TWAS hub - CENPM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.1510	0.0660	3.6e-03	0.001	NA	-0.004	NA	0.022	3.0e-01	NA	4.2e-01	NA	8.7e-02
2	GTEx	Brain Hypothalamus	0.5400	0.1260	1.5e-03	0.277	NA	0.153	NA	0.259	3.2e-07	NA	1.9e-04	NA	8.5e-07
3	GTEx	Brain Nucleus accumbens basal ganglia	0.3450	0.0960	4.7e-05	0.125	NA	0.209	NA	0.233	3.2e-04	NA	2.8e-06	NA	6.8e-07
4	GTEx	Skin Sun Exposed Lower leg	0.0460	0.0230	5.0e-03	-0.002	NA	0.016	NA	0.004	4.7e-01	NA	1.5e-02	NA	1.5e-01
5	GTEx	Testis	0.1250	0.0640	3.6e-03	0.186	NA	0.162	NA	0.160	1.2e-08	NA	1.1e-07	NA	1.4e-07
6	TCGA	Brain Lower Grade Glioma	0.0499	0.0262	5.3e-04	0.019	0.033	0.023	NA	0.025	2.5e-03	0.00011	1.1e-03	NA	6.9e-04
7	TCGA	Prostate Adenocarcinoma	0.0367	0.0203	5.1e-03	0.006	0.018	0.013	NA	0.021	6.7e-02	0.00460	1.3e-02	NA	2.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Schizophrenia (2014)	8.5	18.7	33.0	-4.4	-5.7	-5.3	-1.4	-4.5	-5.1	0.9
Alzheimer’s Disease (in father)	8.2	8.9	14.7	-3.5	-3.3	-2.4	-0.2	-3.8	-2.5	3.5
Schizophrenia (2018)	7.5	15.6	29.3	-3.9	-5.4	-5.0	-2.1	-3.8	-4.7	0.1
Number of full sisters	6.4	7.9	14.0	-3.3	-2.7	-3.7	-2.2	-3.2	-2.6	1.1
Bipolar Disorder or Schizophrenia	5.3	13.0	23.1	-3.5	-4.8	-4.2	-0.7	-3.7	-4.8	0.8
Age at First Birth	4.9	7.2	12.7	2.8	3.1	1.7	-0.6	3.6	2.4	-3.3
Current tobacco smoking	4.3	7.0	13.3	-3.4	-2.5	-3.0	-1.7	-3.6	-1.0	2.3
Number of children fathered	4.2	4.7	11.0	-2.0	-2.5	-1.4	0.5	-2.2	-2.2	3.3
Diabetes (mother)	4.1	5.3	10.6	-2.4	-2.8	-3.3	-1.5	-2.3	-2.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.4	7.5	-2.7	-2.2	-2.5	-0.5	-2.5	-1.7	1.7
Smoking status: Current	3.8	6.0	11.3	-3.1	-2.3	-2.6	-1.6	-3.4	-1.1	2.2
Chronotype (morning person)	3.7	8.5	16.8	3.5	2.8	2.8	1.2	3.4	1.1	-4.1
Alzheimer’s Disease (including proxy)	3.6	5.2	7.5	-2.4	-2.7	-2.3	-0.8	-2.6	-2.4	2.1
Supplements: Fish oil (including cod liver oil)	3.6	4.7	10.9	-1.7	-1.8	-1.9	1.9	-2.3	-1.7	3.3
Fed-up feelings	3.5	6.4	10.9	3.3	2.5	2.7	2.0	3.3	1.7	-1.7
Supplements: Calcium	3.5	3.9	7.1	2.7	1.8	2.0	1.3	2.4	2.0	-1.1
Maternal smoking around birth	3.4	5.0	8.6	-2.7	-2.2	-2.3	-0.7	-2.9	-1.8	2.3
Stomach or abdominal pain in last month	3.4	4.3	7.7	-2.2	-2.4	-1.9	0.4	-2.3	-2.8	1.7
Medication: Levothyroxine sodium	3.4	5.8	11.4	-2.7	-1.9	-3.4	-2.4	-2.4	-2.6	-0.6
Loneliness, isolation	3.4	4.6	7.7	2.8	1.9	1.9	1.7	2.6	2.1	-1.8
Smoking Status	3.3	7.9	15.2	-3.1	-2.0	-2.5	-2.6	-3.6	-0.0	3.9
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	6.5	2.0	1.8	2.1	-0.7	2.1	2.6	-1.4
Allergy	3.1	7.1	13.2	-3.6	-3.0	-2.6	-1.4	-3.3	-2.1	1.9
Eye problems/disorders: None of the above	3.1	3.5	7.0	-1.8	-2.1	-2.3	-2.7	-1.7	-1.3	-0.7
Unable to work because of sickness or disability	3.1	4.0	7.5	-2.1	-2.2	-1.9	-0.0	-2.1	-2.7	1.9
Mouth/teeth dental problems: Loose teeth	3.0	3.5	8.8	-1.8	-2.1	-1.8	-3.0	-1.7	-1.4	0.3
Asthma (self-reported)	3.0	6.0	11.8	2.6	2.2	2.0	-0.1	2.8	2.6	-3.4
Trunk fat percentage	2.8	11.1	17.7	4.2	3.5	3.8	3.5	3.7	2.2	-1.4
Tense / ‘highly strung’	2.7	4.5	7.9	2.8	2.4	2.3	1.2	2.7	1.8	-1.0
Systolic blood pressure, automated reading	2.6	7.5	13.0	-2.5	-3.1	-3.3	-0.3	-3.0	-3.6	1.9
Hayfever, allergic rhinitis or eczema	2.6	5.7	10.4	3.2	2.7	2.5	0.8	2.9	1.9	-1.7
