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chr22:41,641,984-43,232,818

Best TWAS P=5.21e-09 · Best GWAS P=7.79e-09 conditioned to 0.0135

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM109B	0.06	0.02	blup	337	0.03	7.4e-05	-4.2	5.5	4.4e-08	-0.57	0.19	0.81	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NAGA	0.09	0.09	blup	336	0.13	1.2e-15	-4.2	5.8	5.2e-09	-0.68	0.35	0.65	TRUE
3	GTEx	Adipose Subcutaneous	FAM109B	0.06	0.04	lasso	3	0.03	1.1e-03	-5.2	5.2	2.3e-07	-0.64	0.10	0.84	FALSE
4	GTEx	Adipose Visceral Omentum	SMDT1	0.48	0.57	lasso	5	0.57	1.5e-35	-5.2	5.1	3.0e-07	-0.64	0.10	0.90	FALSE
5	GTEx	Adrenal Gland	SMDT1	0.28	0.22	lasso	2	0.20	1.3e-07	-5.0	5.1	2.9e-07	-0.65	0.13	0.85	FALSE
6	GTEx	Artery Aorta	SMDT1	0.37	0.49	lasso	7	0.48	1.9e-29	-5.1	5.2	2.0e-07	-0.64	0.11	0.89	FALSE
7	GTEx	Brain Cortex	FAM109B	0.13	0.10	enet	14	0.09	2.2e-03	-5.4	5.5	4.2e-08	-0.62	0.08	0.73	FALSE
8	GTEx	Brain Hypothalamus	CENPM	0.54	0.28	lasso	3	0.26	8.5e-07	-4.6	-5.4	6.2e-08	0.76	0.06	0.76	FALSE
9	GTEx	Breast Mammary Tissue	SMDT1	0.49	0.52	lasso	5	0.52	7.1e-31	-5.1	5.2	2.4e-07	-0.64	0.11	0.89	FALSE
10	GTEx	Breast Mammary Tissue (Female)	SMDT1	0.50	0.38	lasso	5	0.36	1.1e-11	-5.1	5.1	3.0e-07	-0.63	0.11	0.89	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	SMDT1	0.42	0.48	lasso	3	0.48	1.2e-17	-5.1	5.1	2.6e-07	-0.64	0.11	0.89	FALSE
12	GTEx	Cells Transformed fibroblasts	FAM109B	0.17	0.07	lasso	6	0.07	4.3e-06	-5.4	-5.4	7.9e-08	0.65	0.06	0.92	FALSE
13	GTEx	Cells Transformed fibroblasts	SMDT1	0.25	0.32	lasso	3	0.32	2.7e-24	-5.1	5.2	2.5e-07	-0.64	0.11	0.89	FALSE
14	GTEx	Esophagus Muscularis	FAM109B	0.15	0.08	lasso	4	0.06	1.8e-04	-5.2	5.2	2.0e-07	-0.66	0.10	0.85	FALSE
15	GTEx	Heart Atrial Appendage	RP4-669P10.16	0.08	0.11	lasso	8	0.11	1.3e-05	-5.3	5.2	1.6e-07	-0.64	0.09	0.89	FALSE
16	GTEx	Lung	CYP2D7P1	0.20	0.00	lasso	8	0.00	4.2e-01	4.1	5.6	2.0e-08	-0.70	0.03	0.54	FALSE
17	GTEx	Muscle Skeletal	SMDT1	0.17	0.26	enet	17	0.28	1.3e-27	-5.2	5.4	5.1e-08	-0.71	0.10	0.90	FALSE
18	GTEx	Nerve Tibial	RP4-669P10.16	0.06	0.08	lasso	2	0.05	1.2e-04	-5.3	5.3	1.1e-07	-0.63	0.07	0.92	FALSE
19	GTEx	Ovary	RP4-669P10.16	0.24	0.34	lasso	6	0.30	4.0e-08	-5.2	5.1	2.9e-07	-0.65	0.10	0.89	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	SMDT1	0.46	0.54	lasso	8	0.53	7.4e-34	-5.1	5.1	2.9e-07	-0.64	0.11	0.89	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	NAGA	0.13	0.06	lasso	3	0.07	1.4e-04	4.8	5.4	6.7e-08	-0.34	0.15	0.31	FALSE
