Hub : Genes

NSF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.097	0.036	0.00015	0.009	0.04	0.037	0.038	0.018	2.4e-02	1.1e-05	2.2e-05	1.7e-05	0.00270
2	GTEx	Cells EBV-transformed lymphocytes	0.200	0.082	0.00380	0.075	NA	0.092	NA	0.102	2.0e-03	NA	6.5e-04	NA	0.00034
3	GTEx	Cells Transformed fibroblasts	0.059	0.028	0.00490	0.025	NA	0.022	NA	0.024	4.9e-03	NA	7.8e-03	NA	0.00570
4	GTEx	Esophagus Muscularis	0.166	0.069	0.00044	0.005	NA	0.006	NA	-0.003	1.5e-01	NA	1.4e-01	NA	0.50000
5	GTEx	Prostate	0.195	0.076	0.00200	-0.011	NA	-0.012	NA	-0.010	7.3e-01	NA	9.7e-01	NA	0.70000
6	GTEx	Testis	0.100	0.047	0.00200	0.095	NA	0.043	NA	0.065	5.3e-05	NA	5.3e-03	NA	0.00079

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	1.1	0.0	0.8	1.0	-0.7	0.0	1.1
Bipolar Disorder or Schizophrenia	0.7	1.6	2.7	-1.2	-0.4	-1.5	-1.0	1.4	-1.6
Depressed Affect (Nagel 2018)	23.2	48.7	82.1	3.5	6.6	8.0	-5.5	-7.7	9.1
Depression (Nagel 2018)	7.8	11.8	19.4	0.9	2.9	3.7	-3.7	-4.4	3.9
Intelligence (Savage-Jansen 2018)	6.4	19.7	36.7	-1.0	-6.1	-4.5	5.3	3.7	-4.4
Neuroticism (Nagel 2018)	28.8	67.7	103.7	3.5	8.4	9.0	-7.2	-9.2	10.2
Schizophrenia (2018)	2.0	4.2	9.0	-1.7	-1.3	-2.8	-0.7	1.8	-3.0
Schizophrenia vs Biploar Disorder	3.3	4.3	9.2	-2.3	-1.3	-2.8	0.2	1.4	-3.0
Worry (Nagel 2018)	16.9	35.6	48.6	2.8	6.2	6.5	-5.4	-7.0	6.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.2	-0.4	-0.8	0.6	-0.4	-0.2
Alzheimer’s Disease (in father)	0.4	0.5	1.4	-0.2	-0.5	-1.2	-0.3	0.4	-1.0
Alzheimer’s Disease (including proxy)	1.1	1.6	4.2	-0.7	-1.1	-2.0	0.4	0.7	-1.8
Crohns Disease (2017)	2.4	5.3	9.6	-0.7	-3.1	-2.7	1.8	2.3	-2.4
Irritable Bowel Disease (IBD)	1.3	3.1	5.2	-1.2	-2.0	-2.1	1.1	1.4	-2.3
Ulcerative Colitis (UC)	0.3	0.6	1.9	-1.0	-0.1	-0.8	0.1	0.2	-1.4
Major Depression (MDD)	1.5	1.8	7.9	2.8	-0.9	0.2	1.0	-0.7	0.8
Reaction Time	10.1	19.2	52.7	-1.8	6.9	1.4	-7.3	-3.0	0.9
Verbal and Numeric Reasoning (VNR)	4.2	10.0	13.7	-1.8	-3.6	-3.7	2.9	3.1	-3.4
Breast Cancer	8.8	21.2	33.1	2.1	4.0	4.9	-4.7	-5.8	5.2
Ovarian Cancer	18.1	23.9	44.6	-4.6	-3.7	-6.1	2.1	4.7	-6.7
Prostate Cancer	1.2	1.7	3.2	0.0	-1.5	-0.7	1.2	1.8	-1.7
Age at First Birth	1.2	1.7	4.0	-0.5	-1.1	-1.2	-0.1	1.7	-2.0
Bipolar Disorder (2011)	0.6	0.6	1.5	-0.2	0.0	0.9	-0.8	-0.7	1.2
Body Mass Index (BMI) (2010)	1.3	1.7	6.2	0.3	-0.2	1.0	-1.6	-2.5	0.7
Coronary Artery Disease (CAD)	1.9	2.2	6.7	2.6	0.1	1.7	1.1	-0.2	1.6
Crohns Disease (2012)	4.1	6.5	11.9	-1.8	-2.6	-3.4	1.3	2.0	-3.5
Mean Putamen Volume	9.2	10.5	19.7	1.0	3.0	4.4	-2.7	-3.3	3.8
Fasting Glucose	1.4	1.6	4.2	0.2	-1.1	-2.0	0.6	1.2	-1.6
HbA1C	0.2	0.3	0.6	0.6	-0.5	0.6	-0.2	-0.4	0.7
HDL Cholesterol	1.8	3.0	11.0	3.3	-0.8	-0.1	2.4	0.9	0.4
LDL Cholesterol	2.9	4.6	7.7	2.8	2.3	1.8	-0.8	-1.8	2.7
Lupus	4.8	7.3	10.4	0.7	-3.0	-3.2	2.6	3.0	-2.9
Neuroticism (2016)	10.7	15.4	20.3	2.1	4.4	4.0	-3.6	-4.5	4.5
Primary Biliary Cirrhosis	9.5	13.6	18.0	-3.5	-3.6	-4.2	2.9	3.5	-4.2
Rheumatoid Arthritis	1.4	2.0	3.9	0.9	1.9	1.1	-2.0	-1.0	1.1
Schizophrenia (2014)	2.9	6.4	12.0	-2.9	-1.1	-3.2	-1.0	2.3	-3.5
Triglycerides	1.1	1.7	2.8	-0.8	-1.7	-1.4	1.4	1.2	-1.3
