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chr17:43,871,147-45,510,971

Best TWAS P=5.14e-24 · Best GWAS P=9.12e-20 conditioned to 0.803

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	KANSL1	0.35	0.09	enet	13	0.12	1.1e-09	-8.16	9.1	6.0e-20	-0.70	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	ARL17A	0.58	0.25	lasso	5	0.37	1.3e-31	-8.51	-9.7	2.8e-22	0.89	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	NSFP1	0.58	0.18	enet	30	0.34	2.5e-28	-9.10	-9.4	4.7e-21	0.78	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	ARL17A	0.51	0.21	lasso	7	0.27	1.7e-14	-9.10	-9.9	3.0e-23	0.91	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	NSFP1	0.56	0.20	lasso	8	0.27	3.7e-14	-8.51	-9.3	1.2e-20	0.86	0.01	0.99	FALSE
6	GTEx	Adrenal Gland	ARL17A	0.52	0.01	lasso	7	0.19	2.2e-07	-9.10	-9.4	4.2e-21	0.79	0.00	1.00	FALSE
7	GTEx	Adrenal Gland	ARL17B	0.40	-0.01	enet	20	0.17	9.5e-07	-2.92	-7.0	3.6e-12	0.61	0.01	0.77	FALSE
8	GTEx	Adrenal Gland	NSFP1	0.43	0.07	enet	30	0.18	3.5e-07	-9.10	-8.8	1.4e-18	0.74	0.00	0.98	FALSE
9	GTEx	Artery Aorta	KANSL1	0.42	0.08	lasso	4	0.14	2.4e-08	-8.16	8.8	1.8e-18	-0.64	0.00	0.98	FALSE
10	GTEx	Artery Aorta	ARL17A	0.61	0.28	lasso	5	0.42	8.2e-25	-9.10	-9.8	1.6e-22	0.82	0.00	1.00	FALSE
11	GTEx	Artery Aorta	NSFP1	0.40	0.19	lasso	5	0.24	3.3e-13	-9.10	-9.8	1.9e-22	0.90	0.00	1.00	FALSE
12	GTEx	Artery Coronary	ARL17A	0.39	0.19	lasso	5	0.20	3.0e-07	-9.10	-9.8	8.6e-23	0.94	0.00	1.00	FALSE
13	GTEx	Artery Tibial	KANSL1	0.31	0.07	lasso	6	0.07	1.7e-06	-8.16	8.9	7.3e-19	-0.72	0.00	1.00	FALSE
14	GTEx	Artery Tibial	ARL17A	0.69	0.37	lasso	9	0.44	5.4e-38	-9.10	-9.9	6.1e-23	0.92	0.00	1.00	FALSE
15	GTEx	Artery Tibial	NSFP1	0.52	0.18	lasso	7	0.29	7.1e-23	-9.10	-9.9	3.5e-23	0.90	0.00	1.00	FALSE
16	GTEx	Brain Caudate basal ganglia	LRRC37A	0.58	0.27	lasso	14	0.57	1.6e-19	0.15	-6.5	6.4e-11	0.44	0.48	0.48	FALSE
17	GTEx	Brain Cerebellar Hemisphere	ARL17A	0.69	0.23	lasso	14	0.28	8.3e-08	-9.10	-9.8	1.1e-22	0.90	0.00	1.00	FALSE
18	GTEx	Brain Cerebellum	ARL17A	0.69	0.35	lasso	13	0.44	2.1e-14	-9.10	-9.4	3.2e-21	0.95	0.00	1.00	FALSE
