Hub : Genes

NSF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.097 0.036 0.00015 0.009 0.04 0.037 0.038 0.018 2.4e-02 1.1e-05 2.2e-05 1.7e-05 0.00270
2 GTEx Cells EBV-transformed lymphocytes 0.200 0.082 0.00380 0.075 NA 0.092 NA 0.102 2.0e-03 NA 6.5e-04 NA 0.00034
3 GTEx Cells Transformed fibroblasts 0.059 0.028 0.00490 0.025 NA 0.022 NA 0.024 4.9e-03 NA 7.8e-03 NA 0.00570
4 GTEx Esophagus Muscularis 0.166 0.069 0.00044 0.005 NA 0.006 NA -0.003 1.5e-01 NA 1.4e-01 NA 0.50000
5 GTEx Prostate 0.195 0.076 0.00200 -0.011 NA -0.012 NA -0.010 7.3e-01 NA 9.7e-01 NA 0.70000
6 GTEx Testis 0.100 0.047 0.00200 0.095 NA 0.043 NA 0.065 5.3e-05 NA 5.3e-03 NA 0.00079

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 1.1 0.0 0.8 1.0 -0.7 0.0 1.1
Bipolar Disorder or Schizophrenia 0.7 1.6 2.7 -1.2 -0.4 -1.5 -1.0 1.4 -1.6
Depressed Affect (Nagel 2018) 23.2 48.7 82.1 3.5 6.6 8.0 -5.5 -7.7 9.1
Depression (Nagel 2018) 7.8 11.8 19.4 0.9 2.9 3.7 -3.7 -4.4 3.9
Intelligence (Savage-Jansen 2018) 6.4 19.7 36.7 -1.0 -6.1 -4.5 5.3 3.7 -4.4
Neuroticism (Nagel 2018) 28.8 67.7 103.7 3.5 8.4 9.0 -7.2 -9.2 10.2
Schizophrenia (2018) 2.0 4.2 9.0 -1.7 -1.3 -2.8 -0.7 1.8 -3.0
Schizophrenia vs Biploar Disorder 3.3 4.3 9.2 -2.3 -1.3 -2.8 0.2 1.4 -3.0
Worry (Nagel 2018) 16.9 35.6 48.6 2.8 6.2 6.5 -5.4 -7.0 6.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 0.2 -0.4 -0.8 0.6 -0.4 -0.2
Alzheimer’s Disease (in father) 0.4 0.5 1.4 -0.2 -0.5 -1.2 -0.3 0.4 -1.0
Alzheimer’s Disease (including proxy) 1.1 1.6 4.2 -0.7 -1.1 -2.0 0.4 0.7 -1.8
Crohns Disease (2017) 2.4 5.3 9.6 -0.7 -3.1 -2.7 1.8 2.3 -2.4
Irritable Bowel Disease (IBD) 1.3 3.1 5.2 -1.2 -2.0 -2.1 1.1 1.4 -2.3
Ulcerative Colitis (UC) 0.3 0.6 1.9 -1.0 -0.1 -0.8 0.1 0.2 -1.4
Major Depression (MDD) 1.5 1.8 7.9 2.8 -0.9 0.2 1.0 -0.7 0.8
Reaction Time 10.1 19.2 52.7 -1.8 6.9 1.4 -7.3 -3.0 0.9
Verbal and Numeric Reasoning (VNR) 4.2 10.0 13.7 -1.8 -3.6 -3.7 2.9 3.1 -3.4
Breast Cancer 8.8 21.2 33.1 2.1 4.0 4.9 -4.7 -5.8 5.2
Ovarian Cancer 18.1 23.9 44.6 -4.6 -3.7 -6.1 2.1 4.7 -6.7
Prostate Cancer 1.2 1.7 3.2 0.0 -1.5 -0.7 1.2 1.8 -1.7
Age at First Birth 1.2 1.7 4.0 -0.5 -1.1 -1.2 -0.1 1.7 -2.0
Bipolar Disorder (2011) 0.6 0.6 1.5 -0.2 0.0 0.9 -0.8 -0.7 1.2
Body Mass Index (BMI) (2010) 1.3 1.7 6.2 0.3 -0.2 1.0 -1.6 -2.5 0.7
Coronary Artery Disease (CAD) 1.9 2.2 6.7 2.6 0.1 1.7 1.1 -0.2 1.6
Crohns Disease (2012) 4.1 6.5 11.9 -1.8 -2.6 -3.4 1.3 2.0 -3.5
Mean Putamen Volume 9.2 10.5 19.7 1.0 3.0 4.4 -2.7 -3.3 3.8
Fasting Glucose 1.4 1.6 4.2 0.2 -1.1 -2.0 0.6 1.2 -1.6
HbA1C 0.2 0.3 0.6 0.6 -0.5 0.6 -0.2 -0.4 0.7
HDL Cholesterol 1.8 3.0 11.0 3.3 -0.8 -0.1 2.4 0.9 0.4
LDL Cholesterol 2.9 4.6 7.7 2.8 2.3 1.8 -0.8 -1.8 2.7
Lupus 4.8 7.3 10.4 0.7 -3.0 -3.2 2.6 3.0 -2.9
Neuroticism (2016) 10.7 15.4 20.3 2.1 4.4 4.0 -3.6 -4.5 4.5
Primary Biliary Cirrhosis 9.5 13.6 18.0 -3.5 -3.6 -4.2 2.9 3.5 -4.2
Rheumatoid Arthritis 1.4 2.0 3.9 0.9 1.9 1.1 -2.0 -1.0 1.1
Schizophrenia (2014) 2.9 6.4 12.0 -2.9 -1.1 -3.2 -1.0 2.3 -3.5
Triglycerides 1.1 1.7 2.8 -0.8 -1.7 -1.4 1.4 1.2 -1.3
