Hub : Genes

PITPNM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.114 0.0502 4.6e-03 0.050 NA 0.042 NA 0.043 8.4e-05 NA 3.2e-04 NA 2.7e-04
2 GTEx Brain Cerebellar Hemisphere 0.187 0.0950 5.7e-03 0.149 NA 0.036 NA 0.062 1.2e-04 NA 4.2e-02 NA 1.1e-02
3 GTEx Thyroid 0.041 0.0180 2.4e-03 0.072 NA 0.046 NA 0.062 3.6e-06 NA 2.0e-04 NA 1.6e-05
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.061 0.0320 3.8e-05 0.069 0.085 0.080 NA 0.086 9.0e-05 1.4e-05 2.5e-05 NA 1.2e-05
5 TCGA Thyroid Carcinoma 0.040 0.0240 4.6e-05 0.031 0.044 0.052 NA 0.047 5.2e-04 3.6e-05 8.1e-06 NA 2.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 3.0 4.7 6.9 0.0 -2.6 2.3 -2.2 2.6
Bipolar Disorder or Schizophrenia 9.1 22.3 36.7 0.0 -5.2 4.7 -5.1 6.1
Depressed Affect (Nagel 2018) 2.3 4.9 9.6 1.0 0.7 -3.1 2.9 -2.2
Depression (Nagel 2018) 0.5 0.8 2.9 0.5 0.1 -0.9 1.7 -0.1
Intelligence (Savage-Jansen 2018) 7.0 21.5 27.4 -3.3 -5.2 5.1 -5.2 4.1
Neuroticism (Nagel 2018) 1.3 3.1 5.3 1.1 0.2 -2.3 2.3 -1.9
Schizophrenia (2018) 9.1 18.8 32.6 0.0 -4.6 4.1 -4.8 5.7
Schizophrenia vs Biploar Disorder 3.2 4.2 9.0 0.0 -1.3 2.4 -2.2 3.0
Worry (Nagel 2018) 0.4 0.9 1.7 0.3 -0.1 -1.0 1.2 -1.3
Alzheimer’s Disease (in mother) 2.1 2.4 8.5 -2.9 -0.9 0.6 -1.5 0.4
Alzheimer’s Disease (in father) 0.4 0.5 1.6 -1.3 0.5 -0.1 -0.2 0.7
Alzheimer’s Disease (including proxy) 0.5 0.7 2.7 -1.6 0.6 -0.6 0.1 -0.1
Crohns Disease (2017) 2.7 5.9 8.5 -2.9 -1.4 2.1 -2.5 2.9
Irritable Bowel Disease (IBD) 0.8 1.9 3.4 -1.2 -1.1 1.3 -1.4 1.8
Ulcerative Colitis (UC) 0.1 0.2 1.0 1.0 -0.2 -0.0 -0.0 0.2
Major Depression (MDD) 2.9 3.5 5.9 0.0 1.7 -1.9 2.3 -2.4
Reaction Time 2.3 4.4 8.4 1.8 1.0 -2.5 1.7 -2.9
Verbal and Numeric Reasoning (VNR) 6.4 15.3 17.8 -4.1 -4.1 4.2 -4.0 3.0
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 2.4 3.2 7.1 0.8 1.2 -2.7 1.6 -2.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.5 3.7 6.5 -0.8 -0.8 2.3 -2.3 2.5
Bipolar Disorder (2011) 0.3 0.3 1.4 0.0 0.0 0.0 -1.2 0.0
Body Mass Index (BMI) (2010) 3.2 4.3 6.2 0.1 -2.4 2.0 -2.3 2.5
Coronary Artery Disease (CAD) 0.2 0.2 0.5 0.0 -0.5 0.7 -0.5 0.0
Crohns Disease (2012) 1.8 2.9 4.5 -2.1 -0.8 1.5 -1.7 2.1
Mean Putamen Volume 1.2 1.4 2.3 -1.3 -0.0 1.4 -0.8 1.5
Fasting Glucose 0.3 0.4 1.4 -0.3 -1.2 0.7 0.3 -0.0
HbA1C 0.9 1.0 4.3 2.1 0.6 -0.0 0.1 -0.6
HDL Cholesterol 1.2 2.0 8.0 0.3 -2.8 0.4 -1.1 0.6
LDL Cholesterol 0.4 0.6 2.1 0.9 -1.4 -0.3 -0.1 0.4
Lupus 0.4 0.6 1.2 1.1 -0.2 -1.1 0.6 -0.1
Neuroticism (2016) 0.3 0.4 1.5 -0.1 -1.2 -0.5 0.4 -0.4
Primary Biliary Cirrhosis 4.7 6.7 9.1 -0.6 -2.6 2.8 -3.0 3.0
Rheumatoid Arthritis 0.3 0.5 0.9 0.0 -0.3 -1.0 1.0 -0.6
Schizophrenia (2014) 11.1 24.6 45.2 0.0 -4.6 4.9 -5.7 6.7
Triglycerides 0.6 1.0 2.0 0.7 1.1 -1.1 1.4 -0.3
Type 2 Diabetes (T2D) (2012) 5.6 6.4 10.6 0.0 2.9 -3.0 3.2 -2.0
Ulcerative Colitis 0.0 0.1 0.3 0.0 0.5 -0.1 0.1 0.1
