Hub : Genes

LRP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0450 0.0210 8.1e-06 0.046 0.037 0.020 0.036 0.042 2.4e-06 2.4e-05 1.5e-03 2.8e-05 6.6e-06
2 GTEx Artery Tibial 0.0621 0.0340 9.2e-03 -0.004 NA -0.003 NA -0.003 9.9e-01 NA 6.4e-01 NA 6.4e-01
3 GTEx Cells EBV-transformed lymphocytes 0.6810 0.0920 2.9e-03 -0.003 NA -0.009 NA -0.005 4.2e-01 NA 8.8e-01 NA 5.0e-01
4 GTEx Nerve Tibial 0.2800 0.0633 0.0e+00 0.235 NA 0.295 NA 0.288 1.2e-16 NA 3.5e-21 NA 1.1e-20
5 GTEx Pancreas 0.1090 0.0430 1.9e-06 0.097 NA 0.139 NA 0.125 6.9e-05 NA 1.8e-06 NA 6.3e-06
6 GTEx Skin Not Sun Exposed Suprapubic 0.1330 0.0560 1.2e-03 0.004 NA 0.016 NA 0.018 1.8e-01 NA 4.3e-02 NA 3.5e-02
7 GTEx Spleen 0.1490 0.0830 7.2e-03 0.141 NA 0.059 NA 0.117 1.9e-04 NA 1.3e-02 NA 6.5e-04
8 GTEx Testis 0.1670 0.0760 8.0e-03 0.005 NA -0.006 NA -0.006 1.9e-01 NA 7.8e-01 NA 7.8e-01
9 ROSMAP Brain Pre-frontal Cortex 0.0382 0.0174 7.3e-06 0.058 0.051 0.051 0.050 0.049 6.2e-08 3.5e-07 3.9e-07 4.3e-07 6.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.7 1.1 1.9 1.0 0.7 -1.4 1.4 -1.3 1.4 -0.6 0.3 0.8
Bipolar Disorder or Schizophrenia 2.7 6.6 24.3 1.6 -0.3 -4.9 2.3 -2.3 2.7 -3.8 -0.5 -0.2
Depressed Affect (Nagel 2018) 10.1 21.3 45.6 -6.8 6.3 0.2 -2.9 5.5 -0.5 4.0 4.5 -5.5
Depression (Nagel 2018) 5.4 8.2 17.2 -3.5 4.1 0.5 -1.7 2.7 0.1 3.4 3.7 -2.9
Intelligence (Savage-Jansen 2018) 2.1 6.4 20.2 -1.5 3.9 2.0 1.0 0.6 1.5 4.5 3.3 1.2
Neuroticism (Nagel 2018) 6.8 16.1 31.9 -5.7 4.9 0.6 -2.9 5.2 -0.7 3.5 4.1 -4.9
Schizophrenia (2018) 3.4 7.1 27.9 1.3 -1.0 -5.3 1.8 -1.9 2.4 -4.3 -0.9 -0.9
Schizophrenia vs Biploar Disorder 5.1 6.7 22.1 2.0 -1.8 -4.7 2.4 -2.5 2.0 -3.8 -1.0 0.2
Worry (Nagel 2018) 2.5 5.2 10.6 -3.0 2.9 -0.3 -1.1 3.3 0.0 1.8 2.8 -2.5
Alzheimer’s Disease (in mother) 0.5 0.6 1.9 1.0 -0.5 -1.2 0.9 -0.0 -0.4 -1.4 -0.1 -0.0
Alzheimer’s Disease (in father) 0.6 0.6 2.1 -0.0 1.2 0.4 0.7 -0.7 0.1 1.4 0.5 0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 1.0 0.6 0.8 -0.5 1.0 0.2 0.8 -0.1 0.4 0.0
Crohns Disease (2017) 0.3 0.7 1.7 -0.2 -1.2 0.7 -1.3 0.4 0.4 -0.8 -0.5 -1.1
Irritable Bowel Disease (IBD) 0.1 0.2 0.7 -0.1 -0.8 -0.0 -0.5 0.1 0.1 -0.5 0.4 -0.6
Ulcerative Colitis (UC) 0.2 0.3 0.8 0.3 -0.7 -0.9 0.2 -0.0 -0.2 -0.9 0.7 -0.1
Major Depression (MDD) 1.4 1.7 4.6 -1.2 1.4 -1.4 -0.6 1.0 1.0 -0.6 2.1 -1.6
Reaction Time 10.0 19.1 29.2 5.1 -4.1 -4.9 4.3 -4.9 3.0 -5.4 -3.8 3.1
Verbal and Numeric Reasoning (VNR) 2.7 6.4 20.0 -1.9 4.1 1.4 0.7 0.9 1.8 4.5 3.3 0.6
Breast Cancer 0.5 1.2 3.4 -1.4 1.4 0.1 -0.4 1.8 -1.5 0.2 0.1 -1.0
Ovarian Cancer 1.0 1.3 4.6 0.8 0.1 2.2 0.4 -0.7 0.1 1.5 -0.3 1.9
Prostate Cancer 0.9 1.2 3.8 -1.1 0.6 2.0 -0.9 1.7 -0.2 0.9 -0.8 0.1
Age at First Birth 0.7 1.0 2.5 -1.1 0.5 1.2 -0.9 1.1 -0.6 1.6 1.1 -0.7
Bipolar Disorder (2011) 0.9 0.8 1.7 1.3 -0.1 -0.7 1.2 -1.0 1.2 -0.8 -0.3 1.0
Body Mass Index (BMI) (2010) 1.4 2.0 9.2 -0.3 -1.9 -0.3 -1.5 0.4 -3.0 -1.0 -0.2 -1.2
Coronary Artery Disease (CAD) 0.2 0.2 0.5 0.3 -0.2 -0.4 -0.7 0.2 -0.1 -0.7 -0.2 -0.6
Crohns Disease (2012) 0.4 0.6 3.0 0.4 -1.0 -0.3 -0.6 -0.2 0.1 -1.7 0.2 -0.7
Mean Putamen Volume 2.1 2.4 9.8 1.5 -1.9 -1.8 0.8 -1.0 -0.1 -3.1 -1.3 0.2
Fasting Glucose 5.2 6.2 19.0 2.3 0.3 -0.5 3.1 -4.4 1.8 0.6 -0.7 4.1
HbA1C 0.5 0.6 2.0 -0.3 0.8 0.5 0.4 -0.4 1.2 1.4 0.0 0.6
HDL Cholesterol 13.7 22.9 60.0 4.1 2.2 0.4 6.9 -5.7 5.3 3.3 -2.5 7.7
LDL Cholesterol 2.8 4.4 10.7 -1.1 0.1 3.3 -2.5 3.0 -2.3 2.4 0.4 -1.0
Lupus 1.5 2.3 9.3 -0.5 1.9 1.3 1.0 -0.8 1.5 3.0 -0.1 1.4
Neuroticism (2016) 5.5 8.0 14.9 -3.6 3.9 1.0 -1.9 3.0 0.5 3.4 3.2 -2.8
Primary Biliary Cirrhosis 2.9 4.1 9.4 1.7 0.2 -2.8 2.6 -2.6 3.1 -1.4 -0.3 1.1
