Hub : Genes

LRP4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0210	8.1e-06	0.046	0.037	0.020	0.036	0.042	2.4e-06	2.4e-05	1.5e-03	2.8e-05	6.6e-06
2	GTEx	Artery Tibial	0.0621	0.0340	9.2e-03	-0.004	NA	-0.003	NA	-0.003	9.9e-01	NA	6.4e-01	NA	6.4e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.6810	0.0920	2.9e-03	-0.003	NA	-0.009	NA	-0.005	4.2e-01	NA	8.8e-01	NA	5.0e-01
4	GTEx	Nerve Tibial	0.2800	0.0633	0.0e+00	0.235	NA	0.295	NA	0.288	1.2e-16	NA	3.5e-21	NA	1.1e-20
5	GTEx	Pancreas	0.1090	0.0430	1.9e-06	0.097	NA	0.139	NA	0.125	6.9e-05	NA	1.8e-06	NA	6.3e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1330	0.0560	1.2e-03	0.004	NA	0.016	NA	0.018	1.8e-01	NA	4.3e-02	NA	3.5e-02
7	GTEx	Spleen	0.1490	0.0830	7.2e-03	0.141	NA	0.059	NA	0.117	1.9e-04	NA	1.3e-02	NA	6.5e-04
8	GTEx	Testis	0.1670	0.0760	8.0e-03	0.005	NA	-0.006	NA	-0.006	1.9e-01	NA	7.8e-01	NA	7.8e-01
9	ROSMAP	Brain Pre-frontal Cortex	0.0382	0.0174	7.3e-06	0.058	0.051	0.051	0.050	0.049	6.2e-08	3.5e-07	3.9e-07	4.3e-07	6.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.7	1.1	1.9	1.0	0.7	-1.4	1.4	-1.3	1.4	-0.6	0.3	0.8
Bipolar Disorder or Schizophrenia	2.7	6.6	24.3	1.6	-0.3	-4.9	2.3	-2.3	2.7	-3.8	-0.5	-0.2
Depressed Affect (Nagel 2018)	10.1	21.3	45.6	-6.8	6.3	0.2	-2.9	5.5	-0.5	4.0	4.5	-5.5
Depression (Nagel 2018)	5.4	8.2	17.2	-3.5	4.1	0.5	-1.7	2.7	0.1	3.4	3.7	-2.9
Intelligence (Savage-Jansen 2018)	2.1	6.4	20.2	-1.5	3.9	2.0	1.0	0.6	1.5	4.5	3.3	1.2
Neuroticism (Nagel 2018)	6.8	16.1	31.9	-5.7	4.9	0.6	-2.9	5.2	-0.7	3.5	4.1	-4.9
Schizophrenia (2018)	3.4	7.1	27.9	1.3	-1.0	-5.3	1.8	-1.9	2.4	-4.3	-0.9	-0.9
Schizophrenia vs Biploar Disorder	5.1	6.7	22.1	2.0	-1.8	-4.7	2.4	-2.5	2.0	-3.8	-1.0	0.2
Worry (Nagel 2018)	2.5	5.2	10.6	-3.0	2.9	-0.3	-1.1	3.3	0.0	1.8	2.8	-2.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	1.0	-0.5	-1.2	0.9	-0.0	-0.4	-1.4	-0.1	-0.0
Alzheimer’s Disease (in father)	0.6	0.6	2.1	-0.0	1.2	0.4	0.7	-0.7	0.1	1.4	0.5	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	0.6	0.8	-0.5	1.0	0.2	0.8	-0.1	0.4	0.0
Crohns Disease (2017)	0.3	0.7	1.7	-0.2	-1.2	0.7	-1.3	0.4	0.4	-0.8	-0.5	-1.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	-0.1	-0.8	-0.0	-0.5	0.1	0.1	-0.5	0.4	-0.6
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.3	-0.7	-0.9	0.2	-0.0	-0.2	-0.9	0.7	-0.1
Major Depression (MDD)	1.4	1.7	4.6	-1.2	1.4	-1.4	-0.6	1.0	1.0	-0.6	2.1	-1.6
Reaction Time	10.0	19.1	29.2	5.1	-4.1	-4.9	4.3	-4.9	3.0	-5.4	-3.8	3.1
Verbal and Numeric Reasoning (VNR)	2.7	6.4	20.0	-1.9	4.1	1.4	0.7	0.9	1.8	4.5	3.3	0.6
Breast Cancer	0.5	1.2	3.4	-1.4	1.4	0.1	-0.4	1.8	-1.5	0.2	0.1	-1.0
Ovarian Cancer	1.0	1.3	4.6	0.8	0.1	2.2	0.4	-0.7	0.1	1.5	-0.3	1.9
Prostate Cancer	0.9	1.2	3.8	-1.1	0.6	2.0	-0.9	1.7	-0.2	0.9	-0.8	0.1
Age at First Birth	0.7	1.0	2.5	-1.1	0.5	1.2	-0.9	1.1	-0.6	1.6	1.1	-0.7
Bipolar Disorder (2011)	0.9	0.8	1.7	1.3	-0.1	-0.7	1.2	-1.0	1.2	-0.8	-0.3	1.0
Body Mass Index (BMI) (2010)	1.4	2.0	9.2	-0.3	-1.9	-0.3	-1.5	0.4	-3.0	-1.0	-0.2	-1.2
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.3	-0.2	-0.4	-0.7	0.2	-0.1	-0.7	-0.2	-0.6
Crohns Disease (2012)	0.4	0.6	3.0	0.4	-1.0	-0.3	-0.6	-0.2	0.1	-1.7	0.2	-0.7
Mean Putamen Volume	2.1	2.4	9.8	1.5	-1.9	-1.8	0.8	-1.0	-0.1	-3.1	-1.3	0.2
Fasting Glucose	5.2	6.2	19.0	2.3	0.3	-0.5	3.1	-4.4	1.8	0.6	-0.7	4.1
HbA1C	0.5	0.6	2.0	-0.3	0.8	0.5	0.4	-0.4	1.2	1.4	0.0	0.6
HDL Cholesterol	13.7	22.9	60.0	4.1	2.2	0.4	6.9	-5.7	5.3	3.3	-2.5	7.7
LDL Cholesterol	2.8	4.4	10.7	-1.1	0.1	3.3	-2.5	3.0	-2.3	2.4	0.4	-1.0
Lupus	1.5	2.3	9.3	-0.5	1.9	1.3	1.0	-0.8	1.5	3.0	-0.1	1.4
Neuroticism (2016)	5.5	8.0	14.9	-3.6	3.9	1.0	-1.9	3.0	0.5	3.4	3.2	-2.8
Primary Biliary Cirrhosis	2.9	4.1	9.4	1.7	0.2	-2.8	2.6	-2.6	3.1	-1.4	-0.3	1.1