19	GTEx	Brain Cerebellum	NSFP1	0.38	0.24	enet	18	0.27	1.4e-08	-9.10	-9.8	9.2e-23	0.95	0.00	1.00	FALSE
20	GTEx	Brain Cortex	LRRC37A	0.60	0.06	lasso	9	0.44	1.2e-13	-8.51	-7.1	1.1e-12	0.55	0.02	0.94	FALSE
21	GTEx	Brain Cortex	ARL17A	0.35	0.20	lasso	6	0.25	1.7e-07	-9.10	-9.3	2.1e-20	0.84	0.00	0.99	FALSE
22	GTEx	Brain Cortex	ARL17B	0.49	0.19	enet	23	0.31	2.4e-09	-9.10	-5.5	3.7e-08	0.69	0.00	0.98	FALSE
23	GTEx	Brain Frontal Cortex BA9	LRRC37A	0.71	0.09	lasso	7	0.49	6.0e-15	-9.10	-7.5	6.5e-14	0.55	0.01	0.98	FALSE
24	GTEx	Brain Frontal Cortex BA9	ARL17A	0.46	0.29	lasso	5	0.28	4.7e-08	-9.10	-9.6	6.1e-22	0.96	0.00	1.00	FALSE
25	GTEx	Brain Frontal Cortex BA9	ARL17B	0.30	0.13	enet	16	0.15	7.1e-05	-9.10	-7.0	2.9e-12	0.74	0.00	0.87	FALSE
26	GTEx	Brain Hippocampus	LRRC37A	0.52	0.18	enet	27	0.44	1.2e-11	1.12	-6.2	5.0e-10	0.39	0.44	0.22	FALSE
27	GTEx	Brain Hypothalamus	LRRC37A	0.69	0.28	enet	34	0.61	7.6e-18	0.15	-6.6	3.3e-11	0.46	0.83	0.14	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	LRRC37A	0.60	0.27	lasso	13	0.56	6.6e-18	0.15	-6.9	6.2e-12	0.50	0.15	0.82	FALSE
29	GTEx	Brain Nucleus accumbens basal ganglia	ARL17A	0.33	0.24	lasso	10	0.21	2.7e-06	-9.10	-9.4	4.0e-21	0.93	0.00	0.99	FALSE
30	GTEx	Brain Nucleus accumbens basal ganglia	ARL17B	0.28	0.17	enet	9	0.19	7.1e-06	-9.10	-8.3	7.1e-17	0.81	0.00	0.96	FALSE
31	GTEx	Brain Putamen basal ganglia	LRRC37A	0.47	0.12	enet	27	0.36	2.3e-09	0.34	-5.5	3.1e-08	0.30	0.43	0.13	FALSE
32	GTEx	Breast Mammary Tissue	KANSL1	0.31	0.00	enet	9	0.11	2.6e-06	-8.16	6.4	1.3e-10	-0.38	0.00	0.68	FALSE
33	GTEx	Breast Mammary Tissue	ARL17A	0.63	0.24	lasso	7	0.34	4.2e-18	-8.51	-9.6	5.6e-22	0.87	0.00	1.00	FALSE
34	GTEx	Breast Mammary Tissue	NSFP1	0.52	0.26	lasso	6	0.30	1.0e-15	-8.51	-9.6	1.4e-21	0.86	0.02	0.98	FALSE
35	GTEx	Breast Mammary Tissue (Male)	ARL17A	0.45	0.15	lasso	8	0.09	4.3e-03	-8.51	-9.2	2.6e-20	0.81	0.00	0.74	FALSE
36	GTEx	Breast Mammary Tissue (Male)	NSFP1	0.28	0.02	lasso	4	0.01	1.9e-01	-8.51	-9.2	5.0e-20	0.87	0.00	0.75	FALSE
37	GTEx	Breast Mammary Tissue (Female)	ARL17A	0.63	0.23	enet	17	0.32	3.2e-10	-8.51	-9.6	1.2e-21	0.79	0.00	1.00	FALSE
