[Hub]/) : Traits : Reaction Time :

chr17:43,871,147-45,510,971

Best TWAS P=5.14e-24 · Best GWAS P=9.12e-20 conditioned to 0.803

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous KANSL1 0.35 0.09 enet 13 0.12 1.1e-09 -8.16 9.1 6.0e-20 -0.70 0.00 1.00 FALSE
2 GTEx Adipose Subcutaneous ARL17A 0.58 0.25 lasso 5 0.37 1.3e-31 -8.51 -9.7 2.8e-22 0.89 0.00 1.00 FALSE
3 GTEx Adipose Subcutaneous NSFP1 0.58 0.18 enet 30 0.34 2.5e-28 -9.10 -9.4 4.7e-21 0.78 0.00 1.00 FALSE
4 GTEx Adipose Visceral Omentum ARL17A 0.51 0.21 lasso 7 0.27 1.7e-14 -9.10 -9.9 3.0e-23 0.91 0.00 1.00 FALSE
5 GTEx Adipose Visceral Omentum NSFP1 0.56 0.20 lasso 8 0.27 3.7e-14 -8.51 -9.3 1.2e-20 0.86 0.01 0.99 FALSE
6 GTEx Adrenal Gland ARL17A 0.52 0.01 lasso 7 0.19 2.2e-07 -9.10 -9.4 4.2e-21 0.79 0.00 1.00 FALSE
7 GTEx Adrenal Gland ARL17B 0.40 -0.01 enet 20 0.17 9.5e-07 -2.92 -7.0 3.6e-12 0.61 0.01 0.77 FALSE
8 GTEx Adrenal Gland NSFP1 0.43 0.07 enet 30 0.18 3.5e-07 -9.10 -8.8 1.4e-18 0.74 0.00 0.98 FALSE
9 GTEx Artery Aorta KANSL1 0.42 0.08 lasso 4 0.14 2.4e-08 -8.16 8.8 1.8e-18 -0.64 0.00 0.98 FALSE
10 GTEx Artery Aorta ARL17A 0.61 0.28 lasso 5 0.42 8.2e-25 -9.10 -9.8 1.6e-22 0.82 0.00 1.00 FALSE
11 GTEx Artery Aorta NSFP1 0.40 0.19 lasso 5 0.24 3.3e-13 -9.10 -9.8 1.9e-22 0.90 0.00 1.00 FALSE
12 GTEx Artery Coronary ARL17A 0.39 0.19 lasso 5 0.20 3.0e-07 -9.10 -9.8 8.6e-23 0.94 0.00 1.00 FALSE
13 GTEx Artery Tibial KANSL1 0.31 0.07 lasso 6 0.07 1.7e-06 -8.16 8.9 7.3e-19 -0.72 0.00 1.00 FALSE
14 GTEx Artery Tibial ARL17A 0.69 0.37 lasso 9 0.44 5.4e-38 -9.10 -9.9 6.1e-23 0.92 0.00 1.00 FALSE
15 GTEx Artery Tibial NSFP1 0.52 0.18 lasso 7 0.29 7.1e-23 -9.10 -9.9 3.5e-23 0.90 0.00 1.00 FALSE
16 GTEx Brain Caudate basal ganglia LRRC37A 0.58 0.27 lasso 14 0.57 1.6e-19 0.15 -6.5 6.4e-11 0.44 0.48 0.48 FALSE
17 GTEx Brain Cerebellar Hemisphere ARL17A 0.69 0.23 lasso 14 0.28 8.3e-08 -9.10 -9.8 1.1e-22 0.90 0.00 1.00 FALSE
18 GTEx Brain Cerebellum ARL17A 0.69 0.35 lasso 13 0.44 2.1e-14 -9.10 -9.4 3.2e-21 0.95 0.00 1.00 FALSE
19 GTEx Brain Cerebellum NSFP1 0.38 0.24 enet 18 0.27 1.4e-08 -9.10 -9.8 9.2e-23 0.95 0.00 1.00 FALSE