Type 2 Diabetes (T2D) (2012) 1.9 2.2 3.8 -0.9 -1.6 -1.1 1.9 1.9 -1.1
Ulcerative Colitis 0.4 0.6 1.9 -1.4 -0.2 -0.7 -0.1 0.1 -1.1
Blood Eosinophil Count 9.8 75.2 141.6 -2.0 -7.2 -10.5 7.2 9.5 -11.9
Blood Platelet Count 0.9 10.5 24.6 5.0 -0.9 2.9 3.0 -0.9 4.4
Blood Red Count 24.6 237.3 449.4 13.8 11.7 19.2 -6.9 -15.2 21.2
Blood White Count 1.1 8.1 15.8 2.5 1.7 3.2 -1.1 -3.4 4.0
Heel T-Score 6.7 53.1 86.9 -2.5 -7.7 -8.4 5.7 8.0 -9.3
BMI 0.2 0.9 2.8 0.5 -0.7 0.3 0.1 -1.7 1.4
Height 4.1 80.0 148.8 -6.1 -12.2 -9.1 7.3 7.6 -10.0
Waist Hip Ratio (WHR) 7.9 35.4 80.1 5.4 3.2 8.1 -1.8 -5.0 8.9
Systolic Blood Pressure 8.1 40.3 80.8 0.7 -6.6 -5.0 8.5 9.0 -4.5
Smoking Status 4.8 11.4 19.2 -0.5 -4.4 -3.9 3.4 2.7 -3.8
Allergy or Eczema 0.6 1.5 2.8 -1.5 -1.1 -1.7 0.1 0.4 -1.5
Cardiovascular Disease 2.6 8.5 23.1 1.3 -3.0 -1.3 4.8 3.8 -0.8
Hypothyroidism (self reported) 0.8 1.8 4.8 -0.8 0.3 1.3 -0.2 -2.2 1.9
Respiratory disease 0.4 0.8 2.3 0.6 -0.7 -1.1 1.5 0.5 -0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.8 -0.6 0.2 -0.8 -0.0 0.8
Lung FEV1/FVC ratio 2.9 14.6 25.3 -3.6 -1.7 -5.0 1.5 4.9 -4.4
Lung FVC 26.1 132.9 213.2 -3.2 -13.2 -12.5 10.0 12.0 -14.6
Neuroticism 26.8 64.6 102.0 3.6 7.9 9.3 -6.5 -9.0 10.1
Chronotype (morning person) 1.5 3.6 13.9 3.7 -0.5 1.3 1.1 -1.4 1.5
Hair Pigment 0.4 11.8 25.0 -4.4 -0.6 -4.3 -0.0 2.7 -5.0
Tanning 0.5 6.2 12.6 -1.7 -1.7 -2.7 1.7 3.0 -3.5
Hand grip strength (left) 10.7 28.2 46.8 -2.5 -5.8 -5.9 4.6 5.3 -6.8
Number of treatments/medications taken 0.4 0.6 1.8 0.9 -0.2 0.3 1.0 -0.3 1.4
Average weekly spirits intake 0.6 0.8 2.2 0.7 -1.4 -0.1 1.5 0.3 0.3
Sensitivity / hurt feelings 27.8 47.6 73.9 2.9 7.0 7.7 -6.1 -7.6 8.6
Frequency of depressed mood in last 2 weeks 8.8 12.3 17.1 1.1 3.4 4.0 -3.4 -4.1 4.1
Hearing difficulty/problems: Yes 4.4 6.7 18.3 -0.1 4.3 1.8 -3.3 -1.8 2.3
Relative age of first facial hair 32.9 67.7 110.2 4.4 7.4 10.5 -6.3 -8.6 10.4
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 6.4 -0.5 1.3 1.0 -1.9 -2.5 1.5
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.7 -0.4 0.6 -0.0 -0.8 -0.2 0.1
Ever had hysterectomy (womb removed) 0.8 0.9 1.6 1.0 0.7 1.2 -0.8 -0.5 1.1
Systolic blood pressure, automated reading 10.3 30.0 55.0 -1.3 -5.4 -5.4 6.6 7.4 -4.7
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 6.2 -2.5 0.2 -0.6 -0.4 1.9 -0.5
Angina 0.3 0.4 2.0 -0.3 0.0 0.2 0.6 1.4 0.1
Medication for hormone replacement therapy 1.4 1.5 4.9 -0.6 -1.3 -1.4 -0.3 0.3 -2.2
Vitamin and mineral supplements 6.5 8.8 16.0 -2.6 -1.3 -3.6 1.3 4.0 -3.7
Supplements: Zinc 3.6 4.0 5.8 2.3 1.3 2.2 -1.2 -2.2 2.4
Medication: Co-codamol 0.2 0.2 0.4 0.3 -0.4 -0.2 0.5 -0.6 0.6
Medication: Metformin 0.2 0.2 0.6 -0.2 -0.6 0.3 0.1 0.8 0.6
Diabetes (father) 1.3 1.6 5.2 0.2 1.2 1.3 -0.1 -1.1 2.3
Diabetes (mother) 0.3 0.4 1.2 -0.1 -1.1 -0.1 0.0 1.0 -0.2
Severe depression (siblings) 3.1 3.5 6.1 0.9 1.6 2.2 -1.1 -2.4 2.5
Pack years adult smoking proportion 0.6 0.9 2.2 1.5 -1.1 0.0 1.1 0.2 0.8
Impedance of leg (right) 2.6 12.6 24.5 -1.9 -2.5 -4.0 2.9 5.0 -4.0