Rheumatoid Arthritis	1.4	2.0	5.9	-0.6	0.2	2.4	-1.6	1.5	-2.4	-0.0	0.9	-0.1
Schizophrenia (2014)	4.3	9.5	34.5	2.1	-0.3	-5.9	3.2	-3.0	3.1	-4.3	-0.1	0.1
Triglycerides	4.2	6.9	15.8	-2.6	0.0	1.8	-3.2	4.0	-3.5	0.2	2.1	-3.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.0	1.2	-1.2	-0.9	1.4	-1.4	-0.3	-1.1	-0.3	1.3
Ulcerative Colitis	0.5	0.7	2.5	-0.3	-0.4	-0.1	-0.4	0.7	-1.6	-0.9	1.3	-0.4
Blood Eosinophil Count	0.2	1.4	6.0	1.1	-0.0	1.3	0.5	-0.3	-2.4	-0.5	-1.5	0.9
Blood Platelet Count	2.6	29.8	121.0	-0.4	5.8	-6.8	6.3	-4.9	11.0	1.3	0.3	1.5
Blood Red Count	0.3	3.0	12.0	0.5	-0.2	1.6	1.0	-0.8	-1.7	1.4	-3.5	2.4
Blood White Count	0.9	6.7	44.8	0.3	-1.8	0.4	-1.7	1.0	-6.7	-2.6	-0.3	-1.0
Heel T-Score	18.5	147.5	295.8	15.5	-8.1	-8.7	13.5	-17.2	8.2	-9.1	-11.6	13.6
BMI	1.6	9.4	29.6	0.5	-3.9	-1.2	-2.8	0.4	-4.9	-5.4	-0.2	-2.5
Height	2.2	42.5	169.0	2.5	3.9	-3.5	8.4	-6.9	13.0	2.3	-3.8	6.5
Waist Hip Ratio (WHR)	0.7	3.2	11.5	-0.3	2.6	0.2	2.2	-1.1	0.8	3.4	0.9	1.8
Systolic Blood Pressure	6.3	31.6	72.2	-8.0	7.4	-3.5	-2.5	5.7	3.2	2.2	5.2	-8.5
Smoking Status	2.4	5.8	17.5	1.2	1.3	-4.2	3.2	-2.8	3.2	-1.4	-0.6	1.1
Allergy or Eczema	0.1	0.2	1.0	-0.5	0.6	0.3	0.2	1.0	-0.5	-0.3	0.3	0.1
Cardiovascular Disease	3.3	11.0	40.2	-3.7	0.8	-3.6	-2.6	3.8	-0.8	-2.7	1.3	-6.3
Hypothyroidism (self reported)	0.6	1.3	4.7	-0.6	-0.0	-2.2	0.4	-1.1	-1.4	-1.4	-0.6	-1.0
Respiratory disease	1.2	2.7	7.1	-2.5	2.7	-0.1	-0.6	1.7	0.4	1.6	1.5	-1.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	7.1	-0.2	-0.4	-0.0	-0.8	0.7	-2.7	-1.1	-0.2	-0.4
Lung FEV1/FVC ratio	0.4	1.9	7.0	1.4	-1.6	2.6	-0.6	0.3	-1.3	0.4	-1.3	1.4
Lung FVC	1.4	6.9	12.8	3.6	-1.4	-0.6	3.2	-3.3	3.2	-0.5	-1.8	3.5
Neuroticism	7.3	17.5	38.9	-6.2	5.6	0.6	-2.7	4.9	0.5	4.0	3.9	-4.9
Chronotype (morning person)	1.4	3.3	12.2	0.7	-2.5	-2.7	-0.1	-0.3	0.1	-3.5	-1.3	-1.4
Hair Pigment	0.5	13.6	37.8	3.7	1.0	0.4	5.1	-5.2	3.0	1.8	-2.0	6.2
Tanning	0.3	3.8	10.5	1.3	-0.4	-2.6	2.2	-1.1	3.2	-2.4	-1.6	0.8
Hand grip strength (left)	2.1	5.5	24.5	1.2	0.4	-2.7	2.8	-2.0	4.9	-0.0	-1.7	1.2
Number of treatments/medications taken	2.6	4.7	11.2	-2.7	1.0	0.9	-2.8	2.8	-0.7	1.5	1.9	-3.4
Average weekly spirits intake	0.3	0.4	1.5	0.1	-0.6	-0.7	0.1	-0.8	0.6	0.4	-1.2	-0.3
Sensitivity / hurt feelings	3.0	5.1	11.6	-2.4	0.1	2.8	-3.3	3.4	-1.2	1.3	0.9	-2.5
Frequency of depressed mood in last 2 weeks	5.8	8.2	14.1	-3.5	3.8	1.0	-1.8	3.1	-0.1	3.5	3.5	-2.9
Hearing difficulty/problems: Yes	1.0	1.5	5.1	-0.8	2.3	1.6	0.1	-0.0	-0.3	1.9	1.1	0.3
Relative age of first facial hair	0.8	1.6	3.3	1.2	0.4	-0.5	1.8	-1.6	1.8	-0.1	-1.1	1.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.8	0.2	0.2	-1.0	0.7	-1.1	2.2	0.8	0.9	-0.4
Ever used hormone-replacement therapy (HRT)	2.4	3.1	6.1	-1.8	0.5	1.5	-2.5	2.0	-2.1	1.2	1.4	-2.1
Ever had hysterectomy (womb removed)	2.6	2.9	6.6	-0.9	0.9	2.6	-1.5	1.5	-2.5	2.3	1.4	-0.3
Systolic blood pressure, automated reading	4.7	13.7	39.1	-5.3	4.3	-2.7	-2.4	3.2	1.6	0.9	3.5	-6.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.7	1.0	-2.2	-1.1	-0.2	-0.3	-1.4	-1.9	-2.1	-0.2
Angina	2.4	3.2	9.2	-1.4	1.2	1.0	-1.5	2.1	-3.0	0.8	2.1	-1.6
Medication for hormone replacement therapy	1.6	1.8	4.7	0.8	0.7	-1.5	1.4	-2.0	2.2	-0.1	1.0	0.9
Vitamin and mineral supplements	0.2	0.3	0.6	-0.4	0.7	0.1	-0.3	0.8	-0.7	0.2	0.7	-0.6
Supplements: Zinc	1.6	1.7	3.8	1.0	-0.5	-1.8	1.4	-1.6	2.0	-1.4	0.3	0.8
Medication: Co-codamol	1.1	1.3	5.1	-0.5	1.6	-0.5	-0.1	0.4	-0.5	1.6	2.2	-0.8
Medication: Metformin	0.9	1.3	3.0	1.2	-1.4	-1.2	0.3	-0.8	-1.7	-1.6	-0.9	0.1
Diabetes (father)	0.8	1.0	1.8	-0.2	-1.3	1.3	-1.2	0.8	-1.3	-0.3	-1.1	-0.6
Diabetes (mother)	0.5	0.7	2.1	-0.7	0.9	1.4	-0.3	0.4	-0.9	1.0	0.3	0.6