Type 2 Diabetes (T2D) (2012)	1.9	2.2	3.8	-0.9	-1.6	-1.1	1.9	1.9	-1.1
Ulcerative Colitis	0.4	0.6	1.9	-1.4	-0.2	-0.7	-0.1	0.1	-1.1
Blood Eosinophil Count	9.8	75.2	141.6	-2.0	-7.2	-10.5	7.2	9.5	-11.9
Blood Platelet Count	0.9	10.5	24.6	5.0	-0.9	2.9	3.0	-0.9	4.4
Blood Red Count	24.6	237.3	449.4	13.8	11.7	19.2	-6.9	-15.2	21.2
Blood White Count	1.1	8.1	15.8	2.5	1.7	3.2	-1.1	-3.4	4.0
Heel T-Score	6.7	53.1	86.9	-2.5	-7.7	-8.4	5.7	8.0	-9.3
BMI	0.2	0.9	2.8	0.5	-0.7	0.3	0.1	-1.7	1.4
Height	4.1	80.0	148.8	-6.1	-12.2	-9.1	7.3	7.6	-10.0
Waist Hip Ratio (WHR)	7.9	35.4	80.1	5.4	3.2	8.1	-1.8	-5.0	8.9
Systolic Blood Pressure	8.1	40.3	80.8	0.7	-6.6	-5.0	8.5	9.0	-4.5
Smoking Status	4.8	11.4	19.2	-0.5	-4.4	-3.9	3.4	2.7	-3.8
Allergy or Eczema	0.6	1.5	2.8	-1.5	-1.1	-1.7	0.1	0.4	-1.5
Cardiovascular Disease	2.6	8.5	23.1	1.3	-3.0	-1.3	4.8	3.8	-0.8
Hypothyroidism (self reported)	0.8	1.8	4.8	-0.8	0.3	1.3	-0.2	-2.2	1.9
Respiratory disease	0.4	0.8	2.3	0.6	-0.7	-1.1	1.5	0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	-0.6	0.2	-0.8	-0.0	0.8
Lung FEV1/FVC ratio	2.9	14.6	25.3	-3.6	-1.7	-5.0	1.5	4.9	-4.4
Lung FVC	26.1	132.9	213.2	-3.2	-13.2	-12.5	10.0	12.0	-14.6
Neuroticism	26.8	64.6	102.0	3.6	7.9	9.3	-6.5	-9.0	10.1
Chronotype (morning person)	1.5	3.6	13.9	3.7	-0.5	1.3	1.1	-1.4	1.5
Hair Pigment	0.4	11.8	25.0	-4.4	-0.6	-4.3	-0.0	2.7	-5.0
Tanning	0.5	6.2	12.6	-1.7	-1.7	-2.7	1.7	3.0	-3.5
Hand grip strength (left)	10.7	28.2	46.8	-2.5	-5.8	-5.9	4.6	5.3	-6.8
Number of treatments/medications taken	0.4	0.6	1.8	0.9	-0.2	0.3	1.0	-0.3	1.4
Average weekly spirits intake	0.6	0.8	2.2	0.7	-1.4	-0.1	1.5	0.3	0.3
Sensitivity / hurt feelings	27.8	47.6	73.9	2.9	7.0	7.7	-6.1	-7.6	8.6
Frequency of depressed mood in last 2 weeks	8.8	12.3	17.1	1.1	3.4	4.0	-3.4	-4.1	4.1
Hearing difficulty/problems: Yes	4.4	6.7	18.3	-0.1	4.3	1.8	-3.3	-1.8	2.3
Relative age of first facial hair	32.9	67.7	110.2	4.4	7.4	10.5	-6.3	-8.6	10.4
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.4	-0.5	1.3	1.0	-1.9	-2.5	1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	-0.4	0.6	-0.0	-0.8	-0.2	0.1
Ever had hysterectomy (womb removed)	0.8	0.9	1.6	1.0	0.7	1.2	-0.8	-0.5	1.1
Systolic blood pressure, automated reading	10.3	30.0	55.0	-1.3	-5.4	-5.4	6.6	7.4	-4.7
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	6.2	-2.5	0.2	-0.6	-0.4	1.9	-0.5
Angina	0.3	0.4	2.0	-0.3	0.0	0.2	0.6	1.4	0.1
Medication for hormone replacement therapy	1.4	1.5	4.9	-0.6	-1.3	-1.4	-0.3	0.3	-2.2
Vitamin and mineral supplements	6.5	8.8	16.0	-2.6	-1.3	-3.6	1.3	4.0	-3.7
Supplements: Zinc	3.6	4.0	5.8	2.3	1.3	2.2	-1.2	-2.2	2.4
Medication: Co-codamol	0.2	0.2	0.4	0.3	-0.4	-0.2	0.5	-0.6	0.6
Medication: Metformin	0.2	0.2	0.6	-0.2	-0.6	0.3	0.1	0.8	0.6
Diabetes (father)	1.3	1.6	5.2	0.2	1.2	1.3	-0.1	-1.1	2.3
Diabetes (mother)	0.3	0.4	1.2	-0.1	-1.1	-0.1	0.0	1.0	-0.2
Severe depression (siblings)	3.1	3.5	6.1	0.9	1.6	2.2	-1.1	-2.4	2.5
Pack years adult smoking proportion	0.6	0.9	2.2	1.5	-1.1	0.0	1.1	0.2	0.8
Impedance of leg (right)	2.6	12.6	24.5	-1.9	-2.5	-4.0	2.9	5.0	-4.0
