Best TWAS P=2.61e-08 · Best GWAS P=1.43e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | LRP4 | 0.68 | 0.00 | lasso | 10 | 0.00 | 5.0e-01 | -2.8 | -5.3 | 1.3e-07 | -0.67 | 0.03 | 0.11 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | ATG13 | 0.13 | 0.07 | enet | 16 | 0.07 | 2.1e-03 | 5.8 | -5.3 | 1.0e-07 | -0.81 | 0.04 | 0.78 | FALSE |
| 3 | GTEx | Esophagus Mucosa | C11orf49 | 0.19 | 0.05 | enet | 21 | 0.12 | 3.2e-08 | -2.8 | -5.1 | 2.8e-07 | -0.64 | 0.14 | 0.83 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ATG13 | 0.12 | 0.08 | enet | 16 | 0.04 | 1.2e-03 | 5.6 | -5.4 | 7.2e-08 | -0.93 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ATG13 | 0.08 | 0.05 | lasso | 4 | 0.05 | 5.1e-05 | 5.9 | -5.6 | 2.6e-08 | -0.96 | 0.04 | 0.95 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PACSIN3 | 0.11 | 0.00 | bslmm | 292 | 0.04 | 1.8e-06 | -3.0 | 5.3 | 1.3e-07 | 0.52 | 0.08 | 0.34 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MDK | 0.03 | 0.02 | lasso | 3 | 0.02 | 2.3e-03 | 5.6 | -5.5 | 3.3e-08 | -0.94 | 0.01 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HARBI1 | 0.05 | 0.02 | blup | 12 | 0.02 | 1.5e-02 | 5.5 | 5.3 | 1.2e-07 | 0.96 | 0.01 | 0.74 | FALSE |