38	GTEx	Breast Mammary Tissue (Female)	ARL17B	0.11	-0.01	enet	18	0.03	4.0e-02	-8.51	-6.5	1.1e-10	0.70	0.02	0.64	FALSE
39	GTEx	Breast Mammary Tissue (Female)	NSFP1	0.54	0.21	lasso	5	0.26	1.6e-08	-8.51	-9.6	5.7e-22	0.89	0.00	0.99	FALSE
40	GTEx	Cells EBV-transformed lymphocytes	NSF	0.20	0.07	lasso	2	0.10	3.4e-04	-8.28	6.9	5.6e-12	-0.70	0.03	0.78	FALSE
41	GTEx	Cells EBV-transformed lymphocytes	KANSL1	0.50	0.14	lasso	5	0.30	2.4e-10	-8.16	5.7	1.0e-08	-0.64	0.00	0.99	FALSE
42	GTEx	Cells Transformed fibroblasts	LRRC37A	0.53	0.18	enet	26	0.36	7.3e-28	0.77	-5.7	1.6e-08	0.27	1.00	0.00	FALSE
43	GTEx	Cells Transformed fibroblasts	ARL17A	0.35	0.12	enet	23	0.22	3.9e-16	-8.51	-9.8	1.6e-22	0.81	0.00	1.00	FALSE
44	GTEx	Cells Transformed fibroblasts	ARL17B	0.55	0.16	enet	21	0.31	2.4e-23	-9.10	-8.6	7.5e-18	0.71	0.00	1.00	FALSE
45	GTEx	Cells Transformed fibroblasts	NSFP1	0.28	0.11	enet	19	0.19	4.4e-14	-9.10	-9.5	2.2e-21	0.69	0.00	1.00	FALSE
46	GTEx	Colon Sigmoid	ARL17A	0.66	0.47	lasso	10	0.50	4.2e-20	-9.10	-9.5	1.9e-21	0.97	0.00	1.00	FALSE
47	GTEx	Colon Sigmoid	ARL17B	0.36	-0.01	lasso	10	0.10	2.1e-04	-8.51	-6.0	2.4e-09	0.72	0.01	0.78	FALSE
48	GTEx	Colon Sigmoid	NSFP1	0.51	0.28	enet	11	0.33	2.3e-12	-9.10	-9.8	1.4e-22	0.89	0.00	1.00	FALSE
49	GTEx	Colon Transverse	ARL17A	0.64	0.14	lasso	4	0.22	5.2e-11	-8.51	-9.6	1.3e-21	0.79	0.01	0.99	FALSE
50	GTEx	Colon Transverse	NSFP1	0.33	0.06	enet	12	0.19	2.5e-09	-8.51	-8.8	1.2e-18	0.63	0.00	0.99	FALSE
51	GTEx	Esophagus Gastroesophageal Junction	ARL17A	0.53	0.26	enet	9	0.37	2.0e-14	-8.51	-10.1	5.1e-24	0.89	0.00	1.00	TRUE
52	GTEx	Esophagus Gastroesophageal Junction	ARL17B	0.15	0.06	enet	20	0.12	3.0e-05	-8.51	-6.4	1.2e-10	0.64	0.02	0.93	FALSE
53	GTEx	Esophagus Gastroesophageal Junction	NSFP1	0.46	0.24	lasso	4	0.30	3.2e-11	-9.10	-9.5	1.9e-21	0.95	0.00	1.00	FALSE
54	GTEx	Esophagus Mucosa	KANSL1	0.23	0.08	lasso	3	0.08	9.3e-06	-8.16	8.0	1.7e-15	-0.76	0.00	1.00	FALSE
55	GTEx	Esophagus Mucosa	LRRC37A	0.46	0.13	lasso	12	0.30	4.1e-20	0.12	-5.6	2.0e-08	0.29	1.00	0.00	FALSE
56	GTEx	Esophagus Mucosa	ARL17A	0.32	0.12	enet	9	0.18	8.6e-12	-9.10	-9.9	2.7e-23	0.81	0.00	1.00	FALSE