Rheumatoid Arthritis 1.4 2.0 5.9 -0.6 0.2 2.4 -1.6 1.5 -2.4 -0.0 0.9 -0.1
Schizophrenia (2014) 4.3 9.5 34.5 2.1 -0.3 -5.9 3.2 -3.0 3.1 -4.3 -0.1 0.1
Triglycerides 4.2 6.9 15.8 -2.6 0.0 1.8 -3.2 4.0 -3.5 0.2 2.1 -3.0
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.0 1.2 -1.2 -0.9 1.4 -1.4 -0.3 -1.1 -0.3 1.3
Ulcerative Colitis 0.5 0.7 2.5 -0.3 -0.4 -0.1 -0.4 0.7 -1.6 -0.9 1.3 -0.4
Blood Eosinophil Count 0.2 1.4 6.0 1.1 -0.0 1.3 0.5 -0.3 -2.4 -0.5 -1.5 0.9
Blood Platelet Count 2.6 29.8 121.0 -0.4 5.8 -6.8 6.3 -4.9 11.0 1.3 0.3 1.5
Blood Red Count 0.3 3.0 12.0 0.5 -0.2 1.6 1.0 -0.8 -1.7 1.4 -3.5 2.4
Blood White Count 0.9 6.7 44.8 0.3 -1.8 0.4 -1.7 1.0 -6.7 -2.6 -0.3 -1.0
Heel T-Score 18.5 147.5 295.8 15.5 -8.1 -8.7 13.5 -17.2 8.2 -9.1 -11.6 13.6
BMI 1.6 9.4 29.6 0.5 -3.9 -1.2 -2.8 0.4 -4.9 -5.4 -0.2 -2.5
Height 2.2 42.5 169.0 2.5 3.9 -3.5 8.4 -6.9 13.0 2.3 -3.8 6.5
Waist Hip Ratio (WHR) 0.7 3.2 11.5 -0.3 2.6 0.2 2.2 -1.1 0.8 3.4 0.9 1.8
Systolic Blood Pressure 6.3 31.6 72.2 -8.0 7.4 -3.5 -2.5 5.7 3.2 2.2 5.2 -8.5
Smoking Status 2.4 5.8 17.5 1.2 1.3 -4.2 3.2 -2.8 3.2 -1.4 -0.6 1.1
Allergy or Eczema 0.1 0.2 1.0 -0.5 0.6 0.3 0.2 1.0 -0.5 -0.3 0.3 0.1
Cardiovascular Disease 3.3 11.0 40.2 -3.7 0.8 -3.6 -2.6 3.8 -0.8 -2.7 1.3 -6.3
Hypothyroidism (self reported) 0.6 1.3 4.7 -0.6 -0.0 -2.2 0.4 -1.1 -1.4 -1.4 -0.6 -1.0
Respiratory disease 1.2 2.7 7.1 -2.5 2.7 -0.1 -0.6 1.7 0.4 1.6 1.5 -1.8
Type 2 Diabetes (T2D) (2018) 0.6 1.1 7.1 -0.2 -0.4 -0.0 -0.8 0.7 -2.7 -1.1 -0.2 -0.4
Lung FEV1/FVC ratio 0.4 1.9 7.0 1.4 -1.6 2.6 -0.6 0.3 -1.3 0.4 -1.3 1.4
Lung FVC 1.4 6.9 12.8 3.6 -1.4 -0.6 3.2 -3.3 3.2 -0.5 -1.8 3.5
Neuroticism 7.3 17.5 38.9 -6.2 5.6 0.6 -2.7 4.9 0.5 4.0 3.9 -4.9
Chronotype (morning person) 1.4 3.3 12.2 0.7 -2.5 -2.7 -0.1 -0.3 0.1 -3.5 -1.3 -1.4
Hair Pigment 0.5 13.6 37.8 3.7 1.0 0.4 5.1 -5.2 3.0 1.8 -2.0 6.2
Tanning 0.3 3.8 10.5 1.3 -0.4 -2.6 2.2 -1.1 3.2 -2.4 -1.6 0.8
Hand grip strength (left) 2.1 5.5 24.5 1.2 0.4 -2.7 2.8 -2.0 4.9 -0.0 -1.7 1.2
Number of treatments/medications taken 2.6 4.7 11.2 -2.7 1.0 0.9 -2.8 2.8 -0.7 1.5 1.9 -3.4
Average weekly spirits intake 0.3 0.4 1.5 0.1 -0.6 -0.7 0.1 -0.8 0.6 0.4 -1.2 -0.3
Sensitivity / hurt feelings 3.0 5.1 11.6 -2.4 0.1 2.8 -3.3 3.4 -1.2 1.3 0.9 -2.5
Frequency of depressed mood in last 2 weeks 5.8 8.2 14.1 -3.5 3.8 1.0 -1.8 3.1 -0.1 3.5 3.5 -2.9
Hearing difficulty/problems: Yes 1.0 1.5 5.1 -0.8 2.3 1.6 0.1 -0.0 -0.3 1.9 1.1 0.3
Relative age of first facial hair 0.8 1.6 3.3 1.2 0.4 -0.5 1.8 -1.6 1.8 -0.1 -1.1 1.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 4.8 0.2 0.2 -1.0 0.7 -1.1 2.2 0.8 0.9 -0.4
Ever used hormone-replacement therapy (HRT) 2.4 3.1 6.1 -1.8 0.5 1.5 -2.5 2.0 -2.1 1.2 1.4 -2.1
Ever had hysterectomy (womb removed) 2.6 2.9 6.6 -0.9 0.9 2.6 -1.5 1.5 -2.5 2.3 1.4 -0.3
Systolic blood pressure, automated reading 4.7 13.7 39.1 -5.3 4.3 -2.7 -2.4 3.2 1.6 0.9 3.5 -6.2
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 4.7 1.0 -2.2 -1.1 -0.2 -0.3 -1.4 -1.9 -2.1 -0.2
Angina 2.4 3.2 9.2 -1.4 1.2 1.0 -1.5 2.1 -3.0 0.8 2.1 -1.6
Medication for hormone replacement therapy 1.6 1.8 4.7 0.8 0.7 -1.5 1.4 -2.0 2.2 -0.1 1.0 0.9
Vitamin and mineral supplements 0.2 0.3 0.6 -0.4 0.7 0.1 -0.3 0.8 -0.7 0.2 0.7 -0.6
Supplements: Zinc 1.6 1.7 3.8 1.0 -0.5 -1.8 1.4 -1.6 2.0 -1.4 0.3 0.8
Medication: Co-codamol 1.1 1.3 5.1 -0.5 1.6 -0.5 -0.1 0.4 -0.5 1.6 2.2 -0.8
Medication: Metformin 0.9 1.3 3.0 1.2 -1.4 -1.2 0.3 -0.8 -1.7 -1.6 -0.9 0.1
Diabetes (father) 0.8 1.0 1.8 -0.2 -1.3 1.3 -1.2 0.8 -1.3 -0.3 -1.1 -0.6
Diabetes (mother) 0.5 0.7 2.1 -0.7 0.9 1.4 -0.3 0.4 -0.9 1.0 0.3 0.6
Severe depression (siblings) 2.9 3.3 6.9 2.0 -1.1 -0.1 1.9 -1.8 2.6 -0.8 -2.1 2.3
