Best TWAS P=1.82e-09 · Best GWAS P=1.99e-09 conditioned to 0.0243
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | OGFOD2 | 0.10 | 0.07 | lasso | 7 | 0.07 | 3.1e-06 | 5.5 | 5.2 | 2.3e-07 | 0.93 | 0.09 | 0.91 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | ABCB9 | 0.08 | 0.12 | enet | 7 | 0.12 | 4.3e-09 | 5.3 | 5.4 | 7.3e-08 | 0.89 | 0.28 | 0.71 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | ARL6IP4 | 0.12 | 0.13 | lasso | 2 | 0.12 | 4.0e-09 | 5.3 | -5.3 | 1.3e-07 | -0.85 | 0.15 | 0.85 | FALSE |
4 | GTEx | Heart Left Ventricle | ABCB9 | 0.10 | 0.14 | lasso | 5 | 0.10 | 4.2e-06 | 6.0 | 5.9 | 3.2e-09 | 0.95 | 0.01 | 0.99 | FALSE |
5 | GTEx | Liver | ABCB9 | 0.32 | 0.32 | lasso | 3 | 0.28 | 1.9e-08 | 5.3 | 5.3 | 1.2e-07 | 0.88 | 0.12 | 0.85 | FALSE |
6 | GTEx | Pancreas | ARL6IP4 | 0.07 | 0.07 | lasso | 2 | 0.07 | 9.6e-04 | 6.0 | -5.4 | 6.1e-08 | -0.93 | 0.04 | 0.88 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | ABCB9 | 0.13 | 0.15 | lasso | 11 | 0.11 | 2.1e-06 | 5.3 | 5.5 | 4.7e-08 | 0.93 | 0.03 | 0.97 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | ABCB9 | 0.09 | 0.08 | lasso | 5 | 0.08 | 4.3e-07 | 5.3 | 5.7 | 1.3e-08 | 0.93 | 0.03 | 0.97 | FALSE |
9 | GTEx | Testis | MPHOSPH9 | 0.28 | 0.27 | enet | 23 | 0.32 | 1.3e-14 | 4.7 | 5.2 | 2.5e-07 | 0.93 | 0.07 | 0.93 | FALSE |
10 | GTEx | Testis | CDK2AP1 | 0.20 | 0.14 | lasso | 5 | 0.13 | 2.0e-06 | 5.8 | -5.9 | 3.3e-09 | -0.95 | 0.01 | 0.99 | FALSE |
11 | GTEx | Testis | RP11-282O18.3 | 0.18 | 0.09 | lasso | 9 | 0.12 | 7.8e-06 | 5.8 | -5.3 | 1.3e-07 | -0.85 | 0.02 | 0.96 | FALSE |
12 | NTR | Blood | SBNO1 | 0.02 | 0.02 | lasso | 2 | 0.02 | 5.5e-07 | 5.2 | -5.2 | 1.7e-07 | -0.85 | 0.13 | 0.87 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | OGFOD2 | 0.03 | 0.02 | blup | 16 | 0.01 | 5.0e-02 | 5.2 | 5.4 | 5.3e-08 | 0.86 | 0.01 | 0.85 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C12orf65 | 0.02 | 0.00 | enet | 6 | 0.01 | 2.4e-03 | 6.0 | -5.6 | 1.7e-08 | -0.82 | 0.01 | 0.81 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C12orf65 | 0.04 | 0.03 | enet | 18 | 0.03 | 4.9e-04 | 5.8 | -6.0 | 1.8e-09 | -0.75 | 0.01 | 0.91 | TRUE |
16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C12orf65 | 0.05 | 0.04 | blup | 34 | 0.05 | 1.0e-03 | 5.3 | -5.9 | 4.6e-09 | -0.95 | 0.01 | 0.91 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C12orf65 | 0.03 | 0.01 | blup | 35 | 0.02 | 1.6e-03 | 5.8 | -5.8 | 5.9e-09 | -0.89 | 0.01 | 0.87 | FALSE |
18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABCB9 | 0.19 | 0.22 | enet | 9 | 0.22 | 7.7e-11 | 5.2 | 5.7 | 1.6e-08 | 0.88 | 0.01 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ABCB9 | 0.06 | 0.06 | enet | 7 | 0.07 | 5.2e-08 | 5.3 | 5.3 | 1.5e-07 | 0.91 | 0.01 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABCB9 | 0.04 | 0.05 | enet | 10 | 0.05 | 1.2e-05 | 5.0 | 5.2 | 2.1e-07 | 0.90 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CDK2AP1 | 0.13 | 0.10 | blup | 34 | 0.11 | 8.2e-05 | 5.8 | -5.4 | 8.4e-08 | -0.93 | 0.01 | 0.97 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | OGFOD2 | 0.02 | 0.00 | enet | 4 | 0.02 | 2.7e-03 | 5.3 | 5.6 | 2.2e-08 | 0.88 | 0.01 | 0.68 | FALSE |
23 | The Cancer Genome Atlas | Thyroid Carcinoma | PITPNM2 | 0.04 | 0.03 | enet | 5 | 0.05 | 8.1e-06 | 3.7 | 5.7 | 1.2e-08 | 0.78 | 0.03 | 0.97 | FALSE |