20 GTEx Brain Cortex LRRC37A 0.60 0.06 lasso 9 0.44 1.2e-13 -8.51 -7.1 1.1e-12 0.55 0.02 0.94 FALSE
21 GTEx Brain Cortex ARL17A 0.35 0.20 lasso 6 0.25 1.7e-07 -9.10 -9.3 2.1e-20 0.84 0.00 0.99 FALSE
22 GTEx Brain Cortex ARL17B 0.49 0.19 enet 23 0.31 2.4e-09 -9.10 -5.5 3.7e-08 0.69 0.00 0.98 FALSE
23 GTEx Brain Frontal Cortex BA9 LRRC37A 0.71 0.09 lasso 7 0.49 6.0e-15 -9.10 -7.5 6.5e-14 0.55 0.01 0.98 FALSE
24 GTEx Brain Frontal Cortex BA9 ARL17A 0.46 0.29 lasso 5 0.28 4.7e-08 -9.10 -9.6 6.1e-22 0.96 0.00 1.00 FALSE
25 GTEx Brain Frontal Cortex BA9 ARL17B 0.30 0.13 enet 16 0.15 7.1e-05 -9.10 -7.0 2.9e-12 0.74 0.00 0.87 FALSE
26 GTEx Brain Hippocampus LRRC37A 0.52 0.18 enet 27 0.44 1.2e-11 1.12 -6.2 5.0e-10 0.39 0.44 0.22 FALSE
27 GTEx Brain Hypothalamus LRRC37A 0.69 0.28 enet 34 0.61 7.6e-18 0.15 -6.6 3.3e-11 0.46 0.83 0.14 FALSE
28 GTEx Brain Nucleus accumbens basal ganglia LRRC37A 0.60 0.27 lasso 13 0.56 6.6e-18 0.15 -6.9 6.2e-12 0.50 0.15 0.82 FALSE
29 GTEx Brain Nucleus accumbens basal ganglia ARL17A 0.33 0.24 lasso 10 0.21 2.7e-06 -9.10 -9.4 4.0e-21 0.93 0.00 0.99 FALSE
30 GTEx Brain Nucleus accumbens basal ganglia ARL17B 0.28 0.17 enet 9 0.19 7.1e-06 -9.10 -8.3 7.1e-17 0.81 0.00 0.96 FALSE
31 GTEx Brain Putamen basal ganglia LRRC37A 0.47 0.12 enet 27 0.36 2.3e-09 0.34 -5.5 3.1e-08 0.30 0.43 0.13 FALSE
32 GTEx Breast Mammary Tissue KANSL1 0.31 0.00 enet 9 0.11 2.6e-06 -8.16 6.4 1.3e-10 -0.38 0.00 0.68 FALSE
33 GTEx Breast Mammary Tissue ARL17A 0.63 0.24 lasso 7 0.34 4.2e-18 -8.51 -9.6 5.6e-22 0.87 0.00 1.00 FALSE
34 GTEx Breast Mammary Tissue NSFP1 0.52 0.26 lasso 6 0.30 1.0e-15 -8.51 -9.6 1.4e-21 0.86 0.02 0.98 FALSE
35 GTEx Breast Mammary Tissue (Male) ARL17A 0.45 0.15 lasso 8 0.09 4.3e-03 -8.51 -9.2 2.6e-20 0.81 0.00 0.74 FALSE
36 GTEx Breast Mammary Tissue (Male) NSFP1 0.28 0.02 lasso 4 0.01 1.9e-01 -8.51 -9.2 5.0e-20 0.87 0.00 0.75 FALSE
37 GTEx Breast Mammary Tissue (Female) ARL17A 0.63 0.23 enet 17 0.32 3.2e-10 -8.51 -9.6 1.2e-21 0.79 0.00 1.00 FALSE
38 GTEx Breast Mammary Tissue (Female) ARL17B 0.11 -0.01 enet 18 0.03 4.0e-02 -8.51 -6.5 1.1e-10 0.70 0.02 0.64 FALSE
