Hub : Genes

C11orf49

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.4030 0.0820 3.6e-15 0.194 0.152 0.182 0.195 0.194 4.2e-23 5.0e-18 1.2e-21 2.9e-23 4.1e-23
2 GTEx Esophagus Mucosa 0.1890 0.0650 2.7e-06 0.054 NA 0.117 NA 0.098 1.6e-04 NA 3.2e-08 NA 4.6e-07
3 GTEx Nerve Tibial 0.1663 0.0624 2.8e-05 0.013 NA 0.055 NA 0.021 3.9e-02 NA 9.5e-05 NA 1.2e-02
4 GTEx Skin Not Sun Exposed Suprapubic 0.0860 0.0370 1.4e-03 0.004 NA 0.033 NA 0.031 1.8e-01 NA 6.0e-03 NA 8.3e-03
5 GTEx Testis 0.5710 0.0730 1.1e-15 0.448 NA 0.464 NA 0.460 8.0e-22 NA 8.1e-23 NA 1.3e-22
6 GTEx Thyroid 0.0900 0.0420 3.5e-04 0.048 NA 0.042 NA 0.043 1.5e-04 NA 3.5e-04 NA 3.0e-04
7 GTEx Uterus 0.2390 0.1080 9.4e-03 0.237 NA 0.200 NA 0.237 1.3e-05 NA 7.0e-05 NA 1.3e-05
8 ROSMAP Brain Pre-frontal Cortex 0.0227 0.0108 3.1e-04 0.022 0.025 0.017 0.023 0.022 7.2e-04 3.3e-04 2.8e-03 4.8e-04 7.0e-04
9 TCGA Breast Invasive Carcinoma 0.0528 0.0270 1.6e-04 0.003 0.015 0.015 NA 0.006 7.0e-02 3.0e-04 3.3e-04 NA 2.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.5 0.8 2.1 0.5 -0.0 1.1 0.6 -1.2 -0.6 -0.6 1.5 0.9
Bipolar Disorder or Schizophrenia 2.6 6.4 16.8 1.0 -4.1 -0.1 -1.3 -3.1 -3.6 -3.5 1.8 -0.7
Depressed Affect (Nagel 2018) 5.8 12.1 30.7 4.1 -0.5 -1.2 3.4 -1.1 4.1 4.1 -5.5 -3.6
Depression (Nagel 2018) 3.4 5.1 11.9 1.6 0.5 0.7 3.4 0.2 3.4 3.4 -2.6 -0.7
Intelligence (Savage-Jansen 2018) 3.3 10.1 20.0 2.9 4.1 3.6 3.6 -1.0 4.5 4.4 0.1 0.6
Neuroticism (Nagel 2018) 3.6 8.5 24.7 2.9 0.1 -1.6 2.2 -0.4 3.6 3.6 -5.0 -3.2
Schizophrenia (2018) 4.2 8.7 26.4 0.9 -5.1 -0.9 -2.0 -3.0 -4.2 -4.1 1.1 -1.6
Schizophrenia vs Biploar Disorder 5.2 6.9 14.3 1.2 -3.7 -0.3 -2.2 -2.8 -3.8 -3.7 1.6 -1.8
Worry (Nagel 2018) 1.3 2.7 6.2 2.1 0.7 -0.4 1.0 -0.9 1.9 1.9 -2.5 -1.9
Alzheimer’s Disease (in mother) 1.1 1.3 2.7 0.3 -0.8 -0.6 -1.6 -1.6 -1.5 -1.5 0.3 -0.8
Alzheimer’s Disease (in father) 1.1 1.2 2.4 -0.3 1.3 1.5 0.8 -1.0 1.4 1.4 0.5 0.6
Alzheimer’s Disease (including proxy) 0.4 0.7 4.0 0.9 0.3 0.1 -0.8 -2.0 -0.1 -0.2 0.3 -0.4
Crohns Disease (2017) 0.7 1.6 4.2 -1.6 -1.3 -2.1 -0.5 1.9 -0.8 -0.8 -0.8 -0.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.6 -0.6 -0.7 -1.3 0.1 1.3 -0.5 -0.5 -0.5 -0.1
Ulcerative Colitis (UC) 0.2 0.3 0.8 0.3 -0.7 -0.7 -0.3 0.3 -0.9 -0.9 -0.1 -0.6
Major Depression (MDD) 1.7 2.1 4.7 2.2 -1.9 -1.7 -0.0 -0.7 -0.6 -0.6 -1.3 -2.1
Reaction Time 6.7 12.8 29.5 -0.7 -3.1 1.6 -3.6 -2.8 -5.4 -5.4 4.8 0.9
Verbal and Numeric Reasoning (VNR) 4.3 10.4 20.7 2.6 3.6 3.6 4.4 -0.7 4.6 4.5 -0.2 0.3
Breast Cancer 0.3 0.6 1.6 0.7 0.4 -0.6 -0.2 -1.2 0.2 0.3 -1.2 -1.0
Ovarian Cancer 1.7 2.2 7.1 0.1 2.7 1.5 1.1 0.9 1.6 1.5 1.0 1.7
Prostate Cancer 0.4 0.6 1.7 1.0 1.3 0.1 -0.0 0.5 0.9 0.9 -0.7 -0.6
Age at First Birth 0.9 1.3 3.2 -0.5 1.2 -0.3 1.8 0.8 1.6 1.5 -1.1 0.4
Bipolar Disorder (2011) 0.6 0.6 1.6 -0.3 0.2 0.3 0.2 -0.8 -0.9 -0.9 1.3 1.2
Body Mass Index (BMI) (2010) 1.9 2.6 6.7 -2.6 -1.7 -1.6 -2.2 1.2 -0.9 -1.0 -1.4 -1.4
Coronary Artery Disease (CAD) 0.5 0.6 1.4 -1.2 -0.7 -1.1 -0.4 0.5 -0.7 -0.7 -0.1 0.6
Crohns Disease (2012) 1.2 1.9 3.6 -1.2 -1.9 -1.8 -1.3 1.1 -1.7 -1.7 -0.3 -0.6
Mean Putamen Volume 3.5 4.0 9.7 -0.9 -2.4 -1.1 -2.5 -0.9 -3.1 -3.1 0.8 -1.0
Fasting Glucose 3.7 4.4 12.9 -0.2 2.1 3.3 1.6 -1.1 0.6 0.6 3.6 2.6
HbA1C 0.9 1.0 2.9 0.7 1.7 0.8 1.1 -0.2 1.3 1.2 0.3 0.8
HDL Cholesterol 18.2 30.3 70.7 2.0 7.3 8.4 4.6 -4.1 2.9 2.7 6.9 6.6
LDL Cholesterol 2.2 3.4 7.3 0.3 2.4 0.0 1.3 2.5 2.6 2.7 -1.8 0.3
Lupus 3.7 5.6 10.6 0.5 3.3 2.5 2.9 -0.0 3.2 3.2 0.8 2.0
Neuroticism (2016) 3.3 4.7 11.7 1.7 0.9 -0.3 2.5 0.3 3.4 3.2 -2.9 -1.3
Primary Biliary Cirrhosis 1.3 1.9 4.6 1.0 -0.8 1.7 0.1 -2.1 -1.4 -1.3 2.0 0.4