Leg fat-free mass (left)	0.6	3.0	12.5	-0.8	-3.5	-0.4	2.1	-0.1	-0.3
Trunk fat percentage	8.5	34.0	48.5	-2.6	-7.0	-6.2	6.2	6.5	-5.6
Hand grip strength (right)	8.5	23.0	35.8	-2.6	-5.6	-5.0	4.2	4.7	-6.0
Townsend deprivation index at recruitment	0.4	0.6	2.3	1.5	0.2	-0.1	0.3	-1.0	0.4
Current tobacco smoking	1.9	3.1	5.5	0.6	-2.0	-2.3	2.3	1.2	-1.6
Average weekly fortified wine intake	3.5	4.1	9.6	-3.1	0.5	-2.8	-0.2	1.3	-2.4
Maternal smoking around birth	0.5	0.7	1.8	1.2	-1.3	-0.1	0.9	-0.1	-0.1
Fed-up feelings	11.1	20.2	38.6	4.3	3.5	5.2	-1.9	-4.6	6.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	11.0	1.3	1.4	1.9	-1.6	-3.3	2.0
Relative age voice broke	21.1	32.2	53.7	3.7	4.6	7.3	-4.0	-6.0	7.3
Taking other prescription medications	0.0	0.0	0.1	-0.2	-0.1	0.0	0.1	-0.2	0.4
Age when periods started (menarche)	2.6	6.2	12.3	0.8	2.4	3.0	-1.6	-2.6	3.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	1.1	1.5	0.8	-0.9	-0.9	1.1
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	9.6	-1.7	-2.3	-2.6	2.2	3.1	-3.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.2	0.2	-0.6	1.1	0.6	-0.2
Qualifications: CSEs or equivalent	7.0	9.2	17.0	3.4	1.3	4.1	-1.2	-2.7	4.0
Serious illness, injury or assault to yourself	0.9	1.1	2.8	-0.3	1.7	1.1	-1.0	-0.2	1.1
High blood pressure	5.1	14.2	25.4	-0.9	-3.7	-3.8	4.2	5.0	-3.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.1	-0.7	-0.8	0.0	0.0	-0.8
Multivitamins +/- minerals	2.8	3.6	6.1	2.2	0.3	2.3	0.0	-2.5	2.3
Stomach or abdominal pain in last month	1.3	1.6	2.7	1.2	1.2	1.1	-1.3	-1.0	1.6
Supplements: Glucosamine	0.2	0.2	0.6	-0.8	-0.7	0.1	0.3	0.1	0.1
Diverticular disease/diverticulitis (self-reported)	5.5	6.5	11.2	-1.3	-2.5	-3.0	1.4	2.9	-3.3
Medication: Atenolol	3.0	3.7	7.2	-1.7	-2.1	-1.9	1.3	2.7	-1.6
Medication: Levothyroxine sodium	1.5	2.5	5.2	-0.9	1.2	1.9	-1.0	-1.8	2.3
Sitting height	9.8	69.4	100.0	-7.6	-9.2	-8.8	6.0	7.8	-10.0
Chronic bronchitis/emphysema (father)	0.6	0.7	3.7	-1.9	0.3	-0.3	-0.5	0.5	-0.3
High blood pressure (mother)	1.6	2.2	4.5	0.4	-1.6	-2.1	1.1	1.2	-1.8
Body mass index (BMI)	0.0	0.2	0.5	-0.2	-0.6	-0.4	0.7	-0.0	0.4
Impedance of leg (left)	2.8	13.7	26.1	-1.8	-2.4	-4.4	2.7	5.1	-4.5
Leg predicted mass (left)	0.6	3.2	13.1	-0.8	-3.6	-0.5	2.2	0.0	-0.3
Trunk fat mass	6.0	25.6	42.8	-2.4	-6.5	-5.2	5.5	5.1	-4.6
Waist circumference	0.3	1.2	2.6	0.4	-1.6	0.7	1.2	-0.4	1.6
Number of incorrect matches in round	5.0	8.2	12.6	0.4	3.6	2.8	-3.4	-3.5	2.3
Past tobacco smoking	3.7	6.7	11.0	1.5	3.1	2.8	-2.2	-2.2	3.3
Alcohol usually taken with meals	1.2	2.0	6.1	-2.5	-1.0	-1.3	-0.3	-0.1	-1.7
Nervous feelings	14.9	27.8	36.7	3.0	5.4	5.5	-5.1	-6.1	5.9
Frequency of tenseness / restlessness in last 2 weeks	19.5	30.4	45.2	3.0	5.8	5.5	-4.7	-6.7	6.5
Hearing difficulty/problems with background noise	8.1	12.9	18.2	1.7	4.3	3.3	-3.8	-4.1	3.9
Hair/balding pattern: Pattern 2	17.1	21.7	37.6	3.3	3.5	5.9	-3.2	-4.8	6.1
Had menopause	0.5	0.6	1.3	-1.1	0.6	-0.7	-1.1	-0.3	-0.6
Had other major operations	0.1	0.1	0.1	-0.1	0.4	0.4	-0.3	0.2	0.3
Forced vital capacity (FVC)	27.2	104.8	166.4	-3.1	-12.9	-10.1	10.4	10.5	-11.5