Mouth/teeth dental problems: Dentures	2.6	4.4	7.3	-2.3	-2.2	-2.5	-0.4	-2.7	-1.7	1.8
Mineral and other dietary supplements	2.5	3.4	12.2	1.6	1.3	1.6	-0.5	2.0	0.9	-3.5
Age when periods started (menarche)	2.4	5.8	9.1	-3.0	-2.5	-3.0	-2.1	-2.6	-2.1	0.9
Trunk fat mass	2.4	10.4	17.7	3.9	3.2	3.7	4.2	3.4	1.6	-1.2
Arm fat percentage (left)	2.4	9.8	14.8	3.8	3.2	3.9	3.8	3.3	1.8	-0.9
Myopia	2.4	3.5	8.8	-2.4	-1.6	-1.8	-3.0	-1.6	-0.7	1.1
Hair/balding pattern: Pattern 2	2.3	2.9	6.8	-1.6	-2.1	-1.5	-0.2	-1.9	-2.6	1.1
Asthma	2.3	4.5	10.1	2.2	1.8	1.5	-0.3	2.4	2.3	-3.2
Body fat percentage	2.3	9.2	14.7	3.8	3.2	3.6	3.2	3.3	1.8	-1.1
Hypothyroidism (self reported)	2.2	5.0	8.8	-2.8	-1.9	-3.0	-1.7	-2.7	-2.0	0.8
Arm fat percentage (right)	2.2	8.5	13.2	3.6	3.0	3.6	3.5	3.0	1.6	-0.8
Eye problems/disorders: Cataract	2.2	2.6	3.9	1.3	2.0	1.8	1.9	1.2	1.6	1.3
Pack years of smoking	2.2	3.3	6.2	-2.1	-1.9	-1.3	-0.2	-2.1	-1.7	2.5
Respiratory disease	2.1	4.7	9.1	2.6	1.9	1.7	0.4	2.6	2.0	-3.0
Impedance of arm (left)	2.1	9.6	21.7	3.0	2.7	1.6	-1.9	3.4	4.7	-3.3
Arm fat mass (right)	2.1	8.7	20.0	3.5	2.7	3.6	4.5	2.8	0.8	-0.5
Mean time to correctly identify matches	2.1	4.0	17.1	-1.8	-0.4	-1.5	-4.1	-0.9	0.7	-2.0
Whole body fat mass	2.1	8.7	17.6	3.5	2.8	3.4	4.2	3.0	1.1	-0.8
Arm fat mass (left)	2.1	8.6	22.1	3.4	2.6	3.4	4.7	2.7	0.6	-0.4
Verbal and Numeric Reasoning (VNR)	2.0	4.8	13.0	1.4	2.6	1.2	-1.0	2.4	3.6	-1.8
Hand grip strength (left)	2.0	5.4	9.1	-1.9	-2.2	-1.2	2.7	-2.6	-3.0	2.2
Pack years adult smoking proportion	2.0	3.0	5.1	-2.0	-1.9	-1.3	0.1	-1.9	-1.8	2.2
Qualifications: None of the above	2.0	4.3	8.2	-2.1	-1.9	-1.8	-1.0	-2.9	-1.7	2.5
Medication: Paracetamol	2.0	3.3	5.6	-1.1	-1.7	-0.8	2.4	-1.7	-2.4	2.0
BMI	1.9	10.8	31.4	3.3	2.4	4.5	5.6	2.6	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	9.7	1.1	1.0	1.2	3.1	0.9	0.2	-0.6
Impedance of arm (right)	1.9	8.7	18.7	2.7	2.4	1.2	-2.6	3.2	4.3	-3.4
Hip circumference	1.9	8.2	23.6	3.0	2.5	3.5	4.9	2.5	0.5	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.9	-1.3	-1.5	-1.2	0.6	-1.6	-1.9	2.0
Cholesterol lowering medication	1.9	2.8	5.1	-1.6	-1.8	-1.6	-1.1	-2.1	-1.0	2.3
Depressed Affect (Nagel 2018)	1.8	3.9	7.6	2.8	2.0	2.2	1.5	2.4	1.1	-1.2
Reaction Time	1.8	3.3	12.1	-1.3	-0.4	-1.5	-3.5	-0.7	0.2	-2.6
Hand grip strength (right)	1.8	4.9	9.5	-2.0	-2.4	-1.3	1.8	-2.5	-3.1	2.0
Serious illness, injury or assault to yourself	1.8	2.1	3.2	1.7	1.8	1.0	0.2	1.7	1.4	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	7.2	2.7	1.3	1.1	1.4	2.2	1.2	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	3.4	-1.5	-1.8	-1.5	-0.8	-1.5	-1.7	0.9
Leg fat mass (right)	1.8	6.8	15.1	3.0	2.4	3.3	3.9	2.6	0.6	-0.3
Medication for cholesterol	1.8	2.8	4.2	2.0	1.3	2.0	1.1	2.1	1.4	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.1	-1.2	-1.9	-1.2	0.5	-1.3	-2.0	1.5
Intelligence (Savage-Jansen 2018)	1.7	5.2	13.8	1.7	2.1	1.8	-0.8	2.9	3.7	-1.8
Schizophrenia vs Biploar Disorder	1.7	2.2	5.3	-1.0	-1.5	-1.9	-2.3	-0.8	-0.5	-1.6
Body Mass Index (BMI) (2010)	1.7	2.3	11.1	1.3	0.7	1.2	3.3	0.9	-0.8	-0.2
Allergy or Eczema	1.7	4.6	9.1	3.0	2.1	2.2	1.1	2.8	1.5	-1.5
Relative age of first facial hair	1.7	3.5	5.4	2.3	2.0	1.7	1.7	2.3	1.5	-1.3
Chronic bronchitis/emphysema (father)	1.7	1.9	4.2	-1.3	-1.1	-1.3	0.4	-2.0	-1.4	1.6