Blood Eosinophil Count 5.1 39.1 69.7 5.0 1.9 -8.3 7.5 -6.4
Blood Platelet Count 8.0 92.6 156.2 4.6 6.5 -12.5 11.7 -10.3
Blood Red Count 1.5 14.5 27.2 2.3 4.6 -2.8 3.3 -5.2
Blood White Count 0.2 1.6 4.7 0.5 -2.2 -1.6 0.4 0.4
Heel T-Score 9.8 77.6 102.0 6.1 8.0 -10.0 9.2 -10.1
BMI 1.0 5.8 25.1 5.0 1.1 -1.1 0.9 -0.8
Height 11.1 213.5 319.6 -8.9 -11.9 17.9 -15.3 17.1
Waist Hip Ratio (WHR) 9.0 40.5 75.5 -0.8 5.6 -7.7 8.7 -6.0
Systolic Blood Pressure 0.8 4.1 7.6 0.3 2.8 -1.9 1.6 -2.5
Smoking Status 0.4 0.8 1.8 -1.4 0.4 -0.6 1.3 -0.4
Allergy or Eczema 8.4 22.1 29.4 4.1 3.8 -5.4 5.3 -4.7
Cardiovascular Disease 0.8 2.6 4.4 1.8 -0.7 -1.7 1.3 -2.1
Hypothyroidism (self reported) 3.0 6.9 16.4 0.5 -4.0 2.7 -3.0 1.2
Respiratory disease 3.5 7.8 14.5 0.7 2.4 -3.8 3.3 -2.7
Type 2 Diabetes (T2D) (2018) 3.8 7.0 12.3 1.9 1.3 -3.1 3.5 -2.9
Lung FEV1/FVC ratio 1.4 7.0 9.1 2.3 2.8 -2.6 3.0 -2.5
Lung FVC 4.4 22.4 38.9 1.9 6.2 -4.6 5.2 -4.6
Neuroticism 0.8 2.0 3.4 1.4 -0.3 -1.8 1.6 -1.5
Chronotype (morning person) 0.7 1.5 3.2 -0.5 -1.5 1.8 -1.0 1.1
Hair Pigment 0.9 27.0 42.1 2.8 4.8 -6.5 6.0 -5.1
Tanning 0.1 1.5 2.9 -0.1 -0.5 1.5 -1.4 1.7
Hand grip strength (left) 0.4 1.2 4.0 0.9 2.0 0.8 0.0 0.6
Number of treatments/medications taken 1.5 2.8 5.2 1.8 -0.3 -2.3 1.9 -1.2
Average weekly spirits intake 2.5 3.1 6.4 2.5 1.4 -2.1 1.4 -1.0
Sensitivity / hurt feelings 0.5 0.8 1.5 1.2 0.4 -0.7 0.9 -1.1
Frequency of depressed mood in last 2 weeks 0.9 1.2 3.0 0.2 -0.6 -1.3 1.7 -1.1
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.5 0.6 0.2 0.3 0.2
Relative age of first facial hair 2.2 4.6 6.4 1.6 1.8 -2.5 2.5 -2.2
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 6.0 0.3 -2.4 0.8 -1.3 1.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.5 1.2 0.7 1.2 -0.4 -0.2
Ever had hysterectomy (womb removed) 6.0 6.7 9.1 2.2 2.0 -2.8 3.0 -2.9
Systolic blood pressure, automated reading 1.7 4.9 8.1 1.3 2.8 -2.2 2.3 -2.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.3 -0.6 0.9 -1.1 0.7 -1.2
Angina 1.0 1.3 3.4 -0.9 -1.9 1.0 -0.6 0.9
Medication for hormone replacement therapy 1.0 1.1 4.3 2.1 0.4 -0.5 0.2 -1.0
Vitamin and mineral supplements 1.4 1.9 3.1 -1.1 -1.3 1.5 -1.8 1.2
Supplements: Zinc 1.6 1.8 3.3 -1.6 -1.3 1.0 -0.4 1.8
Medication: Co-codamol 2.1 2.4 3.8 2.0 0.2 -1.7 1.9 -1.4
Medication: Metformin 4.1 5.9 10.6 1.9 0.9 -3.1 3.2 -2.2
Diabetes (father) 2.7 3.3 5.0 1.7 2.1 -1.8 1.1 -2.2
Diabetes (mother) 0.7 0.8 1.8 1.0 0.4 -1.0 1.3 -0.4
Severe depression (siblings) 1.3 1.4 1.9 -0.9 -1.2 1.0 -1.4 1.4
Pack years adult smoking proportion 0.4 0.7 1.7 -0.1 0.0 -0.9 1.0 -1.3
Impedance of leg (right) 1.3 6.1 10.7 0.1 2.1 -2.9 2.7 -3.3
Leg fat-free mass (left) 4.9 26.1 42.0 0.3 -4.4 6.5 -5.8 5.9
Trunk fat percentage 1.4 5.5 25.1 5.0 0.2 -0.9 0.5 -1.1