39 GTEx Breast Mammary Tissue (Female) NSFP1 0.54 0.21 lasso 5 0.26 1.6e-08 -8.51 -9.6 5.7e-22 0.89 0.00 0.99 FALSE
40 GTEx Cells EBV-transformed lymphocytes NSF 0.20 0.07 lasso 2 0.10 3.4e-04 -8.28 6.9 5.6e-12 -0.70 0.03 0.78 FALSE
41 GTEx Cells EBV-transformed lymphocytes KANSL1 0.50 0.14 lasso 5 0.30 2.4e-10 -8.16 5.7 1.0e-08 -0.64 0.00 0.99 FALSE
42 GTEx Cells Transformed fibroblasts LRRC37A 0.53 0.18 enet 26 0.36 7.3e-28 0.77 -5.7 1.6e-08 0.27 1.00 0.00 FALSE
43 GTEx Cells Transformed fibroblasts ARL17A 0.35 0.12 enet 23 0.22 3.9e-16 -8.51 -9.8 1.6e-22 0.81 0.00 1.00 FALSE
44 GTEx Cells Transformed fibroblasts ARL17B 0.55 0.16 enet 21 0.31 2.4e-23 -9.10 -8.6 7.5e-18 0.71 0.00 1.00 FALSE
45 GTEx Cells Transformed fibroblasts NSFP1 0.28 0.11 enet 19 0.19 4.4e-14 -9.10 -9.5 2.2e-21 0.69 0.00 1.00 FALSE
46 GTEx Colon Sigmoid ARL17A 0.66 0.47 lasso 10 0.50 4.2e-20 -9.10 -9.5 1.9e-21 0.97 0.00 1.00 FALSE
47 GTEx Colon Sigmoid ARL17B 0.36 -0.01 lasso 10 0.10 2.1e-04 -8.51 -6.0 2.4e-09 0.72 0.01 0.78 FALSE
48 GTEx Colon Sigmoid NSFP1 0.51 0.28 enet 11 0.33 2.3e-12 -9.10 -9.8 1.4e-22 0.89 0.00 1.00 FALSE
49 GTEx Colon Transverse ARL17A 0.64 0.14 lasso 4 0.22 5.2e-11 -8.51 -9.6 1.3e-21 0.79 0.01 0.99 FALSE
50 GTEx Colon Transverse NSFP1 0.33 0.06 enet 12 0.19 2.5e-09 -8.51 -8.8 1.2e-18 0.63 0.00 0.99 FALSE
51 GTEx Esophagus Gastroesophageal Junction ARL17A 0.53 0.26 enet 9 0.37 2.0e-14 -8.51 -10.1 5.1e-24 0.89 0.00 1.00 TRUE
52 GTEx Esophagus Gastroesophageal Junction ARL17B 0.15 0.06 enet 20 0.12 3.0e-05 -8.51 -6.4 1.2e-10 0.64 0.02 0.93 FALSE
53 GTEx Esophagus Gastroesophageal Junction NSFP1 0.46 0.24 lasso 4 0.30 3.2e-11 -9.10 -9.5 1.9e-21 0.95 0.00 1.00 FALSE
54 GTEx Esophagus Mucosa KANSL1 0.23 0.08 lasso 3 0.08 9.3e-06 -8.16 8.0 1.7e-15 -0.76 0.00 1.00 FALSE
55 GTEx Esophagus Mucosa LRRC37A 0.46 0.13 lasso 12 0.30 4.1e-20 0.12 -5.6 2.0e-08 0.29 1.00 0.00 FALSE
56 GTEx Esophagus Mucosa ARL17A 0.32 0.12 enet 9 0.18 8.6e-12 -9.10 -9.9 2.7e-23 0.81 0.00 1.00 FALSE
57 GTEx Esophagus Mucosa NSFP1 0.49 0.05 lasso 11 0.22 9.1e-15 -8.51 -9.4 4.3e-21 0.65 0.00 1.00 FALSE
