Hub : Genes

FAM109B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0230	6.4e-05	0.018	0.032	0.024	0.03	0.022	2.7e-03	7.4e-05	6.3e-04	0.00012	9.0e-04
2	GTEx	Adipose Subcutaneous	0.0630	0.0320	3.6e-03	0.044	NA	0.026	NA	0.032	1.7e-04	NA	3.3e-03	NA	1.1e-03
3	GTEx	Artery Tibial	0.1644	0.0520	4.9e-06	0.085	NA	0.097	NA	0.077	3.5e-07	NA	4.9e-08	NA	1.2e-06
4	GTEx	Brain Cortex	0.1330	0.0620	6.2e-03	0.096	NA	0.087	NA	0.082	1.3e-03	NA	2.2e-03	NA	2.9e-03
5	GTEx	Cells Transformed fibroblasts	0.1730	0.0680	3.9e-05	0.072	NA	0.063	NA	0.072	4.7e-06	NA	1.7e-05	NA	4.3e-06
6	GTEx	Esophagus Muscularis	0.1540	0.0600	1.1e-04	0.082	NA	0.044	NA	0.059	1.0e-05	NA	1.1e-03	NA	1.8e-04
7	GTEx	Pituitary	0.2840	0.1160	5.9e-03	0.002	NA	0.100	NA	0.019	2.8e-01	NA	1.8e-03	NA	1.1e-01
8	GTEx	Thyroid	0.0730	0.0350	5.4e-04	0.058	NA	0.042	NA	0.045	3.2e-05	NA	3.4e-04	NA	2.2e-04
9	GTEx	Whole Blood	0.0450	0.0210	2.2e-03	0.059	NA	0.042	NA	0.059	4.1e-06	NA	8.8e-05	NA	3.9e-06
10	TCGA	Bladder Urothelial Carcinoma	0.0290	0.0200	4.1e-03	0.025	0.019	0.022	NA	0.021	3.1e-03	8.6e-03	5.4e-03	NA	5.9e-03
11	TCGA	Brain Lower Grade Glioma	0.0395	0.0267	7.9e-04	0.035	0.030	0.025	NA	0.034	7.1e-05	2.4e-04	7.1e-04	NA	8.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.7	2.7	5.2	2.1	1.5	1.3	1.3	-1.3	1.6	-0.1	1.8	2.0	1.9	2.3
Bipolar Disorder or Schizophrenia	9.5	23.1	31.0	5.6	5.0	4.2	5.1	-5.0	5.0	-0.7	5.1	5.2	5.2	5.0
Depressed Affect (Nagel 2018)	0.5	1.1	5.1	0.1	-0.2	-2.2	0.1	-0.4	-0.4	2.2	-0.3	0.1	-0.1	1.4
Depression (Nagel 2018)	4.2	6.3	8.9	2.9	2.4	1.1	2.8	-2.7	2.6	1.7	2.5	3.0	2.7	2.5
Intelligence (Savage-Jansen 2018)	1.5	4.7	27.3	-2.5	-1.5	-0.5	-1.5	1.5	-1.5	-0.9	-1.8	-1.5	-1.5	-5.2
Neuroticism (Nagel 2018)	0.9	2.1	4.0	1.2	1.2	-1.5	1.4	-1.8	1.0	1.5	1.5	1.1	1.1	2.0
Schizophrenia (2018)	11.3	23.5	30.1	5.5	5.2	4.2	5.5	-5.4	5.2	-0.8	5.1	5.0	5.1	4.5
Schizophrenia vs Biploar Disorder	1.5	2.0	3.3	1.3	1.7	1.0	1.8	-1.5	1.6	0.4	1.6	1.4	1.4	1.0
Worry (Nagel 2018)	1.0	2.2	3.9	1.6	1.6	-0.2	1.8	-1.9	1.3	0.3	2.0	1.3	1.3	1.8
Alzheimer’s Disease (in mother)	1.7	2.0	7.7	-0.2	1.6	0.5	1.7	-2.8	1.7	0.9	1.1	1.3	1.4	-0.6
Alzheimer’s Disease (in father)	1.5	1.6	4.2	0.0	1.2	2.1	1.4	-1.7	1.3	-1.4	1.5	0.7	1.0	0.1
Alzheimer’s Disease (including proxy)	1.1	1.7	5.7	0.0	1.3	1.5	1.6	-2.4	1.5	-0.2	1.3	0.9	1.1	0.3
Crohns Disease (2017)	0.3	0.7	4.4	0.1	-0.4	-2.1	-0.7	0.4	-0.4	-0.4	-0.0	-0.2	-0.4	1.4
Irritable Bowel Disease (IBD)	0.4	1.1	4.6	1.2	0.7	-0.8	0.7	-1.1	0.7	-0.9	0.8	0.8	0.6	2.1
Ulcerative Colitis (UC)	1.1	2.0	3.8	1.2	1.3	0.9	1.7	-2.0	1.4	-1.4	1.2	1.4	1.2	1.6
Major Depression (MDD)	0.3	0.4	2.0	1.4	0.7	-0.2	0.8	0.0	0.6	-0.0	0.7	0.4	0.6	0.4
Reaction Time	0.4	0.7	2.5	-1.5	0.4	-0.1	0.1	-0.8	0.1	-1.1	0.8	-0.2	-0.0	-1.6
Verbal and Numeric Reasoning (VNR)	3.5	8.4	27.2	-3.4	-2.6	-1.2	-3.0	2.4	-2.7	0.1	-2.6	-2.9	-2.8	-5.2
Breast Cancer	0.1	0.3	1.3	0.4	0.5	-0.1	0.4	-0.0	0.6	-0.1	0.1	0.8	0.8	1.1
Ovarian Cancer	2.4	3.2	5.5	-1.7	-2.0	-2.3	-1.6	0.9	-2.0	-0.2	-2.2	-2.1	-1.9	-1.7
Prostate Cancer	0.2	0.3	1.3	-1.0	0.2	-0.2	-0.4	0.0	0.2	-0.8	-0.2	-0.2	-0.0	-1.1
Age at First Birth	0.7	1.1	2.7	-1.6	-0.6	-1.6	-1.0	-0.0	-0.8	-0.1	-1.2	-0.6	-0.7	-1.6
Bipolar Disorder (2011)	0.3	0.3	2.2	1.5	0.3	-0.2	0.1	-0.0	0.4	-0.2	0.5	0.5	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.3	2.3	0.7	-0.5	-1.5	-0.2	0.3	-0.6	-0.5	-0.3	0.1	0.0	0.0
Coronary Artery Disease (CAD)	0.4	0.5	1.4	-0.4	-0.7	-0.5	-0.6	0.6	-0.7	-0.7	-1.2	-0.9	-0.6	-0.7
Crohns Disease (2012)	0.3	0.5	1.9	0.2	-0.4	-1.4	-0.5	0.2	-0.4	-1.2	-0.3	-0.1	-0.3	1.3
Mean Putamen Volume	0.5	0.5	1.5	-1.2	-0.4	-0.8	-0.5	0.6	-0.4	-0.9	-0.6	-0.6	-0.7	-0.7
Fasting Glucose	0.5	0.5	1.9	-1.4	-0.4	-0.2	-0.6	0.2	0.2	-0.0	-1.1	-1.1	-0.8	-0.5
HbA1C	0.3	0.4	0.7	-0.7	-0.7	-0.2	-0.4	0.7	-0.6	-0.8	-0.7	-0.7	-0.3	0.5
HDL Cholesterol	0.1	0.1	1.0	0.1	0.1	0.4	0.0	-0.4	0.2	1.0	-0.1	0.2	0.0	0.0
LDL Cholesterol	0.1	0.1	0.4	0.7	0.3	0.5	0.2	0.3	0.4	0.2	0.4	0.5	0.0	0.0
Lupus	0.3	0.4	1.1	-0.5	-0.3	-0.7	-1.0	1.0	-0.1	-0.8	-0.3	-0.7	-0.6	-0.6
Neuroticism (2016)	0.2	0.3	1.3	0.3	-0.3	-1.1	0.0	-0.1	-0.4	1.1	-0.0	-0.5	-0.4	0.1