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	8.4	-1.0	-1.9	-2.4	2.2	2.9	-2.6
Ever unenthusiastic/disinterested for a whole week	10.2	12.5	20.5	2.8	2.8	4.5	-2.3	-3.8	4.4
Qualifications: None of the above	3.2	6.8	19.8	0.7	4.4	1.7	-2.8	-2.4	2.1
Financial difficulties in last 2 years	3.7	5.0	9.0	2.4	1.7	2.3	-0.5	-2.6	3.0
Mouth/teeth dental problems	5.1	7.9	15.9	1.0	-4.0	-2.8	3.3	1.2	-3.3
Heart attack	0.6	0.8	1.6	-1.3	1.1	0.7	-1.2	-0.2	0.6
Allergy	0.0	0.1	0.3	-0.2	0.3	0.3	0.3	0.6	0.1
Pain all over the body in last month	0.3	0.4	0.8	0.6	0.9	-0.4	0.3	-0.8	0.5
Diabetes (self-reported)	0.4	0.6	1.7	-1.0	-0.5	-0.5	-0.6	1.3	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.5	-0.2	0.2	0.3	-1.2	-0.1	0.3
Medication: Ramipril	0.5	0.7	1.3	-1.0	-1.1	-0.5	0.8	0.8	-0.6
Medication: Simvastatin	0.4	0.6	1.8	-1.1	-0.3	-0.1	0.7	1.4	-0.1
Fluid intelligence score	4.6	9.7	14.8	-1.7	-3.0	-3.9	3.3	3.1	-3.2
Illnesses of siblings	1.7	2.4	8.8	3.0	-0.8	0.4	1.1	-1.7	0.9
Neuroticism score	22.5	47.0	75.1	3.6	6.7	7.8	-5.5	-7.6	8.7
Weight	1.4	7.1	17.4	-1.6	-4.2	-2.4	3.2	1.8	-1.8
Impedance of arm (right)	8.7	40.5	60.3	-1.1	-7.3	-5.8	7.5	7.8	-6.2
Arm fat percentage (right)	2.7	10.7	21.7	0.1	-4.4	-2.8	4.7	3.3	-2.1
Trunk fat-free mass	0.3	1.4	4.7	-0.5	-1.4	0.9	-0.0	-2.2	0.9
Hip circumference	1.8	7.7	11.6	-2.4	-3.4	-3.3	2.6	2.0	-2.6
Time employed in main current job	8.0	9.2	19.4	-1.2	-2.5	-3.7	2.3	3.1	-4.4
Alcohol intake versus 10 years previously	0.3	0.4	1.2	0.4	-0.3	-0.4	1.1	0.8	-0.0
Father’s age at death	0.6	0.8	1.7	-0.7	-0.7	-1.3	0.3	-0.0	-1.3
Worrier / anxious feelings	12.1	22.9	31.3	1.8	5.1	4.9	-4.9	-5.6	5.3
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	12.2	1.2	1.9	1.8	-1.7	-3.5	3.0
Falls in the last year	4.2	5.7	7.9	-0.1	2.4	2.5	-2.6	-2.7	2.8
Hair/balding pattern: Pattern 3	32.6	48.5	95.3	-3.7	-6.5	-8.5	4.6	6.8	-9.8
Number of live births	8.1	11.4	19.4	2.8	2.9	4.1	-1.7	-3.6	4.4
Forced expiratory volume in 1-second (FEV1)	27.2	91.7	134.6	-3.4	-11.6	-9.8	9.4	10.1	-10.9
Pulse rate	1.3	2.2	5.7	-2.4	0.9	-1.0	-1.9	-0.3	-1.3
Happiness	1.0	1.3	3.3	1.3	0.9	1.1	0.4	-0.7	1.8
Noisy workplace	3.6	4.4	8.1	1.3	2.2	2.4	-1.5	-2.0	2.8
Qualifications: A levels/AS levels or equivalent	6.4	14.3	21.7	-3.7	-4.7	-3.1	3.6	3.9	-3.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	-0.0	-0.5	0.5	0.6	-0.2
Mouth/teeth dental problems: Dentures	1.3	2.1	6.8	-2.6	1.1	-1.6	-1.0	0.5	-0.9
Asthma	0.4	0.8	1.7	1.3	-0.4	-1.1	1.0	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	7.5	9.5	15.7	3.4	2.5	2.7	-1.5	-4.0	3.7
Medication: Cholesterol lowering	0.5	0.7	1.7	0.5	-1.0	-0.1	1.3	1.2	0.2
Depression (self-reported)	2.4	2.9	4.4	1.6	2.0	1.2	-1.4	-2.1	1.6
Medication: Lansoprazole	1.7	2.0	3.8	-0.7	-1.0	-1.7	0.3	1.9	-1.9
Prospective memory result	2.7	3.3	5.3	1.2	1.1	2.3	-2.2	-1.8	1.9
Lung cancer (father)	0.4	0.4	1.7	-1.3	-0.2	0.2	-0.6	0.6	-0.2
Illnesses of mother	0.6	0.8	1.8	-0.9	-0.4	-0.8	1.3	0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	25.2	80.5	114.5	-3.3	-10.7	-9.4	9.2	9.1	-10.1