Rheumatoid Arthritis 1.1 1.5 3.2 0.7 0.2 -1.7 -1.7 1.3 -0.1 -0.1 -1.4 -1.8
Schizophrenia (2014) 4.4 9.8 22.6 1.7 -4.8 0.3 -1.7 -4.2 -4.2 -4.2 2.1 -1.4
Triglycerides 3.0 4.9 15.4 0.9 -0.9 -3.1 -1.4 1.8 0.5 0.8 -3.9 -3.4
Type 2 Diabetes (T2D) (2012) 0.8 1.0 2.0 -0.7 -0.1 0.1 -1.4 -1.4 -1.1 -1.1 1.0 -0.7
Ulcerative Colitis 0.6 0.9 1.8 0.4 -0.7 -1.3 -1.2 0.5 -0.9 -0.8 -0.7 -1.3
Blood Eosinophil Count 0.2 1.4 4.1 -2.0 0.8 0.0 -1.9 -1.6 -0.7 -0.7 0.6 0.5
Blood Platelet Count 1.7 19.6 47.2 6.2 0.9 4.7 6.9 -6.4 1.4 1.4 3.7 3.2
Blood Red Count 0.3 2.6 8.6 -0.7 2.9 2.3 0.6 -0.1 1.4 1.4 1.0 2.0
Blood White Count 0.9 7.0 14.8 -2.1 -2.4 -3.7 -3.9 0.4 -2.7 -2.8 -1.7 -2.5
Heel T-Score 10.2 81.1 285.6 -5.3 1.5 8.1 -2.1 -7.5 -9.0 -8.8 16.9 11.4
BMI 4.0 23.2 43.7 -5.6 -6.6 -5.0 -5.7 2.1 -5.3 -5.2 -2.0 -3.5
Height 1.7 32.9 69.2 3.7 5.2 8.3 6.7 -5.4 2.4 2.4 7.3 6.8
Waist Hip Ratio (WHR) 1.7 7.8 14.0 1.6 3.7 3.6 3.2 -1.8 3.5 3.5 0.7 1.5
Systolic Blood Pressure 3.1 15.5 47.3 3.5 -3.4 -4.5 2.6 -3.0 2.3 2.3 -6.9 -4.7
Smoking Status 1.8 4.2 13.5 2.3 -1.3 2.2 0.9 -3.7 -1.4 -1.4 2.6 1.0
Allergy or Eczema 0.4 1.0 3.5 0.6 0.2 -0.3 -1.5 -1.6 -0.2 -0.2 -0.5 -1.9
Cardiovascular Disease 4.7 15.7 37.6 0.0 -6.1 -5.3 -3.0 -1.4 -2.8 -2.8 -4.7 -5.2
Hypothyroidism (self reported) 0.7 1.6 6.2 -1.1 -2.5 -0.6 -0.5 -1.3 -1.4 -1.4 -0.4 -0.8
Respiratory disease 0.6 1.3 3.3 0.3 -0.0 0.2 1.6 -0.7 1.6 1.5 -1.8 -0.8
Type 2 Diabetes (T2D) (2018) 1.0 2.0 5.0 -0.6 -1.9 -0.9 -2.2 0.0 -1.2 -1.3 -0.8 -2.1
Lung FEV1/FVC ratio 0.3 1.3 5.2 -0.1 2.3 -0.3 -1.3 1.9 0.4 0.4 0.4 0.8
Lung FVC 0.9 4.7 15.4 -0.7 2.5 2.3 0.5 -1.1 -0.6 -0.6 3.9 3.6
Neuroticism 4.2 10.1 24.7 3.6 -0.1 -0.9 3.3 -0.4 4.1 4.1 -5.0 -2.9
Chronotype (morning person) 3.0 7.0 14.2 -1.1 -3.8 -2.9 -2.8 -0.8 -3.6 -3.6 -0.6 -2.4
Hair Pigment 0.6 18.2 44.9 0.3 5.4 6.7 3.4 -2.9 1.9 1.9 5.9 5.3
Tanning 0.3 3.8 9.1 3.0 -1.3 -0.7 -1.3 -2.5 -2.4 -2.5 1.4 -0.8
Hand grip strength (left) 1.2 3.2 6.2 1.5 0.9 2.2 1.8 -2.3 -0.2 -0.3 2.5 2.4
Number of treatments/medications taken 1.6 2.8 8.9 -1.7 -0.7 -1.7 0.5 2.3 1.5 1.5 -3.0 -0.4
Average weekly spirits intake 1.1 1.3 4.0 -1.9 0.2 1.0 1.4 0.6 0.4 0.4 0.5 2.0
Sensitivity / hurt feelings 1.9 3.2 9.2 -0.6 -0.4 -2.0 -0.8 3.0 1.2 1.1 -3.0 -1.7
Frequency of depressed mood in last 2 weeks 3.8 5.4 12.3 2.3 0.7 0.6 2.7 0.3 3.5 3.5 -3.0 -1.4
Hearing difficulty/problems: Yes 1.1 1.7 4.1 1.3 1.5 0.8 1.4 -0.2 2.0 2.0 -0.5 -0.2
Relative age of first facial hair 0.6 1.3 3.2 0.3 0.8 1.4 0.9 -1.5 -0.1 -0.1 1.8 1.6
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.2 -1.5 0.1 1.1 1.8 0.4 0.8 0.8 0.5 1.6
Ever used hormone-replacement therapy (HRT) 1.8 2.3 5.4 -2.0 -0.4 -1.1 0.9 2.3 1.3 1.4 -2.2 -0.5
Ever had hysterectomy (womb removed) 2.1 2.4 5.8 -1.0 2.2 -0.2 0.8 1.2 2.4 2.4 -1.5 0.3
Systolic blood pressure, automated reading 2.1 6.2 20.5 0.6 -3.5 -3.0 2.4 -0.8 1.0 1.1 -4.5 -2.3
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 4.3 -1.7 -1.7 -0.9 -2.1 0.1 -2.0 -2.0 0.0 -0.6
Angina 0.7 0.9 4.0 0.3 -0.3 -0.7 -0.4 0.4 0.7 0.7 -2.0 -1.6
Medication for hormone replacement therapy 1.1 1.2 2.9 -0.7 -0.3 1.7 1.5 -0.8 -0.1 -0.2 1.6 1.3
Vitamin and mineral supplements 0.2 0.3 0.8 0.3 -0.2 -0.4 -0.1 -0.9 0.3 0.4 -0.7 -0.9
Supplements: Zinc 1.0 1.1 2.2 1.2 -1.1 0.1 -0.9 -0.8 -1.5 -1.5 1.3 -0.3
Medication: Co-codamol 1.5 1.7 3.3 -1.7 0.7 1.2 1.8 -0.2 1.7 1.8 -0.4 0.8
Medication: Metformin 1.4 2.0 4.4 -1.5 -2.0 -0.2 -2.1 -0.2 -1.7 -1.7 0.3 -0.9
Diabetes (father) 1.0 1.2 3.6 -1.7 -0.1 -1.9 -1.0 1.4 -0.3 -0.3 -1.1 -0.6
Diabetes (mother) 0.4 0.5 1.0 1.0 0.8 0.7 0.4 0.1 1.0 0.9 -0.3 -0.7
Severe depression (siblings) 1.1 1.2 5.2 0.3 1.3 0.8 -0.3 -0.8 -0.7 -0.6 2.3 1.4