Primary Biliary Cirrhosis	0.9	1.3	3.6	0.9	1.0	-0.1	1.0	-1.7	1.1	1.9	1.0	1.2	1.0	0.9
Rheumatoid Arthritis	0.2	0.3	1.3	-1.1	-0.2	0.2	0.4	-0.5	-0.1	-0.1	-0.2	-0.5	-0.3	-1.1
Schizophrenia (2014)	10.9	24.0	30.3	5.5	5.1	4.8	5.3	-5.1	5.2	-0.6	5.2	5.1	5.1	4.9
Triglycerides	0.4	0.7	1.4	-0.6	-0.9	-1.2	-0.7	0.7	-0.8	-1.1	-0.7	-1.2	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	2.0	-0.4	0.3	0.1	0.3	0.3	0.2	-1.4	0.3	0.1	0.0	0.0
Ulcerative Colitis	0.3	0.4	1.9	0.2	0.2	0.4	0.8	-1.0	0.2	-1.4	0.5	0.3	0.3	0.7
Blood Eosinophil Count	1.6	12.4	23.5	2.7	4.1	-0.3	4.0	-4.8	3.9	2.6	3.9	3.9	4.0	1.9
Blood Platelet Count	1.2	14.5	33.5	3.2	4.0	5.8	3.4	-2.3	4.1	3.7	4.1	4.2	4.2	0.6
Blood Red Count	0.1	1.0	2.9	1.7	0.9	0.9	1.1	-1.1	0.8	-0.1	1.0	0.9	0.8	0.9
Blood White Count	2.7	20.0	27.7	5.3	5.2	2.9	5.0	-4.4	5.1	0.1	4.6	5.0	5.0	4.0
Heel T-Score	0.4	3.3	21.2	-2.9	-0.4	-1.5	-0.6	-1.1	-0.5	-0.0	0.1	-1.3	-1.0	-4.6
BMI	0.3	1.6	9.7	1.0	-0.6	-2.0	0.1	1.3	-0.8	0.1	-0.7	0.1	-0.2	3.1
Height	0.2	3.0	8.9	1.3	1.2	0.6	0.8	-1.4	1.1	3.0	1.8	2.2	1.9	2.2
Waist Hip Ratio (WHR)	0.2	1.0	2.8	-0.1	1.1	1.2	1.4	-1.7	1.0	-0.4	0.7	0.3	0.6	-1.0
Systolic Blood Pressure	1.8	9.0	16.2	2.5	2.9	2.3	3.1	-3.3	2.8	-4.0	2.7	2.6	2.8	3.5
Smoking Status	0.4	1.0	6.5	0.1	0.3	1.6	-0.1	0.9	0.7	0.4	-0.3	0.1	0.1	-2.5
Allergy or Eczema	0.2	0.5	3.4	-0.2	-0.2	-1.9	0.0	-1.0	-0.4	-0.4	-0.1	-0.5	-0.4	0.5
Cardiovascular Disease	0.3	1.1	3.0	1.3	0.8	0.7	1.3	-0.9	0.8	-1.2	0.2	1.0	0.8	1.7
Hypothyroidism (self reported)	0.1	0.2	1.8	-0.1	-0.1	1.4	-0.3	0.0	0.2	-0.7	0.3	0.2	0.1	-0.2
Respiratory disease	0.5	1.2	6.1	-0.4	-0.8	-2.5	-0.3	-0.5	-0.9	1.3	-0.8	-1.0	-0.9	0.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.2	-0.5	-1.1	-1.0	-0.6	0.5	-1.0	0.1	-1.3	-1.5	-1.4	1.1
Lung FEV1/FVC ratio	1.2	6.2	11.1	2.8	2.5	0.7	2.8	-1.7	2.2	-2.4	2.2	3.0	2.7	3.3
Lung FVC	0.2	1.2	9.6	-1.5	-0.3	0.8	-0.4	-0.4	-0.2	0.6	-0.2	-0.2	-0.2	-3.1
Neuroticism	0.9	2.2	8.6	1.5	1.1	-0.9	1.2	-1.3	1.0	2.9	1.5	1.2	1.0	1.6
Chronotype (morning person)	0.8	1.9	9.7	0.4	-0.6	-2.4	-0.6	0.6	-1.0	-1.6	-0.4	-0.5	-0.5	3.1
Hair Pigment	0.0	1.0	6.5	-0.7	-0.1	2.5	-0.3	0.5	0.1	-0.2	-0.3	-0.5	-0.3	-1.7
Tanning	0.1	0.9	2.4	0.5	0.7	1.6	0.7	-0.7	0.8	1.0	0.7	1.4	1.2	-0.4
Hand grip strength (left)	1.8	4.8	19.4	4.0	1.2	2.1	1.2	-0.1	1.2	0.3	1.2	2.0	1.8	4.4
Number of treatments/medications taken	0.4	0.8	2.5	0.2	-0.9	-1.6	-1.0	0.8	-0.7	0.5	-0.6	-0.6	-0.7	1.3
Average weekly spirits intake	5.5	6.8	10.1	-2.5	-2.9	-0.2	-2.8	2.6	-2.7	-1.1	-3.2	-3.1	-3.1	-2.7
Sensitivity / hurt feelings	0.1	0.2	0.9	0.0	0.5	-0.1	0.6	-1.0	0.4	0.4	0.8	0.2	0.1	-0.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.0	1.6	1.3	0.2	1.6	-1.7	1.3	1.0	1.5	2.0	1.6	1.5
Hearing difficulty/problems: Yes	0.8	1.2	4.4	-1.3	-0.9	-0.0	-1.0	0.8	-0.8	-0.6	-1.1	-1.2	-1.0	-2.1
Relative age of first facial hair	0.6	1.1	5.0	-0.9	-0.6	-1.7	-0.6	0.6	-0.7	2.2	-0.8	-0.7	-0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.9	0.3	1.0	0.2	0.7	-0.7	1.1	2.0	1.2	0.6	0.7	-0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.5	0.1	-1.3	-1.4	-1.6	1.1	-1.2	1.3	-1.2	-0.8	-0.9	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	1.1	0.2	-0.4	-1.0	-0.2	0.1	-0.4	0.8	-0.5	-0.2	-0.3	0.0
Systolic blood pressure, automated reading	1.6	4.7	12.2	1.6	1.9	2.2	2.1	-2.1	1.9	-2.7	1.5	1.9	1.9	3.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.3	0.2	-0.7	-0.9	-0.4	0.3	-0.7	1.5	-0.8	-0.6	-0.6	1.4
Angina	1.3	1.7	3.2	1.3	1.2	0.9	1.3	-1.6	1.2	1.0	1.4	1.2	1.2	1.8
Medication for hormone replacement therapy	0.6	0.6	3.4	0.9	0.5	1.8	0.2	-0.0	0.7	0.1	0.4	0.7	0.8	0.9
Vitamin and mineral supplements	0.6	0.8	1.7	1.0	0.9	1.3	0.9	-0.5	0.8	-1.1	0.7	1.1	1.0	0.4
Supplements: Zinc	0.9	1.0	4.7	-0.8	-0.7	-2.2	-0.4	0.4	-0.6	-1.7	-1.0	-0.3	-0.5	-0.4
Medication: Co-codamol	0.8	0.9	2.2	0.7	0.9	1.0	1.5	-1.3	0.9	0.3	1.1	0.9	1.0	-0.4
Medication: Metformin	0.5	0.7	1.9	-0.6	-0.9	-0.2	-0.7	0.7	-0.9	-0.3	-1.1	-1.4	-1.2	-0.1
Diabetes (father)	1.2	1.5	2.6	1.5	1.4	0.0	1.5	-0.9	1.3	-0.3	1.4	1.2	1.4	1.6
