-03	0.042	NA	0.027	NA	0.034	2.9e-04	NA	3.1e-03	NA	9.9e-04
2	GTEx	Muscle Skeletal	0.1436	0.0367	8.0e-09	0.032	NA	0.109	NA	0.091	4.1e-04	NA	7.9e-11	NA	3.2e-09
3	GTEx	Thyroid	0.1650	0.0510	1.7e-07	0.139	NA	0.166	NA	0.169	8.7e-11	NA	9.7e-13	NA	6.1e-13
4	NTR	Blood	0.0328	0.0111	1.3e-05	0.009	0.022	0.025	0.023	0.024	4.5e-04	7.2e-08	1.5e-08	3.8e-08	2.6e-08
5	ROSMAP	Brain Pre-frontal Cortex	0.2124	0.0417	1.4e-15	0.157	0.123	0.178	0.182	0.188	1.1e-19	1.6e-15	2.4e-22	8.5e-23	1.4e-23
6	TCGA	Brain Lower Grade Glioma	0.0522	0.0285	1.3e-03	0.071	0.020	0.055	NA	0.069	1.9e-08	2.2e-03	7.7e-07	NA	2.9e-08
7	TCGA	Prostate Adenocarcinoma	0.1151	0.0496	6.3e-05	0.017	0.029	0.021	NA	0.024	6.5e-03	5.1e-04	2.4e-03	NA	1.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.2	1.9	4.8	-1.4	-0.6	1.9	0.6	-0.0	-2.2	1.6
Bipolar Disorder or Schizophrenia	1.4	3.3	15.8	-1.1	-0.2	1.0	2.1	0.9	-0.0	4.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.7	-0.1	-0.2	0.6	1.3	0.7	-0.1	-0.0
Depression (Nagel 2018)	1.6	2.4	10.1	-1.5	-0.9	1.8	3.2	0.0	0.4	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	6.3	0.2	-0.3	0.9	-0.1	-0.5	-2.5	0.4
Neuroticism (Nagel 2018)	0.4	0.9	3.2	0.3	0.3	-0.2	1.0	1.8	1.2	-0.8
Schizophrenia (2018)	1.7	3.5	14.9	-0.4	0.2	-0.3	2.2	1.2	1.7	3.9
Schizophrenia vs Biploar Disorder	0.8	1.0	3.5	0.2	0.4	-0.4	0.8	1.6	1.9	0.3
Worry (Nagel 2018)	0.3	0.6	2.5	0.4	0.6	-0.5	-0.1	1.6	0.8	-0.5
Alzheimer’s Disease (in mother)	1.8	2.1	4.9	1.7	1.4	-1.5	-0.2	2.2	1.3	1.1
Alzheimer’s Disease (in father)	0.9	1.0	3.6	0.3	-0.2	-0.3	0.7	0.3	1.7	1.9
Alzheimer’s Disease (including proxy)	1.4	2.0	6.5	1.3	0.8	-1.1	-0.2	1.5	1.2	2.6
Crohns Disease (2017)	0.8	1.8	4.9	-1.6	-1.2	2.2	0.5	0.1	-1.8	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.4	-1.1	-0.9	1.8	0.1	-0.3	-1.7	-0.1
Ulcerative Colitis (UC)	0.4	0.7	3.6	-0.2	-0.2	0.8	-0.7	-0.5	-1.9	0.3
Major Depression (MDD)	0.6	0.7	1.9	0.1	1.3	-0.1	-0.3	0.9	0.6	1.4
Reaction Time	5.4	10.4	27.0	-3.4	-4.8	2.7	2.0	-5.2	0.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.8	3.6	0.7	0.4	-0.2	-1.1	-0.0	-1.9	-0.6
Breast Cancer	0.2	0.4	1.3	-0.8	-0.6	0.5	1.1	0.0	0.1	-0.3
Ovarian Cancer	1.4	1.8	3.9	-1.3	-2.0	1.3	1.4	-1.8	-0.7	0.3
Prostate Cancer	1.8	2.6	6.6	-2.2	-1.1	2.6	1.9	-0.4	-1.2	0.4
Age at First Birth	0.5	0.8	1.9	-0.6	0.1	0.4	1.4	1.1	1.2	0.3
Bipolar Disorder (2011)	1.8	1.8	6.6	-0.8	0.9	1.0	-0.1	0.9	-1.5	2.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	-0.9	-0.7	0.1	0.8	-0.8	0.7	0.4
Coronary Artery Disease (CAD)	1.2	1.4	3.2	-0.9	-1.3	1.6	-0.2	-1.1	-1.8	-0.6
Crohns Disease (2012)	0.6	1.0	2.7	-0.7	-0.4	1.1	-1.5	-0.5	-1.6	0.3
Mean Putamen Volume	0.9	1.0	2.6	-1.2	-0.7	1.4	-0.3	-0.8	-1.6	-0.4
Fasting Glucose	0.3	0.3	1.4	0.2	-0.2	-0.2	-1.2	0.2	-0.1	-0.7
HbA1C	2.8	3.1	5.3	-2.2	-2.2	2.3	1.5	-1.5	-1.3	-0.6
HDL Cholesterol	0.4	0.6	1.1	1.0	1.0	-0.6	-1.0	0.7	-0.3	0.5
LDL Cholesterol	0.3	0.5	0.8	0.8	0.9	-0.7	-0.9	0.2	0.5	-0.6
Lupus	0.4	0.7	1.9	0.9	0.3	-1.4	-1.0	0.3	0.7	0.4
Neuroticism (2016)	0.4	0.5	3.2	0.1	0.7	0.0	-0.1	1.8	0.2	-0.0
Primary Biliary Cirrhosis	0.1	0.1	0.5	0.0	-0.3	0.3	-0.7	-0.5	0.1	-0.4
Rheumatoid Arthritis	0.1	0.2	0.6	0.4	-0.2	-0.8	0.0	0.4	0.5	0.3
Schizophrenia (2014)	1.2	2.7	8.0	-0.2	0.6	-0.3	1.9	2.0	1.7	2.8