Pulse wave Arterial Stiffness index	1.3	1.5	4.1	-2.0	-0.5	-1.6	0.4	0.5	-1.1
Impedance of arm (left)	9.3	43.0	68.1	-2.0	-7.3	-6.0	7.3	8.3	-6.6
Arm fat mass (right)	1.8	7.4	16.0	-0.6	-4.0	-2.4	3.6	2.4	-1.8
Trunk predicted mass	0.2	1.4	4.7	-0.5	-1.4	0.9	-0.1	-2.2	0.9
Standing height	3.5	34.3	72.2	-3.9	-8.5	-5.0	6.0	4.9	-5.7
Length of working week for main job	0.5	0.5	1.4	0.1	-0.8	-1.2	0.2	0.4	-1.0
Exposure to tobacco smoke at home	1.4	1.5	4.6	-0.3	1.9	0.5	-2.1	-0.7	0.3
Breastfed as a baby	0.2	0.3	0.7	-0.5	0.0	-0.8	0.1	0.1	-0.8
Tense / ‘highly strung’	4.8	7.9	12.7	1.6	2.7	3.1	-2.1	-3.6	3.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	10.5	3.2	-0.6	0.7	1.1	-0.2	1.1
Hair/balding pattern: Pattern 4	68.1	164.9	259.2	-7.9	-11.3	-15.3	10.2	14.2	-16.1
Birth weight of first child	2.1	3.7	8.2	-1.1	-2.9	-2.2	1.7	0.9	-2.1
Peak expiratory flow (PEF)	13.8	32.0	49.3	-3.0	-5.8	-6.5	4.6	6.0	-7.0
Pulse wave reflection index	0.2	0.2	0.9	-0.1	-0.0	0.2	0.3	-0.6	0.9
Ever highly irritable/argumentative for 2 days	2.7	3.2	6.5	1.2	2.0	1.6	-1.2	-1.8	2.5
Loud music exposure frequency	1.6	1.7	4.3	1.8	-2.1	-0.5	1.4	-0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	3.2	5.0	9.0	-1.9	-3.0	-1.5	2.4	2.0	-2.3
Mouth/teeth dental problems: Bleeding gums	3.6	4.7	7.7	0.3	2.8	2.6	-2.3	-1.4	2.5
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.4	-0.2	0.8	0.4	-1.0	0.6
Medication: Paracetamol	13.6	22.5	45.7	4.7	3.9	5.0	-1.9	-4.8	6.8
Headache pain in last month	20.5	35.2	63.9	3.7	4.7	7.2	-4.1	-6.5	8.0
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	5.6	-0.5	2.1	1.4	-2.3	-2.4	0.9
Glaucoma (self-reported)	3.5	4.1	7.5	0.4	2.0	2.7	-2.2	-1.6	2.4
Gout (self-reported)	1.3	1.8	4.9	-0.2	0.1	-2.2	0.0	1.1	-2.1
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	6.2	-0.6	1.3	1.7	-0.9	-2.5	2.3
Medication: Amlodipine	3.5	4.9	8.3	-0.5	-2.1	-2.9	2.5	2.0	-2.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.5	-0.6	-0.3	-1.6	0.6	1.3	-1.2
Birth weight	0.5	1.1	3.5	0.5	-1.9	-0.4	1.6	0.3	-0.1
Chronic bronchitis/emphysema (mother)	3.6	4.2	8.4	1.3	2.9	2.1	-1.6	-1.9	2.1
High blood pressure (siblings)	3.7	5.3	11.1	-2.1	-1.4	-2.3	1.0	3.3	-2.8
Forced vital capacity (FVC), Best measure	26.7	97.7	151.3	-3.2	-12.3	-10.1	10.2	9.8	-11.1
Body fat percentage	5.2	20.4	27.9	-2.1	-5.3	-4.9	4.9	5.1	-4.1
Leg fat percentage (right)	1.1	4.1	7.8	-1.0	-1.9	-2.8	1.9	2.3	-1.8
Arm fat-free mass (right)	0.2	0.9	2.0	-1.4	-1.3	-0.1	-0.4	-1.4	0.1
Exposure to tobacco smoke outside home	4.0	5.4	10.5	-0.6	2.3	2.7	-2.3	-1.8	3.2
Comparative body size at age 10	2.3	6.3	19.1	4.4	-1.5	1.9	1.0	-2.5	2.4
Number of full brothers	8.0	10.1	17.6	0.3	4.2	4.0	-2.9	-2.4	3.6
Worry too long after embarrassment	6.4	10.7	17.2	0.6	3.7	3.4	-3.2	-3.4	4.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	1.1	-0.4	0.4	-0.2	-1.0	0.6
Wheeze or whistling in the chest in last year	2.2	3.8	6.4	1.3	2.5	1.8	-1.9	-1.9	2.3
Number of children fathered	1.1	1.3	2.5	-1.5	1.6	0.5	-1.4	-0.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.4	0.4	1.9	0.4	-1.7	-1.8	0.7
Age at first live birth	6.0	10.7	17.9	-1.2	-4.2	-3.4	3.1	3.5	-3.4