Severe depression (siblings)	2.9	3.3	6.9	2.0	-1.1	-0.1	1.9	-1.8	2.6	-0.8	-2.1	2.3
Pack years adult smoking proportion	1.4	2.2	7.2	-0.1	1.1	-2.7	1.2	-1.3	1.8	-1.3	1.4	-0.9
Impedance of leg (right)	0.9	4.5	15.2	-1.6	3.9	0.5	0.6	2.2	-1.7	2.7	2.6	-0.1
Leg fat-free mass (left)	1.5	7.8	16.5	2.2	-2.7	-2.0	1.8	-3.8	4.1	-2.4	-3.3	1.6
Trunk fat percentage	1.5	6.1	30.5	-0.6	-1.8	-0.8	-2.3	1.0	-5.5	-2.8	0.5	-2.4
Hand grip strength (right)	1.1	3.0	13.6	0.1	1.0	-2.2	2.0	-1.2	3.7	0.6	-1.5	0.3
Townsend deprivation index at recruitment	1.6	2.2	7.7	-1.2	1.7	-1.1	0.3	0.5	2.8	1.4	1.4	-1.5
Current tobacco smoking	2.2	3.6	9.8	-0.9	3.1	-2.8	2.1	-0.9	2.7	0.6	0.8	-0.2
Average weekly fortified wine intake	0.5	0.5	2.1	-0.7	0.7	0.6	-0.5	0.4	-0.8	0.5	1.4	-0.3
Maternal smoking around birth	1.8	2.6	12.1	-0.9	0.8	-3.5	0.6	-0.1	0.9	-1.9	1.3	-1.8
Fed-up feelings	10.8	19.6	41.5	-6.4	5.7	1.3	-3.6	4.9	-1.1	4.2	4.2	-5.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	9.1	-2.7	3.0	0.7	-1.4	1.9	1.4	2.9	2.0	-2.4
Relative age voice broke	1.2	1.8	3.3	1.8	-0.7	-0.0	1.5	-1.8	1.2	-0.4	-1.3	1.8
Taking other prescription medications	0.2	0.4	1.4	0.1	0.2	-1.2	0.6	-1.0	-0.1	0.1	0.5	-0.4
Age when periods started (menarche)	0.7	1.7	5.7	0.2	0.4	1.9	0.7	1.0	1.1	2.4	-1.0	1.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	6.7	-1.4	1.7	0.3	-1.0	1.4	-0.6	1.0	2.6	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	13.3	30.2	60.2	7.0	-4.0	-3.7	5.8	-7.8	4.3	-4.1	-5.2	6.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	0.5	0.3	-0.2	0.5	-0.0	0.5	-0.2	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	2.1	-0.7	0.4	0.2	-0.7	0.4	-0.3	0.1	1.4	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	1.1	0.2	0.2	0.7	0.1	-0.1	-0.4	0.3	1.0	0.1
High blood pressure	6.9	19.3	64.0	-5.4	1.7	-2.0	-4.5	6.2	-2.4	-1.5	2.8	-8.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.2	-0.4	0.5	-0.2	0.1	1.1	-0.5	-0.2	0.7	-0.4
Multivitamins +/- minerals	0.4	0.5	1.3	-1.1	1.2	0.2	0.0	0.4	0.9	1.1	0.3	-0.3
Stomach or abdominal pain in last month	0.7	0.9	1.7	1.3	-0.4	-0.5	1.2	-1.2	1.0	-0.3	-1.2	0.9
Supplements: Glucosamine	1.9	2.5	4.6	2.0	-1.2	-0.0	1.3	-2.1	1.4	-1.1	-1.8	2.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	0.0	1.1	0.9	0.5	-0.7	-0.8	1.4	0.0	1.2
Medication: Atenolol	1.3	1.6	6.1	1.4	-0.8	-2.5	1.1	-0.4	0.8	-1.8	-0.3	-0.6
Medication: Levothyroxine sodium	0.6	1.0	3.3	-0.8	-0.5	-0.6	-1.2	0.3	-1.8	-0.5	-0.2	-1.7
Sitting height	2.9	20.5	84.5	2.2	0.8	-4.2	5.4	-5.3	9.2	-0.9	-2.7	3.3
Chronic bronchitis/emphysema (father)	0.9	1.1	3.5	0.1	0.7	-1.9	1.1	-0.9	1.7	-0.3	0.5	-0.4
High blood pressure (mother)	2.1	3.0	7.1	-2.5	1.0	0.9	-2.3	2.5	-0.1	0.4	0.1	-2.7
Body mass index (BMI)	1.4	5.8	18.0	0.2	-3.2	-0.6	-2.5	0.3	-4.2	-3.4	-0.4	-2.3
Impedance of leg (left)	1.0	4.7	17.0	-1.8	4.1	0.3	0.7	2.1	-1.8	2.5	2.7	-0.1
Leg predicted mass (left)	1.4	7.6	15.6	2.2	-2.8	-1.9	1.7	-3.8	3.9	-2.4	-3.4	1.6
Trunk fat mass	0.7	3.1	9.9	0.2	-2.0	-1.3	-1.1	-0.3	-3.1	-3.0	-0.6	-1.4
Waist circumference	0.6	2.1	10.4	-0.5	-1.2	0.2	-1.7	0.3	-3.2	-1.0	0.3	-1.5
Number of incorrect matches in round	3.3	5.4	11.9	3.2	-2.7	1.0	1.6	-2.2	-1.1	-1.2	-2.8	3.5
Past tobacco smoking	1.1	2.0	8.1	-0.1	-0.5	2.9	-1.1	1.7	-1.9	1.3	-0.4	0.4
Alcohol usually taken with meals	1.9	3.1	10.6	-0.8	0.9	3.2	-0.8	1.0	-2.6	2.4	-0.6	1.2
Nervous feelings	2.2	4.0	14.1	-2.2	1.1	0.7	-1.9	3.8	-0.9	0.7	1.9	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.9	6.4	-1.9	2.5	-0.4	-0.4	1.8	0.9	1.6	2.1	-2.0
Hearing difficulty/problems with background noise	7.7	12.3	22.6	-4.8	3.8	2.3	-3.0	4.0	-1.5	3.7	3.6	-3.8
Hair/balding pattern: Pattern 2	1.6	2.1	6.6	1.0	-0.0	-1.7	1.9	-1.8	2.6	-0.3	-0.7	1.0
Had menopause	0.3	0.4	1.7	0.0	1.3	-0.7	0.7	-0.7	0.6	0.4	0.4	0.2