Pack years adult smoking proportion 1.4 2.2 7.2 -0.1 1.1 -2.7 1.2 -1.3 1.8 -1.3 1.4 -0.9
Impedance of leg (right) 0.9 4.5 15.2 -1.6 3.9 0.5 0.6 2.2 -1.7 2.7 2.6 -0.1
Leg fat-free mass (left) 1.5 7.8 16.5 2.2 -2.7 -2.0 1.8 -3.8 4.1 -2.4 -3.3 1.6
Trunk fat percentage 1.5 6.1 30.5 -0.6 -1.8 -0.8 -2.3 1.0 -5.5 -2.8 0.5 -2.4
Hand grip strength (right) 1.1 3.0 13.6 0.1 1.0 -2.2 2.0 -1.2 3.7 0.6 -1.5 0.3
Townsend deprivation index at recruitment 1.6 2.2 7.7 -1.2 1.7 -1.1 0.3 0.5 2.8 1.4 1.4 -1.5
Current tobacco smoking 2.2 3.6 9.8 -0.9 3.1 -2.8 2.1 -0.9 2.7 0.6 0.8 -0.2
Average weekly fortified wine intake 0.5 0.5 2.1 -0.7 0.7 0.6 -0.5 0.4 -0.8 0.5 1.4 -0.3
Maternal smoking around birth 1.8 2.6 12.1 -0.9 0.8 -3.5 0.6 -0.1 0.9 -1.9 1.3 -1.8
Fed-up feelings 10.8 19.6 41.5 -6.4 5.7 1.3 -3.6 4.9 -1.1 4.2 4.2 -5.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.7 9.1 -2.7 3.0 0.7 -1.4 1.9 1.4 2.9 2.0 -2.4
Relative age voice broke 1.2 1.8 3.3 1.8 -0.7 -0.0 1.5 -1.8 1.2 -0.4 -1.3 1.8
Taking other prescription medications 0.2 0.4 1.4 0.1 0.2 -1.2 0.6 -1.0 -0.1 0.1 0.5 -0.4
Age when periods started (menarche) 0.7 1.7 5.7 0.2 0.4 1.9 0.7 1.0 1.1 2.4 -1.0 1.4
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 6.7 -1.4 1.7 0.3 -1.0 1.4 -0.6 1.0 2.6 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 13.3 30.2 60.2 7.0 -4.0 -3.7 5.8 -7.8 4.3 -4.1 -5.2 6.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.6 0.5 0.3 -0.2 0.5 -0.0 0.5 -0.2 -0.5
Qualifications: CSEs or equivalent 0.3 0.4 2.1 -0.7 0.4 0.2 -0.7 0.4 -0.3 0.1 1.4 -0.6
Serious illness, injury or assault to yourself 0.2 0.2 1.1 0.2 0.2 0.7 0.1 -0.1 -0.4 0.3 1.0 0.1
High blood pressure 6.9 19.3 64.0 -5.4 1.7 -2.0 -4.5 6.2 -2.4 -1.5 2.8 -8.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.2 -0.4 0.5 -0.2 0.1 1.1 -0.5 -0.2 0.7 -0.4
Multivitamins +/- minerals 0.4 0.5 1.3 -1.1 1.2 0.2 0.0 0.4 0.9 1.1 0.3 -0.3
Stomach or abdominal pain in last month 0.7 0.9 1.7 1.3 -0.4 -0.5 1.2 -1.2 1.0 -0.3 -1.2 0.9
Supplements: Glucosamine 1.9 2.5 4.6 2.0 -1.2 -0.0 1.3 -2.1 1.4 -1.1 -1.8 2.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 0.0 1.1 0.9 0.5 -0.7 -0.8 1.4 0.0 1.2
Medication: Atenolol 1.3 1.6 6.1 1.4 -0.8 -2.5 1.1 -0.4 0.8 -1.8 -0.3 -0.6
Medication: Levothyroxine sodium 0.6 1.0 3.3 -0.8 -0.5 -0.6 -1.2 0.3 -1.8 -0.5 -0.2 -1.7
Sitting height 2.9 20.5 84.5 2.2 0.8 -4.2 5.4 -5.3 9.2 -0.9 -2.7 3.3
Chronic bronchitis/emphysema (father) 0.9 1.1 3.5 0.1 0.7 -1.9 1.1 -0.9 1.7 -0.3 0.5 -0.4
High blood pressure (mother) 2.1 3.0 7.1 -2.5 1.0 0.9 -2.3 2.5 -0.1 0.4 0.1 -2.7
Body mass index (BMI) 1.4 5.8 18.0 0.2 -3.2 -0.6 -2.5 0.3 -4.2 -3.4 -0.4 -2.3
Impedance of leg (left) 1.0 4.7 17.0 -1.8 4.1 0.3 0.7 2.1 -1.8 2.5 2.7 -0.1
Leg predicted mass (left) 1.4 7.6 15.6 2.2 -2.8 -1.9 1.7 -3.8 3.9 -2.4 -3.4 1.6
Trunk fat mass 0.7 3.1 9.9 0.2 -2.0 -1.3 -1.1 -0.3 -3.1 -3.0 -0.6 -1.4
Waist circumference 0.6 2.1 10.4 -0.5 -1.2 0.2 -1.7 0.3 -3.2 -1.0 0.3 -1.5
Number of incorrect matches in round 3.3 5.4 11.9 3.2 -2.7 1.0 1.6 -2.2 -1.1 -1.2 -2.8 3.5
Past tobacco smoking 1.1 2.0 8.1 -0.1 -0.5 2.9 -1.1 1.7 -1.9 1.3 -0.4 0.4
Alcohol usually taken with meals 1.9 3.1 10.6 -0.8 0.9 3.2 -0.8 1.0 -2.6 2.4 -0.6 1.2
Nervous feelings 2.2 4.0 14.1 -2.2 1.1 0.7 -1.9 3.8 -0.9 0.7 1.9 -2.6
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.9 6.4 -1.9 2.5 -0.4 -0.4 1.8 0.9 1.6 2.1 -2.0
Hearing difficulty/problems with background noise 7.7 12.3 22.6 -4.8 3.8 2.3 -3.0 4.0 -1.5 3.7 3.6 -3.8
Hair/balding pattern: Pattern 2 1.6 2.1 6.6 1.0 -0.0 -1.7 1.9 -1.8 2.6 -0.3 -0.7 1.0
Had menopause 0.3 0.4 1.7 0.0 1.3 -0.7 0.7 -0.7 0.6 0.4 0.4 0.2