58 GTEx Esophagus Muscularis NSF 0.17 0.00 enet 17 0.01 1.4e-01 -8.28 -7.3 3.9e-13 0.67 0.01 0.88 FALSE
59 GTEx Esophagus Muscularis KANSL1 0.41 0.11 enet 8 0.15 1.3e-09 -8.16 8.5 1.7e-17 -0.59 0.00 1.00 FALSE
60 GTEx Esophagus Muscularis ARL17A 0.57 0.32 lasso 4 0.40 4.1e-26 -8.51 -9.7 3.3e-22 0.93 0.00 1.00 FALSE
61 GTEx Esophagus Muscularis NSFP1 0.42 0.22 enet 16 0.24 5.0e-15 -9.10 -10.0 1.7e-23 0.90 0.00 1.00 FALSE
62 GTEx Heart Atrial Appendage ARL17A 0.39 0.20 lasso 4 0.22 5.3e-10 -9.10 -9.7 2.6e-22 0.94 0.00 1.00 FALSE
63 GTEx Heart Atrial Appendage NSFP1 0.47 0.25 lasso 4 0.29 2.4e-13 -9.10 -9.9 3.7e-23 0.94 0.00 1.00 FALSE
64 GTEx Heart Left Ventricle ARL17A 0.30 0.15 enet 19 0.15 2.4e-08 -9.10 -9.6 6.6e-22 0.78 0.00 1.00 FALSE
65 GTEx Heart Left Ventricle NSFP1 0.29 0.15 enet 18 0.19 2.1e-10 -9.10 -9.2 4.1e-20 0.82 0.00 1.00 FALSE
66 GTEx Liver LRRC37A 0.42 0.07 lasso 6 0.24 1.9e-07 0.78 -6.3 3.9e-10 0.43 0.07 0.70 FALSE
67 GTEx Liver ARL17A 0.34 0.18 lasso 9 0.18 9.8e-06 -9.10 -10.0 1.5e-23 0.86 0.00 0.97 FALSE
68 GTEx Liver NSFP1 0.27 0.24 lasso 2 0.22 6.3e-07 -9.10 -9.2 3.5e-20 1.00 0.00 1.00 FALSE
69 GTEx Lung KANSL1 0.34 0.07 enet 30 0.11 1.7e-08 -8.16 8.4 3.1e-17 -0.50 0.00 1.00 FALSE
70 GTEx Lung ARL17A 0.50 0.19 lasso 6 0.28 2.6e-21 -8.51 -9.9 2.7e-23 0.88 0.00 1.00 FALSE
71 GTEx Lung NSFP1 0.55 0.18 lasso 9 0.33 4.8e-26 -9.10 -9.2 3.1e-20 0.79 0.00 1.00 FALSE
72 GTEx Muscle Skeletal KANSL1 0.10 0.05 enet 9 0.04 1.7e-04 -8.16 8.3 9.1e-17 -0.65 0.00 1.00 FALSE
73 GTEx Muscle Skeletal LRRC37A 0.45 0.13 enet 14 0.39 1.3e-40 0.78 -7.1 1.4e-12 0.48 0.57 0.43 FALSE
74 GTEx Muscle Skeletal ARL17A 0.44 0.12 enet 27 0.16 1.4e-15 -9.10 -9.6 8.1e-22 0.80 0.00 1.00 FALSE
75 GTEx Muscle Skeletal ARL17B 0.26 0.02 enet 19 0.06 6.3e-07 -9.10 -5.6 2.7e-08 0.63 0.00 1.00 FALSE
76 GTEx Muscle Skeletal NSFP1 0.41 0.12 enet 22 0.22 1.1e-21 -9.10 -9.4 5.7e-21 0.82 0.00 1.00 FALSE
77 GTEx Nerve Tibial KANSL1 0.31 0.06 lasso 2 0.13 3.4e-09 -8.16 8.4 4.5e-17 -0.58 0.00 0.98 FALSE
78 GTEx Nerve Tibial ARL17A 0.65 0.25 lasso 5 0.40 2.6e-30 -9.10 -9.8 8.0e-23 0.86 0.00 1.00 FALSE