Pack years adult smoking proportion 1.1 1.7 6.9 0.4 -2.6 -0.3 0.1 -2.0 -1.4 -1.4 0.3 -0.5
Impedance of leg (right) 1.4 6.7 23.0 4.8 2.4 1.5 0.6 -2.9 2.6 2.6 -1.3 -2.2
Leg fat-free mass (left) 0.9 4.6 9.6 -3.1 -1.5 0.7 0.1 0.7 -2.4 -2.4 3.0 2.8
Trunk fat percentage 2.5 10.1 21.9 -3.1 -4.7 -2.9 -3.8 1.0 -2.7 -2.6 -2.6 -3.8
Hand grip strength (right) 0.9 2.3 5.1 1.0 0.6 2.0 2.2 -2.2 0.5 0.4 1.5 1.8
Townsend deprivation index at recruitment 0.9 1.2 3.5 0.1 -0.4 1.3 1.9 -0.6 1.5 1.5 -0.4 0.7
Current tobacco smoking 1.9 3.2 11.5 3.4 -0.5 1.8 1.6 -3.2 0.5 0.5 0.6 -0.1
Average weekly fortified wine intake 0.4 0.5 1.7 1.3 0.3 -0.2 0.5 0.6 0.7 0.8 -0.7 -0.8
Maternal smoking around birth 2.6 3.7 10.3 1.1 -3.2 -1.7 -0.8 -2.1 -2.0 -2.0 -1.0 -2.3
Fed-up feelings 5.7 10.4 28.9 2.6 -0.4 -1.3 3.2 0.2 4.3 4.3 -5.4 -2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 3.9 10.8 0.6 0.7 0.9 3.3 0.9 3.0 3.1 -1.9 0.5
Relative age voice broke 0.7 1.1 3.9 -0.0 0.9 0.9 0.0 -0.8 -0.4 -0.4 2.0 1.7
Taking other prescription medications 0.2 0.3 1.7 -1.3 -0.6 0.3 0.4 -0.4 0.1 0.1 0.0 0.3
Age when periods started (menarche) 1.7 4.1 12.3 2.2 3.5 2.1 1.1 -0.3 2.4 2.3 0.7 1.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.4 0.1 -0.7 -0.7 0.8 -0.0 0.9 0.8 -1.6 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 8.0 18.2 59.9 -4.0 1.1 3.8 -1.0 -2.7 -4.0 -3.9 7.7 5.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.1 0.1 -0.4 -0.4 -0.3 0.5 0.5 -0.6 -0.4
Qualifications: CSEs or equivalent 0.2 0.3 1.2 0.0 -0.4 -0.7 -0.2 0.3 0.0 0.0 -0.7 -1.1
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.3 0.1 -0.2 -0.0 -0.1 0.3 0.2 -0.1 -0.1
High blood pressure 6.4 17.7 44.6 0.1 -5.7 -6.3 -2.3 0.1 -1.5 -1.5 -6.7 -5.7
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.8 0.9 -0.1 -0.0 -1.3 -1.5 -0.2 -0.2 -0.5 -1.7
Multivitamins +/- minerals 0.4 0.5 1.1 0.9 0.6 0.5 0.9 0.2 1.1 1.0 -0.5 0.4
Stomach or abdominal pain in last month 0.4 0.5 1.7 -0.2 0.7 1.0 0.4 -0.5 -0.3 -0.3 1.3 0.8
Supplements: Glucosamine 1.6 2.1 6.5 -1.8 0.9 0.7 0.2 0.5 -1.1 -1.1 2.2 2.5
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 3.6 -0.4 1.9 1.2 1.5 -0.5 1.4 1.4 0.5 1.2
Medication: Atenolol 1.1 1.4 3.2 0.0 -1.3 -0.4 -1.0 -1.5 -1.8 -1.8 0.6 0.6
Medication: Levothyroxine sodium 0.6 1.1 3.4 -1.4 -1.8 -1.4 -0.3 0.7 -0.5 -0.5 -1.2 -0.2
Sitting height 1.3 9.0 24.6 2.1 1.4 3.1 3.0 -3.9 -0.9 -0.9 5.0 3.8
Chronic bronchitis/emphysema (father) 0.6 0.7 1.5 -0.4 -0.9 1.2 1.2 -1.2 -0.3 -0.3 0.5 0.4
High blood pressure (mother) 1.1 1.6 5.8 -1.2 -0.8 -2.1 0.2 0.9 0.3 0.3 -2.4 -0.8
Body mass index (BMI) 2.7 11.7 26.9 -5.2 -4.7 -3.1 -3.5 2.3 -3.4 -3.2 -1.7 -2.0
Impedance of leg (left) 1.5 7.2 25.4 5.0 2.2 1.2 0.4 -3.3 2.5 2.5 -1.4 -2.7
Leg predicted mass (left) 0.9 4.6 10.0 -3.2 -1.5 0.7 0.0 0.7 -2.4 -2.4 2.9 2.8
Trunk fat mass 1.7 7.3 17.1 -3.3 -4.1 -2.0 -3.1 0.6 -2.9 -2.9 -1.1 -2.3
Waist circumference 0.8 3.0 10.2 -3.2 -2.4 -1.1 -1.4 1.7 -0.9 -0.9 -1.5 -1.1
Number of incorrect matches in round 1.4 2.3 6.7 -1.5 2.0 0.3 -1.6 -0.1 -1.2 -1.2 2.6 1.6
Past tobacco smoking 0.7 1.4 4.8 -0.8 2.2 -0.3 -0.4 1.4 1.3 1.3 -1.0 -0.1
Alcohol usually taken with meals 1.7 2.8 11.1 1.0 3.3 0.5 0.7 0.5 2.4 2.4 -0.6 0.3
Nervous feelings 1.1 2.1 7.7 1.4 -0.2 -1.4 -1.1 0.4 0.7 0.7 -2.8 -2.3
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 6.0 2.5 -0.2 0.3 1.4 -0.6 1.7 1.8 -1.7 -1.3
Hearing difficulty/problems with background noise 4.6 7.4 19.4 2.2 0.4 -1.2 2.3 1.4 3.8 3.8 -4.4 -2.3
Hair/balding pattern: Pattern 2 1.0 1.2 3.0 0.9 0.4 1.4 0.5 -1.6 -0.2 -0.2 1.7 1.5
Had menopause 0.4 0.5 1.7 0.1 0.3 1.3 1.2 -0.6 0.5 0.6 0.5 0.6