Triglycerides	2.0	3.3	5.3	-2.2	-1.8	2.3	0.9	-1.8	-2.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.8	-0.3	0.2	0.5	-0.0	-0.3	-0.0	1.7
Ulcerative Colitis	0.1	0.1	0.3	-0.3	-0.0	0.5	-0.4	-0.3	-0.6	0.1
Blood Eosinophil Count	0.4	2.7	9.4	-1.5	-0.9	2.0	0.1	-0.9	-3.1	-1.3
Blood Platelet Count	0.1	1.6	6.1	0.1	-1.4	0.3	0.1	-2.5	-1.1	1.3
Blood Red Count	0.1	1.0	5.3	0.6	0.6	-0.6	-0.2	0.8	2.3	0.5
Blood White Count	0.1	0.6	1.2	-0.6	0.2	0.9	1.1	0.6	0.9	0.7
Heel T-Score	0.3	2.5	4.5	-1.3	-1.8	1.7	1.5	-1.7	-2.1	-0.4
BMI	1.5	8.7	17.8	-3.8	-1.8	4.2	2.4	-2.1	-3.8	1.1
Height	0.5	10.0	17.0	4.1	4.1	-3.0	-3.5	3.7	-0.3	1.3
Waist Hip Ratio (WHR)	0.2	1.0	2.2	0.4	1.5	-0.9	-1.4	0.5	1.2	0.5
Systolic Blood Pressure	2.8	14.0	25.5	-4.1	-4.5	5.0	4.2	-3.2	-2.3	1.8
Smoking Status	2.0	4.8	7.8	2.4	2.3	-2.8	-0.8	1.6	2.4	2.5
Allergy or Eczema	0.5	1.2	4.0	-0.7	-1.0	1.3	0.9	-0.4	-2.0	-0.6
Cardiovascular Disease	4.1	13.5	25.2	-4.4	-4.2	5.0	3.7	-3.2	-2.5	1.4
Hypothyroidism (self reported)	0.3	0.6	1.5	-1.2	-0.7	0.8	1.1	-0.5	0.4	0.5
Respiratory disease	0.3	0.7	2.5	0.8	0.8	-0.2	-0.2	1.0	-0.2	1.6
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.8	-0.1	-1.4	0.4	1.7	-1.5	-1.2	1.1
Lung FEV1/FVC ratio	1.0	5.0	8.8	2.1	2.5	-2.5	-3.0	1.8	2.4	0.7
Lung FVC	1.7	8.7	17.5	-3.5	-4.2	3.3	3.4	-2.1	-0.4	-2.1
Neuroticism	0.3	0.6	1.8	0.1	-0.1	-0.1	1.4	1.3	1.0	0.1
Chronotype (morning person)	1.7	4.0	6.1	2.5	1.8	-2.1	-2.2	1.7	0.9	-2.4
Hair Pigment	0.0	1.1	2.2	0.3	1.1	-1.1	-0.8	0.9	1.1	1.5
Tanning	0.1	1.6	7.2	0.7	0.9	-1.2	0.2	1.0	0.1	-2.7
Hand grip strength (left)	0.9	2.3	11.3	1.4	0.4	-1.4	0.1	1.0	-0.1	-3.4
Number of treatments/medications taken	1.8	3.3	4.7	-1.9	-2.2	2.0	2.1	-1.9	-1.4	0.7
Average weekly spirits intake	1.2	1.4	3.4	1.8	0.9	-1.8	-1.4	0.1	0.7	0.3
Sensitivity / hurt feelings	0.6	1.1	3.5	0.2	0.4	-0.7	0.9	1.9	1.7	-0.3
Frequency of depressed mood in last 2 weeks	1.7	2.3	10.2	-0.7	-0.4	1.0	3.2	0.6	1.3	1.6
Hearing difficulty/problems: Yes	0.2	0.2	1.2	-0.1	-0.0	-0.4	-0.3	-0.1	1.1	0.4
Relative age of first facial hair	0.8	1.7	4.5	-1.1	-1.6	0.9	2.1	-1.5	-0.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	-0.4	-0.7	0.8	1.0	-1.3	-0.9	0.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.1	1.1	2.0	-0.8	-1.5	1.7	-0.7	-0.1
Ever had hysterectomy (womb removed)	1.4	1.6	3.3	-1.8	-1.6	1.4	0.8	-0.9	0.0	-1.4
Systolic blood pressure, automated reading	1.2	3.6	7.0	-1.8	-2.0	2.7	1.1	-1.3	-2.3	1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	1.0	0.5	-1.0	-0.7	0.3	-0.1	0.8
Angina	0.2	0.3	1.0	0.0	-0.0	1.0	0.2	-0.1	-0.7	0.6
Medication for hormone replacement therapy	0.6	0.7	1.2	0.8	1.1	-0.7	-1.1	-0.1	-0.9	-0.5
Vitamin and mineral supplements	0.8	1.1	2.3	-1.2	-0.9	1.2	1.1	-0.1	0.4	-1.5
Supplements: Zinc	0.7	0.7	2.9	-0.9	-0.1	0.4	1.7	0.9	0.5	-0.4
Medication: Co-codamol	0.3	0.4	1.6	-0.4	0.5	0.6	-0.3	0.4	-0.0	1.2
Medication: Metformin	0.7	1.0	2.4	-0.4	-1.6	0.4	1.4	-1.2	-0.5	0.6
Diabetes (father)	1.3	1.6	6.2	-1.1	-0.2	1.7	0.4	0.3	-2.5	0.9
Diabetes (mother)	1.0	1.2	3.5	-1.3	-0.4	1.9	0.9	-0.5	-1.5	-0.0
Severe depression (siblings)	0.4	0.5	1.4	-0.5	-0.6	1.1	1.2	0.1	-0.2	-0.2
Pack years adult smoking proportion	0.3	0.5	1.2	0.8	0.6	-1.1	-0.9	0.5	-0.2	-0.3