57	GTEx	Esophagus Mucosa	NSFP1	0.49	0.05	lasso	11	0.22	9.1e-15	-8.51	-9.4	4.3e-21	0.65	0.00	1.00	FALSE
58	GTEx	Esophagus Muscularis	NSF	0.17	0.00	enet	17	0.01	1.4e-01	-8.28	-7.3	3.9e-13	0.67	0.01	0.88	FALSE
59	GTEx	Esophagus Muscularis	KANSL1	0.41	0.11	enet	8	0.15	1.3e-09	-8.16	8.5	1.7e-17	-0.59	0.00	1.00	FALSE
60	GTEx	Esophagus Muscularis	ARL17A	0.57	0.32	lasso	4	0.40	4.1e-26	-8.51	-9.7	3.3e-22	0.93	0.00	1.00	FALSE
61	GTEx	Esophagus Muscularis	NSFP1	0.42	0.22	enet	16	0.24	5.0e-15	-9.10	-10.0	1.7e-23	0.90	0.00	1.00	FALSE
62	GTEx	Heart Atrial Appendage	ARL17A	0.39	0.20	lasso	4	0.22	5.3e-10	-9.10	-9.7	2.6e-22	0.94	0.00	1.00	FALSE
63	GTEx	Heart Atrial Appendage	NSFP1	0.47	0.25	lasso	4	0.29	2.4e-13	-9.10	-9.9	3.7e-23	0.94	0.00	1.00	FALSE
64	GTEx	Heart Left Ventricle	ARL17A	0.30	0.15	enet	19	0.15	2.4e-08	-9.10	-9.6	6.6e-22	0.78	0.00	1.00	FALSE
65	GTEx	Heart Left Ventricle	NSFP1	0.29	0.15	enet	18	0.19	2.1e-10	-9.10	-9.2	4.1e-20	0.82	0.00	1.00	FALSE
66	GTEx	Liver	LRRC37A	0.42	0.07	lasso	6	0.24	1.9e-07	0.78	-6.3	3.9e-10	0.43	0.07	0.70	FALSE
67	GTEx	Liver	ARL17A	0.34	0.18	lasso	9	0.18	9.8e-06	-9.10	-10.0	1.5e-23	0.86	0.00	0.97	FALSE
68	GTEx	Liver	NSFP1	0.27	0.24	lasso	2	0.22	6.3e-07	-9.10	-9.2	3.5e-20	1.00	0.00	1.00	FALSE
69	GTEx	Lung	KANSL1	0.34	0.07	enet	30	0.11	1.7e-08	-8.16	8.4	3.1e-17	-0.50	0.00	1.00	FALSE
70	GTEx	Lung	ARL17A	0.50	0.19	lasso	6	0.28	2.6e-21	-8.51	-9.9	2.7e-23	0.88	0.00	1.00	FALSE
71	GTEx	Lung	NSFP1	0.55	0.18	lasso	9	0.33	4.8e-26	-9.10	-9.2	3.1e-20	0.79	0.00	1.00	FALSE
72	GTEx	Muscle Skeletal	KANSL1	0.10	0.05	enet	9	0.04	1.7e-04	-8.16	8.3	9.1e-17	-0.65	0.00	1.00	FALSE
73	GTEx	Muscle Skeletal	LRRC37A	0.45	0.13	enet	14	0.39	1.3e-40	0.78	-7.1	1.4e-12	0.48	0.57	0.43	FALSE
74	GTEx	Muscle Skeletal	ARL17A	0.44	0.12	enet	27	0.16	1.4e-15	-9.10	-9.6	8.1e-22	0.80	0.00	1.00	FALSE
75	GTEx	Muscle Skeletal	ARL17B	0.26	0.02	enet	19	0.06	6.3e-07	-9.10	-5.6	2.7e-08	0.63	0.00	1.00	FALSE
76	GTEx	Muscle Skeletal	NSFP1	0.41	0.12	enet	22	0.22	1.1e-21	-9.10	-9.4	5.7e-21	0.82	0.00	1.00	FALSE
77	GTEx	Nerve Tibial	KANSL1	0.31	0.06	lasso	2	0.13	3.4e-09	-8.16	8.4	4.5e-17	-0.58	0.00	0.98	FALSE
78	GTEx	Nerve Tibial	ARL17A	0.65	0.25	lasso	5	0.40	2.6e-30	-9.10	-9.8	8.0e-23	0.86	0.00	1.00	FALSE