Had other major operations 1.3 1.6 4.3 0.0 2.1 1.7 0.3 -0.8 1.8 1.8 0.3 0.4
Forced vital capacity (FVC) 3.2 12.3 25.2 0.4 4.6 4.6 3.1 -2.1 1.4 1.3 5.0 5.0
Heel bone mineral density (BMD) T-score, automated (right) 8.7 20.0 67.6 -4.0 1.7 4.2 -1.0 -2.5 -3.8 -3.7 8.2 6.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.8 0.1 0.4 1.4 0.1 -1.8 -0.6 -0.6 2.0 1.2
Qualifications: None of the above 0.6 1.3 3.3 0.5 -1.6 -0.7 -0.4 -1.6 -0.6 -0.6 -1.3 -1.8
Financial difficulties in last 2 years 0.3 0.4 1.1 0.2 -0.5 0.2 1.0 0.4 0.8 0.9 -0.9 0.0
Mouth/teeth dental problems 5.5 8.4 16.6 -2.0 2.8 1.4 4.1 2.6 3.5 3.4 -0.1 3.7
Heart attack 0.5 0.6 1.4 0.3 0.2 1.0 1.2 -0.7 1.0 1.1 -0.3 0.3
Allergy 0.3 0.7 2.4 -0.8 -0.1 -0.4 0.3 1.6 -0.2 -0.3 0.5 1.5
Pain all over the body in last month 0.6 0.6 2.2 -1.5 -1.2 -0.4 1.2 -0.1 -0.2 -0.3 -0.2 -0.2
Diabetes (self-reported) 0.7 1.1 3.8 -2.0 -1.7 -0.1 -1.1 0.7 -0.8 -0.9 -0.3 -0.2
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 9.2 2.0 -0.5 -0.6 0.9 -0.4 1.7 1.6 -3.0 -2.6
Medication: Ramipril 1.8 2.3 5.8 -1.0 -2.4 -2.0 -1.3 -0.2 -1.8 -1.9 -0.8 -0.7
Medication: Simvastatin 0.5 0.8 3.7 -0.5 -1.3 -0.6 0.4 0.4 0.5 0.4 -1.9 -0.7
Fluid intelligence score 3.9 8.0 14.5 2.3 3.8 3.1 3.5 -1.2 3.8 3.8 0.4 0.7
Illnesses of siblings 3.3 4.7 13.7 0.8 3.7 1.7 1.8 1.1 2.5 2.4 1.0 2.7
Neuroticism score 3.0 6.2 13.5 2.3 0.3 -0.2 3.0 -0.4 3.5 3.6 -3.7 -1.7
Weight 0.6 3.1 9.6 -3.1 -2.4 -0.2 -1.0 0.4 -2.3 -2.2 1.1 0.6
Impedance of arm (right) 0.5 2.3 7.9 2.8 -0.5 -0.3 -1.6 -1.5 -0.3 -0.4 -0.9 -2.5
Arm fat percentage (right) 3.8 15.2 30.4 -4.4 -5.5 -3.7 -4.8 1.8 -3.8 -3.7 -2.4 -3.5
Trunk fat-free mass 1.5 8.5 28.1 -1.3 1.4 3.3 2.1 -0.9 -1.0 -1.0 5.2 5.3
Hip circumference 1.5 6.4 12.6 -3.5 -3.3 -2.9 -1.9 3.0 -1.4 -1.4 -2.5 -1.7
Time employed in main current job 0.9 1.1 3.7 -0.1 1.7 0.9 -0.5 -1.0 -0.5 -0.5 1.9 0.8
Alcohol intake versus 10 years previously 0.7 1.1 3.7 -0.2 -0.7 -0.4 -1.9 -0.3 -1.5 -1.5 0.4 -0.5
Father’s age at death 0.6 0.8 2.4 0.1 0.3 -1.1 -0.0 1.6 0.6 0.6 -1.5 -0.8
Worrier / anxious feelings 0.2 0.4 1.3 0.9 -0.3 -0.8 -0.5 -0.4 -0.2 -0.2 -0.8 -1.2
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 10.0 1.6 0.4 -0.6 2.2 1.2 3.0 3.0 -3.2 -1.3
Falls in the last year 0.5 0.6 3.9 -0.1 -1.2 -0.2 2.0 -0.6 0.0 0.0 -0.4 0.2
Hair/balding pattern: Pattern 3 2.8 4.2 8.8 -1.7 -1.9 -3.0 -2.0 2.2 -0.8 -0.7 -2.4 -2.6
Number of live births 1.4 2.0 4.3 0.2 -1.5 0.3 -1.0 -2.0 -2.1 -2.1 1.3 -0.2
Forced expiratory volume in 1-second (FEV1) 2.7 9.3 23.9 -0.1 4.9 3.5 2.1 -0.7 1.7 1.6 3.9 4.6
Pulse rate 1.3 2.2 4.5 -1.3 1.5 1.8 1.8 0.8 1.2 1.2 1.2 2.1
Happiness 0.9 1.1 3.6 1.1 -1.3 -0.4 0.8 0.5 1.0 0.9 -1.9 -0.9
Noisy workplace 0.8 0.9 2.7 0.0 -0.9 0.1 -0.5 -1.6 -1.3 -1.3 1.0 0.4
Qualifications: A levels/AS levels or equivalent 2.2 4.9 11.0 0.3 3.2 0.7 2.2 2.4 3.3 3.3 -1.0 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.6 -0.7 0.7 -1.2 -0.2 1.1 0.4 0.4 -0.7 -0.0
Mouth/teeth dental problems: Dentures 0.7 1.2 5.1 0.3 0.8 2.3 0.2 -1.7 0.3 0.4 1.1 -0.2
Asthma 0.7 1.5 5.3 -0.1 -0.4 -0.5 1.2 0.6 1.5 1.5 -2.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 12.0 1.3 3.5 0.9 1.5 0.3 3.2 3.2 -0.6 0.5
Medication: Cholesterol lowering 0.5 0.7 3.3 0.3 -1.8 -0.6 -0.3 -0.6 -0.5 -0.5 -1.0 -0.9
Depression (self-reported) 0.9 1.1 3.5 -0.4 0.1 0.7 1.9 -0.2 1.4 1.4 -0.2 1.2
Medication: Lansoprazole 0.4 0.4 1.6 -0.1 -0.5 -0.4 -0.1 0.5 0.3 0.4 -1.1 -1.3
Prospective memory result 5.7 7.0 14.4 -1.8 -3.8 -2.9 -2.4 0.1 -3.7 -3.7 -0.0 -1.9
Lung cancer (father) 1.8 2.1 5.4 1.0 0.5 2.3 0.9 -1.9 -0.6 -0.6 2.2 1.3