Hand grip strength (right) 0.3 0.8 1.3 0.8 1.2 1.1 -0.5 0.6
Townsend deprivation index at recruitment 0.4 0.6 1.5 -0.8 0.2 -0.7 0.8 -1.2
Current tobacco smoking 1.2 1.9 3.7 0.0 0.9 -1.4 1.9 -1.7
Average weekly fortified wine intake 0.1 0.1 0.2 0.0 -0.1 0.2 -0.3 0.4
Maternal smoking around birth 1.9 2.7 4.0 -1.0 1.9 -2.0 1.9 -1.0
Fed-up feelings 4.6 8.3 13.0 2.1 1.9 -3.6 3.5 -2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.5 1.3 0.2 -2.1 2.1 -0.2
Relative age voice broke 2.3 3.5 5.2 1.5 2.3 -1.6 1.8 -2.0
Taking other prescription medications 1.3 1.9 3.7 1.9 -0.1 -1.7 1.4 -1.1
Age when periods started (menarche) 0.2 0.6 1.6 -1.2 -0.1 -0.6 0.5 -0.8
Bilateral oophorectomy (both ovaries removed) 6.3 7.2 10.8 2.3 2.1 -3.0 3.3 -2.6
Heel bone mineral density (BMD) T-score, automated (left) 4.0 9.0 15.8 2.3 2.0 -4.0 3.0 -3.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.3 -0.3 -0.9 0.2 -1.2 1.0
Qualifications: CSEs or equivalent 2.2 2.9 4.2 1.3 1.7 -1.8 1.6 -2.1
Serious illness, injury or assault to yourself 1.2 1.4 2.9 0.2 -0.9 1.5 -1.7 1.1
High blood pressure 1.7 4.7 9.1 3.0 0.5 -2.1 1.9 -2.5
Hayfever, allergic rhinitis or eczema 8.4 18.2 21.3 4.2 3.7 -4.5 4.6 -4.2
Multivitamins +/- minerals 0.9 1.2 2.8 0.6 1.7 -1.2 1.2 -0.4
Stomach or abdominal pain in last month 0.8 1.0 2.4 1.5 -0.0 -0.9 0.6 -1.1
Supplements: Glucosamine 4.4 5.8 7.7 2.0 2.2 -2.4 2.8 -2.6
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 5.6 2.4 1.5 -1.7 1.8 -1.2
Medication: Atenolol 0.5 0.6 2.3 -1.5 -0.8 0.2 -0.0 0.2
Medication: Levothyroxine sodium 3.6 6.1 14.5 0.1 -3.8 2.0 -2.7 2.1
Sitting height 20.0 142.1 196.0 -6.7 -10.1 14.0 -13.2 13.9
Chronic bronchitis/emphysema (father) 0.4 0.5 1.3 0.3 0.2 -1.2 0.8 -0.5
High blood pressure (mother) 0.2 0.2 0.6 0.8 -0.4 -0.2 0.1 0.5
Body mass index (BMI) 1.5 6.6 27.2 5.2 0.9 -1.3 1.2 -1.3
Impedance of leg (left) 2.0 9.7 14.6 0.4 2.8 -3.8 3.4 -3.8
Leg predicted mass (left) 4.9 26.0 41.8 0.2 -4.4 6.5 -5.8 5.9
Trunk fat mass 1.1 4.9 19.2 4.4 -1.1 1.2 -1.2 1.0
Waist circumference 0.6 2.2 7.7 2.8 0.5 -1.1 1.4 -0.3
Number of incorrect matches in round 0.7 1.2 2.6 -0.4 1.6 -1.1 1.3 -0.0
Past tobacco smoking 2.7 4.9 9.4 3.1 1.3 -2.1 1.6 -2.5
Alcohol usually taken with meals 2.3 3.7 6.1 -0.3 -1.8 2.5 -2.0 2.3
Nervous feelings 0.3 0.6 2.4 -0.4 -1.5 -0.0 -0.4 0.2
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.2 5.2 1.4 -0.2 -2.0 2.3 -2.2
Hearing difficulty/problems with background noise 4.8 7.6 12.3 -2.3 -2.5 2.6 -2.7 3.5
Hair/balding pattern: Pattern 2 1.1 1.4 2.8 -0.5 1.1 -1.3 1.0 -1.7
Had menopause 7.1 8.8 13.8 -1.0 -2.6 3.7 -3.1 3.6
Had other major operations 0.9 1.1 3.8 -0.1 -1.9 0.3 -0.9 1.0
Forced vital capacity (FVC) 0.3 1.2 1.6 1.3 1.1 1.3 -0.9 0.8
Heel bone mineral density (BMD) T-score, automated (right) 3.2 7.3 13.0 1.6 1.8 -3.6 2.8 -3.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 -0.2 -0.1 -1.0 0.9 0.3