Leg fat-free mass (left) 0.6 3.0 12.5 -0.8 -3.5 -0.4 2.1 -0.1 -0.3
Trunk fat percentage 8.5 34.0 48.5 -2.6 -7.0 -6.2 6.2 6.5 -5.6
Hand grip strength (right) 8.5 23.0 35.8 -2.6 -5.6 -5.0 4.2 4.7 -6.0
Townsend deprivation index at recruitment 0.4 0.6 2.3 1.5 0.2 -0.1 0.3 -1.0 0.4
Current tobacco smoking 1.9 3.1 5.5 0.6 -2.0 -2.3 2.3 1.2 -1.6
Average weekly fortified wine intake 3.5 4.1 9.6 -3.1 0.5 -2.8 -0.2 1.3 -2.4
Maternal smoking around birth 0.5 0.7 1.8 1.2 -1.3 -0.1 0.9 -0.1 -0.1
Fed-up feelings 11.1 20.2 38.6 4.3 3.5 5.2 -1.9 -4.6 6.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 11.0 1.3 1.4 1.9 -1.6 -3.3 2.0
Relative age voice broke 21.1 32.2 53.7 3.7 4.6 7.3 -4.0 -6.0 7.3
Taking other prescription medications 0.0 0.0 0.1 -0.2 -0.1 0.0 0.1 -0.2 0.4
Age when periods started (menarche) 2.6 6.2 12.3 0.8 2.4 3.0 -1.6 -2.6 3.5
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.3 1.1 1.5 0.8 -0.9 -0.9 1.1
Heel bone mineral density (BMD) T-score, automated (left) 2.8 6.4 9.6 -1.7 -2.3 -2.6 2.2 3.1 -3.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 0.2 0.2 -0.6 1.1 0.6 -0.2
Qualifications: CSEs or equivalent 7.0 9.2 17.0 3.4 1.3 4.1 -1.2 -2.7 4.0
Serious illness, injury or assault to yourself 0.9 1.1 2.8 -0.3 1.7 1.1 -1.0 -0.2 1.1
High blood pressure 5.1 14.2 25.4 -0.9 -3.7 -3.8 4.2 5.0 -3.7
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 -0.1 -0.7 -0.8 0.0 0.0 -0.8
Multivitamins +/- minerals 2.8 3.6 6.1 2.2 0.3 2.3 0.0 -2.5 2.3
Stomach or abdominal pain in last month 1.3 1.6 2.7 1.2 1.2 1.1 -1.3 -1.0 1.6
Supplements: Glucosamine 0.2 0.2 0.6 -0.8 -0.7 0.1 0.3 0.1 0.1
Diverticular disease/diverticulitis (self-reported) 5.5 6.5 11.2 -1.3 -2.5 -3.0 1.4 2.9 -3.3
Medication: Atenolol 3.0 3.7 7.2 -1.7 -2.1 -1.9 1.3 2.7 -1.6
Medication: Levothyroxine sodium 1.5 2.5 5.2 -0.9 1.2 1.9 -1.0 -1.8 2.3
Sitting height 9.8 69.4 100.0 -7.6 -9.2 -8.8 6.0 7.8 -10.0
Chronic bronchitis/emphysema (father) 0.6 0.7 3.7 -1.9 0.3 -0.3 -0.5 0.5 -0.3
High blood pressure (mother) 1.6 2.2 4.5 0.4 -1.6 -2.1 1.1 1.2 -1.8
Body mass index (BMI) 0.0 0.2 0.5 -0.2 -0.6 -0.4 0.7 -0.0 0.4
Impedance of leg (left) 2.8 13.7 26.1 -1.8 -2.4 -4.4 2.7 5.1 -4.5
Leg predicted mass (left) 0.6 3.2 13.1 -0.8 -3.6 -0.5 2.2 0.0 -0.3
Trunk fat mass 6.0 25.6 42.8 -2.4 -6.5 -5.2 5.5 5.1 -4.6
Waist circumference 0.3 1.2 2.6 0.4 -1.6 0.7 1.2 -0.4 1.6
Number of incorrect matches in round 5.0 8.2 12.6 0.4 3.6 2.8 -3.4 -3.5 2.3
Past tobacco smoking 3.7 6.7 11.0 1.5 3.1 2.8 -2.2 -2.2 3.3
Alcohol usually taken with meals 1.2 2.0 6.1 -2.5 -1.0 -1.3 -0.3 -0.1 -1.7
Nervous feelings 14.9 27.8 36.7 3.0 5.4 5.5 -5.1 -6.1 5.9
Frequency of tenseness / restlessness in last 2 weeks 19.5 30.4 45.2 3.0 5.8 5.5 -4.7 -6.7 6.5
Hearing difficulty/problems with background noise 8.1 12.9 18.2 1.7 4.3 3.3 -3.8 -4.1 3.9
Hair/balding pattern: Pattern 2 17.1 21.7 37.6 3.3 3.5 5.9 -3.2 -4.8 6.1
Had menopause 0.5 0.6 1.3 -1.1 0.6 -0.7 -1.1 -0.3 -0.6
Had other major operations 0.1 0.1 0.1 -0.1 0.4 0.4 -0.3 0.2 0.3
Forced vital capacity (FVC) 27.2 104.8 166.4 -3.1 -12.9 -10.1 10.4 10.5 -11.5