Illnesses of mother 0.3 0.3 1.2 -0.0 0.8 0.2 -0.4 0.5 0.1 0.1 1.1 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.4 24.6 0.6 5.0 3.6 1.7 -0.9 1.3 1.1 4.5 4.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.7 0.1 -0.2 -0.1 1.3 -0.1 0.9 0.9 -1.1 -0.4
Impedance of arm (left) 0.6 2.8 10.2 3.2 -0.6 -0.6 -1.1 -1.5 -0.1 -0.1 -1.3 -3.0
Arm fat mass (right) 2.3 9.5 20.0 -4.3 -4.5 -2.5 -3.4 1.5 -3.4 -3.3 -1.1 -1.8
Trunk predicted mass 1.4 8.2 26.9 -1.3 1.3 3.2 2.1 -0.9 -1.1 -1.0 5.1 5.2
Standing height 2.1 20.4 37.5 4.0 4.4 6.1 4.7 -4.5 1.4 1.4 6.1 5.3
Length of working week for main job 0.4 0.5 2.2 0.1 0.3 0.9 0.3 -0.1 -0.0 -0.1 1.5 1.0
Exposure to tobacco smoke at home 2.1 2.4 5.9 -0.7 -1.8 -2.4 -1.9 0.6 -1.6 -1.5 -1.0 -1.5
Breastfed as a baby 1.8 2.3 6.4 -0.6 1.6 2.2 1.1 -0.3 0.2 0.1 2.5 2.2
Tense / ‘highly strung’ 0.5 0.8 3.0 0.1 -0.6 -1.3 -0.4 -0.7 -0.2 -0.1 -1.4 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.4 5.3 2.3 -2.3 -1.0 1.2 -0.6 0.5 0.4 -1.8 -2.0
Hair/balding pattern: Pattern 4 1.1 2.8 10.0 0.1 -1.4 -1.5 1.6 1.5 1.3 1.2 -3.2 -1.6
Birth weight of first child 2.1 3.8 13.1 0.2 3.6 2.4 0.9 0.4 1.9 1.8 1.6 2.2
Peak expiratory flow (PEF) 1.8 4.2 10.2 -0.3 3.0 1.9 2.4 0.0 1.6 1.5 2.0 3.2
Pulse wave reflection index 0.4 0.5 1.5 0.1 -1.2 -0.8 -0.0 -0.2 -0.1 -0.1 -1.2 -0.9
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.1 -0.2 0.9 1.2 1.8 -0.9 1.4 1.4 0.7 1.0
Loud music exposure frequency 1.1 1.2 3.8 -1.4 -0.9 -1.0 -1.9 0.4 -1.3 -1.1 -0.2 -0.7
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.5 1.2 1.5 0.0 0.8 0.9 2.0 2.1 -1.4 -1.1
Mouth/teeth dental problems: Bleeding gums 13.7 17.7 42.5 1.5 -4.6 -4.0 -6.5 -1.2 -5.2 -5.2 -0.8 -4.5
Blood clot in the leg (DVT) 3.4 4.4 10.5 2.0 2.1 3.0 1.7 -3.2 0.7 0.8 2.7 0.7
Medication: Paracetamol 1.9 3.2 7.6 -1.0 2.8 1.1 1.8 0.3 2.6 2.6 -0.2 1.4
Headache pain in last month 2.6 4.5 14.3 1.5 3.8 1.0 1.5 -0.3 3.1 3.2 -0.6 0.8
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 10.8 0.0 3.3 1.9 0.4 0.1 0.8 0.8 2.4 2.0
Glaucoma (self-reported) 5.5 6.5 16.4 -0.5 4.1 3.5 2.1 -0.6 2.5 2.6 2.0 2.9
Gout (self-reported) 0.5 0.7 2.5 0.7 -1.6 -0.7 -0.6 -0.3 -0.6 -0.7 -0.7 -0.9
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 5.8 -0.7 -2.4 -1.3 -0.7 -0.3 -0.8 -0.8 -1.4 -1.1
Medication: Amlodipine 4.8 6.7 21.2 0.7 -4.6 -2.8 -1.8 -0.5 -1.8 -1.8 -2.9 -3.5
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.4 1.0 -0.2 0.9 1.2 -0.9 1.2 1.2 -0.8 -0.8
Birth weight 2.0 4.3 8.5 -0.2 2.6 2.7 2.5 -0.8 1.6 1.6 2.1 2.9
Chronic bronchitis/emphysema (mother) 1.4 1.6 6.1 1.1 -1.4 1.0 0.1 -2.5 -1.3 -1.3 0.8 -0.6
High blood pressure (siblings) 2.1 3.1 6.0 -0.7 -2.5 -2.0 -1.5 -1.5 -1.8 -1.7 -1.2 -2.2
Forced vital capacity (FVC), Best measure 3.4 12.6 33.6 1.0 4.7 4.5 2.2 -2.5 0.7 0.5 5.8 5.0
Body fat percentage 3.0 11.7 25.4 -3.3 -5.0 -3.2 -4.0 1.1 -2.9 -2.8 -2.9 -4.1
Leg fat percentage (right) 2.8 10.2 19.4 -3.4 -4.4 -3.0 -3.9 1.2 -2.4 -2.4 -3.0 -3.9
Arm fat-free mass (right) 0.8 4.0 11.8 -1.4 0.6 2.4 1.9 -0.8 -0.5 -0.5 3.4 3.4
Exposure to tobacco smoke outside home 2.5 3.3 10.1 0.5 -1.5 -2.4 -2.2 0.9 -0.8 -0.7 -2.1 -3.2
Comparative body size at age 10 3.2 8.7 18.5 -3.7 -4.3 -3.2 -2.7 1.0 -3.5 -3.5 -0.4 -1.5
Number of full brothers 0.8 1.0 3.9 -0.7 -2.0 -0.6 0.2 -0.5 -1.5 -1.4 0.4 -0.1
Worry too long after embarrassment 0.2 0.3 0.6 0.8 -0.5 -0.8 0.4 -0.4 0.2 0.2 -0.7 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 -0.1 -0.3 0.6 0.7 -0.3 0.3 0.2 0.3 0.6
Wheeze or whistling in the chest in last year 0.9 1.6 5.2 1.1 -1.9 0.8 -0.1 -2.3 -0.5 -0.5 -0.5 -1.6
Number of children fathered 2.3 2.6 6.8 -1.0 -0.6 0.1 -1.7 -0.8 -2.6 -2.6 2.1 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 3.2 -0.3 -1.8 -0.6 0.3 0.0 -1.2 -1.2 0.1 0.1