Illnesses of siblings	1.7	2.3	3.9	1.6	1.9	2.0	-0.3	1.7	1.6	-0.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	7.3	-2.1	-1.3	-2.7	-1.3	-2.3	-1.5	0.4
Medication for pain relief, constipation, heartburn	1.7	3.0	4.9	1.1	1.4	1.6	-2.2	1.9	1.9	-1.8
Heart disease (mother)	1.7	2.1	4.5	1.8	1.4	1.1	0.3	1.8	0.8	-2.1
Friendships satisfaction	1.7	2.1	4.9	-0.8	-1.5	-2.2	-0.3	-0.8	-1.9	-1.6
Medication: Gliclazide	1.7	1.9	3.0	-1.2	-1.5	-1.2	0.3	-1.6	-1.6	1.7
Age started oral contraceptive pill	1.7	2.1	3.1	1.5	1.8	1.8	-0.8	1.6	1.6	-0.9
Systolic Blood Pressure	1.6	8.0	12.8	-2.7	-3.5	-3.6	-1.0	-2.9	-3.5	1.2
Weight	1.6	7.8	26.1	2.9	2.3	3.1	5.1	2.4	-0.0	-0.3
Noisy workplace	1.6	2.0	4.0	-1.4	-0.6	-1.2	0.8	-1.9	-2.0	1.5
Medication: Allopurinol	1.6	2.1	3.5	1.8	1.3	1.3	0.6	1.9	1.4	-1.5
Ever had bowel cancer screening	1.6	1.8	3.6	-1.2	-1.2	-0.9	-0.7	-1.7	-1.4	1.9
Medication: Aspirin	1.6	2.1	4.5	-1.5	-1.1	-2.1	-0.3	-1.9	-1.0	1.3
Guilty feelings	1.6	2.5	6.3	2.0	0.6	0.7	-0.9	2.2	0.4	-2.5
Average weekly spirits intake	1.5	1.9	4.6	-1.8	-0.4	-1.2	-0.0	-1.9	0.3	2.2
Supplements: Zinc	1.5	1.7	3.1	1.8	1.0	1.3	1.4	1.4	1.3	0.3
High blood pressure (siblings)	1.5	2.2	3.7	-1.4	-1.6	-1.5	1.0	-1.8	-1.9	0.9
Leg fat percentage (right)	1.5	5.4	10.0	2.8	2.4	3.2	2.6	2.5	1.0	-0.3
Medication: Aspirin	1.5	2.0	4.1	-1.4	-0.9	-1.7	0.1	-1.9	-0.7	2.0
Commuting to job workplace: Public transport	1.5	1.8	4.3	-1.3	-1.0	-2.1	-1.7	-0.7	0.2	-1.6
Leg fat mass (left)	1.5	5.9	15.3	2.7	2.1	3.1	3.9	2.2	0.2	0.2
Ulcerative Colitis (UC)	1.4	2.7	4.4	-1.5	-2.1	-1.9	-0.9	-1.8	-2.0	0.5
Bipolar Disorder (2011)	1.4	1.4	3.2	-0.9	-0.8	-1.2	0.8	-1.3	-1.8	1.1
Leg fat-free mass (left)	1.4	7.2	30.5	2.3	1.7	2.7	5.5	1.9	-0.3	-0.4
Leg predicted mass (left)	1.4	7.5	31.5	2.4	1.8	2.8	5.6	2.0	-0.2	-0.4
Neuroticism score	1.4	2.9	6.7	2.6	1.2	1.2	-0.4	2.4	1.1	-1.8
Birth weight of first child	1.4	2.5	14.1	0.8	0.1	0.9	3.8	0.0	-1.3	0.7
Medication: Amlodipine	1.4	1.9	3.4	-1.8	-1.3	-1.3	-0.7	-1.4	-1.8	1.1
Qualifications: nursing, teaching	1.4	2.2	4.7	1.3	1.6	1.5	1.7	1.3	2.2	0.3
Impedance of whole body	1.4	6.9	13.6	2.2	1.9	0.6	-2.9	2.7	3.7	-3.1
Body mass index (BMI)	1.3	5.4	17.8	2.3	1.7	3.0	4.2	1.5	-0.5	0.8
Blood clot in the leg (DVT)	1.3	1.7	8.1	0.6	1.0	0.9	2.8	-0.1	-0.5	1.2
Birth weight	1.3	2.8	14.2	-0.7	-0.5	-0.3	3.8	-1.3	-1.2	1.2
Health satisfaction	1.3	1.7	4.0	-1.0	-1.4	-2.0	0.4	-1.5	-1.4	0.6
Medication: Seretide 50 evohaler	1.3	1.5	5.5	0.8	0.5	0.4	-2.3	0.7	0.2	-1.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.1	-1.4	-1.3	-1.2	-1.0	-1.4	-0.1	1.5
Illnesses of father: High blood pressure	1.3	1.7	8.4	0.7	0.3	0.1	-1.1	1.1	-0.6	-2.9
Alcohol drinker status: Never	1.3	1.5	7.6	0.9	0.5	0.9	-0.1	1.0	0.3	-2.8
Leg fat percentage (left)	1.3	4.6	8.5	2.6	2.2	2.9	2.8	2.1	0.6	0.2
Heart disease (siblings)	1.3	1.6	5.6	-1.0	-1.7	-2.4	-0.2	-1.0	-0.7	-0.1
Blood Eosinophil Count	1.2	8.9	26.5	3.4	1.6	1.7	-0.5	4.2	0.5	-5.2
Nervous feelings	1.2	2.3	9.6	0.5	-0.5	-1.2	-3.1	0.6	0.8	-1.8
Had other major operations	1.2	1.5	5.5	0.8	1.5	0.4	-1.1	0.7	2.3	0.5
Comparative body size at age 10	1.2	3.4	9.5	-0.9	-1.3	1.0	2.3	-1.1	-3.1	2.1
Leg fat-free mass (right)	1.2	6.5	31.0	2.0	1.4	2.4	5.6	1.5	-0.7	-0.2