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.0 8.4 -1.0 -1.9 -2.4 2.2 2.9 -2.6
Ever unenthusiastic/disinterested for a whole week 10.2 12.5 20.5 2.8 2.8 4.5 -2.3 -3.8 4.4
Qualifications: None of the above 3.2 6.8 19.8 0.7 4.4 1.7 -2.8 -2.4 2.1
Financial difficulties in last 2 years 3.7 5.0 9.0 2.4 1.7 2.3 -0.5 -2.6 3.0
Mouth/teeth dental problems 5.1 7.9 15.9 1.0 -4.0 -2.8 3.3 1.2 -3.3
Heart attack 0.6 0.8 1.6 -1.3 1.1 0.7 -1.2 -0.2 0.6
Allergy 0.0 0.1 0.3 -0.2 0.3 0.3 0.3 0.6 0.1
Pain all over the body in last month 0.3 0.4 0.8 0.6 0.9 -0.4 0.3 -0.8 0.5
Diabetes (self-reported) 0.4 0.6 1.7 -1.0 -0.5 -0.5 -0.6 1.3 -0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.5 -0.2 0.2 0.3 -1.2 -0.1 0.3
Medication: Ramipril 0.5 0.7 1.3 -1.0 -1.1 -0.5 0.8 0.8 -0.6
Medication: Simvastatin 0.4 0.6 1.8 -1.1 -0.3 -0.1 0.7 1.4 -0.1
Fluid intelligence score 4.6 9.7 14.8 -1.7 -3.0 -3.9 3.3 3.1 -3.2
Illnesses of siblings 1.7 2.4 8.8 3.0 -0.8 0.4 1.1 -1.7 0.9
Neuroticism score 22.5 47.0 75.1 3.6 6.7 7.8 -5.5 -7.6 8.7
Weight 1.4 7.1 17.4 -1.6 -4.2 -2.4 3.2 1.8 -1.8
Impedance of arm (right) 8.7 40.5 60.3 -1.1 -7.3 -5.8 7.5 7.8 -6.2
Arm fat percentage (right) 2.7 10.7 21.7 0.1 -4.4 -2.8 4.7 3.3 -2.1
Trunk fat-free mass 0.3 1.4 4.7 -0.5 -1.4 0.9 -0.0 -2.2 0.9
Hip circumference 1.8 7.7 11.6 -2.4 -3.4 -3.3 2.6 2.0 -2.6
Time employed in main current job 8.0 9.2 19.4 -1.2 -2.5 -3.7 2.3 3.1 -4.4
Alcohol intake versus 10 years previously 0.3 0.4 1.2 0.4 -0.3 -0.4 1.1 0.8 -0.0
Father’s age at death 0.6 0.8 1.7 -0.7 -0.7 -1.3 0.3 -0.0 -1.3
Worrier / anxious feelings 12.1 22.9 31.3 1.8 5.1 4.9 -4.9 -5.6 5.3
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 12.2 1.2 1.9 1.8 -1.7 -3.5 3.0
Falls in the last year 4.2 5.7 7.9 -0.1 2.4 2.5 -2.6 -2.7 2.8
Hair/balding pattern: Pattern 3 32.6 48.5 95.3 -3.7 -6.5 -8.5 4.6 6.8 -9.8
Number of live births 8.1 11.4 19.4 2.8 2.9 4.1 -1.7 -3.6 4.4
Forced expiratory volume in 1-second (FEV1) 27.2 91.7 134.6 -3.4 -11.6 -9.8 9.4 10.1 -10.9
Pulse rate 1.3 2.2 5.7 -2.4 0.9 -1.0 -1.9 -0.3 -1.3
Happiness 1.0 1.3 3.3 1.3 0.9 1.1 0.4 -0.7 1.8
Noisy workplace 3.6 4.4 8.1 1.3 2.2 2.4 -1.5 -2.0 2.8
Qualifications: A levels/AS levels or equivalent 6.4 14.3 21.7 -3.7 -4.7 -3.1 3.6 3.9 -3.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 0.7 -0.0 -0.5 0.5 0.6 -0.2
Mouth/teeth dental problems: Dentures 1.3 2.1 6.8 -2.6 1.1 -1.6 -1.0 0.5 -0.9
Asthma 0.4 0.8 1.7 1.3 -0.4 -1.1 1.0 0.7 -0.6
Medication: Ibuprofen (e.g. Nurofen) 7.5 9.5 15.7 3.4 2.5 2.7 -1.5 -4.0 3.7
Medication: Cholesterol lowering 0.5 0.7 1.7 0.5 -1.0 -0.1 1.3 1.2 0.2
Depression (self-reported) 2.4 2.9 4.4 1.6 2.0 1.2 -1.4 -2.1 1.6
Medication: Lansoprazole 1.7 2.0 3.8 -0.7 -1.0 -1.7 0.3 1.9 -1.9
Prospective memory result 2.7 3.3 5.3 1.2 1.1 2.3 -2.2 -1.8 1.9
Lung cancer (father) 0.4 0.4 1.7 -1.3 -0.2 0.2 -0.6 0.6 -0.2
Illnesses of mother 0.6 0.8 1.8 -0.9 -0.4 -0.8 1.3 0.8 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 25.2 80.5 114.5 -3.3 -10.7 -9.4 9.2 9.1 -10.1