Age at first live birth 3.5 6.2 14.1 0.2 2.9 1.2 3.2 1.9 3.7 3.8 -1.3 1.6
Pulse wave peak to peak time 0.5 0.6 1.8 0.2 0.4 0.6 -1.0 -0.2 -0.7 -0.8 1.4 0.7
Health satisfaction 0.3 0.3 0.9 0.6 -0.6 -0.2 0.4 -0.9 0.4 0.4 -0.8 -0.5
Shortness of breath walking on level ground 1.4 1.7 4.9 0.8 -0.8 -0.7 0.9 0.1 1.2 1.3 -2.2 -2.1
Qualifications: College or University degree 0.8 2.6 5.8 -0.4 1.4 0.4 2.2 1.5 2.4 2.3 -0.6 1.7
Eye problems/disorders: None of the above 0.4 0.5 1.4 1.2 0.8 -0.3 0.4 0.1 0.9 0.9 -0.5 -0.5
Mouth/teeth dental problems: Loose teeth 2.4 2.9 5.8 2.3 -2.4 -1.0 -0.9 -1.9 -1.3 -1.3 -0.6 -2.3
Emphysema/chronic bronchitis 0.4 0.4 1.2 0.2 -0.9 -0.2 -0.4 -1.1 -0.7 -0.7 -0.0 -0.7
Medication for pain relief, constipation, heartburn 0.4 0.7 1.5 0.1 -1.2 0.5 0.0 -0.5 -1.2 -1.2 1.1 0.5
Neck or shoulder pain in last month 1.7 2.4 5.8 0.9 1.6 1.2 2.0 -0.4 2.4 2.4 -0.8 0.5
Medication: Blood pressure 2.5 4.4 13.6 -0.7 -3.7 -2.9 -0.3 0.0 -0.7 -0.7 -3.3 -2.3
Angina (self-reported) 0.5 0.7 2.9 0.4 -0.1 -0.6 -0.4 0.3 0.7 0.6 -1.7 -1.3
Migraine (self-reported) 7.9 9.8 20.5 1.7 4.5 2.8 4.5 -0.4 3.5 3.6 1.3 3.2
Medication: Ibuprofen 2.4 2.8 9.0 -0.0 3.0 0.4 1.0 1.1 2.5 2.6 -0.6 0.6
Medication: Allopurinol 0.8 1.1 3.8 0.3 -1.7 -1.9 -0.4 0.7 -0.5 -0.6 -1.3 -0.8
Medication: Omeprazole 0.7 0.8 2.2 -1.5 0.8 1.0 -0.0 1.2 0.2 0.2 0.7 1.3
Medication: Seretide 50 evohaler 0.3 0.3 1.2 0.2 -1.1 0.1 0.2 -0.8 -0.6 -0.5 0.3 0.1
Mean time to correctly identify matches 7.8 14.9 35.3 -0.8 -3.0 1.6 -3.9 -2.9 -5.9 -5.8 5.3 1.0
Heart disease (mother) 1.3 1.5 3.3 -0.4 -1.5 -0.2 -1.8 -1.0 -1.7 -1.7 0.0 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.0 0.8 -0.6 -0.6 0.4 -0.8 0.9 0.9 -1.7 -1.4
Whole body fat mass 1.8 7.6 17.7 -3.5 -4.2 -2.2 -3.0 0.8 -3.0 -2.9 -1.2 -2.3
Leg fat mass (right) 1.8 6.8 15.3 -3.9 -3.9 -2.0 -2.7 1.0 -2.6 -2.5 -1.3 -1.9
Arm predicted mass (right) 0.8 4.2 12.1 -1.5 0.6 2.4 1.8 -0.8 -0.6 -0.6 3.5 3.5
Pulse rate, automated reading 2.1 6.9 12.5 -3.0 2.1 3.4 3.3 1.4 2.0 2.0 2.0 3.5
Alcohol intake frequency. 0.4 0.9 2.3 -1.5 1.3 1.1 -1.2 -0.2 0.7 0.7 0.6 0.7
Comparative height size at age 10 2.0 10.9 28.0 1.7 2.4 4.4 2.9 -4.0 -0.2 -0.2 5.3 4.2
Number of full sisters 0.7 0.8 2.6 -0.8 -0.5 -0.4 -1.6 -0.5 -1.2 -1.2 0.8 0.5
Suffer from ‘nerves’ 4.0 6.3 13.9 2.9 1.6 1.3 3.3 0.1 3.7 3.7 -2.4 -0.8
Overall health rating 1.2 2.5 6.8 -0.5 -1.2 0.3 2.6 -0.6 2.0 2.0 -2.2 -1.0
Chest pain or discomfort 1.6 2.3 6.3 2.1 0.6 1.9 1.6 -2.5 1.2 1.2 0.1 -0.4
Had major operations 1.8 2.1 4.2 2.0 0.5 -0.9 1.3 0.4 1.9 1.8 -2.0 -1.0
Age at last live birth 2.3 3.4 7.5 0.6 2.2 1.9 2.7 0.5 2.1 2.1 0.4 2.3
Family relationship satisfaction 0.8 0.9 4.4 2.1 -0.9 0.5 0.2 -1.5 -0.5 -0.5 0.1 -0.6
Leg pain on walking 1.1 1.4 2.4 1.4 0.2 1.1 1.5 -1.6 1.4 1.4 -0.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 7.0 -1.9 0.9 1.2 -1.5 -0.1 -1.4 -1.3 2.6 1.8
Commuting to job workplace: Car/motor vehicle 1.7 1.9 6.4 -0.8 1.2 1.1 -1.5 -0.8 -1.3 -1.3 2.5 1.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 0.9 -0.5 0.2 -0.3 0.1 -0.4 -0.4 0.1 -0.5
Medication: Aspirin 1.0 1.4 4.7 1.1 -2.2 -1.1 -0.4 -0.7 -0.9 -0.9 -1.2 -1.1
Supplements: Vitamin C 0.6 0.7 1.9 0.9 1.0 0.2 -0.9 -0.5 -0.8 -0.9 1.4 0.2
Knee pain experienced in last month 1.1 1.8 4.6 0.3 2.1 1.7 1.1 -0.1 0.7 0.7 1.7 1.8
Hypertension (Self-reported) 7.1 19.8 43.2 0.1 -6.4 -6.6 -2.7 -0.2 -2.3 -2.2 -6.3 -6.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 3.4 1.5 1.9 1.1 0.5 -0.2 0.5 0.4 1.0 0.4
Illnesses of father: Heart disease 0.5 0.7 1.9 -0.1 -1.2 -0.4 0.7 0.8 0.3 0.3 -1.4 -1.2
Illnesses of siblings: Diabetes 1.3 1.6 3.3 -0.2 -1.8 -1.2 -1.6 1.1 -1.5 -1.4 -0.6 -1.2