Qualifications: None of the above 12.1 25.8 43.4 1.1 4.5 -6.2 6.6 -5.0
Financial difficulties in last 2 years 3.4 4.6 9.1 3.0 1.4 -1.3 1.5 -2.8
Mouth/teeth dental problems 0.5 0.8 2.1 1.5 1.2 -0.1 -0.3 -0.6
Heart attack 0.4 0.5 0.9 -0.7 0.6 -0.9 1.0 -0.0
Allergy 11.6 26.7 33.9 -3.8 -5.0 5.8 -5.6 5.5
Pain all over the body in last month 0.7 0.7 1.8 0.0 0.6 -1.0 1.3 -0.8
Diabetes (self-reported) 2.1 3.3 5.9 1.5 0.8 -2.4 2.4 -1.5
Hayfever/allergic rhinitis (self-reported) 4.1 5.5 11.0 3.3 1.7 -2.6 2.0 -1.6
Medication: Ramipril 0.4 0.5 1.1 0.5 0.0 -0.9 0.6 -1.0
Medication: Simvastatin 0.8 1.2 1.8 1.1 -1.3 -1.0 1.2 -0.5
Fluid intelligence score 8.1 16.9 22.4 -2.4 -4.2 4.7 -4.6 4.2
Illnesses of siblings 1.3 1.8 2.3 -1.2 -1.3 1.4 -1.5 1.3
Neuroticism score 1.6 3.3 5.7 1.3 0.0 -2.4 2.1 -2.1
Weight 2.7 13.4 18.8 2.4 -3.1 4.3 -3.9 4.1
Impedance of arm (right) 0.0 0.2 0.5 -0.0 -0.5 0.0 -0.2 -0.7
Arm fat percentage (right) 2.4 9.4 36.9 6.1 0.9 -1.7 1.5 -2.1
Trunk fat-free mass 7.1 40.5 65.2 -1.7 -5.1 8.1 -7.1 7.6
Hip circumference 3.1 13.5 20.5 2.2 -2.8 4.2 -4.5 4.0
Time employed in main current job 0.5 0.6 1.4 -0.7 -0.9 -0.2 -0.1 1.2
Alcohol intake versus 10 years previously 5.9 8.9 14.5 2.1 2.6 -3.3 2.8 -3.8
Father’s age at death 6.5 8.8 13.2 -2.8 -1.1 3.6 -3.3 3.3
Worrier / anxious feelings 1.5 2.8 4.6 1.1 0.8 -1.9 2.1 -1.9
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.0 1.2 -1.4 -1.7 1.4 -0.7
Falls in the last year 1.0 1.3 3.8 0.5 -1.9 1.2 -1.0 0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.5 0.4 0.2 -0.1 -0.2
Number of live births 0.3 0.5 1.0 -0.3 -0.7 1.0 -0.8 0.5
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 5.0 2.2 2.1 0.2 0.1 -0.2
Pulse rate 0.9 1.6 7.2 2.7 0.3 0.1 0.3 0.7
Happiness 0.8 0.9 3.0 -0.8 -1.7 0.3 -0.9 0.5
Noisy workplace 4.7 5.8 10.7 0.1 2.1 -3.0 3.3 -2.2
Qualifications: A levels/AS levels or equivalent 17.4 38.6 52.4 -2.9 -6.3 7.0 -7.2 6.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 -0.0 -1.0 0.1 -0.7 0.5
Mouth/teeth dental problems: Dentures 0.1 0.1 0.3 -0.1 -0.4 -0.1 0.6 -0.2
Asthma 3.3 6.5 12.2 0.9 2.2 -3.5 3.1 -2.3
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 4.7 1.3 0.2 -2.2 2.2 -1.5
Medication: Cholesterol lowering 0.5 0.8 2.7 1.0 -1.6 -0.2 0.2 0.5
Depression (self-reported) 2.5 3.0 6.5 0.8 1.3 -2.1 2.5 -1.3
Medication: Lansoprazole 5.0 5.7 8.8 1.9 1.6 -2.7 3.0 -2.5
Prospective memory result 1.0 1.2 2.5 1.0 1.6 -0.7 1.2 -0.7
Lung cancer (father) 0.4 0.5 1.1 -1.1 -0.5 0.1 0.3 1.1
Illnesses of mother 0.3 0.4 1.1 -0.2 0.5 -0.6 1.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.9 1.7 1.7 0.3 0.1 0.1
Pulse wave Arterial Stiffness index 2.3 2.6 5.3 -0.1 -1.9 1.5 -1.4 2.3
Impedance of arm (left) 0.1 0.4 1.3 -0.3 -0.6 -0.1 -0.1 -1.1