Pulse wave Arterial Stiffness index 1.3 1.5 4.1 -2.0 -0.5 -1.6 0.4 0.5 -1.1
Impedance of arm (left) 9.3 43.0 68.1 -2.0 -7.3 -6.0 7.3 8.3 -6.6
Arm fat mass (right) 1.8 7.4 16.0 -0.6 -4.0 -2.4 3.6 2.4 -1.8
Trunk predicted mass 0.2 1.4 4.7 -0.5 -1.4 0.9 -0.1 -2.2 0.9
Standing height 3.5 34.3 72.2 -3.9 -8.5 -5.0 6.0 4.9 -5.7
Length of working week for main job 0.5 0.5 1.4 0.1 -0.8 -1.2 0.2 0.4 -1.0
Exposure to tobacco smoke at home 1.4 1.5 4.6 -0.3 1.9 0.5 -2.1 -0.7 0.3
Breastfed as a baby 0.2 0.3 0.7 -0.5 0.0 -0.8 0.1 0.1 -0.8
Tense / ‘highly strung’ 4.8 7.9 12.7 1.6 2.7 3.1 -2.1 -3.6 3.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 10.5 3.2 -0.6 0.7 1.1 -0.2 1.1
Hair/balding pattern: Pattern 4 68.1 164.9 259.2 -7.9 -11.3 -15.3 10.2 14.2 -16.1
Birth weight of first child 2.1 3.7 8.2 -1.1 -2.9 -2.2 1.7 0.9 -2.1
Peak expiratory flow (PEF) 13.8 32.0 49.3 -3.0 -5.8 -6.5 4.6 6.0 -7.0
Pulse wave reflection index 0.2 0.2 0.9 -0.1 -0.0 0.2 0.3 -0.6 0.9
Ever highly irritable/argumentative for 2 days 2.7 3.2 6.5 1.2 2.0 1.6 -1.2 -1.8 2.5
Loud music exposure frequency 1.6 1.7 4.3 1.8 -2.1 -0.5 1.4 -0.2 -0.8
Qualifications: O levels/GCSEs or equivalent 3.2 5.0 9.0 -1.9 -3.0 -1.5 2.4 2.0 -2.3
Mouth/teeth dental problems: Bleeding gums 3.6 4.7 7.7 0.3 2.8 2.6 -2.3 -1.4 2.5
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.4 -0.2 0.8 0.4 -1.0 0.6
Medication: Paracetamol 13.6 22.5 45.7 4.7 3.9 5.0 -1.9 -4.8 6.8
Headache pain in last month 20.5 35.2 63.9 3.7 4.7 7.2 -4.1 -6.5 8.0
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 5.6 -0.5 2.1 1.4 -2.3 -2.4 0.9
Glaucoma (self-reported) 3.5 4.1 7.5 0.4 2.0 2.7 -2.2 -1.6 2.4
Gout (self-reported) 1.3 1.8 4.9 -0.2 0.1 -2.2 0.0 1.1 -2.1
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 6.2 -0.6 1.3 1.7 -0.9 -2.5 2.3
Medication: Amlodipine 3.5 4.9 8.3 -0.5 -2.1 -2.9 2.5 2.0 -2.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.5 -0.6 -0.3 -1.6 0.6 1.3 -1.2
Birth weight 0.5 1.1 3.5 0.5 -1.9 -0.4 1.6 0.3 -0.1
Chronic bronchitis/emphysema (mother) 3.6 4.2 8.4 1.3 2.9 2.1 -1.6 -1.9 2.1
High blood pressure (siblings) 3.7 5.3 11.1 -2.1 -1.4 -2.3 1.0 3.3 -2.8
Forced vital capacity (FVC), Best measure 26.7 97.7 151.3 -3.2 -12.3 -10.1 10.2 9.8 -11.1
Body fat percentage 5.2 20.4 27.9 -2.1 -5.3 -4.9 4.9 5.1 -4.1
Leg fat percentage (right) 1.1 4.1 7.8 -1.0 -1.9 -2.8 1.9 2.3 -1.8
Arm fat-free mass (right) 0.2 0.9 2.0 -1.4 -1.3 -0.1 -0.4 -1.4 0.1
Exposure to tobacco smoke outside home 4.0 5.4 10.5 -0.6 2.3 2.7 -2.3 -1.8 3.2
Comparative body size at age 10 2.3 6.3 19.1 4.4 -1.5 1.9 1.0 -2.5 2.4
Number of full brothers 8.0 10.1 17.6 0.3 4.2 4.0 -2.9 -2.4 3.6
Worry too long after embarrassment 6.4 10.7 17.2 0.6 3.7 3.4 -3.2 -3.4 4.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.3 1.1 -0.4 0.4 -0.2 -1.0 0.6
Wheeze or whistling in the chest in last year 2.2 3.8 6.4 1.3 2.5 1.8 -1.9 -1.9 2.3
Number of children fathered 1.1 1.3 2.5 -1.5 1.6 0.5 -1.4 -0.4 0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 3.4 0.4 1.9 0.4 -1.7 -1.8 0.7
Age at first live birth 6.0 10.7 17.9 -1.2 -4.2 -3.4 3.1 3.5 -3.4