Impedance of leg (right)	0.7	3.3	18.1	0.5	0.7	-1.3	-0.2	0.4	4.3	1.5
Leg fat-free mass (left)	0.4	2.0	12.2	-0.2	-0.0	1.2	0.3	-0.2	-3.5	0.3
Trunk fat percentage	0.9	3.4	9.0	-2.4	-1.1	3.0	1.4	-1.1	-0.7	2.0
Hand grip strength (right)	0.4	1.2	4.8	1.2	0.4	-1.0	-0.1	0.7	-0.4	-2.2
Townsend deprivation index at recruitment	0.2	0.3	1.2	-0.0	0.4	-0.1	0.2	0.5	0.7	1.1
Current tobacco smoking	1.5	2.4	3.9	1.7	2.0	-1.8	-1.1	1.0	0.7	2.0
Average weekly fortified wine intake	1.1	1.3	3.2	0.4	1.2	-0.3	-1.3	1.2	-1.8	-1.1
Maternal smoking around birth	0.1	0.2	1.4	0.1	0.1	0.0	1.2	-0.1	0.1	0.2
Fed-up feelings	0.3	0.5	1.3	1.1	0.5	-1.1	0.4	0.6	0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	7.0	-0.5	-0.8	0.6	2.6	-0.5	0.4	1.1
Relative age voice broke	0.7	1.1	3.2	1.2	-0.6	-1.3	0.6	-1.8	-0.7	-0.7
Taking other prescription medications	1.2	1.9	4.2	-1.5	-1.5	1.9	2.0	-1.0	-0.0	0.1
Age when periods started (menarche)	1.0	2.3	5.5	2.3	1.1	-2.3	-1.6	0.4	0.7	1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.6	0.2	-0.1	0.3	-1.2	-0.4	-0.5	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.1	-0.2	0.4	0.4	0.1	0.4	-1.4	1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.0	0.5	-0.1	-0.4	0.7	-0.4	-0.3	1.4
Qualifications: CSEs or equivalent	1.1	1.4	4.8	-0.2	0.3	0.1	0.6	0.8	2.0	2.2
Serious illness, injury or assault to yourself	0.6	0.7	2.2	-0.5	0.1	0.9	1.5	0.1	-0.6	1.1
High blood pressure	3.7	10.5	17.2	-3.8	-3.5	4.2	3.7	-2.4	-2.5	1.8
Hayfever, allergic rhinitis or eczema	0.8	1.6	7.8	-0.6	-0.7	1.2	0.6	-0.4	-2.8	-1.0
Multivitamins +/- minerals	0.8	1.0	1.5	1.2	1.1	-1.2	-0.9	0.5	-0.1	1.2
Stomach or abdominal pain in last month	0.6	0.7	4.6	0.5	0.2	-0.0	0.3	-0.3	-0.1	2.1
Supplements: Glucosamine	0.4	0.5	1.7	0.7	-0.2	-0.7	0.8	-1.3	-0.3	-0.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	5.0	-1.9	-1.0	1.8	2.2	0.2	-0.3	-1.1
Medication: Atenolol	0.4	0.5	0.9	-0.7	-0.9	0.2	0.7	-0.9	0.6	-0.8
Medication: Levothyroxine sodium	1.1	1.8	5.8	-0.7	-0.5	-0.1	1.8	-0.6	1.6	2.4
Sitting height	0.4	2.8	6.6	2.6	1.7	-1.7	-2.3	0.9	-0.6	0.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.4	0.5	1.4	-0.1	-1.2	1.6	-0.4	0.4
High blood pressure (mother)	1.3	1.8	3.4	-1.2	-1.1	1.8	1.2	-0.9	-1.7	-1.1
Body mass index (BMI)	0.9	4.0	8.4	-2.3	-1.3	2.9	1.5	-1.2	-2.4	1.8
Impedance of leg (left)	0.6	3.1	17.1	0.5	0.5	-1.4	-0.1	0.2	4.1	1.4
Leg predicted mass (left)	0.4	2.0	12.2	-0.3	-0.1	1.2	0.3	-0.3	-3.5	0.3
Trunk fat mass	0.6	2.4	6.1	-1.7	-0.5	2.5	1.0	-0.7	-1.3	2.1
Waist circumference	0.9	3.1	7.0	-1.9	-0.5	2.6	0.6	-1.1	-2.3	2.1
Number of incorrect matches in round	0.3	0.6	2.1	-0.5	-0.8	0.3	0.9	0.1	1.4	-0.1
Past tobacco smoking	1.8	3.4	6.4	-2.2	-1.6	2.4	0.9	-1.4	-2.5	-1.2
Alcohol usually taken with meals	0.8	1.2	3.7	0.2	0.8	-0.4	-1.2	0.3	-1.9	-1.6
Nervous feelings	1.1	2.1	8.3	1.0	1.2	-0.5	-0.5	2.9	1.1	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.7	0.7	0.7	-0.4	0.7	1.0	0.5	1.3
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.2	-0.1	-0.3	-1.0	-0.4	1.0	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	0.5	-0.8	0.1	0.9	-1.3	-0.6	1.5
Had menopause	0.4	0.5	1.2	0.5	0.9	-0.6	-1.1	0.7	0.4	-0.5
Had other major operations	0.3	0.3	1.5	0.6	0.4	-0.1	-0.3	-0.1	-1.2	-0.3