Had other major operations 0.7 0.9 2.6 -0.2 1.2 1.2 0.8 0.1 -0.6 1.6 -0.2 1.2
Forced vital capacity (FVC) 3.4 12.9 36.8 3.1 0.3 -0.7 4.6 -4.3 6.1 1.6 -2.0 4.8
Heel bone mineral density (BMD) T-score, automated (right) 14.9 34.2 64.0 7.7 -4.4 -3.4 6.3 -8.0 4.7 -3.9 -5.6 6.6
Ever unenthusiastic/disinterested for a whole week 2.7 3.3 6.9 1.8 -0.4 -1.8 2.5 -2.3 2.6 -0.6 -1.5 1.5
Qualifications: None of the above 0.5 1.0 2.8 -1.0 1.1 -1.7 0.2 0.9 -0.4 -0.6 0.5 -1.7
Financial difficulties in last 2 years 0.6 0.8 2.7 -0.8 0.8 -0.5 -0.4 0.5 1.3 0.7 0.5 -1.7
Mouth/teeth dental problems 1.8 2.7 12.7 -0.9 1.1 2.4 -1.1 0.3 1.5 3.6 0.5 -0.0
Heart attack 0.4 0.6 2.2 -0.8 1.5 -0.7 0.5 -0.2 0.5 1.0 0.3 -0.5
Allergy 0.1 0.3 0.9 0.8 -1.0 0.1 -0.2 -0.8 0.4 -0.2 -0.5 0.3
Pain all over the body in last month 0.2 0.2 0.6 -0.6 0.6 -0.8 -0.1 -0.4 0.0 -0.0 0.6 -0.7
Diabetes (self-reported) 0.3 0.4 1.9 0.2 -0.7 -0.2 -0.7 0.2 -1.4 -0.7 -0.1 -0.6
Hayfever/allergic rhinitis (self-reported) 4.3 5.7 12.6 -3.5 2.7 0.7 -1.7 2.5 -2.2 1.8 2.9 -2.2
Medication: Ramipril 1.0 1.3 4.3 -0.5 -0.4 -1.4 -0.6 0.8 0.9 -1.8 0.1 -2.1
Medication: Simvastatin 1.2 1.8 5.2 -1.9 0.5 -0.7 -1.4 1.3 -1.3 0.5 0.7 -2.3
Fluid intelligence score 2.3 4.8 13.7 -1.0 3.6 1.1 1.1 0.5 1.7 3.7 2.9 1.2
Illnesses of siblings 1.6 2.3 7.3 0.3 0.5 2.7 0.2 -0.3 0.8 2.6 -0.8 2.2
Neuroticism score 5.4 11.3 23.1 -4.8 4.8 0.5 -2.1 4.0 0.9 3.5 2.8 -3.9
Weight 0.5 2.4 5.4 1.1 -1.9 -1.6 0.5 -2.2 0.7 -2.3 -1.8 0.2
Impedance of arm (right) 0.1 0.6 2.8 -0.1 0.3 -0.8 0.5 0.9 -1.7 -0.3 0.7 -0.1
Arm fat percentage (right) 2.1 8.1 32.4 0.1 -3.2 -0.8 -2.6 0.8 -5.7 -3.9 -0.0 -2.6
Trunk fat-free mass 2.9 16.4 57.3 3.2 -1.4 -1.9 4.1 -5.2 7.6 -1.0 -3.9 3.7
Hip circumference 0.9 4.1 10.4 -1.1 -1.6 0.8 -3.2 1.4 -3.2 -1.5 0.7 -2.6
Time employed in main current job 2.2 2.5 6.9 2.6 -1.4 -0.1 2.0 -1.7 0.8 -0.7 -0.5 2.4
Alcohol intake versus 10 years previously 0.9 1.3 2.9 1.5 -1.7 -0.5 0.4 -0.4 -1.5 -1.4 -1.3 0.7
Father’s age at death 1.5 2.0 5.4 -0.7 -0.3 1.4 -1.7 2.1 -2.3 0.6 1.1 -1.0
Worrier / anxious feelings 0.2 0.4 1.4 -0.7 0.4 -0.4 -0.3 1.2 0.5 -0.2 0.6 -1.0
Frequency of tiredness / lethargy in last 2 weeks 4.2 6.9 12.9 -3.6 3.0 1.1 -2.0 3.2 0.9 3.0 2.5 -2.9
Falls in the last year 1.8 2.4 7.8 -0.9 1.8 -1.9 0.3 -0.2 2.8 0.1 1.9 -1.6
Hair/balding pattern: Pattern 3 2.2 3.3 7.4 -0.8 -1.2 1.3 -2.7 2.4 -2.4 -0.9 1.4 -2.0
Number of live births 1.7 2.4 6.8 1.4 -0.8 -2.6 1.7 -1.8 0.7 -2.1 -1.0 0.4
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 18.1 2.8 -0.5 1.0 3.2 -2.9 4.2 1.9 -2.3 4.3
Pulse rate 0.6 1.0 2.5 0.4 0.5 0.7 0.5 -1.6 1.0 1.2 -0.6 1.5
Happiness 2.0 2.4 5.4 -2.3 1.9 0.2 -1.3 1.5 0.2 1.0 1.8 -2.1
Noisy workplace 1.6 1.9 3.9 0.8 -0.2 -1.9 1.5 -1.6 1.5 -1.3 -2.0 0.3
Qualifications: A levels/AS levels or equivalent 1.9 4.1 16.3 -1.3 0.8 4.0 -1.9 1.5 -1.4 3.2 0.6 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 -0.3 -0.5 1.5 -1.0 1.3 -0.4 0.3 -0.4 -0.3
Mouth/teeth dental problems: Dentures 0.5 0.9 2.6 0.7 1.0 -1.0 1.6 -1.2 -0.2 0.2 -0.4 1.1
Asthma 1.8 3.5 7.1 -2.7 1.8 0.7 -1.6 2.3 -0.6 1.5 1.9 -2.4
Medication: Ibuprofen (e.g. Nurofen) 2.3 3.0 9.4 -0.9 2.0 2.9 -0.4 1.0 -1.0 3.1 0.9 1.1
Medication: Cholesterol lowering 0.5 0.8 2.6 -1.0 0.4 -1.5 -0.3 0.2 0.1 -0.5 0.9 -1.6
Depression (self-reported) 1.2 1.4 4.6 -1.1 1.7 -0.3 0.1 -0.1 2.1 1.4 1.0 -0.8
Medication: Lansoprazole 0.9 1.0 2.5 -0.8 -0.1 0.3 -1.0 1.1 -1.6 0.3 1.6 -1.0
Prospective memory result 2.7 3.3 13.8 0.9 -2.2 -2.7 -0.1 -0.7 1.0 -3.7 -0.2 -1.2
Lung cancer (father) 2.3 2.7 6.1 1.6 0.2 -1.6 2.4 -1.9 2.5 -0.5 -1.3 1.5
Illnesses of mother 0.7 0.9 2.5 1.5 -1.2 0.3 0.7 -1.1 -0.1 0.1 0.5 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 10.5 25.0 3.4 -0.7 0.8 3.7 -3.5 4.7 1.4 -2.6 5.0