Had other major operations	0.7	0.9	2.6	-0.2	1.2	1.2	0.8	0.1	-0.6	1.6	-0.2	1.2
Forced vital capacity (FVC)	3.4	12.9	36.8	3.1	0.3	-0.7	4.6	-4.3	6.1	1.6	-2.0	4.8
Heel bone mineral density (BMD) T-score, automated (right)	14.9	34.2	64.0	7.7	-4.4	-3.4	6.3	-8.0	4.7	-3.9	-5.6	6.6
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.9	1.8	-0.4	-1.8	2.5	-2.3	2.6	-0.6	-1.5	1.5
Qualifications: None of the above	0.5	1.0	2.8	-1.0	1.1	-1.7	0.2	0.9	-0.4	-0.6	0.5	-1.7
Financial difficulties in last 2 years	0.6	0.8	2.7	-0.8	0.8	-0.5	-0.4	0.5	1.3	0.7	0.5	-1.7
Mouth/teeth dental problems	1.8	2.7	12.7	-0.9	1.1	2.4	-1.1	0.3	1.5	3.6	0.5	-0.0
Heart attack	0.4	0.6	2.2	-0.8	1.5	-0.7	0.5	-0.2	0.5	1.0	0.3	-0.5
Allergy	0.1	0.3	0.9	0.8	-1.0	0.1	-0.2	-0.8	0.4	-0.2	-0.5	0.3
Pain all over the body in last month	0.2	0.2	0.6	-0.6	0.6	-0.8	-0.1	-0.4	0.0	-0.0	0.6	-0.7
Diabetes (self-reported)	0.3	0.4	1.9	0.2	-0.7	-0.2	-0.7	0.2	-1.4	-0.7	-0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	4.3	5.7	12.6	-3.5	2.7	0.7	-1.7	2.5	-2.2	1.8	2.9	-2.2
Medication: Ramipril	1.0	1.3	4.3	-0.5	-0.4	-1.4	-0.6	0.8	0.9	-1.8	0.1	-2.1
Medication: Simvastatin	1.2	1.8	5.2	-1.9	0.5	-0.7	-1.4	1.3	-1.3	0.5	0.7	-2.3
Fluid intelligence score	2.3	4.8	13.7	-1.0	3.6	1.1	1.1	0.5	1.7	3.7	2.9	1.2
Illnesses of siblings	1.6	2.3	7.3	0.3	0.5	2.7	0.2	-0.3	0.8	2.6	-0.8	2.2
Neuroticism score	5.4	11.3	23.1	-4.8	4.8	0.5	-2.1	4.0	0.9	3.5	2.8	-3.9
Weight	0.5	2.4	5.4	1.1	-1.9	-1.6	0.5	-2.2	0.7	-2.3	-1.8	0.2
Impedance of arm (right)	0.1	0.6	2.8	-0.1	0.3	-0.8	0.5	0.9	-1.7	-0.3	0.7	-0.1
Arm fat percentage (right)	2.1	8.1	32.4	0.1	-3.2	-0.8	-2.6	0.8	-5.7	-3.9	-0.0	-2.6
Trunk fat-free mass	2.9	16.4	57.3	3.2	-1.4	-1.9	4.1	-5.2	7.6	-1.0	-3.9	3.7
Hip circumference	0.9	4.1	10.4	-1.1	-1.6	0.8	-3.2	1.4	-3.2	-1.5	0.7	-2.6
Time employed in main current job	2.2	2.5	6.9	2.6	-1.4	-0.1	2.0	-1.7	0.8	-0.7	-0.5	2.4
Alcohol intake versus 10 years previously	0.9	1.3	2.9	1.5	-1.7	-0.5	0.4	-0.4	-1.5	-1.4	-1.3	0.7
Father’s age at death	1.5	2.0	5.4	-0.7	-0.3	1.4	-1.7	2.1	-2.3	0.6	1.1	-1.0
Worrier / anxious feelings	0.2	0.4	1.4	-0.7	0.4	-0.4	-0.3	1.2	0.5	-0.2	0.6	-1.0
Frequency of tiredness / lethargy in last 2 weeks	4.2	6.9	12.9	-3.6	3.0	1.1	-2.0	3.2	0.9	3.0	2.5	-2.9
Falls in the last year	1.8	2.4	7.8	-0.9	1.8	-1.9	0.3	-0.2	2.8	0.1	1.9	-1.6
Hair/balding pattern: Pattern 3	2.2	3.3	7.4	-0.8	-1.2	1.3	-2.7	2.4	-2.4	-0.9	1.4	-2.0
Number of live births	1.7	2.4	6.8	1.4	-0.8	-2.6	1.7	-1.8	0.7	-2.1	-1.0	0.4
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	18.1	2.8	-0.5	1.0	3.2	-2.9	4.2	1.9	-2.3	4.3
Pulse rate	0.6	1.0	2.5	0.4	0.5	0.7	0.5	-1.6	1.0	1.2	-0.6	1.5
Happiness	2.0	2.4	5.4	-2.3	1.9	0.2	-1.3	1.5	0.2	1.0	1.8	-2.1
Noisy workplace	1.6	1.9	3.9	0.8	-0.2	-1.9	1.5	-1.6	1.5	-1.3	-2.0	0.3
Qualifications: A levels/AS levels or equivalent	1.9	4.1	16.3	-1.3	0.8	4.0	-1.9	1.5	-1.4	3.2	0.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	-0.3	-0.5	1.5	-1.0	1.3	-0.4	0.3	-0.4	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.9	2.6	0.7	1.0	-1.0	1.6	-1.2	-0.2	0.2	-0.4	1.1
Asthma	1.8	3.5	7.1	-2.7	1.8	0.7	-1.6	2.3	-0.6	1.5	1.9	-2.4
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	9.4	-0.9	2.0	2.9	-0.4	1.0	-1.0	3.1	0.9	1.1
Medication: Cholesterol lowering	0.5	0.8	2.6	-1.0	0.4	-1.5	-0.3	0.2	0.1	-0.5	0.9	-1.6
Depression (self-reported)	1.2	1.4	4.6	-1.1	1.7	-0.3	0.1	-0.1	2.1	1.4	1.0	-0.8
Medication: Lansoprazole	0.9	1.0	2.5	-0.8	-0.1	0.3	-1.0	1.1	-1.6	0.3	1.6	-1.0
Prospective memory result	2.7	3.3	13.8	0.9	-2.2	-2.7	-0.1	-0.7	1.0	-3.7	-0.2	-1.2
Lung cancer (father)	2.3	2.7	6.1	1.6	0.2	-1.6	2.4	-1.9	2.5	-0.5	-1.3	1.5