Smoking status: Previous 0.7 1.1 2.6 -0.5 -1.6 -0.4 -0.7 -0.1 -1.6 -1.6 1.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.7 14.0 1.0 3.0 3.0 1.8 -1.0 0.5 0.5 3.6 3.7
Whole body fat-free mass 1.0 5.9 18.7 -2.1 0.2 2.2 1.3 -0.2 -1.6 -1.5 4.2 4.3
Leg fat-free mass (right) 0.8 4.5 9.5 -3.1 -1.4 0.7 0.2 0.6 -2.3 -2.3 3.0 2.9
Arm fat percentage (left) 4.1 16.2 32.9 -4.4 -5.7 -4.0 -4.8 2.0 -3.7 -3.6 -2.8 -3.9
Average weekly red wine intake 0.2 0.3 1.2 -0.6 0.3 0.1 -0.1 1.1 0.3 0.3 0.3 0.7
Handedness (chirality/laterality): Left-handed 0.7 0.8 3.0 1.7 -0.8 -1.0 -0.5 0.5 -0.7 -0.6 -0.4 -1.0
Mood swings 2.0 3.6 12.5 1.8 -1.0 -1.3 1.0 -0.6 1.7 1.7 -3.5 -2.6
Loneliness, isolation 3.9 5.4 12.0 3.5 0.5 0.8 3.0 -0.9 3.1 3.1 -2.3 -1.0
Long-standing illness, disability or infirmity 0.4 0.6 1.3 -1.0 -0.9 0.6 1.1 -1.1 -0.3 -0.4 0.6 0.7
Ever had bowel cancer screening 0.3 0.4 1.2 0.2 0.2 0.7 -1.1 0.3 -0.6 -0.5 0.8 -0.2
Diabetes diagnosed by doctor 0.5 0.9 4.5 -2.1 -1.0 0.6 -0.9 0.2 -0.6 -0.7 0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.9 0.7 0.7 -0.3 -0.5 -0.1 -0.2 0.8 0.5
Friendships satisfaction 1.6 2.0 4.8 1.9 0.1 1.7 2.2 -1.4 1.4 1.5 -0.0 0.4
Qualifications: nursing, teaching 0.7 1.1 3.0 0.1 -1.2 -1.5 0.7 1.7 0.3 0.3 -1.6 -0.4
Commuting to job workplace: Walk 1.9 2.0 4.8 1.0 0.3 -0.0 1.8 -0.3 2.1 2.2 -1.9 -0.9
Eye problems/disorders: Cataract 0.4 0.4 2.0 -1.1 -1.4 0.2 0.1 -0.1 -0.5 -0.5 0.1 0.3
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 4.0 0.5 -1.4 -1.6 -1.8 -0.3 -2.0 -1.9 0.3 -1.2
Medication for cholesterol 2.6 4.0 11.2 0.9 3.4 2.5 1.7 -0.0 1.8 1.9 1.9 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.1 4.8 10.9 -1.7 -2.3 -1.8 -3.3 0.3 -3.1 -3.1 0.8 -0.9
Back pain experienced in last month 3.4 5.0 13.4 1.2 2.7 -0.1 2.1 0.5 3.7 3.7 -2.0 0.5
Mineral and other dietary supplements 0.3 0.3 1.9 0.0 0.1 0.4 0.8 -1.4 0.3 0.3 0.3 0.3
Breast cancer (self-reported) 0.2 0.2 1.1 -1.0 -0.1 0.2 0.0 0.2 -0.5 -0.4 0.4 0.2
Asthma (self-reported) 0.6 1.3 4.8 0.1 -0.4 -0.4 1.1 0.3 1.4 1.4 -2.2 -1.0
Osteoporosis (self-reported) 2.9 3.7 9.3 0.8 1.1 -0.2 1.7 1.2 3.1 3.0 -2.5 -1.4
Osteoarthritis (self-reported) 1.0 1.3 2.3 -1.1 0.9 0.7 1.5 1.0 1.5 1.5 -0.4 1.1
Medication: Aspirin 0.9 1.1 4.2 0.4 -2.1 -0.9 -0.6 -0.6 -1.2 -1.3 -0.8 -0.7
Medication: Gliclazide 1.4 1.6 4.8 -0.1 -2.2 -0.4 -1.2 -0.5 -1.7 -1.8 0.3 -1.2
Illnesses of father: None of the above (group 1) 1.1 1.4 4.2 1.3 1.3 0.8 -1.3 -1.2 -0.6 -0.6 2.0 0.4
Smoking status: Current 2.2 3.5 14.5 3.8 -0.5 1.6 1.4 -3.4 0.4 0.4 0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 4.0 -0.2 1.4 -0.3 -2.0 -0.3 -1.3 -1.5 1.9 0.7
Whole body water mass 1.0 5.8 18.5 -2.0 0.4 2.4 1.4 -0.3 -1.4 -1.4 4.2 4.3
Leg predicted mass (right) 0.9 4.6 9.6 -3.0 -1.3 0.7 0.2 0.6 -2.4 -2.3 3.1 2.9
Arm fat mass (left) 2.1 8.7 18.7 -4.3 -4.3 -2.3 -3.1 1.4 -3.3 -3.2 -0.9 -1.6
Number of self-reported non-cancer illnesses 2.1 3.7 10.8 1.4 -0.5 -0.6 2.4 -0.3 2.6 2.5 -3.3 -1.2
Average weekly champagne plus white wine intake 1.5 2.0 6.8 2.6 0.6 0.3 -1.6 -2.1 -0.7 -0.7 0.7 -1.6
Miserableness 4.0 7.0 23.2 2.9 -0.8 -1.4 1.7 0.1 3.0 2.9 -4.8 -2.8
Guilty feelings 1.4 2.1 3.8 1.9 -1.7 -1.2 1.6 -1.6 0.6 0.6 -2.0 -1.2
Wears glasses or contact lenses 0.5 0.5 1.9 -1.4 -0.8 0.2 0.5 0.1 -0.8 -0.7 0.5 0.8
Ever taken oral contraceptive pill 4.5 5.0 11.3 -0.6 3.4 1.6 2.3 2.1 2.8 2.8 0.3 2.3
Hearing aid user 2.0 2.3 5.4 -0.2 -2.3 -2.0 -1.6 -0.1 -1.7 -1.7 -0.9 -1.5
Mother’s age at death 0.7 0.8 2.6 -0.3 1.4 -0.4 -0.3 1.6 0.9 0.9 -0.8 -0.4
Financial situation satisfaction 0.4 0.5 1.3 0.5 0.4 0.8 1.1 -0.2 0.9 0.9 0.1 0.2