Arm fat mass (right) 1.2 4.8 22.6 4.8 -0.5 0.7 -0.7 0.4
Trunk predicted mass 7.1 40.8 65.6 -1.7 -5.1 8.1 -7.2 7.6
Standing height 10.1 100.2 148.8 -5.7 -8.2 12.2 -11.0 11.5
Length of working week for main job 1.9 2.1 4.3 1.5 1.7 -0.9 0.8 -2.1
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.3 -0.1 0.4 0.6 0.4
Breastfed as a baby 10.5 13.0 16.7 -3.5 -2.7 3.7 -3.8 4.1
Tense / ‘highly strung’ 2.5 4.2 7.1 0.4 1.6 -2.7 2.6 -2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 3.3 5.1 8.0 0.4 1.8 -2.8 2.8 -2.5
Hair/balding pattern: Pattern 4 1.1 2.5 4.5 -1.0 -0.9 1.7 -1.9 2.1
Birth weight of first child 0.1 0.2 1.0 -0.1 -1.0 0.3 -0.1 0.0
Peak expiratory flow (PEF) 0.4 0.8 1.7 0.7 -0.5 1.0 -0.9 1.3
Pulse wave reflection index 0.2 0.3 0.7 0.2 -0.2 -0.9 0.5 -0.5
Ever highly irritable/argumentative for 2 days 5.6 6.7 12.0 1.9 2.1 -2.8 3.5 -2.4
Loud music exposure frequency 0.4 0.4 1.0 -0.4 -1.0 -0.7 0.5 -0.1
Qualifications: O levels/GCSEs or equivalent 16.1 25.6 43.5 -3.1 -4.0 6.1 -6.6 4.7
Mouth/teeth dental problems: Bleeding gums 2.2 2.9 3.7 -0.7 -1.8 1.9 -1.9 1.9
Blood clot in the leg (DVT) 5.7 7.3 11.6 0.6 3.2 -2.8 2.7 -3.4
Medication: Paracetamol 4.8 8.0 12.1 2.6 1.2 -3.5 3.0 -3.3
Headache pain in last month 0.5 0.9 4.1 -0.1 -2.0 -0.4 0.2 -0.3
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.0 -1.0 0.0 2.0 -1.5 0.8
Glaucoma (self-reported) 5.1 6.0 10.8 0.2 2.6 -2.3 3.3 -2.6
Gout (self-reported) 0.5 0.6 1.9 1.4 -0.6 0.2 -0.7 -0.6
Hypothyroidism/myxoedema (self-reported) 3.8 7.4 20.2 0.2 -4.5 2.4 -2.9 1.6
Medication: Amlodipine 0.3 0.4 1.3 -0.3 -1.1 0.2 0.5 0.5
Medication: Ventolin 100micrograms inhaler 3.2 4.1 8.3 0.5 2.4 -1.7 1.8 -2.9
Birth weight 1.3 2.9 6.1 -1.5 -1.4 2.5 -1.5 1.4
Chronic bronchitis/emphysema (mother) 0.6 0.8 1.4 -0.2 0.4 -0.9 1.2 -1.1
High blood pressure (siblings) 0.2 0.2 0.3 0.5 0.6 -0.1 0.6 -0.6
Forced vital capacity (FVC), Best measure 0.3 1.2 2.2 0.7 0.8 1.5 -1.2 1.3
Body fat percentage 2.2 8.8 34.2 5.8 0.9 -1.8 1.5 -2.0
Leg fat percentage (right) 3.9 14.2 40.5 6.4 2.0 -3.1 2.9 -2.9
Arm fat-free mass (right) 4.9 25.1 40.9 -0.6 -4.0 6.4 -5.7 6.0
Exposure to tobacco smoke outside home 0.7 1.0 1.7 0.8 0.7 -1.0 1.3 -1.0
Comparative body size at age 10 1.4 3.7 7.6 -0.4 -2.8 2.5 -1.9 1.1
Number of full brothers 0.4 0.5 0.9 -0.9 0.1 -1.0 0.3 -0.7
Worry too long after embarrassment 0.2 0.3 0.8 0.9 -0.9 0.1 -0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.1 1.8 0.4 -1.2 1.1 -1.0
Wheeze or whistling in the chest in last year 1.6 2.8 5.1 0.2 0.8 -2.1 2.0 -2.3
Number of children fathered 1.9 2.1 5.8 -0.7 -0.1 1.5 -1.4 2.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 0.7 -0.3 0.7 -0.3 0.3
Age at first live birth 2.4 4.3 8.5 -1.3 -1.1 2.4 -2.2 2.9
Pulse wave peak to peak time 0.6 0.7 1.5 -0.4 1.2 -0.4 0.4 -1.2
Health satisfaction 0.3 0.4 0.8 0.4 -0.2 -0.8 0.7 -0.9