Diabetes (mother)	3.8	4.8	7.7	1.4	2.3	2.6	2.8	-2.5	2.4	-1.3	1.9	2.6	2.4	0.9
Severe depression (siblings)	3.3	3.6	5.6	1.7	2.2	1.6	1.9	-1.9	2.1	0.6	2.1	2.4	2.3	1.5
Pack years adult smoking proportion	0.9	1.4	2.8	0.4	1.3	1.2	1.4	-1.4	1.4	-0.2	1.1	1.7	1.5	0.2
Impedance of leg (right)	0.2	0.9	4.1	-1.7	-0.1	-0.5	-0.2	-1.3	-0.1	0.8	0.2	-0.6	-0.6	-2.0
Leg fat-free mass (left)	0.2	1.3	8.9	1.7	0.1	-1.0	0.4	0.4	-0.1	0.2	-0.0	0.7	0.6	3.0
Trunk fat percentage	0.7	3.0	14.0	-1.0	-1.6	-3.7	-1.3	1.3	-1.8	1.0	-1.7	-1.3	-1.5	0.6
Hand grip strength (right)	2.1	5.6	15.6	3.7	1.7	3.0	2.0	-0.7	1.7	-0.4	1.5	2.4	2.2	3.9
Townsend deprivation index at recruitment	0.3	0.4	2.6	-0.1	0.4	0.4	0.5	0.0	0.5	-0.9	0.1	0.4	0.5	-1.6
Current tobacco smoking	0.5	0.8	3.0	0.8	0.5	1.7	0.3	0.5	0.6	-1.6	-0.2	0.6	0.5	-1.0
Average weekly fortified wine intake	0.9	1.0	5.7	-1.5	-0.5	-1.0	-0.6	-0.0	-0.7	-0.6	-0.6	-0.7	-0.6	-2.4
Maternal smoking around birth	1.4	2.0	5.6	2.4	1.2	2.3	0.8	0.1	1.3	1.0	1.3	1.2	1.3	1.2
Fed-up feelings	0.3	0.6	3.2	-0.0	-0.1	-1.8	0.2	-0.4	-0.3	1.4	-0.1	0.3	0.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.5	7.2	2.7	2.3	0.2	2.6	-2.0	2.4	0.4	2.0	2.6	2.4	2.0
Relative age voice broke	0.3	0.4	1.0	0.1	0.8	0.4	0.5	-0.9	0.7	1.0	0.5	0.6	0.7	0.3
Taking other prescription medications	1.1	1.7	6.6	-0.4	-1.3	-2.6	-1.3	0.7	-1.2	1.8	-1.1	-1.1	-1.2	0.1
Age when periods started (menarche)	0.8	1.9	4.8	0.8	1.6	2.2	1.0	-0.8	1.7	0.3	1.6	1.6	1.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.7	0.3	0.2	0.8	-0.7	0.4	0.1	0.4	0.4	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	6.2	-1.7	-0.6	-1.1	-1.0	0.7	-0.8	-0.9	-0.4	-1.0	-0.8	-2.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	0.7	1.5	1.2	0.7	-0.8	1.5	0.6	1.4	1.4	1.5	0.8
Qualifications: CSEs or equivalent	0.3	0.4	2.7	0.7	0.0	-0.7	0.0	-0.3	0.1	-0.1	-0.2	0.2	0.2	1.7
Serious illness, injury or assault to yourself	1.1	1.4	6.7	-0.6	-1.0	-2.6	-1.1	0.6	-1.1	0.5	-0.7	-1.3	-1.1	-0.3
High blood pressure	1.1	3.0	7.3	1.4	1.6	1.4	1.8	-1.5	1.6	-2.7	1.0	1.5	1.7	2.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	5.7	-0.5	-1.0	-2.4	-0.8	-0.0	-1.0	-0.3	-1.0	-1.3	-1.2	0.3
Multivitamins +/- minerals	0.2	0.3	0.6	-0.6	-0.6	-0.5	-0.7	0.8	-0.4	-0.3	-0.5	-0.6	-0.6	0.2
Stomach or abdominal pain in last month	5.0	6.2	10.3	2.8	2.5	2.4	2.5	-1.8	2.6	0.7	3.2	3.0	2.8	2.2
Supplements: Glucosamine	2.0	2.6	6.0	-1.9	-1.6	-1.1	-1.3	1.4	-1.5	0.1	-1.6	-1.7	-1.8	-2.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.3	-0.6	-0.4	-0.6	0.9	-0.6	0.6	-0.1	-0.4	-0.4	0.4
Medication: Atenolol	0.3	0.3	1.9	0.7	0.1	1.4	0.1	0.3	0.1	-0.3	0.5	-0.1	-0.0	0.9
Medication: Levothyroxine sodium	0.3	0.4	1.2	0.3	0.6	0.5	0.2	-0.7	0.6	-1.1	1.0	0.7	0.5	0.1
Sitting height	0.0	0.3	0.9	0.4	-0.2	0.6	-0.6	0.7	-0.2	0.9	0.1	0.6	0.4	1.0
Chronic bronchitis/emphysema (father)	0.8	0.9	3.9	1.2	-0.5	0.4	-0.3	0.7	-0.2	1.8	-0.2	-0.2	-0.4	2.0
High blood pressure (mother)	1.9	2.6	5.6	1.9	1.5	1.6	2.0	-1.3	1.5	-0.7	1.3	1.6	1.6	2.4
Body mass index (BMI)	0.3	1.3	7.9	1.1	-0.4	-1.8	0.0	1.1	-0.5	0.0	-0.6	0.1	0.0	2.8
Impedance of leg (left)	0.1	0.5	1.9	-1.0	0.4	-0.0	0.1	-1.4	0.4	0.8	0.6	0.1	0.0	-1.2
Leg predicted mass (left)	0.2	1.3	8.9	1.6	0.0	-1.0	0.3	0.5	-0.1	0.2	-0.1	0.6	0.6	3.0
Trunk fat mass	0.4	1.9	9.6	-0.2	-1.2	-3.1	-0.9	1.2	-1.3	0.8	-1.2	-0.6	-0.9	1.5
Waist circumference	0.1	0.5	2.9	0.6	-0.1	-1.1	0.6	-0.0	-0.1	0.4	-0.3	0.2	0.1	1.7
Number of incorrect matches in round	0.5	0.8	3.0	0.4	-0.8	-1.7	-0.4	0.3	-0.9	0.7	-0.2	-0.4	-0.5	1.6
Past tobacco smoking	0.7	1.2	7.3	1.1	-0.1	0.3	0.2	0.0	-0.2	-2.1	-0.3	0.4	0.2	2.7
Alcohol usually taken with meals	0.2	0.4	1.3	0.6	-0.7	-0.2	-0.7	1.2	-0.7	-0.3	-0.3	0.0	-0.3	0.9
Nervous feelings	1.2	2.2	6.5	0.5	1.7	0.4	1.9	-2.5	1.5	-0.9	2.1	1.1	1.2	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.4	0.3	0.8	0.2	1.2	-1.5	0.7	0.6	1.1	1.1	1.0	-0.1
Hearing difficulty/problems with background noise	0.6	0.9	2.2	-1.5	-0.5	-0.0	-0.9	0.8	-0.4	-1.4	-0.7	-1.0	-0.8	-1.5
Hair/balding pattern: Pattern 2	3.4	4.3	6.8	2.6	2.1	2.0	2.2	-1.6	2.1	0.2	2.3	2.0	2.1	2.4