Pulse wave Arterial Stiffness index 0.7 0.8 2.3 -1.5 1.5 -0.2 -0.4 0.7 0.0 0.7 0.6 -1.0
Impedance of arm (left) 0.2 0.9 4.3 -0.7 0.8 -0.7 0.1 1.0 -2.1 -0.0 1.1 -0.3
Arm fat mass (right) 1.0 4.2 12.1 0.6 -3.0 -1.2 -1.5 -0.3 -3.1 -3.5 -0.8 -1.6
Trunk predicted mass 2.8 16.0 56.1 3.2 -1.4 -1.9 4.0 -5.2 7.5 -1.1 -3.8 3.7
Standing height 2.9 28.5 110.2 2.5 2.2 -2.8 6.9 -5.8 10.5 1.4 -3.6 5.6
Length of working week for main job 0.8 0.9 3.3 0.9 -0.0 -0.2 0.9 -1.8 1.5 0.1 -0.4 1.1
Exposure to tobacco smoke at home 0.8 0.9 2.5 -0.0 -1.1 -0.2 -1.2 0.8 -1.1 -1.6 0.0 -1.2
Breastfed as a baby 2.6 3.2 11.4 1.0 0.2 -0.3 1.7 -2.3 3.4 0.3 -1.8 2.2
Tense / ‘highly strung’ 0.6 1.1 3.4 -1.1 0.7 -0.6 -0.7 1.8 -0.5 -0.3 0.5 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.8 14.0 -2.3 2.2 -2.2 -0.6 1.3 2.1 0.6 3.7 -2.8
Hair/balding pattern: Pattern 4 2.7 6.5 13.5 -3.7 2.5 0.5 -3.1 2.5 -2.9 1.4 1.8 -3.1
Birth weight of first child 1.4 2.5 8.0 1.2 -0.0 2.4 1.0 -1.1 0.4 1.8 -1.2 2.8
Peak expiratory flow (PEF) 1.1 2.5 9.7 1.0 -0.1 0.7 1.3 -1.2 3.1 1.7 -1.1 2.0
Pulse wave reflection index 0.5 0.7 1.9 -0.9 0.5 -0.3 -0.8 1.0 -1.0 -0.2 0.4 -1.4
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.6 -0.1 1.6 -0.4 1.0 -1.3 1.6 1.3 -0.4 0.5
Loud music exposure frequency 1.1 1.2 3.1 0.6 -1.8 0.5 -0.5 -0.0 -1.6 -1.4 -1.5 -0.0
Qualifications: O levels/GCSEs or equivalent 1.5 2.3 5.2 -1.7 1.1 2.3 -1.4 1.6 -1.5 1.8 1.1 -0.0
Mouth/teeth dental problems: Bleeding gums 4.2 5.4 26.4 1.0 -3.3 -1.8 -0.4 1.1 -2.0 -5.1 -1.0 -1.1
Blood clot in the leg (DVT) 3.4 4.4 11.4 1.4 2.0 -1.6 3.4 -2.9 1.4 0.6 0.5 3.1
Medication: Paracetamol 0.8 1.4 6.0 -0.6 1.4 1.7 -0.1 0.0 -0.6 2.4 0.1 0.7
Headache pain in last month 1.3 2.3 8.6 -0.4 1.6 2.2 -0.0 1.2 -1.2 2.9 0.4 0.8
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 13.4 2.3 -0.8 1.9 1.5 -1.7 -0.1 0.7 -1.8 3.7
Glaucoma (self-reported) 2.5 2.9 6.9 1.2 1.2 1.5 1.8 -1.3 1.5 2.5 -1.0 2.6
Gout (self-reported) 0.4 0.6 1.9 -0.9 0.5 -1.4 -0.2 0.3 0.4 -0.6 -0.3 -1.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 3.6 -1.1 0.0 -1.3 -0.8 0.2 -1.8 -0.7 0.3 -1.9
Medication: Amlodipine 3.7 5.2 18.1 -2.4 0.8 -2.9 -1.6 2.2 0.2 -1.8 1.9 -4.3
Medication: Ventolin 100micrograms inhaler 1.0 1.2 4.3 -1.3 2.1 -0.5 0.1 0.4 0.1 1.1 1.6 -0.9
Birth weight 1.3 2.9 11.5 0.7 0.9 0.2 1.7 -1.5 3.4 1.6 -1.7 1.7
Chronic bronchitis/emphysema (mother) 1.6 1.9 7.0 0.3 1.1 -2.6 1.9 -1.4 1.3 -1.2 -0.3 0.3
High blood pressure (siblings) 1.1 1.6 4.5 -0.8 -0.1 -2.0 -0.3 0.8 -0.7 -1.9 -0.1 -2.1
Forced vital capacity (FVC), Best measure 4.8 17.4 45.7 4.1 -0.3 -0.8 5.3 -4.8 6.8 0.8 -3.1 5.7
Body fat percentage 1.9 7.4 35.8 -0.8 -1.8 -0.9 -2.6 1.3 -6.0 -3.0 0.7 -2.8
Leg fat percentage (right) 2.2 7.9 38.2 -1.0 -1.4 -0.4 -3.0 2.0 -6.2 -2.5 1.2 -3.1
Arm fat-free mass (right) 1.4 7.2 26.6 1.6 -0.3 -1.5 2.7 -3.8 5.2 -0.6 -2.4 2.3
Exposure to tobacco smoke outside home 1.4 1.9 3.1 -1.3 0.1 0.9 -1.7 1.8 -1.5 -0.8 1.7 -1.5
Comparative body size at age 10 1.2 3.2 12.0 0.5 -2.4 -1.6 -1.1 -1.5 -1.6 -3.5 -1.2 -1.1
Number of full brothers 0.9 1.1 3.2 0.0 -0.3 -1.8 0.4 -0.7 1.8 -1.5 -0.6 -0.8
Worry too long after embarrassment 0.3 0.6 1.6 -0.9 0.6 -0.8 -0.2 0.8 1.3 -0.0 0.2 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.5 0.1 0.5 -1.0 0.6 -0.5 1.9 0.3 1.1 -0.4
Wheeze or whistling in the chest in last year 0.8 1.4 5.2 -1.0 1.8 -2.3 1.0 -0.3 -0.2 -0.6 0.4 -1.1
Number of children fathered 2.9 3.3 6.7 2.5 -1.9 -1.3 1.4 -1.7 0.0 -2.6 -1.8 1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 3.8 0.1 -0.5 -2.0 -0.2 -0.4 1.0 -1.2 -0.4 -1.0