Breast cancer (self-reported)	1.2	1.5	5.3	1.0	1.4	1.2	-0.0	0.8	2.3	0.4
Leg predicted mass (right)	1.2	6.5	31.1	2.0	1.4	2.4	5.6	1.5	-0.6	-0.1
Wears glasses or contact lenses	1.2	1.4	5.8	0.6	1.3	1.3	2.4	0.5	0.5	-0.1
Average weekly beer plus cider intake	1.2	1.7	4.1	-1.2	-1.2	-1.9	-2.0	-1.1	-0.5	-0.1
Pain experienced in last month	1.2	2.1	4.3	1.1	1.1	1.2	-1.7	1.6	0.9	-2.1
Neuroticism (Nagel 2018)	1.1	2.5	5.4	2.3	1.3	1.1	-0.3	2.1	1.0	-1.9
Neuroticism (2016)	1.1	1.6	3.8	1.9	1.0	1.5	0.1	1.2	1.5	0.5
Ever had hysterectomy (womb removed)	1.1	1.3	2.1	1.4	0.9	0.7	-0.8	1.3	1.5	-1.0
Number of incorrect matches in round	1.1	1.8	4.3	1.6	1.2	1.7	2.1	1.1	0.1	-0.6
Past tobacco smoking	1.1	2.0	9.3	-0.3	-0.3	0.3	3.1	-0.2	-2.0	-0.5
Breastfed as a baby	1.1	1.3	2.7	1.0	1.1	0.7	-0.8	1.6	1.6	-0.9
Arm fat-free mass (right)	1.1	5.5	29.4	1.2	0.7	1.7	5.4	0.6	-2.0	0.5
Number of full brothers	1.1	1.4	3.1	0.7	1.1	0.2	-1.2	1.2	1.8	-1.5
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.1	-0.8	-1.3	-1.1	-0.4	-1.0	-1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.6	1.7	1.1	1.4	1.7	2.1	0.8	-1.5
Hearing aid user	1.1	1.2	1.7	1.1	1.0	1.3	1.2	1.0	1.0	-0.9
Mother’s age at death	1.1	1.4	3.2	1.0	1.8	0.7	-0.1	1.1	1.7	-0.9
High cholesterol (Self-reported)	1.1	2.0	3.5	-1.5	-1.6	-1.7	-0.7	-1.9	-1.0	1.0
Medication: Paracetamol	1.1	1.7	3.7	-0.7	-1.4	-0.8	1.7	-1.3	-1.9	0.7
Ever smoked	1.1	1.9	7.9	0.2	0.4	-0.2	-2.8	0.3	2.2	0.5
Basal metabolic rate	1.1	6.0	29.6	1.8	1.1	2.1	5.4	1.3	-1.2	-0.1
Fractured/broken bones in last 5 years	1.1	1.5	2.6	1.6	1.6	0.9	1.0	1.2	1.1	-0.8
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	1.4	0.7	1.5	1.4	1.3	1.0	-0.2
Depression (Nagel 2018)	1.0	1.5	3.0	-0.9	-1.7	-1.6	0.4	-1.2	-1.6	0.2
Crohns Disease (2017)	1.0	2.2	5.5	2.3	1.5	1.1	0.8	2.1	0.6	-0.7
Medication for hormone replacement therapy	1.0	1.2	3.3	-1.0	-1.0	-0.8	0.4	-1.1	-1.0	1.8
Headache pain in last month	1.0	1.8	7.1	-0.2	-0.5	-0.5	2.7	-0.7	-1.1	1.7
Qualifications: College or University degree	1.0	3.1	7.1	0.9	1.4	0.9	-2.0	1.8	2.7	-1.9
Smoking status: Previous	1.0	1.4	3.9	1.0	1.0	0.6	-1.7	0.8	2.0	0.5
Alcohol drinker status: Previous	1.0	1.1	2.0	-1.3	-1.2	-1.4	-0.6	-1.1	-1.0	-0.2
Bipolar Disorder (2018)	0.9	1.5	3.5	-0.8	-0.9	-0.6	1.4	-1.2	-1.9	1.1
Alzheimer’s Disease (in mother)	0.9	1.1	4.0	-0.7	-0.9	-1.1	-2.0	-0.3	-0.7	-0.8
High blood pressure (mother)	0.9	1.3	3.1	-0.9	-1.5	-0.6	0.2	-1.2	-1.8	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.8	-0.1	0.6	-0.0	-2.6	0.8	0.9	-2.3
Exposure to tobacco smoke at home	0.9	1.0	2.0	-1.2	-1.4	-0.7	-0.4	-1.0	-1.3	0.2
Exposure to tobacco smoke outside home	0.9	1.2	7.0	-0.4	-0.3	-0.6	-2.6	-0.1	-0.1	-0.9
Shortness of breath walking on level ground	0.9	1.1	3.7	-0.6	-0.7	-1.2	-1.9	-0.7	-1.1	-0.2
Arm predicted mass (right)	0.9	4.7	25.5	0.8	0.2	1.2	5.0	0.2	-2.3	0.7
Family relationship satisfaction	0.9	1.2	6.6	0.5	-0.1	-1.0	-0.4	0.4	-0.2	-2.6
Whole body fat-free mass	0.9	5.3	28.3	1.4	0.7	1.7	5.3	0.9	-1.6	0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	0.7	1.0	1.4	0.5	0.9	1.8	0.2
Whole body water mass	0.9	5.0	27.2	1.3	0.7	1.6	5.2	0.8	-1.7	0.2
Arm fat-free mass (left)	0.9	4.5	24.2	0.7	0.2	1.2	4.9	0.2	-2.3	0.7