79	GTEx	Nerve Tibial	NSFP1	0.59	0.17	enet	15	0.28	6.3e-20	-9.10	-10.1	5.3e-24	0.84	0.00	1.00	FALSE
80	GTEx	Ovary	KANSL1	0.15	0.04	lasso	3	0.10	2.1e-03	-8.16	6.6	5.1e-11	-0.69	0.00	0.74	FALSE
81	GTEx	Ovary	ARL17A	0.42	0.15	enet	5	0.16	9.6e-05	-9.10	-8.1	6.8e-16	0.87	0.00	0.99	FALSE
82	GTEx	Pancreas	ARL17B	0.26	0.05	enet	16	0.09	1.1e-04	-9.10	-5.4	6.2e-08	0.62	0.00	0.92	FALSE
83	GTEx	Pituitary	KANSL1	0.58	0.24	lasso	4	0.24	8.9e-07	-8.16	8.3	1.3e-16	-0.75	0.00	0.99	FALSE
84	GTEx	Pituitary	LRRC37A	0.66	0.17	lasso	22	0.45	7.5e-13	0.15	-6.6	4.6e-11	0.46	0.16	0.63	FALSE
85	GTEx	Pituitary	ARL17A	0.63	0.43	lasso	6	0.42	8.6e-12	-9.10	-9.6	5.6e-22	0.99	0.00	1.00	FALSE
86	GTEx	Pituitary	ARL17B	0.27	0.22	enet	6	0.21	4.7e-06	-9.10	-8.8	2.0e-18	0.87	0.00	0.98	FALSE
87	GTEx	Pituitary	NSFP1	0.52	0.36	lasso	5	0.36	5.6e-10	-9.10	-9.6	1.1e-21	0.96	0.00	1.00	FALSE
88	GTEx	Prostate	ARL17A	0.52	0.08	enet	14	0.21	5.1e-06	-2.92	-7.4	1.4e-13	0.60	0.01	0.61	FALSE
89	GTEx	Skin Not Sun Exposed Suprapubic	ARL17A	0.32	0.10	enet	8	0.12	3.5e-07	-9.10	-9.9	4.6e-23	0.85	0.00	1.00	FALSE
90	GTEx	Skin Not Sun Exposed Suprapubic	NSFP1	0.54	0.29	enet	17	0.37	1.8e-21	-9.10	-9.7	2.1e-22	0.83	0.00	1.00	FALSE
91	GTEx	Skin Sun Exposed Lower leg	KANSL1	0.39	0.11	enet	20	0.16	6.8e-13	-8.16	7.5	9.4e-14	-0.66	0.00	1.00	FALSE
92	GTEx	Skin Sun Exposed Lower leg	ARL17A	0.53	0.21	lasso	9	0.29	7.3e-24	-9.10	-9.9	2.7e-23	0.90	0.00	1.00	FALSE
93	GTEx	Skin Sun Exposed Lower leg	NSFP1	0.55	0.22	lasso	7	0.30	5.3e-25	-9.10	-9.7	3.8e-22	0.89	0.00	1.00	FALSE
94	GTEx	Spleen	NSFP1	0.41	0.02	enet	11	0.11	1.0e-03	-2.27	-5.3	9.4e-08	0.23	0.02	0.11	FALSE
95	GTEx	Stomach	ARL17A	0.42	0.17	lasso	5	0.24	5.8e-12	-8.51	-9.2	2.3e-20	0.76	0.02	0.98	FALSE
96	GTEx	Stomach	NSFP1	0.50	0.11	enet	46	0.18	4.9e-09	-9.10	-8.3	1.1e-16	0.54	0.00	0.99	FALSE
97	GTEx	Testis	KANSL1	0.19	0.05	enet	10	0.09	6.6e-05	0.64	6.5	1.1e-10	-0.26	0.01	0.12	FALSE
98	GTEx	Testis	LRRC37A	0.71	0.46	enet	10	0.55	5.7e-29	-9.10	-10.0	1.7e-23	0.85	0.00	1.00	FALSE
99	GTEx	Testis	ARL17A	0.60	0.28	enet	14	0.36	1.1e-16	-9.10	-9.5	1.5e-21	0.77	0.00	1.00	FALSE