Forced vital capacity (FVC)	0.3	1.0	4.5	0.0	-1.1	0.2	2.1	0.0	0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.9	-0.6	0.1	0.9	-0.0	0.3	-2.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.9	-0.7	-0.1	0.6	0.7	0.1	-0.4	1.4
Qualifications: None of the above	0.2	0.5	1.1	0.0	-0.8	-0.6	0.9	-0.0	1.1	-0.7
Financial difficulties in last 2 years	2.0	2.7	6.9	-1.7	-1.6	2.1	2.6	-0.4	-1.2	0.4
Mouth/teeth dental problems	0.1	0.1	0.6	0.1	0.2	-0.4	-0.2	0.1	0.7	-0.2
Heart attack	0.4	0.5	1.5	0.5	0.3	-0.0	-1.0	1.2	-0.0	0.7
Allergy	0.3	0.7	3.8	0.3	0.0	-0.6	-0.3	0.1	1.9	-0.8
Pain all over the body in last month	0.5	0.5	1.9	0.3	0.7	0.0	0.1	1.2	0.1	1.4
Diabetes (self-reported)	0.5	0.8	1.9	0.4	-1.4	0.4	0.8	-1.4	-0.7	0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	5.8	-0.7	-0.3	1.1	-1.0	0.0	-2.4	-1.3
Medication: Ramipril	3.0	3.8	6.9	-2.0	-2.2	2.6	2.3	-1.3	-1.6	1.4
Medication: Simvastatin	1.8	2.6	6.1	-1.7	-1.9	2.5	1.1	-1.7	-1.1	0.3
Fluid intelligence score	0.5	1.1	3.1	1.0	0.6	-0.2	-1.8	0.2	-1.7	-0.4
Illnesses of siblings	2.6	3.7	8.2	2.9	2.0	-2.1	-2.8	1.0	0.0	-0.8
Neuroticism score	0.3	0.7	2.8	-0.4	-0.7	0.4	1.7	0.6	0.8	-0.2
Weight	0.4	2.0	6.7	-0.9	-0.2	1.9	0.6	-0.5	-2.6	1.5
Impedance of arm (right)	0.2	0.9	4.0	-0.2	-0.0	0.3	-0.7	0.3	2.0	-1.3
Arm fat percentage (right)	0.8	3.1	9.6	-2.3	-0.7	3.1	1.0	-0.8	-1.5	1.6
Trunk fat-free mass	0.4	2.3	11.2	1.4	1.2	-0.6	-0.8	0.5	-3.4	0.5
Hip circumference	1.4	6.0	13.4	-2.5	-1.9	3.7	1.6	-1.7	-3.5	1.2
Time employed in main current job	7.6	8.7	12.3	-3.2	-3.5	3.0	1.1	-2.5	-3.5	-3.2
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.3	-0.5	-0.1	0.8	0.2	0.9	0.7
Father’s age at death	0.5	0.7	1.6	0.4	1.1	-0.6	0.4	1.2	1.3	-0.4
Worrier / anxious feelings	0.2	0.3	1.7	-0.2	-0.5	0.1	0.3	0.2	0.3	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.6	-0.0	-0.1	0.3	1.6	0.4	0.3	1.1
Falls in the last year	2.2	2.9	4.2	1.6	2.0	-1.8	0.3	1.7	2.0	1.9
Hair/balding pattern: Pattern 3	1.6	2.3	5.3	0.2	1.8	-0.2	-1.7	2.2	-0.4	-2.3
Number of live births	0.4	0.5	1.3	1.0	-0.4	-1.1	0.2	-0.3	0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	0.5	-0.6	-0.2	1.1	-0.2	0.6	-0.9
Pulse rate	3.5	6.0	10.2	2.0	3.2	-2.4	-1.2	2.6	2.0	3.0
Happiness	1.1	1.3	2.5	1.1	1.2	-0.9	-0.3	1.6	1.5	1.0
Noisy workplace	0.3	0.4	2.2	-0.1	-0.2	-0.3	0.4	-0.2	-0.3	1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.9	-1.2	-0.7	1.7	0.2	-0.8	-2.0	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.0	-0.6	-0.1	0.4	-0.2	-0.4	-1.4	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	0.1	-0.1	0.0	-1.1	-0.1	-1.0	-0.5
Asthma	0.3	0.6	1.4	-0.2	-0.3	0.9	0.7	-0.2	-1.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.3	1.7	1.2	-1.6	-0.2	0.9	0.3	1.8
Medication: Cholesterol lowering	0.8	1.3	3.3	-1.3	-1.4	1.8	0.6	-0.7	-0.9	0.5
Depression (self-reported)	0.2	0.3	1.3	0.0	0.1	1.1	0.3	0.2	-0.6	-0.2
Medication: Lansoprazole	1.3	1.5	3.0	-0.8	-1.2	1.4	1.1	-1.7	-1.5	0.0
Prospective memory result	0.8	1.0	3.6	-0.6	-0.3	0.3	1.9	0.9	1.3	-0.4
Lung cancer (father)	1.0	1.2	5.9	0.5	0.7	-1.0	-0.6	0.4	2.4	0.2
Illnesses of mother	0.3	0.3	0.6	-0.3	-0.5	-0.7	-0.4	-0.7	0.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.2	0.2	-0.5	-0.0	1.1	-0.1	0.3	-0.3