Irritability	0.9	1.6	3.6	1.9	0.9	1.4	1.6	1.3	0.5	-0.4
Arm predicted mass (left)	0.9	4.4	23.1	0.7	0.2	1.0	4.8	0.2	-2.3	0.7
HbA1C	0.8	0.9	1.8	-0.6	-0.8	-0.6	1.2	-1.1	-0.6	1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.5	-1.2	-1.0	-1.0	-0.6	-1.0	-1.2	0.4
Medication: Co-codamol	0.8	0.9	1.6	-1.0	-1.2	-0.9	-1.1	-0.8	-0.3	0.9
Supplements: Glucosamine	0.8	1.1	2.7	0.6	1.0	1.0	0.0	0.6	1.6	1.4
Waist circumference	0.8	2.9	4.8	2.2	1.5	2.1	2.1	1.8	0.5	-0.7
Fluid intelligence score	0.8	1.6	4.9	0.5	1.3	0.8	-0.2	1.4	2.2	-1.4
Happiness	0.8	0.9	2.4	-0.2	-0.7	-1.2	-0.0	-0.3	-1.4	-1.6
Pulse wave reflection index	0.8	1.0	2.4	1.2	1.2	0.7	1.5	0.9	0.4	-0.2
Loud music exposure frequency	0.8	0.8	2.6	0.1	-0.2	-0.6	-1.6	0.6	0.4	-1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.4	1.1	1.2	1.1	0.6	0.7	1.2	0.1
Worry too long after embarrassment	0.8	1.3	6.1	-0.0	-0.7	-1.5	-2.5	-0.1	0.3	-0.2
Age at first live birth	0.8	1.5	2.9	1.0	1.3	1.7	-0.1	1.6	1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.8	1.0	1.4	2.0	1.6	1.3	1.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	5.1	0.1	0.6	0.2	2.3	-0.4	-0.9	0.8
Rheumatoid Arthritis	0.7	0.9	2.2	-1.1	-1.1	-0.7	-1.5	-0.8	-0.2	0.8
Blood Platelet Count	0.7	7.8	13.0	-3.3	-3.0	-1.7	-0.1	-3.0	-3.6	3.2
Waist Hip Ratio (WHR)	0.7	3.4	15.7	-0.7	-1.0	-1.6	-4.0	-0.4	0.9	-1.7
Average weekly fortified wine intake	0.7	0.8	1.9	0.7	0.8	1.1	-0.6	1.4	0.9	-0.5
High blood pressure	0.7	2.1	4.3	-1.2	-1.9	-1.8	0.1	-1.4	-2.1	0.1
Hearing difficulty/problems with background noise	0.7	1.1	2.5	-0.8	-0.4	-1.3	-1.6	-0.8	0.5	1.3
Trunk fat-free mass	0.7	3.9	20.4	0.4	-0.2	0.6	4.5	-0.0	-2.5	0.5
Trunk predicted mass	0.7	3.9	20.2	0.5	-0.2	0.7	4.5	0.0	-2.5	0.4
Length of working week for main job	0.7	0.8	1.8	1.0	1.1	1.3	0.7	0.9	0.3	0.3
Medication: Omeprazole	0.7	0.8	1.8	-0.7	-0.9	-1.3	-1.3	-0.7	-0.2	-0.5
Had major operations	0.7	0.8	2.2	-0.8	-0.6	-1.5	-1.4	-0.6	-0.1	-0.2
Leg pain on walking	0.7	0.9	3.5	-0.3	-0.9	0.1	-0.9	-0.8	-0.3	1.9
Financial situation satisfaction	0.7	0.8	3.0	1.0	0.4	-0.1	0.5	1.0	0.5	-1.7
Medication: Blood pressure	0.7	1.4	2.8	-1.2	-1.0	-1.7	-1.0	-1.3	-1.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.0	-0.8	-0.7	-1.4	-0.7	-0.7	-1.2	0.5
Diastolic blood pressure, automated reading	0.7	2.1	7.9	-0.1	-1.3	-0.5	2.1	-0.6	-2.8	0.3
Ulcerative Colitis	0.6	0.9	1.6	-0.9	-1.3	-1.1	-0.8	-1.0	-1.0	-0.2
Heel T-Score	0.6	4.9	10.1	1.4	1.9	1.2	-2.7	2.1	3.2	-2.3
Neuroticism	0.6	1.4	3.0	1.7	0.7	0.4	-1.0	1.4	0.8	-1.7
Sensitivity / hurt feelings	0.6	1.0	2.1	1.4	0.5	0.5	-0.6	1.4	1.1	-0.8
Impedance of leg (right)	0.6	3.0	10.9	0.7	0.4	-0.6	-3.3	1.3	1.8	-2.1
Pain all over the body in last month	0.6	0.7	2.0	-0.6	-0.4	-0.6	0.5	-1.1	0.6	1.4
Lung cancer (father)	0.6	0.7	3.1	-0.5	-0.6	-0.9	-1.8	-0.0	0.5	-0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	1.2	1.0	0.1	0.9	0.9	0.1	-0.7
Neck or shoulder pain in last month	0.6	0.9	1.9	-0.7	-0.5	-1.0	1.2	-1.0	-0.3	1.4
Alcohol intake frequency.	0.6	1.3	3.6	1.2	0.9	1.0	1.0	1.1	0.1	-1.9
Hypertension (Self-reported)	0.6	1.6	3.2	-1.0	-1.6	-1.7	-0.1	-1.1	-1.8	-0.5
Mood swings	0.6	1.0	2.5	1.5	0.7	1.0	1.6	0.9	-0.1	0.1
Ever depressed for a whole week	0.6	0.8	2.0	-0.7	-1.0	-1.4	-0.8	-0.5	-0.7	-0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.1	1.0	1.6	1.7	-0.2	1.2	1.8	0.3