Had menopause	3.5	4.3	6.9	-1.9	-2.5	-1.8	-2.1	1.6	-2.5	-0.2	-2.6	-2.3	-2.4	-1.7
Had other major operations	3.2	3.9	7.7	-1.8	-1.7	-1.4	-1.9	2.2	-1.6	2.1	-1.8	-2.1	-2.0	-2.8
Forced vital capacity (FVC)	0.1	0.3	1.4	-0.6	-0.1	-0.0	-0.4	-0.6	-0.1	1.2	0.0	0.2	0.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	3.1	-0.9	-0.1	-0.5	-0.4	0.0	-0.1	-0.2	0.5	-0.4	-0.1	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	0.6	0.7	-0.2	0.7	-0.9	0.9	1.2	0.8	1.2	1.0	0.5
Qualifications: None of the above	0.2	0.4	1.3	-0.5	-0.5	-0.0	-0.2	0.6	-0.4	-1.1	-0.5	-0.7	-0.6	0.7
Financial difficulties in last 2 years	0.6	0.8	2.0	0.4	0.9	0.6	1.3	-1.4	1.0	-1.2	0.4	0.9	0.7	-0.4
Mouth/teeth dental problems	0.7	1.1	2.3	-0.5	-1.2	0.1	-1.4	1.1	-1.2	-0.1	-1.2	-1.5	-1.5	-0.4
Heart attack	0.3	0.3	1.7	0.9	0.3	0.1	-0.2	0.0	0.2	0.8	0.6	0.4	0.4	1.3
Allergy	0.8	1.9	9.4	0.5	1.2	3.1	1.2	-0.2	1.3	-1.1	1.2	1.4	1.3	-0.8
Pain all over the body in last month	0.5	0.6	1.0	-0.6	-0.9	-0.3	-0.9	1.0	-0.7	0.1	-0.9	-1.0	-0.9	-0.5
Diabetes (self-reported)	0.6	0.9	2.4	-0.7	-1.1	-0.7	-0.8	0.5	-1.0	-0.0	-1.2	-1.5	-1.5	0.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.9	0.8	1.1	0.3	1.3	-1.7	1.2	-0.2	1.1	0.8	0.9	1.0
Medication: Ramipril	0.3	0.4	2.9	0.3	0.0	-0.2	0.6	-0.7	-0.0	-1.7	-0.1	-0.0	0.0	0.8
Medication: Simvastatin	0.3	0.4	1.0	0.7	-0.6	0.6	-0.5	0.8	-0.5	0.9	-0.4	-0.4	-0.6	1.0
Fluid intelligence score	1.5	3.1	11.8	-1.8	-1.7	-0.6	-1.6	1.6	-1.7	0.4	-1.5	-1.7	-1.7	-3.4
Illnesses of siblings	1.2	1.7	3.4	-0.7	-1.3	-1.9	-1.8	1.8	-1.2	0.6	-1.3	-1.0	-1.2	-1.0
Neuroticism score	1.3	2.6	4.0	1.8	1.5	-0.9	1.6	-1.8	1.3	2.0	1.9	1.6	1.5	1.7
Weight	0.3	1.4	9.4	1.3	-0.2	-1.6	0.1	0.7	-0.3	0.4	-0.2	0.6	0.4	3.1
Impedance of arm (right)	0.8	3.7	13.8	-3.1	-1.0	-2.1	-1.1	-0.8	-1.0	1.4	-0.9	-1.9	-1.7	-3.7
Arm fat percentage (right)	0.4	1.7	8.9	-0.5	-1.1	-3.0	-0.8	1.2	-1.1	0.8	-1.2	-0.8	-0.9	1.1
Trunk fat-free mass	1.1	6.5	26.1	3.6	1.9	1.7	1.8	-0.8	1.8	0.6	2.1	2.8	2.7	5.1
Hip circumference	0.3	1.1	4.2	0.7	-0.7	-2.1	-0.2	0.9	-0.7	1.1	-0.7	0.0	-0.3	1.9
Time employed in main current job	0.8	1.0	1.8	0.7	1.0	0.8	1.3	-1.3	1.0	-0.9	1.0	0.8	0.9	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.5	0.7	0.8	-0.6	0.9	-1.0	0.7	1.2	0.8	0.9	0.9	1.1
Father’s age at death	0.2	0.3	1.5	-0.2	0.2	0.7	0.2	-0.3	0.3	-1.2	0.0	0.1	-0.0	-1.0
Worrier / anxious feelings	0.7	1.2	2.7	1.2	0.9	-0.7	1.2	-1.4	0.8	1.1	1.2	0.9	0.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.9	1.2	0.5	-2.0	0.8	-0.9	0.4	1.5	0.8	1.0	0.8	2.2
Falls in the last year	0.1	0.2	1.2	-0.1	-0.1	-1.1	-0.1	-0.5	-0.1	-0.3	-0.1	-0.1	-0.1	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.9	0.1	0.1	1.0	0.0	0.3	0.1	0.4	0.1	-0.2	-0.1	-0.1
Number of live births	0.3	0.4	1.9	0.2	-0.8	-0.1	-0.5	0.3	-0.6	1.4	-0.7	-0.5	-0.7	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	0.2	0.6	0.2	0.4	-1.0	0.5	0.3	0.7	1.0	0.8	0.3
Pulse rate	0.7	1.2	2.1	1.3	1.3	0.5	1.1	-0.7	1.2	0.2	1.2	1.5	1.4	0.7
Happiness	4.1	4.9	6.9	2.4	2.3	0.9	2.3	-2.5	2.2	2.1	2.4	2.2	2.1	2.6
Noisy workplace	0.5	0.6	3.9	0.3	0.5	0.1	-0.2	0.2	0.5	1.2	0.4	0.5	0.5	2.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	7.4	-1.0	-0.0	0.1	-0.0	-0.1	-0.1	-0.9	-0.4	-0.0	-0.2	-2.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.0	1.0	0.7	2.0	0.5	-0.4	0.8	0.9	1.3	0.6	0.6	0.0
Mouth/teeth dental problems: Dentures	0.8	1.3	2.9	0.8	1.1	1.7	1.0	-0.9	1.3	0.9	1.1	1.4	1.3	1.0
Asthma	0.2	0.4	1.9	-0.3	-0.2	-1.4	0.1	-0.4	-0.3	1.3	-0.4	-0.5	-0.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	0.7	0.5	0.1	0.2	-0.6	0.4	1.2	0.7	0.5	0.6	0.7
Medication: Cholesterol lowering	0.4	0.7	2.4	0.6	-0.6	-0.5	-0.8	0.8	-0.6	1.1	-0.6	-0.5	-0.6	1.6
Depression (self-reported)	0.6	0.8	5.4	0.3	-0.7	-2.3	-0.4	0.6	-0.7	-0.7	-0.2	-0.1	-0.5	0.9
Medication: Lansoprazole	0.9	1.0	2.8	0.9	0.8	0.3	1.2	-1.7	0.8	0.5	1.0	1.0	0.8	1.2
Prospective memory result	0.8	1.0	2.1	-1.4	-1.1	-1.4	-0.6	0.3	-1.1	-0.7	-1.4	-0.9	-1.0	0.5
Lung cancer (father)	0.3	0.3	1.3	-1.0	0.1	0.7	0.4	-0.6	0.2	0.5	0.1	0.0	-0.0	-1.1