Pulse wave Arterial Stiffness index	0.2	0.2	1.2	-0.2	-0.1	0.0	-0.0	-0.1	0.2	1.1
Impedance of arm (left)	0.2	1.1	3.5	-0.6	-0.4	0.7	-0.2	-0.0	1.9	-1.7
Arm fat mass (right)	0.8	3.2	7.7	-1.9	-0.7	2.8	1.1	-0.9	-2.4	1.6
Trunk predicted mass	0.4	2.4	11.7	1.3	1.2	-0.5	-0.9	0.5	-3.4	0.5
Standing height	0.2	2.2	5.4	2.3	1.8	-1.6	-1.4	1.3	-0.8	-0.6
Length of working week for main job	1.3	1.4	4.2	-0.8	-2.1	0.5	1.4	-1.3	-1.0	-0.1
Exposure to tobacco smoke at home	2.8	3.2	8.1	0.9	1.7	-1.5	0.7	1.4	2.3	2.9
Breastfed as a baby	0.6	0.8	2.7	-0.9	-0.9	0.5	0.6	-1.6	-0.1	-0.7
Tense / ‘highly strung’	0.4	0.7	1.9	0.2	0.3	-0.2	1.2	-0.1	1.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.4	0.6	-0.1	-0.2	0.0	-0.5	-0.9
Hair/balding pattern: Pattern 4	0.3	0.6	2.6	-1.1	-0.1	0.6	1.6	0.0	-0.3	0.5
Birth weight of first child	0.2	0.3	0.6	-0.2	-0.5	-0.4	-0.3	-0.8	0.8	-0.7
Peak expiratory flow (PEF)	0.3	0.7	2.0	0.8	0.0	-1.1	0.4	0.5	0.8	-1.4
Pulse wave reflection index	2.6	3.2	5.4	-1.8	-1.9	2.3	1.7	-1.6	-1.7	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.9	0.7	0.3	-0.6	-0.4	-0.5	0.5	1.4
Loud music exposure frequency	3.0	3.3	10.7	1.6	0.8	-1.8	-0.1	-0.3	2.4	3.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	6.2	0.4	-0.1	0.7	-0.1	0.1	-2.5	-0.8
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.6	-1.8	-1.9	1.8	0.9	-1.1	-0.9	0.1
Blood clot in the leg (DVT)	1.3	1.7	3.7	1.3	1.9	-1.3	-1.0	1.4	1.2	0.6
Medication: Paracetamol	2.4	4.0	6.3	2.5	2.1	-2.1	-1.8	1.5	1.3	2.4
Headache pain in last month	0.9	1.5	3.0	1.6	0.9	-1.7	-0.5	0.2	0.9	1.7
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.5	2.5	1.6	-2.5	-1.6	0.6	0.3	-1.3
Glaucoma (self-reported)	0.3	0.3	0.6	-0.6	-0.2	0.6	0.4	0.7	0.8	0.6
Gout (self-reported)	0.1	0.2	1.2	-0.1	-0.2	0.3	0.2	-0.1	0.0	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	-0.6	-0.4	0.1	1.0	-0.0	0.7	1.1
Medication: Amlodipine	1.6	2.3	4.2	-2.1	-1.7	2.0	1.2	-1.4	-0.9	0.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.3	-0.8	-1.1	0.9	1.8	-0.0	-0.2	1.2
Birth weight	2.2	4.7	9.5	2.4	2.7	-2.4	-3.1	2.1	0.3	-0.3
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.1	1.2	1.4	-1.5	-0.3	1.5	1.9	2.2
High blood pressure (siblings)	2.2	3.2	6.7	-2.6	-2.0	1.9	2.3	-1.3	-1.0	0.2
Forced vital capacity (FVC), Best measure	0.3	1.2	5.3	-0.5	-1.3	0.6	2.3	-0.2	-0.3	-0.8
Body fat percentage	0.7	2.8	7.8	-2.2	-0.7	2.8	1.1	-0.7	-0.5	2.2
Leg fat percentage (right)	0.6	2.0	9.4	-1.2	0.2	1.7	0.5	-0.1	0.3	3.1
Arm fat-free mass (right)	0.3	1.4	7.5	0.8	0.6	-0.3	-0.1	0.0	-2.7	1.2
Exposure to tobacco smoke outside home	0.8	1.1	3.2	1.1	0.5	-1.4	0.2	-0.5	0.9	1.8
Comparative body size at age 10	1.4	3.9	10.7	-3.0	-0.8	3.3	1.4	0.1	-1.6	-1.6
Number of full brothers	1.6	2.0	4.5	-1.8	-1.3	1.9	2.1	-0.8	-0.3	0.4
Worry too long after embarrassment	1.2	2.0	4.1	1.3	1.1	-1.2	-0.2	2.0	2.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	5.8	-0.6	0.1	0.1	1.5	0.1	2.4	1.5
Wheeze or whistling in the chest in last year	0.7	1.2	5.2	0.0	0.7	-0.5	0.3	0.8	1.2	2.3
Number of children fathered	1.1	1.3	3.5	1.9	1.1	-1.6	-1.0	0.4	-0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	4.5	2.1	1.6	-1.9	-0.8	1.9	1.4	-0.1
Age at first live birth	0.8	1.4	2.4	-1.2	-1.0	1.3	0.1	-1.0	-1.5	-1.4