Pulse wave peak to peak time	0.6	0.7	2.6	1.6	-0.3	1.2	0.2	0.1	0.6
Health satisfaction	0.4	0.6	2.1	1.4	0.1	0.3	0.7	-0.3	0.9
Shortness of breath walking on level ground	0.6	0.7	1.8	0.6	0.4	0.7	0.2	-1.2	1.3
Qualifications: College or University degree	10.2	32.3	44.5	-4.5	-6.7	-5.9	4.3	5.9	-6.4
Eye problems/disorders: None of the above	1.5	1.7	4.3	0.3	-1.3	-1.5	2.1	0.6	-1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.1	0.2	-0.8	0.4	0.6	-0.6
Emphysema/chronic bronchitis	5.7	6.4	11.4	0.7	2.8	2.4	-2.7	-2.3	3.4
Medication for pain relief, constipation, heartburn	7.7	13.1	25.8	-3.0	-3.4	-3.8	1.9	3.7	-5.1
Neck or shoulder pain in last month	1.6	2.2	4.7	-1.5	-0.1	-2.2	0.0	1.5	-2.0
Medication: Blood pressure	2.0	3.5	5.7	0.2	-2.2	-1.9	2.0	2.4	-1.5
Angina (self-reported)	0.3	0.4	1.5	-0.5	-0.2	0.3	0.5	1.2	0.2
Migraine (self-reported)	1.3	1.6	3.3	-0.0	1.1	1.8	-0.8	-1.2	1.7
Medication: Ibuprofen	5.6	6.7	11.1	2.5	2.3	2.2	-1.3	-3.3	3.3
Medication: Allopurinol	1.4	1.8	3.5	1.2	-0.4	-1.9	1.1	1.3	-1.7
Medication: Omeprazole	1.4	1.6	5.4	-2.3	-0.6	-1.0	0.6	1.0	-1.2
Medication: Seretide 50 evohaler	1.4	1.6	3.3	1.8	-1.6	-1.0	1.1	0.7	-1.1
Mean time to correctly identify matches	9.8	18.7	53.4	-3.1	6.6	0.4	-7.3	-2.5	-0.1
Heart disease (mother)	3.8	4.7	7.2	1.3	2.1	2.2	-1.8	-2.7	2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.3	7.5	12.8	-0.4	3.6	2.5	-3.1	-2.8	2.8
Whole body fat mass	3.6	14.9	26.3	-1.9	-5.1	-4.0	4.3	3.8	-3.3
Leg fat mass (right)	1.5	5.6	9.0	-1.4	-3.0	-2.7	2.6	2.3	-1.9
Arm predicted mass (right)	0.2	1.0	3.1	-1.1	-1.1	0.4	-0.6	-1.8	0.5
Pulse rate, automated reading	1.4	4.7	15.8	-4.0	-0.3	-2.3	-1.8	0.9	-1.8
Alcohol intake frequency.	9.6	22.4	39.8	2.7	3.5	6.2	-3.5	-4.9	6.3
Comparative height size at age 10	4.2	22.9	32.6	-2.5	-5.7	-5.0	4.7	4.7	-5.4
Number of full sisters	0.5	0.6	1.4	0.6	0.7	1.2	0.2	-0.5	1.2
Suffer from ‘nerves’	7.3	11.5	17.7	0.2	3.9	3.5	-3.5	-4.2	3.4
Overall health rating	0.2	0.4	1.3	0.4	0.6	0.2	-0.5	0.2	1.1
Chest pain or discomfort	1.5	2.1	4.0	-1.7	-0.9	-1.8	0.9	2.0	-1.1
Had major operations	1.1	1.3	2.7	-1.0	1.6	0.3	-1.6	-0.7	1.1
Age at last live birth	6.1	8.8	19.7	-0.4	-4.4	-2.7	3.5	2.8	-2.3
Family relationship satisfaction	0.1	0.2	0.6	-0.1	0.4	0.4	-0.1	-0.2	0.8
Leg pain on walking	5.3	6.7	10.7	1.3	3.1	2.9	-2.0	-2.4	3.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.7	1.1	0.4	1.2	0.9	0.0	1.6
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.5	-0.1	1.3	1.5	-1.7	-0.8	1.9
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	5.2	-0.1	-1.7	-2.0	1.2	0.9	-2.3
Medication: Aspirin	0.3	0.4	1.1	0.2	0.8	0.6	-0.4	-0.4	1.1
Supplements: Vitamin C	9.0	10.6	18.7	2.4	2.1	3.9	-1.9	-4.3	4.0
Knee pain experienced in last month	0.2	0.3	0.6	0.8	0.6	-0.1	-0.4	-0.5	0.4
Hypertension (Self-reported)	4.7	13.0	23.2	-0.8	-3.5	-3.8	3.9	4.8	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	5.8	-1.1	-1.2	-2.4	1.7	2.2	-2.2
Illnesses of father: Heart disease	4.1	5.7	12.7	0.2	2.7	3.2	-1.6	-0.9	3.6
Illnesses of siblings: Diabetes	0.3	0.3	1.2	-0.5	0.5	0.5	-0.2	-0.2	1.1