Illnesses of mother	0.7	0.9	2.5	1.5	-1.2	0.3	0.7	-1.1	-0.1	0.1	0.5	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.5	25.0	3.4	-0.7	0.8	3.7	-3.5	4.7	1.4	-2.6	5.0
Pulse wave Arterial Stiffness index	0.7	0.8	2.3	-1.5	1.5	-0.2	-0.4	0.7	0.0	0.7	0.6	-1.0
Impedance of arm (left)	0.2	0.9	4.3	-0.7	0.8	-0.7	0.1	1.0	-2.1	-0.0	1.1	-0.3
Arm fat mass (right)	1.0	4.2	12.1	0.6	-3.0	-1.2	-1.5	-0.3	-3.1	-3.5	-0.8	-1.6
Trunk predicted mass	2.8	16.0	56.1	3.2	-1.4	-1.9	4.0	-5.2	7.5	-1.1	-3.8	3.7
Standing height	2.9	28.5	110.2	2.5	2.2	-2.8	6.9	-5.8	10.5	1.4	-3.6	5.6
Length of working week for main job	0.8	0.9	3.3	0.9	-0.0	-0.2	0.9	-1.8	1.5	0.1	-0.4	1.1
Exposure to tobacco smoke at home	0.8	0.9	2.5	-0.0	-1.1	-0.2	-1.2	0.8	-1.1	-1.6	0.0	-1.2
Breastfed as a baby	2.6	3.2	11.4	1.0	0.2	-0.3	1.7	-2.3	3.4	0.3	-1.8	2.2
Tense / ‘highly strung’	0.6	1.1	3.4	-1.1	0.7	-0.6	-0.7	1.8	-0.5	-0.3	0.5	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.8	14.0	-2.3	2.2	-2.2	-0.6	1.3	2.1	0.6	3.7	-2.8
Hair/balding pattern: Pattern 4	2.7	6.5	13.5	-3.7	2.5	0.5	-3.1	2.5	-2.9	1.4	1.8	-3.1
Birth weight of first child	1.4	2.5	8.0	1.2	-0.0	2.4	1.0	-1.1	0.4	1.8	-1.2	2.8
Peak expiratory flow (PEF)	1.1	2.5	9.7	1.0	-0.1	0.7	1.3	-1.2	3.1	1.7	-1.1	2.0
Pulse wave reflection index	0.5	0.7	1.9	-0.9	0.5	-0.3	-0.8	1.0	-1.0	-0.2	0.4	-1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.6	-0.1	1.6	-0.4	1.0	-1.3	1.6	1.3	-0.4	0.5
Loud music exposure frequency	1.1	1.2	3.1	0.6	-1.8	0.5	-0.5	-0.0	-1.6	-1.4	-1.5	-0.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	5.2	-1.7	1.1	2.3	-1.4	1.6	-1.5	1.8	1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	4.2	5.4	26.4	1.0	-3.3	-1.8	-0.4	1.1	-2.0	-5.1	-1.0	-1.1
Blood clot in the leg (DVT)	3.4	4.4	11.4	1.4	2.0	-1.6	3.4	-2.9	1.4	0.6	0.5	3.1
Medication: Paracetamol	0.8	1.4	6.0	-0.6	1.4	1.7	-0.1	0.0	-0.6	2.4	0.1	0.7
Headache pain in last month	1.3	2.3	8.6	-0.4	1.6	2.2	-0.0	1.2	-1.2	2.9	0.4	0.8
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	13.4	2.3	-0.8	1.9	1.5	-1.7	-0.1	0.7	-1.8	3.7
Glaucoma (self-reported)	2.5	2.9	6.9	1.2	1.2	1.5	1.8	-1.3	1.5	2.5	-1.0	2.6
Gout (self-reported)	0.4	0.6	1.9	-0.9	0.5	-1.4	-0.2	0.3	0.4	-0.6	-0.3	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	3.6	-1.1	0.0	-1.3	-0.8	0.2	-1.8	-0.7	0.3	-1.9
Medication: Amlodipine	3.7	5.2	18.1	-2.4	0.8	-2.9	-1.6	2.2	0.2	-1.8	1.9	-4.3
Medication: Ventolin 100micrograms inhaler	1.0	1.2	4.3	-1.3	2.1	-0.5	0.1	0.4	0.1	1.1	1.6	-0.9
Birth weight	1.3	2.9	11.5	0.7	0.9	0.2	1.7	-1.5	3.4	1.6	-1.7	1.7
Chronic bronchitis/emphysema (mother)	1.6	1.9	7.0	0.3	1.1	-2.6	1.9	-1.4	1.3	-1.2	-0.3	0.3
High blood pressure (siblings)	1.1	1.6	4.5	-0.8	-0.1	-2.0	-0.3	0.8	-0.7	-1.9	-0.1	-2.1
Forced vital capacity (FVC), Best measure	4.8	17.4	45.7	4.1	-0.3	-0.8	5.3	-4.8	6.8	0.8	-3.1	5.7
Body fat percentage	1.9	7.4	35.8	-0.8	-1.8	-0.9	-2.6	1.3	-6.0	-3.0	0.7	-2.8
Leg fat percentage (right)	2.2	7.9	38.2	-1.0	-1.4	-0.4	-3.0	2.0	-6.2	-2.5	1.2	-3.1
Arm fat-free mass (right)	1.4	7.2	26.6	1.6	-0.3	-1.5	2.7	-3.8	5.2	-0.6	-2.4	2.3
Exposure to tobacco smoke outside home	1.4	1.9	3.1	-1.3	0.1	0.9	-1.7	1.8	-1.5	-0.8	1.7	-1.5
Comparative body size at age 10	1.2	3.2	12.0	0.5	-2.4	-1.6	-1.1	-1.5	-1.6	-3.5	-1.2	-1.1
Number of full brothers	0.9	1.1	3.2	0.0	-0.3	-1.8	0.4	-0.7	1.8	-1.5	-0.6	-0.8
Worry too long after embarrassment	0.3	0.6	1.6	-0.9	0.6	-0.8	-0.2	0.8	1.3	-0.0	0.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.5	0.1	0.5	-1.0	0.6	-0.5	1.9	0.3	1.1	-0.4
Wheeze or whistling in the chest in last year	0.8	1.4	5.2	-1.0	1.8	-2.3	1.0	-0.3	-0.2	-0.6	0.4	-1.1
Number of children fathered	2.9	3.3	6.7	2.5	-1.9	-1.3	1.4	-1.7	0.0	-2.6	-1.8	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.8	0.1	-0.5	-2.0	-0.2	-0.4	1.0	-1.2	-0.4	-1.0