Illnesses of mother	0.4	0.5	1.9	-0.9	-0.0	0.9	-0.6	0.7	0.1	-1.1	0.1	-0.4	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.8	0.3	1.0	0.7	0.7	-1.3	0.9	0.2	1.1	1.4	1.2	0.2
Pulse wave Arterial Stiffness index	1.0	1.2	3.0	0.2	-1.1	-0.7	-1.3	0.9	-1.0	1.4	-1.1	-0.7	-1.0	1.7
Impedance of arm (left)	1.4	6.4	15.3	-3.6	-2.0	-3.1	-2.0	0.1	-2.1	1.7	-1.9	-2.7	-2.6	-3.9
Arm fat mass (right)	0.3	1.3	5.4	0.4	-0.7	-2.3	-0.4	1.0	-0.8	0.7	-0.7	-0.2	-0.3	2.3
Trunk predicted mass	1.2	6.6	26.2	3.6	1.9	1.7	1.8	-0.8	1.8	0.7	2.1	2.8	2.7	5.1
Standing height	0.1	1.3	2.6	1.1	0.9	0.7	0.6	-1.1	0.8	1.5	1.2	1.6	1.3	1.5
Length of working week for main job	0.1	0.1	0.7	-0.1	0.1	0.3	-0.2	0.2	0.1	0.8	0.0	-0.1	0.1	0.4
Exposure to tobacco smoke at home	1.4	1.6	2.6	1.4	1.2	1.4	1.6	-1.2	1.2	-0.8	1.4	1.4	1.3	0.8
Breastfed as a baby	1.1	1.4	4.3	-2.1	-0.7	-1.7	-0.9	-0.5	-0.6	0.1	-1.0	-1.0	-0.9	-1.7
Tense / ‘highly strung’	1.1	1.7	5.4	-0.8	-1.2	-2.3	-1.3	0.8	-1.4	2.3	-0.6	-0.8	-1.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.8	0.6	0.8	0.4	0.5	-0.4	0.9	-0.1	1.3	0.8	0.8	0.3
Hair/balding pattern: Pattern 4	1.5	3.6	6.8	-2.2	-1.9	-1.8	-1.1	0.8	-1.8	-2.4	-2.2	-1.5	-1.9	-2.6
Birth weight of first child	0.9	1.6	9.3	2.5	0.2	0.2	0.5	0.2	0.0	0.7	0.6	0.7	0.6	3.1
Peak expiratory flow (PEF)	0.5	1.1	3.3	1.3	0.9	-0.4	0.5	-0.6	0.8	-0.9	0.7	1.3	1.1	1.8
Pulse wave reflection index	1.0	1.3	2.3	-0.6	-1.4	-0.3	-1.5	1.3	-1.4	0.5	-1.1	-1.2	-1.4	0.9
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.2	0.3	0.1	0.1	-0.3	0.3	0.5	0.6	0.7	0.6	0.4
Loud music exposure frequency	1.1	1.2	3.3	0.0	1.2	-0.7	1.3	-1.8	1.1	0.4	1.3	1.0	1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.4	-0.2	-0.1	-0.3	-0.5	0.4	-0.1	1.1	-0.0	-0.1	-0.1	-1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	0.9	0.3	-1.1	0.3	-0.0	0.2	0.9	0.5	0.6	0.5	1.3
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.4	-1.0	-0.5	-1.1	1.6	-1.0	0.8	-0.6	-0.9	-0.8	1.0
Medication: Paracetamol	1.9	3.2	8.3	2.3	1.5	1.2	1.2	-0.9	1.7	1.6	1.6	1.9	1.9	2.9
Headache pain in last month	0.4	0.7	3.6	0.6	0.2	-0.0	0.3	-0.4	0.3	1.3	0.6	0.7	0.6	1.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.3	0.7	1.3	0.6	-0.9	0.7	0.5	0.8	0.5	0.6	-1.0
Glaucoma (self-reported)	0.3	0.4	1.2	-0.7	0.3	-0.3	0.6	-0.8	0.4	-1.1	0.2	-0.1	0.1	-0.9
Gout (self-reported)	0.2	0.3	1.0	0.1	0.5	0.1	0.3	-0.6	0.5	1.0	0.5	0.5	0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.4	-0.7	0.1	-0.9	0.5	-0.5	-0.1	-0.2	-0.3	-0.5	-0.3
Medication: Amlodipine	0.1	0.2	0.9	0.4	0.5	0.2	0.1	0.2	0.5	-0.9	0.2	0.3	0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	3.2	-0.5	-0.1	-1.8	-0.0	-0.3	-0.3	-0.7	-0.2	-0.2	-0.1	-0.5
Birth weight	0.3	0.6	2.6	1.3	-0.3	0.3	0.1	0.4	-0.2	1.2	0.2	0.4	0.4	1.6
Chronic bronchitis/emphysema (mother)	1.8	2.1	5.6	-0.6	-1.5	-0.8	-1.8	1.8	-1.5	2.4	-1.3	-1.4	-1.4	-0.2
High blood pressure (siblings)	0.9	1.3	2.8	1.2	1.1	1.0	1.3	-0.8	1.0	-0.9	1.3	0.9	1.1	1.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.5	-0.2	0.7	0.8	0.4	-1.2	0.7	0.7	0.8	1.0	0.8	-1.0
Body fat percentage	0.6	2.4	12.5	-0.8	-1.4	-3.5	-1.0	1.3	-1.5	0.6	-1.5	-1.0	-1.2	0.8
Leg fat percentage (right)	0.5	1.7	7.1	-0.6	-1.3	-2.7	-0.7	1.3	-1.4	-0.1	-1.4	-1.1	-1.2	0.8
Arm fat-free mass (right)	0.6	3.0	20.4	2.7	0.5	0.0	0.6	0.5	0.4	0.3	0.7	1.5	1.3	4.5
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.1	0.7	-0.2	0.7	-0.8	0.6	-0.8	0.8	0.7	0.5	-0.4
Comparative body size at age 10	2.4	6.6	13.8	3.7	2.3	2.0	2.5	-0.8	2.2	-2.6	1.9	2.9	2.7	3.5
Number of full brothers	0.4	0.5	1.9	-0.8	-0.4	-0.6	-0.3	-0.4	-0.4	0.8	-0.5	-0.6	-0.6	-1.4
Worry too long after embarrassment	1.3	2.2	4.2	1.3	1.8	0.9	1.4	-1.9	1.9	0.8	2.1	1.4	1.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	0.6	0.7	0.0	0.8	-0.8	0.8	-0.6	0.9	0.7	0.7	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.3	0.2	-0.5	0.4	-0.7	0.3	0.5	0.3	0.2	0.2	0.4
Number of children fathered	1.7	1.9	9.6	1.0	1.1	3.1	1.2	-0.3	1.3	-0.5	1.3	1.1	1.0	1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.2	1.7	1.6	1.8	1.4	-1.5	1.6	0.8	1.5	1.5	1.6	1.3