Blood White Count	0.5	3.8	6.8	-1.3	-2.6	-1.8	-2.5	-1.2	-2.6	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	0.6	0.5	1.0	1.8	0.0	-0.2	1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.5	0.4	0.5	0.0	1.9	-0.1	0.6	0.4
Vitamin and mineral supplements	0.5	0.7	2.2	-0.9	-0.6	-0.3	-1.5	-0.6	-1.0	-0.6
Multivitamins +/- minerals	0.5	0.6	3.5	0.4	0.4	0.1	1.9	0.1	0.2	0.8
Impedance of leg (left)	0.5	2.3	10.1	0.5	0.1	-0.9	-3.2	0.8	1.2	-1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.0	1.4	0.6	0.4	-0.2	1.4	0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	6.7	0.9	0.9	1.5	2.6	1.2	-0.2	-0.4
Depression (self-reported)	0.5	0.6	1.6	1.2	0.7	0.5	1.3	0.8	-0.1	0.1
Medication: Lansoprazole	0.5	0.6	1.3	-0.7	-0.8	-1.1	0.4	-0.6	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	7.3	0.5	0.6	1.2	2.7	0.9	-0.3	-0.1
Peak expiratory flow (PEF)	0.5	1.3	5.8	0.4	0.3	0.6	2.4	0.6	-1.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	1.1	0.8	0.5	0.3	1.0	0.2	-1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-1.2	-0.8	-1.2	-0.9	-0.9	-0.2	0.7
Gout (self-reported)	0.5	0.7	2.3	0.9	0.4	0.5	0.6	0.9	0.6	-1.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	0.7	0.8	1.0	0.1	0.8	0.9	-0.9
Emphysema/chronic bronchitis	0.5	0.5	3.2	-0.1	-0.1	-0.1	0.2	-0.5	-0.0	1.8
Suffer from ‘nerves’	0.5	0.8	3.0	-0.4	-1.0	-1.7	-0.9	-0.6	-0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	-0.8	-0.4	-1.2	-0.4	-0.9	-0.2	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.7	1.4	-1.2	-1.0	0.1	-0.3	-0.9	-1.0	0.5
Back pain experienced in last month	0.5	0.8	2.2	-0.3	-0.2	-0.2	1.5	-0.7	-0.9	1.3
Number of self-reported non-cancer illnesses	0.5	0.9	3.3	1.2	0.9	0.2	1.8	0.6	-0.3	0.1
Number of operations (self-reported)	0.5	0.7	1.7	-0.3	0.2	-1.3	-1.2	-0.5	1.2	-0.2
Worry (Nagel 2018)	0.4	0.9	1.9	1.3	0.1	-0.3	-1.2	0.9	0.3	-1.4
Coronary Artery Disease (CAD)	0.4	0.5	1.4	-0.4	0.0	-0.8	-1.2	-0.4	0.3	-0.9
LDL Cholesterol	0.4	0.6	1.0	-0.7	-1.0	-0.4	-0.1	-1.0	-0.8	0.9
Severe depression (siblings)	0.4	0.5	1.4	-0.5	-1.0	-0.8	-0.0	-0.2	-1.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	-0.5	-0.5	-0.6	-0.6	-0.3	-1.2	0.2
Medication: Atenolol	0.4	0.6	0.9	-0.7	-0.9	-0.8	-0.4	-0.9	-0.7	0.7
Sitting height	0.4	3.0	12.8	1.4	1.2	1.7	3.6	1.4	0.3	0.3
Had menopause	0.4	0.5	1.4	0.3	0.8	0.7	1.2	0.1	0.9	-0.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.2	-0.4	-0.6	-1.1	-0.8	-0.6	-0.6	-0.2
Diabetes (self-reported)	0.4	0.6	2.1	0.4	0.4	0.7	1.1	0.1	-0.1	1.4
Medication: Simvastatin	0.4	0.6	1.6	-1.0	-0.6	-0.4	0.3	-1.3	-0.6	0.8
Number of live births	0.4	0.5	1.6	-0.7	-0.7	-0.6	0.1	-0.9	0.0	1.3
Illnesses of mother	0.4	0.5	1.1	-1.1	-0.4	-0.5	-0.3	-1.0	-0.1	0.8
Hair/balding pattern: Pattern 4	0.4	1.1	2.8	0.5	0.6	0.2	-1.5	1.0	1.7	-0.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	1.3	0.5	0.2	-0.1	1.1	1.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.6	-0.9	-0.9	0.1	-0.3	-1.1	-0.4
Pulse wave peak to peak time	0.4	0.5	1.3	-1.1	-0.9	-0.2	-0.7	-0.7	-0.1	0.5
Migraine (self-reported)	0.4	0.5	2.9	-0.3	0.1	-0.4	1.7	-0.3	-0.6	0.4