Age at first live birth	2.0	3.6	13.4	-1.4	1.5	2.8	-1.4	1.3	-0.9	3.7	1.4	-0.3
Pulse wave peak to peak time	0.8	0.9	2.3	1.5	-1.3	0.0	0.8	-0.9	0.6	-0.6	-0.7	1.3
Health satisfaction	0.7	0.9	2.5	-1.3	1.6	-0.8	-0.1	0.7	1.1	0.5	0.1	-1.2
Shortness of breath walking on level ground	2.7	3.2	7.7	-2.4	2.3	-0.3	-1.2	1.7	-0.7	1.1	2.8	-2.1
Qualifications: College or University degree	0.5	1.6	6.2	-1.0	0.9	1.7	-1.1	0.2	0.1	2.5	1.5	-0.3
Eye problems/disorders: None of the above	0.5	0.6	1.0	-0.9	0.8	1.0	-0.7	1.0	-0.2	0.9	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.3	-0.6	0.7	-2.3	0.5	-0.3	-0.0	-1.4	1.7	-1.1
Emphysema/chronic bronchitis	0.4	0.5	1.8	-0.4	0.6	-0.8	0.7	-0.2	1.3	-0.7	-0.5	-0.2
Medication for pain relief, constipation, heartburn	0.6	1.1	3.1	0.8	-0.6	-1.5	0.9	-1.1	1.8	-1.1	-0.5	0.4
Neck or shoulder pain in last month	1.4	2.0	7.7	-1.5	2.8	0.5	-0.1	0.6	0.3	2.5	1.0	-0.5
Medication: Blood pressure	3.6	6.3	24.6	-3.0	1.2	-2.0	-2.3	2.8	-0.0	-0.7	2.2	-5.0
Angina (self-reported)	1.9	2.6	8.6	-1.1	1.1	0.9	-1.3	1.8	-2.9	0.8	1.9	-1.3
Migraine (self-reported)	3.0	3.7	12.2	-0.1	2.4	1.6	1.4	-0.8	2.5	3.5	0.1	2.0
Medication: Ibuprofen	1.8	2.1	8.0	-0.5	1.2	2.8	-0.9	1.2	-0.9	2.4	0.5	0.8
Medication: Allopurinol	0.8	1.1	4.0	-1.3	0.4	-0.7	-1.0	0.8	0.6	-0.3	0.9	-2.0
Medication: Omeprazole	0.4	0.5	1.3	1.1	-1.2	0.4	0.1	-0.7	-0.6	0.1	-1.0	0.4
Medication: Seretide 50 evohaler	0.6	0.7	2.2	0.3	0.4	-1.4	0.9	-0.7	1.5	-0.8	-0.4	-0.4
Mean time to correctly identify matches	12.0	22.9	35.6	5.6	-4.4	-5.2	4.7	-5.2	3.6	-6.0	-4.3	3.4
Heart disease (mother)	0.8	1.0	3.3	0.3	-1.1	-1.6	0.6	-0.1	0.1	-1.8	-1.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.4	-1.4	1.9	-0.2	-0.6	1.1	-1.8	0.8	1.8	-1.7
Whole body fat mass	0.8	3.4	10.8	0.1	-2.1	-1.3	-1.3	-0.2	-3.3	-3.0	-0.6	-1.6
Leg fat mass (right)	0.8	3.1	10.8	-0.0	-1.8	-1.1	-1.5	-0.0	-3.3	-2.7	-0.2	-1.8
Arm predicted mass (right)	1.5	7.6	26.2	1.7	-0.4	-1.5	2.8	-4.0	5.1	-0.6	-2.6	2.5
Pulse rate, automated reading	0.5	1.7	4.6	0.8	0.7	1.1	0.5	-2.1	0.9	2.0	-0.0	1.8
Alcohol intake frequency.	1.0	2.4	9.1	1.1	-0.4	2.0	0.4	-1.0	-3.0	0.7	-1.4	1.9
Comparative height size at age 10	3.4	18.5	50.6	2.9	1.2	-2.9	5.8	-5.6	7.1	-0.2	-3.3	4.6
Number of full sisters	0.7	0.9	1.9	0.8	-0.7	-1.2	0.8	-0.7	1.0	-1.2	-1.4	0.4
Suffer from ‘nerves’	5.5	8.7	17.1	-3.7	4.1	0.8	-1.3	3.2	1.4	3.7	3.6	-2.4
Overall health rating	2.5	5.5	12.4	-3.1	3.5	-1.5	-0.8	1.2	1.0	2.0	2.7	-3.3
Chest pain or discomfort	1.6	2.3	12.5	-1.0	3.5	-1.2	1.4	0.0	1.1	1.2	1.1	-0.2
Had major operations	2.6	3.0	6.9	-2.2	2.0	1.2	-1.2	1.8	-0.1	1.8	2.6	-1.4
Age at last live birth	0.5	0.7	4.1	-0.4	1.0	0.8	0.0	-0.1	0.7	2.0	0.2	0.4
Family relationship satisfaction	0.6	0.8	2.8	-0.7	1.0	-1.2	0.8	-0.5	1.7	-0.4	-0.4	-0.2
Leg pain on walking	1.2	1.5	4.6	-1.1	2.1	-1.0	0.8	0.2	1.1	1.4	1.4	-1.0
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	10.2	3.2	-2.4	0.0	1.3	-1.8	0.2	-1.4	-2.3	2.5
Commuting to job workplace: Car/motor vehicle	2.9	3.3	8.2	2.8	-1.6	0.1	1.9	-2.0	0.3	-1.2	-1.5	2.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.4	0.1	-0.5	-0.4	0.1	-0.2	-1.5	-0.4	-0.2	0.3
Medication: Aspirin	0.9	1.1	4.0	-1.1	0.8	-1.5	-0.3	0.4	-0.2	-0.8	1.1	-2.0
Supplements: Vitamin C	1.1	1.3	3.4	1.7	-1.0	0.3	1.3	-1.1	-0.3	-0.8	-0.6	1.8
Knee pain experienced in last month	0.9	1.4	3.2	1.4	0.5	1.0	1.3	-0.8	1.6	0.6	-0.4	1.8
Hypertension (Self-reported)	6.6	18.3	62.7	-5.0	1.5	-2.5	-4.2	5.7	-2.3	-2.2	2.8	-7.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	0.7	0.0	0.8	1.0	-0.1	0.8	0.5	-1.4	1.5
Illnesses of father: Heart disease	0.9	1.3	3.6	-1.7	0.8	-0.3	-1.2	1.1	0.5	0.3	1.1	-1.9