Age at first live birth	0.7	1.3	3.6	-1.2	-1.0	-0.4	-1.1	1.3	-1.0	0.3	-1.3	-1.2	-1.0	-1.9
Pulse wave peak to peak time	1.0	1.2	2.5	-0.0	1.2	0.6	1.4	-1.0	1.1	-1.3	1.2	0.8	1.1	-1.6
Health satisfaction	2.5	3.2	5.0	1.7	1.9	1.7	1.7	-1.4	2.0	1.5	2.2	1.7	1.7	2.0
Shortness of breath walking on level ground	1.0	1.2	2.2	0.1	1.2	0.0	1.0	-1.5	1.3	0.8	1.2	1.3	1.3	0.8
Qualifications: College or University degree	0.8	2.6	15.0	-2.2	-1.0	-0.6	-0.8	0.6	-1.1	-0.9	-1.4	-1.1	-1.2	-3.9
Eye problems/disorders: None of the above	2.1	2.5	3.5	1.2	1.8	1.8	1.5	-1.9	1.8	-0.3	1.7	1.7	1.8	1.0
Mouth/teeth dental problems: Loose teeth	5.2	6.2	9.7	2.1	2.8	2.7	3.1	-2.6	3.0	1.3	2.6	2.7	2.7	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.3	-0.5	-0.6	-0.7	0.7	-0.4	0.0	-0.1	-0.5	-0.5	-0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	6.0	-1.5	-0.8	-0.7	-0.2	0.2	-0.9	-1.2	-1.2	-1.0	-1.1	-2.4
Neck or shoulder pain in last month	0.7	1.0	9.3	0.2	-0.0	0.3	-0.3	0.4	0.1	3.1	0.7	0.5	0.5	0.0
Medication: Blood pressure	0.2	0.4	2.3	-0.1	-0.2	-1.0	-0.2	0.3	-0.3	-1.5	-0.3	-0.3	-0.2	0.7
Angina (self-reported)	1.4	1.8	3.4	1.3	1.2	1.0	1.4	-1.8	1.3	0.6	1.5	1.2	1.2	1.8
Migraine (self-reported)	0.2	0.3	1.1	-0.1	-0.4	-0.9	-0.4	0.1	-0.4	0.6	-0.4	0.4	0.1	1.0
Medication: Ibuprofen	0.2	0.3	1.7	0.3	0.2	-0.2	-0.0	-0.6	0.1	1.3	0.4	0.3	0.4	0.5
Medication: Allopurinol	0.5	0.6	2.1	-1.4	-0.7	-1.0	-0.8	0.1	-0.7	0.2	-0.7	-0.9	-0.8	-0.4
Medication: Omeprazole	0.4	0.5	1.4	0.8	0.8	0.0	0.8	-0.7	0.8	0.8	1.2	0.4	0.5	0.1
Medication: Seretide 50 evohaler	0.8	0.9	1.5	0.6	1.2	-0.0	0.9	-0.9	0.9	1.0	1.2	1.0	1.0	0.9
Mean time to correctly identify matches	1.1	2.1	9.6	-2.8	-0.6	-0.3	-0.9	0.2	-0.9	-0.9	-0.1	-1.2	-1.0	-3.1
Heart disease (mother)	0.6	0.8	3.7	1.2	-0.2	-1.2	0.1	-0.2	-0.3	1.9	-0.3	0.2	-0.0	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	3.4	0.8	1.7	1.5	1.8	-1.6	1.8	-1.0	1.6	1.4	1.4	1.0
Whole body fat mass	0.3	1.3	6.8	0.1	-0.8	-2.6	-0.5	1.0	-0.9	0.5	-0.9	-0.3	-0.5	1.8
Leg fat mass (right)	0.3	1.4	6.2	0.2	-0.9	-2.5	-0.4	1.2	-1.0	-0.2	-1.0	-0.4	-0.6	1.9
Arm predicted mass (right)	0.9	4.4	24.0	3.3	1.0	0.7	1.2	0.1	1.0	0.4	1.2	2.1	1.9	4.9
Pulse rate, automated reading	1.3	4.2	7.6	1.1	2.5	1.5	2.6	-2.1	2.3	-0.6	2.1	2.7	2.8	0.6
Alcohol intake frequency.	0.4	0.9	5.2	-0.2	-0.9	-2.3	-0.2	-0.1	-0.9	-0.4	-0.4	-0.6	-0.7	1.4
Comparative height size at age 10	0.1	0.4	1.0	-1.0	-0.8	0.4	-0.7	0.5	-0.8	-0.0	-0.3	-0.3	-0.7	-0.2
Number of full sisters	1.1	1.3	2.4	1.2	1.1	1.2	0.8	-0.9	1.3	-0.5	1.1	1.3	1.2	1.6
Suffer from ‘nerves’	0.8	1.2	2.3	1.2	1.0	0.8	1.3	-1.4	1.0	-0.5	1.5	1.2	1.1	0.9
Overall health rating	1.7	3.7	7.7	2.0	2.0	0.3	2.0	-1.7	1.9	1.1	2.5	1.8	1.9	2.8
Chest pain or discomfort	2.6	3.7	6.1	1.6	2.0	1.0	1.9	-2.3	2.1	1.4	2.5	2.0	1.9	2.0
Had major operations	0.1	0.1	0.4	-0.4	0.0	-0.4	-0.2	-0.7	0.3	-0.4	0.0	0.2	0.1	-0.5
Age at last live birth	0.4	0.5	3.1	-0.7	-0.4	-0.1	-0.5	0.7	-0.4	-0.4	-0.8	-0.7	-0.4	-1.8
Family relationship satisfaction	2.4	3.0	4.7	1.9	1.8	0.5	1.5	-1.5	1.6	2.2	2.0	1.6	1.7	2.1
Leg pain on walking	0.7	0.8	1.4	1.2	1.0	0.8	1.1	-0.5	1.1	-0.1	0.9	1.1	1.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	4.2	0.9	0.5	0.9	0.4	-0.1	0.5	-2.1	1.0	0.2	0.4	1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.5	0.5	0.8	0.8	1.1	-1.1	0.9	-1.1	1.1	1.1	1.0	1.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.9	-1.5	-0.9	-0.6	-1.1	1.7	-1.0	-0.9	-1.2	-1.0	-1.0	-1.4
Medication: Aspirin	0.2	0.3	0.9	-0.0	-0.3	0.9	-0.6	1.0	-0.1	-0.4	-0.2	-0.4	-0.3	0.3
Supplements: Vitamin C	0.3	0.4	1.6	-1.0	-0.3	-0.5	-0.3	0.1	-0.2	1.3	-0.4	-0.3	-0.3	-0.6
Knee pain experienced in last month	0.3	0.4	2.1	0.2	-0.7	-0.9	-0.2	0.6	-0.5	1.4	-0.3	-0.5	-0.4	0.4
Hypertension (Self-reported)	0.8	2.1	5.6	1.2	1.3	0.6	1.6	-1.3	1.3	-2.4	0.7	1.3	1.4	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.2	-0.6	-0.5	-0.8	0.4	-0.6	0.6	-0.3	-0.9	-0.8	-0.1
Illnesses of father: Heart disease	0.4	0.5	1.5	0.8	0.3	0.6	0.6	-0.9	0.4	1.2	0.4	0.3	0.3	1.2