Age at first live birth 2.0 3.6 13.4 -1.4 1.5 2.8 -1.4 1.3 -0.9 3.7 1.4 -0.3
Pulse wave peak to peak time 0.8 0.9 2.3 1.5 -1.3 0.0 0.8 -0.9 0.6 -0.6 -0.7 1.3
Health satisfaction 0.7 0.9 2.5 -1.3 1.6 -0.8 -0.1 0.7 1.1 0.5 0.1 -1.2
Shortness of breath walking on level ground 2.7 3.2 7.7 -2.4 2.3 -0.3 -1.2 1.7 -0.7 1.1 2.8 -2.1
Qualifications: College or University degree 0.5 1.6 6.2 -1.0 0.9 1.7 -1.1 0.2 0.1 2.5 1.5 -0.3
Eye problems/disorders: None of the above 0.5 0.6 1.0 -0.9 0.8 1.0 -0.7 1.0 -0.2 0.9 0.7 -0.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.3 -0.6 0.7 -2.3 0.5 -0.3 -0.0 -1.4 1.7 -1.1
Emphysema/chronic bronchitis 0.4 0.5 1.8 -0.4 0.6 -0.8 0.7 -0.2 1.3 -0.7 -0.5 -0.2
Medication for pain relief, constipation, heartburn 0.6 1.1 3.1 0.8 -0.6 -1.5 0.9 -1.1 1.8 -1.1 -0.5 0.4
Neck or shoulder pain in last month 1.4 2.0 7.7 -1.5 2.8 0.5 -0.1 0.6 0.3 2.5 1.0 -0.5
Medication: Blood pressure 3.6 6.3 24.6 -3.0 1.2 -2.0 -2.3 2.8 -0.0 -0.7 2.2 -5.0
Angina (self-reported) 1.9 2.6 8.6 -1.1 1.1 0.9 -1.3 1.8 -2.9 0.8 1.9 -1.3
Migraine (self-reported) 3.0 3.7 12.2 -0.1 2.4 1.6 1.4 -0.8 2.5 3.5 0.1 2.0
Medication: Ibuprofen 1.8 2.1 8.0 -0.5 1.2 2.8 -0.9 1.2 -0.9 2.4 0.5 0.8
Medication: Allopurinol 0.8 1.1 4.0 -1.3 0.4 -0.7 -1.0 0.8 0.6 -0.3 0.9 -2.0
Medication: Omeprazole 0.4 0.5 1.3 1.1 -1.2 0.4 0.1 -0.7 -0.6 0.1 -1.0 0.4
Medication: Seretide 50 evohaler 0.6 0.7 2.2 0.3 0.4 -1.4 0.9 -0.7 1.5 -0.8 -0.4 -0.4
Mean time to correctly identify matches 12.0 22.9 35.6 5.6 -4.4 -5.2 4.7 -5.2 3.6 -6.0 -4.3 3.4
Heart disease (mother) 0.8 1.0 3.3 0.3 -1.1 -1.6 0.6 -0.1 0.1 -1.8 -1.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.4 -1.4 1.9 -0.2 -0.6 1.1 -1.8 0.8 1.8 -1.7
Whole body fat mass 0.8 3.4 10.8 0.1 -2.1 -1.3 -1.3 -0.2 -3.3 -3.0 -0.6 -1.6
Leg fat mass (right) 0.8 3.1 10.8 -0.0 -1.8 -1.1 -1.5 -0.0 -3.3 -2.7 -0.2 -1.8
Arm predicted mass (right) 1.5 7.6 26.2 1.7 -0.4 -1.5 2.8 -4.0 5.1 -0.6 -2.6 2.5
Pulse rate, automated reading 0.5 1.7 4.6 0.8 0.7 1.1 0.5 -2.1 0.9 2.0 -0.0 1.8
Alcohol intake frequency. 1.0 2.4 9.1 1.1 -0.4 2.0 0.4 -1.0 -3.0 0.7 -1.4 1.9
Comparative height size at age 10 3.4 18.5 50.6 2.9 1.2 -2.9 5.8 -5.6 7.1 -0.2 -3.3 4.6
Number of full sisters 0.7 0.9 1.9 0.8 -0.7 -1.2 0.8 -0.7 1.0 -1.2 -1.4 0.4
Suffer from ‘nerves’ 5.5 8.7 17.1 -3.7 4.1 0.8 -1.3 3.2 1.4 3.7 3.6 -2.4
Overall health rating 2.5 5.5 12.4 -3.1 3.5 -1.5 -0.8 1.2 1.0 2.0 2.7 -3.3
Chest pain or discomfort 1.6 2.3 12.5 -1.0 3.5 -1.2 1.4 0.0 1.1 1.2 1.1 -0.2
Had major operations 2.6 3.0 6.9 -2.2 2.0 1.2 -1.2 1.8 -0.1 1.8 2.6 -1.4
Age at last live birth 0.5 0.7 4.1 -0.4 1.0 0.8 0.0 -0.1 0.7 2.0 0.2 0.4
Family relationship satisfaction 0.6 0.8 2.8 -0.7 1.0 -1.2 0.8 -0.5 1.7 -0.4 -0.4 -0.2
Leg pain on walking 1.2 1.5 4.6 -1.1 2.1 -1.0 0.8 0.2 1.1 1.4 1.4 -1.0
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 10.2 3.2 -2.4 0.0 1.3 -1.8 0.2 -1.4 -2.3 2.5
Commuting to job workplace: Car/motor vehicle 2.9 3.3 8.2 2.8 -1.6 0.1 1.9 -2.0 0.3 -1.2 -1.5 2.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 2.4 0.1 -0.5 -0.4 0.1 -0.2 -1.5 -0.4 -0.2 0.3
Medication: Aspirin 0.9 1.1 4.0 -1.1 0.8 -1.5 -0.3 0.4 -0.2 -0.8 1.1 -2.0
Supplements: Vitamin C 1.1 1.3 3.4 1.7 -1.0 0.3 1.3 -1.1 -0.3 -0.8 -0.6 1.8
Knee pain experienced in last month 0.9 1.4 3.2 1.4 0.5 1.0 1.3 -0.8 1.6 0.6 -0.4 1.8
Hypertension (Self-reported) 6.6 18.3 62.7 -5.0 1.5 -2.5 -4.2 5.7 -2.3 -2.2 2.8 -7.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.4 0.7 0.0 0.8 1.0 -0.1 0.8 0.5 -1.4 1.5
Illnesses of father: Heart disease 0.9 1.3 3.6 -1.7 0.8 -0.3 -1.2 1.1 0.5 0.3 1.1 -1.9
Illnesses of siblings: Diabetes 0.7 0.9 2.2 0.3 -1.4 0.2 -0.8 0.2 -1.5 -1.5 -0.3 -0.5