Shortness of breath walking on level ground 0.3 0.3 0.7 0.6 -0.4 -0.8 0.5 -0.5
Qualifications: College or University degree 9.7 30.5 42.1 -2.4 -5.4 5.9 -6.4 6.5
Eye problems/disorders: None of the above 0.3 0.3 0.6 0.0 0.4 0.8 -0.8 0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.9 -1.4 -0.1 0.5 -0.7 -0.2
Emphysema/chronic bronchitis 0.8 0.9 2.2 -0.8 1.5 -0.4 0.7 -1.1
Medication for pain relief, constipation, heartburn 7.1 12.1 20.0 -2.5 -1.3 4.5 -4.3 3.7
Neck or shoulder pain in last month 0.8 1.1 1.4 0.2 -1.2 -1.2 1.2 -1.1
Medication: Blood pressure 0.8 1.3 3.2 0.7 0.2 -1.8 1.2 -1.2
Angina (self-reported) 1.3 1.7 4.6 -1.0 -2.2 1.0 -0.8 1.2
Migraine (self-reported) 0.9 1.2 3.2 1.8 -0.2 -0.5 0.5 -1.4
Medication: Ibuprofen 0.3 0.4 0.7 0.6 -0.8 -0.8 0.6 -0.1
Medication: Allopurinol 0.1 0.1 0.3 -0.0 -0.5 0.2 -0.6 -0.3
Medication: Omeprazole 2.2 2.7 5.2 1.8 -0.4 -2.3 1.9 -1.1
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.5 0.1 -0.4 0.3 -0.5
Mean time to correctly identify matches 0.5 1.0 2.7 0.2 0.1 -1.6 1.0 -1.2
Heart disease (mother) 2.5 3.1 5.2 0.5 -1.4 2.0 -2.3 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.5 0.3 -0.1 -0.5 -0.0
Whole body fat mass 1.2 4.8 23.1 4.8 -0.5 0.5 -0.6 0.3
Leg fat mass (right) 1.6 6.0 29.3 5.4 0.4 -0.5 0.6 -0.5
Arm predicted mass (right) 4.7 24.0 38.6 -0.6 -3.9 6.2 -5.5 5.9
Pulse rate, automated reading 0.9 3.0 11.5 3.4 0.5 -1.3 1.3 -0.1
Alcohol intake frequency. 6.5 15.2 20.7 2.7 2.9 -4.4 4.5 -4.5
Comparative height size at age 10 12.8 70.3 102.0 -4.1 -7.9 10.1 -8.9 9.6
Number of full sisters 0.1 0.2 0.6 -0.8 0.4 0.1 0.2 -0.1
Suffer from ‘nerves’ 0.9 1.4 3.2 1.5 -0.2 -0.8 1.0 -1.8
Overall health rating 1.4 2.9 5.3 1.4 0.0 -2.1 1.8 -2.3
Chest pain or discomfort 0.7 1.0 3.4 -1.9 -0.8 0.8 -0.4 0.4
Had major operations 0.6 0.7 1.4 0.1 -0.9 0.8 -1.2 0.9
Age at last live birth 3.1 4.6 7.4 -1.5 -0.9 2.4 -2.5 2.7
Family relationship satisfaction 0.1 0.1 0.3 -0.5 -0.3 -0.1 -0.3 -0.3
Leg pain on walking 1.7 2.2 3.3 1.1 1.2 -1.5 1.7 -1.8
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 5.3 2.3 0.5 -1.4 1.1 -1.8
Commuting to job workplace: Car/motor vehicle 3.9 4.5 6.7 2.0 2.6 -1.8 1.6 -2.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.7 -1.2 -0.3 0.7 -0.6 1.3
Medication: Aspirin 0.2 0.3 0.8 0.2 0.1 -0.5 0.9 -0.5
Supplements: Vitamin C 1.4 1.6 3.0 0.8 0.7 -1.4 1.7 -1.4
Knee pain experienced in last month 6.0 9.3 13.6 2.9 2.2 -3.3 3.7 -2.9
Hypertension (Self-reported) 1.9 5.3 10.2 3.2 0.3 -2.3 2.1 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.5 4.1 5.6 1.3 1.7 -2.1 2.4 -2.3
Illnesses of father: Heart disease 1.3 1.9 4.9 0.4 -0.4 1.5 -1.3 2.2
Illnesses of siblings: Diabetes 3.5 4.3 7.5 0.5 2.7 -2.1 2.6 -1.6
Smoking status: Previous 2.2 3.3 8.5 -2.9 -0.2 1.5 -1.3 2.1