22	GTEx	Spleen	SMDT1	0.71	0.74	lasso	2	0.73	1.1e-26	-5.1	5.1	2.8e-07	-0.64	0.11	0.89	FALSE
23	GTEx	Stomach	SMDT1	0.47	0.52	enet	12	0.51	3.3e-28	-5.2	5.1	2.9e-07	-0.64	0.10	0.90	FALSE
24	GTEx	Stomach	CYP2D7P1	0.22	0.10	lasso	14	0.07	2.7e-04	-5.1	5.7	1.1e-08	-0.60	0.10	0.82	FALSE
25	GTEx	Stomach	NDUFA6-AS1	0.20	0.19	lasso	1	0.17	1.9e-08	-5.2	5.2	1.9e-07	-0.64	0.10	0.90	FALSE
26	GTEx	Testis	RP4-669P10.16	0.35	0.33	enet	28	0.36	8.9e-17	-5.1	5.5	4.0e-08	-0.63	0.10	0.90	FALSE
27	GTEx	Thyroid	FAM109B	0.07	0.06	lasso	9	0.05	2.1e-04	-5.2	5.1	2.8e-07	-0.64	0.10	0.89	FALSE
28	GTEx	Thyroid	SMDT1	0.36	0.44	lasso	4	0.44	7.8e-37	-5.1	5.1	3.0e-07	-0.64	0.11	0.88	FALSE
29	GTEx	Thyroid	RP4-669P10.16	0.17	0.10	enet	16	0.08	5.3e-07	-5.1	5.3	1.4e-07	-0.62	0.09	0.91	FALSE
30	GTEx	Thyroid	NDUFA6-AS1	0.21	0.16	enet	22	0.19	3.3e-14	-5.1	5.3	1.1e-07	-0.55	0.10	0.90	FALSE
31	GTEx	Vagina	CYP2D6	0.19	0.08	enet	14	0.08	6.8e-03	4.8	-5.4	7.6e-08	0.57	0.08	0.56	FALSE
32	NTR	Blood	C22orf32	0.09	0.18	lasso	3	0.18	2.7e-54	-5.2	5.2	2.5e-07	-0.63	0.13	0.87	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C22orf32	0.10	0.07	enet	10	0.10	3.6e-09	-5.1	5.5	3.3e-08	-0.54	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NAGA	0.04	0.07	enet	3	0.07	1.1e-06	-5.2	5.4	5.7e-08	-0.59	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SEPT3	0.03	0.01	blup	44	0.02	1.7e-02	4.8	5.4	5.1e-08	-0.70	0.03	0.39	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	NAGA	0.03	0.03	lasso	2	0.03	1.2e-07	4.7	5.4	8.4e-08	-0.54	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	C22orf32	0.14	0.07	lasso	4	0.07	3.1e-03	-5.3	5.3	1.2e-07	-0.63	0.00	0.76	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NAGA	0.01	0.00	blup	18	0.01	5.4e-02	-4.2	5.1	3.1e-07	-0.59	0.01	0.62	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C22orf32	0.10	0.10	lasso	4	0.11	8.4e-07	-5.1	5.3	1.2e-07	-0.64	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	C22orf32	0.16	0.18	enet	4	0.19	2.3e-21	-5.0	5.1	2.8e-07	-0.64	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	NAGA	0.02	0.00	blup	18	0.01	1.5e-02	-5.3	5.3	1.3e-07	-0.59	0.01	0.80	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C22orf32	0.11	0.13	lasso	4	0.12	1.5e-05	-5.3	5.3	1.2e-07	-0.63	0.00	0.98	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	C22orf32	0.22	0.30	lasso	3	0.29	8.8e-31	-5.2	5.2	2.5e-07	-0.63	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C22orf32	0.34	0.25	lasso	4	0.25	2.0e-09	-5.3	5.3	1.2e-07	-0.63	0.00	1.00	FALSE