Pulse wave peak to peak time 0.6 0.7 2.6 1.6 -0.3 1.2 0.2 0.1 0.6
Health satisfaction 0.4 0.6 2.1 1.4 0.1 0.3 0.7 -0.3 0.9
Shortness of breath walking on level ground 0.6 0.7 1.8 0.6 0.4 0.7 0.2 -1.2 1.3
Qualifications: College or University degree 10.2 32.3 44.5 -4.5 -6.7 -5.9 4.3 5.9 -6.4
Eye problems/disorders: None of the above 1.5 1.7 4.3 0.3 -1.3 -1.5 2.1 0.6 -1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.7 -0.1 0.2 -0.8 0.4 0.6 -0.6
Emphysema/chronic bronchitis 5.7 6.4 11.4 0.7 2.8 2.4 -2.7 -2.3 3.4
Medication for pain relief, constipation, heartburn 7.7 13.1 25.8 -3.0 -3.4 -3.8 1.9 3.7 -5.1
Neck or shoulder pain in last month 1.6 2.2 4.7 -1.5 -0.1 -2.2 0.0 1.5 -2.0
Medication: Blood pressure 2.0 3.5 5.7 0.2 -2.2 -1.9 2.0 2.4 -1.5
Angina (self-reported) 0.3 0.4 1.5 -0.5 -0.2 0.3 0.5 1.2 0.2
Migraine (self-reported) 1.3 1.6 3.3 -0.0 1.1 1.8 -0.8 -1.2 1.7
Medication: Ibuprofen 5.6 6.7 11.1 2.5 2.3 2.2 -1.3 -3.3 3.3
Medication: Allopurinol 1.4 1.8 3.5 1.2 -0.4 -1.9 1.1 1.3 -1.7
Medication: Omeprazole 1.4 1.6 5.4 -2.3 -0.6 -1.0 0.6 1.0 -1.2
Medication: Seretide 50 evohaler 1.4 1.6 3.3 1.8 -1.6 -1.0 1.1 0.7 -1.1
Mean time to correctly identify matches 9.8 18.7 53.4 -3.1 6.6 0.4 -7.3 -2.5 -0.1
Heart disease (mother) 3.8 4.7 7.2 1.3 2.1 2.2 -1.8 -2.7 2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 6.3 7.5 12.8 -0.4 3.6 2.5 -3.1 -2.8 2.8
Whole body fat mass 3.6 14.9 26.3 -1.9 -5.1 -4.0 4.3 3.8 -3.3
Leg fat mass (right) 1.5 5.6 9.0 -1.4 -3.0 -2.7 2.6 2.3 -1.9
Arm predicted mass (right) 0.2 1.0 3.1 -1.1 -1.1 0.4 -0.6 -1.8 0.5
Pulse rate, automated reading 1.4 4.7 15.8 -4.0 -0.3 -2.3 -1.8 0.9 -1.8
Alcohol intake frequency. 9.6 22.4 39.8 2.7 3.5 6.2 -3.5 -4.9 6.3
Comparative height size at age 10 4.2 22.9 32.6 -2.5 -5.7 -5.0 4.7 4.7 -5.4
Number of full sisters 0.5 0.6 1.4 0.6 0.7 1.2 0.2 -0.5 1.2
Suffer from ‘nerves’ 7.3 11.5 17.7 0.2 3.9 3.5 -3.5 -4.2 3.4
Overall health rating 0.2 0.4 1.3 0.4 0.6 0.2 -0.5 0.2 1.1
Chest pain or discomfort 1.5 2.1 4.0 -1.7 -0.9 -1.8 0.9 2.0 -1.1
Had major operations 1.1 1.3 2.7 -1.0 1.6 0.3 -1.6 -0.7 1.1
Age at last live birth 6.1 8.8 19.7 -0.4 -4.4 -2.7 3.5 2.8 -2.3
Family relationship satisfaction 0.1 0.2 0.6 -0.1 0.4 0.4 -0.1 -0.2 0.8
Leg pain on walking 5.3 6.7 10.7 1.3 3.1 2.9 -2.0 -2.4 3.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.7 1.1 0.4 1.2 0.9 0.0 1.6
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.5 -0.1 1.3 1.5 -1.7 -0.8 1.9
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 5.2 -0.1 -1.7 -2.0 1.2 0.9 -2.3
Medication: Aspirin 0.3 0.4 1.1 0.2 0.8 0.6 -0.4 -0.4 1.1
Supplements: Vitamin C 9.0 10.6 18.7 2.4 2.1 3.9 -1.9 -4.3 4.0
Knee pain experienced in last month 0.2 0.3 0.6 0.8 0.6 -0.1 -0.4 -0.5 0.4
Hypertension (Self-reported) 4.7 13.0 23.2 -0.8 -3.5 -3.8 3.9 4.8 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 5.8 -1.1 -1.2 -2.4 1.7 2.2 -2.2
Illnesses of father: Heart disease 4.1 5.7 12.7 0.2 2.7 3.2 -1.6 -0.9 3.6
Illnesses of siblings: Diabetes 0.3 0.3 1.2 -0.5 0.5 0.5 -0.2 -0.2 1.1