100	GTEx	Testis	LRRC37A2	0.78	0.38	enet	47	0.54	3.0e-28	-9.10	-9.1	6.4e-20	0.71	0.00	1.00	FALSE
101	GTEx	Testis	NSFP1	0.66	0.09	lasso	10	0.38	1.0e-17	-3.03	-8.0	1.9e-15	0.48	0.14	0.82	FALSE
102	GTEx	Thyroid	KANSL1	0.26	0.02	enet	16	0.10	7.8e-08	1.36	5.3	1.2e-07	-0.23	0.07	0.34	FALSE
103	GTEx	Thyroid	ARL17A	0.48	0.19	lasso	7	0.24	2.2e-18	-9.10	-9.8	1.4e-22	0.84	0.00	1.00	FALSE
104	GTEx	Thyroid	NSFP1	0.42	0.17	enet	14	0.27	4.6e-21	-9.10	-9.8	1.3e-22	0.80	0.00	1.00	FALSE
105	GTEx	Whole Blood	NSFP1	0.25	0.05	enet	22	0.12	1.0e-10	-9.10	-9.2	5.8e-20	0.71	0.00	1.00	FALSE
106	METSIM	Adipose	ARL17B	0.34	0.08	bslmm	88	0.10	3.4e-15	-9.10	-8.0	1.8e-15	0.71	0.00	1.00	FALSE
107	METSIM	Adipose	LRRC37A	0.56	0.25	lasso	5	0.32	5.5e-49	-9.10	-10.0	1.7e-23	0.92	0.00	1.00	FALSE
108	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARL17A	0.14	0.00	enet	15	0.05	3.6e-05	-9.10	-5.8	6.7e-09	0.55	0.00	0.78	FALSE
109	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARL17A	0.18	0.05	lasso	8	0.11	3.0e-21	0.15	-6.4	1.8e-10	0.40	1.00	0.00	FALSE
110	The Cancer Genome Atlas	Colon Adenocarcinoma	ARL17A	0.35	0.00	lasso	6	0.09	4.4e-06	-2.09	-7.0	2.3e-12	0.34	0.10	0.33	FALSE
111	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARL17A	0.16	0.01	enet	8	0.05	3.2e-06	-8.51	-6.8	1.1e-11	0.39	0.04	0.20	FALSE
112	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL17A	0.20	0.02	lasso	2	0.07	9.7e-09	-8.51	-6.9	6.6e-12	0.46	0.02	0.74	FALSE
113	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ARL17A	0.13	0.02	lasso	3	0.07	2.8e-05	-8.51	-6.5	9.4e-11	0.51	0.02	0.55	FALSE
114	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRRC37A2	0.43	0.26	enet	22	0.37	3.8e-23	1.00	6.1	9.3e-10	-0.60	1.00	0.00	FALSE
115	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LRRC37A2	0.40	0.14	lasso	6	0.21	4.4e-08	-8.16	6.6	3.1e-11	-0.71	0.11	0.86	FALSE
116	The Cancer Genome Atlas	Thyroid Carcinoma	ARL17A	0.37	0.02	lasso	9	0.17	1.3e-16	0.62	-6.1	9.7e-10	0.39	0.80	0.20	FALSE
117	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1267	0.09	0.03	lasso	3	0.01	7.5e-02	-8.16	8.8	1.8e-18	-0.75	0.00	0.89	FALSE