Smoking status: Previous 0.7 1.1 2.8 1.0 -1.1 -1.4 0.4 -1.4 0.8 -1.7 -0.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted 3.5 7.2 20.7 2.3 -0.6 -0.3 3.1 -3.2 4.5 0.6 -2.6 3.5
Whole body fat-free mass 2.1 12.1 38.2 2.8 -1.9 -1.9 3.1 -4.7 6.2 -1.6 -3.7 2.9
Leg fat-free mass (right) 1.5 8.2 18.7 2.2 -2.7 -1.9 1.8 -4.0 4.3 -2.3 -3.4 1.8
Arm fat percentage (left) 2.3 9.0 37.0 -0.3 -3.1 -0.7 -3.1 1.1 -6.1 -3.8 0.2 -2.9
Average weekly red wine intake 0.1 0.2 0.6 0.1 -0.6 0.5 -0.7 0.1 0.6 0.3 -0.5 0.0
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 -0.0 -0.5 -0.5 -0.5 0.7 0.9 -0.8 0.8 -0.5
Mood swings 4.4 7.9 16.7 -3.8 3.2 -0.2 -2.1 4.1 0.0 1.7 2.6 -4.0
Loneliness, isolation 5.1 7.0 16.9 -3.6 4.1 -0.2 -0.7 2.5 2.1 3.1 2.6 -2.4
Long-standing illness, disability or infirmity 1.0 1.5 4.8 0.1 1.0 -2.2 1.3 -1.2 1.8 -0.3 1.0 -0.5
Ever had bowel cancer screening 0.6 0.8 1.7 1.1 -1.1 0.4 0.3 -0.8 -1.2 -0.7 -0.1 1.3
Diabetes diagnosed by doctor 0.2 0.3 1.2 0.6 -0.5 -0.4 0.0 -0.6 -1.1 -0.5 -0.5 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.9 0.6 -0.7 0.1 0.7 -0.3 -0.4 -0.0 -1.7 1.0
Friendships satisfaction 1.5 1.9 5.9 -1.3 2.4 -1.2 0.8 -0.6 1.8 1.4 1.3 -0.6
Qualifications: nursing, teaching 0.8 1.2 3.8 -1.6 -0.1 0.0 -1.8 1.1 0.0 0.3 0.4 -1.9
Commuting to job workplace: Walk 2.6 2.8 5.8 -2.4 2.3 0.4 -0.9 1.6 0.1 2.0 2.0 -1.6
Eye problems/disorders: Cataract 0.3 0.4 1.4 -0.1 0.0 -1.2 0.1 -1.0 -0.3 -0.6 0.3 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.4 0.9 -1.4 -0.9 0.5 -0.7 0.8 -2.1 -0.2 0.0
Medication for cholesterol 1.4 2.2 7.6 1.3 0.3 1.5 1.4 -1.5 0.5 1.7 -0.7 2.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 9.8 1.8 -3.1 -1.1 0.2 -0.9 -0.1 -3.1 -1.2 0.2
Back pain experienced in last month 3.0 4.4 12.8 -2.0 2.8 2.2 -1.2 2.2 -0.5 3.6 1.6 -1.1
Mineral and other dietary supplements 0.2 0.3 0.7 0.0 0.9 -0.9 0.6 -0.4 0.6 0.3 0.2 0.1
Breast cancer (self-reported) 0.3 0.4 1.2 0.9 -1.1 -0.3 0.4 -0.4 -0.2 -0.6 -0.9 0.2
Asthma (self-reported) 1.5 3.1 6.5 -2.5 1.9 0.5 -1.4 2.1 -0.4 1.4 1.9 -2.3
Osteoporosis (self-reported) 4.2 5.2 9.5 -2.7 2.0 1.9 -1.9 2.4 -1.2 3.1 2.8 -1.7
Osteoarthritis (self-reported) 0.6 0.8 2.1 -0.9 1.0 0.6 -0.4 0.5 1.4 1.4 0.3 -0.7
Medication: Aspirin 0.6 0.8 2.7 -0.5 0.1 -1.6 -0.1 0.1 0.2 -1.2 0.4 -1.6
Medication: Gliclazide 0.8 0.9 2.7 0.7 -0.6 -1.6 0.4 -1.0 -0.6 -1.7 0.4 -0.1
Illnesses of father: None of the above (group 1) 1.9 2.4 8.6 2.0 -0.8 0.6 1.6 -1.8 -0.2 -0.6 -1.3 2.9
Smoking status: Current 2.2 3.5 10.3 -0.9 3.2 -2.8 2.1 -0.9 2.5 0.4 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 8.3 2.9 -2.1 0.7 1.4 -1.1 -0.2 -1.2 -1.5 2.5
Whole body water mass 2.1 12.0 38.3 2.7 -1.8 -1.8 3.2 -4.7 6.2 -1.4 -3.7 2.9
Leg predicted mass (right) 1.6 8.4 18.4 2.3 -2.8 -1.9 1.9 -4.0 4.3 -2.4 -3.5 1.8
Arm fat mass (left) 0.9 3.9 11.1 0.6 -2.8 -1.1 -1.4 -0.5 -3.1 -3.3 -0.8 -1.4
Number of self-reported non-cancer illnesses 4.4 7.6 16.1 -4.0 3.7 -0.5 -1.4 2.6 0.5 2.6 3.1 -3.6
Average weekly champagne plus white wine intake 0.4 0.6 1.9 0.8 0.5 0.1 1.2 -0.2 -0.4 -0.7 0.2 1.4
Miserableness 8.7 15.1 31.2 -5.6 4.4 0.8 -3.2 5.5 -1.1 3.0 3.0 -5.0
Guilty feelings 3.3 4.9 11.1 -2.5 3.3 -2.2 -0.3 1.5 2.3 0.6 2.2 -3.0
Wears glasses or contact lenses 0.4 0.4 1.3 0.5 -0.4 -0.8 -0.0 -0.4 0.8 -0.9 -1.1 -0.4
Ever taken oral contraceptive pill 2.0 2.2 7.8 -0.4 0.8 2.8 -0.6 0.5 1.5 2.8 0.1 0.9
Hearing aid user 0.9 1.0 2.9 0.2 -0.7 -0.6 -0.7 0.3 -1.7 -1.7 0.6 -1.0
Mother’s age at death 0.9 1.1 4.0 -0.1 -0.3 2.0 -1.2 1.4 -1.1 0.8 0.5 -0.2