Smoking status: Previous 3.7 5.5 9.3 -1.0 -2.6 -2.6 2.0 2.3 -3.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.0 -0.3 -1.7 -0.7 1.0 0.3 -0.8
Whole body fat-free mass 0.2 1.4 5.3 -0.9 -2.3 0.2 0.7 -1.3 0.4
Leg fat-free mass (right) 0.5 2.6 11.6 -0.7 -3.4 -0.3 1.9 -0.2 -0.2
Arm fat percentage (left) 2.9 11.7 20.5 -0.4 -4.5 -3.1 4.4 3.7 -2.5
Average weekly red wine intake 1.7 2.5 5.7 -2.2 0.1 -1.7 -1.2 0.1 -2.4
Handedness (chirality/laterality): Left-handed 17.8 21.3 30.4 -0.5 -5.1 -4.7 5.2 4.7 -5.5
Mood swings 20.1 36.3 58.6 2.7 6.1 6.9 -4.8 -6.6 7.7
Loneliness, isolation 7.8 10.8 18.5 1.2 3.1 4.2 -2.5 -3.4 4.3
Long-standing illness, disability or infirmity 0.4 0.7 1.5 0.4 1.2 0.4 -0.9 -0.5 1.0
Ever had bowel cancer screening 5.0 5.8 10.6 -1.4 -1.7 -3.3 1.5 2.6 -3.2
Diabetes diagnosed by doctor 0.6 1.0 2.9 -1.4 -0.7 -0.8 -0.1 1.7 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.7 -0.1 -0.2 -0.1 0.8 0.3 0.2
Friendships satisfaction 0.8 1.0 2.4 1.0 0.1 1.2 0.9 -0.6 1.6
Qualifications: nursing, teaching 3.2 5.0 8.2 -1.6 -2.4 -2.1 1.4 2.7 -2.9
Commuting to job workplace: Walk 0.1 0.1 0.3 0.4 0.3 0.2 0.2 0.6 -0.1
Eye problems/disorders: Cataract 1.5 1.8 4.4 -0.1 2.1 1.1 -1.4 -1.1 1.3
Mouth/teeth dental problems: Mouth ulcers 12.3 19.5 39.7 3.2 3.7 5.9 -2.8 -3.4 6.3
Medication for cholesterol 4.7 7.1 12.0 1.2 2.6 2.9 -2.0 -3.5 3.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 -0.5 -0.3 -0.7 -0.2 -0.4 -0.9
Back pain experienced in last month 0.7 1.0 2.1 -1.5 1.0 -1.2 -0.9 0.5 -0.8
Mineral and other dietary supplements 0.9 1.2 2.3 -0.1 -0.7 -1.4 0.9 1.5 -1.2
Breast cancer (self-reported) 3.7 4.5 7.7 -2.2 -0.7 -2.8 0.9 2.4 -2.7
Asthma (self-reported) 0.3 0.6 1.6 1.3 -0.3 -0.9 0.8 0.5 -0.5
Osteoporosis (self-reported) 3.2 4.0 6.3 1.4 2.5 1.9 -1.6 -2.1 2.2
Osteoarthritis (self-reported) 0.4 0.5 1.4 -1.2 -0.0 -0.9 0.2 0.4 -0.7
Medication: Aspirin 0.3 0.4 0.9 -0.3 0.9 0.3 -0.5 -0.4 0.9
Medication: Gliclazide 0.4 0.4 1.0 0.5 -0.8 0.7 0.4 -0.3 1.0
Illnesses of father: None of the above (group 1) 3.4 4.2 7.2 -0.0 -2.4 -2.4 1.8 1.8 -2.7
Smoking status: Current 1.8 2.9 4.9 0.4 -1.9 -2.2 2.2 1.2 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 22.6 47.7 68.9 -3.5 -6.7 -8.0 6.0 7.7 -8.3
Whole body water mass 0.2 1.3 4.6 -0.8 -2.1 0.4 0.6 -1.4 0.5
Leg predicted mass (right) 0.5 2.4 10.8 -0.7 -3.3 -0.3 1.8 -0.3 -0.2
Arm fat mass (left) 1.8 7.4 16.3 -0.9 -4.0 -2.3 3.5 2.6 -1.8
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.1 -0.3 0.1 0.6 0.4 0.6
Average weekly champagne plus white wine intake 11.5 15.8 20.0 -4.4 -3.7 -4.2 2.6 4.0 -4.5
Miserableness 11.7 20.2 33.5 2.5 4.4 5.0 -3.2 -5.2 5.8
Guilty feelings 7.6 11.4 19.8 2.2 3.2 3.9 -2.5 -3.6 4.4
Wears glasses or contact lenses 0.5 0.6 1.8 -0.8 -0.1 0.4 -1.3 -1.0 0.3
Ever taken oral contraceptive pill 2.3 2.5 6.4 0.4 0.7 1.6 -1.2 -2.5 2.0
Hearing aid user 0.8 0.9 3.4 0.7 0.4 1.1 -0.1 0.1 1.9
Mother’s age at death 0.6 0.8 3.5 -1.9 0.2 -0.0 -0.8 -0.2 -0.5
Financial situation satisfaction 0.8 1.0 1.8 1.4 -0.7 1.0 1.3 -0.4 0.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 -0.8 1.1 0.1 -1.1 -0.2 0.7