Illnesses of siblings: Diabetes	0.3	0.4	1.4	0.1	0.4	0.5	0.7	-0.6	0.3	1.2	0.5	0.4	0.3	0.8
Smoking status: Previous	1.0	1.5	5.0	-1.4	-0.7	-0.9	-0.9	0.5	-0.6	2.1	-0.3	-1.1	-0.9	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	1.0	0.6	0.0	0.6	-0.5	0.4	1.0	0.8	0.7	0.7	1.1
Whole body fat-free mass	0.6	3.7	20.0	3.0	1.0	0.5	1.1	-0.1	0.9	0.5	1.2	1.9	1.8	4.5
Leg fat-free mass (right)	0.3	1.7	11.2	2.1	0.3	-0.6	0.6	0.4	0.2	0.2	0.2	1.1	1.0	3.4
Arm fat percentage (left)	0.6	2.6	12.1	-0.7	-1.5	-3.5	-1.1	1.5	-1.6	0.6	-1.6	-1.2	-1.3	1.0
Average weekly red wine intake	1.2	1.8	3.9	-0.6	-1.6	0.0	-1.7	2.0	-1.4	0.5	-1.5	-1.3	-1.5	-1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	0.5	0.5	0.8	0.7	-0.7	0.6	-0.4	0.1	0.4	0.5	0.1
Mood swings	0.7	1.2	4.0	1.4	0.5	-2.0	0.7	-0.9	0.4	1.0	0.5	0.6	0.6	2.0
Loneliness, isolation	0.7	1.0	5.5	-0.5	-1.0	-2.4	-0.4	0.1	-1.0	1.2	-1.0	-0.5	-0.8	0.1
Long-standing illness, disability or infirmity	0.4	0.6	2.8	1.2	0.2	-0.8	0.2	-0.2	0.2	0.6	0.9	0.2	0.2	1.7
Ever had bowel cancer screening	0.2	0.2	0.9	0.1	-0.2	-0.0	0.1	0.5	-0.1	0.9	-0.2	-0.0	-0.1	0.8
Diabetes diagnosed by doctor	0.6	1.0	2.7	-0.9	-1.1	-0.9	-0.8	0.6	-1.0	0.1	-1.1	-1.6	-1.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.8	0.0	0.0	0.1	0.3	0.5	-0.1	0.6	-0.3	-0.5	-0.3	-1.4
Friendships satisfaction	6.7	8.3	10.7	3.1	3.1	1.8	3.3	-3.1	3.1	0.5	3.3	3.0	2.9	3.2
Qualifications: nursing, teaching	3.4	5.3	7.8	-2.4	-2.6	-1.4	-2.6	2.8	-2.6	-0.9	-2.5	-2.2	-2.4	-2.3
Commuting to job workplace: Walk	0.2	0.2	1.0	0.6	-0.3	0.9	0.2	0.0	-0.1	-0.0	-0.2	-0.4	-0.4	-1.0
Eye problems/disorders: Cataract	4.0	4.6	7.1	-2.3	-2.3	-2.0	-2.3	2.7	-2.2	-0.7	-2.3	-2.1	-2.2	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.6	-0.5	1.2	-0.0	1.2	-0.9	1.1	-2.1	1.3	0.9	1.1	-0.5
Medication for cholesterol	0.3	0.4	2.0	-0.1	-0.0	-1.4	0.3	-0.7	-0.1	1.3	0.1	-0.2	-0.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.8	0.9	1.0	1.3	1.3	-0.6	1.1	-0.2	1.1	1.1	1.2	1.2
Back pain experienced in last month	0.7	1.0	3.3	1.4	0.6	0.4	0.1	-0.2	0.6	1.8	1.1	0.9	0.8	1.3
Mineral and other dietary supplements	0.1	0.1	0.5	0.7	0.2	-0.4	0.3	-0.1	-0.1	-0.4	-0.0	0.4	0.3	0.1
Breast cancer (self-reported)	4.5	5.3	10.0	-2.6	-2.3	-1.5	-2.3	2.1	-2.3	-0.2	-2.3	-2.8	-2.5	-3.2
Asthma (self-reported)	0.3	0.5	3.0	-0.3	-0.3	-1.7	-0.1	-0.2	-0.5	1.1	-0.5	-0.7	-0.5	-0.1
Osteoporosis (self-reported)	0.8	1.0	5.7	1.8	0.4	-0.5	0.0	-0.2	0.3	0.5	0.8	0.7	0.7	2.4
Osteoarthritis (self-reported)	1.4	1.8	4.1	-2.0	-1.4	-1.5	-1.0	0.5	-1.2	0.9	-1.0	-1.7	-1.6	-1.0
Medication: Aspirin	0.3	0.3	1.8	0.4	0.4	1.4	-0.0	0.3	0.5	-0.5	0.3	0.2	0.3	0.8
Medication: Gliclazide	0.6	0.7	2.3	1.3	0.4	1.5	0.3	0.1	0.5	1.1	0.2	0.2	0.3	1.2
Illnesses of father: None of the above (group 1)	2.0	2.5	7.1	-2.0	-1.4	-0.6	-1.5	1.7	-1.6	-0.9	-1.4	-1.2	-1.3	-2.7
Smoking status: Current	0.5	0.8	2.4	0.9	0.7	1.5	0.6	0.2	0.8	-1.6	-0.1	0.8	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.8	-0.6	-0.9	-1.3	-1.0	0.7	-1.0	-0.3	-1.0	-0.7	-0.8	-1.1
Whole body water mass	0.6	3.6	19.4	2.9	1.0	0.6	1.1	-0.1	0.9	0.5	1.1	1.9	1.8	4.4
Leg predicted mass (right)	0.3	1.7	11.1	2.1	0.3	-0.6	0.5	0.4	0.2	0.2	0.2	1.1	0.9	3.3
Arm fat mass (left)	0.3	1.4	5.8	0.4	-0.8	-2.4	-0.5	1.0	-0.8	0.7	-0.8	-0.2	-0.4	2.4
Number of self-reported non-cancer illnesses	0.5	0.9	3.8	-0.9	-0.8	-1.9	-0.8	0.3	-0.8	-0.2	-0.3	-0.8	-0.8	1.4
Average weekly champagne plus white wine intake	0.2	0.3	2.7	0.4	0.1	0.2	0.0	0.0	0.0	1.6	0.6	0.3	0.4	0.6
Miserableness	0.3	0.5	1.2	0.7	0.4	-0.9	1.1	-0.8	0.3	0.4	0.3	0.7	0.5	1.1
Guilty feelings	3.0	4.5	6.7	2.4	2.2	-0.4	2.1	-2.3	1.9	1.9	2.6	2.5	2.3	2.0
Wears glasses or contact lenses	1.4	1.6	5.2	-0.3	-1.3	-1.4	-1.8	2.3	-1.3	1.1	-1.0	-0.9	-1.0	-0.3
Ever taken oral contraceptive pill	0.4	0.5	1.4	0.7	0.8	0.5	0.4	-0.5	0.8	-1.2	0.6	0.5	0.8	0.1
Hearing aid user	1.2	1.3	5.6	-0.2	-1.2	-2.4	-0.8	1.1	-1.4	-0.3	-1.4	-0.8	-0.9	0.4
Mother’s age at death	4.0	5.0	6.4	-2.2	-2.4	-2.4	-2.5	2.1	-2.4	-1.3	-2.4	-2.1	-2.2	-2.1