Smoking status: Previous	3.7	5.5	9.3	-1.0	-2.6	-2.6	2.0	2.3	-3.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	-0.3	-1.7	-0.7	1.0	0.3	-0.8
Whole body fat-free mass	0.2	1.4	5.3	-0.9	-2.3	0.2	0.7	-1.3	0.4
Leg fat-free mass (right)	0.5	2.6	11.6	-0.7	-3.4	-0.3	1.9	-0.2	-0.2
Arm fat percentage (left)	2.9	11.7	20.5	-0.4	-4.5	-3.1	4.4	3.7	-2.5
Average weekly red wine intake	1.7	2.5	5.7	-2.2	0.1	-1.7	-1.2	0.1	-2.4
Handedness (chirality/laterality): Left-handed	17.8	21.3	30.4	-0.5	-5.1	-4.7	5.2	4.7	-5.5
Mood swings	20.1	36.3	58.6	2.7	6.1	6.9	-4.8	-6.6	7.7
Loneliness, isolation	7.8	10.8	18.5	1.2	3.1	4.2	-2.5	-3.4	4.3
Long-standing illness, disability or infirmity	0.4	0.7	1.5	0.4	1.2	0.4	-0.9	-0.5	1.0
Ever had bowel cancer screening	5.0	5.8	10.6	-1.4	-1.7	-3.3	1.5	2.6	-3.2
Diabetes diagnosed by doctor	0.6	1.0	2.9	-1.4	-0.7	-0.8	-0.1	1.7	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.7	-0.1	-0.2	-0.1	0.8	0.3	0.2
Friendships satisfaction	0.8	1.0	2.4	1.0	0.1	1.2	0.9	-0.6	1.6
Qualifications: nursing, teaching	3.2	5.0	8.2	-1.6	-2.4	-2.1	1.4	2.7	-2.9
Commuting to job workplace: Walk	0.1	0.1	0.3	0.4	0.3	0.2	0.2	0.6	-0.1
Eye problems/disorders: Cataract	1.5	1.8	4.4	-0.1	2.1	1.1	-1.4	-1.1	1.3
Mouth/teeth dental problems: Mouth ulcers	12.3	19.5	39.7	3.2	3.7	5.9	-2.8	-3.4	6.3
Medication for cholesterol	4.7	7.1	12.0	1.2	2.6	2.9	-2.0	-3.5	3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.5	-0.3	-0.7	-0.2	-0.4	-0.9
Back pain experienced in last month	0.7	1.0	2.1	-1.5	1.0	-1.2	-0.9	0.5	-0.8
Mineral and other dietary supplements	0.9	1.2	2.3	-0.1	-0.7	-1.4	0.9	1.5	-1.2
Breast cancer (self-reported)	3.7	4.5	7.7	-2.2	-0.7	-2.8	0.9	2.4	-2.7
Asthma (self-reported)	0.3	0.6	1.6	1.3	-0.3	-0.9	0.8	0.5	-0.5
Osteoporosis (self-reported)	3.2	4.0	6.3	1.4	2.5	1.9	-1.6	-2.1	2.2
Osteoarthritis (self-reported)	0.4	0.5	1.4	-1.2	-0.0	-0.9	0.2	0.4	-0.7
Medication: Aspirin	0.3	0.4	0.9	-0.3	0.9	0.3	-0.5	-0.4	0.9
Medication: Gliclazide	0.4	0.4	1.0	0.5	-0.8	0.7	0.4	-0.3	1.0
Illnesses of father: None of the above (group 1)	3.4	4.2	7.2	-0.0	-2.4	-2.4	1.8	1.8	-2.7
Smoking status: Current	1.8	2.9	4.9	0.4	-1.9	-2.2	2.2	1.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	22.6	47.7	68.9	-3.5	-6.7	-8.0	6.0	7.7	-8.3
Whole body water mass	0.2	1.3	4.6	-0.8	-2.1	0.4	0.6	-1.4	0.5
Leg predicted mass (right)	0.5	2.4	10.8	-0.7	-3.3	-0.3	1.8	-0.3	-0.2
Arm fat mass (left)	1.8	7.4	16.3	-0.9	-4.0	-2.3	3.5	2.6	-1.8
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.1	-0.3	0.1	0.6	0.4	0.6
Average weekly champagne plus white wine intake	11.5	15.8	20.0	-4.4	-3.7	-4.2	2.6	4.0	-4.5
Miserableness	11.7	20.2	33.5	2.5	4.4	5.0	-3.2	-5.2	5.8
Guilty feelings	7.6	11.4	19.8	2.2	3.2	3.9	-2.5	-3.6	4.4
Wears glasses or contact lenses	0.5	0.6	1.8	-0.8	-0.1	0.4	-1.3	-1.0	0.3
Ever taken oral contraceptive pill	2.3	2.5	6.4	0.4	0.7	1.6	-1.2	-2.5	2.0
Hearing aid user	0.8	0.9	3.4	0.7	0.4	1.1	-0.1	0.1	1.9
Mother’s age at death	0.6	0.8	3.5	-1.9	0.2	-0.0	-0.8	-0.2	-0.5