Commuting to job workplace: Public transport 1.9 2.2 5.5 -0.4 -1.0 -2.3 0.6 1.0 -2.3
Eye problems/disorders: Glaucoma 5.0 5.9 11.4 0.3 2.4 3.4 -2.5 -1.9 2.8
Medication: Blood pressure 8.3 15.8 28.5 -2.1 -4.0 -3.9 3.5 5.3 -4.2
Pain type(s) experienced in last month: Hip pain 3.0 3.8 5.8 0.7 2.4 2.1 -2.1 -2.0 1.9
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.7 0.8 0.4 0.8 -0.2 -1.3 0.8
High cholesterol (Self-reported) 2.3 4.0 10.5 -1.2 -1.5 -1.9 2.0 3.2 -1.6
Medication: Bendroflumethiazide 3.5 5.4 10.7 -0.2 -2.1 -2.2 3.3 2.8 -2.1
Medication: Paracetamol 14.1 21.8 42.2 3.8 4.4 4.9 -2.6 -4.9 6.5
Medication: Lisinopril 2.9 3.7 7.3 0.7 -2.7 -0.9 2.1 2.5 -1.6
Medication: Atorvastatin 0.6 0.8 3.6 0.0 0.0 -0.8 0.8 1.9 0.0
Illnesses of father: High blood pressure 1.3 1.6 2.7 0.3 -1.3 -1.3 1.6 1.1 -1.4
Alcohol drinker status: Never 2.2 2.6 4.3 0.6 1.4 1.8 -1.6 -1.8 2.1
Ever smoked 2.3 4.1 7.6 -0.4 -2.4 -2.3 2.0 1.3 -2.8
Basal metabolic rate 0.3 1.9 8.2 -0.8 -2.9 -0.2 1.4 -0.6 -0.0
Leg fat percentage (left) 1.2 4.4 9.0 -0.9 -1.8 -3.0 1.7 2.4 -2.1
Arm fat-free mass (left) 0.2 0.8 2.3 -0.7 -1.5 0.1 0.1 -1.3 0.3
Number of operations (self-reported) 1.6 2.4 3.9 0.0 1.3 1.4 -1.8 -1.8 2.0
Average weekly beer plus cider intake 2.1 3.0 5.5 0.2 -0.8 -2.3 1.2 2.3 -2.3
Irritability 10.3 17.5 33.6 2.8 3.6 5.1 -2.4 -4.4 5.8
Risk taking 1.5 2.2 4.7 1.3 1.5 1.5 -0.7 -2.2 1.3
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.9 0.5 -1.7 -0.5 1.3 -0.9 -0.5
Fractured/broken bones in last 5 years 9.1 11.7 15.8 1.7 3.8 4.0 -3.0 -3.6 3.8
Age started oral contraceptive pill 1.8 2.2 4.2 -1.3 -0.1 -2.0 0.9 2.1 -1.7
Diastolic blood pressure, automated reading 2.9 9.1 15.3 -2.6 -2.4 -3.4 3.0 3.9 -2.6
Ever depressed for a whole week 4.5 5.6 13.1 1.4 2.1 3.1 -1.2 -1.6 3.6
Unable to work because of sickness or disability 0.6 0.8 2.3 1.4 -0.1 0.0 -0.2 -1.5 0.6
Commuting to job workplace: Cycle 0.9 1.1 3.5 -1.9 -1.1 0.4 0.9 1.0 -0.2
Myopia 5.5 7.9 16.5 -0.8 -2.4 -4.1 1.4 2.9 -3.8
Vascular/heart problems diagnosed by doctor 4.0 10.9 21.4 1.0 3.3 3.1 -3.6 -4.6 3.0
Cholesterol lowering medication 1.5 2.3 5.4 -1.8 -0.5 -1.6 0.7 2.3 -1.4
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 6.6 -2.6 -0.7 -1.2 0.5 1.6 -1.4
Pain experienced in last month 5.1 8.6 16.5 -0.6 -4.1 -2.4 3.2 3.0 -3.2
Supplements: Calcium 0.3 0.3 0.5 0.1 -0.6 0.5 0.2 -0.7 0.7
Basal cell carcinoma (self-reported) 0.2 0.2 0.8 -0.9 0.4 0.1 -0.1 0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.6 -1.3 0.9 0.5 -0.8 0.1 0.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.6 0.5 -0.6 0.6 0.6 -0.8 0.2
Heart disease (siblings) 6.3 7.8 11.8 1.7 3.3 3.4 -2.6 -2.2 3.1
Alcohol drinker status: Previous 0.4 0.5 2.2 -1.5 -0.4 0.3 -0.5 0.1 -0.1
Pack years of smoking 0.3 0.5 1.2 0.9 -1.1 0.1 0.7 -0.0 0.8
Impedance of whole body 7.4 37.6 62.6 -2.3 -6.2 -6.2 6.2 7.9 -6.5
Leg fat mass (left) 1.3 5.1 7.9 -1.4 -2.8 -2.7 2.3 2.1 -1.9
Arm predicted mass (left) 0.2 1.0 3.7 -1.0 -1.9 -0.3 0.4 -1.1 -0.1