Financial situation satisfaction	2.1	2.5	3.5	1.7	1.7	0.4	1.5	-1.7	1.7	1.9	1.8	1.8	1.7	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	0.4	0.4	1.1	0.5	-0.2	0.6	0.2	0.1	0.5	0.3	-1.1
Commuting to job workplace: Public transport	0.8	1.0	2.1	0.8	1.1	1.2	0.9	-1.2	1.2	0.1	0.6	0.6	0.9	-1.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.6	-0.4	0.2	-0.1	0.5	-0.8	0.4	-0.7	0.4	0.1	0.1	-0.3
Medication: Blood pressure	0.2	0.4	1.4	0.6	0.5	0.4	0.6	-0.6	0.5	-1.2	0.2	0.7	0.6	0.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.8	1.2	1.5	0.5	1.0	-1.4	1.6	0.4	1.7	1.5	1.6	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.4	0.4	0.9	0.2	-0.3	0.7	1.0	0.5	0.3	0.3	1.2
High cholesterol (Self-reported)	0.1	0.2	0.8	0.9	0.0	0.7	0.2	0.4	0.2	0.4	-0.0	0.1	-0.1	0.8
Medication: Bendroflumethiazide	1.1	1.6	3.2	-1.4	-1.0	-1.5	-1.0	0.7	-1.0	-1.8	-1.7	-1.4	-1.2	-1.0
Medication: Paracetamol	1.9	3.0	8.3	2.5	1.4	0.7	1.3	-1.0	1.5	1.0	1.5	2.0	1.9	2.9
Medication: Lisinopril	0.4	0.6	1.3	-0.1	-1.0	-1.2	-0.7	0.4	-0.9	0.7	-1.0	-0.5	-0.8	0.5
Medication: Atorvastatin	0.3	0.4	1.1	-0.2	-0.6	-0.1	-0.8	1.0	-0.5	-0.1	-0.8	-0.8	-0.8	-0.3
Illnesses of father: High blood pressure	1.1	1.4	3.3	0.7	1.4	0.0	1.4	-1.8	1.1	-1.2	1.2	1.2	1.3	0.6
Alcohol drinker status: Never	0.3	0.4	0.9	0.6	0.4	-1.0	0.9	-0.6	0.1	-0.9	0.2	0.5	0.5	0.7
Ever smoked	0.9	1.5	11.2	-1.5	-0.1	-0.3	-0.4	0.1	-0.0	1.7	-0.1	-0.4	-0.2	-3.3
Basal metabolic rate	0.5	3.0	18.0	2.6	0.8	0.0	1.0	-0.0	0.7	0.5	0.9	1.7	1.6	4.2
Leg fat percentage (left)	0.4	1.3	5.6	-0.3	-1.0	-2.4	-0.6	1.3	-1.1	-0.2	-1.2	-0.7	-0.9	1.2
Arm fat-free mass (left)	0.8	4.2	21.2	3.0	1.2	1.1	1.2	-0.0	1.1	0.7	1.4	2.2	2.0	4.6
Number of operations (self-reported)	1.1	1.6	2.5	-1.2	-1.2	-1.0	-1.4	1.0	-1.1	1.6	-1.3	-1.3	-1.3	-1.6
Average weekly beer plus cider intake	0.5	0.7	1.4	0.7	1.0	1.2	0.9	-1.0	1.2	-0.9	0.6	0.6	0.8	0.1
Irritability	0.7	1.2	5.0	1.3	0.4	-1.1	0.6	-0.3	0.3	2.2	0.5	0.5	0.5	2.0
Risk taking	0.1	0.2	1.0	-0.2	-0.1	0.3	-0.3	0.5	-0.0	-0.4	-0.6	0.2	0.1	-1.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.3	0.1	0.1	0.2	0.3	0.1	-0.4	0.1	0.3	0.2	0.6
Fractured/broken bones in last 5 years	1.8	2.3	4.9	-0.8	-1.7	-2.2	-1.8	1.7	-1.8	-0.6	-1.8	-1.5	-1.4	0.1
Age started oral contraceptive pill	2.2	2.8	4.4	-2.1	-1.6	-1.9	-1.5	1.4	-1.6	0.0	-1.6	-2.0	-1.8	-1.8
Diastolic blood pressure, automated reading	2.4	7.4	19.1	2.6	2.3	1.9	2.9	-2.4	2.1	-3.0	2.1	2.8	2.7	4.4
Ever depressed for a whole week	1.7	2.1	6.4	0.9	1.3	0.8	1.3	-1.5	1.5	2.5	1.4	1.7	1.5	0.5
Unable to work because of sickness or disability	3.4	4.3	6.2	2.3	2.3	2.0	1.9	-1.8	2.4	-0.5	2.5	2.1	2.3	2.1
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.1	-0.5	-0.7	-0.4	0.8	-0.6	-0.3	-0.5	0.1	-0.1	-0.1
Myopia	0.8	1.1	8.1	-1.3	-0.1	1.0	-0.4	0.6	-0.0	-1.1	-0.3	-0.2	-0.2	-2.8
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.3	-1.3	-1.4	-1.4	-1.5	1.2	-1.4	2.5	-0.9	-1.3	-1.4	-2.3
Cholesterol lowering medication	0.9	1.3	5.3	1.3	1.0	2.3	0.9	-0.3	1.1	0.2	1.2	0.8	0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.3	0.5	0.5	-0.2	0.4	-0.6	0.4	1.1	0.8	-0.1	0.1	-0.3
Pain experienced in last month	0.3	0.4	2.9	-0.4	0.0	-0.3	0.1	-0.5	-0.1	-1.7	-0.6	-0.4	-0.5	-0.8
Supplements: Calcium	1.0	1.1	2.9	-0.6	-1.1	-1.7	-0.8	-0.1	-1.1	1.4	-1.1	-1.1	-1.1	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	1.8	0.2	-0.2	-1.4	0.2	-0.2	-0.2	-0.6	-0.4	-0.1	-0.0	-0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.3	2.1	0.8	0.1	-0.1	-0.3	0.0	0.1	0.8	0.4	0.3	0.3	1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.8	1.0	-0.4	-0.1	-0.7	1.0	-0.4	0.3	-0.1	-0.4	-0.3	1.3
Heart disease (siblings)	0.8	1.0	2.5	1.2	0.8	1.6	1.0	-1.3	0.8	-0.2	0.7	0.9	0.9	1.1
Alcohol drinker status: Previous	0.6	0.7	1.5	0.7	0.6	1.1	1.0	-1.2	0.7	0.7	1.0	0.7	0.5	0.4
Pack years of smoking	0.7	1.0	1.8	-0.1	1.1	1.2	1.1	-1.2	1.2	-0.1	0.8	1.3	1.2	-0.2
Impedance of whole body	0.7	3.4	11.2	-2.9	-1.1	-2.1	-1.2	-0.6	-1.2	1.1	-0.9	-1.8	-1.8	-3.3
Leg fat mass (left)	0.3	1.0	4.5	0.6	-0.5	-2.1	-0.1	1.0	-0.6	-0.2	-0.6	0.0	-0.2	2.1
Arm predicted mass (left)	0.8	4.1	20.8	2.9	1.2	0.9	1.2	-0.2	1.2	0.3	1.4	2.2	2.0	4.6