Pulse wave peak to peak time	0.2	0.2	1.4	0.2	0.0	0.1	0.1	0.1	-0.2	-1.2
Health satisfaction	0.3	0.4	1.4	0.1	0.9	0.2	-0.2	1.2	0.5	0.4
Shortness of breath walking on level ground	2.1	2.5	5.9	-1.0	-1.6	1.8	1.2	-1.9	-2.4	0.3
Qualifications: College or University degree	0.2	0.6	2.3	0.5	0.4	0.0	-1.5	0.2	-1.2	-0.4
Eye problems/disorders: None of the above	0.7	0.9	2.1	1.0	0.9	-1.2	-1.4	0.6	0.7	0.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	1.8	0.6	-1.2	-0.8	-0.6	-0.9	0.5
Emphysema/chronic bronchitis	1.6	1.8	9.4	0.5	1.1	-0.5	-0.8	0.8	0.2	3.1
Medication for pain relief, constipation, heartburn	1.8	3.0	4.7	-2.1	-1.6	1.9	1.0	-1.1	-1.9	-2.2
Neck or shoulder pain in last month	0.2	0.3	0.6	0.4	0.2	-0.7	0.2	-0.1	0.7	0.7
Medication: Blood pressure	2.3	4.0	7.5	-2.6	-1.9	2.7	2.4	-1.2	-0.6	1.6
Angina (self-reported)	0.2	0.3	1.1	-0.1	-0.2	1.1	0.4	-0.1	-0.5	0.5
Migraine (self-reported)	0.7	0.9	2.6	-1.1	-1.2	0.9	0.1	-1.6	0.1	0.6
Medication: Ibuprofen	1.0	1.2	4.2	0.9	0.9	-1.1	0.2	0.9	0.6	2.0
Medication: Allopurinol	0.5	0.6	1.3	-0.7	-0.6	1.1	0.6	-0.3	-0.7	-1.1
Medication: Omeprazole	2.2	2.7	8.1	1.0	1.9	-1.2	-0.8	1.8	2.8	0.7
Medication: Seretide 50 evohaler	0.3	0.4	1.7	-0.3	-0.4	-0.1	0.1	-0.5	-0.6	1.3
Mean time to correctly identify matches	3.7	7.1	20.2	-2.7	-3.9	2.1	1.3	-4.5	-0.2	-0.5
Heart disease (mother)	0.1	0.2	0.5	0.1	0.1	0.6	0.7	-0.1	-0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	6.5	1.7	1.1	-1.8	0.2	0.4	2.5	0.8
Whole body fat mass	0.6	2.3	5.9	-1.7	-0.4	2.4	1.0	-0.7	-1.4	2.1
Leg fat mass (right)	0.5	2.1	6.9	-1.4	-0.1	2.0	0.8	-0.4	-1.0	2.6
Arm predicted mass (right)	0.3	1.4	7.7	0.8	0.5	-0.3	-0.2	-0.1	-2.8	0.9
Pulse rate, automated reading	1.2	4.0	6.9	2.2	2.5	-2.6	-1.5	1.6	2.0	1.2
Alcohol intake frequency.	1.3	3.0	7.3	-0.7	-2.5	1.2	-0.2	-2.7	-1.3	-1.9
Comparative height size at age 10	0.0	0.2	1.0	-0.0	-0.2	0.5	1.0	0.1	-0.3	0.4
Number of full sisters	0.3	0.3	1.3	-0.3	-0.7	-0.3	1.1	-0.2	0.3	-0.2
Suffer from ‘nerves’	0.5	0.7	1.5	1.2	0.9	-0.3	-0.8	0.9	-1.1	-0.1
Overall health rating	0.6	1.2	4.8	-0.6	-0.4	0.8	1.5	-0.7	0.1	2.2
Chest pain or discomfort	1.0	1.5	8.0	0.1	0.8	0.4	0.9	0.4	0.8	2.8
Had major operations	0.3	0.3	0.8	-0.4	0.5	0.5	0.6	0.9	-0.6	0.2
Age at last live birth	0.2	0.2	0.4	-0.4	-0.6	0.7	0.0	-0.6	-0.4	-0.4
Family relationship satisfaction	1.0	1.2	2.8	1.0	1.7	-0.6	-0.6	1.6	0.0	1.3
Leg pain on walking	0.6	0.7	1.4	0.1	-0.8	0.4	1.0	-0.9	-1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.4	-0.1	0.5	-0.3	-0.1	-0.2	0.2	1.6
Commuting to job workplace: Car/motor vehicle	1.7	2.0	2.9	-1.4	-1.7	0.8	1.7	-1.6	1.3	1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.1	1.5	0.4	-1.8	-2.0	-0.7	0.2	-0.7
Medication: Aspirin	0.3	0.4	1.1	-0.3	-1.0	0.4	0.4	-0.8	0.8	-0.0
Supplements: Vitamin C	0.4	0.5	0.8	-0.7	-0.9	0.7	0.5	-0.8	-0.5	-0.7
Knee pain experienced in last month	1.0	1.6	2.3	-1.1	-1.1	1.2	1.5	-1.5	-1.5	0.8
Hypertension (Self-reported)	3.2	9.0	13.5	-3.3	-3.3	3.7	3.5	-2.6	-2.4	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.6	-0.3	-0.7	0.2	0.3	-1.9	-0.4	-0.6
Illnesses of father: Heart disease	1.9	2.6	8.3	-1.2	-1.1	1.6	1.2	-0.2	-2.9	-1.9
Illnesses of siblings: Diabetes	1.2	1.5	3.0	-1.7	-0.9	1.4	1.7	-0.4	0.3	1.2