Knee pain experienced in last month	0.4	0.7	2.4	0.8	0.3	0.7	1.5	0.1	0.5	1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.0	0.8	0.6	1.0	0.7	0.6	0.7	-0.9
Major Depression (MDD)	0.3	0.4	0.7	0.8	0.4	0.8	-0.6	0.5	0.6	-0.0
Breast Cancer	0.3	0.8	3.3	0.9	0.6	0.7	1.8	0.6	-0.4	-0.5
Ovarian Cancer	0.3	0.4	1.4	0.1	0.8	0.8	-0.1	0.3	1.2	0.0
Cardiovascular Disease	0.3	1.1	2.1	-0.9	-1.4	-1.5	0.3	-1.2	-1.3	-0.1
Lung FEV1/FVC ratio	0.3	1.6	4.0	1.1	-0.0	1.4	1.7	1.1	-2.0	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	-0.0	-0.6	-0.6	1.2	-0.2	-0.9	0.2
Taking other prescription medications	0.3	0.4	0.7	0.8	0.9	-0.1	0.3	0.6	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	0.4	1.1	0.3	-0.9	0.7	1.5	-0.5
Qualifications: CSEs or equivalent	0.3	0.3	0.7	0.8	0.4	0.8	0.7	0.5	-0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.7	-0.2	-0.1	0.0	0.3	-0.5	-0.5	1.3
Alcohol usually taken with meals	0.3	0.6	2.5	0.5	0.4	0.7	1.6	0.5	0.1	-0.4
Forced vital capacity (FVC)	0.3	1.1	3.3	0.5	1.0	1.2	1.8	0.9	0.7	-0.6
Time employed in main current job	0.3	0.3	1.5	-0.2	-0.5	-0.5	-0.1	-0.2	-1.2	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	2.2	0.3	-0.0	-0.5	-0.3	0.2	-0.1	-1.5
Father’s age at death	0.3	0.4	2.3	-0.5	-0.2	-0.3	-1.5	0.1	-0.1	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	-0.4	-0.3	-0.6	-0.8	-0.6	-0.0	1.2
Medication: Cholesterol lowering	0.3	0.5	1.6	0.8	0.6	0.7	1.3	0.5	0.0	0.1
Prospective memory result	0.3	0.4	0.9	0.9	0.3	0.6	0.4	0.7	-0.3	0.8
Standing height	0.3	2.7	6.9	1.5	1.0	0.2	2.6	1.8	0.5	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.3	-0.2	-0.7	-0.4	0.0	-0.3	-0.7	1.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.3	-0.5	-1.1	0.8	-0.5	-0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-0.9	-1.0	0.6	-0.3	-0.2	0.8
Medication: Ibuprofen	0.3	0.4	0.9	0.9	0.6	0.2	0.6	0.6	0.3	-1.0
Age at last live birth	0.3	0.5	0.9	0.4	0.7	0.9	0.1	0.8	1.0	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.3	0.7	0.9	-0.3	0.6	0.8	0.0
Supplements: Vitamin C	0.3	0.4	0.7	0.5	0.4	0.6	0.8	0.4	0.7	0.6
Illnesses of siblings: Diabetes	0.3	0.3	1.1	-0.7	-0.5	-0.3	-0.1	-0.7	-1.1	0.1
Average weekly red wine intake	0.3	0.5	1.3	0.0	0.7	0.5	1.1	-0.1	0.7	1.0
Diabetes diagnosed by doctor	0.3	0.4	1.2	0.5	0.5	0.6	1.0	0.1	0.1	1.1
Osteoporosis (self-reported)	0.3	0.4	1.5	0.0	-0.1	-0.2	0.1	-0.0	-1.0	-1.2
Osteoarthritis (self-reported)	0.3	0.4	1.3	0.4	0.7	0.5	0.5	0.0	0.4	1.2
Miserableness	0.3	0.6	1.2	1.1	0.4	1.1	0.9	0.7	0.2	0.5
Ever taken oral contraceptive pill	0.3	0.4	1.9	-0.0	-0.0	-0.5	-1.4	-0.0	0.6	-0.5
Medication: Bendroflumethiazide	0.3	0.5	0.8	0.4	0.9	0.8	-0.6	0.7	0.3	-0.7
Commuting to job workplace: Cycle	0.3	0.4	1.0	0.6	0.5	1.0	0.4	0.6	0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	0.2	-0.1	-0.6	-0.9	0.2	0.7	-1.1
Crohns Disease (2012)	0.2	0.3	0.9	0.9	0.2	-0.2	0.9	0.7	-0.1	0.0
Fasting Glucose	0.2	0.2	0.9	0.3	-0.2	0.2	0.9	0.3	0.4	-0.1
Lupus	0.2	0.2	0.5	-0.4	0.2	0.1	0.6	-0.7	-0.3	0.7
Height	0.2	3.5	9.4	1.9	1.2	0.2	3.1	2.1	0.8	-2.3
Lung FVC	0.2	1.0	2.9	-1.7	-0.7	-0.3	0.0	-1.1	-0.1	1.5
Hair Pigment	0.2	4.9	8.8	-2.9	-2.0	-2.1	-0.6	-2.9	-0.5	3.0
Number of treatments/medications taken	0.2	0.4	1.8	0.5	0.4	-0.7	1.3	-0.2	-0.1	0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.6	-0.0	-0.7	-0.8	-0.2	0.9	0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	0.1	0.0	-0.4	-0.9	0.1	0.2	-0.7