Forced expiratory volume in 1-second (FEV1), predicted 3.1 6.4 10.1 -1.9 -1.8 3.1 -3.2 2.3
Whole body fat-free mass 6.1 35.0 55.8 -0.8 -4.9 7.5 -6.7 7.0
Leg fat-free mass (right) 5.2 27.7 42.9 -0.1 -4.5 6.5 -6.0 6.2
Arm fat percentage (left) 2.4 9.7 37.6 6.1 0.8 -1.8 1.5 -2.2
Average weekly red wine intake 9.6 14.2 20.7 -1.4 -4.0 4.4 -3.6 4.5
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.5 -0.0 0.9 -1.1 0.5 -1.2
Mood swings 2.4 4.4 8.5 0.0 0.2 -2.9 2.6 -2.5
Loneliness, isolation 1.2 1.7 3.0 1.4 -0.1 -1.7 1.3 -1.3
Long-standing illness, disability or infirmity 4.6 7.1 9.5 3.1 1.4 -3.0 2.9 -2.6
Ever had bowel cancer screening 1.3 1.5 2.1 -1.3 -1.2 1.1 -1.1 1.5
Diabetes diagnosed by doctor 3.0 5.0 7.7 2.2 1.1 -2.5 2.8 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.6 0.2 -0.5 0.7 -1.3 1.3
Friendships satisfaction 1.0 1.2 2.9 -0.7 -1.7 0.8 -1.2 0.9
Qualifications: nursing, teaching 12.2 19.0 24.4 -2.3 -4.5 4.9 -4.7 4.7
Commuting to job workplace: Walk 0.5 0.5 0.7 0.8 0.6 -0.8 0.6 -0.5
Eye problems/disorders: Cataract 0.2 0.2 0.7 0.3 -0.8 0.2 -0.5 0.2
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 7.1 -0.5 0.6 -2.7 2.4 -1.6
Medication for cholesterol 1.7 2.6 5.5 -2.4 -0.0 1.6 -1.8 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.1 0.6 -0.3 -1.1 1.0 -1.0
Back pain experienced in last month 5.5 8.0 12.5 2.0 2.6 -3.5 3.1 -2.6
Mineral and other dietary supplements 0.7 1.0 2.1 0.8 -0.8 1.2 -1.5 0.2
Breast cancer (self-reported) 4.5 5.4 7.8 -2.3 -2.2 2.3 -2.8 1.9
Asthma (self-reported) 3.9 7.8 14.7 1.1 2.2 -3.8 3.4 -2.6
Osteoporosis (self-reported) 0.3 0.3 1.3 0.6 -0.1 0.1 0.1 -1.1
Osteoarthritis (self-reported) 4.2 5.5 8.4 0.8 2.5 -2.9 2.7 -2.2
Medication: Aspirin 0.1 0.1 0.3 -0.5 -0.4 0.1 0.4 0.3
Medication: Gliclazide 1.5 1.7 3.2 0.0 1.0 -1.8 1.8 -1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.6 -1.1 -1.2 0.6 -0.0 0.2
Smoking status: Current 1.1 1.7 3.6 -0.0 0.8 -1.3 1.9 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.8 5.9 13.2 2.4 3.6 -1.9 2.2 -1.4
Whole body water mass 6.2 35.5 56.8 -0.8 -4.9 7.5 -6.8 7.1
Leg predicted mass (right) 5.2 27.8 42.8 -0.2 -4.6 6.5 -6.0 6.2
Arm fat mass (left) 1.1 4.6 21.4 4.6 -0.6 0.7 -0.7 0.3
Number of self-reported non-cancer illnesses 2.8 4.9 7.4 2.3 0.3 -2.7 2.5 -2.4
Average weekly champagne plus white wine intake 1.4 1.9 4.7 -1.0 0.4 1.5 -1.3 2.2
Miserableness 1.5 2.6 6.4 0.6 -0.0 -2.0 1.6 -2.5
Guilty feelings 0.5 0.7 2.4 0.4 -1.5 -0.9 0.2 0.4
Wears glasses or contact lenses 3.5 4.0 4.8 -1.8 -2.0 2.2 -2.0 2.1
Ever taken oral contraceptive pill 2.2 2.5 4.5 -1.1 -0.8 1.4 -2.0 2.1
Hearing aid user 0.1 0.1 0.4 -0.4 0.2 -0.2 0.6 0.2
Mother’s age at death 1.3 1.7 2.9 -1.5 -0.5 1.4 -1.0 1.7
Financial situation satisfaction 3.6 4.5 7.1 0.6 1.9 -2.4 2.7 -2.3
Tinnitus: Yes, now most or all of the time 3.8 4.4 5.7 1.8 1.9 -2.2 2.4 -2.2