79 GTEx Nerve Tibial NSFP1 0.59 0.17 enet 15 0.28 6.3e-20 -9.10 -10.1 5.3e-24 0.84 0.00 1.00 FALSE
80 GTEx Ovary KANSL1 0.15 0.04 lasso 3 0.10 2.1e-03 -8.16 6.6 5.1e-11 -0.69 0.00 0.74 FALSE
81 GTEx Ovary ARL17A 0.42 0.15 enet 5 0.16 9.6e-05 -9.10 -8.1 6.8e-16 0.87 0.00 0.99 FALSE
82 GTEx Pancreas ARL17B 0.26 0.05 enet 16 0.09 1.1e-04 -9.10 -5.4 6.2e-08 0.62 0.00 0.92 FALSE
83 GTEx Pituitary KANSL1 0.58 0.24 lasso 4 0.24 8.9e-07 -8.16 8.3 1.3e-16 -0.75 0.00 0.99 FALSE
84 GTEx Pituitary LRRC37A 0.66 0.17 lasso 22 0.45 7.5e-13 0.15 -6.6 4.6e-11 0.46 0.16 0.63 FALSE
85 GTEx Pituitary ARL17A 0.63 0.43 lasso 6 0.42 8.6e-12 -9.10 -9.6 5.6e-22 0.99 0.00 1.00 FALSE
86 GTEx Pituitary ARL17B 0.27 0.22 enet 6 0.21 4.7e-06 -9.10 -8.8 2.0e-18 0.87 0.00 0.98 FALSE
87 GTEx Pituitary NSFP1 0.52 0.36 lasso 5 0.36 5.6e-10 -9.10 -9.6 1.1e-21 0.96 0.00 1.00 FALSE
88 GTEx Prostate ARL17A 0.52 0.08 enet 14 0.21 5.1e-06 -2.92 -7.4 1.4e-13 0.60 0.01 0.61 FALSE
89 GTEx Skin Not Sun Exposed Suprapubic ARL17A 0.32 0.10 enet 8 0.12 3.5e-07 -9.10 -9.9 4.6e-23 0.85 0.00 1.00 FALSE
90 GTEx Skin Not Sun Exposed Suprapubic NSFP1 0.54 0.29 enet 17 0.37 1.8e-21 -9.10 -9.7 2.1e-22 0.83 0.00 1.00 FALSE
91 GTEx Skin Sun Exposed Lower leg KANSL1 0.39 0.11 enet 20 0.16 6.8e-13 -8.16 7.5 9.4e-14 -0.66 0.00 1.00 FALSE
92 GTEx Skin Sun Exposed Lower leg ARL17A 0.53 0.21 lasso 9 0.29 7.3e-24 -9.10 -9.9 2.7e-23 0.90 0.00 1.00 FALSE
93 GTEx Skin Sun Exposed Lower leg NSFP1 0.55 0.22 lasso 7 0.30 5.3e-25 -9.10 -9.7 3.8e-22 0.89 0.00 1.00 FALSE
94 GTEx Spleen NSFP1 0.41 0.02 enet 11 0.11 1.0e-03 -2.27 -5.3 9.4e-08 0.23 0.02 0.11 FALSE
95 GTEx Stomach ARL17A 0.42 0.17 lasso 5 0.24 5.8e-12 -8.51 -9.2 2.3e-20 0.76 0.02 0.98 FALSE
96 GTEx Stomach NSFP1 0.50 0.11 enet 46 0.18 4.9e-09 -9.10 -8.3 1.1e-16 0.54 0.00 0.99 FALSE
97 GTEx Testis KANSL1 0.19 0.05 enet 10 0.09 6.6e-05 0.64 6.5 1.1e-10 -0.26 0.01 0.12 FALSE
98 GTEx Testis LRRC37A 0.71 0.46 enet 10 0.55 5.7e-29 -9.10 -10.0 1.7e-23 0.85 0.00 1.00 FALSE
99 GTEx Testis ARL17A 0.60 0.28 enet 14 0.36 1.1e-16 -9.10 -9.5 1.5e-21 0.77 0.00 1.00 FALSE