Illnesses of siblings: Diabetes	0.7	0.9	2.2	0.3	-1.4	0.2	-0.8	0.2	-1.5	-1.5	-0.3	-0.5
Smoking status: Previous	0.7	1.1	2.8	1.0	-1.1	-1.4	0.4	-1.4	0.8	-1.7	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.2	20.7	2.3	-0.6	-0.3	3.1	-3.2	4.5	0.6	-2.6	3.5
Whole body fat-free mass	2.1	12.1	38.2	2.8	-1.9	-1.9	3.1	-4.7	6.2	-1.6	-3.7	2.9
Leg fat-free mass (right)	1.5	8.2	18.7	2.2	-2.7	-1.9	1.8	-4.0	4.3	-2.3	-3.4	1.8
Arm fat percentage (left)	2.3	9.0	37.0	-0.3	-3.1	-0.7	-3.1	1.1	-6.1	-3.8	0.2	-2.9
Average weekly red wine intake	0.1	0.2	0.6	0.1	-0.6	0.5	-0.7	0.1	0.6	0.3	-0.5	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.0	-0.5	-0.5	-0.5	0.7	0.9	-0.8	0.8	-0.5
Mood swings	4.4	7.9	16.7	-3.8	3.2	-0.2	-2.1	4.1	0.0	1.7	2.6	-4.0
Loneliness, isolation	5.1	7.0	16.9	-3.6	4.1	-0.2	-0.7	2.5	2.1	3.1	2.6	-2.4
Long-standing illness, disability or infirmity	1.0	1.5	4.8	0.1	1.0	-2.2	1.3	-1.2	1.8	-0.3	1.0	-0.5
Ever had bowel cancer screening	0.6	0.8	1.7	1.1	-1.1	0.4	0.3	-0.8	-1.2	-0.7	-0.1	1.3
Diabetes diagnosed by doctor	0.2	0.3	1.2	0.6	-0.5	-0.4	0.0	-0.6	-1.1	-0.5	-0.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.9	0.6	-0.7	0.1	0.7	-0.3	-0.4	-0.0	-1.7	1.0
Friendships satisfaction	1.5	1.9	5.9	-1.3	2.4	-1.2	0.8	-0.6	1.8	1.4	1.3	-0.6
Qualifications: nursing, teaching	0.8	1.2	3.8	-1.6	-0.1	0.0	-1.8	1.1	0.0	0.3	0.4	-1.9
Commuting to job workplace: Walk	2.6	2.8	5.8	-2.4	2.3	0.4	-0.9	1.6	0.1	2.0	2.0	-1.6
Eye problems/disorders: Cataract	0.3	0.4	1.4	-0.1	0.0	-1.2	0.1	-1.0	-0.3	-0.6	0.3	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.4	0.9	-1.4	-0.9	0.5	-0.7	0.8	-2.1	-0.2	0.0
Medication for cholesterol	1.4	2.2	7.6	1.3	0.3	1.5	1.4	-1.5	0.5	1.7	-0.7	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	9.8	1.8	-3.1	-1.1	0.2	-0.9	-0.1	-3.1	-1.2	0.2
Back pain experienced in last month	3.0	4.4	12.8	-2.0	2.8	2.2	-1.2	2.2	-0.5	3.6	1.6	-1.1
Mineral and other dietary supplements	0.2	0.3	0.7	0.0	0.9	-0.9	0.6	-0.4	0.6	0.3	0.2	0.1
Breast cancer (self-reported)	0.3	0.4	1.2	0.9	-1.1	-0.3	0.4	-0.4	-0.2	-0.6	-0.9	0.2
Asthma (self-reported)	1.5	3.1	6.5	-2.5	1.9	0.5	-1.4	2.1	-0.4	1.4	1.9	-2.3
Osteoporosis (self-reported)	4.2	5.2	9.5	-2.7	2.0	1.9	-1.9	2.4	-1.2	3.1	2.8	-1.7
Osteoarthritis (self-reported)	0.6	0.8	2.1	-0.9	1.0	0.6	-0.4	0.5	1.4	1.4	0.3	-0.7
Medication: Aspirin	0.6	0.8	2.7	-0.5	0.1	-1.6	-0.1	0.1	0.2	-1.2	0.4	-1.6
Medication: Gliclazide	0.8	0.9	2.7	0.7	-0.6	-1.6	0.4	-1.0	-0.6	-1.7	0.4	-0.1
Illnesses of father: None of the above (group 1)	1.9	2.4	8.6	2.0	-0.8	0.6	1.6	-1.8	-0.2	-0.6	-1.3	2.9
Smoking status: Current	2.2	3.5	10.3	-0.9	3.2	-2.8	2.1	-0.9	2.5	0.4	0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	8.3	2.9	-2.1	0.7	1.4	-1.1	-0.2	-1.2	-1.5	2.5
Whole body water mass	2.1	12.0	38.3	2.7	-1.8	-1.8	3.2	-4.7	6.2	-1.4	-3.7	2.9
Leg predicted mass (right)	1.6	8.4	18.4	2.3	-2.8	-1.9	1.9	-4.0	4.3	-2.4	-3.5	1.8
Arm fat mass (left)	0.9	3.9	11.1	0.6	-2.8	-1.1	-1.4	-0.5	-3.1	-3.3	-0.8	-1.4
Number of self-reported non-cancer illnesses	4.4	7.6	16.1	-4.0	3.7	-0.5	-1.4	2.6	0.5	2.6	3.1	-3.6
Average weekly champagne plus white wine intake	0.4	0.6	1.9	0.8	0.5	0.1	1.2	-0.2	-0.4	-0.7	0.2	1.4
Miserableness	8.7	15.1	31.2	-5.6	4.4	0.8	-3.2	5.5	-1.1	3.0	3.0	-5.0
Guilty feelings	3.3	4.9	11.1	-2.5	3.3	-2.2	-0.3	1.5	2.3	0.6	2.2	-3.0
Wears glasses or contact lenses	0.4	0.4	1.3	0.5	-0.4	-0.8	-0.0	-0.4	0.8	-0.9	-1.1	-0.4
Ever taken oral contraceptive pill	2.0	2.2	7.8	-0.4	0.8	2.8	-0.6	0.5	1.5	2.8	0.1	0.9
Hearing aid user	0.9	1.0	2.9	0.2	-0.7	-0.6	-0.7	0.3	-1.7	-1.7	0.6	-1.0
Mother’s age at death	0.9	1.1	4.0	-0.1	-0.3	2.0	-1.2	1.4	-1.1	0.8	0.5	-0.2