Smoking status: Previous	1.2	1.8	4.3	1.2	1.2	-1.3	-0.4	1.7	2.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	9.3	3.0	3.0	-2.9	-1.5	2.3	1.9	0.6
Whole body fat-free mass	0.3	2.0	12.2	0.8	0.7	0.0	-0.4	0.1	-3.5	0.5
Leg fat-free mass (right)	0.4	2.2	13.3	-0.2	-0.2	1.2	0.4	-0.4	-3.6	0.0
Arm fat percentage (left)	0.8	3.0	9.3	-2.2	-0.7	3.0	1.0	-0.9	-1.5	1.6
Average weekly red wine intake	0.1	0.2	0.8	-0.1	0.1	-0.5	-0.0	-0.1	-0.6	-0.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.5	0.7	-1.4	-0.0	0.2	-2.1	-0.9	-0.8
Mood swings	0.3	0.6	2.3	0.1	-0.9	-0.2	1.5	-0.4	0.5	0.5
Loneliness, isolation	0.6	0.8	2.4	0.4	1.1	-0.0	-0.1	1.6	-0.4	1.2
Long-standing illness, disability or infirmity	0.5	0.8	2.0	-0.4	0.8	1.0	0.5	0.9	-1.4	0.5
Ever had bowel cancer screening	0.7	0.8	2.7	-0.6	-0.6	0.0	0.6	0.5	1.3	-1.6
Diabetes diagnosed by doctor	0.6	1.0	1.8	-0.2	-1.3	0.7	1.2	-1.1	-1.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.4	-1.1	-1.0	1.2	1.1	-0.6	-0.8	0.5
Friendships satisfaction	0.4	0.5	1.1	0.4	0.9	-0.1	-0.7	1.0	-0.6	0.7
Qualifications: nursing, teaching	0.3	0.5	1.7	0.5	1.0	-0.2	-1.3	0.7	-0.3	0.3
Commuting to job workplace: Walk	1.2	1.3	4.8	0.5	1.0	-0.2	-1.5	0.4	-2.2	-0.6
Eye problems/disorders: Cataract	0.5	0.6	2.9	-0.5	-0.1	0.4	0.2	-0.9	-1.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	-0.3	0.2	0.1	1.1	-0.0	1.0	0.6
Medication for cholesterol	2.5	3.8	7.7	1.8	2.5	-2.0	-1.3	2.8	1.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.9	-0.4	0.0	0.6	0.6	-0.4	0.5	1.7
Back pain experienced in last month	2.0	3.0	5.3	2.1	2.3	-1.7	-2.1	1.4	-0.9	0.9
Mineral and other dietary supplements	0.4	0.5	1.7	0.2	0.8	-0.3	-1.3	0.6	0.6	0.2
Breast cancer (self-reported)	0.1	0.1	0.4	0.1	-0.4	0.1	0.6	-0.2	-0.3	-0.6
Asthma (self-reported)	0.5	1.0	2.0	-0.6	-0.7	1.3	1.0	-0.3	-1.4	1.2
Osteoporosis (self-reported)	0.8	1.0	3.6	0.4	0.9	-0.7	0.6	0.7	1.9	1.0
Osteoarthritis (self-reported)	0.2	0.2	1.0	0.5	0.3	-0.2	0.3	0.5	-1.0	0.3
Medication: Aspirin	0.3	0.3	0.7	-0.3	-0.9	0.4	0.4	-0.7	0.5	-0.7
Medication: Gliclazide	2.1	2.4	6.1	-0.5	-2.5	0.8	2.4	-1.8	-0.9	-0.0
Illnesses of father: None of the above (group 1)	0.9	1.1	3.6	-0.2	-0.1	-0.1	0.6	-1.0	1.9	1.7
Smoking status: Current	1.3	2.1	4.1	1.7	1.7	-1.8	-1.0	0.5	0.6	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.8	-1.2	-0.8	0.6	1.3	0.1	0.5	-0.5
Whole body water mass	0.4	2.0	12.8	0.7	0.7	0.1	-0.4	0.1	-3.6	0.3
Leg predicted mass (right)	0.4	2.2	13.6	-0.2	-0.3	1.2	0.4	-0.5	-3.7	0.0
Arm fat mass (left)	0.9	3.6	8.6	-2.2	-0.8	2.9	1.1	-1.1	-2.5	1.5
Number of self-reported non-cancer illnesses	2.8	4.9	9.9	-2.0	-2.5	2.7	1.7	-2.0	-3.1	0.3
Average weekly champagne plus white wine intake	1.1	1.5	3.8	-1.9	-0.6	1.9	-0.6	-1.5	-0.2	-0.6
Miserableness	0.3	0.5	1.3	-0.2	-0.9	0.2	1.2	-1.1	0.0	-0.4
Guilty feelings	0.7	1.0	2.5	-0.8	-1.2	1.1	1.6	-0.2	0.6	-1.0
Wears glasses or contact lenses	0.6	0.7	1.6	0.7	1.3	-0.7	-0.9	1.1	-0.2	0.7
Ever taken oral contraceptive pill	0.7	0.8	2.1	-0.5	-0.4	0.1	1.3	-0.7	0.9	1.4
Hearing aid user	1.0	1.1	4.0	-0.2	1.6	-0.0	-1.0	2.0	-0.3	-0.6
Mother’s age at death	0.2	0.2	0.8	0.2	0.1	-0.6	-0.5	-0.0	0.1	-0.9
Financial situation satisfaction	0.7	0.8	3.1	1.1	0.2	-0.7	0.5	0.2	0.9	1.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	0.6	0.6	-0.4	-1.0	0.8	-0.5	-0.8