Financial situation satisfaction	0.8	1.0	1.8	1.4	-0.7	1.0	1.3	-0.4	0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-0.8	1.1	0.1	-1.1	-0.2	0.7
Commuting to job workplace: Public transport	1.9	2.2	5.5	-0.4	-1.0	-2.3	0.6	1.0	-2.3
Eye problems/disorders: Glaucoma	5.0	5.9	11.4	0.3	2.4	3.4	-2.5	-1.9	2.8
Medication: Blood pressure	8.3	15.8	28.5	-2.1	-4.0	-3.9	3.5	5.3	-4.2
Pain type(s) experienced in last month: Hip pain	3.0	3.8	5.8	0.7	2.4	2.1	-2.1	-2.0	1.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.7	0.8	0.4	0.8	-0.2	-1.3	0.8
High cholesterol (Self-reported)	2.3	4.0	10.5	-1.2	-1.5	-1.9	2.0	3.2	-1.6
Medication: Bendroflumethiazide	3.5	5.4	10.7	-0.2	-2.1	-2.2	3.3	2.8	-2.1
Medication: Paracetamol	14.1	21.8	42.2	3.8	4.4	4.9	-2.6	-4.9	6.5
Medication: Lisinopril	2.9	3.7	7.3	0.7	-2.7	-0.9	2.1	2.5	-1.6
Medication: Atorvastatin	0.6	0.8	3.6	0.0	0.0	-0.8	0.8	1.9	0.0
Illnesses of father: High blood pressure	1.3	1.6	2.7	0.3	-1.3	-1.3	1.6	1.1	-1.4
Alcohol drinker status: Never	2.2	2.6	4.3	0.6	1.4	1.8	-1.6	-1.8	2.1
Ever smoked	2.3	4.1	7.6	-0.4	-2.4	-2.3	2.0	1.3	-2.8
Basal metabolic rate	0.3	1.9	8.2	-0.8	-2.9	-0.2	1.4	-0.6	-0.0
Leg fat percentage (left)	1.2	4.4	9.0	-0.9	-1.8	-3.0	1.7	2.4	-2.1
Arm fat-free mass (left)	0.2	0.8	2.3	-0.7	-1.5	0.1	0.1	-1.3	0.3
Number of operations (self-reported)	1.6	2.4	3.9	0.0	1.3	1.4	-1.8	-1.8	2.0
Average weekly beer plus cider intake	2.1	3.0	5.5	0.2	-0.8	-2.3	1.2	2.3	-2.3
Irritability	10.3	17.5	33.6	2.8	3.6	5.1	-2.4	-4.4	5.8
Risk taking	1.5	2.2	4.7	1.3	1.5	1.5	-0.7	-2.2	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.9	0.5	-1.7	-0.5	1.3	-0.9	-0.5
Fractured/broken bones in last 5 years	9.1	11.7	15.8	1.7	3.8	4.0	-3.0	-3.6	3.8
Age started oral contraceptive pill	1.8	2.2	4.2	-1.3	-0.1	-2.0	0.9	2.1	-1.7
Diastolic blood pressure, automated reading	2.9	9.1	15.3	-2.6	-2.4	-3.4	3.0	3.9	-2.6
Ever depressed for a whole week	4.5	5.6	13.1	1.4	2.1	3.1	-1.2	-1.6	3.6
Unable to work because of sickness or disability	0.6	0.8	2.3	1.4	-0.1	0.0	-0.2	-1.5	0.6
Commuting to job workplace: Cycle	0.9	1.1	3.5	-1.9	-1.1	0.4	0.9	1.0	-0.2
Myopia	5.5	7.9	16.5	-0.8	-2.4	-4.1	1.4	2.9	-3.8
Vascular/heart problems diagnosed by doctor	4.0	10.9	21.4	1.0	3.3	3.1	-3.6	-4.6	3.0
Cholesterol lowering medication	1.5	2.3	5.4	-1.8	-0.5	-1.6	0.7	2.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	6.6	-2.6	-0.7	-1.2	0.5	1.6	-1.4
Pain experienced in last month	5.1	8.6	16.5	-0.6	-4.1	-2.4	3.2	3.0	-3.2
Supplements: Calcium	0.3	0.3	0.5	0.1	-0.6	0.5	0.2	-0.7	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.9	0.4	0.1	-0.1	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	-1.3	0.9	0.5	-0.8	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	0.5	-0.6	0.6	0.6	-0.8	0.2
Heart disease (siblings)	6.3	7.8	11.8	1.7	3.3	3.4	-2.6	-2.2	3.1
Alcohol drinker status: Previous	0.4	0.5	2.2	-1.5	-0.4	0.3	-0.5	0.1	-0.1
Pack years of smoking	0.3	0.5	1.2	0.9	-1.1	0.1	0.7	-0.0	0.8
Impedance of whole body	7.4	37.6	62.6	-2.3	-6.2	-6.2	6.2	7.9	-6.5
Leg fat mass (left)	1.3	5.1	7.9	-1.4	-2.8	-2.7	2.3	2.1	-1.9
Arm predicted mass (left)	0.2	1.0	3.7	-1.0	-1.9	-0.3	0.4	-1.1	-0.1