Financial situation satisfaction 0.3 0.4 1.5 -0.6 0.7 0.0 0.3 -0.3 1.2 0.9 0.1 -0.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 0.2 0.1 -0.8 0.6 0.1 -0.6 -0.4 -1.1 0.1
Commuting to job workplace: Public transport 0.7 0.8 1.9 -1.3 0.5 -0.1 -0.9 0.9 0.6 1.0 0.8 -1.4
Eye problems/disorders: Glaucoma 3.1 3.7 8.5 1.0 1.8 0.8 2.3 -1.8 1.9 2.7 -0.4 2.9
Medication: Blood pressure 3.1 6.0 16.5 -2.3 -0.3 -1.3 -2.4 3.6 -2.1 -2.6 0.7 -4.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.9 -1.0 1.4 -0.2 -0.4 0.4 0.8 1.7 0.0 -0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.2 5.0 1.3 -2.2 0.5 -0.5 -0.4 -0.0 -1.6 -1.1 0.4
High cholesterol (Self-reported) 1.2 2.1 6.6 -2.1 0.8 -1.8 -0.9 1.3 -0.8 -0.5 1.1 -2.6
Medication: Bendroflumethiazide 2.9 4.4 13.1 -2.7 0.9 -1.2 -2.0 3.3 -1.1 -0.9 0.5 -3.6
Medication: Paracetamol 0.6 0.9 3.6 -0.2 1.1 1.4 0.1 -0.5 -0.3 1.9 0.1 1.1
Medication: Lisinopril 3.6 4.6 10.8 -2.7 1.5 -0.6 -1.9 3.0 -1.8 0.0 2.3 -3.3
Medication: Atorvastatin 0.5 0.6 1.5 0.4 -1.1 -1.2 -0.2 -0.4 0.4 -1.1 -0.3 -1.0
Illnesses of father: High blood pressure 1.1 1.3 4.8 -0.6 0.4 -2.2 0.5 0.8 0.9 -1.4 0.2 -1.6
Alcohol drinker status: Never 1.0 1.3 9.1 -0.1 0.3 0.8 -0.7 0.5 -3.0 -0.0 0.8 0.2
Ever smoked 0.9 1.6 5.9 -0.5 1.2 -2.4 1.2 -1.3 1.9 -0.6 0.4 -0.2
Basal metabolic rate 1.6 8.8 23.3 2.4 -2.0 -1.8 2.5 -4.1 4.8 -1.9 -3.3 2.3
Leg fat percentage (left) 2.2 7.9 37.8 -0.8 -1.6 -0.6 -2.8 1.6 -6.2 -2.9 1.1 -3.1
Arm fat-free mass (left) 1.4 6.9 24.7 1.9 -0.9 -1.4 2.5 -3.6 5.0 -0.8 -2.6 2.1
Number of operations (self-reported) 0.5 0.8 1.8 0.0 0.5 1.3 0.5 -0.1 -0.9 0.9 1.3 1.1
Average weekly beer plus cider intake 3.0 4.3 10.9 1.6 0.2 -3.2 2.5 -2.2 3.3 -1.7 0.1 0.8
Irritability 0.5 0.9 2.3 -1.0 1.5 0.6 -0.4 1.0 0.2 1.5 0.8 -0.7
Risk taking 1.9 2.8 10.7 1.5 -0.8 -1.6 1.6 -2.1 3.3 -0.7 -0.8 0.9
Ever had prostate specific antigen (PSA) test 1.5 1.7 3.6 -1.8 1.2 0.5 -1.5 1.3 -0.3 0.8 1.9 -1.5
Fractured/broken bones in last 5 years 1.7 2.2 5.9 -1.6 1.1 0.8 -0.9 2.0 0.9 1.2 2.4 -1.5
Age started oral contraceptive pill 0.6 0.7 1.8 -1.1 0.0 0.9 -0.8 1.3 -1.4 0.2 -0.1 -0.4
Diastolic blood pressure, automated reading 2.1 6.7 22.6 -3.5 2.7 -2.4 -1.5 2.4 0.1 -0.2 2.0 -4.8
Ever depressed for a whole week 0.7 0.8 3.6 0.6 -0.5 -1.2 0.8 -0.9 1.9 -0.3 -0.1 0.3
Unable to work because of sickness or disability 1.5 2.0 10.2 -0.3 1.2 -1.9 0.8 -0.9 3.2 -0.3 0.4 -0.8
Commuting to job workplace: Cycle 0.5 0.6 1.7 -0.0 -1.3 0.1 -1.2 0.5 -0.5 -0.3 -1.0 -0.8
Myopia 2.2 3.3 9.3 1.0 1.4 -2.0 2.4 -1.9 3.0 -0.5 0.6 1.7
Vascular/heart problems diagnosed by doctor 6.3 17.2 57.2 5.2 -2.0 2.2 4.0 -5.6 2.2 1.4 -2.9 7.6
Cholesterol lowering medication 1.6 2.4 7.3 -1.8 0.1 0.0 -1.7 2.0 -2.7 0.2 -0.1 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.5 1.1 -0.9 0.7 0.0 -0.5 -1.2 0.1 -0.2 0.5
Pain experienced in last month 2.4 4.0 8.6 1.9 -2.4 -2.4 1.3 -2.3 1.6 -2.9 -1.5 0.7
Supplements: Calcium 1.0 1.1 3.9 -1.1 1.1 0.6 -0.2 0.4 0.9 1.6 2.0 -0.3
Basal cell carcinoma (self-reported) 1.2 1.5 4.7 -1.2 -0.5 -1.0 -1.2 1.2 -0.2 -1.3 1.0 -2.2
Heart attack/myocardial infarction (self-reported) 0.7 1.0 3.4 -0.8 1.8 -1.1 0.9 -0.5 0.9 1.0 0.5 -0.5
Deep venous thrombosis (DVT) (self-reported) 3.6 4.6 12.5 1.7 1.5 -1.8 3.5 -3.0 1.5 0.1 0.2 3.1
Heart disease (siblings) 1.0 1.3 2.4 1.3 -0.6 -1.5 1.5 -1.4 0.6 -1.2 -0.4 0.8
Alcohol drinker status: Previous 1.1 1.3 3.2 -1.5 1.2 -1.1 -0.4 0.4 -0.3 0.6 1.8 -1.6
Pack years of smoking 1.8 2.6 9.0 -0.1 1.2 -3.0 1.3 -1.5 1.9 -1.5 1.5 -0.9
Impedance of whole body 0.6 3.2 7.8 -1.7 2.8 0.1 0.1 2.1 -2.6 1.7 2.0 -0.4
Leg fat mass (left) 0.8 3.2 9.5 0.3 -2.0 -1.5 -1.2 -0.5 -3.1 -3.1 -0.3 -1.5
Arm predicted mass (left) 1.2 6.2 21.9 1.7 -0.8 -1.3 2.4 -3.5 4.7 -0.7 -2.5 2.1