100 GTEx Testis LRRC37A2 0.78 0.38 enet 47 0.54 3.0e-28 -9.10 -9.1 6.4e-20 0.71 0.00 1.00 FALSE
101 GTEx Testis NSFP1 0.66 0.09 lasso 10 0.38 1.0e-17 -3.03 -8.0 1.9e-15 0.48 0.14 0.82 FALSE
102 GTEx Thyroid KANSL1 0.26 0.02 enet 16 0.10 7.8e-08 1.36 5.3 1.2e-07 -0.23 0.07 0.34 FALSE
103 GTEx Thyroid ARL17A 0.48 0.19 lasso 7 0.24 2.2e-18 -9.10 -9.8 1.4e-22 0.84 0.00 1.00 FALSE
104 GTEx Thyroid NSFP1 0.42 0.17 enet 14 0.27 4.6e-21 -9.10 -9.8 1.3e-22 0.80 0.00 1.00 FALSE
105 GTEx Whole Blood NSFP1 0.25 0.05 enet 22 0.12 1.0e-10 -9.10 -9.2 5.8e-20 0.71 0.00 1.00 FALSE
106 METSIM Adipose ARL17B 0.34 0.08 bslmm 88 0.10 3.4e-15 -9.10 -8.0 1.8e-15 0.71 0.00 1.00 FALSE
107 METSIM Adipose LRRC37A 0.56 0.25 lasso 5 0.32 5.5e-49 -9.10 -10.0 1.7e-23 0.92 0.00 1.00 FALSE
108 The Cancer Genome Atlas Bladder Urothelial Carcinoma ARL17A 0.14 0.00 enet 15 0.05 3.6e-05 -9.10 -5.8 6.7e-09 0.55 0.00 0.78 FALSE
109 The Cancer Genome Atlas Breast Invasive Carcinoma ARL17A 0.18 0.05 lasso 8 0.11 3.0e-21 0.15 -6.4 1.8e-10 0.40 1.00 0.00 FALSE
110 The Cancer Genome Atlas Colon Adenocarcinoma ARL17A 0.35 0.00 lasso 6 0.09 4.4e-06 -2.09 -7.0 2.3e-12 0.34 0.10 0.33 FALSE
111 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ARL17A 0.16 0.01 enet 8 0.05 3.2e-06 -8.51 -6.8 1.1e-11 0.39 0.04 0.20 FALSE
112 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ARL17A 0.20 0.02 lasso 2 0.07 9.7e-09 -8.51 -6.9 6.6e-12 0.46 0.02 0.74 FALSE
113 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ARL17A 0.13 0.02 lasso 3 0.07 2.8e-05 -8.51 -6.5 9.4e-11 0.51 0.02 0.55 FALSE
114 The Cancer Genome Atlas Soft Tissue Sarcoma LRRC37A2 0.43 0.26 enet 22 0.37 3.8e-23 1.00 6.1 9.3e-10 -0.60 1.00 0.00 FALSE
115 The Cancer Genome Atlas Testicular Germ Cell Tumors LRRC37A2 0.40 0.14 lasso 6 0.21 4.4e-08 -8.16 6.6 3.1e-11 -0.71 0.11 0.86 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma ARL17A 0.37 0.02 lasso 9 0.17 1.3e-16 0.62 -6.1 9.7e-10 0.39 0.80 0.20 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma KIAA1267 0.09 0.03 lasso 3 0.01 7.5e-02 -8.16 8.8 1.8e-18 -0.75 0.00 0.89 FALSE