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.6 1.6 -0.3 0.2 -0.3 -1.5 -0.4 -0.4 0.1 -0.4
Commuting to job workplace: Public transport 0.5 0.6 1.6 -0.1 -0.0 -0.5 1.2 0.6 0.9 0.9 -1.2 0.1
Eye problems/disorders: Glaucoma 6.5 7.7 18.6 0.1 4.0 4.3 2.5 -1.1 2.7 2.7 2.2 2.7
Medication: Blood pressure 5.7 10.9 23.9 0.2 -4.0 -4.9 -3.6 -0.1 -2.6 -2.6 -3.7 -4.3
Pain type(s) experienced in last month: Hip pain 1.1 1.4 4.6 -0.0 0.9 0.4 2.1 0.2 1.7 1.7 -0.6 1.1
Supplements: Fish oil (including cod liver oil) 1.5 1.9 4.1 -1.4 -0.8 -1.0 -2.0 1.8 -1.7 -1.7 0.6 0.6
High cholesterol (Self-reported) 1.2 2.2 6.5 1.0 -2.5 -1.2 -0.5 -0.8 -0.5 -0.5 -2.0 -2.3
Medication: Bendroflumethiazide 3.0 4.6 10.8 0.7 -2.6 -3.3 -1.5 -0.6 -0.9 -0.9 -3.1 -3.1
Medication: Paracetamol 1.5 2.3 6.2 -1.2 2.5 0.9 1.3 0.4 2.0 2.0 0.2 1.4
Medication: Lisinopril 2.6 3.4 10.0 0.6 -2.2 -2.2 -0.8 -0.4 0.2 0.3 -3.2 -3.2
Medication: Atorvastatin 0.7 0.9 3.2 -1.2 -1.8 -0.3 -0.8 0.2 -1.1 -1.1 0.0 0.1
Illnesses of father: High blood pressure 1.4 1.7 3.6 0.2 -1.5 -1.7 -0.6 -1.9 -1.4 -1.3 -0.9 -1.3
Alcohol drinker status: Never 0.3 0.3 1.2 -0.4 -0.1 -0.3 -1.1 0.0 0.0 0.1 -0.6 -1.0
Ever smoked 0.6 1.1 3.1 1.6 -1.2 0.5 1.0 -1.8 -0.6 -0.6 0.8 0.2
Basal metabolic rate 0.8 4.4 12.2 -2.5 -0.5 1.6 0.7 -0.1 -1.8 -1.8 3.5 3.4
Leg fat percentage (left) 3.2 11.5 23.1 -3.5 -4.8 -3.3 -4.1 1.0 -2.8 -2.7 -2.9 -4.0
Arm fat-free mass (left) 0.8 3.9 12.5 -1.8 0.5 2.3 1.6 -0.3 -0.7 -0.6 3.3 3.5
Number of operations (self-reported) 0.4 0.5 1.7 0.7 1.3 0.5 0.1 -0.2 1.0 1.0 0.1 -0.2
Average weekly beer plus cider intake 1.4 2.0 5.8 0.4 -1.1 1.0 -0.0 -2.4 -1.7 -1.7 2.1 0.3
Irritability 0.6 1.0 2.4 -0.7 1.1 0.5 1.1 -0.1 1.6 1.6 -0.8 -0.2
Risk taking 0.6 0.9 2.9 -0.2 -0.3 0.5 0.8 -0.4 -0.8 -0.9 1.7 1.5
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.6 1.5 -0.4 -1.0 1.2 1.5 0.8 0.8 -1.6 -0.7
Fractured/broken bones in last 5 years 1.3 1.7 6.5 2.5 -0.1 -1.1 0.7 0.4 1.1 1.1 -1.7 -1.1
Age started oral contraceptive pill 0.6 0.8 2.0 1.4 0.2 -0.7 -0.4 0.7 0.2 0.2 -1.2 -1.4
Diastolic blood pressure, automated reading 1.4 4.4 11.9 0.7 -3.5 -2.6 0.8 -1.6 -0.2 -0.2 -3.3 -2.4
Ever depressed for a whole week 0.1 0.1 0.6 -0.1 -0.2 0.3 0.3 -0.3 -0.2 -0.2 0.8 0.5
Unable to work because of sickness or disability 0.5 0.6 1.4 -1.1 -1.0 0.2 1.2 -0.7 -0.3 -0.3 0.4 1.0
Commuting to job workplace: Cycle 0.7 0.8 3.1 -1.8 -0.6 -0.6 -0.1 1.6 -0.3 -0.3 -0.3 0.8
Myopia 1.7 2.4 6.2 2.4 0.4 1.5 1.5 -2.5 -0.5 -0.5 2.1 0.7
Vascular/heart problems diagnosed by doctor 5.7 15.5 39.1 -0.4 5.5 5.7 1.9 0.1 1.4 1.3 6.3 5.5
Cholesterol lowering medication 1.0 1.5 5.3 -0.6 -1.4 -1.2 -0.9 0.2 0.1 0.0 -2.3 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.7 -1.3 0.7 0.8 -0.3 0.9 0.1 0.2 0.5 1.0
Pain experienced in last month 2.2 3.7 9.0 -1.7 -2.3 0.1 -1.7 -0.6 -3.0 -3.0 1.9 0.3
Supplements: Calcium 1.4 1.5 4.0 1.8 0.7 0.3 2.0 0.8 1.6 1.6 -0.5 -0.2
Basal cell carcinoma (self-reported) 2.2 2.6 6.1 0.2 -2.4 -2.5 -0.9 0.7 -1.3 -1.3 -1.8 -2.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.1 0.6 0.2 1.3 1.4 -1.2 1.1 1.1 -0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 3.1 3.9 10.8 1.8 1.9 2.7 1.4 -3.3 0.2 0.3 2.8 0.8
Heart disease (siblings) 0.8 0.9 1.9 -0.5 -0.8 1.1 -0.4 -1.2 -1.2 -1.2 1.4 0.0
Alcohol drinker status: Previous 0.9 1.0 3.1 1.1 -1.8 0.3 0.2 -0.6 0.7 0.7 -1.3 -1.3
Pack years of smoking 1.4 2.0 8.1 0.3 -2.8 -0.1 0.2 -2.1 -1.6 -1.6 0.5 -0.5
Impedance of whole body 1.0 4.9 19.0 4.4 1.0 0.4 -0.3 -2.5 1.6 1.6 -1.8 -3.1
Leg fat mass (left) 1.9 7.5 17.1 -3.9 -4.1 -2.0 -2.9 0.7 -3.0 -2.9 -0.9 -1.9
Arm predicted mass (left) 0.7 3.4 10.6 -1.5 0.6 2.2 1.4 -0.5 -0.6 -0.6 3.1 3.3