Medication: Metformin	0.2	0.2	1.4	0.2	0.0	0.3	0.4	-0.1	-0.1	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.3	-0.8	-0.4	0.4	-0.0	-0.6	0.0
Relative age voice broke	0.2	0.4	1.2	-0.4	-0.5	-0.7	0.6	-0.0	-1.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.3	-0.6	0.0	0.4	-0.6	-0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.6	0.7	-0.3	-0.1	-0.6	0.8	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.1	0.0	0.5	-0.3	-1.4	0.3	1.1	-0.5
Heart attack	0.2	0.2	1.0	0.4	0.3	0.1	1.0	0.1	-0.5	0.2
Worrier / anxious feelings	0.2	0.5	1.5	1.2	0.1	0.1	-0.1	0.9	0.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.8	0.4	0.3	0.6	0.6	0.2	-0.5
Glaucoma (self-reported)	0.2	0.2	0.6	0.6	0.0	0.2	-0.2	0.8	0.4	0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	2.5	0.1	0.5	0.6	1.6	0.6	0.5	-0.5
Overall health rating	0.2	0.4	1.1	0.4	-0.5	-0.7	0.4	-0.1	-1.1	-0.4
Chest pain or discomfort	0.2	0.2	0.6	0.5	-0.4	-0.7	0.3	0.5	-0.3	-0.6
Commuting to job workplace: Walk	0.2	0.2	1.1	-0.4	-0.5	-0.1	0.0	-0.3	0.4	1.0
Medication: Lisinopril	0.2	0.3	0.8	0.6	0.9	0.7	0.3	0.5	0.3	-0.2
Medication: Atorvastatin	0.2	0.3	0.7	0.8	0.3	-0.2	0.4	0.6	0.8	0.5
Risk taking	0.2	0.4	1.1	0.5	0.6	0.1	-0.7	0.5	1.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	0.5	0.3	-0.0	1.0	0.1	-0.5	-0.0
Irritable Bowel Disease (IBD)	0.1	0.3	1.2	0.4	-0.4	-0.6	0.0	0.0	-1.1	-0.2
Prostate Cancer	0.1	0.2	0.3	0.2	0.6	0.3	-0.5	0.6	0.5	-0.2
Mean Putamen Volume	0.1	0.2	0.4	-0.0	0.2	0.6	-0.5	-0.1	-0.3	0.6
HDL Cholesterol	0.1	0.1	0.4	0.2	0.2	0.3	0.0	0.4	-0.5	0.6
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.1	-0.6	-0.2	-0.3	-0.1	0.2	-0.5
Triglycerides	0.1	0.1	0.7	0.1	0.2	0.3	-0.4	-0.3	0.8	-0.0
Blood Red Count	0.1	0.7	1.5	-0.9	-0.6	-0.5	-1.2	-0.5	-1.0	-0.9
Tanning	0.1	0.9	1.7	-1.3	-1.2	-1.1	-0.6	-1.0	-0.3	0.7
Angina	0.1	0.2	0.6	0.3	-0.5	-0.4	0.8	0.0	-0.5	0.1
Diabetes (father)	0.1	0.1	0.3	0.3	-0.2	0.1	0.2	0.0	-0.4	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.5	-0.3	-0.4	0.2	-0.3	0.4	0.5
Financial difficulties in last 2 years	0.1	0.1	0.3	0.4	-0.3	-0.1	-0.6	0.4	0.0	0.1
Mouth/teeth dental problems	0.1	0.1	0.4	-0.0	0.4	0.6	0.3	0.0	0.2	0.6
Medication: Ramipril	0.1	0.1	0.3	-0.2	-0.4	-0.3	0.4	-0.5	-0.5	0.1
Falls in the last year	0.1	0.1	0.5	-0.1	-0.1	-0.5	-0.2	0.2	-0.5	-0.7
Pulse rate	0.1	0.2	0.6	0.6	0.3	0.8	0.3	0.7	-0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.1	0.5	-0.2	-0.5	0.3	0.2	-0.2
Medication: Blood pressure	0.1	0.2	0.7	0.5	0.2	0.6	0.1	0.4	-0.3	-0.8
Angina (self-reported)	0.1	0.2	0.4	0.3	-0.6	-0.4	0.6	0.0	-0.5	0.0
Pulse rate, automated reading	0.1	0.5	2.1	0.0	-0.4	0.5	0.7	0.4	-1.4	0.2
Comparative height size at age 10	0.1	0.7	2.2	0.8	0.8	0.2	1.5	0.6	0.8	0.5
Illnesses of father: Heart disease	0.1	0.2	0.6	0.7	0.0	0.1	0.2	0.5	0.3	-0.8
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.5	-0.1	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.2	-0.2	0.1	0.6	0.4	-0.2	0.6
Eye problems/disorders: Glaucoma	0.1	0.2	0.8	0.3	-0.0	-0.0	-0.1	0.3	0.2	0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.3	-0.2	-0.5	-0.3	-0.4	-0.5	-0.3

Hub : Genes

CENPM

Models

Trait associations