Financial situation satisfaction	0.3	0.4	1.5	-0.6	0.7	0.0	0.3	-0.3	1.2	0.9	0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	0.2	0.1	-0.8	0.6	0.1	-0.6	-0.4	-1.1	0.1
Commuting to job workplace: Public transport	0.7	0.8	1.9	-1.3	0.5	-0.1	-0.9	0.9	0.6	1.0	0.8	-1.4
Eye problems/disorders: Glaucoma	3.1	3.7	8.5	1.0	1.8	0.8	2.3	-1.8	1.9	2.7	-0.4	2.9
Medication: Blood pressure	3.1	6.0	16.5	-2.3	-0.3	-1.3	-2.4	3.6	-2.1	-2.6	0.7	-4.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.9	-1.0	1.4	-0.2	-0.4	0.4	0.8	1.7	0.0	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.2	5.0	1.3	-2.2	0.5	-0.5	-0.4	-0.0	-1.6	-1.1	0.4
High cholesterol (Self-reported)	1.2	2.1	6.6	-2.1	0.8	-1.8	-0.9	1.3	-0.8	-0.5	1.1	-2.6
Medication: Bendroflumethiazide	2.9	4.4	13.1	-2.7	0.9	-1.2	-2.0	3.3	-1.1	-0.9	0.5	-3.6
Medication: Paracetamol	0.6	0.9	3.6	-0.2	1.1	1.4	0.1	-0.5	-0.3	1.9	0.1	1.1
Medication: Lisinopril	3.6	4.6	10.8	-2.7	1.5	-0.6	-1.9	3.0	-1.8	0.0	2.3	-3.3
Medication: Atorvastatin	0.5	0.6	1.5	0.4	-1.1	-1.2	-0.2	-0.4	0.4	-1.1	-0.3	-1.0
Illnesses of father: High blood pressure	1.1	1.3	4.8	-0.6	0.4	-2.2	0.5	0.8	0.9	-1.4	0.2	-1.6
Alcohol drinker status: Never	1.0	1.3	9.1	-0.1	0.3	0.8	-0.7	0.5	-3.0	-0.0	0.8	0.2
Ever smoked	0.9	1.6	5.9	-0.5	1.2	-2.4	1.2	-1.3	1.9	-0.6	0.4	-0.2
Basal metabolic rate	1.6	8.8	23.3	2.4	-2.0	-1.8	2.5	-4.1	4.8	-1.9	-3.3	2.3
Leg fat percentage (left)	2.2	7.9	37.8	-0.8	-1.6	-0.6	-2.8	1.6	-6.2	-2.9	1.1	-3.1
Arm fat-free mass (left)	1.4	6.9	24.7	1.9	-0.9	-1.4	2.5	-3.6	5.0	-0.8	-2.6	2.1
Number of operations (self-reported)	0.5	0.8	1.8	0.0	0.5	1.3	0.5	-0.1	-0.9	0.9	1.3	1.1
Average weekly beer plus cider intake	3.0	4.3	10.9	1.6	0.2	-3.2	2.5	-2.2	3.3	-1.7	0.1	0.8
Irritability	0.5	0.9	2.3	-1.0	1.5	0.6	-0.4	1.0	0.2	1.5	0.8	-0.7
Risk taking	1.9	2.8	10.7	1.5	-0.8	-1.6	1.6	-2.1	3.3	-0.7	-0.8	0.9
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.6	-1.8	1.2	0.5	-1.5	1.3	-0.3	0.8	1.9	-1.5
Fractured/broken bones in last 5 years	1.7	2.2	5.9	-1.6	1.1	0.8	-0.9	2.0	0.9	1.2	2.4	-1.5
Age started oral contraceptive pill	0.6	0.7	1.8	-1.1	0.0	0.9	-0.8	1.3	-1.4	0.2	-0.1	-0.4
Diastolic blood pressure, automated reading	2.1	6.7	22.6	-3.5	2.7	-2.4	-1.5	2.4	0.1	-0.2	2.0	-4.8
Ever depressed for a whole week	0.7	0.8	3.6	0.6	-0.5	-1.2	0.8	-0.9	1.9	-0.3	-0.1	0.3
Unable to work because of sickness or disability	1.5	2.0	10.2	-0.3	1.2	-1.9	0.8	-0.9	3.2	-0.3	0.4	-0.8
Commuting to job workplace: Cycle	0.5	0.6	1.7	-0.0	-1.3	0.1	-1.2	0.5	-0.5	-0.3	-1.0	-0.8
Myopia	2.2	3.3	9.3	1.0	1.4	-2.0	2.4	-1.9	3.0	-0.5	0.6	1.7
Vascular/heart problems diagnosed by doctor	6.3	17.2	57.2	5.2	-2.0	2.2	4.0	-5.6	2.2	1.4	-2.9	7.6
Cholesterol lowering medication	1.6	2.4	7.3	-1.8	0.1	0.0	-1.7	2.0	-2.7	0.2	-0.1	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	1.1	-0.9	0.7	0.0	-0.5	-1.2	0.1	-0.2	0.5
Pain experienced in last month	2.4	4.0	8.6	1.9	-2.4	-2.4	1.3	-2.3	1.6	-2.9	-1.5	0.7
Supplements: Calcium	1.0	1.1	3.9	-1.1	1.1	0.6	-0.2	0.4	0.9	1.6	2.0	-0.3
Basal cell carcinoma (self-reported)	1.2	1.5	4.7	-1.2	-0.5	-1.0	-1.2	1.2	-0.2	-1.3	1.0	-2.2
Heart attack/myocardial infarction (self-reported)	0.7	1.0	3.4	-0.8	1.8	-1.1	0.9	-0.5	0.9	1.0	0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	12.5	1.7	1.5	-1.8	3.5	-3.0	1.5	0.1	0.2	3.1
Heart disease (siblings)	1.0	1.3	2.4	1.3	-0.6	-1.5	1.5	-1.4	0.6	-1.2	-0.4	0.8
Alcohol drinker status: Previous	1.1	1.3	3.2	-1.5	1.2	-1.1	-0.4	0.4	-0.3	0.6	1.8	-1.6
Pack years of smoking	1.8	2.6	9.0	-0.1	1.2	-3.0	1.3	-1.5	1.9	-1.5	1.5	-0.9
Impedance of whole body	0.6	3.2	7.8	-1.7	2.8	0.1	0.1	2.1	-2.6	1.7	2.0	-0.4
Leg fat mass (left)	0.8	3.2	9.5	0.3	-2.0	-1.5	-1.2	-0.5	-3.1	-3.1	-0.3	-1.5
Arm predicted mass (left)	1.2	6.2	21.9	1.7	-0.8	-1.3	2.4	-3.5	4.7	-0.7	-2.5	2.1