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.2	0.4	0.9	-0.1	0.4	-0.4	1.0
Eye problems/disorders: Glaucoma	1.0	1.2	3.1	-1.8	-1.1	1.7	0.8	-0.4	-0.7	0.2
Medication: Blood pressure	3.4	6.5	9.0	-2.6	-3.0	3.0	2.4	-2.9	-2.7	-0.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	0.9	1.2	-1.0	-0.6	1.0	1.6	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	-0.9	-1.3	1.1	1.6	-0.7	-1.3	-0.2
High cholesterol (Self-reported)	1.3	2.3	4.7	-2.2	-1.8	2.2	0.1	-1.3	-1.3	-0.3
Medication: Bendroflumethiazide	3.2	4.9	9.0	-2.3	-3.0	2.3	1.5	-3.0	-1.6	-1.2
Medication: Paracetamol	1.9	2.9	6.0	2.5	1.9	-2.2	-1.2	0.6	1.3	1.6
Medication: Lisinopril	3.7	4.8	8.4	-2.6	-2.4	2.9	2.0	-2.3	-1.9	0.7
Medication: Atorvastatin	0.3	0.4	1.4	0.4	-0.8	-0.4	-0.8	-1.2	0.3	-0.1
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.4	-1.0	0.5	-0.6	-0.4	-0.3	-1.0
Alcohol drinker status: Never	4.4	5.3	9.8	-1.5	-3.1	1.9	1.7	-2.9	-1.7	-2.7
Ever smoked	1.6	2.8	5.8	2.0	1.3	-2.3	-1.2	0.9	2.4	0.7
Basal metabolic rate	0.3	1.8	11.6	0.2	0.4	0.6	-0.1	-0.1	-3.4	0.7
Leg fat percentage (left)	0.5	1.8	8.1	-1.3	0.1	1.6	0.6	-0.1	0.1	2.8
Arm fat-free mass (left)	0.3	1.5	9.7	0.3	0.4	0.2	-0.1	-0.2	-3.1	0.7
Number of operations (self-reported)	0.5	0.7	2.5	0.5	0.0	-0.1	-0.5	-0.7	-1.6	-1.1
Average weekly beer plus cider intake	1.6	2.4	7.0	1.0	0.6	-1.2	0.6	1.2	2.6	2.2
Irritability	0.9	1.5	5.0	-1.0	-1.5	0.7	2.2	-1.2	0.5	-0.5
Risk taking	0.5	0.8	2.0	0.2	0.6	-0.7	0.7	0.5	1.3	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.4	0.9	0.7	-1.0	-1.6	1.0	1.2	-0.7
Fractured/broken bones in last 5 years	1.4	1.8	3.1	1.4	1.4	-1.8	0.3	1.4	1.6	1.0
Age started oral contraceptive pill	0.9	1.1	2.7	0.7	1.0	-1.0	-0.8	1.1	1.6	0.7
Diastolic blood pressure, automated reading	0.4	1.2	6.8	0.1	-0.3	0.0	1.0	0.1	0.7	2.6
Ever depressed for a whole week	0.4	0.5	1.9	-0.6	0.3	1.0	-0.5	-0.3	-1.4	-0.1
Unable to work because of sickness or disability	0.4	0.6	1.7	0.5	0.8	-0.4	0.8	0.5	-0.4	1.3
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.4	0.8	-0.2	0.3	-0.0	0.4	-0.7
Myopia	0.4	0.5	1.0	-0.1	-0.8	0.5	-0.7	-1.0	-0.9	-0.7
Vascular/heart problems diagnosed by doctor	4.2	11.4	19.7	4.1	3.8	-4.4	-3.8	2.7	2.1	-1.6
Cholesterol lowering medication	3.2	4.7	9.1	-2.7	-2.7	3.0	1.1	-2.2	-1.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.8	0.9	2.0	-1.1	-0.8	1.6	2.4	0.9
Pain experienced in last month	1.1	1.8	5.0	-1.6	-1.6	0.8	1.3	-0.8	-0.1	-2.2
Supplements: Calcium	0.1	0.1	0.5	-0.0	0.0	-0.4	-0.1	0.4	0.7	-0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.4	0.1	-0.5	-0.3	-0.4	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	0.8	0.7	-0.3	-1.2	1.4	0.2	0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.1	1.0	1.4	-0.9	-0.9	1.0	0.9	0.2
Heart disease (siblings)	0.8	1.0	3.7	-0.8	-0.9	0.8	1.9	0.3	0.2	0.9
Alcohol drinker status: Previous	0.6	0.7	1.9	-0.8	-0.7	0.8	0.5	-1.4	-0.6	0.7
Pack years of smoking	0.5	0.7	1.6	0.8	0.8	-1.1	-1.3	0.6	0.1	-0.3
Impedance of whole body	0.4	1.8	12.4	-0.1	0.1	-0.3	-0.1	0.2	3.5	-0.2
Leg fat mass (left)	0.5	2.1	6.3	-1.4	-0.2	2.0	0.9	-0.4	-1.1	2.5
Arm predicted mass (left)	0.3	1.6	10.0	0.3	0.5	0.3	-0.3	-0.1	-3.2	0.8