Commuting to job workplace: Public transport 2.3 2.7 6.3 -0.5 -2.5 1.6 -1.3 1.5
Eye problems/disorders: Glaucoma 1.1 1.3 2.7 -0.1 1.4 -0.9 1.7 -1.1
Medication: Blood pressure 1.6 3.1 5.8 1.7 0.7 -1.9 2.4 -1.7
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.4 1.2 -1.2 0.5 -0.3 0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.2 -1.2 1.3 -1.3 1.5 -0.0
High cholesterol (Self-reported) 1.1 2.0 3.9 0.5 -1.4 -2.0 1.8 -0.9
Medication: Bendroflumethiazide 1.4 2.2 4.4 1.5 0.3 -1.5 1.4 -2.1
Medication: Paracetamol 2.4 3.7 5.4 2.1 0.5 -2.3 1.8 -2.3
Medication: Lisinopril 2.3 3.0 5.2 -0.2 1.1 -2.3 2.3 -1.8
Medication: Atorvastatin 1.5 1.9 4.2 -1.7 -2.1 0.3 -0.7 1.4
Illnesses of father: High blood pressure 0.3 0.4 0.6 0.4 0.6 -0.7 0.4 -0.8
Alcohol drinker status: Never 7.5 8.9 11.1 2.7 3.2 -2.9 2.8 -3.3
Ever smoked 5.1 9.0 11.2 -3.4 -2.3 3.1 -2.8 3.3
Basal metabolic rate 5.3 29.5 47.5 -0.1 -4.5 6.9 -6.2 6.4
Leg fat percentage (left) 4.5 16.4 41.6 6.5 2.5 -3.6 3.4 -3.1
Arm fat-free mass (left) 5.0 25.4 41.3 -0.5 -3.8 6.4 -5.7 6.2
Number of operations (self-reported) 0.3 0.5 0.8 0.7 -0.6 -0.9 0.3 -0.9
Average weekly beer plus cider intake 0.3 0.4 1.5 0.2 1.2 -0.0 -0.1 -0.8
Irritability 1.2 2.0 5.1 0.3 0.2 -1.9 1.1 -2.3
Risk taking 0.9 1.3 3.8 2.0 0.7 -0.2 0.1 -1.4
Ever had prostate specific antigen (PSA) test 2.5 2.8 5.9 -0.2 -1.3 2.0 -1.6 2.4
Fractured/broken bones in last 5 years 4.1 5.3 7.2 -1.7 -2.2 2.5 -2.3 2.7
Age started oral contraceptive pill 3.0 3.7 5.0 -1.6 -1.8 2.2 -1.8 2.2
Diastolic blood pressure, automated reading 13.4 41.4 52.6 6.3 4.5 -7.0 6.7 -7.2
Ever depressed for a whole week 0.1 0.1 0.2 -0.3 -0.4 -0.4 0.2 0.1
Unable to work because of sickness or disability 0.6 0.8 1.5 0.5 -0.5 -1.0 0.9 -1.2
Commuting to job workplace: Cycle 3.6 4.4 15.2 -3.9 -0.6 1.2 -1.3 1.8
Myopia 2.5 3.6 5.8 -1.6 -2.0 1.7 -1.6 2.4
Vascular/heart problems diagnosed by doctor 1.5 4.1 6.3 -2.4 -0.5 2.1 -1.9 2.5
Cholesterol lowering medication 1.3 1.9 3.6 0.6 -1.4 -1.9 1.8 -0.6
Medication: Omeprazole (e.g. Zanprol) 2.6 3.2 7.3 1.3 0.5 -2.7 2.3 -1.1
Pain experienced in last month 3.8 6.4 8.6 -2.1 -1.5 2.9 -2.9 2.9
Supplements: Calcium 6.5 7.2 11.1 -3.3 -2.7 2.3 -2.1 2.7
Basal cell carcinoma (self-reported) 0.8 1.0 2.6 -1.6 -0.1 0.9 -0.5 1.1
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.7 -0.4 0.8 -1.1 1.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 6.6 8.5 12.0 0.8 3.3 -3.1 3.0 -3.5
Heart disease (siblings) 3.2 3.9 5.3 1.7 1.4 -2.1 2.2 -2.3
Alcohol drinker status: Previous 0.4 0.5 1.1 0.4 -0.8 -0.6 1.0 0.3
Pack years of smoking 0.2 0.3 0.7 -0.4 -0.3 -0.6 0.6 -0.9
Impedance of whole body 0.7 3.5 7.0 -0.0 1.3 -2.3 1.9 -2.6
Leg fat mass (left) 1.6 6.4 29.8 5.5 0.7 -0.7 0.8 -0.6
Arm predicted mass (left) 4.8 24.4 40.3 -0.2 -3.8 6.3 -5.7 5.9